Lauren Bongiorno discusses Type I Diabetes with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

5:53   Some of the most important variables that we need to manipulate for type I diabetes are nutrition and exercise.  With respect to exercise, there is the type of exercise, the time of exercise, what your insulin sensitivity levels are, and what kind of food you have before exercise.  With nutrition, the combination of macros, timing of macros, and the timing of insulin are all important factors.  Also important are your relationship to food, your mindset to diabetes and your acceptance of it.  Your hormones, including the menstrual cycle, and cortisol are other factors that are probably more important for type I diabetics and all these factors have to be juggled at the same time. 

7:30  Monitoring glucose levels.  Lauren monitors her glucose with a continuous glucose monitor (CGM), the Dexcom, but this technology is not accessible to everyone, since it may not be covered by insurance and it is somewhat costly. Ideally every type I diabetic should have access to both a CGM and an insulin pump.  On the other hand, some people are perfectionist and they may obsess too much on getting their numbers perfect and using a CGM may drive them crazy, constantly living on their phones, watching the arrows and trying make decisions to control the numbers.  It’s also important to get to know your body’s patterns and to know what a higher or lower blood sugar feels like.

11:17  Maintaining blood sugar overnight.  Lauren does not feel that there is one way to help type I diabetics to maintain stable glucose levels throughout the night while sleeping. Some diabetics do well with a high carb, low fat approach, while others thrive with a keto style diet. Some do well eating some fat in the evening to keep blood sugar even, while others do better having a carb snack in the evening. 

 

 



Lauren Bongiorno is a health coach, a diabetes influencer, and the founder and CEO of Risely Health. Lauren has dealt with type I diabetes since she was 7 years old. She is challenging the current healthcare system and the world of diabetes management through her company’s innovative health coaching programs and online educational classes.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss and also athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111. Dr. Weitz is also available for video or phone consultations.



 

Podcast Transcript

Dr. Weitz:      Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates, and to learn more, check out my website, drweitz.com. Thanks for joining me and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Today. I’m excited to be talking about type 1 diabetes, which is not a topic we’ve spoken about very much on the Rational Wellness Podcast. We’ve had a number of conversations about type 2, but type 1 is a very important topic and type 1 diabetics need a lot of help from nutritional perspective that they often don’t get.

What is type 1 diabetes? Most of us in the functional medicine world see a lot more patients with type 2, and that’s because only about 5% of diabetics are type 1, but type 1 diabetes used to be known as juvenile diabetes, but it’s probably better described as insulin-dependent diabetes.  In this condition, the pancreas produces little or no insulin. Insulin is a hormone that signals the muscles to pull sugar from the bloodstream, to enter the cells used for energy. It’s generally understood that type 1 diabetes is an autoimmune origin, and while usually develops during childhood or adolescence, it can develop in adults. The cause of type 1 diabetes is controversial and we’re not going to go into all the possibilities, but there’s discussions about gluten and dairy and a bunch of other issues that may contribute to the causation of type 1 diabetes.

To lead the discussion this morning is Lauren Bongiorno. She is a health coach, a diabetes influencer, and the founder and CEO of Risely Health. Lauren has dealt with type 1 diabetes since she was seven years old. She is challenging the current healthcare system and the world of diabetes management through her company’s innovative health coaching programs and online educational classes. Lauren, thank you so much for joining us.

Lauren:           Thank you so much for having me. I’m looking forward to this discussion.

Dr. Weitz:       Great. Maybe you can start by telling us a little bit about your journey and when you just first discovered that you had type 1 diabetes.

Lauren:           Yeah, absolutely. It’s interesting, now, in our practice and in our health coaching company at Risely, we see people getting diagnosed with type 1 diabetes at 40 years old, 50 years old, 60 years old, but like you said earlier it is very more well-known that children get diagnosed. I was one of those children. I was …

Dr. Weitz:       Wait, by the way, why do you think more people are being diagnosed later with type 1?

Lauren:           Yeah, you know what? I think that in the past a lot of doctors have misdiagnosed adults as type 2. It just took a longer amount of time to get them the correct diagnosis, but COVID also, we saw a huge spike after and within the past two years of diagnosis after COVID and the stressors of either getting COVID and then having it afterwards, or just the life stressors with things changing in your routine and people dying in your life that maybe have potentially triggered it.

Dr. Weitz:       Interesting. There’ve been some discussion about viral triggers. You’re saying SARS-CoV-2 virus and/or possibly the vaccine may have triggered an autoimmune process that’s leading to type 1 diabetes?

Lauren:           Yeah. There’s more research coming out now about it. I think it’ll be something that over time, will have to be looked at, but there is definitely some kind of relation between it.

Dr. Weitz:       Interesting, interesting. When it gets diagnosed later in life, it can be confusing because there’s a type 1.5 diabetes, this latent onset, right? Diabetes that’s different than type 1.

Lauren:           Mm-hmm (affirmative). Exactly. Yeah. There’s many different types of diabetes. There’s more than type 1 and type 2.  I personally live with type 1, which is an autoimmune disease.  My body doesn’t produce insulin, which is basically the thing that helps take the sugar out of the bloodstream.  I was diagnosed at seven years old.  Your whole entire life from in that point is changed in the way that you’re living.  You hear from a very young age, if you don’t take care of yourself, hear all the terrible things that could happen to you.  As a child, you’re like, “Oh, that’s so far away, right?”  But it sneaks up on you.  I’m going on 22 years of living with it. I’ve been through many stages of living with my diabetes.  It’s way more complicated than just eat less carbs and exercise.

Dr. Weitz:       It must be pretty traumatic for a seven-year-old kid to suddenly have to start pricking your finger to measure your glucose levels and injecting insulin.

Lauren:           Yeah. I’d actually argue that it’s more challenging for the parents than it is for the child a lot of the time. I know that my parents and we also work with a lot of parents in our family coaching program at Risely, they went through the newborn stage already with their child or multiple children.  This is kind of that like second wave of having a newborn because you’re waking up multiple times in the night to check your child’s blood sugar. You’re constantly focusing on all these hyper decisions that need to be made that you shouldn’t have to think about as a parent, but you ultimately do when your child’s diagnosed.

Dr. Weitz:       What are some of the most important variables that we need to manipulate to help manage patients with type 1 diabetes?

Lauren:           Yeah. Like I alluded to earlier, many of what we, much of what we understand type 1 management to be is around nutrition and exercise. Just within those two categories, there is about 20 different factors that influence your blood sugars, right? There’s the type of exercise you’re doing. The time of exercise you’re doing, how long you’re exercising for, what your insulin sensitivity levels are, your resistance levels, where your starting number is at, what kind of food you have before it.  Then, with the nutrition, it’s the combination of macros, timing of macros, timing of insulin, right? All of these are different factors. That’s just one part of already what we know, but under the surface, there’s all these other levels. You can think of it as an iceberg, right? On the top of the water, you can see that most obvious things that you have to be looking at to manage your type 1 diabetes, but beneath the surface, you have things like relationship to food and your mindset to diabetes, how your acceptance level of it, right?  Your hormones, your background, cortisol levels, or for females, your whole entire 25, 26 to 34 day cycle that’s having, give or take, depending on your particular hormones but that impacts your blood sugars, right? There’s so many of these other factors where type 1 diabetes is not like type 2, where you can take Metformin, you can take a pill and it helps the majority of the symptoms. We’re very much juggling all these factors at any given time.

Dr. Weitz:      Interesting. How do you recommend monitoring the glucose? I’m assuming you probably recommend one of the continuous glucose monitors available today.

Lauren:           Yeah. They’re the two main leading glucose monitors are the FreeStyle Libre and the Dexcom G6. I believe the G7 just came out. This is for people with type 1 diabetes, the most popular, I wear, the Dexcom. The thing is that it’s not, the technology is not accessible to everybody. You always have the option to be finger pricking for you to see what your blood sugar is.  I wish, and it should be that these technologies and insulin pumps as well are available to everybody, but it’s just not the case, but it does make your life so much easier because you can just look down at your phone, in my case, on the Dexcom, see what the blood sugar is and make a decision based off of that.

Now, on the flip side of it, you have people who are highly perfectionist, who you’re never going to get your numbers perfect, and if you attach too much to it, it’s going to drive you crazy because if you’re constantly living on your phone, watching the arrows, trying to make the decisions, you’re not going to be living in the present moment.  I think it’s really important to balance that this is a long marathon and it’s not on a sprint and you have to develop sustainable habits with everything, with food, with nutrition, with mindset, all of it.

Dr. Weitz:      The worst thing you could do is get too stressed out over and have an increase in your cortisol levels, which will raise your blood sugar. Then, we also have to keep in mind that as high tech as these insulin, as these glucose monitors are, they’re not perfect.  For example, both of these monitors that you mentioned, the FreeStyle Libre and the Dexcom, they’re measuring interstitial fluid, which is not exactly the same as the glucose levels in a bloodstream. It’s close, but it’s not perfect.

Lauren:           Yeah. That’s a really good point. I think at the end of the day, what it comes down to is being able to know your body’s patterns and first without the technology, have a good relationship with what a higher blood sugar level feels like.  Right now, when people are getting diagnosed with type 1 diabetes, you are a lot of the time getting put on a CGM right away. For me, I was diagnosed at seven, I didn’t have a CGM for 15 years. I slept through the night, given my mom checked my blood sugar maybe once or twice in the middle of the night for the first few years, but there wasn’t that amount of data that we have today.  It was beneficial, in my opinion, because I now can look at my number and instead of just giving food for a low blood sugar that the CGM is saying, or giving insulin for a high that it’s saying, I can say, “You know what? That’s actually not the case. That’s not really what it is.” I can test my blood sugar on a finger prick, and then I can say, “See, that’s the right thing and I knew I was on the right track there.”

Dr. Weitz:       Yeah. Interesting. I just wanted to comment, one of the things that happens when you do podcasts is sometimes you have weird things happen with lights. I remember having one interview where the person I was interviewing had the light coming in through the tiny beads and you have shades that you use to block out the light on your window and there’s tiny holes and the light was coming out and going across his face. I see your [crosstalk 00:10:55].

Lauren:           Well, because my window, I’m backlit over here. You would not see me if I didn’t have a ring light over here.

Dr. Weitz:       I know. I have a ring light too, and sometimes it shines off of the frame on picture behind me. It’s all those things you have to deal with.

Lauren:           All of [crosstalk 00:11:14].

Dr. Weitz:      It’s interesting. Anyway, but you brought up something that people who don’t know about type 1 diabetes have no clue about and people with type 2 diabetes generally don’t have to worry about. I think this is a good time to talk about that is worrying about making sure that your blood sugar doesn’t drop too much during the night.  Normally, with type 2 diabetics, all we’re concerned about, or mostly what we’re concerned about is that fasting glucose in the morning, we don’t usually worry about problems with their glucose during the night, even though sometimes they can have problems there too, but for type 1 diabetics, it’s really crucial that their glucose, in particular, doesn’t drop too low during the night.  Do you have a strategy for trying to keep the glucose from dropping too low during the night? And this is sort of starting to our discussion of diet. I did have one discussion with another guy who was a health coach who talked about eating some healthy fat in the evening before bed. He actually has some product with a bunch of nuts and things like that in it.  What do you think about the best strategy to keep the blood glucose fairly even during sleep?

Lauren:           Yeah. Look, I’m here to change the narrative, I think, around a lot of what we’ve heard that is the best for anything, right? What’s the best strategy or way to eat for this or for that? There really is no best way and I’m not just saying that, right? You could have somebody who thrives on the keto diet, somebody who thrives on high carb, low fat, who thrives on this, vegan, whatever it is, but the truth of the matter is, you have to find what works best for your pattern in terms of what’s sustainable, but also for your blood sugars.  There is no one size fits all. It’s actually the main issue with the healthcare system is that they view too much all type 1s as a here’s what’s were going to work for all of you and that’s just not the case. You have one guy, I don’t know if he was talking about type 2 or type 1 or whatever.

Dr. Weitz:       He was talking about type 1. Yeah.

Lauren:           type 1, okay. You have somebody who’s saying that increased fats before bedtime are going to help you sustain without having a low, I can give you 20, 25 case examples in the next 20 minutes of people who would not benefit from that, right?  Because increased fats in their diet are going to actually sustain a higher blood sugar number over bed. It’s not exactly what is one size fits all, but hey, what happens to my blood sugars overnight? If it’s they’re going too high, they’re going too low, what needs to happen beforehand?  I can give you a personal example for me. If I had fats before bedtime, my blood sugars would be running high because that fat acts like a buffer and help and creates a little bit of resistance to my insulin, my basal insulin that’s coming overnight. For me, it’s actually more beneficial to have a carb snack if I want something for dessert. Let’s say a bowl of berries or an apple with maybe just a little bit of peanut butter, something like that because I can then give insulin for it. I know how it’s going to, what it’s going to do with my blood sugars in those two hours and there’s not going to be a prolonged effect on my blood sugars in that two to eight-hour span, which happens when you add some facts in.

Now, it depends on the amount of fats, the quality of the fats, all these different factors, but all to say in the end that it’s like, look at what’s happening to your blood sugars overnight and understand what certain foods do to your specific blood sugars and then make informed decisions based off of that.

Dr. Weitz:       Right, but I wanted to point out that, where is type 2 diabetics until a point at which they get to having to take insulin, the big issue is their glucose being too high and type 1 diabetics have to worry, not only about it going too high, but also about it going too low. I think the idea of using fat was to keep it from dropping during the evening.

Lauren:           Right, and I think that where the misconception is, and really understanding is so with type 1 diabetes, we have insulin that goes in our body 24/7 in all these different rates, right? Especially if you’re on an insulin pump, you have different insulin, every two hours it can be for different rates. Technically, if I didn’t eat for 24 hours, my numbers based on those insulin rates should actually stay stable and should not drop.  Now, if you’re on shots, which might have been the case for that past episode guest that you had on, that could be possibly a, well, I can’t change my insulin rates overnight time, so I have to use fats because my natural tendency is to drop. In his case, of his bio-individual body, those fats could be helpful for him.

Dr. Weitz:       What percentage of type 1 diabetics are on insulin pumps?

Lauren:           It really comes down to the accessibility issue that I said earlier. I would say that, I would have to guess a lot of people who have the option of doing, being on pump therapy or on CGMs, they choose to do that, I think it’s a larger percentage and the people who have the option based on insurance, and then say, I don’t want to go on. I just would rather be on shots. I don’t know the exact percentage, but I don’t know if it’s 50/50, I’m not really sure.

Dr. Weitz:       It’s based on cost and insurance coverage.

Lauren:           Cost insurance coverage and then of course, preference, right? A lot of people, there’s three leading pump companies. Two of them have wires, one of them, doesn’t. The Omnipod and that’s the one I’m on. If somebody doesn’t want to be on a pump and have something extra on their body, that’s another reason why they might not choose it.

 



Dr. Weitz:            I’ve really been enjoying this discussion, but I’d like to take a minute to tell you about a new product that I’m very excited about. I’d like to tell you about a new wearable called the Apollo. This is a device that can be worn on the wrist or the ankle, and it uses vibrations to stimulate your parasympathetic nervous system. This device has amazing benefits in terms of getting you out of that stressed out sympathetic nervous system and stimulating the parasympathetic nervous system. It has a number of different functions, especially helping you to relax, to focus, to concentrate, get into a deeper meditative state, even to help you sleep, and there’s even a mode to help you wake up. This all occurs through the scientific use of subtle vibrations.

                                For those of you who might be interested in getting the Apollo for yourself to help you reset your nervous system, go to apolloneuro.com and use the affiliate code, Weitz10. That’s my last name, WEITZ10. Now, back to the discussion.

 



Dr. Weitz:      Let’s talk about diet. You already set up the discussion by saying that you’re here to prove that or make everybody understand that there’s no one best diet for type 1 diabetics, but given that, how should we figure out what to eat if you’re a type 1 diabetic, or how should we decide what to recommend if you’re coaching somebody who’s a type 1 diabetic?

Lauren:           Yeah. It’s a great question because we can’t just look at it and say, “Oh, well you have type 1 diabetes. Just eat whatever you want and don’t worry about the blood sugar strategy. Don’t worry about the insulin strategy, right?” There has to be some thought process to it.  Kind of my rules in how I like to think about this is, first of all, what I love about coaching is my job is not to replace a dietician, a nutritionist, a doctor, a certified diabetes educator, there is a place for all of us and where the coach fits in is really by putting the client and the type 1 diabetic in the driver’s seat and saying, “You know what? I have all this information coming at me, but ultimately I have to decide kind of what works best for me.” What you’ll see a lot of is people who look outwards to follow specific diets, and then they do it and it’s not sustainable.  I think the number one rule is find something that’s sustainable for you. Is it sustainable for you to never eat bread again? Probably not, right? Are you going to set yourself up for failure if you say that and then feel like, “Oh shoot, I can’t be successful,” and kind of go through that restrict binge cycle. That’s not good, right? It has to be sustainable.  The second thing is obvious, it’s what’s good for everybody, which is lead with whole foods, right? Lead with real whole foods, less processed ingredients, less inflammatory foods for people who have celiac, obviously less gluten. I think all type 1s, there’s been a lot of research on the benefits of drastically reducing dairy. That’s the case for a lot of people. What benefits people who are type 1 and not type 1. I would say that’s the second piece.  Then, the third piece is knowing that there’s an emotional component to food, right? That there’s a pleasure element to food. It doesn’t mean we’re having pizza every day, but to find a place for the foods that you love, that are part of your culture, part of your family, part of your enjoyment, and figuring out a way to have those foods and also be able to have the insulin strategies to meet it so that you don’t have to compromise blood sugars.

Dr. Weitz:       Of course, when you say we’re trying to eat foods that are going to lower inflammation, there’s many, many different thoughts about that. There’s a thought and some data to show that maybe animal products and saturated fats are going to raise inflammation.  There’s thoughts and some data to show that lots of fruits and vegetables, anything with seeds, anything with lectins, grains, legumes, that’s going to cause inflammation. Foods that you have sensitivities to, are going to cause inflammation. I’m used to, I’m not sure it’s so easy to know what is going to reduce inflammation.

Lauren:           Right. I think that you’re exactly right. There’s controversial opinions on what is the best diet. You can find books written on lectins being terrible and having certain fruits and vegetables that have those and being inflammatory and exactly like what you said about opposing theories.  I think ultimately, what it comes down to, is how does your body feel when you have those things? I know that when I have dairy, the next morning I wake up, my hands are literally swollen. I know that I’m never going to fully cut out dairy, but it’s not beneficial for my body. I’m puffy, I’m sluggish. I don’t like the way it makes me feel. It doesn’t help with my blood sugars. That’s enough data for me to make an informed decision versus having to go out and read all the research studies on if dairy is good or bad and then decide based on that. It’s really combining the inner wisdom with the outer wisdom.

Dr. Weitz:      Still when you’re working with, by the way, you mentioned how a health coach is different than a dietician versus a doctor, I’m a little confused about that. What exactly is the difference between a health coach and a dietician? Don’t they both put people on recommended foods and, I’m a little confused. What is the difference?

Lauren:           Yeah, it’s a great question. I think that the coaching industry in general, now there is, I’m a nationally board certified health coach and we are the National Board is under the medical board of examiners. This is something that is new in the past few years and even when I first became a coach, I’m coaching people in 2015 was very like, what is health coaching, right?  At the root, health coaching helps people prioritize themselves and get unstuck by helping them develop the tools and the strategies to become aware of what their blocks are, what their patterns are so that they can move towards the vision that they have for themselves. It ultimately pushes them in the, it puts them in the driver’s seat and helps them tackle behavior change more than just giving them a plan to follow.  Where when you see a dietician or a nutritionist, they’re going to say, “Okay, here’s how to balance your meal at lunchtime and here’s the plan. This is your goals to have eat exactly this, do exactly that.” We’re more of the mindset, behavior change, helping you identify your patterns of what’s working and what’s not.

Dr. Weitz:       Interesting. Okay. Let’s get back to, what are we going to tell this type 1 diabetic that’s coming to see you today, what they should be eating for breakfast?

Lauren:           Yeah. If they were to come to me and say, “Hey, my blood sugars are high after breakfast. What should I be eating?” My role is to not tell them, this is what you should be eating because then that’s saying that I know their body better than they do. Instead-

Dr. Weitz:       Well, I know my body works great when I eat frosted flakes and I pour some extra sugar on it.

Lauren:           Well, then they [inaudible 00:24:31], right. Then, they wouldn’t come to me and say that there’s a problem with it. Then, there’s no reason that they’re here. They’re here and while we’re working with them is because they’re saying, “Hey, this isn’t working what I’m doing. I need to figure out what is.”  Likely, the conversation goes, “I’m having Frosted flakes in the morning. I don’t know why my blood sugars are going high after.” Then, I can say, “All right, well tell me a time that you did have stable blood sugars after breakfast. What did you eat that was different?” “Oh, you know what? I had eggs and toast.” “Oh, interesting. You had carbs, but you also had some fat and protein. What does that tell you?” “Oh, it tells me maybe I had to have to add some fat and protein to my frosted flakes.” “Okay. Would you like to try that?” “Yes, I would.” “Well, let’s get curious and let’s see what happens after you do.” Right? That’s how the conversation starts and where it goes from there.

Dr. Weitz:       What would you recommend to eat for breakfast, if you’re a type 1 diabetic?

Lauren:           It’s something that’s pretty much, I mean, like I said, it’s not as specific-

Dr. Weitz:       Let’s say I came to you and I said, “Look, I want to be perfect. I’m a type 1 diabetic. I want to live a long life, which I’ll eat anything. I don’t care. If you tell me to eat dried hamsters with strawberries on it, that’s what I’ll eat.”

Lauren:           It’s not my role to tell them what to eat.

Dr. Weitz:       Okay.

Lauren:           I’ll stand by that, but what I will tell you is that I can give you one client that eats 70 carbs for breakfast of fruit and has perfect blood sugars after because they’re on a high carb, low fat diet, just a lot of fresh fruits, fresh vegetables. Then, I can have somebody who has stable numbers after breakfast and has eggs with two pieces of avocado, toast and have stable numbers.  It’s not about the food, it’s about that person’s body, how they metabolize it, how their insulin sensitivity levels and weigh more than just what the food that they’re eating is.

Dr. Weitz:       I do think that there’s a trend, especially in a functional medicine world, that diabetics, whether type 1 or type 2, should both be on a lower carb approach, but from reading some of the blog posts on your website, I think that’s something that you don’t agree with.

Lauren:           Yeah. I think that there’s people who, for sure, thrive on a lower carb diet. It’s definitely easier, right? When you take carbs out of the equation, it’s a lot easier to not see that initial blood sugar spike, but what you see and this isn’t my opinion, this is research and science fact, when you have a higher fat diet, there is a higher A1c correlated to that and a lower percent time in range due to insulin resistance.  There’s plenty of research that shows when you have a higher fat diet and you’re eating carbs at the same time, you’re going to have a little bit more elevated, than, if you’re eating even kind of moderate levels of everything, a little bit more moderation, there’s also tons of research that shows when people have a high carb diet and I’m talking 400, 500 carbs per day and a super low fat under 20% diet, they can have great A1c’s too. You can find the support, the research to support either one.

Dr. Weitz:       Yeah. I’ve talked to other coaches. I interviewed Cyrus Khambatta and Robby Barbaro, do you know them?

Lauren:           Yes. I know both of them.

Dr. Weitz:       They have Mastering Diabetes and they basically told me the same thing. I personally have not ever noticed that. Quite patients that I work with who have elevated hemoglobin A1c, I’ve never seen anybody who followed a low fat, high carb diet lower their hemoglobin A1c.

Lauren:           Yeah. They’re master in diabetes, Cyrus and Robby are great examples of that, where they’re saying, “Hey, we’re going to show you a different way to do it.” I have ate their diet before, and it’s not sustainable in my opinion, but there are plenty of people who it works for them and you can’t fight the results, right? They speak for themselves. You can’t fight the results of somebody lowering it by removing carbs. You can’t fight the results of people lowering it by increasing carbs and having super, super, super low levels of fat.  That, to me, you’re taking out oil, you’re taking out a lot of those that macro that helps other things of the body, like your skin and your hair and your nails and all that type of research, right? There’s controversy in so many different areas, but the point is, is that if it works for somebody, we can’t knock it, right? It’s a possibility.

Dr. Weitz:       I guess one of the concepts is that increased levels of either fats or saturated fats, or I have even heard people claim that animal proteins increase, decrease insulin sensitivity.

Lauren:           Mm-hmm (affirmative). Yeah.

Dr. Weitz:       Which of those? Do you think all of those or do you think it’s just saturated fats or [inaudible 00:29:19]?

Lauren:           Yeah, for sure. For sure, what we can see and we have let’s say 800 people that apply for our coaching programs per year. We have a lot of data in terms of type 1 diabetics and food and what works and what doesn’t for the majority of people. What we can tell is the higher the dairy and the animal fats, I don’t know, specifically saturated, [crosstalk 00:29:40]…

Dr. Weitz:      Yeah, and animal fats. Okay.

Lauren:           … animal fats, it’s contributing to the higher levels of insulin resistance. Now-

Dr. Weitz:      You’re measuring that by hemoglobin A1c?

Lauren:           Yeah, by hemoglobin A1c and also time and range. Time and range, I think, is even a better indicator than A1c.

Dr. Weitz:      Okay. What is time and range?

Lauren:           When you wear a CGM, oftentimes the doctor will say, your time and range, we’ll set your goal between 80 and 180. It’s how much, what percentage of the time are you staying between those numbers? You want that number to be higher.

Dr. Weitz:      Is that what the range is, 80 to 180?

Lauren:           Yeah. Pretty much. You can change it. [crosstalk 00:30:21].

Dr. Weitz:      180 sounds kind of high, huh?

Lauren:           For a type 1 diabetic, no. It’s not because it’s very unrealistic to say that for a type 1 where your body literally doesn’t produce any insulin and you’re in charge of monitoring every single thing, the expectations right, would drive people crazy if it was any lower than that.

Dr. Weitz:      Wow. Okay. Interesting. What about coffee for type 1 diabetics?

Lauren:           Interesting question. In the morning time on an empty stomach, you’re going to see most likely, depending on somebody’s tolerance for caffeine, how much they’re drinking it, frequency, all of that, you’re going to see blood sugar rise from coffee, even if there’s no sugar and there’s no cream, anything in it. That’s something that happens to me as well. I actually have to give insulin for black coffee.

Lauren:           Now, when you make a small shift of eating something before you have black coffee, a lot of people will see a decrease in their blood sugar response due to just that little switch.

Dr. Weitz:      Interesting. I wonder what about, have you looked at people who have more of a response from coffee or less of a response? I know there’s certain genes that correlate with that. Is it more because people get a bigger response from coffee, get more of an increase in adrenaline cortisol and that’s what spikes the sugar?

Lauren:           Yeah. In my opinion, what I have seen and what I’m seeing is that your cortisol levels are higher in the morning time period, right? They taper off [crosstalk 00:31:54].

Dr. Weitz:      They’re supposed to be, right.

Lauren:           Yeah. They’re supposed to be, exactly. If you’re adding caffeine on top of it when you’re waking up and you’re already a little bit dehydrated and you’re not, let’s say, drinking water and you don’t have any food in your system, there’s just a higher blood sugar response.  Sometimes I say, you don’t have to know the why, you just have to know the patterns. Whether that has to do with their, how frequently they’re drinking it, if it’s caffeinated, decaffeinated, all these different factors, if it’s happening, there likely has to be insulin being given for it.

Dr. Weitz:      For type 1 diabetics, are you recommending small frequent meals? Are you recommending any periods of time where they don’t eat as you know, one of these strategies for longevity these days is intermittent fasting.

Lauren:           Yeah. In our years of working with both men and women, we’ve seen more men benefit from an intermittent fasting than women have. I think it has a lot to do with relationship with food, with hormones, depending on where they are, in terms of what age they are. I think it can be beneficial for certain people and depending on what their goal is.



Dr. Weitz:                            I’d like to interrupt this fascinating discussion we’re having for another few minutes to tell you about another really exciting product that has changed my life and the life of my family, especially as it pertains to getting good quality sleep. It’s something called the chiliPAD, C-H-I-L-I-P-A-D. It can be found at the website chilisleep.com, which is C-H-I-L-I-S-L-E-E-P dot com.

So, this product involves a water-cooled mattress pad that goes underneath your sheets and helps you maintain a constant temperature at night. If you’ve ever gotten woken up because temperature has changed, typically gets warmer, this product will maintain your body at a very even temperature, and it tends to promote uninterrupted quality deep and REM sleep, which is super important for healing and for overall health.

If you go to chilisleep.com and you use the affiliate code, Weitz20, that’s my last name, W-E-I-T-Z, 20. You’ll get 20% off a chiliPAD. So, check it out and let’s get back to this discussion.



 

Dr. Weitz:      What about alcohol, like a glass of wine? How does that affect diabetics?

Lauren:           Yeah. Interestingly enough, let me ask you, do you think that alcohol raises or drops blood sugars over, let’s say a six-hour period?

Dr. Weitz:      I’ve done a little research into this recently and it’s common for people to say alcohol gets converted into sugar, but the reality is alcohol gets processed by the liver and it’s a long route until it gets converted into sugar. A number of studies show that alcohol reduces glucose response with the meal.

Lauren:           Yes, exactly. I was so curious if you knew that if you were familiar with that because a lot of people think exactly like you said, that it just raises blood sugar. Now, there’s certain types of alcohol, that if it has sugar in it, and you’re adding creamery [crosstalk 00:35:32].

Dr. Weitz:       Like a mixed drink that has added liqueur or something like that.

Lauren:           Right, right, right. Exactly. Your blood sugar is going to rise from it likely, but over time, over the next couple of hours, they’re exactly what you said is happening with the liver, you’re likely to see low blood sugar. It’s why doctors are very, very careful of telling kids before they’re going to college if they have type 1 diabetes, if you’re drinking, you have to have a plan in place for definitely eating before you’re drinking, and also being mindful of your numbers overnight, because that can become a really dangerous situation.

Dr. Weitz:       If the glucose drops too low while they’re sleeping.

Lauren:           Yeah. It’s a big source of type 1 deaths, where-

Dr. Weitz:       What do you think is the critical level that should not drop below?

Lauren:           I mean, I’ve seen more-

Dr. Weitz:       Sixty?

Lauren:           No, no, no, no. No, no, no. I mean, of course, yeah. Technically on paper, it shouldn’t drop below, let’s say 75, but I’ve woken up in the middle of the night with numbers in my 21 years of living with diabetes, I’ve woken up at 35, right? It’s not that it’s, the threshold is a little bit lower than 35 before you’re in kind of a danger zone, but yeah, you don’t want to, the goal is to not get anywhere near there.

Dr. Weitz:       Okay. Let’s discuss exercise for type 1 diabetics.

Lauren:           Okay.

Dr. Weitz:       Generally speaking, when I’ve worked with type 1 diabetics, recommended that the most important thing is to do approximately the same amount and the same intensity of exercise every day, if possible.

Lauren:           That consistency?

Dr. Weitz:       Right.

Lauren:           Yeah. I think, type 1 thrive in routine. We thrive with consistency, with everything across the board, from workouts to sleep patterns, to nutrition, but is it realistic? Maybe not always, but as close as you can, especially I think for exercise, the more consistent you are with your exercise, the more you’re going to know what your body’s pattern is.  It also goes to say, if you want to do a workout on Monday and a yoga class on Tuesday and a 5k run on Wednesday, it doesn’t mean it can’t be done, right? It’s just, you have to know what your body’s patterns are for that and you might need insulin before one of them. You may need 30 carbs with a snack before another one, just based on the anaerobic versus aerobic, whatever type of workout you’re doing because they have different blood sugar responses.

Dr. Weitz:       In general, maybe you could address that. What about the blood sugar response in the average type 1 diabetic with resistance exercise, with high intensity training, with longer distance cardiovascular training?

Lauren:           Yeah, that’s a great question. Generally speaking, exercise, that’s very start and stop like if you’re sprinting or if you’re doing heavy weight lifting, those are going to be things that are going to more likely increase your blood sugar than to drop it.  Things like a steady state run or a, let’s say swimming or playing soccer in a soccer field, that’s probably a combination of anaerobic and aerobic, but more of that where you have your heart rate at a lower rate, but for a longer period of time, you’re going to see more of a steady drop but it also depends on how much insulin you have on board, right? That’s a key factor as well, but that’s generally what you’ll see for the patterns there.

Dr. Weitz:       It’s not unusual for say somebody doing an hour workout of resistance training to see their blood sugar go up immediately after the workout?

Lauren:           Yeah, exactly, but knowing that, how can you get ahead of that? I’ll give you my personal experience, right? Everybody listening, if you’re type 1, don’t do this for your body, because this is my specific pattern, but when I do weightlifting in the morning time, I will give myself insulin beforehand because I know that my blood sugar is going to go up. Normally, if I didn’t do that, my blood sugar would rise, but maybe if I do that, my blood sugar is actually not going to go up because I was able to counteract it.

Dr. Weitz:       Right. Now, my understanding of this, this is another thing I read up a little bit about recently is that that’s because you’ve used up the glucose in your muscles and now your muscles are sucking up glucose, so the body’s trying to produce some more glucose to give it to the muscles. Maybe you don’t want to take insulin then and decrease that. Maybe that’s just a normal response of the muscles and it’ll settle down in a little bit.

Lauren:           Right. For me, my main priority is not going high because I don’t want to have to go high afterwards and then go into a breakfast meal where I’m already starting off high, then I’m going to go higher. You don’t feel good. You feel more lethargic. I cannot perform in the gym as well as if I’m high, than if I’m in range. For me, my priority is always having that lower blood sugar and keeping it stable.

Dr. Weitz:       You use an insulin pump?

Lauren:           Yes. I use the Omnipod insulin pump to administer insulin. Correct.

Dr. Weitz:       Does that administer the same type of insulin all day? Okay.

Lauren:           Yeah. There’s this background drip that’s called basal insulin, that’s for 24 hours giving me different rates of insulin based on what I set it to. At, let’s say 12:00 a.m., it can be giving me 0.4 where at 3:00 a.m., it’s giving me 0.55, and then I give insulin that is also for giving corrections to correct a high blood sugar number and to also give insulin before food.

Dr. Weitz:       Okay. Now, there’s another strategy where people will use a longer-acting insulin at certain times and a shorter-acting insulin at other times?

Lauren:           Yeah. That’s if you’re on a, if you use shots and you’re not on a [inaudible 00:41:28], so you have your long-acting, your Lantus, your placebo, whatever it is and then you have your fast-acting, let’s say Humalog. They have different release times. For the long-acting insulin, you’re giving it either once in the morning or a night, or you’re giving it a split dose of it. Then, you’re just giving the fast-acting every time you eat. It’s just a different strategy of how you’re administering it.

Dr. Weitz:       Have you found any nutritional supplements to be helpful for managing type 1 diabetics?

Lauren:           I don’t know if I can directly speak to direct correlations, but for me, and for everybody, sleep is really, really, really important in terms of your blood sugars the next day, in terms of curbing your sugar cravings and carb cravings the next day, and sleep is a priority. I take magnesium sometimes before bed and that helps my sleep. It almost like, that’s one that I can say for myself indirectly has helped my blood sugar control.

Dr. Weitz:       What type of magnesium do you take and what dosage?

Lauren:           Oh, goodness. Now, you’re testing me.

Dr. Weitz:       No. No. I mean, you know people-

Lauren:           It has a purple top.

Dr. Weitz:       No. I’m not trying to put you on the spot.

Lauren:           No, it’s okay.

Dr. Weitz:       It’s just, you know.

Lauren:           I would say, I don’t, maybe you can tell me what, I can see the bottle, it’s G-Y, G-Y-L.

Dr. Weitz:       Glycinate, mag glycinate.

Lauren:           Glycinate. Yes. I take and that is the one that I have. I believe it’s a thousand milligrams.

Dr. Weitz:       No, it’s a hundred.

Lauren:           No? A hundred milligrams? All right.

Dr. Weitz:       Okay.

Lauren:           I was one zero off.

Dr. Weitz:       Unless you’re taking 10 of them. Any other nutritional supplements? What about berberine? What about cinnamon? What about lipoic acid? What about other nutritional supplements that are known to help with insulin sensitivity or managing glucose?

Lauren:           Yeah, I think that those are really popular for more of like type 2. You can see more direct correlations with that. type 1, because of the nature and it’s just different. There’s not anything that I can say that is directly correlating to lower blood sugars or that at least I know of or I have seen and I can speak to.

Dr. Weitz:       Now, what about any new nutritional supplements that can decrease your risk of chronic diseases? We know that patients with type 1 diabetes may have an increased risk of chronic diseases like heart disease?

Lauren:           Yeah, absolutely. There’s a lot of comorbidities that happen.

Dr. Weitz:       I’m thinking of things like fish oil, vitamin E.

Lauren:           Yeah. To be honest, this sounds even more of your zone of genius or a dietician, or like you could probably speak to this way better than I can, but I would say the biggest thing is understanding what your deficiencies are and advocating, because you’re most likely seeing your endocrinologist and they might not be looking, doing a full blood panel workup, things like that. It depends on what diet you have. I’m a pescatarian.

Dr. Weitz:       Yeah. Your endocrinologist is not testing you for nutrient status. I can tell you that.

Lauren:           Yeah. Exactly. Exactly. I’ve been a pescatarian for 11 years now. For me, there are certain supplements like B12 that I take that overall health, going to be more helpful and yeah, I think it’s individual.

Dr. Weitz:       Okay. That’s great. I think that’s a wrap for today. Thanks for sharing some useful information, helpful information for us. How can listeners, viewers find out more about your programs and get ahold of you? I understand you have some courses, both for laypersons and for practitioners, is that right?

Lauren:           Yeah. We worked primarily with people that have type 1 diabetes and also families of children that have diabetes. We have coaching programs and courses and ton of free resources. You can connect with me on my Instagram, which is just my name underscore in between the first and last name. Lauren_Bongiorno or find Risley Health on Instagram, R-I-S-E-L-Y health.com also is the website. We’re everywhere. You can pretty much find us, but if you came from this podcast, definitely shoot me a note and I’d love to connect with you.

Dr. Weitz:      Okay. That’d be great. Thank you, Lauren.

Lauren:           Thank you so much.

 


 

Dr. Weitz:      Thank you for making it all the way through this episode of the Rational Wellness Podcast. If you enjoyed this podcast, please go to Apple podcast and give us a five star ratings and review. That way, more people will be able to find this Rational Wellness Podcast when they’re searching for health podcasts.  I wanted to let everybody know that I do now have a few openings for new nutritional consultations for patients at my Santa Monica White Sports Chiropractic and Nutrition Clinic. If you’re interested, please call my office (310)395-3111, and sign up for one of the few remaining slots for a comprehensive nutritional consultation with Dr. Ben Weitz. Thank you and see you next week.

 

Dr. Christopher Shade discusses How to Reverse Biological Aging with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

3:05  Dr. Shade said that his chronological age is 53, but his biological age is younger. This is now measured by looking at methylation patterns on CPG islands in your DNA. This is through epigenetic clocks, such as the Horvath clock, as found in the Tru-Age test from Tru-Diagnostics.  [Turning Back Time with Epigenetic Clocks.]  The clocks have been trained or correlated with IQ, grip strength, balance, facial aging, etc.  If you are aging at a rapid rate, if you have a faster loss of function, then your biological age might be 70 when you’re 53, or if the pace of your aging is slow, then your biological age might be 43.  Our goal is to reduce our biological age to extend our health span.

6:35  Dr. Shade and Quicksilver Scientific have conducted a study using their supplements for three months and measuring their biological clock using TruDiagnostic’s TruAge test and the preliminary results look very good.  They saw improvement in the Horvath clock and in the pace of aging.  They beat the results of a two month caloric restriction trial.  They also saw positive epigenetic changes in certain white blood cells–monocytes and natural killer cells. The first month was detox with support for Nrf2 and AMPK activity (70% Nrf2/30% AMPK).  Second month, they shifted to 70% AMPK, 30% Nrf2, and a lot NAD+ and membrane building and sirtuin activation.   So clear things out, detox, then build up metabolic strength. Then the last month, we kept going on that mitochondrial metabolic strength, and the results were very positive.  According to Chris, “you start with AMPK phosphorylation with this PGC1A promoter for mitochondrial biogenesis, but then you have to deacetylate it with sirtuins, which means you have to have enough NAD+ to do that, and then you get full activation mitochondrial biogenesis, which makes more mitochondria per cell.”

11:14  AMPK, Nrf2.  How to slow the aging process should start with AMPK activation and this often goes hand in hand with Nrf2. Nrf2 is a master switch for chemo protection and when it’s upregulated, it’s called a nuclear transcription factor which means that it’s outside the nucleus and something triggers it to go into the nucleus.  Nrf2 is part of the chemo protection family, which includes antioxidants, detoxification, protein regulation, getting rid of unfolded proteins, fixing damaged proteins, and this is all cleanup stuff.  For example, to get rid of heavy metals, you need to raise nrf2 to bring up the glutathione genes and get rid of toxins like heavy metals.  AMPK can be triggered by fasting, carb restriction, exercise, and various nutraceuticals and pharmaceuticals such as metformin, berberine, resveratrol, and quercetin.  Fasting and carb restriction triggers you to mobilize and efficiently use your own stored energy resources, like glycogen, old proteins, and stored fat.  You use old proteins through autophagy.  You can increase glucose transporters, and lower insulin resistance/increase insulin sensitivity.  You are also going to mobilize stored fat and turn it into ketones for energy.  You can burn the fat out of fatty liver, which is called lipophagy.  If you take old, damaged mitochondria, and recycle them, this is mitophagy.  If you use old golgi apparatus and old endoplasmic reticulum, this is endoreticulophagy.  It’s the inner detoxification for your broken inner parts. So Nrf2 is more taking away environmental toxins and AMPK is more clearing out your own accumulations of waste, and that also includes unfolded proteins.  When you are always building proteins, sometimes you don’t make them right all the time, and you store the ones made improperly in vacuoles.  Eventually, if you don’t get rid of them, then your cells fill up with garbage.  So Nrf2 is an environmental cleanup and AMPK is a biological cleanup, and this raises yourself up to a higher metabolic efficiency. 

16:30  This autophagy happens because the body senses there are not enough amino acids to make up the proteins the body needs. There is also a switch that is engaged with this, called mTOR, the mammalian target of rapamycin.  Rapamycin was the first cancer drug that might be good for you because it blocks mTOR.  mTOR has a forward direction that is pro-growth and anabolic and then it is blocked and it causes you to go inward and recycle your own amino acids and burn your fat. If you are in growth mode all the time, you’re prone to cardiovascular disease and cancer.  Insulin and branch chain amino acids drive the pro-growth signals, while keto and intermittent fasting and the nutrients in the AMPK Charge product that Quicksilver produces and metformin all drive AMPK.

20:02  Uric acid.  There is a primal switch when your ATP (cellular energy) gets low, you can either go down the AMPK route or the AMPD route.  AMPK goes in and mobilizes resources, cleans up, and gives you insulin sensitivity, while AMPD does the opposite. AMPD increases fat storage, it further breaks down ATP. You burn off the AMP into xanthene, and then xanthene oxidase turns into uric acid.  Uric acid comes back around and blocks AMPK and keeps you stuck on the AMPD pathway. This AMPD pathway generates more uric acid, which creates creating mitochondrial stress and free radical damage inside the mitochondria, and it’s heavily associated with cardiovascular disease and early onset dementia.  If you are eating high fat but not restricting carbs enough, then you might need more polyphenols, more vegetables, you might not be eating enough vegetables, you might be eating too much salt, having too much alcohol, or not drinking enough water. 

22:40  Does promoting AMPK reduce cancer risk or protect cancer cells?  The reality is that while promoting AMPK and the other longevity pathways can prevent cancer, if cancer is present, they can also protect cancer cells.  But this is no reason not to promote the longevity pathways.

25:21  AMPK.  The best ways to stimulate AMPK is through intermittent fasting and also by working out fasted.  Almost every plant chemical has AMPK activation activity, including adaptogens and spices. The really strong ones include Berberine, Resveratrol and Quercetin.  Quercetin is so multifaceted because it stimulates AMPK, Nrf2, and sirtuins and is also a senolytic.  Milk thistle is both a AMPK and a sirtuin activator of the liver.  Many of the products that have AMPK activity also stimulate the sirtuins.  Ben Greenfield says that HIT training is the best way to activate AMPK with alternating periods for 30 seconds of all out training alternated with periods of rest. Morning is naturally more AMPK than night is. You have already fasted over night and there tends to be more autophagy in the morning and more rebuilding at night while sleeping.

29:35  NAD+.  NAD+ is a signaling molecule that’s present in the body for energy production, cellular energy, and for DNA repair.  At it’s most basic level, it’s going back and forth between NAD+, the oxidized form, and NADH, the reduced form. NAD+ is taking the electrons from your carbs, becoming NADH and going into the electron transport chain and dropping the electrons into the high energy electron transport chain and leaving the proton there. That’s eventually going to be pumped across the membrane, form that proton gradient, and come back through ATP synthase, and drive ATP formation.  So it’s shuttling energy from the sun, which is what built your carbs and your lipids, and bringing it in to make ATP.  NAD+ is also a cofactor in sirtuins, which are deacetylases. Acetyl groups are turning on or off different proteins.  To turn on the good anti-aging things, you deacetylate them, and turn on the bad anti-aging things, you acetylate them. But why would you want to acetylate the bad anti-aging things?  It’s to stop cancer growth.  While substances like resveratrol and pterostilbene and quercetin are sirtuin activators, NAD is the initial activator and it fits right into this hole in the sirtuin and activates it. NAD is also essential for gene repair. As we age, we’re always having assaults on our genes from getting exposed to toxins and radiation, etc.  PARPs go in to fix the genes, but they use the energy of NAD in this repair.  There’s also CD38, which also known as cyclic ADP ribose hydrolase, which seals up tight junctions when you get leaky gut or leaky brain or leaky liver, and this sucks in NAD as well.  NAD is doing all these things in every organ and therefore NAD deficiencies can play a role in eye disease, in fatty liver disease, in heart disease, etc. The way to promote NAD is to take one of the precursors like nicotinamide riboside or NMN.  Ideally you might want to take both of these, but because different companies hold the license to each of these, it would be too expensive to put both into a product. 

NAD originally comes from niacin, vitamin B3.  This is the story of the B vitamins. And then there’s the decrepit, degenerate, benign folic acid that everybody hates.  And then there’s the glorious 5-methyltetrahydrofolic, and then some of these half losers in between like folinic acid.  So it’s the same game.  B3 works its way up to NR and then to NMN and finally to the glory of NAD.  If NAD runs everything in the body, what can you do if you are a hunter gatherer and you don’t eat any food with niacin in it?  You can make niacin from tryptophan.  If you can’t eat any tryptophan, then you can recycle some of your cells, spit out some tryptophan and make it that way. It just takes longer and it takes more energy.  The enzymes that facilitate the jump up to NMN can get knocked out by inflammation and by age, so taking NMN and NR are the best ways to boost your NAD.  But there is also a balance with methylation. After the high phosphate bonds in NAD are broken down, you are left with nicotinamide, which is the non-flushing niacin, which blocks your sirtuins. You need SAM-e to methylate nicotinamide. If you deplete your SAM-e, this creates SAH, which creates Homocysteine, which gives you cardiovascular disease, inflammation, and depression.  So if you want to support NAD production, you also need to take B2, B12 and TMG to stimulate methionine regeneration.

42:36  Sirtuins.  Resveratrol and pterostilbene are both good products to stimulate the sirtuins. Quercetin and fisetin can also stimulate sirtuins and fisetin is also a senolytic.  When David Sinclair originally tried to promote longevity just with resveratrol, it didn’t work because you also need NAD activation or you will get mitochondrial dysfunction and then you also need enough methylation factors as well.

48:33  Senolytics and senescent cells.  A senescent cell is one that has suffered a toxic insult or mitochondrial dysfunction that causes telomere attrition.  Then the mitochondria start releasing pro-inflammatory mediators that diffuse out through the cell and cause growth cycle arrest.  The cell stops reproducing and it just sits there, becoming a zombie cell and it releases pro-inflammatory mediators.  That’s one of the major causes of the propagation of all that inflammation that shrivels us up and makes us old and decrepit.  There are two ways to get rid of these cells. You can reverse them and put them back into growth again and have them repair their mitochondria by having good Nrf2 and AMPK activity that restores the milieu inside the cell and restores the redox potential.  The other way is to get rid of these cells with senolytics, such as with quercetin, fisetin, resveratrol, pterostilbene, or curcumin.  Measuring senolytic activity is a challenge because when you go in and start cutting up these cells, there is a burst of senolytic cytokines, so it looks like there are more senescent cells rather than less and it takes a while to show a decrease.  We can show that senolytics can reverse phenotypic aging, but we can’t measure a decrease in sensecent cells as of yet.

52:38  Spermidine.  This was first isolated from sperm, but now can be derived from wheat germ and other vegetable products. It has a lot of activity for autophagy and mitophagy and senolytic activity.

53:45  Dosages.  Quicksilver products are in a liposomal form, which increases absorption, but they often include much lower dosages of these longevity products than the studies show are effective. So how do we know that we will be getting the proper dosages in these products. Chris explained that their quercetin product has a 25 fold increase in absorption, so 20 gm is equivalent to 500 mg.  Because their BioAge Reversal study, which has yet to be published, showed that using their products for three months was able to reverse the biological aging process, so the dosages used must be effective.

 

 



Dr. Christopher Shade is the founder and CEO of Quicksilver Scientific, which has revolutionized the nutritional supplement industry with their innovative nanoparticles and liposomal delivery system, their heavy metal testing, and their detoxification protocols that have become the standard for many for reducing heavy metals and mycotoxins.  Quicksilver also offers a great suite of age optimization products, including metabolic activators, NAD+, and adaptogenic blends, as well as hormone support.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss and also athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111. Dr. Weitz is also available for video or phone consultations.



 

Podcast Transcript

Dr. Weitz:            Hey, this is Dr. Ben Weitz, host of the Rational Wellness podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness podcast for weekly updates, and to learn more, check out my website, drweitz.com. Thanks for joining me, and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Very exciting today to be talking to one of my favorite guests, Dr. Christopher Shade. Today, we’ll be speaking about longevity. We will be speak about how to delay the aging process to reduce the likelihood of chronic diseases and how to live longer and better, how do we take that aging curve where we see that aging for many is this long slow decline in function and increasing onset of chronic diseases that starts in our 30s and 40s, and turn it into a big rectangle where we maintain a strong level of function for a long period of time, and then quickly drop off.

Today, we’ll be talking about some of the key metabolic pathways and processes that have been identified to play a big role in aging, including AMPK, Nrf2, sirtuins, NAD+, senolytics, as well as hormones and toxins. I recently heard David Sinclair, famed longevity researcher saying on his podcast that these longevity survival pathways are like the Pentagon, which is where the coordinated defense of our country is organized, and we’re trying to make a crank call to the Pentagon for them to send out the troops to defend the body even though there’s no immediate threat. That’s what we’re doing when we are taking nutraceuticals, using drugs off label like metformin, peptides, practice intermittent fasting, cryotherapy in order to stimulate these longevity pathways.

Dr. Christopher Shade is the founder and CEO of Quicksilver Scientific, which has revolutionized the nutritional supplemented in industry with their innovative nanoparticles and liposomal delivery system. They’re a heavy metal testing and they’re detoxification protocols that have become the standard for many for reducing heavy metals and mycotoxins. Quicksilver now offers a new longevity line. I also want to say that after listening to this podcast, you can get 15% off your next order of products from Quicksilver Scientific by using the affiliate code WEITZ15. Chris, thank you so much for joining me again today.

Dr. Shade:           Great to be here, Ben.

Dr. Weitz:            Good. So before we get into what we can do to live longer, what do you think is the … Let’s talk about what’s the difference between chronological age and biological age, and then what’s the best way to measure this.

Dr. Shade:           Yeah. So chronological age, we all know I am 53 right now, but what’s my biological age? There’s a lot of ways that they go about measuring it. For a while, they were looking at different blood markers, and then what’s grown to be the norm is looking at methylation patterns on something called CPG islands in your DNA. So these epigenetic clocks like the original Horvath clock have been used extensively, and it’s funny, they say that they train the clock with people at a certain age more or less function.  So they’re taking people and they’re relating IQ, grip strength, balance, facial aging, IQ all to biological age versus the chronological age. There’s also a new clock. So in fact, as we talk, we’ll talk about a 40-person study where we put them through the paces of one of our systems to detoxify, raise AMPK, raise mitochondrial strength, and we’re able to shift back the biological age in this cohort.

Also, there’s a new one called the DunedinPACE.  Who names these things? Dunedin, if you’re from New Zealand, you’d be like, “Well, yeah, that’s called Miami Beach.” Dunedin is this little beach town at the south of New Zealand. They don’t make Miami beaches there. They make Dunedins.  So they had calibrated this clock. It was between Duke and these guys at the University of Otago and one other place, maybe Oxford. What they did is they worked on the pace of aging. So it’s more of an instantaneous measurement of the pace of your aging, how fast these genes are shutting down over time. So time is this progressive loss of function, and if the loss of function happens faster than the chronological years, then you’re aging at a rapid rate. So your biological age may be 70 when you’re 53.  When the pace of aging is slow, then over the period of time of having a slow pace of aging, then you get to 53 and your biological age is 43 or one of my friends at one of my doctors who prescribes for me, she’s 54 and she registered a 30.

Dr. Weitz:            Really? Wow.

Dr. Shade:           She uses everything. Yeah. So there’s these measures, and what we’re trying to do is extend our health span. You brought it up, run as fast as you can and then quickly. Remember the Blues Brothers? It’s the Blues, and it just drives like mad, and it’s cruising down the highway and the cops are all crashing trying to catch it. It gets to the final courthouse where it’s supposed to stop. They closed the doors and it just falls into a pile of bolts and it’s all over. So that’s what I want it to be, and that’s what we try to have is to have a good health span.

Dr. Weitz:            Right. Exactly. Yeah. So have the results of that study that you did with the biological clock, the study’s been completed?

Dr. Shade:           Yeah. It’s been completed. We got the analysis back. We’re using TruDiagnostic, which is the go-to out there now.

Dr. Weitz:            Right. Yeah. I think I talked to Ryan Smith. He mentioned that you guys were doing a study.

Dr. Shade:           Yeah, yeah. So we finished that all up and the results were great. We got very significant changes in the Horvath clock. We had very significant changes in the pace of aging. We, actually, in three months there, we beat the results from the calorie trial, which was a two month caloric restriction trial. That’s the only thing shown to slow the pace of aging. They pulled back 25% on their calories for two years. They changed the rate of aging, but they didn’t change the absolute clock.  Then looking into subsets, we found really strong changes in immune, and when you’re looking at the genes that were differentially hypomethylated or hypermethylated, a number of these were related to immune cells. So there’s a significant change epigenetically in the monocytes, in the natural killer cells, and what was the other one?  I got it here on the screen behind me.  Coming on now. There it is. B cells. Yeah. Natural killer B cells were the most significant, and then monocytes after that.  So it was really exciting. It was a three-month program. The first month was a detox, but with AMPK activity to it, say 70% Nrf2, 30% AMPK. Second month, we shift to 70% AMPK, 30% Nrf2, and a lot NAD building and membrane buildings, sirtuin activation, getting the mitochondria really clear. So clear things out, detox, then build up metabolic strength. Then the last month, we kept going on that mitochondrial metabolic strength, and we got these great results. As we talk about this more, we’re going to see some of these things are hard to uncouple like Nrf2 and the AMPK. You think they’re separate, but they’re so coregulated.

Then AMPK and sirtuins.  Well, one is just a secondary level of the other.  A lot of this metabolic clarity, I like to call it cardiometabolic efficiency, begins at AMPK. Then if you have enough NAD, you encode that into sirtuins secondarily.  So like mitochondrial biogenesis, you start with AMPK phosphorylation with this PGC1A promoter for mitochondrial biogenesis, but then you have to deacetylate it with sirtuins, which means you have to have enough NAD to do that, and then you get full activation mitochondrial biogenesis, which makes more mitochondria per cell.  So there are almost like these interwoven progressive layers of encoding this higher level metabolism.

Dr. Weitz:            That’s interesting. You mentioned about the immune system function and that’s definitely one of the markers of aging is when we age, the immune system tends to have less and less function, which is why you see-

Dr. Shade:           Senescence.

Dr. Weitz:            Exactly. So I read the Fahy trial in which it was the first trial that they were able to reverse aging, and they also looked at something called thymus involution, which means shrinking of the thymus gland, and they were able to reverse that, and have it as an indicator that the immune system is actually getting stronger rather than weaker, and that’s super important. In fact, we just recently saw what happened during the pandemic to seniors who have a weaker immune system. They weren’t able to fight off the virus as well.

Dr. Shade:           Yup. Yeah. They were really wiped out and it was like, “I wish I could have done some of that thymus work.” I mean, they were imaging them and stuff. We weren’t really set for that, but I’d love to go in deeper and reproduce some of these things, get better blood markers. One of the things we tried to do is get some of the blood markers, but it’s so nascent right now.

Dr. Weitz:            You know what? You should talk to Vojdani about doing a lymphocyte map test because that’s the first test that actually maps out all the specific T cells.

Dr. Shade:           Oh, so Ari has that.

Dr. Weitz:            Yeah. Yes. He just came out with it.

Dr. Shade:           Oh, jeez! That would be great. I’m going to give him a call.

Dr. Weitz:            Yeah, yeah, yeah. So let’s get right to what do we need to do to slow the aging process and live longer. Why don’t we start maybe with AMPK?

Dr. Shade:           Yeah. Well, we have this conceptualization of it that we call the longevity wheel, and it looks like a Star of David. It’s a six point wheel, and it’s got pop, pop, pop, pop, pop, pop, and these are things that you can intervene in. The top spoke of the wheel is AMPK, Nrf2. That’s what we’re going to talk about. Just to fill in, then then the next spoke is NAD. Plus, the next is sirtuins. The next is telomeres. The next is senolytics or senescent cells, and then the neuroendocrine system.  Why is Nrf2 and AMPK at the top, and what are the two, and why do they go together? So Nrf2 we’ve talked about a lot. You and I have talked about it’s this master switch for chemo protection, which when it’s upregulated, well, first it’s called a nuclear transcription factor, and that means that it’s outside the nucleus, and something triggers it to go into the nucleus. Sometimes they just hit signalers on the wall of the nucleus that go in, but the signal gets in and it stimulates transcription or upregulation of genes that go with some family.  For Nrf2, that family is the chemo protection family. So it’s antioxidants, detoxification, protein regulation, getting rid of unfolded proteins, fixing damaged proteins. It’s all cleanup stuff, and that’s Nrf2. We always talked about that because that was always metal detox guy. So you got to raise Nrf2 to bring up all the glutathione genes and get rid of toxins like heavy metals.

Then we did a study or actually [inaudible 00:13:10] down in Houston. He’s a functional medicine doc, did study on our PushCatch liver detox system where he found 82% resolution of fatty liver in one to two months. Just really crazy. We’re like, “Wow! You move toxins out and it does that?”  “Well, no, not exactly. That’s part of moving toxins out, but even if you move all the toxins out at once, that wouldn’t totally happen.”

AMPK then is this trigger, the AMP-kinase, and it’s triggered by certain things like running out of energy, and that would be fasting, carb restriction, exercise, and it also can be triggered by a bunch of nutraceuticals and pharmaceuticals such as metformin, berberine, resveratrol, quercetin. So when you trigger this, now remember, fasting, carb restriction, it triggers you to mobilize and efficiently use your own stored energy resources. So you’re going to mobilize glycogen. You can increase actually glucose transporters, and you’re going to lower insulin resistance, increase insulin sensitivity, and become a clean burning machine.  Then you’re going to reach into your fat. You’re going to mobilize fat. You’re going to turn it into ketones. This is how you go into ketosis and you’re going to use all that for clean energy. It’s why these fasting and exercise get rid of the symptoms of metabolic disease, and insulin resistance, things like that.  So AMPK is part and parcel of that cleaning up, but you’re going to your inner resources. You’re using your inner glycogens or sugar and fat. How are you going to use proteins? You get them through autophagy. So this is super, super important to both detoxification and longevity because what’s autophagy but self-eating. You’re going, you’re taking whole cells, you’re taking deposits. In fact, the burning of the fat out of the fatty liver is called lipophagy, so eating the stored lipids.  If you’re taking a old mitochondria that’s damaged, you do mitophagy. You could be breaking out of golgi apparatus and part of an endoplasmic reticulum. That’s endoreticulophagy, and you’re going to break all that down into its raw materials and you’re going to reuse it, and that includes amino acids and fatty acids, nucleic acids even if you’re taking whole cells. So it’s a recycling system. It’s the inner detoxification for your broken inner parts. So Nrf2 is more taking away environmental toxins and AMPK is more clearing out your own accumulations of waste, and that also includes unfolded proteins.

When you’re making proteins all the time, you don’t make them right all the time. And you store the ones that aren’t properly made in these vacuoles, and eventually, if you don’t get rid of them, it’s like taking the trash out of your house. Your house fills up with garbage. So Nrf2 is this environmental cleanup. AMPK is this biological cleanup, and this raising yourself up to a higher metabolic efficiency.

Dr. Weitz:            This happens because the body senses there aren’t enough amino acids around to make up the proteins they need. So that’s why the body starts recycling these other pieces of the cells.

Dr. Shade:           Yeah, essentially. Now, there’s this switch that’s intimately engaged in this, and this is mTOR, the mammalian target of rapamycin. So rapamycin was the first cancer drug that was ever really good for you because it would block this thing called mTOR. So mTOR has a forward direction and a blocked. The forward direction is anabolic and it’s pro-growth and it builds mass and it puts on mass, but we know if we just put on mass all the time, we’re going to get sloppy and messy and dirty. I mean, even weight lifters put on mass and then they cut it back down. All right?  So if you’re growing all the time, you’re prone to cardiovascular stuff and cancer and stuff. So you need a block to that. So when you block it, then you go inward and you recycle your own amino acids, you use your fats, you burn all that. So what drives it forward and what blocks it? So the things that drive it forward are insulin and branched-chain amino acids. The branched-chain amino acids are what goes back to you, sensing that you don’t have enough amino acids around and you start recycling old parts.

So when we’re eating carbs and protein all the time, we’re gaining mass. This is part of why keto was so therapeutic, where paleo, some people it worked and some people didn’t because they took in so much protein they didn’t get as much of the mTOR blocking, but then we have things like intermittent fasting. If we overlay some of these chemical triggers for it, maybe you’re using off-label metformin or maybe you’re using something like our product AMPK Charge or Keto Before 6, and even of our Liver Sauce, that’s why the Liver Sauce gets rid of the fatty liver so well.  Yeah, it was moving toxins and the Nrf2 upregulator, but the quercetin, the luteolin, the milk thistle, those were all strong upregulators of AMPK. So we can take these AMPK activators while we’re intermittent fasting and get this flush of activity. In fact, we used to call the product Keto Before 6 because you could be keto by day and they need carbs at night and then do it again the next day. So you’re getting some of both worlds.

Dr. Weitz:            You think about this argument because I was just talking to somebody about diabetes this morning and she was advocating for not eating a lot of fat because some of the data indicates that saturated fat reduces insulin sensitivity.

Dr. Shade:           I think it’s going to come down to what your blend of macros are, how much saturated, and are we talking about Crisco or are we talking about these beef tallow? Those are both saturated fats, and some are very strongly pro-inflammatory and some aren’t, and then there’s some other-

Dr. Weitz:            There’s a group of folks who are advocating, some of them are advocating a vegan diet, but they’re countering the lower carb diet, often advocated now for diabetics saying, “No, no. If you eat a higher fat diet, it impedes insulin sensitivity.”

Dr. Shade:           I think it’s going to come down to a couple of factors that they may not be looking at. Now, one of the subjects that’s coming up really hot and heavy right now is uric acid, and you’ll see Perlmutter is talking about. Rick Johnson is one of the masters of that. We’re going to have them here lecturing at our Colorado Functional Forum in April. I’m actually roping then into helping me prove out some of the products that we’re making for uric acid blocking.  So then this is going to bring our AMPK discussion back to this switch. You’ll see in Perlmutter’s book, Drop Acid, he talks about is this primal switch. When your ATP goes low, you can go one or two ways. You can go the AMPK route or the AMPD route. AMPK goes in and mobilizes resources, cleans up, and gives you insulin sensitivity. It gets rid resistance. AMPD goes exactly the opposite path. It’s made to get you fat. AMPK is taking off fat. AMPD is gaining fat. It’s breaking ATP down instead of regenerating it as in the AMPK pathway. You’re burning more energy to regenerate your ATP here. Here, you burn off the AMP into xanthene, and then xanthene oxidase turns into uric acid.  Uric acid comes back around and blocks AMPK and keeps you stuck on the AMPD pathway. Now, the AMPD pathway generating all this uric acid, the uric acid is creating mitochondrial stress and creating free radical damage inside the mitochondria, and it’s heavily associated with cardiovascular disease, and more importantly, early onset dementia.

So if you’re eating fat and other things that you’re doing like maybe you’re eating high fat but not restricting carb enough or you are prone to uric acid, maybe you need more polyphenols in your diet, you need more vegetables to block that path or you’re eating too much salt, you’re drinking too much alcohol, the biggest culprit is just not having enough water keeps you always down that path.  So the fat then is going to become inflammatory fat instead of clean burning fat, which is over here. So I think one of the things that I think I’m going to be advocating is that you got your uric acid meter, your keto meter, and your sugar meter, and you’re tuning yourself in so that you’re going down the AMPK side.

Dr. Weitz:            Interesting. I was going down the AMPK rabbit hole this weekend and I found one article that said that AMPK appears to reduce cancer risk by switching off cellular growth pathways, but if there is already cancer, the AMPK might be able to protect the cancer cells against stresses, such as shortage of oxygen or oxidative stress.

Dr. Shade:           Yeah. So is it going to protect against apoptosis? So it can keep you from going into apoptosis and maybe help the survival mechanism, but realize that it’s the biggest freaking trap in the world. Cancer and fear of cancer is the biggest impediment to health because every single thing that makes you live long makes cancer live long.  Now, just shut the damn argument down for a second, then bring it back and say, “What has cancer done that is genius? Cancer has immortalized itself. How does it immortalize itself? It upregulates glutathione. It upregulates NAD production. It upregulates growth hormone production. It controls AMPK and all these different pathways towards its longevity.  Then everybody’s like, “Well, what if I already have cancer? Then any of these things that help my longevity are going to help the longevity of my cancer.” Well, your cancer is going to show itself at some point and then you’re going to go after it, and it’s a certain way that you go after it, but having a healthy AMPK is going to prevent you from ever getting it in the first place. Then being afraid of doing these things that promote longevity, in case there’s some tumor somewhere in you, I don’t know, go get a big scan or something because it just becomes such a trap. Don’t you think?

Dr. Weitz:            Yeah. I’m sure. It’s also, I’m sure, the balance and the double edged sword of things that-

Dr. Shade:           Oh, hyaluronic acid, that’s another thing that cancer has a lot of. So all of a sudden, everything that immortalized cells have a lot of becomes a death trap. Yet, that’s all the stuff that makes you live longer. So yeah, that may be tactically true, but I mean, nobody is saying that when you’re taking berberine and quercetin and EGCD, I mean, there’s people using those as therapeutics for cancer. So I don’t think you’re in any risk of all of a sudden you’re going to go off the deep end.

Dr. Weitz:            So what’s the best way to stimulate the AMPK? What are the best strategies here?

Dr. Shade:           Yeah. So I love intermittent fasting. I think it’s a great thing. Some women it’s a little bit hard, but get as much fasting as you can, then workout fasted. Add in the AMPK activators. Now, here, as a broad brush, almost every plant chemical has AMPK activation activity to it, and including the adaptogens and all those plants that we love a lot of, spices-

Dr. Weitz:            We want to take the ones that are going to be most efficient and take the right dosage.

Dr. Shade:           Yeah, so some of the really strong ones, berberine, resveratrol, quercetin. Quercetin’s such a multicomponent for us and Nrf2, AMPK, sirtuins. It’s a senolytic. That’s a really, really good one. Then things like milk thistle. Part of that is AMPK and sirtuin activation of the liver. A lot of these things that are AMPK activators are also sirtuin activators.  So there’s this whole grouping of things that are really good for your metabolism. So you take those when you’re fasted or at least don’t have a lot of carb in you and maybe get some exercise in.  Ben Greenfield says the strongest AMPK activation are HIITs. He says 30 seconds as hard as you possibly can, and then I think he said four minutes of rest and then 30 seconds as hard as you possibly can, and then 30 minutes of rest, but anyway that you stack some use and exercise, lack of carbs and this and the AMPK activators together, you’re going to get a lot out of that.

Morning is naturally more AMPK than night is. We’ve just gone through the fasting, we’ve already got the fasting primed. Like in the skin, it’s more breaking down. It’s doing autophagy in the morning, and at night, you’re sleeping and it’s rebuilding everything. So I like to stack the AMPK activity into the morning and build up at night. So my carbs, those come at night and I intermittent the fast in the morning. Lunch, hopefully it’s salad and some protein and still low carb, but that varies a little bit depending on where I am. There’ll be times where I’m really cleaning up and then times maybe I just had stem cells or exosomes and I’m a little more anabolic, and then you’ll go more in.  I think understanding those two poles of the day, AM and PM are naturally that way a little bit, and then the pendulum of your life, “I’m trying to build a little bit, I’m trying to cut down and clean a little bit,” and I definitely go into times where I’m like, “Uh-oh. This baby is building up a little bit,” and then I really start fasting hard, and it cleans up really quick.

Dr. Weitz:            You just mentioned exosomes and stem cells. Have you gotten into those?

Dr. Shade:           Oh, yeah, yeah. I’ve gone offshore down to Columbia and done cord blood cells twice. I do exosomes every couple of months.

Dr. Weitz:            Which exosomes do you do?

Dr. Shade:           Which? I use Kimera. I mean, there’s not a lot of them out there. Kimera just shifted to doing only cosmetic. That window is closing a little bit in the FDA. So my freezer is filling up with them until there’s something else. There’s a lot of movement in peptides, too. Those are real good regenerative.

Dr. Weitz:            Sinclair was talking about he had some friends apparently who have a machine where they can manufacture their own peptides at their home.

Dr. Shade:           What? That’s crazy.

Dr. Weitz:            I don’t know. Probably very wealthy friends, but-

Dr. Shade:           Yes. Yes, very, very wealthy, “I have my peptide generator machine here. I got it used for $500,000 from Oxford University.”

Dr. Weitz:            So let’s talk about NAD+, which is this signaling molecule that’s present in the body for energy production, cellular energy, DNA repair.

Dr. Shade:           Yeah. So NAD is awesome, and it’s just the multiple levels at which it works are just crazy. There’s so many levels that are even understandable, but at its most basic level, it’s going back and forth between NAD+, the oxidized form, and NADH, the reduced form. It’s doing that by oxidizing your inputs of energy. That would be carbs and lipids. It’s taking the electrons away from them as your carbs make their way off to CO2 and at each little part of the citric acid cycle, all these different breakdowns. It’s NAD+. It’s taking to electrons, becoming NADH, and then it’s going into the electron transport chain, and it’s dropping the electrons into the high energy electron transport chain and leaving the proton there. That’s eventually going to be pumped across the membrane, form that proton gradient, and come back through ATP synthase, and drive ATP formation.  So it’s shuttling energy from the sun, which is what built your carbs and your lipids and bringing it in to make ATP. All right? So if it just did that, it would be a great molecule, but it does so much else.

So then it’s also the co-factor in sirtuins. So sirtuins are deacetylases, and acetyl groups are turning on or off different protein, and there’s the good anti-aging things and to turn them on, you deacetylate them, and then the bad anti-aging things, and to turn them on, you acetylate them. So when the acetyl groups are on, the sirtuin or a lot of the anti-aging things like FOXOs are off and things like P53, which makes more senescence, and why would you even do this stuff? It’s to stop cancer growth.  So a lot of the slowing down and winding down of the body is to make sure that cancer doesn’t take off and get on a run. So the sirtuins are shifting you over this cleaner building through this deacetylase activity. So we think about things like resveratrol and pterostilbene and quercetin and sirtuin activators, but actually, NAD is the initial activator and it fits right into this hole in the sirtuin and activates it.

Then there’s another hole where the sirtuin activating compounds. You’ll see Sinclair call them STACs. They fit into another part in the molecule and hyperactivated, and get it super wound up. So NAD is essential for having these sirtuins go on, and then it’s also essential for gene repair. So as we get older, we’re having assaults on our genes all the time and, say I get exposed to some radiation and it damages a gene. There’s something called a PARP that’s going to go in and try to fix it, and it has to use the energy of NAD to fix.  So it’s sucking anything that damages your genes, sucks a ton of NAD in there. Now, what’s that going to do? It’s going to take the NAD away from the mitochondria so the mitochondria can’t complete the electron transport chain, and you’re lowering energy. It’s going to take things away from sirtuins, so then the sirtuins aren’t going to be deacetylating the good genes, and so it’s sucking all this repair over there.

There’s also CD38. One of the good things that they do is seal up tight junctions when you’re getting leaky gut or leaky blood-brain barrier or leaky liver. So that’s sucking NAD into that activity, too. So there’s this hole, and then there’s some other ones that I don’t to understand as much into how it’s deciding which genes are turned on and off, so this epigenetic regulation of the epigenome, what we can turn on and what we can turn off. It’s basically, do we have NAD despair?  We’re going to turn on the good. Do we not?  We’re going to just hold our own.  We’re going to hold the fort down and make sure we’re at just default functioning.  When we’re in default functioning too long, there’s a lot of theories of cancer emerging from in that default functioning, this explosion or this overgrowth.

So NAD is doing all these things throughout every organ, and you could relate NAD deficiencies to eye disease, liver disease. I mean, you waste out your NAD, fatty liver is the first thing that you get, heart disease, every different organ. So NAD is really, really a powerhouse for driving the whole body and then driving what are the expressions of your genome. Remember, this is the consciousness of the body is deciding. You have multiple pathways, multiple possibilities for your consciousness to choose from in your physiological outcomes. NAD is right in that decision tree of what’s possible and what’s not possible.

Dr. Weitz:            A way to promote NAD is to take one of the precursors like nicotinamide riboside or NMN, and there seems to be two camps and debates as to which one is more effective.

Dr. Shade:           Yeah. Well, that’s just basically because humans like to be on this camp or the other camp. You’re a freaking liberal or you’re a freaking conservative, and you’re demonized either way.  It’s just, “Oh, are you NR or NMN?”  Look, where did all this still come from?  It comes from Sinclair.  Then he’s loathed to hear this, but his advisor, Leonard Guarente and him had a little rift.  So Guarente is all about pterostilbene and NR and has MLM product doing that, and Sinclair is all about resveratrol and NMN and had some shit on that.  So they got this little war like, “Which one is better?”  They’re both good.  Really, you want both of them probably in a product, but you can never get a license to get both of them because there’s intellectual property around it.  So we have a liposome of NMN. I made a liposome for Crominex of NR. It was freaking great, but they didn’t want it. So I can’t do that, and so I just do the NMN, but in the liposome, it’s freaking great. So the camp thing is silly there, but let’s get back to how you build that NAD and where does NAD come from normally? So NAD, nicotinamide adenine dinucleotide.

Dr. Weitz:            Niacin.

Dr. Shade:           Right, right. So this is the high level of B3 and you look at it like the story of the B vitamins. There’s the decrepit, degenerate, benign folic acid. Everybody hates it. It does nothing but lay vape to the universe, and then there’s the glorious 5-methyltetrahydrofolic, and then some of these half losers in between like folinic acid. So it’s the same game. B3 works its way up to the glory of NAD, and right before that you’re NMN, and right before that you’re NR.  So that’s where all this sequences, but as we get all, it’s hard to take the degenerate vitamins and make them into the glory. You’re just not as good of it, but then you think, if NAD runs everything in your body, what are you going to do if you don’t have some food, you’re a hunter gatherer and there’s nothing with niacin in it?  Well, you can make it from the de novo pathway where you make it from tryptophan.  If you can’t eat any tryptophan, you just recycle some of your cells, spit out some tryptophan, and you take it through a bunch of pathways. It just takes longer.  It takes more energy.  The enzymes to get up that last jump, it’s actually the jump up to NMN is that one gets knocked out by inflammation, knocked out by being old.  Anything that makes you sick makes that doesn’t work.  So coming in with NMN and NR are the best ways to instantly get you up to that NAD.

Then what people always miss is the balance with methylation. So NAD, all right, great, it’s going to activate the sirtuin, killer. What’s formed from that? It breaks down and all those high phosphate bonds are broken, energy goes into the system, and you’re left with nicotinamide.  Remember, that’s the non-flushing niacin. Well, nicotinamide blocks sirtuins. So you can’t build up this pool and nicotinamide need to drive it back up into NAD, but if you’re having a hard time doing that, then you’re blocking all your sirtuins.  So you got this circle called the salvage pathway, and it’s going down here and getting stuck.  So what happens then?  You pee it out, but to pee it out, you have to make it into methylnicotinamide. Where do you get the methyl group?  SAM-e?  So SAM-e methylates nicotinamide, you pee it away. You come in with a fresh NMN or NR and you keep driving this cycle, but you’re bringing constant input out and leaving stuff out the back. In doing that, you’re depleting your SAM-e and creating SAH, which creates then homocysteine. So if you keep driving that, you’re going to build up homocysteine and deplete SAM-e. Then what does homocysteine do? That gives you cardiovascular disease and you have lower methylation, and then you’re depressed and you’re inflamed and all this shit. So then you got to stimulate both the methionine cycle, which is going to regenerate methionine from homocystine and that’s interlaced with the folate cycle.  So you want to stimulate MTHFR, which you do with B2, and you want to stimulate the methionine regeneration. So basically, your co-factors you need, you need B2, you need B12, and TMG, and the pauper’s pathway to get there is just lots of TMG.  So if you’re going to drive NR or NMN, you’ve got to support methylation so those two are balanced.

 



Dr. Weitz:  We’ve been having a fascinating discussion, but I’d like to take a minute to tell you about one of our sponsors for today’s podcast. Are you ready to up level your health? Check out the longevity products from Quicksilver Scientific. They’ve been making premium nanoparticle delivery supplements since 2006, and they have a great suite of age optimization products, including metabolic activators, NAD+, and adaptogenic blends, as well as hormone support to name a few. You don’t have to look any further for comprehensive age optimization supplements with amazing bioavailability and absorption capabilities. To get 15% off your next order of Quicksilver Scientific products, please use the affiliate code WEITZ15, that’s my last name, WEITZ15, at checkout. Now, let’s get back to the discussion.

 



 

Dr. Weitz:            It’s interesting that you were talking about acetylation, and there’s so much focus on epigenetics as being all about methylation. I wonder if we just haven’t gotten to the research on acetylation and some of these other pathways.

Dr. Shade:           That’s histone acetylation. So there’s methylation and histone acetylation. Those are the two main epigenetic factors, and that’s actually probably how NAD controls so much of the epigenome, but it’s the methylation over time is the thing that is constantly increasing, and that’s the thing that you can do the clock with. They don’t have a clock with histone acetylation, and so they just ignore it, and everything’s about methylation. We all can run to one side and some people are worried, “Oh, my God! If I take too much methylation supplements, I’m going to methylate all my genome.”  In Kara Fitzgerald’s work, she’s a little worried about that, but there’s all this balance, and that’s great. I’m glad that you pointed that out because why aren’t we talking about that side of the whole deal because you look up epigenetics, those are the two fundamental ways that you turn on and turn off different gene sets. It’s important sometimes to shut things off and sometimes to open them up, and you’ve got the balance and you’re allowing both sides and allowing the enzymes to control all that. Then everything’s going to be great.

Dr. Weitz:            So in terms of sirtuins, you just mentioned resveratrol, you mentioned pterostilbene, there’s something called fisetin. What do you think about some of those different ways of stimulating sirtuins?

Dr. Shade:           I think they’re all good as long as you’re feeding in enough NAD. So resveratrol versus pterostilbene, I think they’re fundamentally identical. Pterostilbene has better data going through the gut because it’s got better absorption, but at a cellular level, I don’t think it’s any better. We’re going with nanoemulsions. I don’t really think it matters. We have a product coming out with both of them in it. Till now, we’ve been using mostly resveratrol because pterostilbene was so overpriced, but now it got better so now we’re using both.  Quercetin, I guess fisetin does it, too, but fisetin is also a senolytic. So then we’re going to talk about senolytics as well, but there’s all these things raise sirtuin activity, but if you don’t have enough NAD, here’s where there’s some conflicting data about resveratrol. Resveratrol, they tried to make that into a drug and they ran into phase two trials where some people were getting screwed up by it. Now, they were taking massive doses and trying to drive everything with that. They weren’t even thinking about supporting NAD. So here’s what happens. So I said that-

Dr. Weitz:            By the way, is this where … I remember years ago Sinclair was this guy who his big thing was … We know that caloric restriction seems to have this longevity benefit, but who really wants to live like that, eating 30% or 40% of your calories less than you should, and then the worst tragedy would be live that way like Roy Walford did and suffer, and have this miserable life and then die of ALS in your 70s, anyway, but I remember-

Dr. Shade:           So we’re trying to get to … All right. So he’s like, “Well, then we’re just going to pump the resveratrol in,” because, yeah, like Valter Longo, he points to these people who lived to 105, 110 in the mountains and they’re 4’5″, they’ve never smoked a pack of cigarettes, they had sex once in their life for procreation, and they don’t drink, and they eat a thimble full of food every day. He’s like, “Well, that’s not how I want to live.” So yeah, this is the grail. How do we get all this, right?

Dr. Weitz:            Right.

Dr. Shade:           True to anybody out of academia, let’s do a one hit wonder and cut to the chase. It’s going to take a couple of things all in balance. So he tried to just run it on resveratrol in the beginning, and then they had some studies that were like, “Ah, I don’t think this is working.”  Here’s what happens. If you don’t have enough … Remember I said the sirtuin that get activated has a place for NAD, which is the primary space, it’s necessary, and then it has a secondary space for a sirtuin-activating compound. Well, it turns out if you just jam in tons of sirtuin-activating compounds, it almost sucks the NAD in like a magnet. What does it do? It takes it away from the mitochondria. So then the mitochondria start misfiring. So you have all these sirtuins activating and you have mitochondrial dysfunction.  You can’t drive it with one. If you want to drive the sirtuin-activating compounds, you need to supply enough substrate to have NAD balancing it. Then if you’re going to do that, you need enough methylation factors to balance that, but that’s not that complex of an equation, but if you try to just press one of the damn buttons, it doesn’t work so well.

Dr. Weitz:            Right. Yeah. I think to this day Sinclair takes a gram of resveratrol a day.

Dr. Shade:           Yeah. Yeah, he does, and he takes a gram of NMN, and he probably takes some maltenes. So he’s got it all held up there, but in the beginning, they tried to do it just with the resveratrol. Notice, that was where all his work started. The last couple of years, he’s been all NAD. So he must have been like, “Yeah. What am I missing here?” and then he got all into NAD.

Dr. Weitz:            Yeah. I remember there was a point at which he was the guy who was going to solve this longevity problem, and then there was a point at which it’s like, “Yeah. That’s it. That didn’t work. Forget it.”

Dr. Shade:           Yeah, but don’t throw the baby out with the bath water, just what did we have to balance with that. I had this great paper I found that was biochemical archeology. They were talking about the balance between NAD and methylation, and they were talking about these different societies that grew up and which ones thrived and how the balance of methylation and NAD gave them this power. They were describing if you’re low NAD to begin with, you’re not going to get anywhere, but if you’re high enough NAD to get somewhere, then later in life, if you’re imbalance one way or the other, you get Parkinson’s either way, but there are different Parkinson’s. So there’s the high NAD low methylation Parkinson’s and the high methylation low NAD Parkinson’s, and then there’s the balance. When you balance the two, you raise the whole human potential up. I mean, that’s beautiful.

Dr. Weitz:            That’s beautiful.

Dr. Shade:           The language, spreading fields of proteinopathies, which are uncoupling electron flow from proton flow and spreading fields of proteinopathies leading to the metabolic diseases and degenerative diseases of cancer and neurodegenerative problems. Yeah, exactly. Balance that thing, raise them both up, and just hit hard.

Dr. Weitz:            Let’s talk about senolytics and senescent cells, they’re called zombie cells because they don’t function the way they’re supposed to.

Dr. Shade:           Yeah. So the senescent cell, now, it’s a mitochondrial dysfunction or a toxic insult that causes telomere attrition, that then progresses to mitochondrial dysfunction, and then the mitochondria start releasing these pro-inflammatory mediators that diffuse out through the cell. The cell stops, it goes into growth cycle arrest, stops reproducing, and it just sits there, and it releases pro-inflammatory mediators, which are spreading decaying inflammatory fields throughout the body, but they’re also recruiting other cells into this decaying inflammatory field.  That’s one of the major causes of the propagation of all that inflammation that shrivels us up and makes us old and decrepit. So the idea is to get rid of these cells. So there’s two ways. You can reverse them and put them back into growth again and have them repair their mitochondria, and that’s if they haven’t gotten too deep in, and that’s by having good Nrf2 and AMPK activity that restores the milieu inside the cell, restores the redox potential down to highly reduced, and it can come back on and reboot.

The other is to kill it, and that senolytics, senescent cell. Lysis is cutter. So senolytics, quercetin was the archetypal senolytic. Fisetin or fisetin came on as a really good one as well, but even things like resveratrol and pterostilbene and curcumin have some of this senolytic activity.  Now, measuring this is really a bit of a challenge. This is because when you come in with this, well, first, you’re measuring some of the cytokines, the inflammatory molecules that are coming out of these cells, but if you go in and cut a bunch open and kill them, there’s a burst of senolytic cytokines that come into the system. So the senescent marker actually goes way up when you’re addressing the whole thing, and then how long does it to take to come down?  So in our three-month trial, it went up and we were using tons of senolytics. It was quercetin and everything that we gave them, but we got the good shift in the genes. We just have to come up with more markers around that, but some of the trials that have been used with really high end design senolytics have really been able to reverse phenotypic aging in a lot of animals and in humans. So that’s a really exciting thing.  There’s a really cool question in there. Why the hell would you ever do that? Why would your cell ever do that? Well, one thing is for cancer surveillance. “Oh, my God! I don’t want to grow like mad with cancer. I’m just going to shut down the cell.” All right? So P53s do that, but then they don’t know how to get it out of there.

So then there’s acute versus chronic. Acute senescence say, “Boom! Ow! I just hit the edge of that desk there. I just broke a bunch of tissue in there.” All right? So now, there’s a bunch of cells in there that are going to go into senescence, and they’re going to sing the song of senescence really loudly all in concert. So it’s not just whispers of senescence. It’s like … and the immune system is going to hear the signal. It’s going to come in. It’s going to eat them.  So you can grow new tissue there. So that’s a programmed senescence to rebuild damage tissue, but when they’re spread all over the place, it’s just whispers, and the sound of inflammation may be loud, but the immune system can’t pinpoint where it came from and so it’s not going to clean up the mess. So that’s just one of the side effects of aging. So now we know that we can go in and clean out some of those cells and stop that inflammaging signal.

Dr. Weitz:            I guess there’s another compound now called spermidine that’s getting some play.

Dr. Shade:           Yeah. Spermidine, isolated from sperm. Hence, the name spermidine. You’re like, “Well, they must have got it from sperm whales. No, they got it from sperm, semen, and there’s a lot of spermidine in semen, and it’s-

Dr. Weitz:            Apparently, they can get it from wheat germ and all these other vegetable products, too.

Dr. Shade:           Well, that’s where they first got it. I mean, they’re not like lining guys up and-

Dr. Weitz:            Right. That’s where the name came from. Yeah.

Dr. Shade:           That’s where the name came from. Dr. Ruth Westheimer, remember, the sexologist, she said, “Oh, there’s so much good for things for you in sperm,” little Austrian voice, but apparently, she had the goods on spermidine.

Dr. Weitz:            It’s not as good for marketing, though.

Dr. Shade:           No, no. Every time I’m about to put in a product I’m like, “God, I’m going to have to listen to all this shit about this,” and it costs some fortune, but spermidine is really good for working on autophagy and mitophagy and senolytic activity. So I’m sifting through all the exact uses of that, but that’s looking like that’s going to be a really promising one.

Dr. Weitz:            Now, what about dosage? You read these studies and they say you have to have 250 milligrams of resveratrol, and your products, because they’re liposomal, have a lower dosage of a lot of these products. How do we know that’s the right dosage?

Dr. Shade:           Yeah. Our quercetin has a 25-fold increase in absorption. “Oh, there’s 20 milligrams of quercetin.” I’m like, “Yeah, multiply that by 25. That’s a lot of question.” The beauty of it is it goes right into the blood, and the levels in the blood, even at the 20 milligram level, you’re going to beat out 500 milligrams because it all goes in at once. It gets the peak dose in there. You think of a senolytic, it’s almost like chemotherapeutic. You need to peak dose to activate that, Nrf2, AMPK. Peak doses activate that. So it’s a beautiful way to do it.  Now, exactly what the right dose is? Even though, “Oh, you need 250 milligrams. This study …” we’re still really working that out. I know that the dosage schedule that we laid out in our Bio-Age Reversal works because I was able to shift the whole genome plaque back. So I know that’s working, I know that I saw the markers of senolytic activity go up that I was breaking down these cells, but it’s going to be a few more years of really getting the right assays, working out, what we really want to see to know exactly what it is, but I have people go on these little campaigns, “We’re going to detox for a while and maybe we’re taking 40 milligrams a day, 50 milligrams a day, I’m stacking a couple of things together,” and there you’re actually getting maybe a few hundred milligrams a day in these nano forms.  I know that we’re triggering it. I know we shift fatty liver. I know we’re upregulating Nrf2. I know we’re shifting the genome. So I know that these dosages are working, but will we get to more specific dosages, more clarity to them? Yeah, we definitely will, but I also did do sirtuin upregulation tests on people using peripheral blood mononuclear cells. So the white blood cells are the only blood cells that are really cells. Red blood cells, they don’t have a nucleus, they don’t have mitochondria. They’re not cells. They’re just oxygen transport. So you do it in whites.

This is really nice. We saw on a single dose of it was basically our AMPK charge, but it was a little bit different. It’s a product we’re going to come out soon. Single dose, over about two, three hours, the sirtuins upregulated about three, fourfold and they lasted 24 hours. So it was really nice because I like people to do these things in spurts and then take a couple day off, go a couple days, take a few days off because you’re stimulating the system, let it come back down, stimulate it, let it come back down.  So the way that we’re using these and we’re dosing them, we see the signals, we see the changes. We know we’re working well on them, but I want to get to a point where I’m like, “This dose for that, that dose for that, that dose for that.”

Dr. Weitz:            I also have a request. Is there a way that you could put your products in a capsule form as well as an alternative to some of the liquids?

Dr. Shade:           Yeah, and we did start doing that. They’re called SED systems, self-emulsifying delivery systems. So our CDDPN is that way. Micromanager, which is more for controlling microbial growth, but we are doing one that’s a sirtuin activator in a capsule and there’s more that capsule activity to come. In fact, maybe as we work out some of the senescent stuff, maybe we’ll do a senolytic in there as well.

Dr. Weitz:            Yeah, that would be great because some people prefer the liquids. Other people, they don’t like to taste and you have to go to the fridge all the time. So they don’t travel as well and stuff.

Dr. Shade:           Yeah. Yeah. So we are doing that.

Dr. Weitz:            Cool. Excellent. So any final thoughts and-

Dr. Shade:           No, we did good. We covered a lot of stuff.

Dr. Weitz:            Yes, we did.

Dr. Shade:           The only other thing we didn’t really talk about is membrane health, and the membranes are … We’re talking about phosphatidylcholine bilayers that are housing the cell, ones that are making up the mitochondria, ones that are making up the endoplasmic reticulum. Everybody loves the mitochondria, but the endoplasmic reticulum is this big, huge folded over just layer and layer and layer and layer and layer of membrane that are creating what I call the membrane potential, which is a power potential across, it’s a charge potential across a membrane that actually drives the number of the reactions or the little motors like ATP synthase that are in the membranes.

Then the membranous organelles all communicate one to another, and the quarterback of that is the endoplasmic reticulum, and they actually exchange signals and discuss between the mitochondria, the golgi apparatus, the endoplasmic curriculum with signals coming from the extracellular environment through the cellular membrane, all that decision making going into the nucleus and signaling which genes to be manifest within the nucleus depending on the availability of inputs and the extracellular compartments and the health of the intracellular compartments.

So it’s a really beautiful communication structure and building membranes with phospholipids like phosphatidylcholine is one of the best ways to build the health of the membranes, and that was my one fun thing when I went on to a retreat with Joe Mercola, Ben Greenfield, Robert Slovak, Emily Givler, Bob Miller, and a couple other people. Joe brought his bioimpedance meter that was for measuring membrane health and he measured everybody there. Then I was the last one to get there, and Emily was like, “Chris is going to win.”  Joe’s like, “Why?”  She’s like, “Membranes. PC. He’s the PC guy.”  Of course, I beat everybody and I had these great numbers there because everything that I take has phosphatidylcholine, and you can buy it directly. You can buy our Pure PC or our Membrane Mend or various ways to get PC, but building the membrane is the one thing, and that was in Europe. That was the first mitochondrial therapy was lipid replacement therapy. There was those old injectables, Lipostabil and capsules of PC.  So the membrane is a big modulator of the power of the system. So we’ve been talking about cleaning up, burning cleanly, powering up the system, the NAD, the sirtuins, getting rid of the senescent cells, and just having a high powered system and the transducer of the power or the capacitor of the power being the membrane.

Dr. Weitz:            So the main ways to stimulate the membrane is with phosphatidylcholine, fish oil. What else?

Dr. Shade:           Yeah, those good fats there. Those are the core, but where else can you get PC? So you can get it from lecithin, but don’t get cheap soy lecithin, even cheap sunflower lecithin. Go for the professional grades. We have it down into a nano form in the Pure PC and the astaxanthin, and then these really good carotenoids for protecting the membranes, and that would be like astaxanthins, zeaxanthin, lycopene, tocotrienol. Those are super good, and then other natural source. When I first started into this and it was watching a lot of Dietrich Klinghardt, egg yolk, organic egg yolks. Six of those give you a massive PC dose.

Dr. Weitz:            Interesting. There’s some cardiovascular literature to say that choline can raise your TMAO levels and that can be problematic depending upon your microbiome.

Dr. Shade:           Yeah. It’s all backward. Your microbiome turns choline into TMAO, but the TMAO isn’t actually what’s causing the cardiovascular disease. What gives you the biggest spike of TMAO of any food in our biosphere? Do you know?

Dr. Weitz:            Salmon.

Dr. Shade:           Yeah, fish. Fish are all at the top, and those are the heart healthy ones. So the thing is the heavy meat eaters get a microbiome that makes TMAO, but they make a whole lot of other things. That firmicutes/bacteroidetes blend goes in the wrong direction when you’re not eating enough plant matter, and there’s all these other things that happen that move towards the inflammation of the cardiovascular disease. TMAO is just a side player in that. I don’t believe it’s driving it at all. In fact, after that paper came out, there was a bunch of Swedes, I think, wrote a big response to it called Something Fishy About TMAO.

Dr. Weitz:            Right. Yeah. It’s never made any sense to me, but it is out there supporting membranes, and then you also talk about the importance of the hypothalamic pituitary adrenal access.

Dr. Shade:           Yeah. That’s coordinating mitochondrial health. That’s coordinating all of your hormone health. Yeah, we can do hormone replacement, but adaptogens are probably the best way to just make sure that all of that is working really well, whether you’re taking exogenous hormones or not. One of the things that’s cool about ginseng is it raises the receptor density for androgens and estrogens. So as we get old, our androgens and estrogens are going down, but if our hormone density goes up or our hormone receptor density goes up, the activity, the androgenicity is a interaction between the hormone level and the receptor density.  So if you double your receptor density, you double the reactivity to a given level of hormones, and that’s one of the beauties of the adaptogens. In fact, the adaptogens, all the good ones, the astragalosides, the ginsenosides, withanolides, which are from ashwagandha, gypenosides from gynostemma, all of them have the same steroid backbone of your hormones. So they’re obviously meant to be interacting with your hormone system and affecting receptor sites, and that’s why they work so good on that.

Dr. Weitz:            Yeah. I wanted to mention the Astragalus situation because I know there’s that TA-65 supplement out there, which is this, I guess, specialized form of Astragalus, but can we get that from other forms of Astragalus?

Dr. Shade:           So there’s is cycloastragenol. Now, that’s what’s come out. There was a freedom of information act request to get the formula there, and it was cycloastragenol. Now, there may be some synergistic factor in there, but cycloastragenol is the core. So in our Longevity Elite, we have all these ginsenosides, and we have special astragalosides. We have cycloastragenol and astragaloside 4. Astragaloside 4 upregulates klotho, which is a regenerative molecule you make in kidneys and brain.  The cycloastragenol works for telomeres activation to lengthen telomeres, but one of the things … Dr. Raffaele has been working with TA-65 a lot, and he thinks that … See, cyclo is also a killer senolytic, and he thinks that a lot of the senolytic activity is responsible for the regenerative capacity of TA and the astragaloside. So now, they used to have the market cornered. Now, there’s other ways to find cycloastragenol and astragaloside 4, but whether it’s working at a telomere level, a senolytic level or both seems to be good. That seems to be good is freaking great.

Dr. Weitz:            It’s interesting how hormones started out to be one of the first places a lot of doctors and researchers went for longevity because they send signals to the body that things are good, that things are strong to build, to get stronger. We know people get older, they get weaker, they can’t function, and now it seems like all we’re hearing is that anything that tells the body that things are okay is not good for longevity and all these pathways that tell the body that we’re lacking, that we don’t have enough is where we need to go, but somehow, I think there’s got to be a balance.

Dr. Shade:           Yeah. It’s a balance of the two. There is no doubt at all that hormones are increasing your health span, if not, your total longevity. I mean, that’s just to say that they will wipe the slate clean. Most of these things that helping longevity are hermetic, and there are little stressors and you respond and clean it. You can overlay those on top of the hormone signals, and they’re not going to cancel each other out. Doing both is where you want to go.

Dr. Weitz:            Let’s consider that Fahy, which we mentioned, publishes the first study to improve biological aging, and he used DHEA and growth hormone in his-

Dr. Shade:           Oh, yeah. No, absolutely. Growth hormone is absolutely correlated with decay. There’s so many guys who do test in growth hormone and it’s like, “God! I feel freaking great,” and that is regenerative. So these other things are cleaning up. So you come in, you have a little Nrf2 activity, and you have some AMPK activity, some sirtuin. That’s taking out the trash, but the power is coming through the HP everything system.

Dr. Weitz:            Great. Another awesome discussion, Chris.

Dr. Shade:           Yeah. It’s been a great one.

Dr. Weitz:            Yeah. Yeah. I’ve really enjoyed this. I think we hit a lot of interesting science.

Dr. Shade:           Yep. All right.

Dr. Weitz:            Okay. Well, thank you, and I’ll talk to you soon.

Dr. Shade:           Thank you. Take care, Ben.

 



 

Dr. Weitz:            Thank you for making it all the way through this episode of the Rational Wellness podcast, and if you enjoyed this podcast, please go to Apple podcasts and give us a five-star ratings and review, that way more people will be able to find this Rational Wellness podcast when they’re searching for health podcasts.  I wanted to let everybody know that I do now have a few openings for new nutritional consultations for patients at my Santa Monica Weitz Sports Chiropractic and Nutrition Clinic. So if you’re interested, please call my office, 310-395-3111 and sign up for one of the few remaining slots for a comprehensive nutritional consultation with Dr. Ben Weitz. Thank you and see you next week.

 

Danielle Valoras discusses Breast Implant Illness with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

1:40  Brief history of Silicon Gel Implants (from the FDA website). 

  • Silicone breast implants were introduced in the US in 1962.
  • In 1976 the US Congress passed the Medical Device Amendments to the Federal Food, Drug, and Cosmetics Act.
  • In the early 1980s concerns arose about the safety of breast implants, esp. silicone gel implants and the FDA published case reports identifying frequent local complications and adverse outcomes and they identified possible cancer and connective tissue disease in some women with breast implants.
  • In 1992 the FDA removed all silicone gel-filled breast implants from the market due to safety concerns.
  • In 1999, the Institute of Medicine released a report that concluded that while there were lots of local complications and health concerns related to silicone breast implants, like rupture, pain, capsular contraction, and infection, that there was no evidence of systemic health effects such as cancer or autoimmune disease.
  • In 2006 the FDA approved silicone breast implants, specifically Allergans and Mentors based on 3-4 year safety reports from the manufacturers, but the FDA also required the manufacturers to conduct 6 post-approval studies for a loner period of time.
  • In October 2021 the FDA ordered stronger warnings for breast implants, including a boxed warning in which the risks are reported on the package.  Some of the risks that the FDA highlighted in the report include capsular contracture, implant rupture, and possible silicone gel migration into surrounding tissues, systemic breast implant illness with symptoms that may include fatigue, memory loss, rash, brain fog, and joint pain, and breast implant-associated anaplastic large cell lymphoma, abbreviated BIA ALCL.

8:21  Danielle’s personal story is that at age 48 she looked at the research and she chose to get silicone breast implants.  Danielle already had an autoimmune disease–Grave’s hyperthyroid and anyone with autoimmune disease should be careful with implantable devices like breast implants. After the implants, Danielle had hair loss, connective tissue issues, she tore both menisci in both of her knees and she had swelling in her ankles.  Her symptoms kept getting worse.  She had both breast implants removed, including the capsules and she got about 70% better right away.  Removing the capsule can be very difficult because the plants are under the pec muscles and the capsule is up against the back wall of the rib cage and scraping them off the back wall risks puncturing the lungs and causing a pneumothorax.  But Danielle feels that it is very important to remove the capsule as well as the rest of the implant, esp. since the capsule also contains silicone.  Both the silicone and the platinum that is used in the implant are quite dangerous.  Danielle discovered that she had very high arsenic levels and her arsenic levels came down after the implants were removed.

14:25  The capsule is the catcher’s mitt.  It is the scar tissue that forms around the silicone breast implant. Not only is silicone potentially toxic to the body, but there is also platinum used to make the silicone more gel like and to hold it’s shape and be more solid.  We know that the silicone and the palatium can get through the capsule and into the body.  The outer shell of the implant and even the outer shell of saline implants is made of silicone, so silicone comes into contact with the body.

18:37  Some of the silicone doesn’t crosslink and some it comes off the shell and into our bodies and it disrupts our methylation system, our hormones, and causes an inflammation cascade. It can reduce your ability to detoxify.

20:23  Breast implants eventually will leak silicone and those who have implants are told that they will eventually need to be replaced.  But it is the shell that sheds and biodegrades and leaks into the body. Dr. Edward Fleury from Brazil is a radiologist who has studied silicone induced granulomas that can form within the breast implant capsule. This leads to either a B or T cell response and this can lead to autoimmune disease and it can eventually lead to cancer. The T cell response can result in BIA-ALCL, which is Breast Implant Associated Anaplastic Large Cell Lymphoma.

 

 



Danielle Valoras is a Certified Physician Assistant and the Founder and clinician of NavWell Rx, PLLC, an integrative health practice.  Danielle is the originator of the Breast Implant Health Summit and she brings over 20 years of experience in medical research and education to her clients. She specializes in Psycho-Neuro-Endocrine-Immunology, a burgeoning field that investigates the link between the nervous system, the endocrine system, and the immune system in relation to physical health. Danielle’s practice integrates western medicine, functional medicine, trauma response and clinical bodywork therapies. She treats autoimmune issues, CFS/ME, and implantable device-related illnesses such as Breast Implant Illness (BII).  

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss and also athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111. Dr. Weitz is also available for video or phone consultations.



 

Podcast Transcript

Dr. Weitz:            Hey, this is Dr. Ben Weitz, host of the Rational Wellness podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to The Rational Wellness podcast for weekly updates, and to learn more, check out my website, drweitz.com. Thanks for joining me, and let’s jump into the podcast.

Hello, Rational Wellness podcasters. I’m very excited to be talking about a new topic for Rational Wellness, which is breast implant illness. Now, for those of us like me, who are not really familiar with this topic, I decided to look a little bit into the history of breast implant illness. Does it even exist, and what do we know about it? So I decided to take a very conservative route. So pretty much everything I’m going to say now is coming from the FDA.

Now, to be objective, a lot of people feel that the FDA is a bit too chummy with the medical device industry given the fact that a number of members of the FDA have come from this industry and big pharma and have gone back to work in industry after being at the FDA. So just so you know that everything I’m saying now is coming directly from the FDA. So none of this should not be considered as controversial.

So silicone gel breast implants were first introduced in the United States in 1962. In 1976, the US Congress passed the 1976 medical device amendments to the Federal Food, Drug, and Cosmetics Act. Breast implants were considered moderate risk class two. Then in the early 1980s, concerns arose about the safety of breast implants, especially silicone gel implants, and the FDA identified frequent local complications and adverse outcomes and published case reports identifying possible cancer and connective tissue disease in some women with breast implants.  At that point, the FDA reclassified breast implants into class three high risk products needing pre-market approval and called the manufacturers to provide data demonstrating safety.  In 1992, the FDA removed all silicone gel-filled breast implants from the market due to safety concerns. In 1999, the Institute of Medicine released a report that concluded that while there were lots of local complications and health concerns related to silicone breast implants like rupture, pain, capsular contraction, infection, that there was no evidence of systemic health effects such as cancer or autoimmune disease.

So in 2006, the FDA approved silicone breast implant, specifically Allergans and Mentors based on three to four-year safety reports from the manufacturers, but the FDA also required the manufacturers to conduct six post-approval studies, which would take a longer period of time. In other words, the breast implants are approved, but because there’s a risk, they want the manufacturers to conduct these post-approval longer term studies for safety.  Recently, last October of 2021, the FDA ordered stronger warnings for breast implants, including a boxed warning in which the risks were listed on the packaging. Of course, how many women actually see the packaging on their breast implants? Some of the risks that the FDA highlighted in the report include capsular contracture, implant rupture, and possible silicone gel migration into surrounding tissues, systemic breast implant illness with symptoms that may include fatigue, memory loss, rash, brain fog, and joint pain, and breast implant-associated anaplastic large cell lymphoma, abbreviated BIA ALCL.

Interesting, we have the FDA at one point in time saying there’s absolutely no risk of cancer, and now we have a cancer that’s absolutely tied with breast implants. So it just goes to show you how science changes and evolves with changing evidence. So anybody who comes on TV who says, “This is what the science is. This is what the truth is,” needs to be humble and realize that’s based on what evidence is currently available and that evidence could change.

Danielle Valoras is with us today, and she’s a certified physician assistant, and the founder of NavWell Rx PLLC, an integrative health practice. Danielle is the originator of the Breast Implant Health Summit, and she brings over 20 years of experience in medical research and education to her clients. She specializes in psychoneuroendocrine immunology, which is a burgeoning field that investigates the link between the nervous system, the endocrine system, and immune system in relation to physical health, and since we talk a lot about gut health and we talk about the gut-brain-immune connection, this is actually not something that’s unusual for our listeners.  Danielle’s practice integrates Western medicine, functional medicine, trauma response, and clinical body work therapies. She treats autoimmune diseases, chronic fatigue, and implantable device-related illness such as breast implant illness.  Danielle, thank you so much for joining us today.

Danielle:              Thank you, Dr. Weitz. It’s a pleasure to join you, and I’ve listened to you for so long that I feel like my education came from here. So I appreciate you very much.

Dr. Weitz:            Okay. Well, I thank you for that. So we were talking off air a little bit and you said you’re working with the FDA. Can you tell us a little bit about that? Maybe can you comment about the introduction I just gave because you are much more of an expert at this than I am?

Danielle:              Yeah. I would say I am in communication with the FDA versus working with them.

Dr. Weitz:            Oh, okay.

Danielle:              Just for clarity.

Dr. Weitz:            Helping to supply them with some information.

Danielle:              Yeah, and hoping to move the dial further with different not disciplinary actions, but the black box warning or fully informed consenting and that type of partnership. There’s not just me, but a group of women behind this movement. As you can see, since actually 2018-2019, we’ve actually made some pretty significant strides, and we hope to have more in the next three to five years as well.  My background as a PA since ’99 is one thing, but I’ve also worked in the medical device industry as a field clinical engineer for class three medical devices. So my world merged and I look at the clinical study and the clinical evidence that we don’t really have for the breast implants, and it just pushes me forward to do more.

Dr. Weitz:            So perhaps you can tell us about your personal story related to breast implants.

Danielle:              Yeah. My personal story is I was 48. I lost 40 pounds. I was in the best shape of my life, and I saw myself in the mirror and I thought, “If there’s ever a time to get breast implants, now would be the time,” and so I did. I mean, I did some research. I looked at the FDA approval. There were no warnings. I looked at the 2006 SSED, which is the Summary of Safety and Effectiveness Data that goes along with it. This was part of what I had done for my full-time day job as a class three field clinical engineer for cardiology. So I thought I had it all together.  Then I chose a physician, a plastic surgeon to put them in. I put them in and literally, for me, it was like three to four months later, things just started to happen, and it correlated with the time I was studying functional medicine, and timeline and history is everything, and it pretty much-

Dr. Weitz:            By the way, did you get to see the label on a box?

Danielle:              No. That was before the label existed, but what did exist, so I have a thyroid disorder called Grave’s disease that’s been treated. So anyone with … Say?

Dr. Weitz:            Hyperthyroid.

Danielle:              Yes. So anyone with an autoimmune condition should be very careful with implantable devices, especially breast implants or even asthma, right? That’s in the labeling in very small italicized print on the manufacturer’s website, but you don’t know which implant you’re going to receive. It may be one company over another.  So that was never brought up in my informed consent. In theory, I should never have been implanted because of the autoimmune issue that I had, and I was.  Looking back, from hair loss to connective tissue issues, I tore both meniscus in each knee and swelling and the ankles.  I should send you pictures so you can see, and the hair loss, and the fatigue, and the acne.  It looked like autoimmune issues, but my antibodies at the time actually were normal, at least the ones we were measuring for.

Dr. Weitz:            Now, when you say you shouldn’t have had the implants because of autoimmune disease, does the FDA currently recognize that breast implants may cause autoimmune disease or exacerbate autoimmune disease?

Danielle:              I would say that they say autoimmune disease or history of is a risk factor, and breast implants should not be placed in that population.

Dr. Weitz:            Okay. So they’re recognizing that there’s a relationship with autoimmune disease.

Danielle:              Yeah. A correlation might be a more politically correct word. Well, I mean, I don’t want to necessarily speak for the FDA, but there is and they made the manufacturers list that on their websites as well. Actually, relatively recently, they now have to go through a pretty decent informed consent for everyone who will get breast implants, and if they fail to do so, then it’s against regulation and, hopefully, folks would be held accountable for that, but yeah. That’s a mouthful.

Dr. Weitz:            So can you comment about why breast implants were taken off the market and then approved? Oh, wait. Go ahead and finish your story. Yeah, yeah. Are you finished with your story?

Danielle:              Basically. So at the end of the day, my symptoms just kept getting more and worse, and we thought it was physical, the weight of the implants, the brachial plexus right here, the lymphatic system, all of the above, and then I removed them, removed the capsule as well, and I’d say I got about 70% better right away in that was-

Dr. Weitz:            Is that a significant factor removing the capsule? Is that not always done?

Danielle:              It is not always done. In my experience, self-experience as well as with clients, when they remove all the capsule, there’s a greater or a less inflammatory response, especially if there’s silicone in the capsule.

Dr. Weitz:            Why would they not remove the whole thing? Why would they not remove the capsule?

Danielle:              Well, if you think about it, and I wish I had a model, for under the muscle, you’ve got the ribcage like this and you’ve got the pec minor, and then you’ve got pec major here. So they’ll cut the pec major to make place for this implant, whatever size it is. Usually, that pec major has to be cut, and that sits right on your ribcage. So you’ve got ribs, intercostal space, ribs, ribs, intercostal space, and what’s right behind there are the lungs or maybe even pericardium, depending on which way they are displaced near the sternum.  So to scrape that off the back wall risks a pneumothorax, risks puncture, and it could be dangerous, especially if the plastic surgeon is not versed into getting the capsule off, right? There are plenty of experienced explanters out there that can do the whole thing.

I know we’re digressing a little bit, but this brings up a great opportunity to talk about the capsule, which is the scar tissue, which is the catcher’s mitt for whatever is in the device, in this case, a breast implant or whatever’s in the shell and whatever comes out of that from off gassing to silicone, to platinum, to whatever’s in that catcher’s mitt. That catcher’s mitt gets formed, and sometimes we don’t make a very good catcher’s mitt. There’s that theory, and then sometimes we make what they call a baker stage four, which is very, very thick and a robust catcher’s mitt, right?  So there’s so much in that surgery to remove it, and sometimes it can actually get up to the brachial plexus and way up to the collar bone. So there’s some delicacy in there, but that tissue being the catcher’s mitt, to remove that I feel is imperative because it is the catcher’s mitt.  Right now, all I know to do is focus on silicone, silicone and platinum, because I know that it can get through the capsule into the body. There’s enough literature on that to support that, but there are beliefs that maybe that’s not advantageous to remove for the person, but I do think that it’s important, and that’ll be an arm wrestle for the next three to five years.

Dr. Weitz:            Is it better not to have the implant under the muscle? Can it be over the muscle?

Danielle:              It can be over the muscle, and the capsule that forms is still a catcher’s mitt, and you’re still you’re still right here in a very innervated and lymphatic-rich area that you still have the consequences, but you don’t have the cut pec major, right?

 



Dr. Weitz:            I’ve really been enjoying this discussion, but I’d like to take a minute to tell you about a new product that I’m very excited about. I’d like to tell you about a new wearable called the Apollo. This is a device that can be worn on the wrist or the ankle, and it uses vibrations to stimulate your parasympathetic nervous system. This device has amazing benefits in terms of getting you out of that stressed out sympathetic nervous system and stimulating the parasympathetic nervous system. It has a number of different functions, especially helping you to relax, to focus, to concentrate, get into a deeper meditative state, even to help you sleep, and there’s even a mode to help you wake up. This all occurs through the scientific use of subtle vibrations.

                                For those of you who might be interested in getting the Apollo for yourself to help you reset your nervous system, go to apolloneuro.com and use the affiliate code, Weitz10. That’s my last name, WEITZ10. Now, back to the discussion.

 



 

Dr. Weitz:            I heard you say in another interview that you ended up having very high arsenic levels and somehow this catcher’s mitt capsule affects why you had these high arsenic levels.

Danielle:              No. This is just a theory of mine. The implant definitely has metals, right? I mean, it’s listed, but the-

Dr. Weitz:            Right. Platinum is very common, right? Platinum is used in the-

Danielle:              In the crosslinking. Oh, yeah.

Dr. Weitz:            Why is platinum put in?

Danielle:              Because it makes the silicone more solid. It makes it more gel-like. It makes the shell, right? Oh, there’s so much to say. So there’s-

Dr. Weitz:            Right. It’s like making your paint, put the lead in the paint to give it real good textures.

Danielle:              Yeah. Yeah. Oh, I didn’t even go there, but absolutely. So you do this and some of the silicone doesn’t crosslink and you never have a perfect crosslink. So maybe instead of this, I feel like I’m doing an example of leaky gut right now, but instead of this, you actually get something like this, right? Then what comes off the shell is silicone, and plus or minus platinum, right?  So for me, I think the implants cause is our methylation system to disrupt, and I think that’s why I had high arsenic because as soon as it was removed, my arsenics went down. My arsenic level went down, right? Within two weeks, it was normal, but before, it was quite high. So I-

Dr. Weitz:            So your body’s detoxification capabilities to remove the normal amount of arsenic that unfortunately is contained in our food wasn’t filtered out.

Danielle:              That’s my belief. It just happened so fast that if it was something that was stuck in my system, it would’ve been deposited, and it was the fastest chelation if it was just from the breast implants, I think, but I do think it’s an endocrine disruptor, a methylation disruptor, and an inflammation cascade, right?  So depending, and I don’t even know that it depends on your genetics. I mean, it does. There’s some risk factors there, but I think that this is enough of a toxic load, especially over time for some that it will cause expression of the different genetics that we have.

Dr. Weitz:            We know that the silicone is eventually going to leak, right? Isn’t it the case that virtually every woman, if they have the breast implants for a long enough period of time, they’re going to have leakage, right?

Danielle:              Well, if I can, let’s back up just a minute because the shell is silicone of saline implants, of silicone implants.

Dr. Weitz:            Okay. So if you don’t get the shell out, you automatically have silicone that’s coming into contact with your other tissues.

Danielle:              Well, the shell of the implant and then the capsule, for sure. So every implant out there is made of silicone and people think, “Oh, I have saline.” It’s made of silicone, the outer lane.

Dr. Weitz:            So you’re saying the saline breast implants have a silicone on the outside.

Danielle:              Yes, a silicone-platinum crosslinking to hold everything together and in.

Dr. Weitz:            Oh, wow!

Danielle:              We’re finding evidence that it’s the shell that sheds. It’s the shell that biodegrades. It’s the shell that is the initial insult.

Dr. Weitz:            Okay. So even forgetting about leakage of the silicone gel, the shell is shedding silicone into your body.

Danielle:              Yes, and there’s something that Dr. Eduardo Fleury from São Paulo, Brazil, he’s a radiologist, MD, PhD, and he studies silicone-induced granulomas within the breast implant capsule. So whether it’s saline or silicone, you can see the silicone granuloma. So look up his research. It’s really wonderful.

Dr. Weitz:            What is a silicone granuloma?

Danielle:              It is basically silicone that’s gotten out of the shell of the implant and your body’s responding to it and your body is wonderful, right? So it attacks it, and-

Dr. Weitz:            The immune system response.

Danielle:              Yes, and I think specifically for most, it’s a T cell response. There are some B cell response to the breast implant that causes a different type of cancer, but T cell is BII, which is breast implant illness, and T cell response is BIA-ALCL, which is the lymphoma caused specifically by the breast implant. So it’s a granuloma, the immune responses. The immune makes a response and there’s attack to it. Then you’re dealing with this inflammatory cascade from the get-go.  Now, you have a catcher’s mitt, which is the capsule that your body formed around it, which three to four months, you should have some scar tissue in place, but also, when you have that inflammation, biofilm forms, and that changes your normal flora, and there’s a whole other podcast we can do on that, but it causes a cascade that the body has to handle, and can your body handle that inflammatory response? Does it have enough?  Chronically over time, toxicity in my world breeds deficiency, and sure, we can replace the deficiency or we can try, but it’s always going to be a load. It’s always going to be a load. If that was our only load other than glyphosate, other than all the leaky gut and the different things, maybe we would be able to handle it better, but-

Dr. Weitz:            Do we have a good test for silicone?

Danielle:              We do not. The best test is an MRI. It’s a breast MRI with or without contrast. I would say with contrast gives you the higher yield to see if you have that silicone-induced granuloma. It’s not quite for silicone, but we have blood tests that you can look for silicone, but the molecules in which they’re testing for isn’t necessarily the breast implant.  Now, if you have a frank rupture, maybe this would capture that. We do have silicone sensitivity tests that we can do, but in my patient population, I’ve never seen anyone positive with the sensitivities for silicone. For other things that are in the breast implants like when you do the environmental toxins and stuff, you can see those all high, but silicone never registers for these people, and they are very sick.

Dr. Weitz:            What about urine? Same?

Danielle:              Same, same, right. You can test. We see people doing a lot of heavy metal testing. Those will be disrupted because I think of the methylation more than what is in. What is in the implants causes this cascade of disruption. I don’t know that what you’re measuring is because of the breast implant like mercury is for fillings. So there are tests that I use to help get methylation in the Krebs cycle, really, in the mitochondria are more robust and that’s an organic acid test for me. I tend to use Great Plains because they show the oxalates. Vibrant Health also shows oxalates.  What I find actually is that we are more deficient, significantly deficient in B6 and B1, and adding those over the folate and the B12, move the dial more better, different while you are opening up the drainage pathways. That’s key. Get things moving.

Dr. Weitz:            Now, you’re talking about treatment for patients with breast implant illness.

Danielle:              Yeah. Yeah. I think there might be a little bit more to say about the capsule, making sure the capsule’s removed and then the silicone granuloma. So testing for illness, Dr. Tervaert-

Dr. Weitz:            Now, let’s continue to talk about how breast implants cause illness. How do breast implants lead to autoimmune disease? What is the immune system reacting to that’s causing cross-reactivity?

Danielle:              That’s a great question, and if I knew that specifically, it would be or I could retire, but what I know is that there is reaction-

Dr. Weitz:            Calling Dr. Vojdani, we need your help.

Danielle:              Yup. Silicone and platinum seem to be the biggest foes and the two components of the breast implants that we know cause a certain cascade, right? So the cross-reactivity, I don’t know. I’m sure there’s more and I hope he does call.

Dr. Weitz:            No. We do know that breast implants cause cancer, this specific form of cancer, anaplastic large cell lymphoma.

Danielle:              Yeah, and that’s a T cell cascade, specifically to the silicone. What you’ll find interesting in the literature by Fleury and Susan Turner is if you look at their work and you extrapolate the T cell, what you’ll see in Fleury’s work is he finds the silicone-induced granuloma before BIA, BIA-ALCL, before the lymphoma, and also before the BII, right? So what we don’t know is what causes the T cells to proliferate to make lymphoma and what causes the T cells to stay in a certain way for BII, right?  Now, they’re going to say that the literature is based on textured implants for the lymphoma, but you see the same granuloma and on MRI before, and with BIA-ALCL and BII.

Dr. Weitz:            When you say BII, for everybody, she’s talking about breast implant illness versus the breast implant associated cancer.

Danielle:              Lymphoma, and let’s be specific. That’s just one of them associated with the textured implants, but there’s sarcomas, melanomas. There’s many other cancers that are linked to the breast implant.

Dr. Weitz:            What are some of the other common cancers that are linked with breast implants?

Danielle:              Melanoma and sarcoma.

Dr. Weitz:            Okay. Sarcoma of bones or soft tissues or what?

Danielle:              You see the granuloma and the biopsy shows that it’s a sarcoma-related tissue. That’s in the literature, for me, right? It’s within the breast implant capsule and you can see … Oh, so remember how we were talking about the shell?

Dr. Weitz:            Right.

Danielle:              So once you have these openings, things can get out as well as in. So I think that’s where the irritation and the granulomas begin, and how it deforms I don’t know.

Dr. Weitz:            Okay. Okay. So go ahead. So sarcomas, and what other kinds of cancer?

Danielle:              I’ve read on melanoma. My patients haven’t had the sarcoma or melanoma.

Dr. Weitz:            Okay. I heard you talk about some of the gastrointestinal symptoms related to breast implant illness and how this can be a cause of leaky gut. I personally treat a lot of patients with IBS and SIBO and leaky gut. I wonder if this could be one of the reasons we don’t consider for patients who don’t improve as much as we had hoped.

Danielle:              If anyone has an implantable device and they have GI issues that we try and we try, I think we need to dig further. The question should be for every patient, “Do you have an implantable device?” Some people don’t consider IUDs as an implantable device, right? Some patients don’t remember they have a dental implant or they’ve ever had a root canal or things like that, but they definitely are inflammatory, and if that person doesn’t have enough reserve to handle inflammation, total inflammation, it’s hard to move the dial.

Dr. Weitz:            So, unfortunately, though, it sounds like from what I’ve heard and read so far that if somebody like me is working with a patient with gut problems and we suspect that there might be a breast implant related factor, there’s not one definitive test I can do to say, “Yes, we know your breast implant is part of the problem.”

Danielle:              Correct, but I think as practitioners we should be knowing what is in the person’s body, in their history, right?

Dr. Weitz:            Yeah, no, I mean, we’ll have to decipher from history and suspect that possibility.

Danielle:              There’s something called the Bradford Hill criteria, and there’s a Dr. Jan Tervaert out of Canada who just published a paper on how he diagnoses breast implant illness and the evidence for it. If someone comes to me with breast implants or they just come to me because they’re tired and we take a full history, I now for the past four years have been asking, “Do you have an implantable device? Do you have breast implants? Do you have a penal implant? Do you have dental implants? Let’s go down the list. Do you have a pacemaker? Do you have a fake hip, fake knees?” We’d go through it all. There’s some of those that are things you can do about, and there’s some that like a pacemaker would be really hard to remove, right?  So at least we know that if you have a mesh, oh, that’s a whole other conversation, that inflammatory cascade is very similar to breast implant cascade as well. If we’re going for the low hanging fruit at first, we’re going to decrease inflammation, oxidative stress, all of that, and work with the gut, right?

Dr. Weitz:            So you find that these meshes, which are, say, for example, common in hernia surgeries and some of these other surgeries where-

Danielle:              Pelvic.

Dr. Weitz:            Pelvic surgeries, yeah.

Danielle:              Yeah. They also can cause, well, let’s just call it an inflammatory cascade for now, and it’s so embedded in the tissue just like some of the breast implants and the capsules are embedded into the tissue, and the granulomas that occur with them are of concern, right? Some of these procedures are elective. So we are now putting devices in people that cause inflammation, and our first job is to do no harm. So yeah, my brain just went in five different directions on what else do I want to say about meshes, but meshes can cause the same issues, for sure.

Dr. Weitz:            Meshes don’t have Silicon, right? They’re just made from plastic of some type.

Danielle:              They are made of … What are they made of?

Dr. Weitz:            Polycarbonate or something like that, I believe, some of them.

Danielle:              Yeah, and I think they’re-

Dr. Weitz:            I mean, I had one put in for a hernia in 2000.

Danielle:              What are your symptom? No, just kidding. No, but if you can, again, toxicity breeds deficiency. So I have women who come to me who have all the signs and symptoms and even have SIGBIC on MRI, and they’re not ready to remove them. They may never be ready to remove them.

Dr. Weitz:            SIGBIC is silicone-induced granuloma breast implant capsule.

Danielle:              Yes. So sorry.

Dr. Weitz:            That’s okay.

Danielle:              They want to keep them. “Okay. So let’s empower you. Let’s be totally informed, and let’s see what we can do to help you have vitality in life,” right?

Dr. Weitz:            So let’s go over how you could treat from a functional medicine or integrative perspective a patient who comes to you with some illness related to breast implants or even other implants.

Danielle:              Yeah. Number one is ask what they have inside their body, right? We ask them the supplements. Some of the women who come I can’t tell that they have implants, but they’ve had them in for 20 years, right? So if they’ve had a breast implant set or second set in for 20 years or over seven to 10, we’re having the conversation that they don’t last a lifetime, and there’s something to be considered for changing them out or at least getting imaging to see if they’re ruptured, right? So I start there.  So then if they get the imaging and they don’t have SIGBIC, let’s say their implants have been in for three years but they’re still feeling crummy and they don’t have SIGBIC, then it’s an informed conversation of we don’t see the granuloma yet. By the time we see the granuloma, we know that silicone is outside of the implant, into the capsule, and potentially has migrated through the body. Then as we know, your body may or may not create antibodies to this and you don’t know where this cascade of silicone will land, right? Then we’ll take another MRI in a year or in two years and we’ll follow it that way.

Now, if they have SIGBIC, the conversation is, “You have inflammation in your body. The breast implant is leaking. We know this because of the SIGBIC, and now what do you want to do about it? Do you want to go for explant? How do you want to have vitality?” So we’ll do an organic acid test. We’ll sometimes do a DUTCH test and a stool test and see what we’re dealing with. We’ll do the Lyme and the EBV.

Dr. Weitz:            Okay. What sorts of things might you find on those tests and what will that tell you, and then what do you do about it?

Danielle:              Oh, you see a toxic load usually, and you’ll see methylation issues. If anyone doesn’t see a low B6, I would like to see that because I haven’t seen that yet. You’ll see low B6. You’ll probably see oxalates. You’ll definitely see candida. You’ll see, going down the list, plus or minus. A lot of these people-

Dr. Weitz:            Why would you see candida?

Danielle:              For me, I think people want me to say metals, but the methylation disruption and the inflammation, now, it’s a very overwhelmed body. It’s a great environment for it to grow. Now, this is organic acid, right? So this is in the urine even. Sometimes you see mold. You see mycotoxins for some of them. I see that a lot with specifically saline. I’m going down the organic acid test.

Dr. Weitz:            Why do we get mycotoxins with saline breast implants?

Danielle:              Yeah. That’s a great question because it’s not necessarily, “Is it being introduced? Is it inside? Is it introduced during the surgery? Is it inside the implant? Is it in the body?” We don’t know it. In some places it grows. I don’t have the answer. I wish I did, but I don’t, but you do see it, right? Sometimes maybe that’s where it lands because they’ve had mold exposure before, right? Some of these women have been exposed to Lyme. There are co-infections, and a lot of people have EBV or mono, and that gets reactivated, right? So a lot of the functional med.

In the beginning, I was just treating that and treating that and not considering the implantable device, and didn’t really make much headway with that. Oh, there’s so much to say. The people who I see have mold and have that sensitivity like a mast cell, a histamine response, they can’t eat too much, they can’t take supplements, their nervous system is just off the charts, those are the tough ones. I need more practitioners to share are their stories how they help these patients. I don’t see those patients being able to not explant.

 



Dr. Weitz:                            I’d like to interrupt this fascinating discussion we’re having for another few minutes to tell you about another really exciting product that has changed my life and the life of my family, especially as it pertains to getting good quality sleep. It’s something called the chiliPAD, C-H-I-L-I-P-A-D. It can be found at the website chilisleep.com, which is C-H-I-L-I-S-L-E-E-P dot com.

So, this product involves a water-cooled mattress pad that goes underneath your sheets and helps you maintain a constant temperature at night. If you’ve ever gotten woken up because temperature has changed, typically gets warmer, this product will maintain your body at a very even temperature, and it tends to promote uninterrupted quality deep and REM sleep, which is super important for healing and for overall health.

If you go to chilisleep.com and you use the affiliate code, Weitz20, that’s my last name, W-E-I-T-Z, 20. You’ll get 20% off a chiliPAD. So, check it out and let’s get back to this discussion.



 

Dr. Weitz:            Is there a way to detox silicone or some of the other things associated with breast implants? Is there a silicone detox program?

Danielle:              Open up all the drainage pathways. Keep it moving. Heat.

Dr. Weitz:            How do you like to open up drainage pathways?

Danielle:              Lymphatic drainage massage. I use something also, to instruct the patients to use something like block therapy. So in my practice, I do osteopathic manipulation. So we’ll do visceral. We’ll keep that moving, flush the liver, and manually do that, do heat with sauna, make sure you’re able to sweat, breathwork, all the drainage pathways, breath, liver, kidneys, urine, feces.

Dr. Weitz:            Yeah. Some doctors talk about using herbal bitters to get bile flow. Some doctors talk about there’s this-

Danielle:              [inaudible 00:43:03]

Dr. Weitz:            Exactly.

Danielle:              It’s all of it. Most everyone under this chronic stress for some length of time have decreased HCL. There’s things like if they have edema, that HCL is going to really or some other kinds of enzymes that could really help that patient. Opening it up from the mouth to the stomach, to the liver, the bile duct. The gallbladder is usually a mess when you look at their organic acid, most of them, but I think this is true for many of our chronic, well, autoimmune patients is their amino acids are so low and either they’re not taking them in or they don’t have enough of what it takes to break it down, right? So you just start with the basics. Open it all up and that tends to help.

Dr. Weitz:            Okay. What else can we do to help patients with breast implant illness besides detox?

Danielle:              Yeah. So the nervous system and listen to the patient. Create a safe space for that patient because by the time they found a functional medicine practitioner, they’ve probably been to at least five to 10 others, right? They’ve been to the ER so many times. So just to listen and to create that safe space for them, I think that provides so much healing. Replace the deficiencies. I tend to start mitochondrial Krebs cycle first, and that seems to move the dial quite well.

Dr. Weitz:            What does that mean practically? Exactly which-

Danielle:              B6, B1. I don’t do B complexes because you need so much more than what that can offer, right? I mean, the magnesium, the electrolytes, these people are adrenal fatigues so you go that route as well. I’m assuming people who are listening know how to beef up their adrenals, take away the stress. Breathwork is amazing. The rest is the full functional medicine profile.

Initially, explant has proven to decrease the symptoms. For me, I call it nutrient-riching and opening up the drainage pathways. That moves the dial the most. You just had Todd Watts on not too long ago. When I added the Cell Core products to these women, we’re actually going to do a clinical study, a feasibility coming up, the carbon technology just shifted things to faster.

Now, the people that have very high sensitivities or mast cell got to go really slow, but following their opening up the drainage pathways, addressing viruses, addressing parasites and different things has really impacted the health of the BII population quite well.

I’d like to say I had it really good before, but I added this and it’s even better. So I’m going to start a HOPE clinical trial, and it’s called How to Optimize Post Explant. We’ll be doing 20 women. It will start in 2022. I think we’ll be doing it at two plastic surgeons offices who explant so we can track everything that we know to track today and we’ll see the people who have not improved at the three month marker, they will see if they meet the inclusion/exclusion criteria, and those who have explanted before and end of a year.

So we’ll get this population that wasn’t all the way helped and they still have symptoms post-explant, and we’ll see if we can move the dial with what we’re talking about here and, hopefully, give other practitioners, “Okay. I’m going to do it this way,” at least a correlation if we can.

Dr. Weitz:            Okay, cool. So you said you would use some products from Cell Core that help to detox and clear out parasites and you found this really helpful.

Danielle:              Yeah, and even their phased approach, right. I think that it makes sense to open up the exit door before yelling, “Fire,” right? Otherwise, you think about that for estrogen, right? You give dim, dim, dim all day long, and you don’t have any amino acids and the different things, and you’re not going to have what you need to succeed in that. So doing the same approach I think will work in implantable devices for the women.  So the problem with silicone on the periodic table is that it’s right underneath carbon. So I think one of the things that Cell Core has is it’s carbon technology. So silicone will bind to a carbon site, and how do we release it? Well, the only way you can release it is to fold it. How do you fold it? Maybe heat it, change its oxidative state. We don’t know this information. I wish I could say, “Oh, take an inositol and that’ll do it,” but it doesn’t, right?  So you need to unbind it in many of the cases, and then you need to make sure carbon binds with that while you’re pushing the silicone along. So that’s why moving lymphatic, breathwork, exercise, sauna, you’re heating it, we’re doing everything we can to change our own oxidative state. I don’t know necessarily how to impact that bound silicone and change its oxidative state, but I can heat it with sauna. I can do some red light therapy. I can manipulate it, but there’s not full data on that. That’s just what I’ve clinically found that works.

Dr. Weitz:            Great.

Danielle:              It’s suffocating.

Dr. Weitz:            No, it’s great. A lot of stuff to think about, and it’s hopeful that we’re getting more information about some of the health effects of these silicone and saline breast implants, and that there are some strategies that are helping women with these and potentially similar problems with other people who have other sorts of implantable devices, including mesh.

Danielle:              Yeah. Yeah. That’s going to be interesting cascade, for sure.

Dr. Weitz:            Have you had hernia patients with-

Danielle:              Yeah. Yeah. More like fatigue and dampen symptoms. By the time breast implant, people have autoimmune. It’s been. We went through the whole autoimmune trajectory. I mean, you’re not diabetic today, but you weren’t yesterday, right? So there’s this behind here.

Dr. Weitz:            There’s this long, long, long pathway. Yeah.

Danielle:              I don’t know that mesh leaks like the shell of the implant. So I think it causes irritation and inflammation and depending on how you build the scar tissue, but it doesn’t have the same structure as a breast implant shell does. So while it does cause issues, I don’t know that it will impact. I think it would impact less, but we don’t know.

Dr. Weitz:            Then of course, we have an individual response. You have four people in a house with mold and one of them gets really sick and one of them gets mild symptoms and the other two never have any symptoms.

Danielle:              Yeah. One of the things we’re going to look at in the HOPE clinical study is we’ll do a full DNA panel and we’ll see if there’s, I mean, everyone talks about, “Oh, I’m MTHFR.” What about GST? What about all these other things? I think we’re going to find correlations there. So for people with mesh, I would look at the same thing and see, and then at the end of the day, all we have is choice to optimize, and there are some things like pacemakers and they had polyurethane leads and silicone leads and platinum tips or platinum iridium tips, right? So we’re not going to remove them, but how do you optimize that patient, but knowing what this can cause may help. Is it inflammatory? Is it oxidative? Is it that? That I think is Functional Medicine 102, right?

Dr. Weitz:            Great. So any final thoughts for our listeners and viewers as we wrap this up?

Danielle:              Yeah. If there are practitioners out there that see breast implant illness or related complications from PTs, functional medicine, we host every other year a breast implant health summit. This year will be October 20, 2022. I’m looking for more practitioners to speak what they do because it takes a collaborative team to, if we can heal these people more better, different, faster, that’s the goal. So if people would like to either have more information on the breast implant health summit or present at the breast implant health summit, then please connect to me through the breastimplanthealthsummit.com and that would be a great way to connect.

Dr. Weitz:            Excellent. Thank you, Danielle.

Danielle:              Thank you very much.

 


 

Dr. Weitz:            Thank you for making it all the way through this episode of the Rational Wellness podcast. If you enjoyed this podcast, please go to Apple podcasts and give us a five-star ratings and review. That way, more people will be able to find this Rational Wellness podcast when they’re searching for health podcasts.  I wanted to let everybody know that I do now have a few openings for new nutritional consultations for patients at my Santa Monica Weitz Sports Chiropractic and Nutrition Clinic. So if you’re interested, please call my office, 310-395-3111 and sign up for one of the few remaining slots for a comprehensive nutritional consultation with Dr. Ben Weitz. Thank you and see you next week.

 

Dr. Mona Morstein discusses An Integrative Approach to Diabetes at the March 24, 2022 Functional Medicine Discussion Group Meeting with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

8:28  95% of cases of diabetes are Type II and it is related to obesity, among other things. There are about 8 billion people on earth and about 2 million are overweight.  In the US, statistics on obesity are staggering, and even 15% of children are obese.  Over 37 million people in the US have diabetes and another 100 million have prediabetes, so one out of every three Americans have diabetes or prediabetes.  Close to 50% of those over age 65 have diabetes in the US.

11:02  TYPES OF DIABETES:  

1. Type I Diabetes, which is our classic Pediatric Autoimmune disease.  It typically does not start below one and half years and fades out around age 25.  There is an ongoing trial called the TEDDY trial, which stands for the Environmental Determinants of Diabetes in the Young, and they are looking at figuring out what the triggers are, including diet, nutrient deficiencies, vaccinations, infections, stress, etc..

2. Latent Autoimmune Diabetes of the Adult, LADA.  This condition tends to start after age 35 and most are in their 40s and 50s and they are insulin dependent.  Many of them get misdiagnosed with type II diabetes, since many physicians are not knowledgeable about LADA. This type I can be very slow onset where they may not need insulin at first, or they may just need a small amount of insulin, sometimes for decades, or they need full blown insulin from the start.

3. Type II Diabetes. This is the most common form of diabetes and it is insulin resistance driven. Most patients with Type II Diabetes are poorly controlled and many of these will go on to eventually need insulin.  But insulin dependent Type II Diabetes is still Type II.

4.  Mature Onset Diabetes of Youth, MODY.  This is related to genetic mutations where people either are unable to secrete insulin or are unable to receive insulin.  Athena Diagnostics offers testing to measure 1, 2, 3, 4, 5, and 8 of the MODY genes. For this group, sulfonylureas, which are not really good drugs for most of us, work really well for this group.

18:34  Complications of Type II Diabetes:  1. Hypertension, 2. Chronic Kidney Disease, 3. Impaired vision, 4. Neuropathy, 5. Amputation, 6. Pregnancy complications, and 7. NAFLD.  The majority of our cells have an insulin receptor and this allows them to grab glucose and pull it into the cell and turn it to fat and store it or burn it. But there are four cells in the body that don’t have insulin receptors, which are the eyes, the kidneys, the nerves, and the endothelial lining of the blood vessels.  When glucose gets into these cells, there is no insulin to process it, so if your blood sugar level is 300, then the sugar in your eyeballs will be 300. The cells in these tissues therefore become damaged if your diabetes is uncontrolled. If your diabetes is uncontrolled, you have a 4-6 times increased risk of dying from cardiovascular disease. Diabetes is the number one reason people wind up with end stage kidney disease. It’s the number one reason adults go blind. It’s the second most common reason for amputations and there are 356 diabetes amputation every day in the US. Diabetes can lead to non-alcoholic fatty liver disease.

22:05  Laboratory Analysis of Diabetes.  Labs should include CMP, CBC, lipids, Ferritin, which can help to detect anemia and it is an early indication of fatty liver. If there is indication of fatty liver, you do an ultrasound. GGT, which is another liver detox enzyme.  If someone is injecting insulin, then measuring insulin is no longer accurate. C-peptide is a better indication than insulin.  To assess heart disease risk, a standard lipid panel is bogus, so you need an advanced lipid profile and you need to include Lp(a), APoB, Oxidized LDL, Homocysteine, Fibrinogen, HsCRP.  You should check random micro-albuminuria at least once a year, which can show early kidney damage. The diabetic antibodies to diagnose LADA include GD65, insulin antibodies, Islet cell antibodies, Tyrosine phosphatase, and Zinc transporter 8. If it’s type I, then you also want to look at Celiac and thyroid antibodies.  Hemoglobin A1C. There is a .5 variability with this test.  In general, the lower the A1C  the better.  An A1C over 5.5 is already beginning to cause damage in the body such as to the eyes. [Association of A1C and fasting plasma glucose levels with diabetic retinopathy prevalence in the U.S. population: Implications for diabetes diagnostic thresholds]  Over 6 it’s causing kidney damage. [Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: Atherosclerosis Risk in Communities (ARIC) Study

30:00  A Hemoglobin A1C of 5 translated to an average blood glucose of 100, six is 126, seven is 152, etc. You can have two different patients both with a A1C of 6 but one patient can have good, steady control with only mild ups and downs and another patient could be at 50 for half a day and at 150 for the other half and that patient could also have a A1C of 6.

31:44  There are certain cases where the A1C is inaccurate, including with patients with genetic hemoglobinopathy, like sickle cell anemia, you can’t really use A1C, you’d have to use fructosamine, instead. The only problem with fructosamine is that it doesn’t translate to a glucose number.  If the patient has serious liver or kidney disease, the A1C will be inaccurate and will appear lower. It can be too low if they have serious bleeding or high if they have iron deficiency anemia.

32:36  There are a few studies, including the ACCORD trial where they had patients eat whatever they want and they lowered the A1C below 6.5 by using some very strong medications, including the sulfonylureas, which cause weight gain and water retention, the TZDs, which cause weight gain and water retention, and insulin, which causes weight gain and water retention, and they had more patients dying. They concluded that lowering the A1C below 6.5 is not a good idea because it will cause heart disease and this has led some doctors to recommend not trying to get the A1C below 6.5. But all the ACCORD trial showed is that lowering your A1C below 6.5 without dietary changes and only using very strong medications will increase your risk of heart disease.  If the patient is able to lower the A1C to 5.4 with diet, supplements, and Metformin, they are not going to have a high risk of cardiovascular disease.

34:25  The American Diabetes Association has set the following glucose goals for diabetic patients, but they should be more stringent:

1. A1C below 7

2. Fasting glucose 80-130 mg/dL

3. Post-prandial <180 mg/dL 

Dr. Morstein feels the following goals would be better guidelines:

1. A1C below 6.

2. Fasting glucose <110 mg/dL  Ideal <100 mg/dL

3. Post-prandial <120 mg/dL  Ideal <110 mg/dL 

 

34:50  Diabetic Medications:

1. Insulins:

       A. Basal:

             Long-Acting: Levimir/detemir, Lantus/Toujeo/Glargine/Basaglar, Tresiba/degludec 

             Intermediate-acting: NPH (Neutral Protamine Hagedorn)

      B. Bolus/Corrections:

             Short-acting: regular insulin 

             Rapid-acting: Novolog/aspart, Humalog/lispro, Apidra/Glulisine,

             Very-rapid: Fiasp/aspart

2. Oral Hypoglyemics: 

       A. Biguanides: Metformin HCL, and there is an extended release  

       B. Sulfonylureas, which are problematic drugs because they cause water retention and weight gain and there is a high risk of hypoglycemia:

             Glipizide

             Glyburide, which is the worst one for low blood sugar,

             Glimepiride, which is the best in this group

       C. Mitiglinides, which nobody uses 

       D. Thiazolinediones (TZDs)

             Rosiglirtaxzone (Avandia)

             Pioglitazone (Actos)

       E. Sodium Glucose Transporter 2 Inhibitors–these are not bad drugs, but the sugar can cause bladder infections or jock itch or vaginal infections

             Canagliflozin  (Invokana)

             Dapgliflozin (Farxiga) 

             Empagliflozin (Jardiance) 

             Ertugliflozin  (Steglatro)

       F. Dipeptidyl Peptidase 4 Inhibitors (DDP4 inhibitors)–these seem to be fairly safe, though they are fairly weak.  And at their highest dosage they have a lowering of the A1C of like 0.5, while just taking out grains from their diet will lower A1C by 3.3%.

             Januvia/sitagliptin 

             Tradjenta/linagliptin 

             Onglyza/saxagliptin 

             Nesina/alogliptin

       G. Glucagon Like Peptide-1 Agonist–These are really good drugs that are fairly effective, and they may help patients lose weight, they reduce their appetite, but they are quite expensive.  There may be some nausea as a side effect.

            Dulaglutide/Trulicity 

            Exenatide/Byetta 

            Exenatide ER/Bydureon 

            Livaglutide/Victoza 

            Lixisenatide/Adlyxin 

            Semiglutide/Ozembic/Rybelsus 

            Albiglutide/Tanzeum

38:30  With respect to Continuous Glucose Monitors, there is the Dexcom and the Freestyle Libre from Abbott and Dr. Morstein finds the Dexcom much more accurate than the Freestyle Libre.

39:50  Diet for Diabetes.  In 2013 or 2014 the American Diabetes Association acknowledged that low carb diets may have value for diabetics. If we look back 100 years ago, there were not that many type II diabetics and the type I diabetics were dying pretty awful deaths until we invented insulin. Then diabetic patients were able to live longer, but they all eventually died of cardiovascular disease, so it was thought that this meant that their fat was too high, so the whole country started preaching eating low fat. Everybody started eating more carbs and things went downhill from there.  Only in the last few years have the ADA turned around and endorsed a lower carb diet for type II diabetics.

41:42  For Prediabetes the PREDIMED study showed that the Mediterranean diet works well.  [Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet]  Compared to the low fat diet, the Mediterranean diet reduces diabetes by 52%, which was more beneficial than putting patients on Metformin.  However, the low carb diet performs better than the Mediterranean and leads to most lowering of the A1C.

42:48  There is an outlying diet known as the MA-PI2 Diet, which is the high carb, plant based diet for diabetes.

 

 

 



Dr. Mona Morstein is a Naturopathic Doctor who practices at Arizona Medical Solutions in Tempe, Arizona. Dr. Morstein: has a practice focus on treating patients with autoimmune diseases, hormonal conditions, diabetes, thyroid, and gastrointestinal disorders like SIBO and IBS.  She is the author of the best-selling book, Master Your Diabetes: A Comprehensive, Integrative Approach for Both Type I and Type II Diabetes and she lectures frequently at medical conferences.  Her website is azimsolutions.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss and also athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111. Dr. Weitz is also available for video or phone consultations.



 

Podcast Transcript

Dr. Weitz:                           Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. To learn more, check out my drweitz.com. Thanks for joining me and let’s jump into the podcast.

Welcome everyone to the functional medicine discussion group meeting tonight on integrative approach to diabetes care. We’re very happy to be joined by Dr. Mona Morstein. I’m Dr. Ben Weitz and I’d like to make some introductory remarks before making some remarks about our sponsor, and then I’ll introduce our speaker and we’ll get started. So I encourage each of you to participate and ask questions by typing in your questions in the chat box. Then I’ll either call on you or simply ask Dr. Morstein your question when it’s appropriate.

So I hope that you’ll consider attending some of our events in the future. April 28th, we have Dr. Paul Anderson speaking on an integrative approach to cancer. May 26th, Dr. Sarah Thompson will be speaking about a functional approach to maternity. Then the next meeting after that will be June 23rd and that’s yet to be determined. So if you are not aware, we have a closed Facebook page, the Functional Medicine Discussion Group of Santa Monica, that you should join so we can continue the conversation when this evening is over.  I’m recording this event and I will include it in my weekly Rational Wellness Podcast, which you can subscribe to on Apple Podcast, Spotify or YouTube. If you do already list into the Rational Wellness Podcast, I’d very much appreciate it if you could go to Apple Podcast and give me a positive ratings and review.

 

So now I’m very happy to tell you about this evening’s sponsor, which is Integrative Therapeutics. I’d like to take a few minutes to tell you about a few of their products. One of their most popular products is Cortisol Manager, which is an excellent combination of several adaptogenic herbs and phosphatidylserine, which helps to modulate cortisol levels, which can be helpful in modulating blood sugar levels since cortisol surges due to stress can cause blood glucose levels to rise, which I’m sure Dr. Morstein will mention.

Another excellent product in the Integrative line is Berberine, which has quite a bit of research to back up its benefits in helping to control blood sugar and to improve insulin sensitivity. In fact, some studies show that it is equally as effective as Metformin, and can also be used concurrently with Metformin and has been shown to improve Metformin’s efficacy. This Integrative Berberine product is Berberine HCL, which is not an extract of Berberine from Berberine containing herbs, which is in their Berberine complex which is better for use as an antimicrobial for gut health.  In other words, if you’re using Berberine for managing blood sugar or helping with lipids, then you want to use the Berberine HCL. I personally use Integrative’s Berberine product for my patients because of its quality, both for blood sugar management, for control of lipids, and also as a longevity agent since it’s an activator of AMPK. One of the reasons why he Integrative’s Berberine and their other products are such high quality is because the company uses a manufacturing facility that’s a drug GMP facility rather than a dietary supplements GMP, which means that they test every line. They do bio-validity testing, stability testing for up to two years past the manufacturing date, et cetera.

So Dr. Mona Morstein is a naturopathic doctor in Tempe, Arizona who’s a practicing functional medicine doctor at Arizona Integrative Medical Solutions, which has a focus and her practice has a focus on treating patients with autoimmune diseases, hormonal conditions, diabetes, thyroid and gastrointestinal disorders like SIBO and IBS. She’s the author of the bestselling book, Master Your Diabetes: A Comprehensive, Integrative Approach for Both Type 1 and Type 2 Diabetes. I got to tell you, this is one of the most impressive, comprehensive, useful books that you would ever want to have and everybody should have this on your shelf for help with managing patients with diabetes. Dr. Morstein, thank you so much for joining us. You have the floor.

Dr. Morstein:                     Thanks very much, Ben. I really appreciate the intro and I hope everybody can see the lecture, the slides okay. I wrote kind of as a joke an abbreviated diabetes lecture, because it still is like 70 slides. but I try to extract. I’ve taught a lot of diabetes webinars to physicians and it’s usually a kind of a weekend affair, all day Saturday and all day Sunday. So we’ll try to touch upon a lot of things right now today. I also know I’m speaking to physicians, so you’re already coming with a fairly high level of comprehensive knowledge of this condition.

Okay. He just mentioned me. This is me. I will say this, I don’t think we talked talk about this enough in medicine because it’s embarrassing, but I got into diabetes because literally way, way back when, I mean 30 years ago, I missed the I missed a diagnosis of a type 2 patient in kind of an acute crisis of diabetes. So that really shook me to the core. I was a new doc, just starting out in Montana, and it made me doubt if I was a safe, responsible physician.  So the end result was that I just decided to never miss another diabetic patient and I really immersed myself in this condition. So it was nice to take one of the most worst moments of my medical career and turn it into a real growth trajectory that makes me feel very comfortable treating all types of diabetes and kids and adults and so forth to this day. So anyway. Ben already showed the book. You can get it on Amazon. It’s pretty good book. I’m proud of it. Thanks.

Anyway, let’s dive in. There are some statistics just to know about. We’ll talk a little bit about type 1 and of course type 2, but most diabetes is type 2, 95% of diabetes is type 2, and it is related to many things which we’ll talk about, but obesity and being overweight and this abdominal, visceral fat is a big part of it. As we can see the U.S. statistics on obesity are staggering if we’re going to choose any appropriate adjective. Even kids, 15%, that’s so sad.

 Then in the world, right now, we got 8 million people on planet earth, about 2 billion are overweight. It’s not a good thing. With 650 million, about twice the population of the U.S. are obese. So this is not a good thing worldwide, and it’s certainly is feeding into diabetes statistics. So in the U.S. right now, when I did this lecture say when I started 60 years ago, it was only 29 million, so it’s now up to 37 and a little over million people actually have diabetes. Pretty much one out of every 10 people in the mall, or you are going to see has diabetes. Prediabetes is almost another 100 million.

So if we add that up, it is clearly one out of every three Americans have either prediabetes or diabetes at this point in time. With those senior populations, 50% of them have diabetes. You can’t even really wrap your mind around it. So it’s really not a good thing. It’s a huge burden for these people, for the health, for our healthcare system and for the economics of our country as well. In the world, we have right now over 500 million people in the world have diabetes. You can see the deaths and how many pre-diabetics there are. So if you add a pre and diabetes, really 1 billion out of eight people have either prediabetes or diabetes.

Now, the types of diabetes. There is type 1. This is our classic pediatric autoimmune disease. Doesn’t really tend to start below one and a half years. Then even though we call it kind of pediatric, really, the bell curve is going to fade out around age 25, so older than our 18 year old cutoff, but we still consider that’s all that initial pediatric type 1 type condition, right? It’s an autoimmune disease. In my next slide, we’ll talk about that TEDDY trial.

The other type of type 1 is called latent autoimmune diabetes of the adult, LADA. Generally, it’s kind of kicks in from age 35 on, but the vast majority tend to be in their 40s, about 40 to 60 is where we’re going to see that bell curve the most. Now, the big thing with this is that the vast majority of them are misdiagnosed as type 2. I’ve rediagnosed literally dozens and dozens of patients who came to me lean, always been lean, they have type 2, and it’s clearly type 1, right?

So just be aware of that. There are still many physicians that are not knowledge about LADA and are not aware of type 1 happening in adults. This type 1 can be very slow onset where they may not need insulin at first, or they may just need… I have one gal who’s just needed two units of a basal insulin for a decade. She hasn’t progressed. Or these people can come on just as rapidly as a pediatric type 1 and need full blown, full insulin from the get go. So you’ll just have to be able to figure that out with your own patient.

This is the TEDDY trial, stands for The Environmental Determinants of Diabetes in the Young, so TEDDY. So this is a trial that’s still ongoing where they’re following kids and the diets and their vaccines and et cetera, and they’re looking at all of these factors as triggers for what seems to really be an actual trigger that they can clock and start saying, “This is a determined trigger for type 1 diabetes.” So they are looking at a very broad based way of things from nutrient deficiencies to vaccinations and getting sick and psychological stress, all of these things.

So when they are able to quantify it and really put it together and put it out, they put out little bits here and there, but they haven’t yet put the whole thing together. I think that’ll be helpful to all of us to really be aware of what we need to watch in kids early on to help prevent them to not get type 1 diabetes.

Then of course the last type, right? Well, not the last, third of four, is type 2 diabetes, which is the number one diabetes. It’s insulin resistance driven. Gestational diabetes is an insulin resistance type diabetes. These are pretty well known etiological factors, and I’m going to talk about them more in the further slides to come, but all of these things can be factors with developing and also potentially having trouble controlling type 2 diabetes.

Dr. Weitz:                          By the way, doc, if a type 2 diabetic ends up being insulin dependent, has that type 2 now become a type 1 or is it-

Dr. Morstein:                     Yeah, that’s a good question. So, no. So type 1 is relegated to autoimmunity, and both you’re going to be able to pick up for the vast majority. There are always a very, very small percent of antibody negative type 1 patients. That just happens. But the vast majority will have a positive antibody or several positive antibodies. Type 2 diabetes is generally poorly controlled. These people will become insulin dependent type 2 diabetes. So they stay type 2.  There’s a lot of patients who need insulin with type 2 diabetes. For me, unless the patient is literally completely in denial and refuses to change anything about their diet or their lifestyle. There are some patients like that. But for a lot of them, they’re just given misguided information from the physicians they go to. Easily, the vast, vast, vast majority of type 2 diabetic patients never need to be insulin independent.

The last one is a relatively unknown one called MODY, mature-onset diabetes of youth. These are just genetic mutations. These you tend to see, well, grandpa had diabetes and dad had diabetes and Timmy at 16 gets diabetes. But it’s not that bad and they don’t really need insulin. This is mild elevations. Their blood sugars are around 140 or so. These are genetic defects. For example, they make insulin, but there’s a genetic defect in their ability to secrete it, or they can secrete it, but there’s a genetic defect on the receptor that it doesn’t acknowledge the insulin.  So these are generally can be dealt. Most of them have to do with secretion. So sulfonylureas, which are not good drugs that we don’t really like, for this group of people is a good drug, right? If they just take a sulfonylurea, they’ll be fine for pretty much the rest of their life. So there’s one lab, Athena Diagnostics, that does measure all of them, they measure 1, 2, 3, 4, 5, and 8 of the MODY genes, right? If you feel a child needs to be investigated that way.

Just to put it together, a little chart of MODY type 1 and type 2, non-insulin dependent or parents affected and so forth, Acanthosis Nigricans, et cetera, and racial groups, right? Certainly we know with type 2, obviously many Caucasians get it, but Pacific Islanders, Native, right? We’ve been studying the Pima Indians with type 2 diabetes since the ’50s. Definitely Hispanic populations, our African American, very high risk for type 2.

So diabetes, but controlled, nobody has any problems with diabetes when it’s controlled. But when diabetes is not controlled, right? Physiologically, the vast majority of our cells do have an insulin receptor. When this pancreas secretes insulin, it lands on the receptor, sets up this phosphorylation chemical, and then that initiates the glucose transporters, particularly 2, to reach out, grab glucose and pull it into the cell, turn it to fat and store it or burn it as well. But we know insulin is called the fat building hormone. Its idea is to store food for later.  So the problem is there are four cells in the body that don’t have insulin receptors and the glucose is just going to… Osmolarity just walk into those cells. So those cells are your eye cells, kidney cells, neuro cells, and the endothelial lining of the blood vessels, which is why those are the ones that get damaged with uncontrolled diabetes. Because if your blood sugar is 300, your eyeballs are 300. Meanwhile, your fat cells and muscle cells and liver cells, they’re like, “Forget it. I’m not taking you in. I’m going to be resistant.”

So they’re not getting the glucose in, but it is getting in these other cells that by the nature of survival never want to be without glucose so there’s nothing blocking glucose from entering those cells. But this is why the majority of people with diabetes have hypertension. When you have diabetes, considering if you’re just getting regular treatment and you’re not really well controlled, you have a four to six time increased risk of dying from cardiovascular disease, which is not a good thing because everybody dies of cardiovascular disease in America, so you are really at risk.

Chronic kidney disease. Diabetes is the number one reason people wind up with endstage renal disease. It’s the number one reason adults go blind. The first reason people get amputations is trauma. The second reason is diabetes. So pregnancy and fatty liver, most fatty liver, which in America is still called non-alcoholic fatty liver disease, in Europe and probably within a year or two in America, it is going to be called metabolic associated fatty liver disease, because that is a vast majority of fatty liver, right? So diabetes has outstandingly devastating complications.  This is like a daily diagnosis. We have 4,000 people a day diagnosed, 356 amputations a day due to diabetes. About 160 people wind up with endstage renal disease, et cetera. Literally, the amount of money we spend on diabetes in this country is very scary and could really become an economic burden for our country in the future.

Now labs. So this is like one page of labs to consider. Obviously, the basic CMP, CBC with different lipids obviously. I always draw Ferritin. I include Ferritin on every lab, a yearly lab that I do. Ferritin, one, it’s the first way to catch anemia. Before the CBC is affected, you’re going to see low Ferritin. So you can catch people before it gets very serious. But even more so, it’s the number one lab that shows, that indicates a person has fatty liver. When Ferritin is elevated, of course, you’ll do iron panel and look at trans saturation, and as long as it’s not over 50 or so, they don’t have hemochromatosis, and most people don’t have hemochromatosis, about 2% of the population, but when that’s negative, then you can do your ultrasound and see the echogenicity. So… your ultrasound and see the echogenicity. Ferritin is the number one blood lab. When it’s high, that indicates as, and that’s as a liver, acute phase inflammatory marker. The second one is elevated GGT.

Dr. Weitz:                          By the way, Doc, on ferritin, are you using the lab range over 400? What are you using as high?

Dr. Morstein:                     I am. Well, it depends on the lab. Some labs are over 250, some are over… Yes, I am using for high, I am using high. Yes, I am using high. If the lab range was 400 and they were at 380 and you wanted to test for fatty liver, because they have a adiposity as a body type. There’s nothing the matter with that. I’m saying, literally, you’re going to get a great deal of your overweight or obese pre-diabetic or diabetic patients will have elevated ferritin. You’ll do the ultrasound and they’ll have fatty liver.

Dr. Weitz:                          By the way, Doc, I don’t know if you’ve noticed, but recently, some of the lab ranges have gone up. I had a patient last week with ALT of 65 and I said, “Oh, your liver enzymes are up.” Then it said normal. It was an asterisk underneath. This was a UCLA lab. New reference range, it’s now up to 70 is normal.

Dr. Morstein:                     I don’t think anybody who’s a real… I Just did a webinar series with a hepatologist and things on liver conditions. They’re not going to agree with that.

Dr. Weitz:                          Well, this is the normal range is the average American as a result of two years of pandemic drinking.

Dr. Morstein:                     Yeah, of course. Totally. Absolutely. I once called Sonora Quest because they’re postprandial insulin range was from 29 to 89. Now, when you look at studies where they are measuring postprandial insulin, pretty much the cutoff was around 30 where they said that it should be not higher than 30. I called Sonora Quest to research, how did they get their range? Do you know? Sonora Quest said, “Oh, well we just took 50 of our healthy employees, measured their postprandial insulin and got the range.”  That’s literally how they set up the lab value. That’s measuring millions of people. The lab ranges, we do have a right to be a little question them at times. I agree with that. The other ones that you can see are fairly standard. Remember that as soon as someone injects insulin, you cannot measure insulin. You have to measure the C-peptide. Anyway, C-peptide is a better reader than insulin, I think, anyway.

You can’t measure insulin once if they’re a type one diabetes because, they’re going to probably have insulin antibodies. Or once you inject insulin, you’ll make insulin antibodies. We want to switch to C-peptide. The cardiac risk panels, because we know cholesterol is pretty bogus to judge cardiovascular disease risk. The other panels are, these are better. Random micro-albuminuria, you’ll want to check at least once a year, if it is elevated, showing early kidney damage, you can repeat it every three months. Those are the diabetic antibodies.  The classic one for LADA is GAD65, but I would just do the whole diabetic antibody panel. Because sometimes it’s not, GAD and it is a different antibody and you don’t want to miss it. Then of course, celiac, and Hashimoto’s, at least once a year with your type one diabetic patients, you’ll want to check Hashimoto’s if they’re literally gluten free, you can’t really measure for celiac. If for some reason they’re just going to eat gluten, then you’ll want to check that every year as well.

Dr. Weitz:                          What about the new kid on the block, uric acid?

Dr. Morstein:                     Oh, yes, uric. Well, so uric acid going back, yes, uric acid obviously, elevated uric acid, not just gout, but it is an indicator of also risk of kidney disease, even heart disease and patients with diabetes. I don’t do uric acid that much because I already know their risk. What’s their A1C, what’s their et cetera? I don’t do a lot of uric acid. I will do them, I’ll do the micro albuminuria. I’ll do other things. Yes, it is an indicated lab. If you just want to throw that in, for sure. Thanks Ben.

Now, just to say, this is the conventional A1C lab reference ranges, pre-diabetes and then diabetes 6.5% and higher. The problem is, is with A1C, one, it always has a 0.5 variability. If you get a six, it could be from 5.5 to 6.5. There’s always this little variability. Now, we do know the lower the A1C, these old studies are still referred to this day. The DCCT and the UKPDS done in the 90s, type one and type two, showing that literally lowering A1Cs from nine to seven, based on basic and then aggressive control, made huge differences in the occurrence of complications.  We still need A1Cs to be as low as we can. Unfortunately, even though they don’t count person being pre-diabetic until it’s at 5.7, studies will show that an A1C over 5.5 is already beginning to cause damage in the body, such as to the eyes. Or over six, it’s causing kidney damage. In the pre-diabetic range, people are already having damage. This is a problem, because people, “Oh, it’s five, seven, whatever. That’s not that bad.” Well, okay, it’s not that bad, but it is causing damage. We do want to get people under controlling and get them protected.

Dr. Weitz:                            I think there’s a misunderstanding of what hemoglobin A1C is. I think a lot of people don’t really think about it too much and they just say, “Oh, this is three months of average blood sugar.” Really, this means that proteins in your body are being damaged by sugar.

Dr. Morstein:                     Well, yeah, I mean the A1C is a protein on the red blood cell. What we’re measuring is what percentage is covered with glucose. An A1C of five is 5% of those proteins are covered with sugar and 6% is 6% of it. It doesn’t seem like much, but of course we can translate this to blood sugar numbers and they go striking each number decimal higher is about 26. Five is 100, six is 126, seven 152 and up. There’s a fairly exponential rise per percentage of this glucose bound to the A1C protein on the red blood cell. I do have this slide just showing, there’s different ways.  You can get an A1C of six. You can have steady, good control, or you can be up down, up and down all day with an average of six. If you are at 50 half the day and at 150 half the day, you could get an A1C of six. We have to be aware that you always want to monitor blood sugar, not just take an A1C, because we don’t know what the blood sugar is doing to get that A1C. Then here’s a very, very busy slide, just saying when the A1C can be inaccurate. There are different races have different A1Cs.

Of course, the genetic hemoglobinopathies, if you do have a patient with a genetic hemoglobinopathy, like a sickle cell, you can’t really use A1C, you’d have to use fructosamine, instead. The only problem with fructosamine is that it doesn’t translate to a glucose number. It’s just low, normal, or high, but we can’t translate it into glucose like we can in A1C. Then different, depending on how, if they have serious liver, then the A1C can lose efficacy as well. Liver, kidney, iron anemia, et cetera. Last, the problem with the A1C also was these studies.  These studies, particularly the Accord. The accord was a study where they had people eat whatever they want. Because why would we ever deal with the diet in measuring medicines? They had people eat whatever they wanted, their goal was to get them less than 6.5% of an A1C. As a result, they had to use a lot of strong medicines, which was sulfonylureas, which caused weight gain and the water retention. TCDs, which cause weight gain and water retention, and insulin, which causes weight gain and water retention. They had a high amount of people dying.  As a result of this study, I can’t tell you the amount of patients who come to me and say, “Oh, my doc doesn’t like that. My A1C is at 5.8 and literally wants me to eat more carbs to get it higher, so I don’t have cardiovascular disease because of the accord study.” The accord study, that’s all we, and then the advance, these studies use the worst drugs that we have. This accord study is what took the TCDs off the market.

Now, they’re back on, but very rarely used. Probably all of you have also heard patients say, “Oh, my endo doesn’t want me to get less than 6.5, because I’ll get heart disease.” This is ridiculous. It’s solely based on the accord. If I get a person on a diet and supplements and maybe Metformin down to 5.4, trust me, they are not going to have a high-risk of cardiovascular disease. Just to be aware. The ADA has these glucose goals. I think we all want it a lot more stringent.

Because we can get it with the way we’re doing it versus the way the ADA tends to do it. Getting everything down back to as much normal as possible is the goal. These are the diabetic medications, there are insulins, they’re basically split to basal, which is covering the fasting glucose, which is either long-acting or intermediate. NPH is the worst insulin we have. Certainly, by far, has the highest rate of hypoglycemia. Very hard to deal with. Some people need it twice a day. Some people need it three times a day. It can last for eight hours.  It can last for 15. It’s a difficult insulin, but it is super-cheap. That’s why we’re seeing a little resurgence of it now in patients who can’t afford insulin as it’s priced now. Although I order a lot of insulin from Canada, it’s much cheaper there. Or people I have patients just drive down twice a year to Mexico and get their pens from nothing, just walking into the pharmacy. Then there’s the bolus, which is meal or correction. We have short-acting, regulars by far are the best for meals, but isn’t used very much nowadays for a couple of reasons.  The rapid-acting, and then the very rapid-acting, which acts within five minutes. These are our insulins. We have the oral hypoglycemic. There’s nothing the matter with Metformin. You’ve got Metformin, and then you’ve got the ER, because some people who can’t handle Metformin in the gut, the ER, they will be able to handle the extended relief. The sulfonylureas are problematic drugs, they do cause water retention and weight gain. They have the high-risk of hypoglycemia.

Glyburide is the worst one for low blood sugar, so we’d want to stick with Glimepiride. The mitiglinides, nobody uses. Why would we use this? I could take a sulfonylurea maybe once a day for 24 hours. Why would I want to take a tiny sulfonylurea with every meal? Nobody uses them. The TCDs, I just saw a patient on one for the first time in nearly a decade. The sodium glucose transporter to inhibitors, not bad drugs, except the sugar can cause bladder infections or jock itch or vaginal infections, but most people don’t have this recurrently.

You can get a euglycemic DKA in type twos, which sucks. You have to be like, people be aware of that. Then you have the DPP4 inhibitors, which don’t seem to be a problem very much. It’s just that at the highest dose, they have a lowering of the A1C of like 0.4, 0.5. Frankly, just taking out their grains will lower them 3.3%. They’re fairly useless drugs. They don’t do very much. Then we have the Glucagon-like Peptide-1 agonist, these are good. These are great. Patients like them. Most of them can handle them, even with the nausea. Once a week shot, they can lose a little weight.

Their appetite is better. Their blood sugar is better. These are well, good drugs. They’re just spendy, and so people have to hope their insurances will cover them. Otherwise, people are using for insulin, vials and syringes or pens or pumps, and then the CGMs. Dexcom is pretty good. FreeStyle Libre for the type twos, is pretty inaccurate. People get it, but it is not the best CGM.

Dr. Weitz:                          Dexcom is more accurate than-

Dr. Morstein:                     Yeah, Dexcom is 100% more… I was trying to go backwards. There we go. Dexcom is 100% more accurate than a FreeStyle Libre, absolutely.

Dr. Weitz:                          I know Dexcom usually recommends wearing it on the abdomen. I’ve seen some people put it on in the back of their arm. Is that acceptable? Do you know?

Dr. Morstein:                     Yes. That is acceptable. Also, back here in the back, is also acceptable. it’s just subcu. For example, this is probably the most common area people wear their Omnipod pump, which is in the back here. People love wearing their Omnipod here, and it’s the exact same technology and depth. With the Omnipod here, you can have your Dexcom here.

With diets, so in 2013, ’14, the ADA did acknowledge that low-carb diets have value in working with diabetic patients.  Now, if we go back, what happened with the ADA is that, diabetic patients say that needed, type one diabetics 100 years ago before Banting and Best were inventing insulin in Toronto. We didn’t have many type twos and the type ones would die pretty awful deaths where they just ate themselves. We invented insulin and diabetic patients were able to live longer until they all died of cardiovascular disease. They’re doing autopsies on all these patients with diabetes and they had cholesterol in their arteries. If you go back to the 70s, that meant their fat was too high.  That was 1978 was when the country said, “Wow, we should all eat low-fat.” Everybody started eating all these carbs and things went downhill from there. The ADA said, “Yeah, we’re seeing all this fat in these autopsies, so we should have a huge amount of carbs in our patients with diabetes and not much fat.” This has been going on for decades until recently, just in the last years, they’re turning around, which is something for them to do. They started acknowledging low-carb diets is, a physician could do this in an acceptable way.  

For prediabetes, this PREDIMED diet is very well known where they did Mediterranean diet versus low-fat and even Metformin. The Mediterranean diet, which is really just a super-healthy, non-processed food, omnivore type diet. Here’s the study and, the Mediterranean diet with olive oil or nuts and no calorie restriction reduced diabetes incidents by 52%, which was higher than putting people on Metformin. In other words, just eating a healthy Whole Foods omnivore diet with good oils can prevent diabetes.  This is what pretty much everybody was eating until they invented fast foods and candy bars. This has been a diet for humanity for centuries, and it works to not get diabetes.

Now, this is an outlier, I think we need to discuss, which is the MAPI2 diet. This is the high-carb plant-based diet. There is a company there. Actually, I wrote a book, Master Your Diabetes, but the mastering diabetes folks are doing this diet. They’re doing this high-carb, plant-based diet.  There is actually good studies on this diet. They did a six-month study of this diet. Now, this was all men. This was all type-two diabetic men who had pretty high A1Cs, and this was the typical diet that they ate. Now, the mastering diabetes people aren’t doing macrobiotics. This diet was what we classify as macrobiotic. You can see just all kind of foods that we wouldn’t think people with diabetes should eat. The results were outstanding in every area. The A1C from 12 to 5.7, pretty amazing.  Things like HDL went up, LDL went down. C-peptide actually raised a little bit. This is their lipids, the onset. After months, from acceptable, there was only 31%. After the six months, almost 94% of the patients had acceptable triglycerides and pretty good stuff. They had weight loss, they lost hip circumference.  Their BMIs went down, their muscle mass gained. This is everything we want to see, eating this diet. Now, these guys were fed this diet. This is a hard diet for people to put together, but in the study, they were delivered their meals. They just got everything fed to them. Now, this is kind of, I copied and pasted. This is from the Mastering Diabetes Group, and you can see what they want you to eat a lot of, which is, grains and legumes, veggies and fruits.  Then what they want you to eat just a little bit of, which is, things like pastas, avocados, because they’re worried about too much fat, especially saturated fat. Nuts, which is too much fat. Then there are other things that they don’t want you to have at all, which is meat and poultry. Part of this is the idea that animal protein, I think interpreting this, I went to a lecture from Dr. Joe Pizzorno, who’s a naturopathic physician. Brilliant. He did one of the best lectures I’ve ever seen, which was on cellular acidity, right? Now, in reality, our blood doesn’t really change alkaline or acid because tiny changes are so devastatingly bad, but the cell, we’re looking at intracellular, there can be acidic changes. And animal protein and salt are two of the main, main, main foods that cause the acidosis and that is causing insulin resistance. So in this diet, removing all the animal products is really pulling out that whole thing. The problem is you can’t eat half this diet and half of the other and have it all merge. This diet will work 100% its way or low carb will work 100% its way, which is what we’re going to talk about right now. Right?

So low carb, for diabetes, we’re usually looking at 40 or less carbs a day. Okay? The studies on low carb, there are a lot of studies on low carb, but this one that I want to show you, if you look at the authors on this study, first of all, Richard Bernstein, Richard Feinman, huge low carb, there are some really well known low carb researchers, Westman, Eric Westman, big keto guy. And so they did this study showing being a dietary carbohydrate restriction, first approach in diabetic manage, and this is what happens when you are doing a low carb diet, pretty much everything we want to have happen for people with diabetes. So this was with type two diabetics.

Then managing type one diabetes with very low carb diet, this was published in pediatrics. This wasn’t a study so much as it was a survey. And they surveyed a group on Facebook called type one grit, which is a very, very passionately low carb group for type one diabetes. Notice Bernstein and Westman are in [inaudible 00:48:45] these same people. Dr. Richard Bernstein, by the way, was my mentor. He wrote the book, Dr. Bernstein’s Diabetes Solution. He was the one who brought low carb diet to diabetes. He also was the one who taught us how to use insulin better. For example, using insulin to cover carbs, to cover protein and to figure it out in a completely different way than conventional care. And that works a lot better. David Dikeman, he’s a big low carb guy.  So they did this survey of parents of type one. And here’s the exceptional glycemic control of type one diabetes without adverse effects was reported by these people and their kids on a low carb diet with type one, with the reported mean of A1C at 5.6, which is pretty outstanding. So low carb diet is what most of us work with and what most of us want to do. But if one of my patients really wanted to do mastering diabetes, 100%, I don’t mind. The studies are good. They’ve been replicated. But you’ve got to choose one extreme or the other. So it’s total carbs minus fiber. It’s not the amount of sugars on the label. It’s total carbs minus fiber, right? That’s what a label should be. And these are the low carb nos, pretty much, right? The big groupings of foods that we’re taking out of the low carb diet, right? Which you probably know about.

And then Bernstein set up the idea of six grams of carbs at breakfast, 12 at lunch and supper because of the Dawn phenomena at breakfast raising our blood sugar innately. And so having less carbs at breakfast, and then as we’re up and moving around lunch and supper, we can have a little more then. And fat is a free for all. And protein is also weighted a little bit as well. We don’t want to overdo protein. We do need people getting in calories though and having energy and so forth. So we do a little. The protein is one gram per kilogram versus 0.8 for adults in general. And then we allow fat to make up many calories too.

I mean, obviously you all know how beneficial exercise is to people with diabetes with metabolic syndrome, prediabetes, people who are overweight and et cetera. It does pretty much everything we need it to do to help reverse that in patients. And then we can put it obviously aerobic. Resistance does burn 19 times the glucose that aerobic does. Now, I’m not talking if you’re going to decide to do a 10 mile hike with 3000 foot elevation, then the aerobic is going to work pretty well. But if you’re a half hour on a treadmill versus a half hour of lifting weights, you’re going to burn more glucose with the weights, right?

Dr. Weitz:                          Hey, Doc. Can I just ask you question about the diet, just to go back for a second?

Dr. Morstein:                     Oh, yeah. I’m sorry. I didn’t need to. If I’m-

Dr. Weitz:                          No, that’s okay. Yeah. So the low carb program you’re outlining, less than 40 grams. That’s very, very low carbs. Can you get a reasonable benefit with, say 50 to 100 grams? A lower carb program reduces the high glycemic carbs, takes out the refined carbs, but say the person has maybe a slice of gluten-free toast in the morning with their eggs and they have a yam with their dinner, and maybe they have some beans with their salad at lunch.

Dr. Morstein:                     I mean, they’re going to see elevations in their blood sugar. It just depends on how much, right? But generally, no, if you’re following low carb, those are not on the diet for low carb. Now, why not have a piece of base culture bread. Or if you go to a dietdoctor.com, dietdoctor.com has amazing recipes. They have these rolls, which are six ingredients. You mix them together. You bake them. You get these super tasty rolls that are two grams of carbs per roll. So the idea is there’s low carb bread, there’s low carb tortillas. You can make your own low carb rolls. Birch Benders has low carb pancakes. You can get Shirataki noodles.

So the idea is when you’re working with patients this way, here’s the deal, for every 20 seconds you spend taking some food or food group out of a patient’s diet, you want to spend about five minutes adding in the alternatives, because otherwise their psychology starts getting narrower and narrower and narrower. And it’s not like they have to live. They could have base culture. A slice of base culture bread is four grams of carbs and four grams of fiber, which is going to even further reduce the carbs that they eat. So if they have a sandwich at lunch with base culture bread, that’s eight grams of carbs, eight grams of fiber-

Dr. Weitz:                          What kind of bread are you saying? It’s not something I’ve heard of.

Dr. Morstein:                     Oh, it’s called base culture. B-A-S-E culture bread.

Dr. Weitz:                          Okay.

Dr. Morstein:                     So I’m saying that there are breads that people can eat, that will work for them without it being Dave’s Killer bread, which you can’t have. No, you can’t have this, you can’t have Ezekiel bread, but try this bread or try this granola. I have a reference sheet that once I go through, I have a eight or 10-page diabetes handout for the diet. So we go over everything. Then I have a reference sheet with recipe books, 300 15-minute low carb recipes. Oh, you want maple syrup? Well, guess what? Nature’s Hollow has it, Birch Benders has it, Lakanto has no carb maple syrup made with monk fruit, right? So if you give people some of these alternatives, so the diet isn’t this whole change, they can still have some things they really like, but it’s low carb and it’s going to do what we want to have done, that’s how this is a successful protocol for them, right? That’s how they buy in. And that’s how they have success with it.

Dr. Weitz:                            So in your opinion, you want to have success with the type two diabetic, it’s got to be super low carb or you’re not going to be successful.

Dr. Morstein:                     Yeah. That’s how I work with patients. Yes, yes.

Dr. Weitz:                            Okay.

Dr. Morstein:                     Now, otherwise, the rest of the exercise, I’m sure you had plenty… The only thing with exercise is that if they’re insulin-dependent, I have a whole lecture on doing exercise with insulin-dependent diabetics, because depending on the intensity, the length, so forth, you are going to have to figure out how to deal with their insulin before, during, and after. So you can get pretty good at it. You just need a little data to make these decisions, but that’s the most difficult patient to work with initially, are the insulin-dependent who are starting to really dive into exercise.

Dr. Weitz:                            So Dr. Watson [inaudible 00:57:44], you showed some slides about the Mediterranean diet as being helpful in preventing diabetes. But now you saying no way.

Dr. Morstein:                     No, no, no, no. That’s if you don’t have diabetes.

Dr. Weitz:                            Oh, okay. That’s preventing it from happening.

Dr. Morstein:                     That is preventing it. Now, if you have it, that you’ve stepped over that line and now we got to yank you back a little more tighter. So yeah. Now, I just have some things with blood sugar and exercise. It doesn’t matter where the blood sugar is when they start in terms of how well they’ll be able to exercise. The golden is I don’t agree with this 65 to 180. I tell patients to mostly be around maybe 80 to 170, if they start exercising around there, they’re going to have better effect. And the same with where their insulin levels are, if they’re on insulin and how it’ll affect their performance. So I’m working right now with a 16-year-old teen, who’s a cross country skier and has desires to get into the Olympics and so forth. So we’ve been getting really good at figuring out his food and his insulin before and after his races. So you just need a little data a couple times and you can figure this out if you have some aptitude with insulin and work with patients who are also athletes.

Dr. Weitz:                            Do you recommend a insulin pump?

Dr. Morstein:                     I’ll let patients decide what they want to do. Some patients for sure, do not want something embedded in them, 24/7. They just don’t. Other patients love it, because they don’t have to inject themselves five times a day. And you can have good control or bad control with any system, right? And you can also have success with any system. Now, pumps do give us a better control of basal insulin because we can direct the basal all throughout the day, exactly how that patient needs it versus I just inject in the morning and I just inject in the evening and there you go, it’s set. So pumps are the best for basal. They’re not good for meals. You can’t use the pump to decide what meal your insulin you’re going to do because they’re just doing the typical conventional figuring out of glucose, which is not a good way to do it.

So you’re going to have to still figure out your insulin for the meal and then tell the pump what to inject. But it is good for basals. It’s just that you can’t demand a patient get a pump and not every patient wants them. So you’re going to have to work with the basals else-wise, right?

In terms of stress. So this was an interesting study. It was stress management. Everybody was a type two. They had treated, which was one and a half hour groups for eight weeks. And in the people that got stress training management, look at their drop in their A1C. I mean, this is ridiculous. That’s better than any medicine, any oral hypoglycemic, or even better than a GLP-1. The stress management is dropping better than any of those medications versus the control, which had really no statistically significant drop. And the thing with stress is that stress can worsen diabetes, but diabetes can worsen stress. So we have to be aware of the psychology of having diabetes. “What am I going to eat? I have to check my blood sugars. I thought I ate right and yet now I’m at 170, this sucks, blah, blah, blah. I’ve been exercising more. My A1C is still 6.6.” I mean, it’s an intense condition and it’s 24/7.

So we want to be there always for patients. We always want to be finding everything positive that we can, giving them support, acknowledging when they get burnt out and helping them work through it, right? But the arrow is both ways. With the microbiome, again, its own lecture, but we have seen that with type one diabetes, they have found elevated Zonulin and Occludin in patients who have positive type one antibodies, but have not yet had the clinical disease show up. Right? So, that’s interesting. So we also know that short chain fatty acid, right, so fiber fermented by the Firmicutes bacteria family turns to short chain fatty acid, which is really, it’s the food of the colon cells. But it does a lot of things systemically. One is help produce GLP-1 from the intestines, which will help us monitor our blood sugars better.

So are people eating enough fiber? In fact, even with a low carb diet, we do need to make sure they’re getting enough fiber in. They may need a fiber supplement because low carb diets have been shown to decrease the amount of the Firmicutes family, which are the fiber eaters and short chain fatty acid producers. So we do need to make sure that they’re getting good fiber in on the low carb diets.

Dr. Weitz:                            Yeah. There’s a company that’s now producing [inaudible 01:04:09] and they have it in a product that’s been shown in a study to help manage glucose.

Dr. Morstein:                     Yeah. All right. That’s good. Yeah.

Dr. Weitz:                            That’s one of the [inaudible 01:04:19] producers.

Dr. Morstein:                     I will admit I’m very wary of any one probiotic really working systemically if everything else isn’t coming together. You know what I’m saying?

Dr. Weitz:                            Sure.

Dr. Morstein:                     Now, the lipopolysaccharides, so these are associated with type two diabetes, insulin resistance and fatty liver. So having a healthy gut on many levels, fiber that makes short chain fatty acids, it’s not leaky. It isn’t overproducing the lipopolysaccharides. These are all gut oriented ways. We know that gut tumor necrosis factor alpha can get into this systemic system and go to our muscle cells and produce insulin resistance. So the gut is pretty, really important. Having a very healthy gut is… Here’s another study with endotoxins and diabetes. So type ones who had the macro-albuminuria had higher LPS. They had higher LPS in patients with diabetes and hypertension.

So it’s amazing how these gut problems can cause havoc so systemically. And then with environmental detoxification, even the World Health Organization wrote that lead and arsenic causes insulin resistance and an increased risk of diabetes. Mercury as well. Now the PCBs, the PCBs are very well studied for gaining weight and becoming diabetic. The phthalates, which I may have spelled wrong. I don’t know. It’s hard to spell the word phthalates. And then they study the Canadian Aboriginals with their high risk of diabetes, a much higher body mass of environmental chemicals. There is this organization, diabetesandenvironment.org, it’s a nonprofit created by a researcher woman whose son developed type one diabetes. And she collects all the research on environmental impacts on type one and type two diabetes. And she has a free newsletter that you can get, I think it’s every week or at least every month.  Sarah, somebody, I forget her last name. But I think one of the most important studies was this bottom one that I made red. So they had two groups of obese patients that were equaled out in age and smoking and drinking, all of that was the same. And then they had, one group had diabetes and one group didn’t though they had the same obesity. And what they found that was different in this group with diabetes was this significantly higher levels of persistent organic pollutants in their fat through fat biopsies. So you’ve got overweight people. Who’s going to turn into a diabetic? Likely the one that has more environmental chemicals in them, such as POPs, PCBs, et cetera.

So it’s pretty frightening given how much people use these at home and it’s on our food. And if you walk into a store, I mean, they’ve been spraying toxins for bugs and stuff. We can’t get around it. You see this fantastically horrific statistic that newborns have almost 300 chemicals now in their cord blood. It’s crazy. So we do want to detox patients, getting their house clean, no fragrances at all. Have all their supplies and body stuff being clean, using natural weed killers or pulling them. Here in Arizona, there’s an exterminating company that’s all organic. I used to use them now [inaudible 01:08:47]. Yeah, I had a big ants problem. The ants suck in Phoenix. But they would come and they’d spray peppermint oil, literally. Not in the house, they never sprayed in the house, but outside they would go and- They never sprayed in the house, but outside they would go and they would spray peppermint oil. But honestly now diatomaceous earth works fantastically. We got to retrain people to not have all these chemicals around in their own homes and then to detox.

Now sweating, there’s loads of studies with sweating. I have them, I didn’t put them on the slide, but sweating releases chemicals, heavy metals, even micro toxins like okra toxin has been found in sweat.  When I went to medical school, when we did dead lab, just working on cadavers, it was in an old RV that didn’t have any ventilation. It was disgusting. Of course all the formaldehyde. And so what we would do is, of course we wore onesies of plastic and whatever, but nonetheless, as soon as dead lab was over, we’d run to our gym, which had a sauna. So I’m in the sauna, maybe 20/25 minutes after class and I could taste the formaldehyde coming out of my skin. I could literally taste it, in the sweat. It’s crazy.  So people don’t sweat in America because it looks, oh my god, I have an arm thing. So we want to teach patients always sweat, wear enough clothing so that when you exercise, you sweat, get a sauna, sweat in it, go out and sweat, just sweat, it’s so detoxifying.

And then there’s many other things with detoxification that I’m already probably boring you in overtime, but I don’t have time to do it, but you guys already probably know how to detox mold or chemicals, heavy metals. All of these can be a problem for diabetes. But number one, if someone’s finances are limited, you definitely want to do chemical testing. That’s number one for sure.

Last, this is my last section, is supplementation. Supplements do everything from better mood to antioxidants. Now, diabetes causes damage through oxidative pathways. That’s what it’s doing. There’s the hexosamine pathway, there’s a browning pathway. There’s many pathways of pro oxidative damage going on in the body, that’s causing diabetic damage. You always have to put people with diabetes on antioxidants, aside from other ones, I will always put people on a multivitamin. I always put people on a fish oil, but the next thing is antioxidant protection so their blood sugars will not cause damage in that regard. And not only that, but you can reverse neuropathy, you can reverse kidney damage.

 I have an obese guy who went off the wagon over the last couple of months, on his diet. He had positive random microalbuminuria. And so I have him on some antioxidants and I have him on this great tincture, it’s from Heron Herbs, it’s called Two Treasures. It’s a such a great kidney protection formula. And so he’s on it. And so even though his A1C went up, his kidneys remarkably got better because of the antioxidants and the herbs, which was amazing and surprising, but beautiful to see. His kidneys really got a lot better. So our antioxidants and our supportive products really can make a difference in these patients.

Dr. Weitz:                            What would be your full program for a patient with kidney disease as far as supplements?

Dr. Morstein:                     Well, let’s go through some of them, and I’ll give you a [crosstalk 01:13:20]… I have a supplement summary [crosstalk 01:13:23]…

Dr. Weitz:                            Okay, good.

Dr. Morstein:                     Now for Type 1 prevention, fish oils reduce risk and so does vitamin D3. There’s no reason an infant can’t be on 1000 IUs a day. And if his breastfeeding mom can take fish oil, which mom should, because fish oils are really good at preventing postpartum depression, for her to take it during pregnancy and afterwards, or I would just do that through the breast milk for a breastfeeding newborn.

But as they get older putting them on fish oils and vitamin D, this is just a good thing. Especially if there’s, God forbid, any autoimmunity in their family. Now, if they develop a honeymoon, there are studies that showed these niacinamide alone or with vitamin E actually can help prolong the honeymoon. Now you might also want to throw in a pancreatic glanular, you might also want to throw in a Gymnema Sylvestre, an herb that has been shown to help revive the pancreas and even increase the C-peptide and it is not niacin, it’s niacinamide. But you can see it doesn’t prevent people from getting diabetes but if the kids enter a honeymoon period, this can help extend it. And honeymoon periods, they can go for years. I have worked with kids who had seven year honeymoon periods. It can also just last for weeks, so we don’t ever really know. But we want to try to extend that as long as we can, if the child initiates it to begin with. We never really see it in our Type 1 adults.

Now supplements. So if you’re adding supplements you’re not going to have to adjust the insulin, it’s not that extreme, so don’t worry about that, okay?

Benfotiamine, if that’s how you pronounce it, is a fat soluble fireman. Now this kind of twists us, because we usually think fat soluble is a little harder to absorb than water soluble, but not benfotiamine, it’s much more absorbable. And you can see the biochemistry where it’s becoming the cymene pyrophosphate, it increases transketolase activity and that blocks glucose damage. It prevents that browning glucosylation of sugar landing on protein, and so that’s what it’s blocking and this is amazing and it’s very good. The therapeutic dose is around 450 milligrams. And there’s studies in protecting neuropathy, retinopathy nephropathy. Well, that’s what we’re looking for, right? So it’s totally safe.

 I have a product, this is totally proprietary formula, but I made a product called Diamend and it has benfotiamine in it at therapeutic dose, but even if you’re just doing it by itself, it’s a really good product, mixing it with alpha-lipoic acid or just giving alpha-lipoic acid and particularly R alpha-lipoic acid, because the S alpha-lipoic acid is not active in the body, but the R is. So, this is also shown to normalize AG formation, advanced glycosylated end products, hexosamine is an oxidative pathway. So it’s really helping people.

Dr. Weitz:                            What dosage of lipoic or R lipoic acid…

Dr. Morstein:                        You’d want to do at least three to 600 milligrams a day of R. Now, if you’re doing just alpha-lipoic acid, which is half R and half S, then you’d want to be around 1200 so you get that 600 of the R and you could throw out in your body the 600 of the S.

Other supplements, vitamin C preventing the aldose reductase pathways in your eyes. So when you have a blood sugar of 200 and your eyeballs get 200, that’s too much stuff in your eyeballs, so it starts off shooting off a lot of antioxidants to keep the osmolarity from I guess, your eyes from blowing up. So, meanwhile then, that’s turning to sorbitol and the antioxidants are thrown out and we get fructose, and then we get cataracts, we get retinopathy and so forth.  Now, vitamin C and bioflavonoids inhibit that initial pathway. The problem is we have to watch vitamin C with people with diabetes no more than 1500 a day, because it looks like glucose, and it can raise glucose levels on some glucose meters. We know that when we give IV glucose, usually people need to have a snack, because that can kick out their insulin and lower it when we are giving vitamin C. So, a little C and bioflavonoids are fine. The alpha-lipoic acid, NAC, N-acetyl cysteine does a lot of stuff for people with diabetes. Of course, we always think of it producing glutathione and liver and lung protection, but it does decrease insulin resistance, and of course, a very good antioxidant in general. So [nic-taurine 01:19:43], good for the eyes, especially with retinopathy, it’s the number one amino acid in the heart. Of course, it does help make a bile salt in the gallbladder, but that doesn’t tend to be necessarily a big thing with diabetics. The fatty liver could make a gallstone however.

The acetyl-l-carnitine at 1500 to 3000 milligrams. Even Diabetes Care Journal, which is from the ADA journal has good studies showing how it reduces peripheral neuropathy. A very good safe one.

Magnesium tends to be the number one nutrient deficiency in patients with diabetes. So maybe checking their red blood cell magnesium as well.

The Gymnema Sylvestre, which is called Gurmar in India, sugar destroyer, decreases cravings, helps increase pancreatic functioning. Here’s a really great thing for your patients who have very little willpower, particularly around the holidays, is that if you have Gymnema Sylvestre in a tincture, I used to do this when I was at the medical school and saw students, we would eat a little organic raisin, so sweet, then put a couple of dropper fulls of Gymnema tincture in your mouth for about a minute and then swallow, and you can’t taste anything sweet for up to one and a half hours. So you put raisins in and they’re these disgusting things you can’t taste, you have to spit them out.  So for patients who cannot control their cookies at the holiday parties, put some Gymnema in their mouth and swallow it and they can’t taste it, they’ll have to spit it out. You can’t eat it, it’s really intense. Very helpful.

And then of course, curcumin just awesome, tumor necrosis factor alpha, as I said, is an insulin resistant factor. It’s an antioxidant, it’s an anti-inflammatory, we know it reduces Alzheimer’s in diabetic patients. Ben already did all the talk about berberine. I do have the method of action [crosstalk 01:21:58].

Dr. Weitz:                            By the way, do you have a favorite form of curcumin?

Dr. Morstein:                     Oh, curcumin for sure. I think the best is Designs for Health Curcum-evail; that stuff kicks butt, I think, so that’s the one I use, it’s Curcum-evail by Designs for Health. And then here’s the berberine method of action, it’s just like he said, the AMPK, everything it does. Green tea, blueberry. If I had to choose between Gymnema and bitter melon, I will always choose Gymnema myself. Of course, we have the old cinnamon studies, like the one, the two and the six grams a day, how it helps, it doesn’t hurt anybody to do cinnamon. They have done a lot of studies on it.

Dr. Weitz:                            Doc, what dose of Gymnema Sylvestre?

Dr. Morstein:                     Oh, with Gymnema, anywhere from three, in my product there’s a thousand, but anywhere from 400 to 2000 is a good safe dose, and you should see some effect. So, if you have patients who have proliferative diabetic retinopathy and you’re going to lower the blood sugar, you could cause them to have a bleed. And you cause them to have a bleed because when the blood sugar goes down, the insulin goes down, but then insulin like growth factor comes out and that causes angiogenesis. And that causes a bleed.  So I did cause a bleed in a patient with PDR early on, and that was horrifying because they needed laser, it was a fiasco. You feel terrible. But then I decided to not have that happen anymore with patients who had PDR. I know it looks like a lot. They only need to be on this for a month or two with the initial lowering of the blood sugar.

But, in two other patients with PDR, they never had any problems with their eyes. It was very stable. Now I put everybody on a multiple vitamin and fish oil. I will use my diabetic product, which means it contains alpha-lipoic acid, it contains bilberry and NAC and benfotiamine, so that product contains that stuff. So I would add in taurine and a little selenium, and you’re going to protect these eyes so they don’t bleed with the sudden drop of the blood sugar in their eyes.  But before you do a low carb diet, patients are like, I haven’t been to the eye doctor for a couple of years; you’re like, okay, you go and when you’re done, come back, because I’m not going to put you on a protocol until I know what’s going on with your eyes.

So this is basically a multiple vitamin, mineral, fish oils, comprehensive diabetic product, or breaking it down individually, probably some vitamin D3. I use vitamin D3 complete, from allergy research, that comes with vitamin A, because you need vitamin A, because the vitamin D receptor is bound to an RXR receptor, a retinoid X receptor. So if they don’t have enough vitamin A, their vitamin D receptor won’t work and the whole process doesn’t work. So you have to throw in a little vitamin A, K and so forth. So, that’s my lecture. I’m sorry if it went too long.

Dr. Weitz:                            No, no, it was awesome. Can you mention that herb that helps with kidneys?

Dr. Morstein:                     Yeah. I can write it. Should I write it in the chat?

Dr. Weitz:                            That’d be great.

Dr. Morstein:                     So it’s from Heron. So it’s Heron Herbs, which is owned by Eric Yarnell, who is a master herbalist. And his specialty is men’s health and kidney health. And so he made this product called Two Treasures and it’s a tincture. And so that’s what I use, I use that with patients who are on lithium, people who have kidney damage for whatever reason, it’s a really [crosstalk 01:26:45].

Dr. Weitz:                            Yeah. If you have a patient with chronic kidney disease, what would be your full program, what else would you put them on?

Dr. Morstein:                     Well it depends. If it’s a IGA nephropathy, I’ll do food sensitivity, testing of IGA, not IGG, but IGA. I use Alletess and they have an IGA option. They have IGG. So I would do that tidy up the diet. Fish oils are great for the kidneys, Ginko and salvia miltiorrhiza is great. This Two Treasures is great because it has a lot of the other herbs, the [Peristeria 01:27:28], the rhubarb, all of the other herbs that, we have science, I have a whole lecture, I think I might talk about it in my book, but I have a lecture on treating, more specifically, complications in patients with diabetes. And I go over the science and the herbs and so forth with them, but you’d want to do cordyceps. There’s a naturopathic physician, Jenna Peterson who had kidney disease and that’s her whole practice, is treating kidney disease. She wrote a [inaudible 01:28:03] article and said for sure cordyceps with kidneys as well.

Dr. Weitz:                            [inaudible 01:28:10] data on astragalus?

Dr. Morstein:                     Well, she specifically said cordyceps.

Dr. Weitz:                          Okay.

Dr. Morstein:                     But, when is astragalus going to hurt anything.

Dr. Weitz:                          And of course, we have modified citrus packed in.

Dr. Morstein:                     Yeah. I don’t use that for the kidney very much, mostly I use to prevent cancer metastases, but I haven’t used it… Oh, thanks. Thank you. So, I actually haven’t known to use that for the kidneys.

Dr. Weitz:                          Yeah. Apparently it prevents fibrosis, chronic kidney disease, there is some data on it.

Dr. Morstein:                     Luckily so does the alpha-lipoic acid and the benfotiamine.

Dr. Weitz:                          Okay.

Dr. Morstein:                     So for sure.

Dr. Weitz:                          Excellent. Okay. Well, that was awesome doc.

Dr. Morstein:                     Thank you. Thank you. Thank you everyone, I appreciate that. Thank you.

Dr. Weitz:                          Absolutely. And thank you everybody. See you next month. Thank you, Mona.

Dr. Morstein:                     Okay. Take care, Ben.

Dr. Weitz:                          Okay, bye.



Dr. Weitz:                            Thank you for making it all the way through this episode of the Rational Wellness podcast. And if you enjoyed this podcast, please go to Apple podcast and give us a five star ratings and review. That way more people will be able to find this Rational Wellness podcast when they’re searching for health podcasts.  And I wanted to let everybody know that I do now have a few openings for new nutritional consultations for patients at my Santa Monica, Weitz Sports Chiropractic and Nutrition Clinic. So if you’re interested, please call my office 310 395 3111 and sign up for one of the few remaining slots for a comprehensive nutritional consultation with Dr. Ben Weitz.  Thank you and see you next week.