Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Longevity with Dr. Steven Gundry: Rational Wellness Podcast 133
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Dr. Steven Gundry discusses Longevity with Dr. Ben Weitz.

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Podcast Highlights

5:05  The subtitle in Dr. Gundry’s new book, The Longevity Paradox, is How do you die young at a ripe old age?  Most of us want to live a long time but we don’t want a future that includes coronary stents or bypass surgery, joint replacements, living in a nursing home, and not remembering your name.  We want to remain healthy and vibrant for as long as possible.  Dr. Gundry said that we need to make sure that our microbiome is healthy, since this has a major effect on our health.  And this approach resonates with the Functional Medicine approach which usually prioritizes the gut as the focus of our health.

8:35  Dr. Gundry recommends taking prebiotic fibers to help the microbiome.  He explained that while probiotics that are sold are generally not native to our gut and many are dead by the time we consume them and they make their way into our guts.  And even if they are alive, they only become temporary visitors to our microbiome.  Prebiotic fibers are actually the fertilizer to help our native bacteria in our microbiota to grow, so this may be more important than taking probiotics. Eating fermented foods is good because these contain probiotics and the fermentation process breaks down the lectins.

13:04  One of Dr. Gundry’s most controversial positions is his recommendation to avoid eating foods that contain lectins.  But there are many foods that are generally considered to be healthy and that are commonly eaten that contain lectins that Dr. Gundry recommends avoiding, like lentils and other legumes, whole grains, potatoes, tomatoes, and cucumbers, among others.  Dr. Gundry advocates that most people should avoid the major sources of lectins, since this will reduce inflammation in their bodies, including in their arteries.  He mentioned a paper that he presented at an American Heart Association Vascular Biology meeting, Remission/Cure of Autoimmune Diseases by a Lectin Limited Diet Supplemented with Probiotics, Prebiotics, and Polyphenols where he demonstrated that removing lectins in 102 patients resulted in vascular inflammation subsiding and 80 out of the 102 were able to be weaned off of immunosuppressive and/or biological medications without rebound.  Dr. Gundry also pointed out that one of the reasons so many of us are sensitive to lectins is that our microbiome, which enjoys eating lectins, has been damaged from broad spectrum antibiotic use in us and in the animals we eat and from pesticides and glycophosate.  Another reason is our lack of stomach acid from the common use of stomach acid reducing medications. Dr. Gundry does think that pressure cooking beans and lentils that inactivates the lectins are ok to eat and he mentioned the Acciarolis in Southern Italy, which are one of the longest lived societies, who have a diet consisting mostly of anchovies, rosemary, olive oil, wine and lentils, though they do not eat bread or pasta. Dr. Gundry mentioned that lentils are good source of polyamines, which are interesting longevity compounds, also found in mushrooms and Parmesan cheese.  Dr. Gundry recommends cooking with a pressure cooker like Instant Pot or a Ninja Foodi.

20:53  The concept is that plants produce lectins to prevent animals from eating them.  But don’t plants want animals to eat them and poop out their seeds in a different location to promote their propagation?  Dr. Gundry pointed out that the plants that produce fruits that they want to be eaten by animals cover their seeds with a hard shell, like an apple seed or a flax seed, neither of which we can break down in our digestive system. These plants do want animals to carry their babies off someplace else and poop them out away from the mother tree. But grasses don’t want their babies carried away. They’ve got an open space and they want their seeds to fall directly to the ground. They use a system, primarily lectins in the hulls, to dissuade predators from eating their babies.

24:05  Dr. Gundry believes that the positive aspects of the Mediterranean diet, (often touted as the healthiest way to eat), which are the emphasis on consuming red wine, olive oil, fish, fruits, and vegetables, are balanced by the negative aspects of this diet, which are the grains and beans.  So Dr. Gundry does not recommend the Mediterranean diet.  He points out that even though the Sardinians are one of the Blue Zones (the areas in the world where people live the longest), they have the highest incidence of autoimmune disease in Europe because they eat large amounts of grains in their diet.  Another Blue Zone region is the Okinawans and it is often said that they eat a lot of rice, but 85% of their diet is actually purple sweet potatoes and only 5% of their diet is white rice. White rice does not contain the lectins that are in brown rice. The other 5% of their diet is fermented soy in the forms of miso and natto.  So only a very small part of the Okinawan diet is grains and beans. And another Blue Zone is the Seventh Day Adventists in Loma Linda, where Dr. Gundry used to teach medical school.  The Adventists’ primary protein source is texturized vegetable protein, which is defatted soy meal that’s extruded under high heat and high pressure, which pressure cooks it, which removes the lectins.  Dr. Gundry points out that the common factor in all these Blue Zones is that they eat very little animal protein.

28:03  Dr. Gundry is a big fan of consuming a lot of olive oil and he also recommends cooking and frying with it as well.  Even though olive oil has a low smoke point, it is the least oxidizable oil of any oil studied and it beats coconut oil and avocado oil in terms of oxidation.  One of the main benefits of olive oil is the polyphenols and everyday olive oil has about 10 times the polyphenols of extra virgin coconut oil.  Unfiltered olive oil has even higher polyphenols.  If you cough a lot when you gargle the olive oil, this indicates a high polyphenol content. Dr. Gundry sells his own olive oil, which has the highest polyphenol content of any olive oil on the market: Gundry MD Olive Oil.  The American taste is for a very bland olive oil, which has a very low polyphenol content.

35:31  Dr. Gundry recommends nuts, but he does not recommend peanuts, cashews, or almonds, the most commonly eaten nuts in the US. As we all probably have heard, peanuts often have aflatoxins from the fungus that often grows on their skin. Dr. Gundry noted that a lot of his patients react to a lectin in the peel of almonds.  Blanching almonds will remove this. Cashews are from the ivy family and there is even a cashew picker’s disease where the hands of the cashew pickers get burned from the toxins and lectins in the peel of the cashews. He has found that he has had a number of patients that when they stopped eating cashews, their GI distress improved.

37:20  Too much animal protein can contribute to reduced longevity.  Dr. Gundry recommends limiting animal protein to 20-30 gms per day, though vegetable protein is unlimited.  Dr. Gundry said that his colleague at Loma Linda, Gary Fraser, has shown that incremental increases in animal protein incrementally decrease our health span and longevity.  Higher animal protein leads to an increase in the IGF-1, which is associated with more disease and lesser longevity. Dr. Gundry said that his older patients who are doing well are typically running lower levels of IGF-1, such as below 100.  Dr. Gundry argues that consuming higher amounts of protein does not improve muscle mass. He says that sarcopenia occurs because our gut wall has been damaged by eating lectins and when we repair our gut wall, albumin and total protein levels, if they were low, dramatically increase.

44:57  Dr. Gundry recommends intermittent fasting by skipping dinner one day per week and eating dinner early on a regular basis so that when you sleep, you activate the glymphatic system in the brain that squeezes toxins out of the brain, such as beta amyloid, and produces a brain wash.  You want to have at least a 3 hour period of time between eating dinner and going to sleep.  In fact, Dr. Gundry says that from January through June every year he fasts for 22 out of 24 hours of the day.  He said that almost all human societies until the present time went through prolonged periods of not much food, which usually correlated to the winter.  Humans are the fat ape and have the ability to go extended periods of time without eating.

                                                    



Dr. Steven Gundry is a cardiovascular surgeon who has changed his focus to a Functional Medicine/Integrative approach. He is the director of the International Heart and Lung Institute in Palm Springs and the founder and director of the Center for Restorative Medicine in Palm Springs and Santa Barbara.  He is the best selling author of Dr. Gundry’s Diet Evolution, The Plant Paradox, The Plant Paradox Cookbook, The Plant Paradox Quick and Easy, and his latest book, The Longevity Paradox.  Dr. Gundry can be reached through his website, DrGundry.com or by calling his office at (760) 323-5553.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111 or go to www.drweitz.com.



 

Podcast Transcript

Dr. Weitz:            This is Dr. Ben Weitz with the Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to the Rational Wellness Podcast on iTunes and YouTube and sign up for my free ebook on my website by going to drweitz.com. Let’s get started on your road to better health.  Hello Rational Wellness Podcast podcasters. Thank you for joining me again today. For those of you who enjoy listening through our Rational Wellness Podcast, please go to Apple Podcasts or wherever you listen to podcasts and give us a ratings and review. Also, you can find a video version on YouTube, and if you go to my website, drweitz.com, you can find complete transcripts and detailed show notes.

                                Our topic for today is longevity with Dr. Steven Gundry. Longevity refers to length of life. There’s a bacteria that’s over 250 million years old. There’s a type of clam that can live up to 500 years. The longest living mammals are whales, which can live for over 200 years. It’s generally thought that the limit to human lifespan is approximately 125 years with only 48 people in recorded history making it to age 115 and one recorded person making it to 122. The average lifespan is the longest in Hong Kong at 84.7 years, though I suspect that may be changing there with all the stress associated with what’s happening. The average lifespan in the US is approximately 78.8 years.

                                What may be more important than the lifespan is the health span, which is the number of years a person is healthy. Others make a distinction between chronological age, which is the number of years you’ve been alive and biological age, which is a measure of your physiological age and of your functional and health status. This may be measured with a test called the telomere length test. Anti-aging medicine can mean different things to different anti-aging clinicians. For some, anti-aging refers to improving the appearance of the skin with special creams and treatments and even surgery, while for other anti-aging specialists, the focus is on restoring the body’s hormones to the level of the 25-year-old by taking bioidentical hormones like estrogen, progesterone, testosterone and even growth hormone. For others, it means research and the reasons why aging occurs and finding interventions, whether they be changes in diet, lifestyle, exercise or the use of medications or nutritional supplements to positively impact these biological pathways and processes.

                                Dr. Steven Gundry does not really need an introduction, but he is a heart surgeon, professor and researcher who has changed his focus in his medical practice to nutritional and preventative medicine. He’s the director of the International Heart and Lung Institute in Palm Springs and the founder and director of the Center for Restorative Medicine in Palm Springs in Santa Barbara. He’s the bestselling author of Dr. Gundry’s Diet Evolution, The Plant Paradox, The Plant Paradox Cookbook, The Plant Paradox Quick and Easy, and his latest book, The Longevity Paradox. Dr. Gundry, thank you so much for joining me today.

Dr. Gundry:        Hey, thanks for having me on. Looking forward to this.

Dr. Weitz:           Absolutely. I just wanted to start by saying I’ve been following your work since listening to an interview that you did with Dr. Bland in 2011 on his Functional Medicine Update. It was before podcasts were popular and I was a subscriber for 25 years. At first, we used to get these little cassette tapes that we would pop in and then we would get these CDs. Anyway, I remember you came on and you talked about this patient, Big Ed, and he had all this coronary plaque and you looked at his scans and another cardiologist said there was no way that they could intervene. He also had this big shopping bag of supplements. You said, well, those are all going to be a big waste.

Dr. Gundry:        Yeah, I did say that.

Dr. Weitz:            You looked at some new scans and it turned out that he had reversed quite a bit of his atherosclerosis, so you started rethinking that they may have some benefit.

Dr. Gundry:        Yeah, that’s exactly right.

Dr. Weitz:           The subtitle of your newest book, The Longevity Paradox, is how do you die young at a ripe old age?  What do you mean by dying young at a ripe old age?

Dr. Gundry:        Well, The Longevity Paradox is that most of us want to live a long time but we just don’t want to get old. When we look at living a long time, it really doesn’t look very good. We’re looking at stents or heart surgery or joint replacement or living in a nursing home and not remembering your name or your family’s name. Just getting old doesn’t look very good. Particularly the last three years, our life expectancy in the United States has actually declined three years in a row, and people thought it was a fluke, but it’s now … We boomers sadly will probably be, unless something dramatically changes, will be the longest living Americans. Our kids and our grand kids, if things don’t change, will have shorter lives and more miserable lives.  The evidence is increasing that we had very little time in our lifespan where basically it was a fairly quick downhill boom. Now the reason longevity looks so bad is we spend a great deal of time in senescence, in getting worse and worse and worse. The whole point of the book is it does not have to be that way. It’s quite possible to die young at a very old age. I think that’s actually what most of us would like to do.

Dr. Weitz:           Absolutely. Essentially what you’re saying is instead of hitting 40 or 50 or 60 and a steady decline with all these chronic diseases, we want to have a high level of function and go screaming right into the end.

Dr. Gundry:        Yeah, that’s exactly right. One of the benefits of having one of my clinics in Palm Springs is that Palm Springs is often called God’s waiting room. I’ve had the pleasure of, for over 20 years, super old people and learning some of their tricks. Plus, for most of my career, I was a professor at Loma Linda University, which is the only blue zone in the United States. A lot of my career has been spent looking at the tricks of good older people. The book is taking what I learned in The Plant Paradox and learning a lot more on the microbiomes’ effect on aging and then giving folks an action plan. It’s actually exciting stuff.

Dr. Weitz:           Absolutely. Your focus on the microbiome is definitely part of the average Functional Medicine approach, which really prioritizes gut health as a major factor in many other chronic diseases. In terms of improving the microbiome, you recommend prebiotic fibers, which feed the gut bacteria. It’s very common to recommend probiotics, which are the gut bacteria themselves, but you don’t seem to recommend those. Why is that?

Dr. Gundry:        Well, I have nothing against probiotics. I make several probiotic formulas for my own company.  What I think most people don’t realize is that most probiotics are not native to our gut.  If they make it into our gut, and that’s a very iffy proposition, they basically stick around on vacation.  You have effects.  Yes, absolutely.  In fact, dead probiotics can have actually dramatic effect on the immune system.  Just to give you an example, there’s a dead yeast, the brand name is called EpiCor, that absolutely modulates the immune system and actually probably makes us make more red blood cells. Dead probiotics, what I tell people, for instance, in Palm Springs, if I sold grass seed to a patient in Palm Springs, which would be probiotics, and say go plant it. They’d come back a month later and said, you sold me bad grass seed because it didn’t grow. I said, well, what did you do? They said, well, I took it out on the desert and sprinkled around it. I said, well, did you water it? No, you didn’t tell me too. Well, did you fertilize it? No, you didn’t tell me to.

                                We have to give the microbiome prebiotics, the fiber that these bugs like to eat.  With the Human Microbiome Project, we’re beginning to realize that there are certain fibers that certain bugs thrive on, and if we give them what they want to eat, they will actually start taking care of us. We’re sadly or fortunately a condominium for bacteria and they outnumber us. There are a hundred of them. If you actually look at the genetic makeup, about 99% of all the genes in us are non-human gene. There are viral and bacterial genes. Most of what’s going to happen to us as I talk about in the book is not our heredity, is not our genes that we inherited, but the effect, particularly on environment and the microbiome, on our epigenome, on turning off and on genes.  That’s actually what’s exciting about this research that our fate is not fixed in our genome, but our fate is actually tied to our bacteria. We can feed them what they want.

Dr. Weitz:            What do you think about fermented foods like kimchi and sauerkraut and things like that?

Dr. Gundry:        I think it definitely has a place, but we have to remember that fermentation was one of the oldest forms of breaking down lectins in food. Fermentation is a really good way of bacteria and yeast eating lectins in plant materials. In fact, the Incas, who did knew how toxic it was, they had three preparations for kimchi. They soaked it for 48 hours and then changed the water. Then they allowed it to ferment and then they cooked it. It’s another package directions. Fermentation was a really good way to break down lectins. It gets back to the same thing. Probably most of the probiotics in fermented foods don’t even survive gastric digestion, but they can have compounds that educate our immune system. Ferment as many things as you can because it’ll break down lectins. How is that?

Dr. Weitz:            Okay, sounds good. Speaking of lectins, that’s one of the more controversial things in your books. One of the issues people have with it is there seem to be all these foods that people have eaten for many years that seem to be healthy like legumes and lentils and hummus and potatoes and tomatoes and cucumbers. A lot of people who seem to be really healthy eating these don’t seem to have any reactions. How can it be that these lectins in these foods are really harmful? The other question is, since we now can test for lectins and we can test for our sensitivities to eating these foods, wouldn’t it make more sense to test for those food sensitivities and lectin sensitivities and then decide whether or not it’s okay for our individual bodies to eat them?

Dr. Gundry:        Yeah, we do that often with patients who really … on why they continue to have an autoimmune disease despite a pretty good elimination diet or eliminating most common lectins, but unfortunately, insurance doesn’t pay for these tests. We found that eliminating most of the major lectins from most people’s diets have a profound effect on the inflammatory markers that we do measure. In fact, I just this year published another paper in the American Heart Association at the Vascular Biology Meeting where we showed that lectins are a major cause of vascular inflammation, and removing lectins from the diet of several hundred people showed that the vascular inflammation subsided, and reintroducing lectins caused the vascular inflammation to reappear.  To get back to your original point, we forget that the reason so many of us are now sensitive to lectins is that our microbiome, which is a major defense system against … plant lectins. The microbiome actually enjoys eating lectins. There is even a bacteria that enjoys eating gluten.  We’ve wiped out much of our microbiome from broad spectrum antibiotic use in us and also in the animals that we eat.

                           I think the other thing that we’ve lost sight of is that so many people take a stomach acid reducer without realizing that acid in our stomach are proteins and lectins are proteins. We’ve had that defense system gone in so many people. Lastly, almost all the foods that we eat have glyphosate, have Roundup, in them, and most people don’t realize that glyphosate was actually patented by Monsanto as an antibiotic.  It was not patented as an herbicide.  Glyphosate is really good at killing the microbiome.  Plus, work from MIT has shown that glyphosate by itself causes leaky gut.  We’ve set up a perfect storm where the vast amount of defense systems that we’ve enjoyed up until 50 years ago are pretty much wiped out. In the football analogy, not only is our defensive line injured, but all the linebackers are out.  A good running back like a lectin has a straight shot to the goal line time after time.  I think that’s what we’re seeing.

Dr. Weitz:           When it comes to legumes, from reading The Longevity Paradox, I came away with the idea that we shouldn’t eat legumes or lentils, but then I watch one of your YouTube videos where you said that properly cooked beans and lentils were okay.

Dr. Gundry:        In The Longevity Paradox, I make a very strong case for people eating pressure cooked lentils.  One of the longest lived societies who are the Acciarolis in Southern Italy, south of Naples, that I visited last year, these people have a fascinating diet.  They eat anchovies, rosemary, olive oil, wine and lentils. They actually, even though they’re Italians, do not eat bread or pasta.  They have absolutely no grains in their diet.  There are some compounds in lentils that are called polyamines, that are some of the most interesting longevity compounds that have been described.  Lentils are a great source of this.  Mushrooms are a great source of this.  Interestingly enough, true Parmesan cheese from Italy is a great source of polyamines.

                                I think everybody should have one of the modern pressure cookers like an Instant Pot or a Ninja Foodi.  They make things so easy.  In fact, I have a new cookbook coming out next month in November called The Plant Paradox Family Cookbook, which is dedicated to raising kids in this way.  Most of the recipes in the book are using it.

Dr. Weitz:            As an alternative to a pressure cooker, what if we soaked the lentils overnight and then cooked them in our rice cooker or however else we’re cooking?

Dr. Gundry:        I spent a lot of time in working with chefs in Italy and France and Spain and Portugal learning what their tricks were. Soaking of beans and lentils was always done. In the soaking, the water was changed every four to six hours and refreshed. Clearly, the evidence is very clear that soaking will remove a large amount of the lectins from the beans. What’s happened though is we’ve lost this connection with our parents and grandparents and great grandparents that these techniques, which were normally handed down from generation to generation, now that we don’t really have nuclear families anymore and great grandma is not helping in the kitchen, we’ve really lost these tricks. In our speed to have everything instantaneously, the idea that we would really bother to soak beans for 24, 48 hours is silly.  These cultures, it’s amazing, when I worked with chefs in Italy, not one of them would ever think of making a pasta sauce, a tomato sauce with tomatoes that aren’t peeled and de-seeded. I’ve been…. We’re missing these honored traditions of how we detoxified these plant compounds that are mischievous.

Dr. Weitz:            One of the concepts that people often talk about is they say this is the way that plants protect themselves against being eaten. Isn’t it the case that in order for plants to reproduce and grow in different places, they actually want animals and humans to eat them, so that we can poop out the seed somewhere else so that they can continue to flourish.  It seems to me that plants really want animals to eat them.  Perhaps the lectins are just there to discourage the bugs from eating them who really are not going to proliferate the seeds.

Dr. Gundry:        As I talk about in The Plant Paradox, there are two plants that make fruits in general want their predators to eat the seeds, but they, for the most part, protect those seeds with a hard shell that’s indigestible. For instance, we can’t digest an apple seed.  We can’t digest a flaxseed.  Just as an aside, I laugh when I see all these flaxseed crackers with whole flaxseeds or flaxseed cereal, and we cannot digest the outside of a flaxseed, which is why we have to grind them. They don’t use, because they can make a hard shell, they don’t use lectins to defend themselves, and they want the animal, their predator, to carry their babies off someplace else and poop them out away from the mother tree.

                                On the other hand, grasses don’t want their babies carried out. They’ve got an open space and they want their seeds to fall directly to the ground. They use a system, primarily lectins in the hulls to dissuade a predator from eating their babies. I think that’s a very important distinction that many people miss. The other distinction that people miss that I learned as a young man growing up in Omaha with the green apple two step, we often like to eat green apples long before there was a Granny Smith. These were immature apples. There was a very high lectin content in mature fruit to dissuade the predator from eating it before the baby seeds could … That system actually caused pretty impressive diarrhea and abdominal cramps. You usually learned your lesson very quickly.

                                One of the problems is so much of our fruit is now picked unripe in Chile or Argentina or Mexico and then flown long distances, and then we ripen that fruit with ethylene oxide and we never get the switch that turned off or decreased the lectin content as the fruit ripened naturally on the vine or the tree. I think there’s actually a big difference in the method of protecting seeds from being eaten.

Dr. Weitz:            Interesting. You state in The Longevity Paradox that it’s a myth that the Mediterranean diet promotes longevity. Haven’t there been a ton of studies showing that the Mediterranean diet is associated with lower rates of heart disease and longevity, etc. and actually the Mediterranean diet tends to emphasize lots of vegetables and olive oil, which I know you’re a big fan of, and even nuts and fish. Is it really the case that the Mediterranean diet does not promote longevity?

Dr. Gundry:        Interestingly enough, the work by Staffan Lindeberg in his book, Food and Western Disease, which I highly recommend to anyone, he shows data that grains and beans are a negative aspect of the Mediterranean diet that are compensated for by the positive aspects of the Mediterranean diet, which are the examples that you mentioned, red wine, olive oil, fish, fruits and vegetables. People, when they hear Mediterranean diet, think, oh, healthy grains and beans. His point and the research on that I think should be noted. For instance, the Sardinians, one of the blue zones, have the highest incidence of autoimmune disease in Europe, and it’s because they eat large amounts of grains in their diet.  Again, each diet is different. The case I make in The Longevity Paradox is that people who applaud blue zone diets as groups that eat large amounts of grains and beans somehow either having visited these places or don’t actually see what people eat. For instance, the Okinawans. The only actual description of the ancient Okinawan diet was made by the US government military occupying forces in 1949. The Okinawan diet was 85% purple sweet potato, blue sweet potato. About 5% of their diet was rice, but it was white rice, not brown rice because they got rid of the lectins in brown rice. Another about 5% of their diet was fermented soy, miso and natto, not tofu. There’s an example of great longevity that doesn’t eat grains and beans for the most part.

                                Even in Loma Linda, where I was a professor, the primary protein source, the Adventist diet was texturized vegetable protein, TVP, which we made into mystery meats of all sorts. This is defatted soy meal that’s extruded under high heat and high pressure. In other words, it’s pressure cooked soy meal. That was the staple, and nuts. It was the staple of the Adventist diet. Three of the blue zones use a liter of olive oil per week, which I highly recommend. Again, the Acciarolis, which is the newest discovery of the blue zones, they don’t eat grains and they eat lentils and they eat olive oil and anchovies.  The one thing that keeps all of these blue zones I think together is that interestingly, they have very little animal protein as a part of their diet. That’s the common factor of all these.

Dr. Weitz:            I want to get to the animal protein in a minute, but let’s hit on the olive oil thing. A lot of people in the health world are always trying to optimize what’s the best fat, what’s the best oil to cook with. You have so many vegans out there saying you shouldn’t cook with any oil. Other people are saying you should cook with only butter. Olive oil was the big oil and then everybody said no, it burns very easily at reasonable temperatures. It doesn’t hold up under high heat so we have to go to coconut oil or we have to go to avocado oil. Everybody is searching around trying to find the perfect oil. I know you feel that olive oil is not as problematic as some people think for cooking, right?

Dr. Gundry:        Correct. Olive oil has a low smoke point, but it actually is the least oxidizable oil of any oil studied. We’ve had actually two olive oil experts on my podcast, both of whom say the same.

Dr. Weitz:           What’s the difference between the smoke point and whether or not it oxidizes? Isn’t the oil getting damaged and…

Dr. Gundry:        No, it actually is the least oxidizable of any of the oils. It actually beats coconut oil and avocado oil in terms of oxidation. Nut oil and coconut oil don’t have a very high smoke point, so that’s for frying. Olive oil has been used for frying for 5,000 years in the Mediterranean, and so far so good. 

Dr. Weitz:           When you say it has a high smoke point-

Dr. Gundry:        Smoke does not mean oxidation. Not at all. It’s like steam coming off of water. There’s no damage to the water as you produce-

Dr. Weitz:           I think that’s where the controversy is.

Dr. Gundry:        Smoke point has nothing to do with oxidation.

Dr. Weitz:           Interesting.

Dr. Gundry:        I learned this from … I knew olive oil … I had no idea it was the best until I was shown the research by two of my guests. Son of a gun, you’re right. Look at that. The benefit of olive oil is that the polyphenol content of olive oil is extremely high, and you’re using oleic acid, which is the monounsaturated fat in olive oil and also in avocado oil. Isn’t that a particularly interesting beneficial oil or bad oil one way or another but it’s a carrier for polyphenol? For instance, plain old everyday olive oil has about 10 times the polyphenols of extra virgin coconut oil. If you agree with me and others that the more polyphenols in your diet, the better you’re going to be long term, then you want a high polyphenol olive oil.  When I do olive oil tastings in Italy, I go and study olive oil producers and learn there is one-cough olive oil, two-cough olive oil, and three-cough olive oil. The coughing that it induces and when we taste, we actually gargle the olive oil.

Dr. Weitz:           Really?

Dr. Gundry:        Really. We gargle olive oil. The more coughing it induces, the higher polyphenol content of the olive oil. You can use that trick to decide the polyphenol content of olive oil.

Dr. Weitz:           Do we want the extra virgin and do we want the unfiltered or which one is best?

Dr. Gundry:        You’ll have more polyphenols in the unfiltered. Extra virgin actually only refers to the acidic level in the olive oil, and it has nothing to do with the olives didn’t have sex or something like that. Sorry. I couldn’t resist. In processing olive oil, there is first press-

Dr. Weitz:           We’ll get censored by YouTube now.

Dr. Gundry:        That’s right. You should, if you can, get the nouveau olive, first batch of olives, which are usually picked green. As many people know, I now have my own olive oil, which is the highest polyphenol content of any olive oil studied, 30 times higher than any previous olive oil that comes from Morocco, of all places, in the desert where a brilliant family, fourth-generation olive oil farmers realized that great wine comes from grapevines that are stressed, that are under watered, that are planted close together and under harsh conditions. The more the plants are stressed, the more polyphenol content in the grapes, better wine.  This family tried this, and lo and behold, they planted their vines close … the trees close together. They under-watered them, desert harsh conditions, planted in rocks and voila, the polyphenol content is massive. They built a bottling plant in the middle of the olive grove so the olives are instantly pressed one time. I’m actually really excited about it.

Dr. Weitz:            Interesting, because there is a big controversy. You read these reports that some of the olive oil on its shelves doesn’t really contain olive oil. It’s olive oil spiked with other oils.

Dr. Gundry:        Yeah, there are actually several good American olive oils. There is a great olive oil at Costco that I recommend to people. It’s Kirkland brand. It’s a square bottle. It’s a plant in Tuscany. It carries a seal, a stamp for authenticity. If it says bottled in Italy, you can bring olive oil in tankers from Greece, Spain, all over the Mediterranean in tankers literally and bring it, un-dock it in Italy and then put it in a bottle and say it’s bottled in Italy. You do have to be careful.  The other thing that people should be aware of, the American taste is for a very, very bland oil. We’ve been raised on corn oil and canola oil. This cough when you have olive oil is not to the American palette.  Olives are blended in grocery stores to an American palette.  Most of the olives that are used have very little polyphenol content. The reason you’re using it, it’s usually not there.

Dr. Weitz:            Since we’re talking about fats, I see that you like nuts from your book, but you don’t like the nuts that are most commonly consumed, which are peanuts, almonds and cashews. I certainly understand some of the issues with peanuts with fungal problems, etc. What’s wrong with almonds?

Dr. Gundry:        Almonds, a lot of my patients with rheumatoid arthritis react to a lectin in the peel of almonds. There’s nothing wrong with peeled almonds. Anyone growing up in Spain knows their mother teaches them how to properly get the peel off of almonds because in Spain, anyone knows that the peel of almond is toxic. Again, you start learning traditions and go, how did that come about? I have about 70% of my practice is people with autoimmune diseases, and we have an interesting handful that clearly react to the peel in almonds. Blanching them is usually pretty safe for anybody.  The other big known … I dearly love cashews, but we have to remember that cashews are of the ivy family, and there’s even cashew pickers disease where the hands of cashew pickers get severely burned from the toxins and lectins in the peel of cashews. I don’t really particularly want to eat poison ivy.  I have a number of patients that cashews was one of their big issues in their GI distress until we got rid of them.

Dr. Weitz:            Now I want to hit on the protein. I’ve heard several discussions on your YouTube page about why we should have very low level of protein and how it’s associated with longevity. You mentioned 30 grams of protein. It hasn’t been the case that my experience shows that. One thing in particular is isn’t there a big difference depending upon who it is, how much protein they’re going to consume? Say, for example, me, somebody who’s worked out my whole life, very active, and my BMR is about 3,000 calories a day. If I’m only going to consume 30 grams of protein, first of all, where do I get the other calories from? Second of all, don’t I need more protein because I’m exercising more, I’m doing heavy resistance training, etc.?

Dr. Gundry:        Well, number one, I recommend that people, if they’re going to have animal sources of protein, they should limit their animal source of protein to 20 to 30 grams. Plant protein on the other hand is pretty unlimited in the amount that you can tolerate. The reason-

Dr. Weitz:            Shouldn’t it matter if you’re a 110-pound woman or you’re a 200-pound guy who’s very active?

Dr. Gundry:        Well, if you are actively building muscle then you can certainly use more protein, but my … is that protein primarily comes from plants. I’m a guy who grew up in Omaha, Nebraska, the beef capital of the world. Believe me, I enjoy a piece of grass-fed grass-finished steak every three months, but that’s it. The evidence certainly from the Loma Linda experience that’s been published by my colleague, Gary Fraser, shows that incremental increases in animal protein incrementally decrease our health span and lifespan. I wish that wasn’t true. I really do, but this is a huge follow up now for over 50 years. Each incremental increase in animal protein in an Adventist diet decreases their lifespan and their health span. Darn it.  Again, I’ve come to this, sadly, I really have, that there are components of animal protein, amino acid profile that increases our insulin-like growth factor. If you look at super old people, particularly in my practice, folks 95 and above, who are thriving, they run very low insulin-like growth factors. Most of them are in the 70s, 80s, some of them are in the fifth work at St. Louis University with the Calorie Restriction Society show those people when they were in physician-restricted vegan diet dramatically dropped their insulin-like growth factors. I see that in my patients as well.

                                I’ll give you an example. I just saw a couple in their late 60s who I’ve been working with for a number of years out of LA, and they used to be disciples, I mean phenomenal. Both he and his wife ran insulin like-growth factors around 80. Both of them ran hemoglobin A1Cs, 4.6, 4.7. She got a 4.4, phenomenal stuff. They went to Europe last summer for an extended period of time and fell off the wagon. It’s interesting. They have been struggling ever since that time. I saw them today for their six-month follow-up visit. We track these so that they can see it. Four years ago, they were both running insulin-like growth factors of around 80. Now she’s up to 160 on her insulin-like growth factor, IGF-1, and he’s up to 180, and their hemoglobin A1Cs have gone from 4.4, 4.6 to 5.4, both of them. 5.4, most people would be thrilled with 5.4. Most 68-year-olds would be thrilled to have an IGF of 160.  When you can look at what they did when they were spot on and they go, holy cow. They are aging right before their eyes and my eyes. Today was a real wake-up call for both of them. They said, okay, that’s it. We’re back. We’re going to hit this hard. That’s just-

Dr. Weitz:            That view, it definitely agrees with Valter Longo and a lot of the other anti-aging specialists these days. The focus all seems to be reduce growth. Anything that promotes growth, we want to reduce. We don’t want to encourage cancer cells. On the other hand, we know as we get older that our muscles tend to break down.  Sarcopenia is a problem.  There are people who can’t get out of nursing homes, and the only thing wrong with them is that their muscles are too weak. One of the problems with our brain health is that the neurons tend not to get replaced.  They tend not to regenerate.  We don’t create new connections between the neurons. A certain level of growth and regeneration is going to be crucial for anti-aging.  Isn’t that the case?

Dr. Gundry:        Yeah, I agree with that. The reason we have sarcopenia is because our gut wall is absolutely destroyed, and when you no longer have … It just pleases me so much that I can take patients and decrease protein consumption and watch their albumin and total protein, which were at dangerously low levels, actually dramatically increase. There are actually other really good studies of super old people that shows that increased protein consumption does not improve muscle mass. The reason for that is that most of us have been so damaged in the wall of our gut by leaky gut, by lectins that when we repair the gut wall, then everything else returns to normal. That is really the whole point of The Longevity Paradox.  Aging at its very core is caused by a breakdown in the wall of the gut. Hippocrates said this 2,500 years ago. All disease begins in the gut, and he was absolutely right. My addition to this is that all disease can end in the gut.

Dr. Weitz:            I totally agree with that. Intermittent fasting is something that’s often recommended for anti-aging purposes. We have complete fasting. We have intermittent fasting. We have the fasting mimicking diet. One of the things I noticed in your book is you recommend skipping dinner, which is interesting because right now, the rage in the Functional Medicine world is everybody skips breakfast, which I think is ironic because when I started counseling people on diet and health 30, 35 years ago, the word was everybody is fat because they skipped breakfast and they eat too much at dinner. The mantra was you have to eat breakfast, you have to eat within a certain period of time of waking up, and you have to have multiple small meals throughout the day. Otherwise, your blood sugar is going to be erratic.  It’s funny how it’s come full circle to now the way to be healthy is to skip breakfast, but you’re talking about skipping dinner. One of the things you talk about is I think you described it as flossing for the brain.

Dr. Gundry:        A brain wash.

Dr. Weitz:           A brain wash.

Dr. Gundry:        It’s interesting. We now in recent years have discovered the glymphatic system of the brain. The brain during particularly deep … about 20%. It literally goes through a wash cycle and squeezes out toxins such as beta amyloid. This needs actually high blood flow to accomplish this. I teach my patients that when I was growing up, we couldn’t go swimming for an hour after we ate lunch because we’d get cramps in our muscles and die. There was actually a bit of wisdom in that old wives’ tale in that when we are digesting, digestion takes a huge amount of energy and blood flow. After we eat, most of our blood flow is diverted to our gut for the purpose of digestion. Good studies show that the closer you finish dinner to the time you go to bed, the less efficient you are at washing out of having this brain wash cycle.

                           What I ask people to do is one day a week, skip dinner or finish four hours, maximum three hours before you go to bed, and allow that brain wash cycle to happen. Dale Bredesen, who is the author of The End of Alzheimer’s, has become a good friend. In fact, I just talked to him yesterday. He thinks, and I certainly agree with him, that we should have a 14 to 16-hour a day window of not eating. The easiest way to accomplish that of course is to skip breakfast and try to eat your dinner at say 6:00 at night. For half of the year, most of the people who follow me know that from January through June, I’m on that window so that 22 out of 24 hours, I’m fasting. This will be my 18th year of doing this, and so far, I’m not dead, so, so far so good.

                           Why do I do that? Because my study at Yale was in human evolution. We know that almost all societies up until the present time went through primarily a prolonged time of not much food, which usually correlated to the winter. As I tell anyone who listen, you really think our ancestors crawled out of our cave every morning and said, what’s for breakfast? There wasn’t any breakfast. We didn’t have a cupboard. We didn’t have a refrigerator. We had to find … If we didn’t find breakfast, break fast until lunch. That was break fast. We didn’t find it until dinner, that was break fast. The reason humans are like locust is that we have the ability to go extended periods of time without eating, unlike really any animal because we are the fat ape.

                           I agree. Joseph Mercola and I have talked about this. In our current environment, we have so many heavy metals and environmental toxins and pollutants and pesticides in our fat cells where we store them and we store them safely. If we undertake a fast, even a three-day fast, we have to realize that these toxins come out of our fat cells, and we have a horrible system of excreting these products and we actually reabsorb the heavy metals from our gut. The idea that in our modern society, a seven-day fast right off the bat is a good idea. I think that’s bad advice. There are ways to do this safely. Many of us make a supplement to help with this process. Mine is called Untox, but you can got it from other …  I think both his and my advice is this should not be undertaken and just, hey, I’m going to do it because it’s amazing how these things accumulate in us. We did it a hundred years ago. You’re right. Remember, all great … have fasting as a part of their process. Looking back, I think it was to give penance. It was actually a health technique. Every religion, regardless of whether there’s guilt involved with the religion, there are religions that don’t have guilt. They all have fasting.

Dr. Weitz:            Excellent, Dr. Gundry. I think we’ll have to wrap there. How can patients and practitioners get a hold of you and find out about your supplements and your books?

Dr. Gundry:        They can go to drgundry.com. My supplement site is gundrymd.com. I have the Dr. Gundry Podcast, wherever you get podcasts. I have two YouTube channels. You can find me on Instagram and Facebook. We do still see patients. I have a phenomenal physician’s assistant that is a blessing. People follow my Instagram account. Her Halloween costume, today is Halloween, she dressed up as Dr. Gundry. It’s hilarious.

Dr. Weitz:            That’s great. I should have dressed up as Dr. Gundry.

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Bioidentical Hormones with Dr. Cynthia Watson: Rational Wellness Podcast 132
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Dr. Cynthia Watson discusses Bioidentical Hormone use in Menopause with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on YouTube at https://www.youtube.com/user/weitzchiro/]

 

Podcast Highlights

4:02  During the perimenopausal period, which for women is typically in their late 30s and early 40s, their periods become irregular, either shorter or longer, or they may get heavier.  Progesterone and testosterone levels tend to fall and estrogen levels tend to go up.  This is because if women are not producing an egg every month, the FSH goes higher, which results in producing more estrogen.  Women tend to get symptoms of irregular moodiness, irritability, more PMS, depression and their sex drive goes down.

5:55  To support women during perimenopause, we need to support the adrenal glands. The adrenal glands produce hormones. Prior to menopause, 75% of the hormones are produced by the ovaries and 25% by the adrenals, but the adrenals take over after menopause. If women are really busy, working, taking care of kids, etc. this stress weakens the adrenal glands and the hormone production tends to decrease.  The adrenal glands will tend to take the progesterone to make more cortisol, so we may see progesterone levels fall.  Dr. Watson likes to check the luteal phase hormone levels around day 20-24 of the cycle to see how much progesterone, estrogen, and testosterone they are producing.  They may have high estrogen levels, which can cause breast tenderness, bloating, and irritability. Dr. Watson likes to use herbs and supplements to help lower estrogen and support progesterone. It may be helpful to give women some progesterone during that time in the cycle.

8:35  To help lower estrogen levels, Dr. Watson instructs her patients to avoid phytoestrogens in soy and other foods and environmental estrogens, like Bisphenol-A, and phthalates in personal care products. She will often recommend DIM, which is an extract from broccoli, which helps convert some of the estrone to a weaker form of estrone.  She may also recommend calcium d-glucarate and milk thistle to help with glucuronidation and helps to pull those estrogens out.

10:35  Dr. Watson prefers to do serum testing for hormones, though she recognizes the benefits of urine testing (such as DUTCH dried urine testing) for measuring hormone metabolites.  She mentioned that urine testing is not as good for progesterone, since progesterone is not seen in the urine but only it metabolites.

12:50  Dr. Watson likes to recommend Vitex (chasteberry) at a dosage of 200 mg twice per day to help with progesterone levels during perimenopause.

14:35  Some doctors feel that prescribing hormone replacement therapy for women after menopause is unsafe due to the results of the Women’s Health Initiative, published in 2002, (Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women’s Health Initiative Randomized Controlled Trial), which showed that taking estrogen and progesterone increases the risk of heart disease and strokes and blood clots and breast cancer.  Dr. Watson explained some of the problems with this study, including that the form of estrogen used, Premarin, is conjugated estrogen from the urine of pregnant horses, and the form of progesterone used is synthetic progestins and neither of these are comparable to bioidentical estrogen and progesterone.  Another issue was that most of these women did not start taking the hormones till they were 60 years of age, so they likely had already had developed heart disease and clotting from not having estrogen for 10 years.  This study had 10,000 women and in women treated with conjugated equine estrogens and progestins there were 32 cases of breast cancer and in the control group there were 24 cases of breast cancer, so there were only eight more cases in the treated group but it was recorded as a third more cases.  And in the arm of the study with women who had had a hysterectomy and took estrogen alone without progesterone and there was no increased risk of breast cancer.   With respect to the risk of heart disease and stroke, many of the women in the study were obese and smoked, which is what accounted for most of this risk.

20:46  Dr. Watson uses bioidentical estrogen and progesterone, which are much safer than using conjugated equine estrogens and synthetic progestins.  She prefers to use estradiol rather than Biest, which is a combination of estradiol and estriol, a weaker estrogen thought to be safer.  Dr. Watson said that since estradiol is more effective at reversing menopausal symptoms, if you give an estriol/estradiol combination like Biest, you may end up having to give higher dosages, which can have more side effects.  On the other hand, estriol is great to use topically for the vagina.  Dr. Watson emphasized that she individualizes her treatments and recommendations to each patient’s needs and how their body reacts. 

23:41  Dr. Watson usually prefers to use topical forms of estrogen and progesterone.  She tries to avoid using oral estrogen to avoid the first pass effect that can increase clotting factors and stress the liver.  If the patient will not apply the cream or some women do not absorb it very well, so sometimes she will use sublingual forms.  She will more commonly use oral progesterone, since she may have trouble getting good blood levels with topical progesterone. The oral progesterone doesn’t have the same risks as the estrogen and it helps better with sleep, so Dr. Watson will use the oral progesterone frequently.

25:54  Dr. Watson typically administers hormones statically, with the same dosage throughout the month, though some doctors will use a rhythmic pattern of dosage, such as with the Wiley Protocol. And she has recommended this for a few patients.  She does recommend that women with a uterus to take the progesterone regularly because it prevents the estrogen from leading to the uterine lining becoming thick.  Dr. Watson will often measure the uterine lining to make sure it is not becoming thicker.

28:05  Dr. Watson explained that it is an unanswered question at this time whether hormone replacement therapy protects the heart, but she said that it is important for this purpose if women start estrogen within the first year after menopause. 

31:08  If women have had a history of breast cancer but are having vaginal symptoms, Dr. Watson said that as long as she is cancer free and she is being followed by an oncologist, she may recommend the vaginal administration of estriol or DHEA or testosterone cream.  Testosterone can have antidepressant effects and other benefits, but it can also cause hair loss and acne and irritability and anger in some women.

34:10  Dr. Watson will sometimes include pregnenolone in her hormone replacement program if women tests low on it and have symptoms of MS or other neurological problems, since pregnenolone can be important for brain health, but she has not seen it raise estrogen levels.  She will typically prefer to start women on estrogen and progesterone alone before adding other hormones and make sure she can get the levels correct. Dr. Watson likes to use products from a good compounded pharmacy that tests every batch so that she can easily titrate up or down the dosages.  If you use a patch or pellets, you are stuck with whatever dosage is there.  Also, commercial brands of estrogen are often in an alcohol base and Dr. Watson prefers not to use an alcoholic base. And commercial products have various types of binders and fillers that some women can have reactions to.  Commercial progesterone is often in a peanut oil. By using a compounded pharmacy, you can use an olive oil or emu oil or canola oil or even a powdered base.  Dr. Watson usually does not start women on testosterone and DHEA at the same time as estrogen and progesterone till she feels that her patients are balanced.  She will typically have her patients come back in a month and retest their hormone levels and see where they are at and then add in DHEA and/or testosterone if their levels are low at that point. 

40:03  Dr. Watson believes that bioidentical hormones can be really beneficial for the brain.  This is partially through protecting the vascular system, which allows for maximal blood flow to the brain, which is maximized by starting the hormones close to the beginning of menopause.

42:15  Adrenal function is also very important to hormonal balance and Dr. Watson will frequently test serum cortisol and in some patients she will do the 4 part salivary cortisol testing or she will do the dried urine testing for adrenals with DUTCH Labs. To support the decreased adrenal function, Dr. Watson often recommends maca root, which is a great herb that can stimulate the production of both estrogen and testosterone.  She will also use licorice root to support adrenal production.  For women that have a spiking of their cortisol levels, phosphatidylserine, magnolia, and ashwagandha can be beneficial.

 

 



Dr. Cynthia Watson is a primary care Medical Doctor, board certified in family medicine, and she embraces a Functional Medicine/Integrative approach to care, incorporating nutritional and herbal medicine and bioidentical hormones into her approach to health and wellness.  She is still accepting patients and she can be reached through her website, WatsonWellness.org.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111 or go to www.drweitz.com.



 

Podcast Transcript

Dr. Weitz:            This is Dr. Ben Weitz, with the Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to the Rational Wellness Podcast on iTunes and YouTube, and sign up for my free E-book on my website by going to drweitz.com. Let’s get started on your road to better health.  Hello, Rational Wellness podcasters, thank you so much for joining me again today. For those of you who enjoying listening to our podcast, I would really appreciate it if you could go to Apple podcasts or your favorite podcast app and give us a review and a rating so more people can find out about it.  Also, if you want to see the video version go to my YouTube page. And if you go to my website, drweitz.com, you can find a complete transcript and detailed show notes.

                                Our topic for today is the use of bioidentical hormones during perimenopause and menopause with Dr. Cynthia Watson. Menopause is when a woman’s body is shutting off its reproductive capabilities. A woman is technically in menopause when she has not had her period for one year. During perimenopause, the period prior to menopause, and menopause, there is a gradual but dramatic decrease in estrogen and progesterone production by the ovaries resulting in a host of symptoms including hot flashes, night sweats, brain fog, mood swings, sleep problems, depression, weight gain, vaginal dryness, hair loss and fatigue among others. Long term effects of menopause include increased risk of osteoporosis and of cardiovascular disease.

                                Dr. Cynthia Watson is board certified in family medicine, and she embraces a functional medicine approach to care, incorporating nutritional and herbal medicine and bioidentical hormones into her approach to health and wellness. After two years at Ohio State University, she lived on a biodynamic farm in Norway, and developed an interest in the naturopathic medicine practiced on the farm. She also worked as a nurse’s aide in a homeopathic hospital in Germany. She got her BS in chemistry from Duquesne University, and she went to the USC School of Medicine. She has had her own private practice since 1991, and she incorporates herbs, nutrition, homeopathy, intravenous vitamins and bioidentical hormones into her integrative medical approach.  She wrote a number of books including Love Potions: A Guide to Aphrodisiacs and Sexual Pleasures, User’s Guide to Easing Menopause Symptoms Naturally, All About Lipoic Acid, and Better Sex in Midlife. Dr. Watson, thank you so much for joining me today.

Dr. Watson:        Thanks for inviting me, Ben.

Dr. Weitz:           What are hormones, and why should we care about them?

Dr. Watson:        What are hormones? Well, hormones, that’s a broad definition because you’re talking about steroids hormones and other hormones. Hormones basically are defined as something that’s secreted from an organ and it has an effect on another organ. But the sex hormones are the ones that we deal with in menopause and menstruation, and also for men too. They have hormones too.

Dr. Weitz:           Absolutely. What happens during the perimenopause, and how can we help women with their symptoms during this period?

Dr. Watson:        In perimenopause, there are a number of changes that can happen, and it varies from woman to woman. And it also varies according to age because some women will go into what we call perimenopause in their late 30s, early 40s, and some women will not even hit that period until the mid 40s. The timing for menopause is generally between 45 and 55. But prior to that, you’ll see a number of changes. The most common changes in terms of visual changes are problems with irregular periods, where the cycles will either get shorter or the cycles will get longer. And sometimes they’ll get heavier depending on what physiologic changes there are.  The most common things are that the progesterone levels fall, and the testosterone levels fall in perimenopause. And often, the estrogen levels go up. Because as women, we’re producing an egg every month, and as that gets weaker, the FSH gets higher, so the body is producing more estrogen. But the progesterone levels, and the testosterone levels tend to fall. And what that translates into is you’ll see women with either the cycles are getting shorter, where they’re having cycles every three weeks, it’s even every two weeks sometimes if they don’t produce an egg, and/or they’ll have 35, 40 day cycles.  And the other thing that goes along with that is a lot of irregular mood symptoms. I’ll see irritability, more PMS, more depression, and also lower sex drive too, because the testosterone levels tend to fall.

Dr. Weitz:            How can we support women during this phase?

Dr. Watson:        One of the most important things that I talk to my patients about is the adrenal gland. And I wanted to really talk a lot about that in this interview because as women, our adrenal glands produce hormones. They produce hormones just like the ovary does.  And as we go into menopause, the hormone production… prior to menopause, the ovary produces about 75% of the hormones. The adrenal gland about 25%, and that shifts as we go into menopause, whereas the ovaries produce less hormone and the adrenal gland takes over.  What I see a lot and women in our society, especially as we’re so busy, we’re working, we’re taking care of kids, we’re doing so many things, that the adrenal glands get weaker. And so we see the hormone production cut down. And especially where that happens is with progesterone, because progesterone is used by the adrenal gland to make cortisone. So what happens is something we call it the progesterone steal phenomenon where the ovary’s making estrogen, it’s making some progesterone, but the adrenal glands want that progesterone too. So as soon as that progesterone gets produced, it gets used up by the adrenal gland to make cortisone.

                                For me, checking a woman’s hormones, most gynecologists, we learn to check the FSH and the estradiol on day two or three to see how … the FSH is follicle-stimulating hormone, and that’s the hormone that is stimulated when we produce an egg. And as that goes higher, then we see less fertility and we see someone moving more into perimenopause.  But the other important thing to check during that time is what we call luteal phase hormones, where you want to check the estrogen and progesterone and the testosterone around day 20 to 24, depending on how long the cycle is, to see how much progesterone they’re making. And then depending on that … because I’ll see women with low progesterone, I’ll see women with super high estrogen levels, like 200, 400. I’ve even seen up to 700 and those women, they’re uncomfortable. They’re miserable. It’s like their breasts are tender, they’re bloated, they’re irritable. All of those symptoms go along with perimenopause.

Dr. Weitz:           What’s … Go ahead.

Dr. Watson:        What you have to do about that is you have to help to lower the estrogen levels with herbs and supplements, which work really well to do that. And then if the woman needs progesterone to give them progesterone during that time in the cycle.

Dr. Weitz:            What herbs and supplements can help lower the estrogen levels?

Dr. Watson:        This is an important thing because I see women in their 40s where the estrogen levels start to climb as a combination of just this hormonal cycle. And also because of the environment, because there’s a lot of the phytoestrogens and a lot of women are eating soy or they were being exposed to some of these chemicals, the xenoestrogens, which then block our ability to clear estrogen.

Dr. Weitz:           Like there’s Bisphenol-A, like pesticides.

Dr. Watson:        Right.

Dr. Weitz:           Like phthalate in personal care products.

Dr. Watson:        Exactly. So just being cautious and being aware. Those things actually clog up those cycles and make it difficult for us to metabolize the estrogens. And then there’s also genetic factors, which I’m looking at a lot of the genetic factors like certain CYP enzymes that they could have a polymorphism on. Or the COMT enzyme, if you have a polymorphism on those, then you also have reduced ability to clear the estrogen.  So what can you do? You can take a supplement called DIM, diindolylmethane, which is the broccoli, the extract from cruciferous vegetables, that actually helps convert some of the estrone into a weaker estrone. You can also take calcium d-glucarate and milk thistle. Calcium d-glucarate helps with the glucuronidation of the cycle and helps pull those estrogen levels out. And it really makes a difference for some women when they’re retaining high levels of estrogen.

Dr. Weitz:           Do you ever use indole-3-carbinol versus DIM?

Dr. Watson:        I tend to use more DIM.

Dr. Weitz:           And why is that?

Dr. Watson:        Well, just from some of the research that I saw that the DIM is the downward metabolite of the indole-3-carbinol, so the DIM is actually a little more effective.

Dr. Weitz:            Okay, great. You were talking about the hormone levels, the estrogen going up and the progesterone going down. What’s the best way to test or measure hormone levels? And we have serum, we have 24 hour urine, we have dried urine, we have saliva.

Dr. Watson:        Yeah, there’s a lot of different testing methods. I think I’m more partial to blood.  That’s what I’ve been doing for all these years, and I think it also depends on the practitioner and where their level of comfort is because I’m used to looking at blood.  I know how to interpret the blood, I’m comfortable with it. If that’s something that you’re comfortable with, I think blood levels are fine.  Your levels are helpful for the urine metabolites of the estrogen, so if you’ve got someone who you think is not metabolizing in the estrogen, you can get a lot of estrone metabolites, you can get the 2/16 hydroxyestrone and the 4-methoxy and 4-hydroxyestrone.  So you can see if someone’s got high estrogen where you need to help them in that cycle to clear the estrogen.  And so that’s really only with urine. So if I have someone where I really need that, I’ll do urine.

                                I think progesterone levels are not very good at urine because you’re not really measuring the actual level, you’re measuring a metabolite. I tend to use blood and I tend to check the blood depending on where the woman’s cycle is, I tend to check the blood between day 20 to 24. But if I have someone with a 21 day cycle, I’m going to do day 18, something like that.

Dr. Weitz:            We’ve started using the dried urine more and one of the things that’s beneficial for that is you were talking about trying to get a woman on day 18 to 21. And a lot of times, oh, shoot, that’s a weekend. I can’t go, I have to wait till next month. So this way they can do it at home and send it in.

Dr. Watson:        I’ll just adjust it based on whatever day they can do it. But yes, I sometimes do the urine as well.

Dr. Weitz:           Right. What else can we do as far as the progesterone? What do you think about using herbs to support progesterone production during the perimenopause?

Dr. Watson:        I love the vitex.

Dr. Weitz:           Right.

Dr. Watson:        Vitex is the best herb for women in perimenopausal symptoms

Dr. Weitz:           A.K.A. chasteberry.

Dr. Watson:        Chasteberry, yeah. Chasteberry is a great herb for that. I found a lot of my patients when you give them progesterone, they get side effects. Sometimes I’ll just go to the chase berry first, see how that works.

Dr. Weitz:           What dosage do you like for the chasteberry?

Dr. Watson:        I usually use about 200 milligrams twice a day.

Dr. Weitz:           Okay, good.

Dr. Watson:        But I don’t cycle it. I usually have them do it continuously.

Dr. Weitz:            Okay, good. What happens during menopause, and why is it that some women sail through menopause with fairly manageable symptoms and other the symptoms are severe and unlivable?

Dr. Watson:        I don’t also really know why some women have different symptoms because I’ve seen some women, you would think that some women who are a little more overweight, that they have more indulgence estrogen, that they wouldn’t have as many symptoms, but sometimes they do. I think some of it is genetic because I think some women if their mother had an easy menopause, that they may have an easy menopause.  And again, I go back to the stress issue. Some patients, if they’ve had a lot of stress and the adrenal glands aren’t able to carry them, they are going to have less estrogen. I’ve seen some women have very low estrogen levels, and then they’re fine, so I don’t know if we know why. But certainly, there are some women that have really disabling symptoms, and those are the women that I think are good candidates for the hormone replacement.

Dr. Weitz:            Now, isn’t it the case that the Women’s Health Initiative, which was published in 2002 showed that taking the estrogen and progesterone increases the risk of heart disease and stroke and blood clots and breast cancer?

Dr. Watson:        That study, as you know and as reported by many doctors and even some of the doctors that even were part of the study, that the results on that study were very confusing. I think, first of all, the product that was used on that study let me start with that, is Premarin and Provera. Provera is the synthetic progesterone. So physiologically, the effects of synthetic progesterone on the body are different. And Premarin, which is the pregnant mares’ urine is mostly estrone. So because of that, it’s a different kind of estrogen and it’s metabolized in the body differently. And to add to that it is also an oral estrogen, so we tend to try to use more topical estrogens in some women when women postmenopausal.

                                The other problem with the study is that most of those women in the study were actually not having menopausal symptoms. And the reason for that is because they were doing placebo controlled, so they were looking for women who didn’t have menopausal symptoms. Because if they did, they would know whether or not they were on a placebo or not, so that’s the first thing.  The other problem with the study was it was a prospective study. And a prospective study means that if there is a complication they need to stop the study. So it wasn’t just an observational study, it was a prospective study. And what happened-

Dr. Weitz:            Aren’t prospective studies the most accurate?

Dr. Watson:        Well, yes, but the way it was interpreted because there was a slightly higher statistical evidence of cancer, they had to stop the study. But the statistical evidence in that study was it was a very small group of women.

                                First of all on the estrogen, there was an arm of the study that was estrogen alone, they were just Premarin alone. These are women that had a hysterectomy. In that study, there was no increased risk of breast cancer. In the part of the study that had the estrogen with progesterone, those patients there were out of 10,000 women, there were 32 cases of breast cancer. In the control group there were 24 cases, so there were only eight cases more in the treated group. But because eight goes into 32 three times, it was recorded as a third more cases even though that was a very small statistical study.

                                Prior to that time many of the studies … First of all, there’s a wonderful book if patients want to read a little bit more about this that, I don’t know if you’re familiar with this book. It’s called Estrogen Matters, and it’s by Avrum Bluming. And he’s a wonderful gynecologist who … I mean oncologist who was in San Fernando Valley. He was one of my referrals. And he was one of the only doctors after breast cancer that would treat women with hormones and it became quite controversial. He was really in the firing line for a long time because of this. And then one day I was referring a patient when one day I found that he retired. And then a few months later, I saw this book saying Estrogen Matters, why we can give women estrogen even after breast cancer.  He’s the one that did a lot of the research and he produced a lot of studies. Up until that time there were very few studies that showed that there was an increased risk of cancer. And then in the studies in Europe, they started to use bioidenticals because they tend to use more bioidenticals. They use more pure estradiol, and they use a lot of natural progesterone. There’s a very large French study that did not show an increase in cancer.

So let me address the heart disease and the stroke.  Part of the problem too with that study is that many of the women in that study were obese, many of them smoked. And what they’re finding now is the risk of cancer and heart disease and stroke really has to do more with obesity, and that’s been one of the main things. There was a very large article that was written by NAMS, the National Menopause Society and the International Menopause Society showing that really, the risk of breast cancer and stroke in these women is that it’s really from the obesity that seems to be the problem.

 



 

Dr. Weitz:                            I’ve really been enjoying this discussion, but now, I’d like to pause to tell you about the sponsor for this episode of the Rational Wellness Podcast. This episode is sponsored by Pure Encapsulations, which is one of the few lines of professional nutritional supplements that I use in my office. Pure Encapsulations manufactures a complete line of hypoallergenic research-based dietary supplements. Pure products are meticulously formulated using pure scientifically-tested and validated ingredients. They are free from magnesium stearate, gluten, GMOs, hydrogenated fats, artificial colors, sweeteners and preservatives.

Among other things, one of the great things about Pure Encapsulations is not just the quality products but the fact that they often provide a range of different dosages and sizes, which makes it easy to find the right product for the right patient, especially since we do a lot of testing and we figure out exactly what the patients need. For example, with DHEA, they offer five, 10 and 25-milligram dosages in both 60 and 180 capsules per bottle size, which is extremely convenient.

                                                Now, back to our discussion.

 



Dr. Watson:        I use all bioidenticals and primarily estradiol.  I know some doctors use the Biest combination and I do use that in some of my patients, but I tend to use more of just pure estradiol.

Dr. Weitz:            And why is that?

Dr. Watson:        I found that some women don’t tolerate the estriol as much. And since the estradiol has the strongest effect on menopausal symptoms, what was happening is you’re giving estriol and estradiol because estriol is a weaker estrogen you were having to give higher doses of it. So there are some women especially some women, they just don’t do as well on it. Some women do, so I think it … Again, when I’m working with a patient, everything’s individualized. What I would give them would be on an individual basis, based on their body weight, their family history, whether or not it looks like they’ve had a problem clearing estrogen in the past.  Because I think that’s one of the other things that I try to really pay attention to. If I have someone who has a history of fibroids, ovarian cysts, PMS symptoms, they’ve had problems, if it looks like they’ve had or they have problems metabolizing the estrogen, I’m going to want to use lower levels.

Dr. Weitz:            I think a lot of the doctors who are using Biest or using estriol are using it to potentially lower the potential risk of breast cancer since estriol is a weaker estrogen.

Dr. Watson:        Right.  And then I have actually a couple of women who have had breast cancer and they’re on estriol.  Estriol is really great for the vagina. For vaginal dryness, estriol is a wonderful product for that, just for topical application.

Dr. Weitz:           Right, I know. I interviewed Dr. Gersh and she’s not really big on estriol because she explains that estriol is a dominant hormone secreted during pregnancy and it basically stimulates the estrogen beta receptors. And so you miss stimulating those estrogen alpha receptors that are so important. And overstimulating the beta receptor actually down regulates the immune system, which is maybe good for pregnancy, but not so good for fighting off infections or a cancer.

Dr. Watson:        Yeah, but when you’re using estriol in hormone replacement, you’re using such small doses compared to what the body is secreting in pregnancy. In pregnancy, you’ve got super physiologic, really super high levels.

Dr. Weitz:           And what form of the estrogen and progesterone? Do you like topical estrogen? Have you used pellets?

Dr. Watson:        I use whatever is going to work on the patient. I have generally tried to start with some of the topical forms because the topical forms, you don’t have to deal with that first pass effect. You’re using oral estrogen long term can increase clotting factors and you can have some concern with the liver…

Dr. Weitz:           By first pass, what you’re saying is when you take an estrogen orally, it goes into the-

Dr. Watson:        Highest levels go into the liver.

Dr. Weitz:           Right, exactly. Thank you.

Dr. Watson:        But I do use sublingual forms as well for some of my patients. Some women just do not absorb the creams or they’re not going to do it. They’re just not going to do it, so if it’s better in terms of using the … if you’re going to get better compliance, and they’re going to be happier using one of the other forms, I’ll use whatever is going to work.

Dr. Weitz:            Now, one of the issues with using the creams is that serum testing may not accurately reflect hormone levels if you’re using the creams. Is that right?

Dr. Watson:        They do sometimes. Well, I see both. I see some women where I’m just not getting good serum levels, that’s true.  And I know that salivary levels can be used for that.  My problem is salivary levels is that I’m just not sure how they know standardization, how they know what is an actual good dosage. But I see women on the creams all the time and on patches all the time. They get great blood levels, so I think that’s not as much of a problem. With the progesterone though, sometimes I have trouble getting good blood levels, and I have a lot of women that sometimes I have to switch them to oral progesterone.  The oral progesterone doesn’t have the same risks as the estrogen. It’s very well absorbed. It actually helps better with sleep, so a lot of my patients will do the oral progesterone instead.

Dr. Weitz:            Now, when a woman’s menstruating, her progesterone levels are much higher a couple of weeks during the period and estrogen levels tend to fluctuate and spike prior to ovulation. Do you use static dosing for hormones, or do you use rhythmic dosing?

Dr. Watson:        I tend to use more static dosing for hormones, although there are certain doctors that will do the rhythmic hormones and I’m learning a little bit more about that. And I have a couple of patients who have been doing that. There’s the Wiley Protocol, which was the first protocol for that. I think it just depends on the patient and what they’re going to be able to do.  If you have someone who’s not going to be able to pay attention to switching off and doing a different dose every single day, then you’re not going to get good compliance. I sometimes have trouble with women even remembering to take the progesterone. I’ll say like, you got to think that progesterone, it’s really important.

Dr. Weitz:            Right.

Dr. Watson:        … if you have a uterus.

Dr. Weitz:            Right.

Dr. Watson:        And there are some women that actually don’t have a uterus that like the progesterone anyway. They actually feel better on it.

Dr. Weitz:            So then the reason why the progesterone is so important for a women who has a uterus is because it stimulates the sloughing off of the increased endometrial tissue that happens from the estrogen, right?

Dr. Watson:        Well, it’s not so much sloughing off. It balances the possibility of the estrogen causing the lining to get thick.

Dr. Weitz:           Right.

Dr. Watson:        Because in women that are doing these static dosing, we don’t usually see them bleed, so it’s not like the lining is getting thick. If they’ve got an adequate amount of estrogen and progesterone, it’s usually … and also these are low levels. We’re not doing high levels like someone does when they’re menstruating. So you won’t necessarily see the lining get thick if you’ve got the dosage, right?

Dr. Weitz:           Right. Do you ever measure the uterine lining level?

Dr. Watson:        All the time. All the time, yeah.

Dr. Weitz:           Does hormone replacement therapy protect the heart?

Dr. Watson:        Well, that’s a controversial question right now. According to the research, if you start estrogen early on, if you start it early on in menopause in the first few years … That’s one of the things that we’re encouraging right now, is that the benefits that women get in menopause starting hormone replacement early. It’s better to start it early in terms of protecting the bones, protecting the heart, protecting the brain. What happened was when they took-

Dr. Weitz:           When you say starting early, you mean during perimenopause or shortly after menopause starts?

Dr. Watson:        Within the first year of menopause really.

Dr. Weitz:           Okay.

Dr. Watson:        I tailor my hormone replacement to women based on what their comfortable with. There are a lot of women that if they’re afraid they’re going to get breast cancer and they’re doing fine, then I’m not going to push hormone replacement on them. Years ago when I first started practicing and then there were a lot of women who were trying to decide whether to do hormone replacement because the research indicated that it had such good protection on the heart, I had patients come to me and say, my gynecologist wants me to take these hormones and I don’t want to do it.  Because the gynecologist were really like, “This is going to protect you and this is really important.” And then the study came out and everyone was like go off the hormones, these are bad, they’re dangerous, stop the hormones. Now we’re in a reset period, I think, where you have to really choose what is going to be best for your patient individually.

Dr. Weitz:           What do you think the consensus is right now in the standard gynecological community?

Dr. Watson:        Unfortunately, I think there are a lot of gynecologists out there that they’re against hormone replacement. Because I’ll have-

Dr. Weitz:           They tell the patients that they’re unsafe, right?

Dr. Watson:        Yeah, exactly, which I don’t believe to be true. Although, again, I think it depends on each individual person and based on their family history.

Dr. Weitz:            Yeah, from what I’ve seen…

Dr. Watson:        And also there are symptoms. If I have someone who comes in and they’re having no symptoms whatsoever, they’re sleeping fine, they’re doing fine, they’re not having any menopausal symptoms, I may just give them a vaginal cream because the vagina usually will need some estrogen support. But I’m not pushing hormones on someone just because.  Right now, the NAMS, the National Menopause Association, they recommend using hormone replacement for menopausal symptoms, for quality of life symptoms. And so if I have someone who’s really having bad symptoms, I will encourage them to use some hormonal placement.

Dr. Weitz:            What about women who have a history of breast cancer, but are having vaginal symptoms? I’ve heard some practitioners using topical testosterone and even topical DHEA for women who are really petrified about taking estrogen.

Dr. Watson:        There’s two classes of things here. There’s the woman who had breast cancer. Now, I actually have some of my patients who’ve had breast cancer on hormone replacement because their cancer was a slow growing cancer. It was easily excised, it was small, it was low risk. And their symptoms are so bad in terms of depression, mood swings, hot flashes, sleep problems, that I will put them on the dose of hormones.  But then if I have a woman who was menopausal, she’s had breast cancer and she’s not having any symptoms, or that she’s being followed by an oncologist who has specific like, don’t give her more most, you can use estrogen, just estradiol cream. You can use estriol cream, you can use DHEA. There’s a commercial grade suppository and then there’s an over the counter grade suppository with DHEA. Testosterone works great in these women and sometimes even helps with some of the menopausal symptoms. So all of those things are viable options for a woman that doesn’t want to do systemic hormones for just the vaginal dryness.

Dr. Weitz:            So, which is your go-to? Is your first thought to use a topical estrogen rather than the testosterone or the DHEA? Or do you think they all work equally effectively?

Dr. Watson:        For a woman that’s had breast cancer?

Dr. Weitz:            For a woman who’s had breast cancer, but who wants help with vaginal dryness and atrophy.

Dr. Watson:        Well, I’ll usually use the estradiol first just to see how they do. I check blood levels, so if someone has a low testosterone, I will. And testosterone is very well measured in the blood. And if someone’s testosterone is low, or the estrogen doesn’t work, or they’re having sexual dysfunction, where they’re having trouble with orgasm, testosterone works really well for that. It also works really well as an antidepressant. I’ve had some women even not with breast cancer, but some women. I had one woman, I gave her testosterone and she went off her antidepressant because she didn’t need it anymore.  So there’s a lot of good benefits to the testosterone, but there are side effects too. You can get hair loss, you can get acne, and you can get irritability, or some women even with the lowest dose of testosterone, they’ll get rage and irritability and sharp with their partner and we don’t need that. So some women just have bad effects with testosterone. But for the woman that testosterone works for, it’s amazing.

Dr. Weitz:            For your typical protocol when you have a woman … Getting away from the breast cancer thing, if you have a woman in the first year of menopause, and you’re going to put her on a program. Besides putting her on estrogen and progesterone, if testosterone levels are low, if DHEA levels are low, do you typically supplement those as well? And what about other hormones like pregnenolone?

Dr. Watson:        My experience with pregnenolone is though I love it and I think it can be important for brain health and function, especially if you have someone who’s got MS or even any neurologic problem, but I’ve never seen … theoretically, it’s supposed to have a cascade effect where you would take the pregnenolone and it goes into different pathways. I’ve not really seen it actually raise estrogen levels. So I will use it if the levels are low and if someone’s having those particular symptoms.   What I like to do is usually start them on estrogen and we discussed which kind to use. Like the patch, there are other issues like the controversy about compounded versus commercial brands because in the conventional medical wisdom like the OB-GYN’s group, ACOG, the American College of OB-GYN, they’re totally against compounding. They talk about compounding as being like it’s not measured, it’s not accurate, you have no way of quality control. And-

Dr. Weitz:            And there’s been a movement to try to shut down the compounding pharmacies, right?

Dr. Watson:        Right. And I try to use compounding pharmacies that I know that have reliability, that I know to do batch testing. They test their products, so I know that I’ve got someone who’s really paying attention. Have I seen some women get a batch and say this is not right or there’s something wrong with it, or some levels are really high? Yes, I have seen that before. Don’t forget, also even in the generic versus brand, there’s a certain percentage, like what, 20%, which doesn’t have … It has either low levels or higher levels.

Dr. Weitz:           Actually, it’s a whole other topic we can get into, but there’s a huge problem with generic drugs right-

Dr. Watson:        Drugs right now. Yeah, I’m seeing a lot of that with a lot of the drugs that I see. So I’ll use the patch. Again, it depends on the woman. It’s like if they don’t want to wear a patch because they’re swimmers or they take baths or exercise a lot, I’m not going to use the patch. But as someone who wants to be able to get the hormones covered by their insurance, the patch works great. And if they’re not going to take it, they’re not going to put a cream on every day. The patch works great, and it is bioidentical estrogen. It’s the pure estradiol. And then there are a couple of other-

Dr. Weitz:           What are the advantages of using compounded hormones?

Dr. Watson:        Well, I like them because you can titrate the dose more easily. And you can also decide, you can start with lower doses and titrate up if you have someone who you’re not sure what their dosage is going to be. It’s a little bit easier to do that.  And also, if you’ve got someone who you think is going to have trouble metabolizing the estrogen, I’ll have someone, I’ll give them estrogen and it’s like, whoa, it’s way too strong.  Even the lowest amount, you can have them stop for a couple of days.  Once you put the patch on, you have a little bit less regularity.  The other thing, some of the other commercial brands of estrogen that are available at the pharmacy, they’re in an alcohol base and I tend not to like those alcohol bases very much, but some women do fine with them.

Dr. Weitz:            And sometimes women can have reactions to the binders and fillers and things like that, that they’re made with. So by going to a compounding pharmacy, you can have some control over how they’re made.

Dr. Watson:        Some of my patients have the estrogen put in olive oil, which is very clean. They can just put it right on their skin. There’s a company that will make it an emu oil, and you can use hypoallergenic bases. So yeah, for especially someone who’s sensitive and going to be sensitive to chemicals, there’s a lot more options with compounded.  And also, I find that the regular progesterone, the commercial grade progesterone, is in peanut oil. And some women can’t do the peanut oil, so you can have the progesterone made in a compounding pharmacy in your olive oil base or canola oil base, or even a powder base.

Dr. Weitz:            And then how often do you add DHEA and testosterone as part of the mix?

Dr. Watson:        Well, I usually start a woman on the hormones and then recheck their … I like to use estrogen and progesterone alone to start because then if they have a side effect or there’s anything that changes in terms of their metabolism, then I know exactly what to do, and I’m not dealing with a lot of other variables. Because with the testosterone and DHEA, those hormones also can go into the metabolic pathways and if a woman has a very strong aromatase level in her body, she will convert that DHEA and the testosterone into estrogen. And I’ve seen that happen before.  I don’t want to add that in until I know what I’m dealing with, with how they’re doing with the estrogen. So I will start on estrogen and progesterone, and after about a month, I will check the levels and see where they are and then add in the DHEA and testosterone if their levels low.

Dr. Weitz:            What about the benefits of bioidentical hormones for the brain?

Dr. Watson:        There’s a lot of research that shows that the hormones really are beneficial for the brain. There’s certainly even in the women’s health study there, well, there’s some confusing things in that study. Because on the one hand, it did show that there’s less Alzheimer’s in women on hormones. But then there was at one point, a study that came out that showed there was increased dementia. And again, I bring up the issue is like in that study, those women were … Here’s the other benefit of starting the hormones a little bit earlier.  If you start a woman on hormones later, you don’t get the benefits to the vascular system and you can get more plaque formation, more atherosclerosis. One of the few things that no one talks very much about is that estrogen and progesterone have a protective effect on lipids. I see this all the time. I have a woman who’s got low … I’m one of them because I always had a cholesterol of 180 something. My cholesterol was a non issue, and as soon as I went into menopause, even on hormone replacement, my cholesterol was a little higher. My LDL tends to be a little bit higher.  So what happens in that study where they took all these women, they started a lot of these women in their 60s who could have had already vascular changes already. And then you add to that, the fact that you’re using an oral preparation, which increases clotting factors, so you’re going to increase the risk of stroke. If you look at all those statistics, you can’t make assumptions that if you start a woman in their early 50s on the bioidentical hormones, that it’s going to increase their risk of stroke because it’s like comparing apples and oranges. But it’s very clear that there’s better cognitive function in women on hormone replacement.

Dr. Weitz:           Oh, I just wanted to cycle back to one thing you talked about before. You were talking about the adrenals.

Dr. Watson:        Right.

Dr. Weitz:           Does the adrenal function, and how do you support adrenals?

Dr. Watson:        Well, first of all, you want to test. I’ll do a test, I’ll do … And part of my hormone panel is to check the cortisol levels. So I’ll look at cortisol levels.

Dr. Weitz:           So you’re are talking about serum cortisol?

Dr. Watson:        Serum cortisol levels, but in some of my patients, I will also do the salivary levels. Well, the spaces are 12 hours salivary test, where you do morning, noon, afternoon, evening.

Dr. Weitz:           Do you include the cortisol awakening response?

Dr. Watson:        Right, yeah. And so you’ll see some women who will still spike in the middle of the night, or you’ll see where they don’t really get a good cortisol … Cortisol should be higher in the morning and then go down as the afternoon goes up, but you’ll see some women that are flatline and then they go up at night. These are the women that are having trouble sleeping.  And then there’s also the dried spot urine. There’s a company that does the dried spot urine, where you’re doing the four samples throughout the day.

Dr. Weitz:           Right. The DUTCH testing?

Dr. Watson:        Yeah, the DUTCH testing.

Dr. Weitz:           Yeah, actually, one of the advantages of that is when you do the cortisol awakening response, and they have to spit into a tube as soon as they wake up, that’s always problematic.

Dr. Watson:        Right, yeah.

Dr. Weitz:            But The DUTCH testing, they just put a little cotton swab in their mouth, get it wet, and that’s all they have to do.

Dr. Watson:        Yeah. No, it’s a good test. It’s a good test. So for adrenals, I tend to use more herbs for the adrenal gland. There’s a lot of great formulas that are out there. One of the other herbs that really is good is maca root for women, for both perimenopause and into early menopause. And even some of my women who have had breast cancer, who don’t want to use hormone replacement, maca is a great herb because it doesn’t actually have plant estrogens in it. It basically helps stimulate the production of estrogen and testosterone. So maca is a great herb. Licorice root, just the ginsengs.

Dr. Weitz:            So now do you have different protocols if they’re seeing a spike in the cortisol in the evening, as opposed to when it’s just flatline the whole time?

Dr. Watson:        Oh, for sure. Because for the women that have the spikes, I’m using the phosphatidylserine products. There’s a couple of products that have phosphatidylserine. Magnolia works great. There are a number of commercial products that just help to lower that cortisol level, and so you give it to them in the evening, and that really helps. So, yes, I’ll use a lot of those.  Ashwagandha is another one. That’s another really good herb for women that are having that or even men, that are having that issue where they’re having trouble sleeping and we think the cortisol or the cortisol is spiking.

Dr. Weitz:            Right. And then the maca and the licorice root and some of those things to help stimulate the adrenals?

Dr. Watson:        Right. But again, it depends on the person. It’s like, if you’ve got someone who’s spiking cortisol you don’t want to do heavy duty adrenal stimulants. You want good adaptogens, and that’s where the ashwagandha and the maca root really help with that.

Dr. Weitz:            Okay, good. I think that those are the questions that I had. Is there anything else that you want to say before we wrap up our discussion here? And then-

Dr. Watson:        I know you asked me about the pellets and I didn’t really address that.

Dr. Weitz:            Yeah, okay.

Dr. Watson:        I know some women really benefit from the pellets and they like it because it gives them like … if they don’t have to really worry about putting something on like a cream or a patch or taking a vaginal-

Dr. Weitz:            Yeah, I know some women are concerned about the cream. It’s a pain, maybe it’s –

Dr. Watson:        Right.

Dr. Weitz:            … they don’t want to get it on their partner. There’s a bunch of different concerns that women have about the creams.

Dr. Watson:        So again, I think it’s a very individual decision. I think the issue that I have with the pellets is that I see really high levels, sometimes in women, and they get side effects from it, where they get breast tenderness because the levels are very high…

Dr. Weitz:            And you can adjust it once you-

Dr. Watson:        You can adjust it, yeah. So I tend to not use the pellets in my practice. But again, I had women who just love them. I had a couple of patients, it was great and they were very happy. So I think it’s again, we’re very fortunate in that we have options. We have a lot of choices for women. We get individualized therapy and I think of above everything, I think that’s the most important thing. There is no cookie cutter approach.  Years ago it was take Premarin and Provera, that was the thing. There was one dose and that was it. It is not a one size-fits-all. You really have to individualize it based on each individual patient, their genetics, where they are in life, how they metabolize the hormones. Everything’s got to be individualized.

Dr. Weitz:            What is the status, by the way, of compounding pharmacies?  I know that there was a movement to pressure the federal government into shutting down compounding pharmacies, and I know there’s a lot of controversy about it. Where are we in terms of that situation, the political situation?

Dr. Watson:        I’m afraid I’m not really up on the latest of that, except the compounding pharmacies they are still providing hormones for my patients, so…

Dr. Weitz:            Right, I know. I remember signing some petitions to try to keep them from closing them down.

Dr. Watson:        I don’t think they’re going to be able to close them down. I think there’s too many patients that are getting benefit out of it.

Dr. Weitz:            By the way, do you have a preferred dietary approach for menopausal women?

Dr. Watson:        Well, as we go into menopause, we definitely have metabolism changes. I see that, so you’re usually more into the paleo diet, into more like making sure you’re getting … It doesn’t have to be high protein, but you need to make sure you get adequate amounts of protein. I love a plant-based diet, and I think it’s really great, but it’s just not for everyone. And so some of my patients they are doing a plant-based diet, but it’s too high in carbohydrate, not enough protein.  And even if they are on a plant-based diet, as long as they’re getting good amounts of protein, they’re fine. But generally, the diet that I’ve been able to maintain my way into menopause, and how I do that is I eat a lot of vegetables and salads and lean protein and just keep the carbs and sugars to a minimum.

Dr. Weitz:            What about the women who are on a plant-based diet? How can they get an adequate amount of protein? How much protein is adequate, and how can they get that without consuming a lot of phytoestrogens?

Dr. Watson:        The recommended dose that I use is about 40 to 60 grams of protein a day depending upon what their needs are, in terms of how much they’re exercising. Especially though-

Dr. Weitz:            Your body weight and how much exercise, yeah.

Dr. Watson:        Yeah, because as you know, if women are exercising a lot, they need more protein. So using the protein supplements with pea protein or rice protein powders, just working with them on trying to avoid too much soy. So use other plant-based proteins.

Dr. Weitz:            What about that whole soy controversy? Because soy contains phytoestrogens and some of the data seems to show that soy is protective against breast cancer because when you…

Dr. Watson:        Right, that’s weaker estrogen.

Dr. Weitz:            You get the weaker estrogen, attach to the estrogen receptor sites and block the stronger estrogens. In a larger study I think, of menopausal women who consume the most amount of soy, these were women in China, who had a history of breast cancer, had the lowest risk of recurrence.

Dr. Watson:        I think there’s a premenopausal issue with soy and a postmenopausal issue with soy. Because certainly, in the premenopausal period when you have women with high hormone levels taking soy, then that’s a problem because it’s too much. And I’ve actually seen some women get breast problems and heavy bleeding and fibroids eating a high soy diet.  The other problem with soy is its effect on the thyroid. Soy has an anti-thyroid effect. So I’ll see some women if they’re drinking a lot of soy milk or eating a lot of soy based products, their thyroid goes off, their TSH will go up. But their thyroid is still functioning, but the TSH is up and then you get them off soy and their thyroid normalizes, so I’m not a big fan of soy because of that. Plus, it’s very difficult to digest and can cause a lot of GI bloating, gas issues.  But again, postmenopausal where you’ve got women who’ve got low estrogen levels, then those women may benefit from soy, as long as it’s in moderation. In places like China and Asia, they’re eating small amounts of soy. They’re not consuming large amounts of tofu and drinking soy milk. It’s a different kind of intake. They’re not taking large amounts of processed soy, though they may be eating tofu or something like that.

Dr. Weitz:            How else can these women get enough protein besides soy? You say plant-based protein powders with pea and rice?

Dr. Watson:        Yeah.

Dr. Weitz:           Those are the kind you like the most?

Dr. Watson:        Mm-hmm (affirmative), yeah.  If I see that they’re not … I have a couple of women that they’re working out quite a lot, and again, what I see in women that are doing a high plant-based diet is you have to watch their iron levels and you’ve got to watch their B12 levels to make sure they’re getting adequate amounts.  And yes, various different protein forms, and there are these different processed protein. So there’s the whole thing, the Impossible Burger and Beyond Meat and all that stuff, which it’s a very-

Dr. Weitz:           What’s your take on that?

Dr. Watson:        Well, it’s a very highly processed product. But again, it depends on if they’re not getting protein any other way then that may be something that they might need to do. But I just try to get them to do combinations of lentils and beans and rice and things, but just keep the portions small enough so they’re not getting a high carb load.  But it’s possible to do. We have people that are working out that are gaining muscle mass, and I’m sure you have them you have them too who are eating a plant-based diet. It’s definitely possible. You just have to be conscious about it. And what I tell people to watch for is watch for their sugar cravings because if you’re craving sugar, you’re not getting enough protein.

Dr. Weitz:           Or you’re taking in too many carbs, yeah.

Dr. Watson:        Right, yeah.

Dr. Weitz:           So your preferred diet is a paleo diet that’s basically lower in carbs, and it basically does not include grains and beans like the paleo diet does.

Dr. Watson:        Again, it depends on the person and how they have metabolize that, but for me, because I’m postmenopausal and I’m on hormone replacement and I’ve been able to maintain my weight all these years, that’s what’s worked for me. And that’s what has worked for me, so I’m still the same weight I was when I was in my 20s.

Dr. Weitz:           Great, awesome now.

Dr. Watson:        And I really don’t eat a lot of sugar. I think that’s the key. I keep that to a minimum in terms of sweets and candies and things. Not part of my diet.

Dr. Weitz:           That’s good. Okay, awesome. So how can listeners and viewers get ahold of you if they want to contact you or find out about your books?

Dr. Watson:        I have a website, but the books actually, unfortunately are out of print, [crosstalk 00:54:31] and I’ve been very busy in my clinic, so I haven’t really-

Dr. Weitz:           When is your next book coming out?

Dr. Watson:        That’s the question. Well, I am a full-time clinical practitioner, so not a lot of time to write books these days. Maybe when or if I slow down a little bit, I’ll have more time to do that. But it’s not part of my schedule right now. I’m pretty busy in the office. I’ve got a big practice, I’ve been practicing for a long time. I have people I’ve taken care of for a long time, so that’s the main focus for me.  My website is watsonwellness.org, so people can check that out. There’s a lot of information on the website about me. And yes, the books definitely are something that I would like to get back out again, but it just doesn’t seem to be part of the schedule.

Dr. Weitz:           Well, you can take one of those books in and just come up with a new version of it.

Dr. Watson:        Right, yes, that’s on my to do list.

Dr. Weitz:           And are you accepting new patients?

Dr. Watson:        Yes, I am. Yes.

Dr. Weitz:           Okay, awesome.

Dr. Watson:        Okay.

Dr. Weitz:           Thank you, Cynthia.

Dr. Watson:        All right. Thanks, Ben. You have a great day.

 

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Dr. Mark Houston on Preventing Heart Disease: Rational Wellness Podcast 131
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Dr. Mark Houston discusses Preventing Heart Disease with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on YouTube at https://www.youtube.com/user/weitzchiro/]

 

Podcast Highlights

4:11  There are a limited number of specific vascular responses to the many insults to our blood vessel walls that result in coronary artery disease. Dr. Houston said that there are 400 different risk factors for coronary heart disease and atherosclerosis. Whether it is E. coli or a heavy metal toxin or LDL cholesterol there are only three things the blood vessel can do to respond to these insults. There’s three of them called inflammation, oxidative stress, and vascular immune disfunction. When these responses occur in the artery wall, it creates biomediators that eventually lead to coronary heart disease or congestive heart failure, stroke, or any kind of cardiovascular illness.

5:47  There is much controversy over whether red meat contributes to heart disease, with a recent paper in the Annals of Internal Medicine, in which a group of doctors and researchers who call themselves the Nutritional Recommendations Consortium and who did an analysis of the literature and concluded that red meat and processed meat do not significantly contribute to heart disease and cancer, Unprocessed Red Meat and Processed Meat Consumption: Dietary Guideline Recommendations From the Nutritional Recommendations Consortium.  Dr. Houston said that red meat is not the problem, but what the red meat has in it that causes problems. If the cattle are being fed corn and grains, which contains pesticides and glyphosate, and they are given hormones and antibiotics, then this will not be healthy to eat. On the other hand, if you eat meat from organic, grass fed cattle, that will have a different effect in the body and is healthy to eat.  Numerous studies show that this type of red meat does not increase coronary heart disease of heart attack. 

9:06  Red meat contains saturated fat, which has been shown to be associated with heart disease.  Dr. Houston explained that there are different types of saturated fat based on the carbon length, whether they be 8, 10, 12, up to 20 carbons.  The long chain C-12 and up are the ones that may have an increased risk of coronary heart disease and heart attack. But Dr. Houston did caution that even this link between saturated fat and heart disease depends partially on where the fat is coming from what it’s associated with, what other kinds of fats are in your diet, and the percent in your diet.  The short chain fatty acids C-12 and below are not associated with coronary heart disease. Dr. Houston recommends to keep your saturated fat intake around 10% of your total calories and try to limit it to the short chain fatty acids.

11:41  Dr. Houston is not a big fan of coconut oil, since it is 92% saturated fat and it’s mostly longer chain fatty acids.  He feels that there is not much data that coconut oil has any health benefits.  This is in contrast to many Functional Medicine practitioners who feel that coconut oil is a healthier oil, partially because of the medium chain triglycerides that it contains.

13:10  One reason some people like using coconut oil is for cooking, since it’s high saturated fat content helps it to hold up to heat better than other oils without being oxidized. Dr. Houston is a big fan of olive oil and cooks with it at a lower heat, and he is careful not to bring it to a steaming point.  He cautioned not to overcook at too high a temperature.  He says that monounsaturated fats are healthy and he recommends pouring some olive oil on your food after you have cooked it.  He also recommends cooking with grape seed oil and avocado oil, which both stand up to higher heat. 

15:47  One of the advanced lipid tests on the market lists monounsaturated fats in the less healthy category and some physicians tell their patients not to eat them.  Dr. Houston said that monounsaturated fats, like olive and avocado, are healthy and they help to reduce coronary heart disease. They may not be as healthy as eating omega 3 fats, but much healthier when compared to saturated fats or refined carbohydrates.

17:00  Polyunsaturated fatty acids include both omega 6 fats, like most vegetable oils, which are not quite as healthy, and omega 3 fats, like fish oil, which are very healthy.  Polyunsaturated fats do break up in heat and can become unstable, because they have a lot of double bonds. Dr. Houston recommends that when you buy omega 3 fats, they should have tocopherol in the bottle to stabilize the oil in the bottle. And you should add some extra gamma-delta tocopherols to stabilize the omega 3 fats in your cells. Further, when you take EPA and DHA (omega 3s), you should also take a little GLA to balance out the fatty acid pathways.  Dr. Houston also likes consuming tocotrienols, but these should be taken 12 hours apart from taking tocopherols, and when you take tocopherol, it should be mostly gamma and delta tocopherol and not much alpha tocopherol.

20:32  The average primary care MD will usually order a basic lipid profile that includes total cholesterol, HDL, estimated LDL, and triglycerides, but this is an inadequate way to assess lipids.  Dr. Houston said that “Regular lipid testing is obsolete. Let’s make that very clear. Advanced lipid testing is state of the art.”  The estimated LDL on a standard lipid panel doesn’t tell you exactly how many LDL particles there are, which requires LDL particle number. The standard panel doesn’t tell you about LDL particle size, which is important.  It’s the small, dense LDL particles that are the bigger risk, that can more easily penetrate the endothelium and cause atherosclerosis and foam cells. Also, just getting an HDL is not as important as knowing HDL functionality, whether that HDL performs the reverse cholesterol transport that helps it reduce reduce coronary heart disease risk. So it is important to know HDL particle number and also size.

23:26  We used to think that only larger HDL particles were to be preferred, but the latest research indicates that the real small HDL are called prebeta and they dock to the macrophages and other tissues to literally remove LDL cholesterol and take it to the liver. Dr. Houston explained that all sizes of HDL are important, “You’ve got to have all of them to kind of transport from little to medium sized, to big through all these metabolic pathways, since they all can work through different metabolic pathways.”  There are actually 100 different proteins and lipids in HDL and if you knock most of them out, then it not only becomes dysfunctional, but it can become pro-atherogenic.  Patients who have very high HDL, say above 85, most of it will probably be dysfunctional. There is now a test from Cleveland Heart Lab that Dr. Houston is using in research to measure HDL functionality, Cholesterol Efflux Capacity, called HDL FX.  This test is not yet available for clinical usage.

26:44  When it comes to VLDL, you want smaller particles and larger VLDL, which is what people think of as triglycerides.  If you have a patient with high VLDL/triglycerides and low HDL and their LDL may be normal, but these patients have one of the highest risks for heart attack, because these patients usually have small, dense LDL.  For treating triglycerides, we can use omega-3 fatty acids, niacin, and fibrates (if you choose to use a drug).

28:18   There is a particularly artherogenic particle known as Lp(a) that is included in advanced lipid profiles.  The Biggest Loser trainer, Bob Harper had a massive heart attack, and his only significant risk factor was an elevated Lp(a).  Lp(a) is not modified very much by diet or lifestyle and is generally considered to be genetic.  There are some different techniques for measuring it, but 30 or less is considered normal and as you go over 30, the risk for heart attack goes up incrementally, as does atherosclerosis, coronary heart disease, clotting, retinal artery emboli, and aortic stenosis.  You can reduce it using certain nutraceuticals, including niacin and high doses of N-Acetyl Cysteine.  Dr. Houston said he also usually places patients with elevated Lp(a) on low-dose aspirin. Linus Pauling had a protocol using vitamin C, proline, and lysine in specific proportions, though there does not seem to be any published data on this.  It is designed to stop the attachment of Lp(a) to the artery wall.  In fact, most of the reports of nutrients to lower Lp(a) are anectdotal. Other nutrients that might help are vitamin C, L-carnitine, CoQ10, pantethine, and tocotrienols.   

31:37  Homocysteine is another factor in an advanced lipid profile and it is a bad actor.  It is more commonly elevated with MTHFR SNPs. It causes vascular damage, strokes, heart attacks, vascular dementia, kidney disease, and it’s elevated by a lot of things in your diet plus your genetics. The risk for homocysteine becomes dramatic at 12 and higher. He likes to get homocysteine to below 8 but 5 is optimal. To lower homocysteine we use methylated forms of B-6, B-12, B-9 (folate), and other nutrients like TMG.  We use various nutrients in the methylation pathway.  If needed, it can be helpful to order a methylation profile and see which enzymes can be helpful.

33:43  TMAO is a new marker for heart health that was developed by Dr. Stanley Hazen from the Cleveland Clinic.  TMA (trimethylamine) is a product that is found in  L-carnitine, choline, and phosphatidylcholine, commonly found in fish, red meat, chicken, eggs, and dairy are converted into TMA (trimethylamine) by certain gut bacteria, which is converted into TMAO (trimethylamine oxidase) by the liver.  TMAO has been associated with blocking reverse cholesterol transport along with other atherogenic effects.  Therefore, supplements of L-carnitine, choline, and phosphatidylcholine (lecithin) would theoretically also raise TMAO levels, but these nutrients have often been found to be beneficial and Dr. Houston mentioned that he uses L-carnitine in his protocol for patients with heart failure and choline is also a beneficial nutrient for the liver and for brain health, so it is hard to believe that we should really avoid these things.  Studies have consistently shown that eggs do not increase our risk of heart disease.  Further, fish is one of the healthiest foods that has consistently been associated with improved heart health, so this TMAO hypothesis seems to run contrary to much of the science.  Dr. Houston explained that when he has a patient with high TMAO levels, he will place them on a plant-based diet for a week or so and give them probiotics and prebiotics and this will usually drop the TMAO.  It may be that elevated TMAO levels are really just an indication of gut dysbiosis, since if you change their gut bacteria, the person no longer overproduces TMAO.

38:18   Which diet is best for preventing heart disease? Vegetarian (plant based), Mediterranean, Paleo, Ketogenic, or does it depend upon each person?  Dr. Houston said that if you go by science, the Mediterranean diet is best for heart disease, diabetes, and other health issues. This diet should consist of 10-12 servings per day of fresh, organic vegetables and fruits, cold water fish and high quality organic meat, and lots of monounsaturated fats like olive oil and nuts, and also lots of omega 3 fats both in the diet and as supplements.  You want to avoid refined carbs like bread and cereals and also pasta, white potatoes, and white rice.  Dr. Houston is not a big fan of the ketogenic diet because it raises your lipids and causes inflammation.  Dr. Houston said that for patients who are heterozygous or homozygous for the ApoE4 gene, they should be on a very low saturated fat diet, such as a vegetarian diet, but with lots of omega 3 fats and monounsaturated fats like olive oil.

41:22  Micronutrient deficiencies can play a role in heart disease. Dr. Houston said that he will often do micronutrient testing through SpectraCell, which measures intracellular levels in a functional way. Take magnesium, which is primarily inside the cells, so serum levels are not very accurate to tell if their magnesium level is low. And magnesium is involved in 400 different biochemical pathways.  When he has a patient with high blood pressure and he determines that they have 5 nutrients that they are low in and he repletes these micronutrients and their blood pressure goes to normal.

44:28  The most effective nutraceuticals/nutritional supplements for reducing plaque in the arteries are:  1. Omega 3 fish oil–4-5 gms per day of a high quality, balanced product with DHA, EPA, some GLA, and gamma-delta tocopherol, 2. A compound with nitrate, like beet root extract, that will raise nitric oxide levels, 3. Kaolic garlic, 4. Vitamin K2–MK-7 a minimum of 360 mcg per day, 5. Lactobacillus rhamnosus GG, 6. Luteolin, 7. Lycopene.

46:27  A Coronary Calcium Scan is a CT scan that looks for calcium in the arteries of the heart to screen for blockages.  There is a perception that this is the definitive way to determine if you have any blockages or not.  If you have a high coronary calcium score could mean one of two things: 1. You have calcium in a plaque in an artery, or 2. you have calcium in the arterial wall but not necessarily any blockages.  On the other hand, if you have a low score on your coronary calcium scan, it doesn’t mean that you don’t have heart disease because you could have a soft plaque in the arteries that is not calcified.  Dr. Houston talked about several patients who had 95% blockage in their LAD (the Left Anterior Descending artery, aka, the Widow Maker because a blockage in this artery) but a 0% coronary calcium scan.

48:33  Red yeast rice can be very effective and Dr. Houston often uses it, esp. with patients who are statin intolerant or who refuse to take a statin.   Dr. Houston cautioned that a lot of red yeast rice comes from China, so be careful to use a quality brand.  He usually recommends a relatively high dosage–4800 mg per day and he will often add berberine and other nutrients.  There is scientific data that shows that red yeast rice will prevent a heart attack.  Dr. Houston says that if he can get a patient on 4800 mg red yeast rice, berberine, a phytosterol and some niacin, he can reduce LDL particle number by 50%.  When Merck Pharmaceutical made lovastatin from red yeast rice, they took everything out except that one compound. But when you take red yeast rice, you get a composite of other ingredients that are beneficial for cholesterol and also for heart disease. Red yeast rice also reduce aneurysms and it is anti-inflammatory.  And Dr. Houston has found red yeast rice at even 4800 mg to be very well tolerated by his patients and has almost never seen a liver problem.  However, he will usually use CoQ10 with as he always does with statins to make sure that it doesn’t lower CoQ10 levels. He likes to keep the CoQ10 level over 3 mcg/deciliter. Statins tend to deplete not just CoQ10 but also vitamin E, omega-3 fatty acids, tocotrienols, carnitine, vitamin K2 MK-7 and vitamin K in general, vitamin A, Heme A, and selenium.

52:28  Plant Sterols. One testing company that does advanced lipids measures levels of plant sterols as a way to categorized if you are a hyper-absorber or a hyper-producer of cholesterol. Dr. Houston said that he tried using this type of test and he found that if someone is a hyper-absorber you block the absorption, the liver starts making more cholesterol.  He finds it better to just use a nutritional agent to block cholesterol production, like red yeast rice, and something to block cholesterol absorption, like plant sterols or berberine. Dr. Houston pointed out that berberine is a natural PCSK9 inhibitor, so you can either buy Repatha for $11,000 per year or you can buy some berberine for 30 cents a day.  Also, berberine is a natural form of metformin and it also turns off mTOR and turns on AMPK, so it is a natural anti-aging agent as well.

54:22  Tocotrienols if taken with red yeast rice or statins will enhance their effectiveness.  Tocotrienols block the production of the HMG-CoA enzyme for the messenger RNA.  They also break down the increased catabolism of the enzyme.   So it’s not a competitive inhibitor of HMG-CoA reductase.  It is best to take the red yeast rice or statin at night with the gamma-delta tocotrienols, which will result in a 10% decrease in LDL and LDL particle number.

55:20  Niacin has gotten a bad rap and many primary care doctors will tell you that niacin has no benefit, but that is because of two large clinical trials that had poor design and other methodological flaws. One study was The HPS2-THRIVE Collaborative Group. Effects of extended-release niacin with laropiprant in high-risk patients, which was published in the New England Journal of Medicine in 2014. Here is an article written by Dr. Houston and Dr. Pizzorno on the flaws in this study and why niacin is an effective agent:  “Niacin Doesn’t Work and Is Harmful!” Proclaim the Headlines. Yet Another Highly Publicized Questionable Study to Discredit Integrative Medicine. The other highly publicized negative paper on niacin was the AIM-High Trial, Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.  This trial actually did show that niacin significantly reduced LDL cholesterol and triglycerides and raised HDL, but they concluded that it had no clinical benefit. 

Dr. Houston emphasized that niacin is extremely effective at improving nearly every risk factor on an advanced lipid profile including the functionality of HDL, and there are many other studies showing niacin’s effectiveness, such as this study, Extended-release niacin or ezetimibe and carotid intima-media thickness, in which they found that “extended-release niacin causes a significant regression of carotid intima-media thickness when combined with a statin and that niacin is superior to ezetimibe.”  Dr. Houston explained that the only downside to niacin is if you get really high doses you might increase your blood sugar, you might increase your homocysteine, and you may flush.  But typically you can give a lower dose of an intermediate acting niacin and you will get really good effects that are beneficial for atherosclerosis. So, everything prior to these two inappropriate reports that had bad methodology, niacin worked great, so keep using it. Just make sure to get a good quality product.

57:46  Several years back, soluble fiber, such as in oatmeal, was touted to lower cholesterol. Dr. Houston recommends eating mixed fiber, both soluble and insoluble, and he said that fiber works through the microbiome.  Gut bacteria use the fiber to make chemicals that reduce diabetes, cholesterol, blood pressure and heart disease.

                             



Dr. Mark Houston is an internal Medical Doctor and a hypertension and cardiovascular specialist. He is the director of the Hypertension Institute in Nashville, Tennessee. Dr. Houston is triple board certified in hypertension as an American Society of Hypertension specialist and Fellow of the American Society of Hypertension, Internal Medicine, and Anti-aging Medicine.  Dr. Houston teaches at the Institute of Functional Medicine and the A4M programs. He is a prolific writer and has written What Your Doctor May Not Tell You About Hypertension, What Your Doctor May Not Tell You About Heart Disease, Nutritional and Integrative Strategies in Cardiovascular Medicine, Nutritional and Integrative Strategies in Cardiovascular Medicine, and his two latest books, Vascular Biology for the Clinician, and Precision and Personalized Integrative Cardiovascular Medicine. You can contact Dr. Houston through The Hypertension Institute web site HypertensionInstitute.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111 or go to www.drweitz.com.



 

Podcast Transcript

Dr. Weitz:                          This is Dr. Ben Weitz with The Rational Wellness Podcast, bringing you the cutting-edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to The Rational Wellness Podcast on iTunes and YouTube, and sign up for my free E-book on my website by going to drweitz.com. Let’s get started on your road to better health.  Hello Rational Wellness Podcasters. Thank you so much for joining me again today. For those of you who enjoy listening to The Rational Wellness Podcast please go to your Apple Podcast app or wherever you listen, whatever podcast app you use, and give us a rating and review. That way more people can find out about the Rational Wellness Podcast. Also, you can find a video version if you go to my YouTube page and if you go to my website, drweitz.com, you can find a full transcript and detailed show notes.

                                          So, our topic for today is how to prevent and reverse cardiovascular disease. In the 1950s and 60s, Ancel Keys and other researchers told us that eating too much fat, especially saturated fat such as found in red meat, butter, and cheese is the cause of heart disease. Saturated fat raises LDL levels which leads to cholesterol buildup in the arteries, end of the story. Thus, the lowfat mantra was born as a way to prevent heart disease, though, as we have learned after 30 or 40 years it didn’t really do all that much to prevent heart disease. We’ve learned that most of the cholesterol in the body is produced by the liver and it’s made from glucose. We have learned that consumption of refined carbohydrates and sugar is a greater contributor to raise our lipids and contribute to heart disease.

                                          But did you know that inflammation in the walls of our arteries increases the likelihood of cholesterol to be found lining our arteries, what we call atherosclerosis? That inflammation can be caused by many things including heavy metal toxicity, pesticides, mold toxins, chronic infections, food allergies, and consuming hydrogenated vegetable oils among other things. As we will learn today, cardiovascular disease is not just a metabolic disease but also an immunologically mediated condition. Dr. Mark Houston is our special guest today. He’s an internal medical doctor and a hypertension and cardiovascular specialist. He’s the director of the Hypertension Institute in Nashville, Tennessee. Dr. Houston is triple board certified in hypertension as a fellow of the American Board of Hypertension. He’s also board certified in internal medicine and anti-aging medicine. He has a masters degree in human nutrition and a Master’s of Science Degree. Dr. Houston teaches doctors around the world about cardiovascular medicine as part of the Institute of Functional Medicine and A4M programs.

                                          Dr. Houston is also a very prolific author, having written What Your Doctor May Not Tell You About Hypertension, What Your Doctor May Not Tell You About Heart Disease, Nutritional and Integrative Strategies in Cardiovascular Medicine, Nutritional and Integrative Strategies in Cardiovascular Medicine, and his two latest books, Vascular Biology for the Clinician, which has just recently come out and Precision and Personalized Integrative Cardiovascular Medicine, which will be out in November.  Thank you so much for joining me, Dr. Houston.

Dr. Houston:                      Thanks Ben, it’s good to be with you.

Dr. Weitz:                          Excellent, excellent. So, can you talk about some of the specific vascular responses that cause coronary heart disease?

Dr. Houston:                      Absolutely. The cardiovascular world’s literally been turned upside down as far as causes, insults, and how the arterial wall responds to all those insults. And as you rightly pointed out we’ve been mislead down the bad food path for 40 years and now we’re having to go back and reorganize our entire thinking process about that piece. But there’s about 400 risk factors for coronary heart disease and atherosclerosis.

Dr. Weitz:                          Wow.

Dr. Houston:                      Obviously we’ll talk about some of the top ones today, but the concept that I like to get across to people is that these insults that are coming in, the blood vessel can’t name them. It just sees what’s coming in and it may say, “Well, it’s an amino acid sequence or a fatty acid sequence.” So, E. coli, as far as the vessel’s concerned can look just like LDL cholesterol.  So the response is limited, it’s very limited. In fact, there’s only three things the blood vessel can do to respond to these insults. There’s three of them called inflammation, oxidative stress, and vascular immune disfunction. When those three go off in the blood vessel it can create all kinds of biomediators that eventually lead to coronary heart disease or congestive heart failure, stroke, or any kind of cardiovascular illness.

Dr. Weitz:                          Recently in the news there’s been quite a bit of back and forth about the role of red meat in heart disease and cancer with a recent paper in The Annals of Internal Medicine, where a bunch of researchers did a reanalysis of the existing research on red and processed meat and concluded that the evidence for harm from red meat was very limited and does not warrant recommending that citizens reduce their red meat and processed meat intake in order to reduce their risk of heart disease. They shot back with a rear affirmation, I think it’s World Cancer Council, that you do want to reduce your intake of red and processed meat  in order to reduce your risk of cancer.  We’ve got this back and forth on whether or not red meat is a factor in heart disease. Where do you come down on this controversy?

Dr. Houston:                      Well, it goes to show you can try whatever you want to in any journal wherever you go to read it. Pardon the noise. Here, let me get this. He’ll be gone in just a second, my apologies. So, let me try to give you the real truth about red meat.  The meat is not the problem. The red meat is not the problem. It’s what the red meat has in it coming from other sources related to the cow, okay?

Dr. Weitz:                          Okay.

Dr. Houston:                      If you have cattle that are eating corn, being fed bad food, given hormones, getting pesticides, and organicides, and gosh knows what else into their body, that’s going to go into the meat. Whereas if you get organic food and you don’t put any hormones or pesticides out in what they eat, the red meat is absolutely benign and doesn’t cause heart disease.  So, as you pointed out earlier, toxins, infections, pesticides, and hormones are probably the issue in all the bad stuff that’s happened with coronary heart disease and red meat. So, in my opinion, based on having looked at this very carefully also in the last two years, organic red meat is fine to eat. You can find numerous studies that say it does not increase coronary heart disease or heart attack.

Dr. Weitz:                          So, essentially what everybody’s forgetting about is the quality of the food when we are just looking at these macronutrient discussions. We’re not looking at the quality of the meat, we’re not looking at the quality of the carbohydrate, or the quality of the fat so what you’re saying is if we’re consuming a high quality red meat that’s organic, from grass fed cattle, that’s going to have a totally different biochemistry and a different effect in our body than eating feedlot cattle that’s shot up with antibiotics and hormones.

Dr. Houston:                      Exactly. In general what we like to do is stick with something that’s fresh and organic whether it’s a vegetable, or fruit, or meat, or some other kind of fat. Exactly.

Dr. Weitz:                          Right. So, since we’re on the topic of red meat part of the conversation about red meat has to do with the role of saturated fat. What’s your opinion about the role of saturated fat? Does saturated fat raise LDL cholesterol and does it play a role in the pathogenesis of atherosclerosis?

Dr. Houston:                      Well, I have written several articles in the period literature as well as in the book, On Integrative Strategies in CVDs, to talk about what is really the truth about saturated fats. So, this is what the literature is clearly showing now. A saturated fat is not just a saturated fats, there are different varieties within that. What determines what type of saturated fat is going to cause heart disease or not cause heart disease? And the primary issue relates what’s called carbon length. Carbon length 8, 10, 12, and on up to whatever, 20-something.  The long chain fatty acids, that is probably C-12 and up, are considered long chain. Those are the ones that may have an increased risk of coronary heart disease and heart attack, but even that’s somewhat questionable depending on where the fat’s coming from, what it’s associated with, what other kinds of fats are in your diet, and the percent in your diet.  But if you eat C-12 and below, the short chain fatty acids, there’s no evidence that any of those cause coronary heart disease or heart attack. So what I typically tell people to do is keep your total saturated fat intake around 10% or so of your total calories and try to limit it to the short chain fatty acids. It doesn’t mean you can’t have some long chain, it’s just don’t make those an abundant piece of your diet.

Dr. Weitz:                          So, which sources of saturated fat have the shorter chain?

Dr. Houston:                      What you want to do is you’ve got to read labels, that’s the problem. And labels, as you know, can be very, very deceiving. I think if you look at high quality meats of any sort, particularly if you’re talking about organic red meat or organic veal, organic chicken, organic turkey. Fish, obviously, don’t have hardly any saturated fats. They’re mostly monounsaturated and omega-3. Mostly omega-3s. Then you’ve got the end up just getting the good fats, doing that alone.

Dr. Weitz:                          So where does coconut oil fit into this? Because we know that coconut oil is a vegetable source of saturated fat and the arguments have been going back and forth on coconut oil. It’s been lauded by many in the functional medicine community as a wonder fat, and then we’ve got The American Heart Association still telling people not to consume coconut oil.

Dr. Houston:                      Yeah, that’s a loaded question. The coconut oil story is also very controversial. Coconut oil is 92% saturated fat, it doesn’t really have any other kind of good fats in it.

Dr. Weitz:                          Is it the shorter chain or the longer chain?

Dr. Houston:                      No, it’s the long chain. That’s the problem. It’s 92% long chain fatty acids. So, I wouldn’t recommend you consume a lot of coconut oil for that reason. A little bit just like what’s mentioned earlier is fine, but don’t get hung up on drinking a lot of coconut oil or consuming coconuts because they probably may not be healthy. There’s really not much data, honestly, that coconut oil has any really good health benefits. But on the other hand, a lot of it could be detrimental.

Dr. Weitz:                          Interesting, interesting, because I think a lot of people in the functional medicine world have put coconut oil in the healthy oil category.

Dr. Houston:                      I’d much rather you consume omega-3 fatty acids and olive oil, monounsaturated fats. They’re much healthier, with better data. When you get the coconut oil, you kind of don’t find much out there that’s going to help you for heart disease.

Dr. Weitz:                            Now, one of the reasons why people say they like coconut oil is because the saturated fat, because it’s saturated, it’s not going to react to oxygen or other things. Therefore, if you try to cook with a polyunsaturated oil, or you try to cook with an olive oil it goes rancid and gets damaged. Whereas, a coconut oil, because it’s a saturated fat, is not going to have that happen.

Dr. Houston:                      Another great question, what kind of oil should you cook with, and why or why not? The Europeans really laugh at us when we say we don’t cook with olive oil. They said, “No, no, no. We cook with olive oil all the time, just don’t boil it.” Because you will destroy it. We overcook everything. I cook with olive oil, but I don’t bring it to a steaming point.

Dr. Weitz:                          So, what is the temperature cutoff?

Dr. Houston:                      You get it warm, but if it starts…

Dr. Weitz:                          What is warm? Are we talking about 350?

Dr. Houston:                      I don’t know what the boiling point of olive oil is. The point is, you keep it on low simmer and when you see the olive oil starting to steam, you’ve gone too far. Now, you can cook with other oils obviously. Grape seed oil is good, you could cook with olive oil, and you can cook with coconut, or you can cook all these things; point is, just don’t overcook things. The other point is, if you want to cook with olive oil, go ahead and cook with it, pour off the olive oil if you think it’s bad, and then put some olive oil on your food when you put it on your plate. That’s fine.

Dr. Weitz:                            But you look at some of these charts and they’re very confusing. Extra-virgin olive oil has this temperature, another chart has the boiling point at a different temperature. Is it 325, is it 375? If you’re going to say baked vegetables, do we know what a safe temperature is if you’re going to use olive oil?

Dr. Houston:                      I don’t know that I have the temperature because you’d have to put a thermometer in your pan, and even then you’re not sure with all the other stuff in the pan whether it’s going to steam or not. Just don’t let it start steaming and you’re okay. Low temperature, sauteed.

Dr. Weitz:                          What about avocado oil for high heat cooking?

Dr. Houston:                      Avocado oil is fine, it’s a monounsaturated fat and it’ll tolerate the heat a lot better. It’s a good oil to use.

Dr. Weitz:                          By the way, since we’re on monounsaturated oils, we’re going to get to advanced lipid testing, but one of the companies that does advanced lipid testing now puts monounsaturated oils as less healthy. Do you know about this controversy?

Dr. Houston:                      Yeah, I do. I hear it all the time. And I hear a lot of physicians telling people not to use a lot of monounsaturated fats. That’s also not true. Monounsaturated fats, olive oil, nuts, olives are all healthy. There’s plenty of data to support the use for them in reducing coronary heart disease. Here’s the trick though, what’s your comparator?  So, if I want to compare monounsaturated fats to omega-3 fatty acids, they don’t look as good. But if I want to compare them to saturated fats, they look really good. If I want to compare them to refined carbohydrates, they really look good. So, it’s just your comparator. But, overall, monounsaturated fats are very healthy.

Dr. Weitz:                          Okay, since we’re on this topic what about since we just talked about MUFAs, what about PUFAs?

Dr. Houston:                      Okay, so, polyunsaturated fatty acids, those do break up in heat because they’re a lot of double bonds, and they can be more unstable. So how do you get around that problem?  Well, two things.  One, when you buy omega-3 fatty acids you want to be sure it has a tocopherol in with it.  Because, see, vitamin E, tocopherol, particularly gamma-delta tocopherol stabilizes the PUFAs, or the omega-3s in the bottle.  But you also need it to stabilize it in your cell membranes.  Whatever you consume when you’re using omega-3s, be sure that your product contains tocopherols, omega-3 DHA, EPA, but also another one, GLA. Because you’ve got to have those pathways lined up so you don’t distribute them inappropriately.

Dr. Weitz:                          Interesting. You know, I was using the gamma-tocopherol every time I took my omega-3s and was recommending it.  I recently switched over to tocotrienols after talking to Dr. Barry Tan and seeing the amazing research on tocotrienols.

Dr. Houston:                      Yeah, I know Barry very well and his data is incredible with all the forms of vitamin E. The tocotrienols don’t necessarily stabilize polyunsaturated fats, though. They have other tremendous health benefits. I take his gamma-delta tocotrienols, but also I take the gamma-delta tocopherols.

Dr. Weitz:                          Okay, so you take them both, but just not at the same time?

Dr. Houston:                      This is really important for your audience. If you take your tocotrienols and your tocopherols at the same time, and it’s more than 20% alpha-tocopherol, it’ll block the absorption of the tocotrienols. So, you’ve got to take them about 12 hours apart.

Dr. Weitz:                          Right, and when you take the tocopherols you want a higher gamma, right? You don’t want to take the alpha-tocopherol.

Dr. Houston:                      Yeah, you don’t want a lot of alpha. You want mostly gamma and, or, delta.

 



Dr. Weitz:                            I’ve really been enjoying this discussion, but I’d like to pause for a minute to tall you about our sponsor for this podcast. I’m proud that this episode of the Rational Wellness Podcast is sponsored by Integrative Therapeutics, which is one of the few lines of professional products that I use in my office. Integrative Therapeutics is a top tier manufacturing of clinician design, cutting-edge nutritional products with therapeutic dosages of scientifically proven ingredients to help our patients prevent chronic diseases and feel better naturally. Integrative Therapeutics is also the founding sponsor of TAP Integrative. This is a great resource for education for practitioners. I’m a subscriber to TAP Integrative. There’s videos. There’s lots of great information constantly being updated and improved upon by Dr. Lise Alschuler who runs it.

                                                One of the things I really enjoyed about TAP Integrative is that it includes a service that provides you with full copies of journal articles, and it’s included in the yearly annual fee. If you use a discount code Weitz, W-E-I-T-Z, you’ll be able to subscribe for only $99 for the year. Now back to our discussion.

 



                                               

Dr. Weitz:                          Okay, so it’s common for primary care doctors to order a basic lipid panel, which is total cholesterol, estimated LDL, HDL, and triglycerides. Sometimes in conversations with patients they’ll say, “Oh, yeah, yeah. I looked and all my lipids were fine.” Can you explain why this lipid profile is not an adequate way to assess for heart disease risk?

Dr. Houston:                      Absolutely. Regular lipid testing is obsolete. Let’s make that very clear. Advanced lipid testing is state of the art.

Dr. Weitz:                          That message has not… It either hasn’t gotten out, or the fact that the insurance doesn’t want to cover it…

Dr. Houston:                      Well, that’s even not an issue anymore. All the advanced lipid testing companies that we use, they’re covered by insurance and if they’re not they’re only like $60. So, it’s not that you can’t afford them. But here’s the really important part about advanced lipid testing.  Let’s take each lipid just individually because you have to do that. LDL cholesterol, different sizes, different atherogenesis, some are modified. So, let’s say you have a big, fat LDL and a real tiny LDL. Let’s use the garbage can analogy because people get this. Two garbage cans sitting in your back yard, if you look at them and say, “That’s my LDL.” And I say, “Well, which one’s bad?” And they go, “Well, I don’t know. They’re both bad, aren’t they?”  I say, “No, no. Take the lid off the garbage can. One side’s got tennis balls in it and the other side’s got golf balls.” And I say, “Well, which of those would you like to have.” And they go, “I don’t know.” I said, “You don’t want the golf balls because that’s the small, dense LDL. That’s when it penetrates the endothelium, goes into the sub endothelial layer and wreaks havoc, causing atherosclerosis and foam cells. The big ones on the other hand don’t necessarily get through as easily.”  So, if you have a lot of little ones the second issue is LDL particle number. The driving risk for coronary heart disease and heart attack is LDL particle number, number 1, and LDL size, number 2. That’s the LDL sort. You can’t get that on a regular profile. Second one is HDL. Well, HDL on a regular lipid profile is a static number. It tells you absolutely nothing. It doesn’t tell you about the size, it doesn’t tell you about how many particles there are, and it doesn’t tell you about its functionality.  So, the latest discovery in HDL cholesterol is the functionality is what determines whether or not it’s atherogenic or not. Second is HDL particle number, which is very important. But you don’t get either one of those on a regular lipid profile. You get a static HDL, which means nothing. It can be low, it can be high, and you see that number you can make no predictions whatsoever whether that HDL is good, bad, or ugly and what’s going to be protective to the patient.

Dr. Weitz:                          So you want larger HDL, right? That’s more protective?

Dr. Houston:                      Well, generally, that’s what we thought. We thought that larger was better than smaller. But it turns out that all of them are important because they all have a different process. The real small HDL they call prebeta, that’s the one that docks to the macrophages and other tissues to literally remove cholesterol, LDL cholesterol, from the tissue and then take it to the liver and dump it. You’ve got to have all of them to kind of transport from little to medium sized, to big through all these metabolic pathways.  So, actually, all the HDL’s are important, and it’s hard now based on data, because it’s getting complicated again, which size is better than the other.

Dr. Weitz:                          Oh, that’s really interesting. That’s kind of new news.

Dr. Houston:                      It is new, it’s the functionality.

Dr. Weitz:                          And by functionality, it’s producing reverse cholesterol transport?

Dr. Houston:                      Exactly right. RCT, reverse cholesterol transport, also called CEC, cholesterol efflux capacity, determines functionality. But the functionality of HDL is probably a hundred different things, so there’s like a hundred proteins and lipids in HDL. So, if all of them are working good it’s totally functional, but if you knock half of them out it’s kind of limping along. If you knock all of them out it’s not doing anything. In fact, HDL, look at this, if you knock everything out becomes not only dysfunctional, it becomes pro-atherogenic.

Dr. Weitz:                          Wow.

Dr. Houston:                      So now you can have an HDL that’s actually inflammatory or causing heart disease. That’s really bad. Now you’ve got nothing protecting you.

Dr. Weitz:                          And I think I’ve heard you say that if you have somebody that has a super high HDL, there’s an increased risk of that, right?

Dr. Houston:                      Yeah. If your HDL is over 85, most of it’s probably dysfunctional HDL; in a male, probably if it’s over 60. But this is another new, kind of, just came out like two months ago. There’s a U-shaped curve with HDL. People who have low HDL may be okay, people that are right in the middle, and then it goes up again it gets worse. So at either end you’re probably looking at an HDL that may not be working. So, it’s kind of got to be at a certain number. I think in the study it was like 32 to 35 was kind of the number that was at the bottom of the curve.

Dr. Weitz:                          Do you measure HDL efflux, cholesterol efflux capacity?

Dr. Houston:                      There’s a new test from Cleveland Heart Lab that does that. It’s not available clinically yet, but we’ve been using it now for about six months in a couple of research trials. The name of it is HDL FX, which stands for functionality. Cleveland Heart Lab has it, they’re in phase B trials right now. It probably will be out sometime in 2020 for the commercial use. That’s all we’ve got for RCT right now.

Dr. Weitz:                          You know, I’ve talked to a Dr. Sri Ganeshan, who has the MitoSwab test and I think that he’s just come out with a cholesterol efflux test.

Dr. Houston:                      I hadn’t heard of that one. I know the one with Cleveland is validated with clinical trials, and so as far as I know that’s the best one on the market right now.

Dr. Weitz:                          Okay. So you mentioned LDL and HDL particles. Normally we think larger is better, now we find out with HDL that’s not necessarily the case. But with VLDL, which most people don’t talk about, actually, larger is worse. Right?

Dr. Houston:                      That’s right. VLDL is basically what people think of as triglycerides, but VLDL comes in all sizes, too. And the big, fat VLDL’s are very atherogenic but also they cause thrombosis.

Dr. Weitz:                          Wow. So, I’m not sure everybody puts a lot of importance on VLDL, but you’re saying that we should?

Dr. Houston:                      Yeah. When you see somebody that has high triglycerides or high VLDL, and it’s the big fat one, can accommodate with usually a low HDL. That group of people are usually metabolic syndrome, diabetes, obesity. Those people are the ones that had the discordance between LDL and the LDL particle number.  So, here’s what happens. You go to the doctor’s office, he orders a routine lipid profile. All your triglycerides are high, your HDL is low, but your LDL’s okay. Well, it’s not okay because the LDL that that patient has is the small and dense, but increase LDL particle patient, that patient has one of the highest risks for heart attack of anything. And they’re ignoring that.   But, yeah, all of these need to be treated.  All the triglycerides. We use all kinds of things for that, omega-3 fatty acids, niacin, if you’re going to go to a drug–fibrates.

Dr. Weitz:                          Can you talk about the importance of Lp(a) for heart attack risk? There was a recent information about The Biggest Loser Trainer, Bob Harper, who had a massive heart attack and apparently elevated Lp(a) was his only significant risk factor.

Dr. Houston:                      Yeah, Lp(a) is genetic. There’s very little you can do to change it. Exercise, weight reduction, eating better doesn’t usually modify LDL… Excuse me, Lp(a) very much. So, when you’ve got this genetic type you have to get a lab that knows how to measure it, number one, because many a labs don’t give a good quality measurement of Lp(a) so you get deceived into whether you’ve got a problem or not.

Dr. Weitz:                          Really? So there’s different ways to measure it?

Dr. Houston:                      Yeah. Some measure mass, some measure different technology. So, you’ve got to find out whether your lab is consistent and has the best technique. That’s number one. Now, assuming it’s elevated, it’s a matter of degree. 30 or less is normal. Incrementally over 30 the risk for heart attack goes up. If you’re like 40, not too bad. But if it’s 150, yeah, you’re in trouble. And what Lp(a) does is it causes atherosclerosis, coronary heart disease, MI, clotting, retinal artery emboli, and aortic stenosis. So, it’s a bad actor. And there’s not many things we have to lower it. Niacin and NAC are the two that seem to be the best

Dr. Weitz:                          And how much do you think it’s reasonable to lower it?

Dr. Houston:                      Well, you try to get it down as close to 30 as possible. It’s hard to do that, but you’re going to have to use high doses of niacin, high doses of NAC, usually put them on low-dose asprin to kind of help block some of the clotting effects. There’s a whole list of stuff, Ben, that has been reported to lower Lp(a). Most of it’s anecdotal. I mean, we’ve got vitamin C, carnitine, CoQ10.

Dr. Weitz:                          Yeah, a lot of people talk about this vitamin C thing. I guess there was one study on that.

Dr. Houston:                      A lot is Pauling’s Protocol.

Dr. Weitz:                          Right.

Dr. Houston:                      It makes sense, the protocol basically stops the attachment, we think. Lp(a) to the vessel wall. But I can’t find any data that Linus Pauling ever published that documents that in humans. They probably got some rat studies, whatever. I’ve used it on people just because sometimes you don’t have anything else you can do and it’s pretty benign. Vitamin C, proline, and lysine in the right proportions.

Dr. Weitz:                          Right. I had a patient who came in today and in about a year we got it down from about 96 to 60 with niacin, a fairly modest dosage. One time I had a patient, couldn’t get her Lp(a) to budge and I sent you an email, this is several years ago, and you said, “Pantethine and tocotrienols.” And, bam, perfect. It was unbelievable.

Dr. Houston:                      Yeah, well, like I said there’s about 15 things on my list for Lp(a). When I get backed into the wall I start whatever I can and see if it works.

Dr. Weitz:                          Well, that worked unbelievable.

Dr. Houston:                      That’s great, good news.

Dr. Weitz:                          How important is homocysteine? That’s often part of an advanced lipid profile.

Dr. Houston:                      Yeah, the protocol that we use has homocysteine on the advanced lipid tests along with C-reactive protein. But homocysteine is a bad actor, too. Most of the studies you read, it’s kind of poo-poo homocysteine. It’s obviously not a big problem, don’t worry about it.

Dr. Weitz:                          Homocysteine is a protein found in the blood that’s independent of cholesterol as a cardiovascular risk factor.

Dr. Houston:                      Yes, and this is very common with MTHFR, heterozygote, homozygote, causes vascular damage, strokes, heart attacks, vascular dementia, kidney disease, and it’s elevated by a lot of things in your diet plus your genetics. But the risk for homocysteine becomes dramatic at 12 and higher. That’s when the curve shoots straight up. I like to get it below 8 in everybody I can, but if I can get it to 5 that’s where the curve becomes fairly flat.

Dr. Weitz:                          5? Wow.

Dr. Houston:                      If you can get there. The risk at 8 is pretty low, but it’s starting to go up. 12, through the roof. So, if you see it up over 12 you’ve got to work hard to get it down.

Dr. Weitz:                          So to lower homocysteine we’re using methylated forms of B-6, B-12, B-9. Are there any other nutrients that can be beneficial if that sort of B vitamin strategy doesn’t get you where you want to go?

Dr. Houston:                      The cocktail, as you know, is methylated folate, B-6, and all the others. There’s about 10 things in that methylation pathway and there’s, as you know, there’s all kinds of snips you have to measure. Not just MTHFR that can be the problem, and if you find out which snip’s missing you kind of know which one to give the most of. What I typically do, I start with a balanced methylator and I see what their homocysteine does. If I’m not getting there then I’ll order a methylation profile and start looking at all the enzymes and then you can attack it directly.

Dr. Weitz:                          Okay. Good, good, good. So, I’d like to bring up TMAO. This is a marker for heart health that was developed by Dr. Stanley Hazen from the Cleveland Clinic.

Dr. Houston:                      Yeah, so TMA and TMAO, we’ll distinguish what those are, trimethylamine is a product that you get primarily in carnitine, maybe phosphatidylcholine, and then the bacteria feed on that stuff and they convert it to TMAO which is trimethylamine oxidase. That’s a conversion in the liver. So, the TMAO has been associated with blocking reverse cholesterol transport along with other atherogenic effects. As Dr. Hazen felt that it was a risk factor for atherosclerosis and therefore you should limit the consumption of things that cause TMA to go up.  Well, there’s a lot of controversy about that issue as well, whether it’s cause and effect or whether it’s just an association. But if you do consume a lot of carnitine and a lot a PC in your diet, you can raise TMAO. It’s no question about it. But then there was a study for Mayo Clinic, because you know they’re always butting heads with Cleveland Clinic, and they found that if you took carnitine you reduce your risk of heart attack even though your TMAO may have gone up.  So you’ve got to balance all this stuff out. What I typically do, I measure…

Dr. Weitz:                          And we know that L-carnitine is super beneficial for the heart, right?

Dr. Houston:                      Absolutely. Yeah, particularly in heart failure. So, it’s not that you don’t want to use it and then you’ve got a balanced TMAO, but what I typically do if the TMA goes up, I’ll put them on a primarily plant-based diet for about a week or so. Kind of get them cleaned up, give them some probiotics, some prebiotics, and then try to get everything back to what I want to. Because I use a lot of carnitine, taurine, and D-ribose in my heart failure patients. And if you stop the carnitine, for example, because that’s transporting the long chain fatty acids into the mitochondria for beta oxidation you could end up causing them to do not so well.

Dr. Weitz:                          And cold water fish contains high levels of TMAO.

Dr. Houston:                      It does.

Dr. Weitz:                          And we know how beneficial fish is and how it lowers your risk for heart disease. So, this whole TMAO thing really doesn’t seem to accord with all the other things we know. Also, you’re talking about choline. And we know how beneficial choline is for liver health, brain health.

Dr. Houston:                      Yeah. I’m not sure I buy totally into the TMAO issue yet, because there’s too many benefits of the things you just mentioned, balanced with the studies of fish. You know that doesn’t pan out. So I don’t know really what the story is. [inaudible 00:36:38] find out about.

Dr. Weitz:                          Well one way that some people have analyzed it is the TMAO is produced by the gut bacteria.

Dr. Houston:                      Right.

Dr. Weitz:                          It may just be a marker for having an unhealthy, dysbiotic gut.

Dr. Houston:                      Exactly. If you’ve got dysbiosis and the wrong bacteria in there, if you clean up the gut, and that’s generally what a plant-based diet will do. It’ll convert very quickly, usually a couple of days. Get your microbiome cleaned up. The next time you challenge them with PC or carnitine their TMO won’t go up. So, I think the dysbiosis is a good explanation for it.

Dr. Weitz:                          Okay, so now you’ve just mentioned the vegetarian diet. Now the question is, what is the best diet to lower your risk for heart disease? Is vegetarian diet better, Mediterranean diet, ketogenic diet, or does it depend on each person?

Dr. Houston:                      If you go by science of published data there’s no question a Mediterranean diet is the best for heart disease, and diabetes, and other issues. And it’s not a vegetarian diet, it’s a plant-based diet meaning you eat a lot of vegetables and fruit. That’s at your base of your so called pyramid. But you also eat meat, particularly fish. You just cut out all the refined carbs. A lot of omega-3s, and MoFAs, and olive oil, and nuts in the Mediterranean diet. So that’s what I tell people to do most of the time. Then we’ll throw in some fasting mimicking diets, some fasting stuff, and we get great results with everything doing that.

Dr. Weitz:                            Okay. So when I’ve looked at some of the studies on the Mediterranean diet one of the confusing things is it’s a little fuzzy exactly what it includes. I mean, we all know about olive oil, and fish, and fruits, and vegetables. But other than that, is bread included? Is pasta included? Is there a lot of legumes? What about cheese and dairy products? And if you look at the different studies they all have different criteria and this may partially be because it depends on which part of the Mediterranean, is there really a Mediterranean diet?

Dr. Houston:                      Yeah, you’re exactly right. When you say Mediterranean you have to define what Mediterranean diet. Is it the one they use in Spain, or Italy, or somewhere else? Greek?

Dr. Weitz:                            Right.

Dr. Houston:                      Sometimes it’s better not to name our diets, it’s better just to say, “Here’s what I want you to eat.” So, let’s just do that. 10 to 12 servings of organic fresh fruits and vegetables a day. Mostly vegetables, 8 to 4. That’s the ratio, okay? High quality organic meat, cold water fish, salmon, mackerel, cod. Complex carbohydrates, get away from refined carbs. That’s usually anything white like bread, pasta, white potatoes, and white rice. And just make sure that your percentages of those things, a lot of monounsaturated fats, olive oil, and nuts, and a lot of omega-3s both in your diet but also as a supplement. Because you just don’t get enough just taking the food probably.

                                                So if you do that you don’t really do a ketogenic diet, which is another thing I don’t recommend because it raises your lipids, and causes inflammation, and it’s just not a healthy diet for heart disease. If you’ve got a brain problem, yeah, maybe different. The problem is when you do the ketogenic diet a lot of people get their saturated fats and other fats up really high and then they don’t get everything else balanced.

Dr. Weitz:                            Interesting. So, patients who are heterozygous or homozygous for ApoE4, I often hear people talk about they need a special kind of diet from everybody else. What’s your opinion about that?

Dr. Houston:                      Yeah, the ApoE4 or E4 are the ones that have a high risk for coronary heart disease and Alzheimer. The do have a differential response to what they eat, particularly different types of fats. And those are the ones who can really have a dramatic effect, particularly with saturated fats. So in that case I would really augment them with omega-3s and monounsaturated, maybe reduce their saturated fats a little more. Definitely keep them off long chain fats and no trans-fats at all, zero.

Dr. Weitz:                          Now, is that a group that you might put on a vegetarian diet?

Dr. Houston:                      Yeah. Yeah, you could do that.

Dr. Weitz:                          Okay. So you’ve also written about micronutrient deficiencies that can play a role in heart disease and for those not in the functional medicine world that seems a really strange idea.

Dr. Houston:                      Yeah, right. So, most people are micronutrient deficient in something if you check it. Let’s just pick one of the micronutrients that’s really common, magnesium. Magnesium’s like 400 biochemical pathways. You say, “Well, would you rather treat every 400th pathway with something or just give them some magnesium and be done with it?” Well, how do you know if their magnesium’s low? Well, you’ve got to measure it. And as you know, magnesium is primarily inside the cells so if you measure just regular blood magnesium you don’t know what their magnesium content is.  So, we measure intracellular magnesium. And we use a company, called SpectraCell which has the micronutrient testing. It measures your intracellular levels in a functional way, which is much better than the so-called bell shaped curve, because how do you compare to somebody else? If you measure your own lymphocytes and what they need to be adequately functioning based on repleting micronutrients that’s missing.  About 30 things they measure. We do this in everybody because it really fits right in with the disease. I’ve seen this happen over and over again. They come in and they’ve got high blood pressure and they’ve got like five deficiencies missing, and we just replete their micronutrients and they’re blood pressure goes to normal. I mean, it’s pretty simple.

Dr. Weitz:                          Amazing.

Dr. Houston:                      Yeah.

Dr. Weitz:                          Yeah, so with this understanding of heart disease you mentioned immunological reactions, and inflammation, which is an immunological factor. Essentially, part of heart disease is really an immunological mediated, really an autoimmune disease. And then when we start thinking about the other diseases, you know, the major diseases, the chronic diseases, we know that cancer is immunologically mediated. We’ve got all these autoimmune diseases that are on the rise and even when you look at gastrointestinal conditions Dr. Pimentel has recently shown that IBS, which is one of the most common conditions has an autoimmune component. It’s apparent that you really need to take a broader approach, to use a Functional Medicine approach if you really want to address heart disease.

Dr. Houston:                      Exactly. I tell everybody if you understand cardiovascular medicine and vascular biology, it crosses all the boundaries. Because those three finite responses, inflammation, oxidative stress, and immune dysfunction, as you mention every organ has those finite responses. So, in essence inflammation in the brain, inflammation in the heart, those two circuits connect very quickly. And then the gut connects to the cardiovascular system. If you don’t get everything kind of lined up and get all those three finite responses in control, you’re not going to do well.

Dr. Weitz:                          Okay. So we’ve talked about diet, we’ve talked about advanced lipid profiles, I’d like to use some of our time to talk about nutraceuticals. The use of targeted nutritional supplements. What are the best supplements to use to reverse plaque in the arteries?

Dr. Houston:                      We’ve done now for the last 10 years a protocol for plaque reversal and plaque prevention, but also we can now reduce coronary calcium score, which people used to think you couldn’t do. But we’ve documented you can.

Dr. Weitz:                          Really?

Dr. Houston:                      Here’s what we do, omega-3 fatty acids, and you’ve got to get high doses. Four grams, five grams a day and it’s got to be a high quality that’s balanced. DEHA, EPA, GLA, and gamma-delta tocopherol. Second is a compound that’s got nitrates in it. You can get a nitrate compound like Neo40, beetroot extract, whatever, but it’s a beet compound. And that supplies nitric oxide through a different pathway, very different from arginine.

Dr. Weitz:                          Okay.

Dr. Houston:                      Kaolic garlic has been studied at UCLA and vitamin K2 MK-7.

Dr. Weitz:                          Okay.

Dr. Houston:                      Now, the recent study has shown that you need a minimum of 360 micrograms a day.

Dr. Weitz:                          360?

Dr. Houston:                      360, that’s the new number.

Dr. Weitz:                          So, we’ve been underdosing.

Dr. Houston:                      Yeah. Get a good quality, get it to that dose. There’s a couple of other things we use. There’s some very specific probiotics, Lactobacillus rhanmosus is good. And then luteolin, lycopene. There’s about six things that clearly reverse plaque. There’s a few things we’ll throw in for other people that have soft plaque versus hard plaque. But if you do that basic program you’re going to see some reversal.

Dr. Weitz:                          And so you mentioned coronary artery calcification scan. What percentage of patients… So, if you have a high score on that, for sure that indicates you have plaque. But let’s say you have a low score. You could still have plaque that’s just not calcified, right?

Dr. Houston:                      Yeah, so let’s talk about that because it is very confusing. A high coronary calcium score, CAC, means two things. One, you’ve got calcium in the arterial wall, or you’ve got calcium in a plaque that’s obstructing. You can’t tell which of those two it is based on the score.

Dr. Weitz:                          So you can have calcium in an artery wall that’s not part of a plaque?

Dr. Houston:                      That’s right. And that’s where you don’t know how to predict whether they’re high risk for obstructive coronary heart disease and you have to do additional tests to find out.

Dr. Weitz:                          So why would a coronary artery have calcium in it if it’s not…

Dr. Houston:                      Well, it’s aging of the artery number one. It’s got micronutrient deficiencies like the ones we mentioned, K2 MK-7, D, and A. That’s calcifying arteries but your bone’s not calcified, so those two are at the opposite extremes.  So when you see a calcium score that’s high you’ve got to to the next value and say, “Okay, is it in the artery or is it just in the wall?” And you do echo, exercise EKG, nuclear scans, or you can do an arteriogram to find out.  Now, you’re right on the other one too, which is if your calcium score is zero or low, it doesn’t mean you don’t have heart disease because it may not be calcified in the artery… I mean, in the plaque. So, I’ve had a couple people who’ve had like 95 block in their LAD and they had a 0 calcium score. But it was soft plaque, it hadn’t calcified yet.

Dr. Weitz:                          Can you explain what the LAD is?

Dr. Houston:                      It’s the left anterior descending artery, it’s the widow maker. That’s the one that supplies the inferior lateral part of the heart. If it goes out, you’re gone.

Dr. Weitz:                          Okay. So, how effective is red yeast rice for improving our cardiovascular risk?

Dr. Houston:                      Red yeast rice is a great product and we use a lot of red yeast rice. Again, you’ve got to have a high quality because a lot of its come in from China and it’s spiked with something. A lot of companies don’t make the high quality.  If you get a good quality, though, it works like a charm. We use really high doses in people that are like statin intolerant or just refuse to take a statin. 

Dr. Weitz:                          What do you consider high dosages?  

Dr. Houston:                      High dosages is 4800 mg per day. And we use it with berberine and some other things to enhance the effect.

Dr. Weitz:                           Tocotrienols?

Dr. Houston:                      … LDL particle number and they say, “Hey, look, I can’t take a statin because my muscles ache.” If I get them on high dose red yeast rice, berberine, a phytosterol, and some niacin I can get their LDL particle number down 50%, which is what most of the drugs will do.

Dr. Weitz:                            Wow.

Dr. Houston:                      And there’s actually data that red yeast rice will primarily prevent a heart attack and also secondarily prevent another heart attack if you’ve already had one. So the data’s there. And actually The Annals of Internal Medicine has written a couple articles that it’s a good alternative to statin if they can’t take it.

Dr. Weitz:                            Now, some people say that red yeast rice is really just a natural version of a statin, and if you’re going to be intolerant to a statin you’re going to be intolerant to red yeast rice. If you don’t want to take a statin, why should you take a red yeast rice? Can you answer that question?

Dr. Houston:                      Yeah, and none of those are actually true statements. Red yeast rice was the compound that Merck Pharmaceutical used to make lovastatin. But what they did, they took everything out except one thing. So, red yeast rice is a lot more than just a statin. Statin is in red yeast rice but it’s not the whole answer. So, when you give a statin, you’re giving just that piece. If you get red yeast rice, you’re giving a whole composite of things that are going to help cholesterol, but also heart disease. Red yeast rice actually reduces aneurysms. It’s anti-inflammatory. I mean, it does a huge number of things.  So, red yeast rice is not a statin, perse. When you give high doses, because it’s not just a statin you don’t get the same side effects you get with a statin. Rarely, even at that 480 milligram dose do I get any muscle problems. I almost never get a liver problem. It’s very well tolerated.

Dr. Weitz:                          So, do you always use CoQ10 with red yeast rice?

Dr. Houston:                      I use CoQ10 because anything that remotely smells, looks, or tastes like a statin, it’s going to lower your CoQ10 through that pathway. Particularly when you get to high doses of anything. So you give a CoQ10 with it. What you do is you measure their CoQ10 level before treatment, and you start measuring it. I like to keep the CoQ10 over 3 micrograms per deciliter. That’s what’s really normal, lab’s it’s all over the place. But, obviously, if it’s not above that level, or it starts to drop, you need to give them CoQ10. And it’s not just CoQ10 that gets depleted by statin, there’s 10 things that statins deplete. So you’ve got to measure all this stuff and then treat it. That’s why in traditional medicine, most cardiologists, lipidologists, they give statins and they don’t even know if they deplete 10 nutrients.

Dr. Weitz:                          What are the 10 nutrients that get depleted?

Dr. Houston:                      You’ve got CoQ10, vitamin E, omega-3 fatty acids, tocotrienols, carnitine, vitamin K2 MK-7 and vitamin K in general, vitamin A, Heme A, selenium. I think that’s 10.

Dr. Weitz:                            Wow.

Dr. Houston:                      Yeah, and they all go down depending on the dose.

Dr. Weitz:                          Amazing. You mentioned plant sterols. Now, one of the companies that’s doing advanced lipid testing is measuring whether you’re a cholesterol absorber or a producer.

Dr. Houston:                      Yeah.

Dr. Weitz:                          And they’re doing this by measuring levels of plant sterols. I’m a little confused if plant sterols are still a good idea as a result of looking at some of that data.

Dr. Houston:                      Yeah, we used to do that and try to base our treatment on that. It never did really work very well.

Dr. Weitz:                          Okay.

Dr. Houston:                      Let me tell you why. If you’re a hyper-absorber and I block the absorption, guess what? The liver starts making more cholesterol. Now you’re a hyper-producer. If you’re a hyper-producer and I block that, guess what? You start reabsorbing more. So, you’re chronically chasing your tail. Best way to treat those people is to just go ahead and block both pathways.

Dr. Weitz:                          Interesting.

Dr. Houston:                      Yeah.

Dr. Weitz:                          Meaning it would be helpful to use something that reduces the production of cholesterol by the liver, like red yeast rice, and then also use something like a plant sterol that helps block the absorption of cholesterol.

Dr. Houston:                      Or berberine. Because you know berberine is great to block cholesterol, plus you get a lot of other great benefits. Did you know that berberine is an actual natural PCSK9 inhibitor? You can go out and buy Repatha for $11,000 a year or you can buy some berberine for 30 cents a day.

Dr. Weitz:                          Yeah, berberine is amazing.

Dr. Houston:                      It’s amazing.

Dr. Weitz:                          It also goes head-to-head with metformin. I use it as an anti-aging agent.

Dr. Houston:                      Yeah. Well, it does. It actually turns off TOR. So, it does everything that you just said plus a lot more. It turns on AMPK as well, which is good for the metabolic pathway and aging.

Dr. Weitz:                          Interesting. So we talked about tocotrienols a little bit, but I also use them with the red yeast rice or if the patient’s taking a statin, tocotrienols will enhance the effectiveness of that, right?

Dr. Houston:                      They do. The tocotrienols are phenomenal agents and I think probably everybody ought to be taking those. But here’s how they work for cholesterol, they block production of the HMG-CoA enzyme for the messenger RNA. And then the other side they break down the increased catabolism of the enzyme.   So it’s not a competitive inhibitor of HMG-CoA reductase. It actually reduces the increase that you get when you get red yeast rice or statin. So, you get about another 10% decrease in LDL, LDL-P, they’re given a gamma-delta tocotrienol at night with whatever you want to because production tends to be higher at night.

Dr. Weitz:                          Interesting. So you’ve mentioned niacin as a beneficial agent. I’ve had a number of discussions with primary care doctors and they all tell me, “Oh, no. Niacin doesn’t do anything. There’s no benefit.” Why is there so much controversy about niacin?

Dr. Houston:                      Well, niacin got a very bad rap when two large clinical trials came out a few years ago. Joe Pizzorno and I, and several others, Mimi Guarneri, wrote scathing articles back to the journal saying, “Your studies were terrible. You’re misleading people. You have not put the nail in the coffin of niacin by any means. Here’s the reason and you should still be using it.”  So let me tell you first of all, continue to use niacin. It works. And the reason it works is multifactorial. It not only makes every lipid parameter better, I mean, if I do an advanced lipid profile on you everything I measure, niacin improves it. Everything. There’s not one thing that goes wrong including functionality of HDL.  And then the only downside to niacin is if you get really high doses you might increase your blood sugar, you might increase your homocysteine, you may flush, get a little rash, whatever. But typically you can give a lower dose of an intermediate acting niacin and get really good effects that are beneficial for atherosclerosis. So, everything prior to these two inappropriate reports that had bad methodology, niacin worked great, so keep using it. Just be good to get a good quality.

Dr. Weitz:                            Yeah, I think one of the reports, one of the studies used niacin along with a drug that blocked the flushing effect.

Dr. Houston:                      Exactly. That was Merck’s multi-billion dollar drug, and the drug didn’t work. It was supposed to stop the flushing. I’ll say this now because I can get away with it because the published study’s out there. The drug that they had used, they had done studies in experimental animals that suggested that it increased atherosclerosis.

Dr. Weitz:                          Wow.

Dr. Houston:                      Now, they never said that and they weren’t about to say that it does in humans because it was an animal study. But it was a little bit, dare we say, deceiving.

Dr. Weitz:                          Yeah. So soluble fiber, there was a lot of talk about soluble fiber, and I should eat oatmeal. What’s the word on soluble fiber?

Dr. Houston:                      You should eat a mixed fiber. Soluble and insoluble. We never really understood why fiber works so great for everything, but as you notice it works through the microbiome. Fiber literally gets rid of a lot of the dysbiosis, bacteria use it to make great chemicals to reduce diabetes, and heart disease, and blood pressure, and cholesterol. Those little rascals do a lot of good job for us if we keep them healthy.

Dr. Weitz:                          I guess the thought was that the soluble fiber would glom on to the cholesterol and take it out of your system.

Dr. Houston:                      Well, it might do a little bit of that but it turns out that it’s probably most if through the microbiome.

Dr. Weitz:                          Right, okay. Great. Awesome. So, I think that’s the questions I had on my mind. What would you like to tell our audience in terms of closing thoughts, and then in terms of getting a hold of your books and or signing up for some of your programs?

Dr. Houston:                      Excellent, thank you for asking. All of the books that I’ve written are on Amazon so they’re easy to find.

Dr. Weitz:                          And Barnes and Noble I’m assuming, as well?

Dr. Houston:                      Yeah. They’re at bookstores, Amazon. The newest one that’s coming out is really incredible, up to date text book of cardiovascular integrated medicine. As you know precision and personalized medicine is the keyword now for everything. But we’ve got like 35 authors, I did the editing on the book. And it’s the who’s-who of their specialty.  If you’re a healthcare provider, this is the book for you. Watch it coming out, it’s Wolters Kluwer, probably December. Educate yourself. Get the books and read them. But the second thing I would say to you today is come to some of the conferences that we do. A4M, American Academy of Anti-Aging Medicine. We teach an advanced cardiovascular course. We also teach sort of an entry intermediate course as well. But Module 16 is the advanced course, and it’s basically like a masters degree. We’re giving dual certification now for people that complete all four modules. It’s like getting a masters from a university.

Dr. Weitz:                          Okay.

Dr. Houston:                      That one’s good. The other one we do at A4M is Module 2, which is kind of the intermediate cardiovascular course. The advanced course is four 24-hour courses.

Dr. Weitz:                          Wow.

Dr. Houston:                      So it’s four weekends at 8 hours a day for three days. That’s 96 hours.

Dr. Weitz:                          Wow.

Dr. Houston:                      The other module, which is sort of an intermediate course is one three day module that’s 24 hours. You could come in depending on your level of expertise to either one of those. We’d love to have you at A4M for those.

Dr. Weitz:                          That’s great. Are you still teaching for IFM, as well?

Dr. Houston:                      Not so much with IFM as I was 15, 20 years go. Still do a lot with AIHM, Mimi Guarneri’s group out in San Diego, which I’m sure you know about. And also with The Natural Medicine Conference that they do also in San Diego.

Dr. Weitz:                          Great, awesome. Thank you Dr. Houston.

Dr. Houston:                      My pleasure. Thank you, Ben.

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Peptides with Dr. Kathleen O'Neil-Smith: Rational Wellness Podcast 130
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Dr. Kathleen O’Neil-Smith discusses Peptides with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Itunes, so more people will find The Rational Wellness Podcast. Also check out the video version on YouTube at https://www.youtube.com/user/weitzchiro/]

 

Podcast Highlights

3:35  Peptides are signaling molecules. They are bio natural and are not pharmaceutical agents.  If you have a patient in pain, you don’t want to treat the pain, you want to treat the cause, which is what peptides help you to do.  Peptides communicate with our cells and sometimes they enter the cells through pinocytosis and they signal the cell to function better along with the other cells around it to function as a team.

8:07  Most peptides are prescription medications and taken through injection, except for BPC 157 (Body Protective Compound 157) and AOD (Anti-Obesity Drug), which we are focusing on today.  Dr. O’Neil-Smith emphasized the importance of purchasing peptides from a reputable source like from a doctor or chiropractor instead of from China through the internet.  She explained that AOD is a fragment of growth hormone and its action is lipolysis. If you take growth hormone, this can increase glucose and cause insulin resistance, which is not desireable. But when you use AOD, you don’t get these effects. Dr. O’Neil-Smith explained that AOD is effective in conjunction with hyaluronic acid and can be injected into joints to make those joints function more smoothly and to be more elastic. 

11:21  BPC 157 is available in an oral, over the counter form, and also as an injectible and the benefits are potentially amazing and protects the body from many things.  It was first discovered in the gastric juices and it has great utility in the gut.  Dr. O’Neil-Smith explained that if you were to sever the gut or if you were to take a gut and tie a rope around it, you would get a necrotic gut.  If you then take that rope off after three days and you let that necrotic gut sit there and you bathe one half of the necrotic part in BPC and you bathe the other half in saline, 10 days later the gut bathed in BPC grows back.  BPC can be very beneficial for inflammatory bowel disorder, such as in Crohn’s and ulcerative colitis, where it can heal a fragile, bleeding gut and bring it back to health.  If the patient is having an acute flare, it is best to both use oral and subcutaneous injection of BPC.  An oral dosage of 500 mg three times per day would be a good dosage at first to load up, but she noted that there is no reason why you could not take a higher dosage. She also uses it a lot in brain injuries, such as concussions or CTE. 

18:00  Dr. O’Neil-Smith often uses BPC for injuries in athletes, including professional and Olympic athletes.  She notes that BPC is not on the WADA list of banned substances.  While peptides can help heal injuries, they do not provide a boost the way that supratherapeutic levels of testosterone or other anabolic hormones do.  Peptides are bio natural regulatory signaling cells allowing the body to use the body’s own healing properties instead of medicines or drugs. 

22:56  BPC-157 works on multiple pathways in the nucleus of the cell directing the silencing of genes that continue inflammation and promoting the genes that direct blood vessel, connective tissue, fascia, and nerve repair.  BPC is very restorative and regenerative and even stimulates autophagy.  Dr. O’Neil-Smith said that with her patients they need to be taking in the essential nutrients, either orally or through IV.  They need to do either intermittent fasting, time-restricted eating, or the fasting mimicking diet.  They need to have the proper balance of hormones. And then to give peptides makes the most sense.  She also likes to use therapies like sound wave or shock wave therapy to break up the granules and scar tissue to stimulate healing in her office.

31:46  Some of the research indicates that BPC-157 facilitates growth hormone being able to help tendons to heal. (Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.) Dr. O’Neil-Smith said that for growth hormone facilitation she tends to use CJC 1295 (a synthetic analogue of growth hormone-releasing hormone (GHRH)) and IPA (Ipamorelin) peptides. Dr. O’Neil-Smith explained that using growth hormone is expensive, it requires carefully monitoring insulin levels and using insulin injections, and it will shut down your brain’s production of growth hormone.  There is also a high potential to abuse growth hormone.  CJC and IPA can be used for patients recovering from surgery such as an achilles tendon or an ACL repair.  They can also help with the healing of plantar fascitis and similar conditions.  Dr. O’Neil-Smith uses peptides for recovery from surgery and also for re-regulating insulin signaling, which can be helpful for diabetes and also for weight gain. For an injured achilles tendon she will inject BPC around the tendon and this has been shown in studies. 

39:19  Dr. O’Neil-Smith’s stack for post-surgical recovery in some patients would be BPC, CJC, and HCG, (human chorionic gonadotropin), though she points out that she practices individualized medicine and her recommendations for each patient will be different.  She explained that HCG has a number of benefits, including stimulating testosterone utilization receptor uptake, as well as for repair and regeneration in other ways. 

44:10  BPC can be used to heal the gut, for wound healing, for regeneration of nerves, and for concussion recovery.  It is being researched for its benefits for Multiple Sclerosis. 

46:22  For anti-aging benefits, Dr. O’Neil-Smith recommends the following:  1. BPC-157,  2. Omega 3 fish oil,  3. vitamin D,  4. vitamin K2,  5. NAD  (such as nicotinamide riboside),  6. Resveratrol,  7. Curcumin,  8. NAC,  9. Probiotics.

 

       



Dr. Kathleen O’Neil-Smith is an MD with her practice focus on Functional and Regenerative Medicine. She completed a stem cell certification through the A4M.  She is an international thought leader in the clinical use of peptide therapy and she healed her son from a severe TBI with peptides.  She can be contacted through her website Treat Wellness, LLC.  She is now training other doctors through her Peptide Master Class that you can find on her website. 

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111 or go to www.drweitz.com.



 

Podcast Transcript

Dr. Weitz:                            This is Dr. Ben Weitz with the Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to Rational Wellness Podcast on iTunes and YouTube, and sign up for my free e-book on my website by going to drweitz.com. Let’s get started on your road to better health.  Hello Rational Wellness Podcasters. Thank you so much for joining me again today. For those of you who enjoy listening to the Rational Wellness Podcast, please go to Apple Podcast and give us a glowing review and ratings. That way more people find out about the Rational Wellness Podcast. For those of you who’d like to view this podcast, go to YouTube and you can see a video version.  If you go to my website, drweitz.com, you can find detailed show notes and a complete transcript.

Today our topic is peptides with Dr. Kathleen O’Neil-Smith. Peptides are short chains of amino acids that are connected by peptide bonds, but they are shorter than proteins. The general rule is that a protein contains more than 50 amino acids. Insulin is generally considered to be the first peptide discovered, but it actually has 51 amino acids, so apparently that’s not a hard and fast rule.  Peptides are just generally shorter and proteins are bigger. Peptides have many functions in the body but some function is hormones and signaling molecules and regulators of various metabolic processes in the body. There are peptides that can have a significant effect on memory and cognitive function, weight loss, muscle growth, immune modulation, gut health, sleep, and anti-cancer, among other effects.

Today we’re going to focus most of our discussion on BPC, body protective compound 157, and it has benefits for healing of soft tissues like tendons, nerves, as well as the lining of gut, and many other tissues in the body. Dr. Kathleen O’Neil-Smith is a magna cum laude graduate of the Boston University School of Medicine. She also has a degree in exercise physiology and she was an athlete on the national rowing team for 39 years and then was a coach for six years. Her current practice is focused on functional and regenerative medicine, and she completed a two year fellowship on this.  She also recently completed a stem cell certification through the A4M American Association of Anti-Aging Medicine. She’s also an international thought leader in the clinical use of peptide therapy, and she healed her son from a severe brain injury with peptides. Thank you for joining us today, Dr. O’Neil-Smith.

Dr O’Neil-Smith:               It’s good to be here. It was nice to see you at the conference in Seattle six weeks ago and to keep in touch, and to know that I’ll be seeing you again at your place in Santa Monica.

Dr. Weitz:                         Cool. So what are peptides?

Dr O’Neil-Smith:               Well peptides are signaling molecules. They’re a means of treatment. They’re bio natural. So when I think of the body, I think that there are many ways to heal it. Conventionally, as an internal medicine doctor, I used to think about pharmaceutical agents, but pharmaceutical agents are generally not helping the body to rebuild. They’re basically treating a symptom. So you can take a blood pressure med and you can reduce blood pressure but that doesn’t treat the root cause.  The medicine that we use is not something that was bio natural to the body. When we think of peptides … when I think of the way I want to treat the body, I want to treat the root cause. I don’t treat pain. You’re a chiropractor. You may see some pain. You may see some brain … some brain injury. You may see some concussion. You may see some joint injury. You never treat pain. You treat the cause of the pain.

                                         If you just treated pain, you’d give them Oxycontin, right, and we have an opioid crisis. If you want to treat the cause of the problem, you have to understand whether it’s structural, mechanical, or functional, or both. Generally it’s both because even if you got an injury that’s structural, right? Even if you got a torn labrum in the hip or in the shoulder, you’ve got a structural problem, but you also have a functional problem.   The functional problem is all the fire alarms and the molecules that are released from that joint problem. When they’re released from the joint problem, the cells start to have crosstalk between them and they signal each other, inflammation, fire, and it’s like fire alarms going off, like in a fire in California, in many different counties.

                                         When we use a peptide as opposed to a medicine, a peptide works as a fire alarm, but to put out the fire it’s natural, as I said, generally speaking. They occur in the body naturally and they occasionally in varying amounts at varying times. As a fire alarm, it goes cell to cell to cell saying, “Hey, this inflammation in here,” in the joint pain for example, the labrum injury. “We’re going to come together. I’m going to do my job as one cell to resolve this inflammation and repair without scar, without fibrosis, without making the tissue more dense, the fascia tissue more dense. I’m going to heal this appropriately. I’m going to regenerate this tissue appropriately, and I need all you other cells around me, the fire departments, to get on board and to do your job.”  That’s called autocrine signaling where one cell tells itself how to do the right thing and not just be a runaway inflammatory cell that becomes scarred, and paracrine signaling that tells the cells around it, or the departments around it, “We’re going to work together to pull this in and not get scarring, but to get healing, as full function back as we can of that particular injury.”

Dr. Weitz:                         And paracrine is essentially another word for hormones, right?

Dr O’Neil-Smith:               No, I mean paracrine … hormones are very kind of more direct. If you use a hormone like an estrogen and progesterone, testosterone, male or female, whatever, and you give someone a hormone, which I’m all in favor of if they’re bio natural, and we need to restore balance, and that’s a whole other topic on fascia that’s fascinating, and the receptors in fascia, the hormone receptors in fascia. But at any rate, the hormone will attach to that cell on a membrane in a receptor and it will go create this whole internal effect within the cell and go to the nucleus and the gene and get inaction.  So if you use testosterone, an action is to increase libido or to increase muscle mass, a muscle, to grow back a muscle. If you use a peptide, peptides actually enter the cells in different ways. They don’t always attach to a receptor on the cell’s surface. They pop into the cell like a dart. They get into the cell with something called pinocytosis, and then they will cause this whole signaling effect, and it’s really cool. It’s a little bit different. So we call them signals, cell signaling molecules, molecules that signal the cell that they’re near and all the cells around it within that tissue, within that organ, to function as a team.

Dr. Weitz:                         Cool. So are peptides prescription medications or are they over-the-counter like nutritional supplements?

Dr O’Neil-Smith:               Both, both. Many of them … most of them are prescription medications, but the ones that we were thinking to focus on today are over-the-counter and there are supplements that you can get … I certainly wouldn’t buy them from China because you don’t what you’re getting. I would buy from a reputable source like a doctor, a chiropractor, an acupuncturist, whatever, who knows that they’ve gotten them from a reputable source.  BPC and AOD are the two peptides that are available pretty readily, and those are all over social media right now because they’re very, very effective.

Dr. Weitz:                         What is AOD?

Dr O’Neil-Smith:               AOD is anti-obesity drug. That’s really not a great name for it. It’s a peptide. It’s a little fragment, a small fragment, of growth hormone. Growth hormone … I used some slides. I’m not sure if you have them, but growth hormone … and AOD was on that. Growth hormone is about 200 amino acids which contains the peptide. AOD is a fragment of growth hormone, so it would be under 50 amino acids, so it’s 15 or whatever it is amino acids.  So that particular fragment of growth hormones has particular actions, and the action of AOD is lipolysis. So breaking down fat, which is really desirable. Growth hormone as its whole can increase glucose and can cause some insulin resistance and that’s not desirable. When you use just the AOD fragment, you don’t get the insulin resistance. You don’t get the elevated glucose and you don’t get fat deposition.  When you use AOD you get breakdown of fat, metabolism of fat, so fat loss. The other really … I don’t use a lot of AOD for that particular purpose, but you can. I do have some patients that do well with that. The other way that you can use AOD is in joints because it also heals soft tissue and cartilage. So it can come as creams. It comes in many ways but it also comes as an injectable that you can do sub-q or that you can put into joints. You can put with hyaluronic acid, which is very soothing and lubricating for joints, so you get good movement in every direction, up/down, all around, diagonally, you name it. You get the gliding and sliding and elasticity of that joint.  So you can combine AOD and HA, and you can use them together within a joint, and I do that often, often, a lot.

Dr. Weitz:                         Yeah some of the collagen supplements contain HA.

Dr O’Neil-Smith:               Exactly, exactly. But when you put AOD with HA, it’s very beneficial. I love AOD/HA. It has many of the benefits of growth hormone, because it’s a small fragment and not a lot of the downsides of growth hormone. So it’s very, very good.

Dr. Weitz:                         So now BPC-157 is both oral and injectable. Is there an advantage to one over the other in certain situations?

Dr O’Neil-Smith:               BPC is a miracle. I work with-

Dr. Weitz:                         I mean when I got that booklet from Dr. Holtorf and started going through these studies, it was … I mean this is ridiculous. The benefits are so amazing, either this is the new wonder drug or it’s snake oil.

Dr O’Neil-Smith:               No. It’s really not. I can tell you a couple of stories about it.  So I work with another doctor in Florida, Dr. Akey. She’s visited and spent time with the doctor who discovered BPC.  He discovered it in the 1990s and since then he teaches at the Zagreb Medical School, so he has been studying this extensively.  When you visit his lab and you meet him personally, you know he’s the real deal.  When you see the work he does and he shows you within his lab the benefits of it, it literally is miraculous and mind boggling.  It’s funny because in the states BPC is … everybody loves BPC.  It’s called Body Protection Compound 157, thus it protects the body from many things.  It was originally by Dr. Sizgorich in Croatia founded to be in the gastric juices. So where we first understood its utility was in the gut and obviously we found it in the gastric juices. What can it do for the gut? We know that it can heal the gut. I teach a lot on BPC to the stem cell group, to the anti-aging group, to everybody, to a lot of doctors and patients, clients, and the public.  BPC for the gut, if you were to sever the gut … if you were to take a gut and you were to tie a rope around it and cut it off, you get what? Necrotic gut. If you then take that rope off after three days and you let that necrotic gut sit there and you bathe one half of the necrotic part in BPC and you bathe the other half in saline, 10 days later the BPC grows back.

Dr. Weitz:                         Wow. That’s pretty amazing.

Dr O’Neil-Smith:               You can see it grossly looking at it. You can see it under the microscope, and it’s the most remarkable thing ever. So it works in the gut. We use it a lot. I use it a lot in any gut dysfunction. I use it a lot when there’s a brain injury because you’ve heard me talk about the gut. The gut and the brain you heard during that whole series of lectures are directly connected.  So whenever there is an injury in the brain, a concussion, an athletic injury, CTE if you think that you’ve got an ex-athlete who’s really had a lot of concussions. They don’t really complain of a concussion but things are disrupted, I always use BPC in an injury that’s in the brain or in the gut.  If someone has inflammatory bowel disorder, I’ve used it a lot in Crohn’s colitis, in ulcerative colitis, to heal that fragile friable bleeding gut and to bring it back to health.

Dr. Weitz:                         So let’s say you have a patient with Crohn’s or ulcerative colitis and let’s say they see you and they’re having an acute flare. Will you use the BPC right away and if so how much and how long will you use it for?

Dr O’Neil-Smith:               So back to your original question about whether I use it sub-q or oral, in an active flare, in an acute flare, I always do sub-q, particularly … you know we don’t know how well the gut’s going to work if we give it orally. So in a sub-q flare and in an acute flare, you’re going to want-

Dr. Weitz:                         But you want it to go in the gut right? Because the gut’s what’s injured.

Dr O’Neil-Smith:               The gut is what’s injured but the gut is usually injured from the inside out as opposed to the outside in. You quiet down what you deliver to the gut. You quiet down food. You quiet down all of those different things. You might give some nutrients in other ways. Definitely if you’re going to use the gut, use it in a liquid way. Use elemental diet, which is broken down food to keep the calories in, to keep the weight on, but you’re not going to want the gut to have to do a lot of work, so you’re going to want to really quiet the gut.  If you quiet the gut and you give a little BPC, most people tolerate it orally but sub-q … I would attack anything acute from the inside and the outside. I’m coming from all angles. If I’m in a war zone, I’m coming from every angle. If there’s something acute going on, I’m coming from every angle. So I’m always going to, in an acute situation, use a sub-q and an oral. If all you have available to you is an oral, load up. Load up.

Dr. Weitz:                         So how much is loading up?

Dr O’Neil-Smith:               Load up would be certainly multiple times a day. You can’t take too much.

Dr. Weitz:                         For what dosage?

Dr O’Neil-Smith:               Well the dosage I think on an oral, like Dr. Holtorf’s product is about 500. So when you take that 500, you can take that twice a day or three times a day, and you can do that until you feel things quiet down. Then you can begin to reduce and go down to once per day.

Dr. Weitz:                         So 500 is in one capsule. Could you take 1000 three times a day?

Dr O’Neil-Smith:               Why not? Won’t hurt you.

Dr. Weitz:                         I don’t know.

Dr O’Neil-Smith:               Yes, you can.

Dr. Weitz:                         Okay.

Dr O’Neil-Smith:               There’s never been found, in the 30 years that it’s been studied, a lethal dose, or a dose that’s harmful. There’s no lethal dose.

Dr. Weitz:                         And do you get better benefit? What level do you think … Do you think 500 is where you get the maximum benefit or what do you think?

Dr O’Neil-Smith:               No I think it really depends on the person. I think that’s why it’s important to work with someone like you or with a doctor who understands this stuff because they’re going to help you figure that out. I would say that mostly in my practice I have used the sub-q and the oral. If I’m using the sub-q, an injection in the belly, small little insulin needle, a little bit of BPC, I will only do the oral once a day.  If I don’t have any sub-q … if they don’t have it for some reason, they’re somewhere in another country. They call me or talk to me about an injury or something acute, I’ll say take oral one, three times a day. That’s the most I’ve ever had to do. So I really have never had to do that. I might do IV. I mean I’ll do it every which way I can depending upon how significant. If it’s a chronic injury … even with athletes. So I’ve used BPC in a lot of elite-level athletes, NHL, NFL, active athletes.  If you’re going to use BPC and it’s not on the WADA list. I hope it never it is. It shouldn’t be on the WADA list. If you’re going to use BPC-

Dr. Weitz:                         A WADA list is the list of banned substances, right?

Dr O’Neil-Smith:               Correct. If you’re going to use BPC in an athlete, I basically tell them they’re going to need … Well one it’s good in the setting of inflammation. So it’s not like they have to stop playing. They can get the benefit of this and some healing from this even in the setting of inflammation, which is contrary to what most people think. People think that you have to stop … that steroids have to be done and then you use a peptide. No, never use a steroid if you can avoid it, ever, ever, ever. Steroids are like Oxycontin. They put out the signal, which is what pain is. They put out the signal, which is what inflammation is, and they don’t allow for healing. They’re wrong. So what we want to do is use something that will redirect the signal to heal.

Dr. Weitz:                         You say that professional athletes can use them. What about Olympic athletes?

Dr O’Neil-Smith:               Yes, yes.

Dr. Weitz:                         But I don’t think they’re allowed to use any injectable substances.

Dr O’Neil-Smith:               Yeah, no well that’s different. I mean the problem with having been on the Olympic team and coached the Olympic team and all that kind of stuff, I mean I remember, Ben, when I was in the 80s racing the Russians before 1984 when they didn’t show up in Europe. When they showed up and we all went into the bathroom and we had to collect our urine to see if we were on anything, and they passed and got to keep their medals, we were all dumbfounded. I was young then. I was still in college and I thought they’re doing hormones. Why aren’t they being found?

                                          When I learned about peptides six years ago, seven years ago, maybe a little longer … the ones that we’re talking about … I realized they weren’t using hormones. They were using peptides. So peptides … they’re not like hormones. They’re not something you can get supratherapeutic on. Testosterone, if a normal range, let’s pick a number 800. If I give Manny Ramirez testosterone, he can go from 700 to 2500 and be aggressive and whack that ball or whatever right? But that is supratherapeutic levels. You can do that with hormones. You can detect that. you don’t get supratherapeutic levels with peptides. So it’s a whole different ballgame.  These, remember, are more bio natural and they just go in and they do their job silently, quietly. They don’t make you a super human. They just make you able to heal more easily.

Dr. Weitz:                         So but are Olympic athletes allowed to use these injectable peptides?

Dr O’Neil-Smith:               They’re not on the list.

Dr. Weitz:                         They’re not on the list. They’re not even supposed to use injectable vitamins.

Dr O’Neil-Smith:               I know.

Dr. Weitz:                         So I would think the injectable ones would potentially be a problem, right?

Dr O’Neil-Smith:               It depends. It depends on … I have athletes that try for the Olympic team. I would have them go to their staff in NHL and NFL and everything else. They go direct to their person and what their person there will do, and it’s not always the same person. It’s not like the doctor, the athletic trainer, or the nutritionist. It’s whoever it is … whoever their relationship is with. What they’ll typically do is send a sample to their lab and say is this okay?  I would say that 100% of the time it comes back okay.  So I have it tested because I care enough that they are well.  So if I have in the NHL a Boston Bruin who’s had a brain injury or a massive concussion, why would they not be allowed to be treated appropriately?  So we have to begin to bridge the gap with the things that are dangerous, the testosterones that are overly used, the anabolic steroids that are overly used.  These are not anabolic steroids.  These are bio natural regulatory signaling cells allowing the body to use the body’s own healing properties instead of medicines or drugs.

Dr. Weitz:                         How does BPC-157 help with the healing of tendons?

Dr O’Neil-Smith:               BPC-157 works on multiple pathways in the nucleus of the cell directing gene silencing and gene promotion. So they silence the genes that continue runaway inflammation and promote the genes that basically … a lot of nitric oxide enhancements. They don’t just do blood vessel repair.  BPC also does nervous system repair.  When I think of an injury, we all talk about blood vessels.  Well the knee doesn’t have a lot of blood vessels. Joints don’t have a lot of blood vessels.  So it’s not really that we want mostly blood flow there because that’s not a natural state for a joint like the knee.  What we want is the nerve endings to not be inflamed.  For the milieu or the bath or the soup that the nerve endings are bathing in to be appropriate. So BPC is very good at allowing for cleanup and that’s called autophagy. You’ve probably heard a little bit about autophagy. Autophagy is-

Dr. Weitz:                         Related to fasting especially or ketogenic diet.

Dr O’Neil-Smith:               Okay so it relates to everything in the cell because autophagy is auto, self, auto means self. Phagy … phagy is clean up. Clean up yourself. You make a mess in your room, clean it up. You make a mess in your cells, clean it up. It’s naturally occurring housekeeping of a cell. So fasting allows for autophagy or housekeeping because you don’t keep sending in food that needs to be metabolized and creates waste.  Food always creates waste. That’s why we stool. Food in the body, not just in the gut, creates waste. In the cell it creates waste. When we fast we allow for better housekeeping, better cleanup of the gut and of the body. That’s ketogenic, that’s fasting mimicking diet with Valter Longo’s protocol at USC. That’s other protocols for dieting. But with peptides we allow for autophagy as well and we clean up-

Dr. Weitz:                         It’s interesting because my general sense of peptides, and especially since I had found out that bodybuilders are using it and athletes. It seems like when we look at the whole anti-aging continuum, it seems to me anyway … maybe I’m oversimplifying things, that we have this … we have the growth signals and then autophagy is part of the … We’re in starvation mode. The body can’t grow because it doesn’t have the necessary ingredients. So that’s when it starts breaking down its own cells to scavenge the amino acids for protein.  Peptides seem to be as part of the growth stimulation factor is not the starvation factor. So I’m surprised to hear that.

Dr O’Neil-Smith:               Woops oh hang on. Sorry the meeting has been upgraded. Okay. Yeah go ahead.

Dr. Weitz:                         Yeah, am I confusing things?

Dr O’Neil-Smith:               No. When I think about the body I think about catabolism/anabolism. You’re breaking it down. You’re building it up. Most of the things in medicine that we do and that happen every day from the time you wake up to the time you go back to bed … go to bed, is catabolic. It’s breaking you down. Same thing when you go to the gym. You’re breaking down. The goal is to break down and build appropriately back. The goal is to get through the stress … good stress, bad stress, whatever of the day and then restore at night.  We are in a fast paced society. The amount of housekeeping that needs to be done is enormous, completely different … every six months it’s bigger. It’s like the clean up of the environment. It’s big. So the reality is, is that mostly what we do in medicine is we just stop the signaling. We never really give the regenerative potential. We just put out the fire but we never rebuild back. So you’re sitting there with a burned building and you never rebuild it back. You’ve got to restore that.  What peptides do as the … So food and fasting mimicking diets or fasting will just stop the fire. Using peptides, they are regenerative. They’re going to build back with the fire burned. It’s a really important way and I think that the primary thing … You know one of the things that … There’s a lot of systems and there’s a lot we don’t know and a lot of doctors like to keep it very simple and work with what they know. That’s great. Work with what you know and then build on what you know.

                                         So when you think … right now the thing I’m thinking about the most in terms of pain and in terms of joints and in terms of injury, and in terms of a gut injury, a brain injury, whatever it is, my passion is brain and soft tissue injury. Kind of everything. But when you understand fascia, fascia is probably the largest organ in the body. Think about that white bright glistening component on meat and you cut through the layer and you’ve got more and more fascia. You understand this. Fascia is so contiguous and so abundant in the body.  Fascia happens in layers. Between those layers of fascia with the collagen, the different types of collagen, one, two, three, four, you name it. All of the different nutrients that collagen needs, they’re also many. Fascia has hormone receptors. It has receptors for estrogen, for progesterone, for testosterone. Who talks about that? Who thinks about that? We get afraid of giving too much of something but we need the right amount of testosterone, of estrogen and progesterone in men and women in order for that fascia to glide and move in all directions, and to be elastic and to be able to withstand the wear and tear of everyday.

                                                To rebuild that, we also need those signaling molecules because they help to keep the nerves, the free nerve endings in that fascia healthy. So the peptides are one component of many things. I make a pyramid when I treat my patients and I think of a house in the middle of an ocean being battered by a hurricane, then a tornado and whatever. That house is sitting on a rock and that rock has to be solid. That foundation has to be solid. So you have to start with having adequate ingredients available to build the body back, which are nutrients.  Whether you give them IV, whether you give them orally, make sure they’re getting in and make sure that the body is receiving them. To do anything else, peptides and other things, if you don’t have nutrients, it doesn’t make sense. If you haven’t cleaned up with a little fast here and there, it doesn’t make sense. Intermittent fasting, time-restricted eating, a little ketogenic, a little fasting mimicking diet prolong, whatever it is you do, you’ve got to be doing some of that. You’ve got to know you’re getting nutrients in.

                                         The second thing in my pyramid going from top to bottom, foundation is bottom. Foundation here … is how do we use hormones? What is the balance of hormones that we need? You really restore some hormones. It might even be progesterone in a man, a little bit, because that’s going to help that fascia move. They have to have an adequate level of estrogen 20 to 30, whatever it is. It can’t be zero with Arimidex. That doesn’t make sense. Arimidex is going to destroy joints.

                                         After hormones the next thing I would think of is if we have a sound wave therapy machine or something like that to break up the granules that are floating around and wanting to heal you. Those contain some peptide-like molecules. Those granules want to be popped to give you the healing ingredients that you need. So some sound wave therapy if you have that. And if you have access to peptides, oral, over-the-counter, or sub-q, I think those are next. But you don’t want to give peptides like a BPC if someone doesn’t have B12, if someone doesn’t have B1, if someone doesn’t have an antioxidant, if someone doesn’t have a magnesium. Why are you going to give a peptide? You’ve got to know that they’ve got the ingredients for that peptide to work.

Dr. Weitz:                         Yeah and you’ve always got to start with the basics, diet and lifestyle. One of your articles I was reading about BPC-157 and tendon injuries seem to be that it had this positive interaction with growth hormone and it seemed to facilitate the growth hormone being able to help the healing of tendons.

Dr O’Neil-Smith:               Absolutely. It will never be one thing alone. For a growth hormone, I like to use another peptide. I don’t use growth hormone in my practice because of the downsides of growth hormone and because of the abuse around it. You can’t-

Dr. Weitz:                         At one time it was getting to be kind of popular in anti-aging circles but it’s sort of fallen out of favor I’ve noticed.

Dr O’Neil-Smith:               Yeah, yeah, it’s totally out of favor because it can be abused. It’s also very expensive so it’s really hard to maintain. If you’re going to do growth hormone regularly, once you shut down your brain’s production of it, you need to use this. If you’re going to do growth hormone regularly, it’s going to cost you $15,000 a year. You’re going to have a difficult time getting it. It’s going to be very difficult because in order for a doctor to prescribe it in a safe way and in a way that the board regulates, you have to have insulin. You have to have specific testing with insulin, etc. That’s just not something I get into.

                                         But CJC and IPA, another peptide, are peptides that I would consider using. Those are peptides that are growth hormone releasing hormones and growth hormone releasing peptides. They’re a little bit different. GHRH, GHRP, different. So GHRH basically will have some effects of growth hormone and it will regulate that, and GHRP will be more like a ghrelin effect. Similar to BPC because the ghrelin and the ghrelin receptors are throughout the GI tract, because the GI regulates so much of the healing that goes on in our body from the mouth all the way through to the anus.   At each phase of the way, there’s different pH’s. There’s different microbiota or bugs. There’s different utilization of food. Water absorption, etc. So the entire GI tract, not surprising, is releasing many of these peptides as signalers to the rest of the cells around the GI tract. Are we in danger? Are we safe? Do we let this in? Do we keep this out? Is there a bug here? Is there a parasite here? What’s going on and how do I keep the body safe? So GHR-

Dr. Weitz:                         Those are injectables, peptides?

Dr O’Neil-Smith:               Those are injectables. CJC and IPA or GHRH and GHRP are injectable.

Dr. Weitz:                         And you need a prescription for those?

Dr O’Neil-Smith:               You need a prescription and you need to regulate them because there are many ways that you could use them. You could use them for healing a joint if necessary. You can use them for someone who has growth hormone deficiency. You can use them for-

Dr. Weitz:                         For recovery from surgery, say?

Dr O’Neil-Smith:               Absolutely. I always use them in my patients for recovery from surgery. You can also use some of these peptides for insulin signaling to re-regulate insulin signaling because diabetes type 2 and weight gain and adiposity, being overweight, is really a big issue. So we can use these to regulate how the body uses fat for energy, sugar for energy, and make it more efficient.

Dr. Weitz:                         Do you have a combination or they used the word stack in some bodybuilding circles. I’m sure other circles that you would use for say an athlete recovering from Achilles tendon repair or an ACL.

Dr O’Neil-Smith:               Okay let’s take an Achilles. Achilles is amazing. Plantar fasciitis a massive problem. I will absolutely use BPC. I will-

Dr. Weitz:                         And this is post-surgery or even just recovery from an injury without surgery?

Dr O’Neil-Smith:               I’m a big prehab girl. You may pregame in California for your sports games, but I prehab before surgery. That’s kind of a principal that we use anyway. So prehabbing means prepare for surgery. Why would you go into surgery? You wouldn’t go into a game that you wanted to win without preparing for it. Don’t go into a surgery that you want to have a good effect from before doing that. I know for you, your motto is, “For those of you who have no time for healthy eating, you’re going to pay the price later,” right?

Dr. Weitz:                         Right.

Dr O’Neil-Smith:               Find the time now because you’re paying the price later. It’s the same thing for surgery. It makes zero sense to me that you would ever consider a surgery without prehab. So prehab would involve peptides. Now I know the surgeon is going to tell you stop everything before you go in for a surgery. BPC oral is never going to change your bleeding time. BPC oral is going to help it. Stop it for 48 or 72 hours. I have no problem with that. But if someone were going to have an Achilles tendon, BPC alone injected can heal an Achilles tendon. That has been shown in studies.

Dr. Weitz:                         And is it injected around the tendon?

Dr O’Neil-Smith:               Mm-hmm (affirmative). Injected in the tendon. So you can inject it in the tendon. You can inject it …

Dr. Weitz:                         In the tendon or near the tendon?

Dr O’Neil-Smith:               All around. It doesn’t have to go directly in the tendon.

Dr. Weitz:                         Right all around it.

Dr O’Neil-Smith:               Right there. Because remember it’s like the fire department. It’s cell signaling. It’s going to recruit to bring in other cells to do healing. Typically when there’s an injury, and I’ve done this with very well-known athletes, I make a triangle around the injury and I inject around that injury with BPC. You get healing. Even people who are suspicious or suspect realize that they get amazing healing with that. You can also use it at the same time as you do that … I’ve sent people home in the last two days to do the triangulated injection, a little tiny, little bit, just like somebody might do a Botox. That’s a toxin. We’re injecting something that’s healing. It’s a tiny little, just like a Botox needle. Little bit around that, just like they do … I don’t know how they do … I don’t do Botox, but if they did Botox here they’d do … all over. You do that with the BPC and then you put some BPC sub-q, intra-abdominally, no problem. It works together.

                                                It gets the signaling from a distance. It gets a signaling locally. You could do that with insulin. For someone who needs insulin for sugar and they need it to live, when you give insulin in the abdomen, even though the brain cells need it, it gets there. There’s signaling pretty quickly. So you don’t have to put it in the head. You can put it in the belly and it will get where it needs to go. We do that all the time for insulin. Type 1 diabetics who wear pumps, they stick the pump in their tush. They stick the pump in their lower abdomen. They stick the pump in their arm.  No matter where you stick this, it’s going to get to the site it needs, just like BPC.

Dr. Weitz:                            So what would be the stack? You’re going to use BPC-157. What else would you use for somebody who needs recovery from surgery quicker or better?

Dr O’Neil-Smith:               If they’re all in, if they’re all game, I’m probably going to do BPC, CJCE with a growth hormone derivatives, and I might even do HCG, human chorionic gonadotropin, HCG, LH, luteinizing hormone. I would probably do those three. I’ve used that many many times.

Dr. Weitz:                         Do you use HCG even if they have healthy testosterone levels, because HCG is a precursor for … it stimulates your gonads to produce more testosterone, right?

Dr O’Neil-Smith:               Mm-hmm (affirmative) it can increase free testosterone, and the testosterone’s action in the body. I probably would use a little bit, yeah, because HCG … This is where we get trumped up. When you understand that HCG, as you just said-

Dr. Weitz:                         You mean we’re all going to turn orange? I’m just kidding.

Dr O’Neil-Smith:               We’re going to get orangutan hair. We’re going to be the products of orangutan. That’s a joke from I don’t know Saturday Night Live or Larry King Live, somebody. At any rate, Bill Maher. HCG, when we think of it, we think of it as predominantly increasing testosterone. That’s not how I think of the peptide HCG. It does that. It’s one of its actions. I think of HCG as a luteinizing hormone and I think of that as having other benefits in the body that repair and regeneration and growth.

Dr. Weitz:                         Oh really? Oh I never thought of it like that.

Dr O’Neil-Smith:               100%. That’s not what anybody talks about. It’s like if we make … There’s a medical food called DEPLIN. It’s a folate. DEPLIN, methyl folate, has been approved to come on the market for depression. I use methyl folate a lot. My people see that it’s on the market for depression and they don’t want to take it. I’m like no, no, no, no. That’s just what it’s approved for. This has many benefits, and you’ve already felt them. You took it before you knew it was for that, and now you don’t want to take it. This has many benefits. It’s the same with peptides because peptides are what we call pleiotropic. Pleiotropic is if you put the peptide in the middle and you create all of the spokes coming off, it has many spokes, so testosterone utilization receptor uptake would be one spoke for HCG, so I would use HCG as well.

                                                So I would definitely use BPC. I would definitely use a growth hormone derivative, not growth hormone, and I would probably use a little bit of HCG.  I mean there are other things I could use. When I treat a patient, I don’t treat just the condition.  It’s not like you come in and my brain goes, “Achilles injury, boom you get this.” I say, “Achilles injury. How’d it happen? What was the milieu when it happened? Let me get some measurements, prehab, preop. Let me figure out the other things you’re going to use, and that’s going to determine my stack.” I don’t have a one stack. You can’t come in and get a number one in my practice because I treat the patient, not the injury and not the disease.

                                                The injury is a component of the patient, but the injury happened in that patient, so I do personalized medicine where I treat the patient, not the disease with the number one through 10. You don’t get number seven because you have a shoulder injury or a number four because it’s a hip injury. I have to understand why did that injury happen in this patient and those are the things that will help me determine what the stack is going to look like. But within my stack I have nutrients. I have hormones. I have 20 to 25 peptides. I have sound wave therapy. I have exosomes. I have all kinds of different tools and I have to look at the labs for that patient, the biomarkers, to see why did this happen in that patient.  Did they have Marfan syndrome? Were they just on an antibiotic and tore their Achilles? Because levofloxacin, which people will use for a UTI. It’s a bad choice of an antibiotic-

Dr. Weitz:                         For tendons…

Dr O’Neil-Smith:               You’re going to rip your Achilles. I have three patients that that happened to. You’ve got to be careful and you’ve got to think before you use.

Dr. Weitz:                        Yeah all the fluoroquinolones.

Dr O’Neil-Smith:               Right.

Dr. Weitz:                        So BPC can be used to heal the gut. Do you use that as part of your gut protocols?

Dr O’Neil-Smith:               I would say because BPC is so pleiotropic with all those spokes at the wheel and so easy to take and affordable. It’s my number one. It’s my number one. I would say everybody. You can use BPC for a wound. I have a patient, 92-years-old, that had a wound. I had her daughter put the capsule and make a paste and put it on the wound. You can use BPC for a wound. You can use BPC for the gut. You can use BPC for a concussion. It helps to regenerate nerves. It’s being studied presently in MS.

Dr. Weitz:                         Cool.

Dr O’Neil-Smith:               Multiple sclerosis. The initial is that it’s beneficial. So if BPC can heal the brain, why not use it? If BPC is … Ben, three principles whenever you treat somebody, is it safe? Is there a possibility that there’s toxicity? With growth hormone there is. With testosterone there is. There is not with BPC. So is it safe? There’s no toxicity.

Dr. Weitz:                         Are there any downsides?

Dr O’Neil-Smith:               Not that I know of.

Dr. Weitz:                         What about downgrading receptor sensitivity?

Dr O’Neil-Smith:               No indication. So BPC safe. Second principle. Three principles. Effective. Effective therapeutically?  Is it going to help heal?  Is it cost-effective?  I think it fits both, safe and effective, therapeutically and cost-effective.  Then the third question is, is it sustainable?  Will it help to sustainably heal something?  Yes.  So BPC is a no brainer.  No pun intended.  It’s good for the brain. It’s good for the joints. It’s good for a wound.

Dr. Weitz:                         So some people would say hey if I take it all the time and then I have an injury, I might not get a beneficial effect.

Dr O’Neil-Smith:               Well it’s not like BPC is the only thing that’s going to heal an injury. You can change the dosing. If you take it all the time, you might not get the injury.

Dr. Weitz:                         Right so it sounds like this could be part of an effective anti-aging program just to take on an ongoing basis.

Dr O’Neil-Smith:               Yeah so if you were going to think about what are the best anti-aging … or rather than that, the best products that you would use for a health span as opposed to a life span.

Dr. Weitz:                            Yeah I just did a podcast very recently and we talked about that with Dr. Kaufmann. She’s got a whole book on anti-aging. She has really some great protocols there.

Dr O’Neil-Smith:               It’d be interesting to know, but everybody has their favorites and it’s probably based on their experience with what they see. Omega 3, hands down. You need omega 3. It makes no sense not to have it. I measure those levels. Everybody is ridiculously deficient. I think the dosage would be between five and 10,000. If somebody has a bleeding diathesis and they could bleed a lower amount, there is no reason to not take this on coumadin because that’s crazy. So I think omega 3.

                                         I think vitamin D, which is not a vitamin, it’s a hormone. It got promoted when Pluto got demoted from a planet. Vitamin D got promoted to a hormone. Vitamin D is really essential for the immune system. It’s really essential for the soft tissue and generally it’s going to be between two and 10,000, depending upon what you’re treating, International Units per day.

Dr. Weitz:                         Vitamin K2?

Dr O’Neil-Smith:               Vitamin K2. You can take that with it. It makes it easy. Now you just have two supplements. You’ve got omega. You’ve got D with K2. The third I would probably do is BPC because it’s easy, it’s affordable, it’s effective. Take a low dose. It’s going to keep you well. The fourth I might consider would be probably an NAD plus. That’s to keep-

Dr. Weitz:                         I’ve been using the NR, nicotinamide riboside.

Dr O’Neil-Smith:               It comes in many forms, but one way or another, get some NAD. It could be as an ATP fuel. It could be as NAD plus. There’s many different ways of getting it, and you’re familiar with that. The next product that I might use is probably a match with resveratrol versus curcumin/turmeric. So I think those are really, really beneficial. Curcumin and turmeric are similar. There are really good forms of curcumin.  Find a good form. Stick with that form. Go with that.  The next product, again resveratrol, you maybe can get that by I don’t know start with drinking two ounces of dark tart cherry juice a day a day instead of buying a supplement.

Dr. Weitz:                         Therapeutic dosage requires 26 bottles of red wine a day.

Dr O’Neil-Smith:               There are some good supplements out there for resveratrol as well.

Dr. Weitz:                         I definitely take every one of those. I’m on the same page with you. Plus tocotrienols, astaxanthin.

Dr O’Neil-Smith:               NAC.

Dr. Weitz:                         NAC. Acetyl-L-carnitine.

Dr O’Neil-Smith:               And then probiotics. I mean probiotics are a little tricky. I would say that everybody probably needs a probiotic with I don’t know 25 billion whatever it is. If they can find a probiotic with resistant starches, fantastic. Those are the prebiotic. The resistant starches are key. Those are more fibrous. They’re very good. You could take resistant starches alone. Phenomenal. So that’s really…

Dr. Weitz:                         As long as you don’t have SIBO.

Dr O’Neil-Smith:               Yeah you want to get your bowel moving before you do that for sure. You want to not be constipated when you do that. And then the things not to do, right, if you didn’t grow it, can’t pick it, don’t eat it. Really important. The longer the shelf life of the food, the shorter your shelf life. Really basic stuff.  Salt.  Get rid of sodium chloride.  We don’t have a sodium deficiency in our body but because the sodium is so high it makes our magnesium low relatively.  It makes our potassium low.  It makes our zinc low.  It makes many minerals low.  So absolutely really be cognizant of those processed foods. They’re full of salt.

                                                If you can figure out the foods that glutamate is in, or monosodium glutamate and where it’s hidden in foods, that’s really important. So if you look up MSG hidden sources or you look up Russell Blaylock, who is an MD, whose really just written some phenomenal books on that, on excitotoxins and how they kill your nervous systems. MSG being one of the major ones, glutamate … I think it’s really important to understand that.

                                                Those are some things to get rid of. Those are some things to add. I think that those are kind of universal. Those are if you come in and you want the number one in my practice, you just got it.

Dr. Weitz:                            That’s great. Awesome. Thank you, Dr. O’Neil-Smith. So how can patients and/or practitioners get a hold of you to find out about your programs and seeing you as a patient, etc?

Dr O’Neil-Smith:               So you know it’s really funny but in the last year, year-and-a-half, I decided to lead. Not to create followers, but to create leaders. I have developed a couple of things with another doc who we work quite closely together with because we have the same why. Simon Sinek says why are you doing this? Our why is to really leave a legacy of making a difference in medicine in a new way and being thought leaders.

                                                I have a program where I teach doctors and that program is a master class. We do that through Zoom. We finished our first master class, which was nine months. We’re going to shorten it to a six-month window. We basically meet on Zoom with a number of clinicians. You can look at treatwellness.com and see information for that. It’s called the Treat Wellness Peptide Master Class, but it’s principles about that. So that was amazing. The doctors … we just got their survey. It’s been amazing. The goal is to lead and create more leaders.  I want colleagues. I want a doctor like me in every state that you can send somebody to if you need help. I also know that in the trenches are the people that I work with, whether they’re the health coaches in my office, the PA in my office, whatever they do, psychologist in my office. Those people are probably more important for me. We teach those. We have a program that we’re developing through full scripts where we teach other than MD/DO, all about these things and how they can use them in their practice and how they can know when to refer and be on a team, and be leaders in their industry.

                                                Because we want to change brain health and we want to change gut health, and we want to avoid continuous injury. The other thing that I have is a website that’ll be published this week called Fire Em Up … Firrimupdoctors.com, and on that website we’ll have podcasts like you have that are designed to just be educational and direct to people like you, people like health coaches, people like really good body workers, athletic trainers, nutritionists, etc., who can be working with patients. It takes a village.  On there we have docuseries with experts, podcasts with experts, teaching on principles on medicine to try to avoid people from having a life span and not a health span. So firrimupdoctors.com. That’ll be out this week. You’ll see us doctors with their patients in the clinic giving an example of specific cases. You’ll hear experts like Dr. Fasano, Alessio Fasano from the Mass General who is a gut health expert and mucosal immunity. You’ll hear hormone experts. You’ll hear brain experts like Dr. Perlmutter. We’ll have all of these doctors on there.  Then we’ll also have … whenever we’re at a conference we’ll do a Facebook live. We’ve got Facebook live conferences in the past. We’re going to promote those as well just to educate. It’s free education. Come on. Learn about who you should go see and for what particular thing that is ailing you. So you don’t only treat the symptom of bloating or pain or headache. You treat the root cause. You get to the cause of that symptom and you make it go away more predictably. Maybe not for good because we can’t predict that, but maybe more predictably.

Dr. Weitz:                         That would be great. If you could email me those links, I’ll make sure to put them in the show notes.

Dr O’Neil-Smith:               That’d be good. Great. I will do that.

Dr. Weitz:                         Thank you, Doc.

Dr O’Neil-Smith:               You’re so welcome. Thank you, and thank you for the work that you do.