Dr. Sarah Ballantyne discusses Nutrient Density with Dr. Ben Weitz.

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Podcast Highlights

1:40  Nutrivore marks a departure for Dr. Ballantyne from the Paleo diet that she previously endorsed as the Paleo Mom, to a more diverse nutritional approach focused on increasing the nutrient density of the diet.

4:45  Food myths.  Chapter 10 of Nutrivore busts many of the myths around food.  Dr. Ballantyne argues that animal foods are not bad for us and she discusses some of the myths related to food quality, olive oil, and organic foods. She argues against the idea that we should avoid eating legumes and grains because of them containing lectins, phytates, and oxalates, which is the argument in paleo circles why we should not eat whole grains or legumes.  Legumes are among the most nutrient dense foods, including being one of the best sources of folate, are mineral rich, and contain lots of fiber.

17:42  Nutrient density score.  Most peoples’ diets fall short of supplying us with the daily values of all the essential nutrients.  And the RDA should really be thought of as the minimum rather than as the optimal levels.  Dr. Ballantyne has developed this system that includes 33 nutrients in the calculation weighed equally, compared to the daily value, and considering the calric content of the food.

 

 



Dr. Sarah Ballantyne was previously known as the PaleoMom and is the best selling author of five books, including her new book, Nutrivore: The Radical New Science for Getting the Nutrients You Need from the Food You EatIn this book, Sarah creates educational resources to help people improve their day-to-day diet and lifestyle choices, empowered and informed by the most current evidence-based scientific research. With Nutrivore, Dr. Sarah has created a positive and inclusive approach to dietary guidance, based in science and devoid of dogma, using nutrient density and sufficiency as its basic principles: Nourishment, not judgment. Her new website is Nutrivore.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz: Hi this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com. Thanks for joining me and let’s jump into the podcast. Hello, Rational Wellness Podcasters.

I’m excited today that we’ll be speaking with Dr. Sarah Ballantyne about her new best selling book, Nutrivore. Nutrivore’s subtitle is the radical new science for getting the nutrients you need from the food you eat.  In this book, Dr. Sarah creates educational resources to help people improve their day to day diet and lifestyle choices, empowered and informed by the most current evidence based scientific research. With [00:01:00] Nutrivore, Dr. Sarah has created a positive and inclusive approach to dietary guidance based in science.  And this is the Rational Wellness podcast, so we love science and devoid of dogma, using nutrient density and sufficiency as its basic principles. Nourishment, not judgment. While there’s a lot of great valuable information in this book, one thing that I found particularly helpful was the Valuable Vitamins Cheat Sheet, which we can refer to.  Dr. Ballantyne, thank you so much for joining us.

Dr. Ballantyne: Oh, thank you so much for having me.

Dr. Weitz: You say Nutrivore in your book is not a diet, however, you were previously known as the Paleo Mom, so in this book, your description of a healthy diet in this book sounds more like a Mediterranean diet, so, it sounds like you changed your [00:02:00] approach, did you have to file divorce papers from the paleo community?

Dr. Ballantyne: I’m, I’m pretty sure it’s still enough through legal action that I’m not allowed to say anything. No, in all seriousness, you know, I think, my transition from Paleo to Nutrivore has been a very iterative process. I can’t say that there was one moment where I went, Oh, I think I’m wrong about some things.  I think this entire community is wrong about some things. I think there is a more diverse diet that we can be embracing that actually will be more health promoting, but also, have better coverage in terms of supplying all of the nutrients that our bodies need. It really, the research started, I think it was 2014 or 2015, I started doing, researching for a book on the gut microbiome, that still has not been published, but it was that research of really trying to understand how different foods impact the composition of the bacterial community that lives in our guts. That was the beginning of me going, oh wait a minute, legumes are really phenomenally health promoting. They’re the most nutrient dense, starchy foods. They have vitamins and minerals that, make them very valuable. They’re really great sources of polyphenols, and I don’t think we think of legumes as, being particularly great sources of polyphenols.  And the more that I did this research, the more I really questioned a lot of the dietary dogma that I had bought into.  And as the research and reading the science really, like, opened up my eyes, I started to realize that I had some disordered eating patterns that I had learned through the Paleo community as well.  So I had this personal journey behind the scenes of addressing my own food fears and expanding my own diet as I was undergoing this professional journey right out in the open for everyone to see as I kept going, excuse me, I think, I think maybe we’re wrong about lentils. I think maybe we’re wrong about corn.  I think maybe we’re wrong about oats. And the, the more foods that I, that are not considered paleo, that I really started to, like, change my mind on, the more it became obvious that it was time for me to move on, and, and build something new, and that’s what Nutrivore is.  

Dr. Weitz: So, you have a chapter in, or a section in your book where you talk about the myth of plant toxins, and, you know, one of the big knocks against legumes and lentils, things like that, are that, and this is a argument that paleo advocates often utilize, that lectins, that these foods like legumes contain lectins and phytates and what are called anti-nutrients or plant toxins and these are one of the main reasons why we want to avoid grains and beans.

Dr. Ballantyne: Yeah, so I actually this is, there was a huge conversation behind the scenes with my editor and the team at Simon Schuster about this chapter. So chapter 10 is a myth busting chapter and it kind of has something for everybody in there because it also talks about, whether or not, right, the myths about animal foods being bad for us, which is not true.  There’s a lot of seafood myths that I bust, a lot of myths about food quality, talking about, you know, olive oil and, organic foods as well.  It was really important to me to include a section on plant toxins, because that was the world that I used to, to, those were the circles I used to be in. And I had sort of learned that way of thinking from very prominent scientists names that we’re all familiar with if, if we’ve heard about Lectins and Phytates and Oxalates.

Dr. Weitz:  We might call this the anti-Gundry section.

Dr. Ballantyne: That could be. And as you dig into the science, I mean there’s, there’s a couple of different layers here. So the first layer is that yes, like sometimes the isolated compound in a food, like in, in a lab, it, in, when scientists are validating these compounds, they’re looking at them for potential use in pharmaceutical industries, typically where these scientific studies come from.  And I used to do this type of research. So like, I’m very, very familiar with how these experiments are designed and the different types of techniques that are used. So you take this, this compound that’s isolated from something. And you, first of all, you put it on some cells, and you see like, what do those cells do?  Does it change the proteins those cells are making, right? Like, that’s a really interesting way to understand that compound. Does it have use in a pharmaceutical industry somehow? And then the next kind of step you do to understand what this compound does is you, use it in animal models. So for example, there are some specific, plant toxins [00:07:00] that in animal models of colitis, when you administer just that one compound, you get increased inflammation.  That sounds really scary. That is not, that scientific study is not there to tell us to not eat the whole food. It’s there to help understand whether or not there’s pharmaceutical applications for that one specific compound in the food. And so we need to be understanding those studies within that bigger picture of how does the whole food, because a food is thousands of different chemical compounds, you know, maybe dozens of different nutrients. How does the whole food affect our entire biology?  Because every food will have something that you could isolate and concentrate and put in some, you know, high doses in an animal and go, okay, here’s a negative impact to one biological system. That is actually where a lot of pharmaceutical discovery has, has come from. A lot of cancer drugs come from exactly that process, [00:08:00] but that doesn’t help us understand the whole food.

And so my, my realization of this sort of logical fallacy of like, just because a food has a compound in it that is harmful to one biological system or one specific circumstance, we can’t judge the whole food based on that compound. And that was one of my main, um you know, uncomfortable realizations that I had been thinking about nutritional sciences in this way that is incorrect. And that really drove me to go back to the research and go, okay, so now let’s actually look at studies showing, like looking at whole legumes and not just looking at phytohemagglutinin as a, as an isolated compound. Let’s see how, in animal models, in humans, in intervention studies, where you give a group of humans and you have them eat more legumes.  Let’s look at these studies. And what you see is. the fiber types, the polyphenols, the very high legumes are the the most nutrient dense starchy foods on [00:09:00] average. They’re very rich in vitamins including folate which is one of the most common nutrient shortfalls in the standard American diet. So legumes tend to be some of our best food sources of folate.  Very very mineral rich. You start to see that the that all of the benefit we’re getting from those nutrients, the way that that fiber impacts the gut microbiome, all of that constellation of beneficial effects that we’re getting from eating the whole food completely suppress any potential negative impact from that one compound that in isolation is not great for us.

We’re not eating that compound in isolation, we’re eating the whole legume. And so that is a major sort of difference in how I have changed my view of research. Another big thing that really shifted for me over the last seven or eight years is putting more value in meta analyses. Now, a scientist will always say, right, that the most rigorous scientific [00:10:00] evidence is meta analyses, systematic reviews, umbrella reviews, right?  Like these are the studies, that pool together data for many, many, many studies. So they have a bigger data set. So they have more statistical power, and they incorporate a step of evaluating studies for bias. And so they, they actually have a step for evaluating a study’s quality before they incorporate the data into their giant data set.  And then they typically include a, now let’s also look at all of these, animal model studies, cell culture studies that help explain why this is the average effect we’re seeing. And that is another change that I’ve really made over the last, you know, several years in how I am understanding food is instead of looking at that one study that used phytohemagglutinin in an animal model of colitis, right, and showed increased inflammation.  I’m looking at the systematic reviews that look at all of the different [00:11:00] intervention studies where they take a group of people and have them eat more legumes and then measure various health outcomes, look at it, reducing risk of cardiovascular disease, type 2 diabetes, how it can cause weight loss in people with overweight or obesity how it can reduce risk of certain types of cancer, like looking at that big, big picture in these huge studies that are pooling together data from 20, 30, 300 different studies.  So they have really, really high statistical power. So it’s also a more rigorous approach, and one that really values scientific consensus. And so I included that in Chapter 10 because, I know my followers have kind of watched this whole journey, right? They’ve, they’ve seen all the little bits and pieces as I start to piece this together and really question a lot of the diet dogma that I held to be true.  But it’s also there for the, for the people who are not following that closely to help them understand my transition to a permissive dietary [00:12:00] structure where we can make room in a healthy diet for any food.

Dr. Weitz: That’s great. I generally agree with your overall dietary approach. However, when it comes to the research, it continues to be problematic.  And even if you’re looking at meta analyses, unfortunately, most of the dietary studies are not randomized controlled trials where they give people certain foods and they’re basically just asking people to fill out these food frequency questionnaires, which are so inaccurate. And that makes it difficult, I think, to talk about the real science when it comes to food.  You can’t just take a group of people and just give them, make sure they’re eating legumes, you know.

Dr. Ballantyne: So let’s drill down on that because I think, you know, your point of large perspective studies is really important. Like, I think that is a really important thing to sort of explain to your listeners here.  So perspective studies, or they can be retrospective too, [00:13:00] but these are the studies where we take, I don’t know, 20,000 people and we follow them for 10 years, right? Things like, these are things like, the NHANES study, Framingham, right? There’s these huge, huge cohort studies.

Dr. Weitz: Right, but none of these are control trials where you’re actually giving them food.  So you really have no idea what they’re eating. And then they’re filling out these food frequency questionnaires, sometimes asking them, what did you eat in the last month?  Sometimes in the last year?  And, you know, the recall is so sketchy.

Dr. Ballantyne: Absolutely. So different cohorts have different levels of, sort of trust in their diet recalls.  So for example, the NHANES cohort, their diet recalls are what did you eat over the last two days? And they take that as various snapshots over time. So that is considered a dataset that is much more reliable in terms of, like, actually reflecting what people eat, but also, Our memory is fallible.  We do not want to admit to eating certain things when we’re [00:14:00] being given a survey. And all of those studies are correlative, right? So they tell us that there may be an association, but we have no way of knowing from those types of studies if that association is causative. Did that group of people have lower cardiovascular disease risk because they eat fewer legumes or more legumes, or is it because of this constellation of factors, because that’s the other thing that we see in these types of studies is something called healthy user bias.

So this is where somebody who is eating more plant foods, less, I mean this is a big problem in all of the studies showing that red meat is problematic. It’s a big problem. It’s like a classic example of healthy user bias because red meat has been demonized for so long that people who don’t eat very much red meat tend to eat more fruits and vegetables, they tend to be more active, they tend to also have higher socioeconomic status, so they have social determinants of health working in their favor.  They tend to be female, who also we just get less cardiovascular disease.  And so it’s really hard when you have a lot of different things stacking in these correlative studies to be able to separate out, okay, but how much of this is that these people are eating more legumes? And how much of it is all of the other things that go along with that person who eats more legumes?

And that is, This is absolutely a challenge in nutritional sciences research, and one of the reasons why I never only rely on prospective studies in my interpretation of nutritional sciences. So fortunately for us, we are getting more randomized control. They’re not blind, because you can’t blind somebody from the diet they’re eating, typically.  There’s a few studies where they’ll be like, here’s a muffin and you don’t know if that’s the muffin that has the extra fiber in it or not, right? There are some studies that they can figure out blind, but overall diet studies, we can’t, but we are getting more studies where they take one group of people and say, keep doing what you’re doing, and they take another group of people and they have them work with a dietitian, they work with a, you know, work with a health coach, and they have a dietary structure for [00:16:00] them to follow.

And we’re getting more and more of those studies that we can then go, okay, so we have the intervention study that reinforces what we see in this big observational one that can’t establish causality. And then we can also look at The nutrient difference in, in what these people are eating and look at what we know about how those nutrients impact these biological systems and make a strong case for that being the causal mechanism here as well.  So it is very much about, yes, I absolutely agree that not putting too much weight into an observational study because it cannot establish causality. But taking that as our indication that here’s something to drill down further on understanding healthy user bias and, and how that impacts statistical analyses, but also then we can start layering on, other, other evidence.  And I think we do have a Fortunately, a growing body of intervention clinical trials, randomized but not blind, as well as animal [00:17:00] models that can help to drill down on the biochemical mechanisms behind the benefits.

Dr. Weitz: And let’s get back to the scientific information that you’re adding to our body of knowledge, which is the nutrient density of foods.  So tell us why higher nutrient density is so important and then how do we measure it?

Dr. Ballantyne: Yeah. So, I think that the background piece of information here is that most people’s diets fall short of actually supplying us with even the daily values of all of the essential nutrients, which, 

Dr. Weitz:  Which we know are very, very under, you know, very limited and most people would benefit from having more than the RDA.

Dr. Ballantyne: Absolutely correct. So, so we’re falling short of the RDA. Okay. And there’s some indication that the RDAs are still maybe not optimized, right? Like, they really need to be thought of as a minimum for most nutrients. I think they’re probably in the range for some. And [00:18:00] so there’s four essential nutrients for which 90 percent of Americans are not hitting the daily value, ever.  There’s ten essential nutrients for which half don’t of Americans are more or not hitting the daily value. But even when you, there’s a lot of different studies that will analyze diets that either look at meal plans from, you know, cookbooks or whatever, or they’ll look at people following that diet and look at what they’re actually eating.  And they’ll analyze the diets for nutrients and show that even people who are following diets anticipating that those are healthier ways to eat. Uh, each diet has a collection of nutrients that are a lot harder to get. And so there is a proportion of people who are not meeting the daily values of those nutrients.  And, I mean, government dietary guidelines aren’t off the hook here either. Even the dietary guidelines for Americans has a collection of about five nutrients that people aren’t getting enough of even if you follow the guidelines perfectly. So this is kind of a thing that is across dietary guidelines.

Dr. Weitz: Not to mention that there’s thousands of phytonutrients for which we have no guidelines at all and nobody has aren’t even calculated.

Dr. Ballantyne: Ew, I’m so glad you brought that up. I mean, we have, there’s like 10 ish thousand phytonutrients of which we really understand a few hundred. We know the more of them we consume, the healthier we are on average.  We know the biochemical mechanisms, there are very strong antioxidants, they tend to be anti inflammatory. Different phytonutrients localize in different areas of the body, they interact with different pathways, so they have a wide range of different benefits. So, we want. to be consuming a wide range of phytonutrients.  And there’s no daily value for phytonutrients. There’s probably enough data to actually establish one for polyphenols, but that hasn’t been done because we don’t get daily values for non essential nutrients. But I think you and I are on the same page that maybe phytonutrients could be labeled as essential just because they’re so important.

So we are, we’re in a situation where even people who are really intentional about their [00:20:00] food choices because We don’t learn this, right? We don’t learn in school, but also in dietary templates. When you are picking up a diet book at the store, you’re typically learning about what to not eat or how to measure the things that you eat.  You’re typically not learning about nutrients and what they do in the body and which foods contain what nutrients and how to choose foods from different groups so that you’re getting the full range of nutrients that your body needs. And that is what I am building with Nutrivore. And so that includes identifying nutrient dense foods and focusing on them because we’re trying to fill that gap.

So typically, our intake of these nutrients is high enough that we don’t have a disease of malnutrition, right? We don’t have scurvy. We’re getting enough vitamin C to not have scurvy, but we’re still falling short of hitting our daily value and vitamin C is definitely an example of a nutrient for which we Getting a lot higher than the daily value has been shown to have a lot of benefits for, for various situations.  [00:21:00] So, we’re in that weird ray of like, okay, it’s not so low that we’re like, I’m really, really sick, but not getting enough vitamin C is increasing risk of mental health challenges, increasing risk of cardiovascular disease. It’s having a negative impact on our health. So the best way to fill not just that vitamin C gap, but all of the different gaps that we have is identifying nutrient dense foods and being intentional about adding them to our diets.  So that is again, one of the tools that I am creating in my book, A Nutrivore.

Dr. Weitz: I’m curious as to how you come up with this, nutrient density score, for example, are all nutrients equal weighted? Are some more important than others, you know, how, how much is considered a good amount?

Dr. Ballantyne: Oh, I, that’s okay.  I’m going to nerd out about nutrient density calculation math with you. I think you, we’ve got [00:22:00] another three hours, I hope. So, I created something called the Nutrivore score, which is a measurement of nutrient density, which is scientifically defined. This is the consensus definition as total nutrients per calorie.  The definition of nutrient density, like it, Nutrient density calculations have an interesting history. So a nutrient dense food, that term was first coined in the 70s and it was defined as any food with a substantial amount of nutrients per serving. Substantial was not like specified any more than that.  You’re like, what does that mean? And so, I was someone who was alive in the 70s, 80s, and 90s. I remember labels and how that was like the beginning of like the health aura and the like healthification of labels but not the product, right? That led to a lot of challenges. And what ended up happening in the 70s, 80s and 90s was the demonization of foods as bad because they had high [00:23:00] fat content, like avocados, nuts and seeds, right?  These foods that we now recognize are really like important heart healthy fats. Those foods got demonized for having high fat content. But a sugary fruit punch could say a good source of vitamin C on the label if it had 10 percent of the daily value per glass. And so in the early 2000s, that definition was updated to significant amounts of nutrients per calorie.  Because we were in a situation, we’re still at a situation, where there’s no shortage of calories in the food supply, but there is a shortage of nutrients in the food supply. So we need to understand how to get more nutrients per calorie, not more servings of foods. And at the same time, scientists are working on different nutrient density scores.  So there’s a few dozen of them that have been created over time, none of which have been adopted by any institute or agency. My initial intention when I was first building the Nutrivore website and working on the the early foundational content.  In preparation for writing the book was I’m going to go through all this research and figure out which one’s the [00:24:00] closest to being ready for prime time, which one is almost there.  And I’m just going to use whichever is the best one in the science. I spent three months reading every single nutrient profiling paper out there. And I kept hitting, well, why are you guys doing that? I kept hitting these moments where I was like, That makes no sense. So, couple of the challenges, and you identified a few right in the question.  So, one of the biggest like, like pitfalls that I see happening in nutrient profiling right now is scientists are trying to figure out which nutrients to include in the calculation so that the score at the end aligns with the healthy eating index, which is a measurement of how well someone’s diet follows the USDA dietary guidelines for Americans.

Uh, it’s kind of like retrofitting the score for the guidelines that already exist. I think that’s the opposite of the right way to go about it. I think we should be figuring out how to understand the food and then seeing what that tells us about maybe some edits to the next day. The guidelines are [00:25:00] updated every five years.  It would not be a big deal to edit them again and go, hey, now we know these foods are more nutritionally important, right? That, that’s, there’s, that should be something that can happen. And then there’s this idea of like penalizing foods for containing things like added sugars or sodium or saturated fats or cholesterol.  And then there’s this idea of, like weighting certain nutrients. That’s all kind of happening right now in the scientific literature. So like the Food Compass is sort of well known because it keeps making the news for having such a high score for Lucky Charms cereal. It is not ready for primetime either, although I think it’s probably the most interesting out of the ones that are in development right now.

Dr. Weitz: We have to look at who’s funding all this food science.

Dr. Ballantyne: They’re weighting food attributes, they call them, in a way that is a very like plant based diet lean. And the fact of the matter is you don’t need to weigh certain nutrients more [00:26:00] heavily than others to get to the end of plants have lots of nutrients per calorie.  Like that’s, that’s an easy conclusion. All of these different scores come up with that result. That’s not something you need to put in the math, but that’s what a lot of the direct to consumer, right? That’s what Furman’s ANDI score does as well. It doesn’t include nutrients that are mostly found in animal foods but it includes a lot of nutrients that are only found in plant foods.  And you end up with a system that makes animal foods look terrible and plant foods look great. So with that being, my starting place, like that’s okay. This is, this is the field of science. What that, this is what I have to work with here. I, I, it was a really obvious like algorithmic choice for me.

So the Nutrivore score is algorithmically identical to something called the Nutri Rich Foods Index. So it’s simply a sum of amount of nutrient divided by daily value of nutrient, and then that sum is divided by the energy density of the food. There’s no weighting certain [00:27:00] nutrients more heavily than others.  I think you end up in a situation where you, you bias foods when you start doing that. And also, you could take the approach of, I’m going to weight the nutrients that people are more likely to be deficient in. more in this, like, I’m gonna, like, let’s say it’s like folate, vitamin E, vitamin A, vitamin D. I’m going to give those more weight.  Magnesium, vitamin D. Magnesium, vitamin C. But, you know what happens when you do that and you create an entire system on that, is you overcompensate, right? So people start choosing those foods because they have these higher scores and now they’re missing out on the nutrients that are not given as much weight in the calculation.

So that just felt like that the future proofing of the score is to not actually give these nutrients more weight, but to include as many different nutrients as I have enough data that makes sense to. So the Nutrivore score includes 33 nutrients in the calculation and weight them all equally and make sure that I have representation in these [00:28:00] nutrients of nutrients that are inherent to plant foods, that those are the only source, but also nutrients that are inherent to animal foods, that that’s the only source, so that we’re not automatically putting in a plant based diet bias into the score, and then do all of the math blind, and then just see what it tells me.

And so the NutriScore doesn’t, like, all the nutrients are weighted the same. There’s no, it’s really too complex of a system to be able to do corrections for competitive binding or nutrient synergy because it has to do with everything you eat at a meal and not just what’s in one food, like, as soon as you put salad dressing on your salad, you’re going to absorb more vitamin K and beta carotene, it’s way, it’s, it’s way too complex, and it doesn’t really tell us about the food.  So it’s just a very simple calculation. And it’s the context of like how much is nutrient is versus how much we need. It’s the daily value. Thank you. Yes, the daily values might be an underestimate, but in terms of the math, that doesn’t really matter, because what it is doing is it is basically saying, [00:29:00] this thing we need 100, 100 milligrams of so 200 milligrams in this food is amazing, right?

That’s so great. This thing we need 10 nanograms of, I don’t think there’s anything that’s measured in nanograms, 10 micrograms of, okay, so we’re gonna, we’re gonna, you know, basically it’s, it’s a way of correcting for how much we need. So it doesn’t really matter that they’re, they might be a little bit off.

It’s ballpark is, is good enough in that math. Uh, and then yeah. And then there’s no normalization. There’s no weighing for different food groups, which some of these scores do. They’ll just say, okay, we’ll give the top food in every, in every group. We’ll get a hundred. So then all of a sudden you’re making, you’re making like kale look the same as like whole wheat bread because they’re the tops in their groups, which is, I think also silly.  So it just keeps it very, very simple. It’s a straight up calculation. Yeah. The thing that’s special about it is how much data is in the calculation and that’s why it gives us such a complete picture of the nutrient density of foods.

Dr. Weitz: I make a prediction you’re probably not going to get a huge grant from [00:30:00] Kellogg’s for your program.

Dr. Ballantyne: No, but you know what, a grant would be a grant. Would it be a grant? As long, as long as I can maintain my independence. Yeah, no chance, chances, chances are good. Uh, the Kellogg’s cereal tends, tends not to, even fortified tends, tends not to have Amazing nutrients. 

Dr. Weitz: You know that whole fortification thing, it’s interesting.  There’s an example of where you’re weighting certain nutrients and how we think we’re making people healthier. Just take iodine as an example. So we had all these millions of people suffering from goiter because they had low iodine. And so we add iodine fortification by adding it to the salt and we have this huge decrease in the number of people with goiter.  And we have this huge increase in the number of people with autoimmune thyroid Hashimoto’s. So, you know, it’s being applauded for years now as this great example of how fortification is so beneficial, but [00:31:00] we just traded one disease for another.

Dr. Ballantyne: I mean, potentially, as somebody with Hashimoto’s thyroiditis very, very personal one there.

Dr. Weitz: You can put me in that camp too. 

Dr. Ballantyne: Yeah, I know. It’s like worst initiation ritual ever to get into that club, right? But, but yeah, I think, you know, that’s, so fortification is fascinating to me. Let’s go on this tangent. Because, because, you know, it really has very limited success stories. So even if you, even if you bought into that very simple narrative of we got a 74 percent reduction in, in goiter.  And even if you wanted to say Hashimoto’s thyroiditis is much more complex than iodine excess. And so let’s, let’s not count that as, as like coming off of the success story. I think there’s a lot of nuance here and probably Of course. 

Dr. Weitz: Yeah. I was oversimplifying for sure.

Dr. Ballantyne: And then we’ve got iron fortification, and that has caused, if I remember correctly, it’s like 30 or 40 percent reduction in iron deficiency anemia, [00:32:00] and then folic acid fortification has pretty, like, impressively reduced risk of neural tube defects.  Those are the three success stories of fortification, right? So we’ve got three success stories, we fortify with a lot more nutrients than just those three, right? Like pretty much all the B vitamins except B12 are in a fortification. Okay, well not B7 either. All of the, the, the B vitamins that we were known about in the 40s.  And then we’ve got vitamin D, but not, not in that many. That’s mostly in, dairy products that are geared at kids and not as much in dairy products that are geared as adults. I think it’s, it’s, It’s kind of surprising how little of an effect fortification has had on, well, no effect, on like the really big You know, health conditions that are a major burden on society that can completely take away your quality of life, that have really high morbidity and [00:33:00] mortality rates, right?  Like cardiovascular disease and type 2 diabetes and cancer. You can’t see a signal from fortification reflected in those health outcomes, nor can you from multivitamins. Which is fascinating to me, and it really to me reinforces the importance of getting at least most of our nutrients from whole foods.

Not that I’m anti supplement, there’s definitely a time and a place. Like, I take so much vitamin D to keep my levels normal, right? Like, I’m definitely not anti supplement, but I think that if you think of fortification as a supplement, right? It’s the same forms that are in a multivitamin, generally. It really, you see the value of a food first approach and then, you know, individualized supplementation as a second layer rather than supplementing the entire food supply.

Dr. Weitz: Right. So, since you’ve been calculating the nutrient density of so many foods, tell us about some of the biggest surprises that you’ve discovered, which [00:34:00] you talk about in your book.

Dr. Ballantyne: Yeah, there have been,

Dr. Weitz: by the way, warning, warning, … Sarah is about to bust some of the food myths and functional medicine practitioners are not going to be happy.

Dr. Ballantyne: Yes. Uh, thank you for the, like rolling out the, what is the opposite of the red carpet for the answer to this question. So I think the, there’ve been a lot of surprises now, my take a sort of high level view to this question before I share like the most nutrient dense food, which nobody would have ever guessed in a million years.  I think the best way to use the Nutrivore score is to identify simple swaps or additions in a meal that don’t take away from like your enjoyment of the meal, but will add a lot of nutrition to the meal. So like a really easy example would be like if you’re making a pasta dish, like swapping out regular pasta for whole grain pasta will add some nutrients, but then if you swap that out for like a lentil or chickpea based pasta, so you’re [00:35:00] gonna, you’re gonna double your nutrient density going from like plain whole wheat, you’re going to about quadruple it going up to like a lentil or chickpea based pasta.

And that’s all you did. But then maybe you also identified a simple addition and you added some sliced mushrooms to your sauce or some basil or some garlic. Probably added a lot of flavor to the sauce as well, but then you added a lot of nutrition and Your pasta dish is probably just as great. So, as a practical tool, I think that’s the best way to use the Nutri Force score.  My favorite, like, nerding out surprise moments, are the foods that have reputations for being nutritionally pointless, that get a redemption arc, that through the Nutri Force score calculation, my favorite example of this is iceberg lettuce, which has more nutrients per calorie than celery, or, which we put up on this pedestal.  or Cucumber or Artichoke. It actually has slightly more nutrients per calorie than Sockeye Salmon. 

Dr. Weitz: Does celery juice cure all ails?

Dr. Ballantyne: Waiting for the scientific study to show that one. So far, [00:36:00] so far so far lacking. Although celery does have some really interesting polyphenols, but you’re getting that from celery in any form, it doesn’t have to be juiced.  So that’s my favorite way to use the Nutri Score. Is to kind of say, like, look at the value of iceberg lettuce, look at the value of watermelon or potatoes. Like, foods that people kind of love to dunk on. But there’s also been a lot of, you know, Just like, who, okay, who could have known that the single most nutrient dense food was canned clam liquid?  Like, that is not something, if you had told me, like, here’s, here’s your data set of 8, 000 foods, guess, what, what are you gonna guess? And I would have guessed liver, maybe, Or maybe like a Leafy Green, like Watercress, and Watercress and Liver are both, like, way up there. But the single most nutrient dense food is canned clam liquid.  And here’s how the math works out. Like, here’s, here’s how that happens. I feel like that needs, because I do not want to start a drinking clam juice story. Trend That is not what we’re trying to do here. . I wanna say why we’re run clam

Dr. Weitz: juice in every [00:37:00] grocery store. .

Dr. Ballantyne: I mean, if you are going to incorporate, make sure to go up on totally paper

Dr. Weitz: and clam juice.

Dr. Ballantyne: Clam juice. Empty, empty shelves. Make sure to look for a low sodium option if this is something that you want to incorporate. You don’t have to, though. I think that’s the other liberating thing about the new, the 

Dr. Weitz: What the hell is clam juice anyway?

Dr. Ballantyne: So it is literally the liquid that, like, clams are cooked in.  So, so you can either get it from, like, it is the liquid when you drain a can of clams, or you can buy it separately because it’s used as an ingredient in linguine with clam sauce in clam chowder. It’s used as a cocktail ingredient. So it has some like traditional like food uses as well. But yeah, it is the liquid that clams are cooked in typically pressure cooked in.

Dr. Weitz: So there is some I think you should change the name to clam broth. It’ll sell like crazy.

Dr. Ballantyne: Yes. Clam juice does kind of sound like you squeezed the clams. That’s, I’m pretty sure there’s no squeezing [00:38:00] step. It’s just Heating them in liquid, then doing something really cool with the clams, and then selling the liquid because it has a lot of flavor.  Clam Bisque, I mean, I guess you could think of it as, yeah, but it’s unseasoned. So, there’s a lot of nutrients that are in the clams that ends up, you know, that are water soluble that end up in the liquid. So the reason why canned clam liquid or clam juice is the top most nutrient dense food, and this is true for all of the most nutrient dense foods, it’s very very low energy density.  So when you divide by a very small number, you get a much bigger number. So a food that has a very low energy density So canned clam liquid is five calories per cup. When you have something that’s that low energy density, it doesn’t have to have a ton of nutrition to have high nutrients per calorie.  So remember, nutrient density is nutrients per calorie, not per serving or per hundred grams. So, when you have something that’s super low energy density, doesn’t need to have a ton of nutrition. And canned clam liquid, [00:39:00] has some impressive nutrition. It has 500 percent of the daily value of vitamin B12 in a one cup serving, like, which is just huge.  And it also has some potassium, some other minerals, it’s, you know, it’s got some other B vitamins, it’s got some protein. So it has an impressive amount of nutrition. for that five calories. That’s how the math works out for it to be the top. But is it going to contribute the most, like, nutrients to your diet?

No, that’s going to be a food like the actual clams, right, or oysters, or liver, or those like really nutrient dense leafy greens like kale and watercress and rainbow chard. Those are all the foods that are going to contribute a lot more to your diet. like absolute nutrition, which is why I never recommend only using the NutriVerse score to choose our foods, that we, it’s fascinating, it tells us a lot about a food, but it’s not the only information that we want to be considering when we’re putting together our plates, because then we’re going to end up with a diet where we’re just eating, Clam juice and watercress all day and that’s not going to be [00:40:00] nutritionally beneficial.  But other foods that have that like really low energy density that end up with really high NutriVore scores are not as alarming as clam juice. Like coffee is way up there. You know, it’s, it’s one of the top most nutrient dense foods because it’s packed with polyphenols, actually has some B vitamins as well.  but also one or two calories per cup. A lot of leafy greens make the cut. Same, same thing, right? Not very high nutrient density, but for each calorie, tons of nutrition.

Dr. Weitz: Interesting. You also break the myth about healthy fats and you state in your book, that healthier fats include olive oil.  Avocado oil, which most functional medicine practitioners agree with, and soybean oil, canola oil, corn oil, and sunflower oil, which many in the functional medicine community do not agree with.

Dr. Ballantyne: Yeah, this was [00:41:00] one of I want you to just imagine me coming from a place where I was very anti vegetable oils in the past and really reading in the science and falling down this rabbit hole of scientific studies for a few weeks, because I had such a hard time wrapping my head around this.  So I, I want to, like, like, I want to preface my answer to this question by, yep, I, my inner child had a temper tantrum as I was reading these studies. I had a really hard time. Being open to this research. It was, it was really challenging, and, and it’s because We’ve got such a strong mechanism in place for understanding high omega 6 polyunsaturated fats in relation to omega 3 polyunsaturated fats and how those should be inflammatory, right?

We, we just have such a wealth of scientific evidence showing that, These fats in the cell membrane are used as substrate and what, which one you have will [00:42:00] determine which you know, paracrine and autocrine signaling molecules are made. We know that if omega 6 is there, we get inflammatory signals.

We know if omega 3 is there, we get either anti inflammatory or anti inflammatory. Only mildly inflammatory signals. Like, we have, we have it all mapped out. We know, we know all the biochemical mechanisms. And yet, when you give humans canola oil, or corn oil, or soybean oil, not only does it lower their cardiovascular disease risk factors, like, like, seeing lower serum cholesterol, is only exciting if you also see lower cardiovascular disease risk, which we do.

We see lower all cause mortality, a general indicator of health and longevity. And, what’s fascinating is studies that have actually compared canola oil head to head with olive oil intervention trials have shown They’re both equally as good for cardiovascular disease risk, and they work through different mechanisms, so actually, we would be, we would be best off if we were incorporating [00:43:00] both into our diets, which is mind blowing, because it tells us that there is some regulation of these paracrine and autocrine signaling molecules beyond substrate bioavailability.

but we don’t know what it is. And that is, fascinating. This is definitely a, science has really shifted in the last five years. We’ve got now a really good body of scientific evidence showing benefits to vegetable oils. I still put olive oil on a pedestal. I still think olive oil is, is the king of oils.

You just can’t, you just can’t, like the polyphenols, the triterpenes, it’s got so much good stuff in it. You, you really can’t, I don’t, I don’t think you can beat olive oil, but it shows that these more affordable. oil options are beneficial. Not as good as olive oil, but for somebody on a budget, you know, still beneficial.

And I think what’s, what’s so important in following that science is, again, right, the difference between how we understood it when it was in animal models, [00:44:00] and cell culture models, versus now how we understand it in humans, and the fact that it reveals an important something different in our biochemistry that we still need to understand, but we’ve got these intervention trials that make the result very, very clear.

Dr. Weitz: I just want to apologize to the listeners for this gardener who’s right outside my window who seems like he’s never gonna stop with his lawn blower or whatever it is. So I wanted to push back just a little bit because I do think that a percentage of these studies that have shown that there’s a decreased cardiovascular risk with soybean oil and some of these other polyunsaturated oils is because they’re comparing saturated fat with substituting a soybean oil or something like that and That’s not necessarily substituting an omega 6 versus omega 3 or, you [00:45:00] know, an overall different type of, you know, there aren’t too many studies that, you mentioned one, but there aren’t too many studies that are really comparing olive oil versus soybean oil.  uh, saturated fats versus polyunsaturated fats and the polyunsaturated fats having some benefit potentially.

Dr. Ballantyne: Yes, I, so I think that’s a great point. So I think, the, the broader point is when we switch to something, right, There’s two parts of the equation. There is whether or not the thing we’re now eating, what its health effects are, and what is the thing that we swapped it out for.  Right. So absolutely correct. The studies that show benefits to vegetable oils are the studies that show swapping out butter or margarine for vegetable oils. So swapping out a saturated fat, whether that’s a natural saturated fat or a man made saturated fat, which what fully hydrogenated vegetable oils and margarine are.

For an [00:46:00] unsaturated fat. I still think that’s very fascinating and I still think that it makes a strong case for benefits of vegetable oil, but there are now more, more studies that are comparing vegetables to olive oil. There’s one that I cite in the book that compared If I remember correctly, it compared, olive oil, corn oil, sunflower oil, and I think canola was in there, and it looked at all cause mortality, again, sort of a broad indicator of health and longevity.

And, I think, like, nobody is surprised, it showed olive oil, right, high oleic uh, acid, right, a omega 9, a monounsaturated fatty acid, extremely rigorously shown to reduce cardiovascular disease risk, right? So, it showed olive oil was, was, was the king, was definitely beneficial but then it showed still reductions in all cause mortality from other vegetable oils and increases in all cause mortality from margarine and butter.

So your [00:47:00] zero was not having these things, right? And I think, I think there is a good enough body of scientific literature, for example, showing in humans that we don’t see vegetable oil consumption increasing C reactive protein or TNF Tumor Necrosis Factor Alpha, or Interleukin 6, like these markers of inflammation.

I think there is enough information to say solidly, again, olive oil, avocado oil, I don’t think you could compete with them because those monounsaturated fats are so beneficial. But I think we can take a step back for sure from saying that vegetable oils are problematic. I don’t, science does not support saying that they’re increasing cardiovascular disease risk or that they’re inflammatory.

Dr. Weitz: Just to play devil’s advocate one more time, I hope you don’t mind, is, there was the Minnesota study, which was one of the few dietary studies where they actually had people staying at this mental institution and they were able to control everything they ate so they know accurately what they really ate.  And it turns out that when they [00:48:00] substituted, omega 6 oils for saturated fats, While there was a potential reduction in cardiovascular disease, all cause mortality actually increased in those eating the vegetable oils, and the conclusion seemed to be that there was an increase in cancer, which people attributed to some sort of increase in inflammation.

Dr. Ballantyne: I, I’d be very interested, I’m not super familiar with that study, so I, I don’t. 

Dr. Weitz: Remember the studies in the 60s, and the Minnesota was. Oh, the Minnesota starvation. Published, and they went. It was the Minnesota

Dr. Ballantyne: starvation experiment, was also part of it.

Dr. Weitz: I don’t know. This was like in a mental institution and they hadn’t published it.  And then just like in the last, I don’t know, 10, 15 years, they published it. And so.

Dr. Ballantyne: Yeah. I mean, I I don’t want to, to speculate on the quality of that study, having not, not read it. I, my, my, my little alarm bells go up as soon as you say the data was published 30 or 40 years later, because we don’t actually know what the methodology [00:49:00] was in that case.  The people who probably, We’re taking, right, taking notes on that data may no longer be with us. So I do have little like my little skeptic are dark up, but I don’t want to comment because I’m, I’m not familiar. That’s

Dr. Weitz: okay. Since, since you’re breaking myths, you also said something about olive oil, which I think people need to hear.  I talked to so many people who are like, I won’t cook with olive oil because it’s, it’s going to become rancid. It’s going to be damaged by the heat. Can you explain what the deal is and is it okay to fry my eggs in olive oil?

Dr. Ballantyne: It is absolutely fine to cook with olive oil. They’ve done studies where they sit, they heat olive oil for like 24 hours and measure how much of the fats get oxidized in that time and show olive oil is actually incredibly heat stable.  The higher the quality of olive oil, typically the better, even though it has a lower smoking point. So we do want to be aware of smoking points when we’re cooking with something like olive oil. So can

Dr. Weitz: you explain the difference between smoke point [00:50:00] and is it burning and heat stability? Okay.

Dr. Ballantyne: Yeah. So I’m going to try.  This, this is, I’m going to try. There, we’re getting into some really interesting physics phenomenon here. So, what is making a high quality olive oil have a lower smoke point, which is the temperature at which it will start to smoke is 

Dr. Weitz: And people automatically assume that means that the oil’s getting damaged.

Dr. Ballantyne: Yes, it kind of, so it is sort of. So it doesn’t necessarily mean oxidation of fat, so there’s other things in the olive oil that are starting to burn. So it is some, but it is other compounds, and these are compounds that are taken out in the refinement process in a regular olive oil. That’s why a refined olive oil has a longer shelf life and has a higher smoke point.  So it’s more like these other compounds are there that they can start to burn at a lower temperature and then that can trigger a bit of a downstream [00:51:00] chemical reaction for making some of the fats oxidize. So if you heat an oil to smoke, point. If it’s really smoking, like if I’m in my kitchen, if I overheated the pan, I didn’t realize it, if I’m putting the smoke, if I put the oil in and it smokes a little bit, I’m going to take the pan off the heat, I’m going to throw something in it, food, not water, don’t, don’t, not water, food in it to cool it down real fast, I’m not going to worry about it.  If I throw it in and it is like, smoke detector, like I need to throw on the fan over the range because it is smoking that much, I’m gonna toss that, I’m not gonna, like that is now going to have a lot of oxidized fat in it, and it can happen quite quickly.

Dr. Weitz: Right.

Dr. Ballantyne: So, that being said, If you’re staying below smoke point, which most cooking applications will be like, like olive oil hat, depending on the quality of olive oil, it’s going to have a smoke point in the like 360 to 410 range.

Yeah.

Dr. Weitz: I’ve seen 375, 350. [00:52:00] Yeah.

Dr. Ballantyne: Most like baking is getting to like a hundred and sixty like anything in the oven, right? That your actual functional temperature is not as high Like your surface temperature on the food is not as high as the oven temperature, right? That’s because that’s that’s how cooking works. 

Dr. Weitz: Wait, wait, wait, wait.  I don’t think most people understand that So, so if you bake vegetables in the oven and you put the temperature at 375, the food’s not at 375

Dr. Ballantyne: Not yet. Yeah, it takes, so the food, so think about the heat transfer. Okay. So your food starts off, let’s say at room temperature. Okay. So it’s, it’s, it’s starting off at, I don’t know, 70 degrees.

Dr. Weitz: Right.

Dr. Ballantyne: You rub some oil on it, some, some seasoning, you put that in the oven at 375. Let’s say the smoke point of your oil is 375, right? So you’re right at that that line. You are, until you’re at a point where the food is starting to burn, you are not at a point where that oil is going to be hitting the smoke point because the food [00:53:00] has, it’s like a heat sink, right?  So it’s absorbing the heat, from the rest of the oven, but the temperature of the food, where that oil is, isn’t coming up to the temperature of the oven yet, until, right, until you’re, it’s starting to burn, but in that like, nice phase of like, I’ve got a little browning, a little roasting, it’s very, very delicious, you haven’t hit the smoke point of the oil.

Okay. If you pull the pan out. Things are starting to burn. You pull the pan out and you can see smoke coming from the pan. You overdid it. So typically for me, if I’m roasting vegetables, I actually typically do them at 375, but I’m using an olive oil that’s going to have a smoke point more in the 400 to 410 range.

So like I never, I’m not risking it, by having the oven temperature higher than the smoke point. But like this is why you can bake with olive oil, right? Like baked goods, the internal temperature typically is getting up to 160 is typically where a baked muffin or, you know, a cake or something is, is done.

So most of the time, even on your pan, [00:54:00] The temperatures that you’re cooking with in your pan are probably more likely in the 300 range than in the 400 range. Again, unless you’re overheating the pan, which can happen. So these fats are absolutely fine to cook with. It is the vitamin E and the polyphenols are helping to prevent oxidation, but also just those monounsaturated fats are more heat stable than a lot of other, a lot of other oils.  So absolutely fine to cook with. But if, if you, if you whoopsie, and we all whoopsie, it’s fine. Like that is a normal I’m cooking at home experience, and you’re getting a lot of smoke, off of that oil, I, I would recommend tossing it and starting over.

Dr. Weitz: Okay, so you can cook with olive oil, you can bake with olive oil, but just keep the temperatures down below the smoke point.  So if your olive oil has a smoke point of 400 or 375, you know, then don’t roast at 450, roast at 350 or something like that. And with the pan, if you’re making eggs or something on a pan, just don’t [00:55:00] put it up to the highest heat and just watch to make sure that the oil’s not.

Dr. Ballantyne: Most pans don’t like that either, right?  Like most Most of your pans aren’t even as like, I mostly cook on stainless steel. My stainless steel pans don’t want to be cooked, like heated up on, on maximum heat either, like they’re going to warp. So it’s, it’s good for the oil and good for your cookware.

Dr. Weitz: So does higher nutrient density of your food correlate with better health outcomes and or longevity?

Dr. Ballantyne: Yes, so, what we know is that people who get more, have a more nutritious diet, who have fewer nutrient shortfalls, who are, like, eating more of these nutrient dense foods, eating, right, eating more vegetables, eating more fruit, eating more seafood, like these foods that are very nutrient dense, they have reduced risk of heart disease, all cause mortality, cardiovascular disease, type 2 diabetes, cancer, Alzheimer’s disease, osteoporosis you know, like a list goes on and on and on. Do we have studies looking at people [00:56:00] following Nutrivor yet to be able to say that? Not yet. Not yet. But Nutrivor is very much built on the scientific consensus around the importance of nutrients and the overall eating patterns that are shown in a wealth of studies to support long term human health.

Dr. Weitz: You state in your book that being overweight is not necessarily associated with being unhealthy and that you can be overweight, or obese and still be metabolically healthy. Isn’t it the case that in the U. S. Very few people are actually metabolically healthy. In fact, one study published in 2018 found that only 12 percent of Americans were actually metabolically healthy.

Dr. Ballantyne: Uh, yes. So there’s a little bit of a difference in how, like, how metabolically healthy is defined. So the study that said that only 12 percent of people are metabolically healthy used a like more rigorous definition. There’s been other studies that, you know, basically it’s like how [00:57:00] many health markers have to be normal to be called metabolically healthy and how many are allowed to be abnormal, before we start calling you, metabolically abnormal.  Uh, so it’s like do you say zero markers, one marker, or two markers? And that’s, that’s kind of how it’s searched for hard to compared the actual stats in some of these studies because they’re using a slightly different definition. So, in one study that I quote in the book, it showed that basically about half of overweight people are metabolically healthy.

About a quarter of normal weight people are metabolically abnormal. We can’t directly compare that to the 12 percent study because they’re using a definite, a different definition. So, of like how many of these markers and which markers exactly we’re looking at. So it makes it a little bit tough, tough to, to do a direct comparison there.

I think the, rather than getting like into the weeds of the actual number because of that challenge with how it’s defined in different studies, I think the more important thing is to take that step back and say, look at this number of overweight and obese people. It’s about a third of [00:58:00] obese people, about half of overweight people who you know, have normal blood pressure, normal serum triglycerides, normal CRP, normal fasting insulin and glucose, normal A1c, like, they are the example of people who are not experiencing metabolic health detriment.

And when you, regardless of how you define, like, how rigorously you define metabolically normal versus abnormal, The, the, when you start to striate these populations based on other things other than BMI and you look at, for example, physical activity is, physical activity is the strongest indicator. So people who are physically active regardless of their weight have a vastly higher percent chance of being metabolically healthy and people who are inactive regardless of their weight have a vastly higher chance of having metabolic abnormalities.

Other factors that are influenced. are things like diet quality how much sleep we’re getting, right social determinants of, [00:59:00] of health. Uh, so that’s reflected in things like socioeconomic status and race and ethnicity. So it’s complex. And I think that because, because we have these large population studies showing, you know, 50 percent of overweight people are metabolically healthy.

Again, regardless of these differences and how different studies define it. The, I think the take home from there is these other things like physical activity, like diet quality are where the focus needs to be, right? We also see that most people regain weight when they lose it, right? That weight loss diets are not sustainable.

I’ve gone through this experience myself, having lost substantial amounts of weight three times in my life. Uh, hopefully third time’s the charm. We’ll see. It’s, it’s such a I think anybody who’s gone through it, so I can say from my own personal experience, the science backs this up, but this is my own experience.[01:00:00]

My health has not correlated very much, very well with my weight. So I have had very, very good health at moments in time where I have been heavier. And I have had very, very poor health at moments in time when I have been lighter and vice versa, right? Like, but the correlation is not really, you can’t really, you can’t really line it up.

But I can line up how my health has. related to my stress levels and I can line up how my health is related to my activity levels and my overall average diet quality. And so what I want to do with Mutivore is create that focus on the health habits that somebody who is obese, those are health habits that typically will lead to, to weight loss.

Maybe not for everyone. The great thing is it will lead to health independent of weight loss. So I’m trying to, create something that’s weight inclusive, that is certainly compatible with weight loss goals. You can definitely apply a NutriVer philosophy to [01:01:00] an energy deficit. Like that is absolutely something that you can do.

And actually I would recommend it because the less the gain, the harder it is to get all of the nutrients that we need. So the more that nutrient density focus is actually important. But I don’t want. The benefits of a healthy diet to feel unobtainable for somebody just because they haven’t had success on a weight loss plan in the past.  And by shifting that focus to the things that actually matter for long term health, independent of weight, that’s what I’m hoping to achieve is improving people’s health. And it’ll be, you know, individual whether or not that goes along with weight loss.

Dr. Weitz: Right, and you’re also trying to shift the focus away from all these restrictive diets and, you know, in the functional medicine world we constantly have discussions about, you know, which is the best diet, the vegan, the carnivore, you gotta avoid food BODMAPs, you gotta avoid lectins, Oxalates, Histamines, [01:02:00] on and on and on and people are constantly, oh I don’t know if I should eat that food because it might create oxalate and you know it it just gets kind of crazy end up with uh people on very very restrictive diets and that’s not healthy.

Dr. Ballantyne: I agree completely. And I think it’s not, I mean, there’s two challenges with restrictive diets. First is the fewer foods you eat, the harder it is to actually meet your nutritional needs from those foods. So that is kind of goes against the, the NutriVer philosophy. But the second one is we’ve got psychology research dating back to the nineties showing that restrictive diets lead to disordered eating patterns, emotional eating, weight regain cycles.

It’s, it’s when you define a diet based on the things you’re missing. and that you are depriving yourself of. It doesn’t set us up psychologically to sustain that diet. So on Nutrivore, we really talk about sustainable nutrition. So how do we increase diet quality, but without depriving us of our favorite foods?

Other than for medical reasons, that’s obviously a separate, that’s obviously a separate thing over [01:03:00] there. But how do we intentionally make room for what I call quality of life foods in order to sustain that overall higher quality diet? So that is a large part of the discussion in the first part of the book.

Dr. Weitz: Yeah, I feel like you’re in some ways carrying forward kind of the Part of the philosophy of Dr. Jeffrey Bland, who I used to, every year, go to his lecture he would give. I used to listen to his audiotapes, and when everybody was engaged in all these diet wars, and they still are, of course, he’s always talked about emphasizing the quality of the food and not just, you know, how much fat and how much carbs, and we’ve got to look at the quality, and, and that’s what this is sort of getting to.  Let me, let me ask you one more question and we’ll wrap. You mentioned 12 foundational food families in your book, which are the categories of foods with the most nutrient density. So I thought this would be a good way to kind of sum, sum up this discussion. [01:04:00]

Dr. Ballantyne: Yes, so the 12 foundational food families are all of the foods that have something unique to offer us nutritionally, that have a really like solid foundation of scientific studies showing us health benefits of the nutrients those foods contain.  It doesn’t mean we have to eat all of them. So, for example, one of them is seafood, and if you’re allergic to seafood, or you can’t access it because it’s not affordable to you, like, it’s, it is, none of those foods are a absolute 100 percent must, but they are the foods that help, expedite the goal of getting all of the nutrients our bodies need from the foods we eat, which is our bodies.  the goal of Nutrivore. So they are the foods that make achieving that the easiest. And when we prioritize, I, I lay out serving targets per day or per week, depending on what food we’re talking about of these 12 foundational food families in the book. That adds up to like a third to maybe half of our, of our food intake, depending on, on, on what you’re choosing.

It is a small portion of the overall diet, but when we do that, that gets us most of the way to [01:05:00] achieving our, our nutrition. goals, you know, our daily values of everything across the board. So they are very much about achieving that goal efficiently so that we have the most room for rounding out with whatever other foods we want.  So the 12 foundational food families are, I will just list them vegetables in general, root vegetables, leafy vegetables, cruciferous vegetables, mushrooms, alliums, that’s the onion family, fruit in general, berries and citrus fruit, seafood I already mentioned, legumes, and nuts and seeds.

Dr. Weitz: That’s great. This is just an aside.  I just recently became acquainted with one of the downsides of eating fruits, which is, for some reason, in the last couple of weeks, our house has become inundated with fruit flies.

Dr. Ballantyne: Oh, I have, I have two suggestions for you. Oh, really? Wow. Yes, let’s, great, perfect, perfect question to wrap up on. So, So I will say, you can buy these little, they’re like yellow look at like fruit fly traps or, gnat traps [01:06:00] on Amazon or wherever.  They’re these little pieces of yellow sticky, they’ve got some kind of coating on it that attracts insects. So in my house they’ll also, Find the occasional mosquito that makes its way in. I got rid of fungus gnats on one of my plants from them. And then I was like, what if I put this close to the bananas?  What will that do to the fruit flies? Oh look, it catches them. So that is the lowest, lowest effort one. But the free option is get a like old plastic, like a plastic water bottle, something like that. Stab some holes in the side so that there’s a way in, but the great thing about stabbing it, I use like a metal, like skewer for meat to stab, stab a ring of holes around the outside.

And then I stick, you can either use a string to like put a little bit of banana, it works really well. But a little bit of fruit either on a string that is like then tied with the cap. So it’s dangling down. or you can use like a bamboo skewer or something like that to put it in [01:07:00] so that you’ve got a little bit of fruit towards the top.

So the rotting fruit in there is going to be slightly higher than the holes. And then put like a half inch of water at the bottom with a drop of dish soap. So fruit flies are amazing at getting in. They’re not very good at getting out. They gorge themselves on the fruit and then they drop into the soapy water and drown.  And it is a fun project to do with kids. Definitely, highly recommend. Uh, careful with the stabbing things, because sometimes kids get a little excited by that. And it works, and it works, I definitely, it’s the, it works better than the sticky stuff. But then you do have that. And then when you’re ready, I just put, tape over the holes and throw the whole thing out.

Dr. Weitz: Oh, cool. That’s great. So tell our listeners how they can get a hold of the book and find out more about you, Ann. I’d

Dr. Ballantyne: love to. Thank you. Uh, so the book is called Nutrivore, The Radical New Science for Getting the Nutrients You Need from the Food You Eat. It’s available from just about any online bookseller and lots of local bookstores.  You can also request it at your local library if they don’t already have a copy. My website is neutrovore. com and that’s where like all of the really academic deep dive articles that are like the supporting evidence for everything in the book. Uh, that’s where all of those live and on social media, on TikTok, YouTube, Facebook, Instagram, threads, and Pinterest.  I’m at Dr. Sarah Ballantyne.

Dr. Weitz: That’s great. Thank you so much.

Dr. Ballantyne: Thank you.


Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy. Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a 5 star ratings and review.  If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. Some of the areas I specialize in include helping patients with specific health issues like gut problems. [01:09:00] neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen, and to help you promote longevity.  and take a deeper dive into some of those factors that can lead to chronic diseases along the way. Please call my Santa Monica White Sports Chiropractic and Nutrition office at 310 395 3111 and we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

Dr. Dipti Sagar discusses The Management of Constipation at the Functional Medicine Discussion Group meeting on May 23, 2024 with moderator Dr. Ben Weitz.  

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

8:20  “No organ in the body is so misunderstood, so slandered, and maltreated as the colon.”  “Besides death, constipation is the big fear in hospitals.”  The goal of the presentation is to understand the pathophysiology of constipation, including the diagnosis, the presentation and pattern recognition, management, and the association with the gut microbiome, as well as other illnesses.Constipation occurs in 10 to 20% of the population and about 700,000 individuals present in the ER for constipation every year in the United States.  And 10 billion is spent annually on laxatives.

10:42  Slow transit constipation vs obstructive defecation.  You want to ask your patients two questions related to constipation:  1. How frequently do you have a bowel movement, and 2. Do you have difficulty with evacuation?  If you only have a bowel movement every two or three days or even longer, then this indicates slow transit constipation. If you have difficulty with evacuation, then you have to start thinking about obstructive defecation, the most common form is pelvic dyssynergia. 

12:05  Secondary causes. There are a number of secondary causes of constipation, including diabetes and hypothyroidism, medications including opioids, NSAIDs, anti-cholinergics, calcium channel blockers and diuretics, and iron supplemention. Other secondary causes of constipation include neurological disorders, including Parkinson’s disease, Multiple Sclerosis, and dementia, and myopathic diseases that include scleroderma and amyloidosis, and structural disorders, including colon cancer and strictures.

 



Dr. Dipti Sagar is an Integrative Gastroenterologist and she is presently sharing an office with Dr. Sam Rahbar at LA Integrative GI and Nutrition in Los Angeles, California  (310) 289-8000.  You can find more information at the LAIntegrativeGI.com website.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com. Thanks for joining me and let’s jump into the podcast. Hello everybody I’m Dr. Ben Weitz. Thank you for joining our functional medicine discussion group meeting.  I very much apologize for no food tonight. Unfortunately, Chop’s Eatery, who we ordered the food from, decided to go out of business yesterday.  So, sometimes stuff happens. I hope you’ll consider attending some of our future meetings. Next month we have Dr. Darren Ingalls, who’s going to be speaking about Lyme disease, and that’s going to be June 27th. July 25th, Alan Barrie on Hypothalamus, Pituitary, Adrenal Access. We don’t have a speaker yet for August.  September, we have Dr. Pimentel. I encourage everyone to participate and ask questions, and if you’re not aware, we have a closed Facebook page, the Functional Medicine Discussion Group of Santa Monica, so you can join there and we can continue the discussion. I post a lot of research studies there and have discussions about functional medicine.

I’ll be recording this event, and I’ll be posting it as part of my Rational Wellness Podcast, and you can find that on Apple Podcast, Spotify, YouTube. If you listen to the Rational Wellness Podcast, please go to Apple or Spotify, give me a five star rating, set a review, and our sponsor for this evening is Integrative Therapeutics.  I’m going to ask Steve right here to comment. Tell us about a few integrated products. Thank you, Steve. 


Steve : Thank you. Hello. Thanks for coming. Glad to be here.  I, the topic is constipation, right? Yes. That’s not a huge thing for us. We had a great product called laxative formula.  Unfortunately, we discontinued it. We do have a really nice formula called Motility Activator that, works as a, almost like an adaptogen for the gut. And so whether you tend towards loose stools or constipation, it actually helps with both. It’s a high potency ginger and artichoke extracts.  It’s a great formula. We sell a lot of it. That’s it right now. So maybe Dr. Rahbar will, I’ll listen and learn something tonight. We’ll come up with something new. Also in the back we have some of the, we have a couple new ones. There’s a vitamin D with K. This new, we kind of got into this late, , which is how we kind of roll, but this is a good thing because we’ve, we waited until sort of the, the science was clear on which [00:03:00] nutrients and how much to use.  So it’s a really, really good formula. That’s, it’s a 5, 000 IUs of vitamin D, 180 micrograms of K2, and it’s about half the price of K Force. So if you use K Force, it’s the same formula at about 25 bucks. We also have a brand new Mag threonate that I don’t even have, it’s that new, it came on our website today.  That one is also gonna be similar, it’s a high potency Mag threonate with a low cost. And then we have samples of Cortisol Manager, which you guys all know about and also the new curcumin, which is called Curalieve.  So get those.

Dr. Weitz: And then of course, one of the main causes of constipation is, is Methane SIBO and you guys have the elemental diet. 

Steve : Yeah. So we talked a little bit about the elemental diet. It’s, this is not the place, there’s too much to go into with the elemental diet, but it’s the only Real one out there right now. I guess Mark Pimentel’s come out with one that’s close, [00:04:00] but it’s super high in carbs So if you’re interested somebody already did tonight talk to talk to me about the elemental diet We also have last one.  We have a product called Blue Heron And I’ll just it’s it’s a oldie but a goodie. And the reason it’s called Blue Heron is because Blue Herons poop a lot. So If you happen to want to try that one, it’s something we can talk about too So there you go. Thanks for coming.


 

Dr. Weitz: Thanks, Steve. And so our speaker for tonight is Dr. Dipti Sagar, and she’s a integrative gastroenterologist who works with Dr. Sam Rhabar. And so why don’t you go ahead and introduce yourself, Dipti, and get started. Thank you. 

Dr. Sagar: Can you guys hear me okay? Yeah. Okay, so a very good evening to everyone. This is such an honor presenting here this evening, not only because I get to meet like minded physicians like you all, but because of how profoundly this has affected my life as a physician.  I first got introduced to holistic integrative medicine, then after several years of practice as a gastroenterologist, As a medical director in a big county hospital, doing thousands of endoscopies and coloscopies, and giving PPI to my patients like candies, I realized that a lot of my patients were not getting better.  So that made me look into what we are missing in traditional medicine. So I started to dig deeper and wanted to see some non traditional ways of treating my patients. And then I had my own journey. where I started having GI issues. Yes, a gastroenterologist with heartburn. And very quickly I realized that I could not take those medications that I was prescribing to my patients.  And that really put me [00:06:00] into this path to explore non traditional ways of healing. And I started this two year fellowship with Academy of Integrative, , , , Academy of Holistic and Integrative Medicine, where I really learned a lot, but unfortunately I could not bring those concepts into my previous practice.

But that said, I do believe that when you have an intention, the universe makes it happen for you. Just like we didn’t have a laptop today, but someone just walked in with a laptop. So when you have the intention, it happens. And I guess that’s how Dr. Rebar and me found each other and we started this collaboration together to do our practices together because of similar mindset.  And I’m really so very grateful for that collaboration because it has infused love, passion and life in medicine for me. And I really call this my rebirth as a physician. And to my surprise, my patients were very accepting of this kind of a model where I’m combining traditional medicine with holistic and complementary medicine because I thought I’m going to get so much pushback from my patients.  But instead they looked at me and said, what took you so long? This is what we have been waiting for all along. So really it changed my relationship with my patients as well. So without further ado, because I know I have to condense my 15 to 20 years of experience treating constipation into just 60 minutes, and now I actually have only 55 minutes, so let’s begin.

Dr. Weitz: Well, we have till 8:00 pm.

Dr. Sagar: All right, so I’m going back. Let’s see. There we go. So my collaborators for this presentation is Dr. Rahbar and Dr. Erdman.  So, as a gastroenterologist, I can very well relate to the first statement, which is that no organ in the body is so misunderstood, so slandered, and maltreated as the colon. And as physicians and providers, some of you probably working in a hospital setting, could relate to the second statement, that besides death, constipation is the big fear in hospitals.  So what is the goal of today’s presentation? We are going to understand the pathophysiology of constipation. We are going to learn about diagnosis, management, presentation and pattern recognition, association with gut microbiome, as well as other illnesses.  And we are going to understand the principles of management.  Let’s talk a little bit about the disease burden.  So, it affects about 10-20 percent of the population, and to be honest, it’s very underdiagnosed because a lot of the patients, they don’t even come to physicians for this, and they just think that this is normal, or they just have to live with it.  So this is just reported 10-20%.  It does affect the quality of life [00:09:00] in a similar way to congestive heart failure or rheumatoid arthritis. About 700,000 individuals present in the ER for constipation every year in the United States. And can you imagine, like, 10 billion is spent annually on laxatives?

Okay. So, when a patient walks into your office, and probably your 10th or 15th or 20th patient of the day, and they say, Doc, I’m constipated. That’s when all hell loose break, loose break, right? And you’re like, I’m ready to quit medicine, right?  But to be honest, it doesn’t have to be that way. And today I’m going to equip you with tools that you can use so that you know exactly what questions to ask this patient, what tests to order, and how to manage them, so that it doesn’t have to be that difficult. So when you walk out of this room today, you’ll be more confident in taking care of these kind of patients, okay? [00:10:00] So as we discussed, consultation is common, but it is challenging, and we have to have a systemic approach in evaluating these patients, so that we can treat them effectively.  However, I wish it was this easy. It’s not. So, what are the few questions that you’re going to ask the patient?  I’m going to give you two questions, which is going to kind of open your mindset as to where, which direction you would be going. The first question is, is it infrequent passage of stool?  That means they are not moving their bowel every day, or they are taking two, three days to move their bowels.  If that’s happening, if the patient said yes, then you have to stop thinking about slow transit constipation. That means the transit of the colon is not as well. 

The second question is, do you have difficulty with evacuation? Because if this is the problem, that they are not able to evacuate, then the problem is not because of the [00:11:00] transit, but you have to start thinking about obstructive defecation.  And one of the most common ones is pelvic dyssynergia. I’m going to go into details of all of this, but this, these two questions will kind of help you understand which direction you have to go. Also remember that constipation can be a distractor. That means there could be a lot of underlying chronic systemic conditions, the presenting symptom of which is constipation.

So you have to explore that. Just don’t think it’s constipation and just laxatives. We have to do more tests. We have to dig deeper into the root cause of that constipation. So this is a simple list, but it’s not complete as you can see, there’s a variety of conditions that can cause constipation. It could be hormonal imbalance like diabetes, hypothyroidism.  It could be problems with the uterine. Honestly, this meditation list is pretty short. It’s not a complete list, but these are the [00:12:00] common medications that can give constipation. So you have to ask the patient, did you change your medication recently? Is there something new that was added? And even old medications can take like a year or so, like calcium cannel blockers do have constipation, so we have to take that history.

Neurological disorders like Parkinson’s disease, spinal cord disorder, myopathic disorders, and of course we have to think about structural disorders like colon cancer, rectocephaly, things like that.  So what’s the next question?  Is this chronic constipation?  Is it because, you know, you were admitted to the hospital, had a surgery or a c section and you got morphine, maybe that’s why you’re constipated, then that’s not chronic, right?  That’s related to the opioid execute. So how would you know if it’s a chronic constipation? Well, if the constipation is present for at least three months for a duration of six months, that’s how we define chronic. And if it’s chronic, then you have to ask this question. Is it Functional Constipation or is it IBS [00:13:00] Constipation?

I actually got this slide from Gastro of 2020 and it summarizes very nicely what’s the difference between Functional Constipation and IBS Constipation. So with Functional Constipation, about 25 percent or more of the times they will complain of straining, lumpy stool, sensation of incomplete evacuation.  Very important, use of fingers to dis-impact yourself. This is extremely important and especially, I see this a lot of time in women and I’m passionate about it because middle aged women, they will come to you saying that they have been constipated all their life. And it started at the age of 18 and they have never had a regular bowel movement.  The very next question that I always ask them, do you ever use your finger to dis-impact yourself? And if the answer is yes, you already know that you’re dealing with an obstructive defecation, most likely pelvic dyssynergia. Okay, so that’s one point. And then in those cases, you [00:14:00] will never have loose stool.  They will always complain of hard, lumpy stool. As compared to IBS constipation, where it will always be associated with some kind of abdominal pain which is relieved with defecation.  The stools would be either infrequent or inconsistent and about less than 25 percent of the time they will say that they have a loose stool.  So loose stool is present in IBS but not in the functional constipation.

So, the chronic constipation could be either normal transit, slow transit, , dyssynergic defecation, or it could be a combination of the two. It could be slow transit with dyssynergic defecation. So a little bit about the slow transit, it is also called a lazy bowel syndrome, and as we said, there is decreased motility of the colon.  The etiology is really very poorly understood, but there could be a lot of things at play, like lack of fiber, it could be autonomic neurology, the interstitial cells of Cajal are actually the colonic pacemakers, and [00:15:00] sometimes abnormalities of those can decrease the motility. And we cannot undermine the role of, neuroendocrine, systems like pancreatic polypeptides, serotonin, because those also play a role in the colon’s motility.  This is different from obstructive dedication, as I said, and with dysnergia, especially in women, there is a problem with the pelvic floor which cannot relax, or it could be a spasm of the anal sphincter. Decreased rectal sensation, where even though stool is present in the rectum, they don’t feel the urge because the sensation is less.

So that can also happen. And then weakness in the pelvic floor, if they have multiple vaginal delivery, during this difficult childhood, they could have things like rectocele, internal collapse. And when you have, these things, they can either cause a physical blockage to evacuation, or sometimes they form these pockets, and that traps the vagal contents, causing obstruction.

So, how do you [00:16:00] identify patients with primary functional chronic constipation? So again, as we said, thorough history taking, asking them everything, when it started, frequency, medication. The visceral stool chart, honestly, we should all have this in our office, a big one on the wall. If you don’t have it, please carry it in the size of a pocket.

A picture. The reason is that I feel like whether you’re having soft or hard stool is a very relative term, which is soft or, , you know, formed for one person can be like a loose stool for another. So this picture kind of generalizes it so that it’s very uniform for everyone. And if your patient says that the stool looks like type 1 or type 2, you have to start thinking about slow transit constipation because why?

It takes, that means the stool is passing through the colon. For a long time. And what is the role of colon to absorb water from the stool, right? So if it stays in the colon for a longer time, your stool is going to get harder and harder And that’s why they have type 1 and 2, [00:17:00] then you have to think about slow transit.

This, the third thing that you have to think is I cannot actually, tell you how important a pelvic floor and anorectal exam is that you need to do on all your patients with chronic constipation. And I’m going to tell you six points that you need to look when you’re doing that rectal exam that’s going to give you so much clues as to what’s happening with the patient.

And then, ultimately you have to do the anorectomy for these patients to differentiate slow transit from pelvic dyssynergia, and we’re going to talk about that as well. So digital rectal examination. So the first thing, the very first thing is inspection. So even before you put the finger into the rectum, you have to separate, the cheeks with both your hands and look around.

What are we looking at? We are looking at external hemorrhoids. Is there a bulge? We are looking for internal hemorrhoids, which are prolapsed. We are looking for any irregularities because [00:18:00] then you have to start thinking about rectocele. You have to look at the vaginal area. Is there a vaginal prolapse?

You have to look at? If there is a scar, are we dealing with the anal fissure? Are the holes around? Are we looking at fistula? Right? So inspection is very important. We look at those things. The second thing is sensation. So we are going to do the endocritoneus reflex. So usually I use a Q tip. So one end has a cotton and the other end is like wooden and we are going to check that sensation in all the four quadrants at 9 o’clock, 12 o’clock, 3 o’clock, and 6 o’clock positions.

And if there is a contraction of when you do the, the reflex there, it’s normal. However, if you don’t see any contraction of the skin, then you use the wooden side. And if you see contraction now, then it is, abnormal or impaired. And the absent is when you, even with the wooden side, you cannot see any, , contraction.

Next is palpation. So when you insert the finger, you have to see the consistency of the stool. Is it a hard stool? Is the patient [00:19:00] impacted? If yes, then yeah, you’re thinking about obstructive defecation. Is there a liquid stool? Or is it no stool? So patient is constipated, but there is no stool. So yeah, this is slow transit constipation then, because the stool hasn’t come to the rectum yet.

So that gives you some clue, and if you have done enough rectal exams, you would know what a normal resting sphincter tone is, right? So that is something that we need to feel at rest, and after that, you tell the patient to squeeze very hard for 30 seconds, because you’re checking if they have enough strength, if there is enough squeeze there.

If not, you have to start thinking about problems with the sacral nerve and, , probably get an MRI. The next, we are going to ask the patient to push down, , thinking that your, finger is actually a stool and they have to evacuate it. Before the patient starts doing that, you have to put the other hand onto the patient’s belly, okay?

And then you ask them to push down. When the patient is contracting the lower abdominal muscles, [00:20:00] the sphincter in your finger should feel relaxed, right? However, if there is opposite, that means the sphincter is tightening and the abdominal muscle is relaxing, it’s a problem. If both of them is relaxing, that’s a problem.

If both of them is contracting, that is also a problem. So if you see any of this, you already is thinking in terms of pelvic dyssynergia and the next step would be to, do an anorectomy. So when you do the push down, you have to see what’s the push and pull. You have to see if the sphincter is relaxing or not, and you also see if there is a perianal descent or not.

So balloon expulsion test is a useful test to test that. I recommend doing it in the office. We do it combined with anorectal immunometry, where you insert a balloon with a catheter and fill the balloon with 50 ml of water. The patient is supposed to, expel it within 60 seconds. If they are not able to do it or take longer, then again you have to start thinking about therapeutic disinertia.

We always combine this. with anorectal [00:21:00] myelometry in our office setting. I’m not going to talk about that because Dr. Edmund is going to go into the details of how we do that after my talk, so you’ll get some overview there. Let’s get to the cheese effect, the treatment. Alright. Okay. So if you have diagnosed a patient with pelvic dyssynergia, , we recommend doing a pelvic floor physical therapy.

There are several exercises that we can recommend to the patient to strengthen their pelvic floor. And I know I said women, but men can also have pelvic floor abnormalities and dyssynergia. So there are crucial exercises for men as well that we recommend to our patients. This was a good study, which was published in the Clinical Gastroenterology in 2023, an office based point of care test that predicts treatment outcomes with community based pelvic floor physical therapy in patients with chronic constipation.

It’s very interesting that we used this [00:22:00] special balloon, and it’s a foam based balloon. As you can see, when it’s deflated, it looks like that, and then you inflate it with water. The benefit of this is that the consistency feels like that of stew. So it doesn’t feel like water or air for the patient, so it’s more natural for them because it has a consistency of stew.

I always believe in going back to the basics before we start, you know, the big guns. So lifestyle, we always start with this, right? Are we drinking enough water? 60 to 80 ounces of water or fluid every day. Are you getting enough exercise? You know, because if you are moving, your colon is moving. Are you having enough fiber in your diet?

Start small. I start with one fruit every day. So I tell the patient maybe have one apple, plum, apricot, any fruit which is like high fiber with the skin for breakfast every day. Start there and see how you do. Because sometimes that’s enough, you know. [00:23:00] And then this is, , something which I always encourage my patient that a lifestyle change, which is free of cost.

And trust me, your patients will be, their ears will be all open. They wanna know what that is. You ask them to drink a big glass of warm water every morning, okay? So there is no, you don’t have to buy anything. It’s free of cost, but it’s so helpful for patients with constipation. What it does is, because the water is warm, it’s going to cause basal dilatation, so it’s increasing the blood circulation to your gut, right?

And secondly, because it’s warm, it’s also stimulating peristalsis. So extremely helpful if the patient is kind of dealing with a slow transit kind of situation. , fiber, I’m especially a big fan of bulk forming fiber, but remember not all fiber is the same. There could be soluble fibers and insoluble fiber.

Psyllium is my favorite. It is also a prebiotic because it’s broken down by gut microbiomes into postbiotic metabolites like starchy fatty acids, [00:24:00] which in turn is helpful for gut, brain, gut, lung, and gut liver access. So extremely helpful, the patients have to drink enough water with the fiber for them to work.

And remember that fiber can sometimes cause gas and flatulence, so not every fiber is good for everyone. So your patients have to try different ones to see which one works best for them. So outlet obstruction, again, we talked about high fiber will work for those patients as well. , because sometimes the sensation in the rectum, as I said, is decreased.

So your job is to bulk up the stool so that the rectum is stretching more than usual. So that they have the sensation that now they have to go. So that’s why even fiber works in outlet obstruction. Sometimes we do warm water rectal irrigation. Biofeedback, very helpful in patients with NSMIS and reduced rectal sensation.

This is something we offer in our office setting as well. , Botox injection into the pubertalis, psycho, psychological counseling, pelvic floor [00:25:00] rehabilitation as I said. Surgery is the last resort, but you have to remember that about 50 percent of your patients will have recurrence of symptoms in six, in four years.

And therefore, again, going back to the basics and doing the basic stuff is more important.

I usually get asked, like, when I’m going to order the MRI. Honestly, whenever you feel that there is an organic abnormality, like you’re thinking about a rectocele, or a prolapse, or intersusception, that’s when you get an MRI. A few words about the laxatives. Osmotic laxatives really works well. Magnesium is one of my favorites.

And the docoset is actually a lubricating laxative, but only use that for a short term. I do not like to put the patient’s long term on that. And laxatives like Senna and Dopset, , they can cause a lot of cramping. So I usually don’t recommend that. And you can use the rectum forms too, if that’s what is preferred.

A few words about magnesium, because I love magnesium, but you have to remember that not all [00:26:00] magnesium salts are the same. So if the patient is having a constipation problem, We prefer to give Magnesium Citrate or Oxide, but some of my patients, for example, my all time favorite is Magnesium Glycinate. And especially in middle aged women, in perimenopausal women, somebody who’s like 50 years old, having constipation, but at the same time they’re having perimenopausal symptoms like hot flushes, anxiety, not able to sleep at night, I always combine magnesium glycinate.

Because it has a very calming effect on the nerves, especially in that patient population. So if you combine Magnesium Citrate with Magnesium Glycinate, in those patient population, you will see significant improvement, not only in terms of constipation, but also relaxing the pelvic floor, because it has a calming effect, the glycinate.

So just a few words about, the medication. So we have Elitesia, Lenz’s, TruLenz, and Multigridly. , I’m just going to say that all of this [00:27:00] works by increasing the colonic transit. So honestly, if you are having a patient with slow transit constipation, you can consider them, definitely. They are peptides.

But remember, we always need to have a discussion with the patient and not everyone is ready to try medications. If by your physical examination and your test you have established that this patient has pelvic dyssynergia or obstructive defecation, you do not want to use this because there is no problem with the colonic transit in those patients, right?

So be very careful because if there is an obstruction and you use this, it can be very uncomfortable for the patients. Again we are not without side effects. Sorry the slide is not very clear, but this is the um. Published in 2007, the side effects of amethysia, like abdominal pain, cramps, diarrhea, flash lens, , lenses, and the true lens, same kind of a side effect.

This is the new kid on the block, IBS Ryla. , it is minimally absorbed, and it’s a small molecule inhibitor of sodium hydrogen [00:28:00] exchanger isoform 3. It is recently FDA approved for iiv constipation. You give 50 milligram twice a day with meals and again, it has side effects, diarrhea, ulence, and oph pharyngitis.

So this is another option that we can use. So as a holistic gastroenterologist, I always try to think out of the box what is it else that I can give offered to my patient because not medication has less side effects and more effective. I’m going to share some of my tools with you. And this is one of my favorites, it’s Triphala.  If any one of you are familiar with Ayurvedic medicine, you would know that this is a very potent herb, which is used in Ayurvedic medicine. It’s a combination of three herbs, Hari Taki, Devi Taki, and Amla. And it’s used in Ayurvedic traditional, medicine for years for treating constipation and inflammation.  I’m very fascinated with Ayurvedic medicine, so if you know about [00:29:00] it, in Ayurvedic medicine, you classify individuals based on their doshas. And the doshas is kind of their personality or how the body works, and there are three types of doshas.

As you can see, Triphala kind of works in all the three doshas. In fact, in India, Triphala is not only used for constipation, it’s also used for weight management. So people use Triphala to lose weight, effectively without any side effects. So I offer this to my patients, usually it’s taken half to one teaspoon, you have to drink it with warm water.

Especially if you are treating constipation at night time, it’s great. , it also comes in pill form. I do like powder form. But if you’re doing the pill, it’s like 750 mg or something like that. But it has no side effects. Very potent. The other one is, use of MCT oil. So, MCT oil [00:30:00] is the same as coconut oil, but it has the medium gene fatty acids, which is more potent because it has 90 plus, as compared to coconut oil.

And how it works, it works by loosening the stool and lubricating the lining of the colon so that it’s easier for them to pass the stool. Vibrating Capsule, this is another service that we offer in our office as well. This was a study that was published by Rao 2023, and it showed that Vibrating Capsule was superior to Placebo Capsule.  It improved constipation symptoms and quality of life, and it was very safe and well tolerated. The patients inject one capsule, for five days in a week. And this study was for eight weeks, and it showed that they, improved bowel movements to one to two bowel movements every week. So the most common side effect of the vibrating capsule was the sensation of [00:31:00] vibration, which 11 percent of the patients felt, but none of them quit the study because of that sensation, so it wasn’t that bad.  So, However, you have to keep in mind that there are some contraindications. For example, you cannot give this, give this in pregnant patients, if the patient is needing a lot of MRI studies, what we recommend is that patients should be able to evacuate all the capsules before they go for the MRI.

And for the same reason, because of obstruction or a diverticulum, you don’t want the capsule to get stuck. So they, you have to rule that out before you give it to the patient. And, , remember that the capsule has to reach the colon. to start vibrating for it to be effective. So if your patient has gastroparesis, that will not be a great candidate because it will not be like, the capsule might start vibrating even before they go to the colon.

So you don’t want to, you want to exclude those patients. And then those are nerve stimulators, pacemaker, and defibrillators. We don’t want to give them those. So the, this is a study showing the benefit [00:32:00] of Nalgimidine, which is a re opioid antagonist in patients with cancer, so more like more opioid or morphine induced constipation have shown benefit with that one.

I’m a strong believer of the brain gut connection, the vagus nerve. So it starts origins, it has an origin in the brain and it goes all the way into your colon. The rectum, however, is innervated by the sacral plexus. However, I do believe that there could be sometimes a miscommunication between the vagus they are not communicating very well, and that can cause constipation.

And as you can see, the vagus nerve can aid in digestion, it can increase gastric juice, it can promote gut motility. So yes, if you stimulate the vagus nerve, your patients with autonomic neuropathy or decreased parasympathetic tone could actually have improvement in constipation. So, this is a stimulator that we also offer in our office, very easy to use, there are several locations.

There is another study which is showing the benefit of [00:33:00] transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation in patients with IBS constipation. So, you can use the vagus nerve stimulation either in the neck or, the yellow circle around the, , in the ear, you can use there to stimulate the vagus nerve.

But do you really need a device to stimulate the vagus nerve? Not really. You can tell your patients to do these things that will stimulate vagus nerve activation like meditation, exercise, singing, massage, cold plunges in Lake Tahoe, splashes of cold water, breath work, yoga, intermittent fasting, and just hugging each other more often is going to stimulate your vagus nerve.

So we have been proving the wrong way in America all along, right? So, the right way to poop is by squatting, because when you’re sitting, the puborectalis muscle has an acute angle, as you can see here. So it’s really difficult for the [00:34:00] stool to go all the way when you have that acute angle. And that angle really becomes straight when you’re squatting.

So I really, for all my patients with constipation, I tell them that they should be squatting, because squatting is the only natural edification process. And we should really be doing this. Sometimes there is a deficiency of bile in your gut and that can cause constipation. And there comes the role of a bile acid transporter inhibitor when I feel like this is the cause because this medication can decrease bile acid absorption and increase the colonic bile acid.

And that in turn is going to accelerate the colonic transit. So this was a study that was published in Practical Gastroenterology by Virginia Schur, , about almost a decade back. And she talked about the Bell’s palsy of the gut. So when you have Lyme disease, you [00:35:00] have Bell’s palsy, which is the paralysis of the seventh cranial nerve, and you have this drooping of the face.

And the similar kind of presentation can happen in the gut, where the nerve endings get paralyzed, and doesn’t move as well. So, in all clinicians with constipation, please ask them about, you know, the history of Lyme disease, like, did they have a history of tick bite, did they go hiking, camping, and had any target lesions?  Because, yeah, the constipation, in Lyme disease is a real deal. There are other studies here which are showing kind of a similar presentation of Lyme disease as constipation.

Dr. Weitz: Could I ask a quick question? Yeah. With respect to bile.

Dr. Sagar: Yeah.

Dr. Weitz: What about the use of herbal bitters to stimulate bile production or using ox bile as a supplement?

Dr. Sagar: Absolutely. Yes, you can definitely use bitters and we use that in our clinic setting too. You can use that to stimulate the production of bile. Absolutely. So use that. But that’s another option that I showed you. [00:36:00] Does that answer your question?

Dr. Weitz: Yes.

Dr. Sagar: Very good. So, not only constipation, but as you can see, Lyme disease can affect other, can cause other GI symptoms like bloating, abdominal pain, irritable bowel movements.  So obviously, keep that in mind, you know, just like whenever a patient with multiple GI issues comes to your clinic, start thinking about Lyme disease as well. Leg poisoning is another one, , it can cause constipation, so any patient with constipation I always check their venous leg levels, to see if, leg toxicity is the cause.  Autonomic neuropathy, again can cause constipation, and the treatment is really sacral neuromodulation, so in patients with Parkinson’s disease and Alzheimer’s disease we have to think of that. And then the gut microbiome. This is really important because they are the keystone species in the ecosystem.  And, these are the organisms that really help define an entire [00:37:00] ecosystem. And not only the gut, but several organs in your body have microbiomes. including your hair, nostrils, skin, vagina, oral cavity, esophagus, the composition of the bacteria is very different. For example, in your skin there is more actinobacter as compared to your colon which has more bacteroids and fumigators.

So it’s very different. It’s like really a whole ecosystem there. However, the gut microbiome is affected by a variety of things. It can be affected with your diet. We recommend a high fiber fermented diet if you want to improve your gut microbiome. It’s also related to physical activity. Use of antibiotics is going to affect it.

Hormones, for example, if a woman is on oral contraceptive pills, it’s going to affect their gut microbiome and cause constipation. Stress, because when you’re stressed out, the gut releases CRF. which increases the cortisol level and down regulates your immunity, and thus making you more prone to, stent infections.

Early [00:38:00] life trauma, if you have pets, the use of prebiotics, heavy metals, and, , you know, the pesticides, like glyphosate, all of this can affect your gut microbiome. This is a very small list of what a disruption of gut microbiome can do to you. I don’t have, this is beyond the scope to kind of list everything, but this is just a small list.

And really, when you have a disrupted gut microbiome, which is producing a lot of methane, there is an immune dysregulation that happens and immune suppression associated with vector like Borrelia, Balesia, and Boltonia can happen. For example, if you have, a methane producing bacteria, retinobradylbacter smelii, that is really linked to constipation, and that methanogen can also be seen in colon cancer, in colonic polyposis, in ulcerative colitis, and in diverticulitis.

Dr. Weitz: Can I, can I ask another question? Yeah. Methanobrevibacter Smithii, so [00:39:00] that shows up on a stool. We, we do a lot of GI map stool tests.

Dr. Sagar: Mm

Dr. Weitz: hmm. And methanobremy factor shows up.

Dr. Sagar: Yeah.

Dr. Weitz: Ideally, it should be below detectable levels, but very frequently, it’ll be above that. It may not necessarily be in the red.  Is that something that we should be concerned about?

Dr. Sagar: Very good question. So we never look at one thing only, right? Of course. So it’s always a whole clinical picture. Whenever we have a patient like that, you have to see what are the symptoms. Are they constipated? Are they bloated? Do they have a rash? Do they have food allergy? I would probably do a SIBO test.  I’ll probably look at the gut microbiome. I’ll look if they have leaky gut syndrome. So a combination of all of that. And based on what you found, we are going to treat that. We never usually give antibiotics targeted to just that bacterial, but yeah, if you have a clinical picture of SIBO or SIFO or leaky gut, then we do address that.

Dr. Weitz: Right, because there’s a bit of a [00:40:00] controversy now about methane SIBO or EMO because now it’s recognized that it can exist not just in the small intestine, but in the colon as well.

Dr. Sagar: Yeah, it can. 

Dr. Weitz: And the question is, you know, is seeing methanobrevibacter smithii on a stool test, can that be used to diagnose methane SIBO?

Dr. Sagar: I would say it would support the diagnosis, but you have to obviously combine that with the breath test and the clinical picture. But for example, , a load of, like when I’m talking about bloating and constipation, so everything is assigned and then you have to combine those, , the points that you’ve collected to make your clinical judgment.

Speaker 8: Right.

Dr. Sagar: So if you see something like that, definitely that’s going to alert your mind to see if this is like, aha, Methane, SIBO, and you’re probably going, it’s going to prompt you to do further testing, like a breath test, for sure.

Dr. Weitz: Okay. When you do the breath test. Do you recommend three hours or two [00:41:00] hours?  We do it for three hours. For three hours, okay. It’s alright, it’s two hours. Two hours. Two hours. Yeah. Because there’s this whole issue, how do you diagnose, , methanoprebi bacter overgrowth, EMO, in the colon? So we would either need a stool test or we would need a three hour breath test.

Dr. Rhabar: I don’t have a microphone, but I speak loudly.  I mean, as you put everything together, it has never been a necessity to check the colon. I mean, I’ve talked to other GI doctors. I don’t find it very helpful to go to three hours just to look for excess methane. There would be some other indicators that methane could be a problem. The other thing I think it is probably going to touch base, is that methane will be back to its beauty age.  Methane will be a killer. You know, microbe. Okay. And, , you have to remove the oxygen from the gut environment. And generally when you see this all way, look for a fungal marker. You’re going need to sit on organic acid. You’re [00:42:00] gonna see it on the same GI map you’re gonna see on stool culture. You’re gonna see fungal antibodies, is all the clinical picture basically speaks of that scenario.  And just as another commented, I practically would never treat a SIBO with methane directly. Targeted towards the SIBO, we generally target the fungi first before you attack the methane, okay. Because the potential for giving antibiotics and switching the microbiome to a more fungal predominant is very high.  And if physicians follow the patient, they’re going to see that the effect of the benefit from the SIBO treatment is generally temporary. It’s going to come up with some other recurrence if the fungus is not addressed.

Dr. Weitz: , Sunomidressum can currently address the fungus first with something like Nystatin or

Speaker 11: would

Dr. Weitz: it?

Dr. Rhabar: Well, I mean, there are many ways to address that and it probably is another hour or two to have a discussion. Yeah. , but the short [00:43:00] version is that we treat the fungi first with Diatin, the antifungals that would be appropriate for that patient. Biofree musters. And then if we plan to treat the SIBO, then I usually keep the patient on an antifungal concurrently.  Otherwise, in my experience, you’re going to get a microbiome switch. You’re going to you’re going to have fungi have more accuracy because of their behavior. And you know, even though some of this is not completely U. S. literature, but there’s information out there from the Europeans that we have

Dr. Weitz: to

Speaker 11: get through.

Dr. Weitz: What’s your favorite biofilm busting strategy?

Speaker 11: How about we let you finish up the presentation? 

Dr. Sagar: I have a tweet for you at the end.

Speaker 11: Okay.

Dr. Sagar: Because you asked me that question.

Speaker 11: Thank you.

Dr. Sagar: Alright, so let’s get back here. So we have, we always have those patients who are constipated and they’re also bloated, right?  So that’s like a perfect combination. [00:44:00] But remember that not all bloaters are the same. And how do we differentiate that? So you could have some patient who would have constipation and bloating, but they will also see that I always have rumbling, like my stomach makes so much of noises that my partner who is sitting across the table can hear that, right?  And then when you put the stethoscope into the belly of that patient, you’re going to hear a lot of noises. As compared to silent bloaters, where they would see that they are pretty big, like bloated, But they don’t hear anything, like there is no rumbling, and when you put your stethoscope into the belly of those patients, it’s pretty silent.

So that tells you that probably the colon is not moving as well as it should. So it is probably a slow transit. Again, there could be an upstream problem, because the classic definition of SIBO is abdominal pain, bloating, constipation, and diarrhea. So, [00:45:00] if you have a patient who is constipated and bloating, I do recommend doing the SIBO testing.  And, again, a huge list of things that, , would indicate a SIBO breast test, including constipation. And I wanted to bring your attention to this, the yeast, , function, because when you have a fungal overgrowth of the yeast, um and Overgrowth, that can drive a Th17 response, which can sometimes protect from pathogens, but when you have a disregulated Th17 response, it can cause inflammation, it can cause leaky gut, it can upregulate the immune system, and cause autoimmune conditions and, , constipation as well.

So, we are going to have, a case presentation, just to kind of keep up our interest. So I have a very lovely 40 year old female who presented with multiple GI symptoms. She had indigestion, constipation, dyspepsia, flashlights, malaise, fatigue, [00:46:00] distention, so she was bloated, she had nausea. When we did the breast test, she had a methane sequoia test, which was abnormal, and then when we did the food allergy testing, she was allergic, she was allergic to multiple food items.

We did the Heidenberg gastric pH testing which showed some bile reflux and pyrolytic insubstituency. This stool test showed some Klebsiella, so she has a dysploric, , gut microbiome, and there was some candida in the stool as well. We did the urine mycotoxin screen and she was, , highly abnormal. The gluotoxin levels were 18 times that of the normal.

The live screen was positive as well. This is her endoscopy picture and this is the stomach. Usually, the stomach should not have this yellow stuff. So this is bile. When you see that, it means that there is a bile reflux and bile really has no business in the stomach. It is supposed to be going into the small [00:47:00] bowel and downstream from there.

So this patient, just to make you understand, the bile is produced over here. So, for the bile to go back into the stomach, it has to pass the pylorus, and usually that’s not the normal route. The bile should be produced and go down over here. So whenever you have a case like this, where a patient has bile reflux and constipation, the upper GI and the lower GI, you really have to target the middle man here, which is the small bowel.

So, this patient was treated for SIBO, for fungal overgrowth, and she was also treated for SIBO. With that treatment, her constipation significantly improved. And there was a special thing that we used on her, which did not only address the C4, the bacterial fungal overgrowth, but also the constipation. So to answer your question, we used Diamethaceous Earth in her case.

So Diamethaceous Earth, not only helps with the C4 treatment [00:48:00] because it’s a biofilm buster, but also with constipation. So what is Diamethaceous Earth? Well, we all love the ocean in Southern California, right? So when you go to the ocean and you look at the bottom of the ocean, there are these dye atoms and there are these crustacean organisms which were made into food grade and used as a biofilm.

So it kind of detoxifies the colon and cleanses it. So, the biofilm is disrupted and also it helps patients with constipation. So this really helped our patient therapy. So take home message is always do a thorough rectal exam in all your patients with chronic constipation. We have to stop thinking about pelvic dyssynergia because it is very common and underdiagnosed.

We have to consider balloon expulsion test with anorectal manometry in all our patients. It’s going to help you differentiate slow transit from obstructive defecation. Constipation is a very common problem and sometimes you, it’s a distractor, that [00:49:00] means there is something else going on with the patient and they present as constipation.

So we have to wear our detective hats and get to the root cause of what’s causing the constipation. And SIBO whenever you have a patient with abdominal pain, bloating, constipation, diarrhea, food allergies. Methane SIBO is associated with agonist constipation. And if you have a negative febrile test in patient with bloating, bile reflux, and IBS constipation, it may indicate the presence of a fungal overgrowth and febrile.  Thank you so much for your attention. And with that I’ll come to the end of my presentation. I’ll be happy to take any questions, but I know that Michael has prepared some slides for anorectal manometry too. So in the interest of time, I’ll have him come over and do his presentation.

Michael: Thank you for being patient.  And I’m Michael [00:50:00] Erdman. I work with Dr. Sagar and Dr. Rahbar and I’m going to give a very brief talk on anal rectal manometry because that’s what I do in the office. And it’s very interesting when you have certain cases of chronic constipation, it’s a very useful tool. So the purpose of my little brief talk is to, make you very aware of why you should refer some of your patients for this test.  that’s the button there. So brief objectives, basically just to, you know, get that message across the importance of ARN. And pretty much what Dr. Sehgal was saying, you know, one in three patients with the first line treatments for chronic constipation failed treatment. They’re the ones that you start thinking about, you know, The indication of, you know, wanting to assess their pelvic floor and to get them a anal retinometry so that you can see if they have a functional defecatory issue.

And why? And it’s basically because laxatives and fiber [00:51:00] therapies are not as effective as biofeedback and pelvic floor physical therapy. John’s already gone over this, so I’ll skip past it. and also the buzzwords in a clinic, the digital facilitation of defecation. These things you always think, anal rectal manometry, pelvic floor, physical therapy, and biofeedback.

The detailed rectal examination can actually pick up about 70 percent of cases of dyssynergia. And that’s what an ARM machine looks like. And these are the types of tests that you, , the ways that you can analyze a patient’s, , issues. So the first thing you look at with ARM is the anal sphincter pressure.

And then after that, their ability to squeeze and how effective the sphincter is at doing that. , the next thing would be looking at the myenteric plexus, and the recto anal inhibitory [00:52:00] reflex, which is abnormal in patients with Hirschsprangs, for example. The sensory motor response with hyposensitive patients that have a distended rectum.

Rectal compliance, which is, , something that you see, , that’s all about the pliability of the rectum, and whether, , , for example, elderly patients have a stiffer colon, and, , patients with Hirschsprung’s, for example, would have a more distended rectum. And then there’s the defecation tests, which is all about disinertion defecation, which is the really interesting bit.

So this is pretty much what you’re dealing with with ARN. You’re looking at a lot of, a lot of graphs. And there are four balloons attached to this catheter and they’re positioned posterior, anterior, left and right of the internal anal sphincter. And they’re color coded and then the colored heads come up on a graph.

So. When you ask a patient to squeeze, you’ll see the activity of [00:53:00] that and you’ll see the anal sphincter response. So a squeeze initially is a biphasic wave pattern. There’s initially a big spike, and then there should be this prolonged duration when you ask someone to try and squeeze for 20 seconds. If they have problems with incontinence, they’re not able to do that.

This is actually a reasonable squeeze pressure. It’s not too bad. This is a much better squeeze pressure. It’s not entirely symmetrical, but they can sustain it for 20 seconds, so that’s totally normal. So these are the kind of things I want you to see with what the, what the testing is for your patients.

Someone who has a low squeeze, , that’s a very poor effort of a squeeze, can be poor compliance. Then you start thinking neurological problems, damage to the sphincters. If it is poor compliance, they do well with biofeedback, which is something that we offer in the office. Whenever you look at someone’s ability to squeeze, you look at the cough reflex as well because [00:54:00] you see them together.

So a cough reflex, when someone, when you ask someone to cough, the abdominal pressure rises and then the anal sphincter muscle contracts. So it’s intact, with patients that have upper motor neuron lesions, and then it’s not if it’s a chordaequine lesion. So when you look at someone who has a poor squeeze and a normal cough reflex.

you think it could be poor compliance, or it could be a central motor pathway issue. And then the other way around, it would be, if it’s a poor squeeze and there’s no cough reflex, then you think an issue, for example, with the sacral reflex. This is a very high squeeze. Now, you see this in male patients that have chronic pelvic pain.

When they have a high squeeze, they usually have a very tight anus. I said that on camera. And, , you see that and typically they also have type 1 dyssynergic defecation, which is something that I’ll [00:55:00] show you. Rectal sensation is another part of the test. This is your ability to see how your patient has, what they can feel, as you inflate this balloon inside them and the balloon gets bigger and bigger.

And you say, let me know when you first feel it. Let me know when it gives you a desire to have a bowel movement. Let me know when you can’t take it anymore and you need to run to the bathroom and let me know if you have any pain. If they have pain, you stop. This is an example of someone who’s actually hypersensitive because they had a desire to go, and then with a very similar pressure, they had urgency.

You use this test to look for hyposensitivity and hypersensitivity. Hyposensitivity, they would not be able to recognize two of these sensory tests. For example, if they can’t feel anything in the beginning, you see that with diabetes. If they don’t feel a desire for, or urgency, for example, that’s with [00:56:00] constipation.

So I’ll skip this bit. , the sensory motor response. That’s when you inflate the balloon. Someone should have a urgent desire to go to the bathroom. If they don’t, that’s a sign of hyposensitivity. And then the myenteric plexus, which is that the neurons and ganglia in between the longitudinal muscles and the circular smooth muscles that work with peristalsis.

There’s a lovely test with the A RM, which is the recal anal inhibitory reflex. When you inflate the balloon, what you should see is a relaxation of the internal aim sphincter, and this is how it looks. So you have a nice increase in the rectal balloon. You know, it’s been pumped up here. and then you see a decrease of all the anal sphincter muscles.

This is a very good example of an intact rectal anal inhibitory reflux. And that’s how it also shows itself with ARN. It’s the same way. You can see all the internal anal sphincter muscles [00:57:00] relaxing at that point there. Compliance. This is all about, like I was saying, the kind of ability for the, , , rectal space to.

accommodates the increase of the stool in that zone and it changes as we get older and also with scarring to the rectum and it’s, , there’s actually a higher compliance with megarectum and faecal impaction. And then this is what dyssynergia looks like, which is really what our talk is all about, in regards to ARN, so What should normally happen is you ask someone to push when they try and poop, they push, and then the anal sphincter muscles relax.

So this would be a normal looking defecation on ARN, and this is how it would look on, on the report. Dyssynergic defecation, there’s four types. The [00:58:00] first, this is type one. It’s where you ask a patient to push and they can push really well. that the anal sphincter tightens up, right? So the pressure rises instead of falls and that’s, that’s very abnormal.

Type 2 at the top would be they don’t have a very good push and the anal sphincter muscle tightens up inappropriately. Type 3, They have a very good push and the sphincter doesn’t really tighten up. It doesn’t really do anything at all. And then type four, nothing’s working. You know, they can’t push and they can’t relax the anal sphincter.

So this is a case that I had where a patient came in with a hugely abnormal squeeze pressure reaching, you know, 300, , points on the squeeze, which is super high, like really damage your finger on a retinal [00:59:00] examination. And he was very proud of that. And then, , you know, when you, when, when he did his dis inertia defecation test and I asked him to try and replicate having the bowel movement, the balloon inflates.

And as it, as he’s pushing, you see the anal sphincter muscles are rising as well. So this is type one. Dyssynergic defecation. So if I go back to where we were, that’s what we’re looking at here, right? So you had a type 1 dyssynergic defecation with the balloon inflated and not inflated. So he was, he came back and had biofeedback with us.

Biofeedback is very similar to ARN. They look, they can look on a screen so they can see they’ve got a catheter in the bottom and they can push and when they push they can see the rectal pressure rise. and they can also play around with their pelvic floor and try and work out how to make the anal sphincter relax.

The first time he [01:00:00] came in was on the left, and you can see this was after multiple rounds, he couldn’t quite get it. On the third session, he came in with a higher anal sphincter pressure than he did on the first, the first attendance, but he had a perfect correction of his dyssynergia. Which is amazing, you know, and these, these are patients who have huge problems pooping for a very long time, right?

So, moments like this are great, and that’s the benefit of anal retinometry, that’s the benefit of biofeedback. Typically, they do much better when they have pelvic floor physical therapy at the same time. And so, then the balloon expulsion test we’ve already gone over, and I’ve already mentioned this, And Dr.

Sehgal already mentioned this article, but what was interesting, in addition to what’s already been said, is it also mentions the importance of paying attention to squeeze pressure, squeeze duration, [01:01:00] especially with an abnormal balloon expulsion test. It indicates a very good response to pelvic floor physical therapy and biofeedback.

The problem with the reports is it’s very, it can give you a mental block trying to figure out what’s going on. So Dr. Rabar and I, a couple of years ago, had had enough, and we came up with our own version, which, so now whenever people come to see us for ARN, we send them home with a lovely report. It goes to the practitioner.

Any questions you can get in touch with us. And it’s very informative so much so that the company, , Purchase the report from us as well. So now everyone has access to it, but it’s another way, a very informative way of understanding the outcome of your patients that you refer. So just to clarify once more, chronic constipation cases that fail that trial, [01:02:00] you think ARM, balloon expulsion testing, because it’s thought that there’s 50 percent of these cases out there that are actually functional, , dyssynergic problems, and only 2 percent are tested with anal retinometry.  The most important thing is getting these patients the treatment that they actually need. Biofeedback, pelvic floor physical therapy, that’s what it’s all about. As rapidly as possible. And treatment, you can actually help dyssynergia cases up to 90 percent of the time. So, it’s very valuable. And that’s actually the end of my talk on Anal Rectal Manometry, and I just came up with that.

 


 

Dr. Weitz: Thanks for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy, Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues, like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310 395 3111 and we’ll set you up for a new consultation for functional medicine and I look forward to speaking to everybody next week.

Julie Stevens discusses A Holistic Cancer Strategy with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

1:29  Cancer diagnosis.  Julie Stevens talks about being diagnosed two years ago with stage 4, aggressive and inoperable chemo resistant colon cancer.  She had no signs or symptoms but she had low iron on labs and her primary care physician recommended an upper and lower endoscopy.  Her gastroenterologist told her that she did not need a colonoscopy since she was under age 45 and had no family history, but she insisted to do the test and the gastro woke her up and told her that she had a tumor so large that she could not get the camera through.

3:19  Insistence of data.  Julie’s colon closed and she had to get surgery to remove 12 inches of her colon and 61 lymph nodes.  She met with her first oncologist who told her they would do 6 months of chemo and then do a PET scan.  But Julie wanted to test the treatment for efficacy as they went, so she refused to work with that oncologist.  She set out to build a team around her that would help her to track if the treatment was the right treatment for her as they went along. She hired an herbalist, who told her that she needed to stop eating sugar and that she could test her tumor DNA to find out if the treatment would work. She did this test and found out that her tumor would not likely respond to traditional chemo, which she told her oncologist. But she went through two chemo sessions and she tracked her response by looking at a lab test that indicated that it was not helping her, so she refused further chemo.  Then she went through immunotherapy. 

7:54  Immune System Balance.  Julie also worked on building up and balancing her immune system, so that her cancer treatments could be more effective.  She focused on her diet, getting plenty of sleep, and exercise. She also was suffering with GERD and idopathic urticaria, for which she was taking biologocial shots every two weeks and eight Zyrtec a day and 3 different pharmaceuticals.  She got off her acid blocking medications and she did food sensitivity testing from Dr. Russell Jaffe and discovered that the green grapes that she was eating every morning were giving her hives.  Not only did changing her diet and lifestyle help her control her uticaria, which allowed her immune system to focus on the cancer and allowed the immunotherapy to work better, but she also lost 140 lbs and had a complete body transformation. 

13:14  Diet.  Julie started to eat organic and initially was eating grass fed beef and eggs.  She still eats eggs nearly every day and some seafood and some poultry, but she now does not eat as much meat. She focuses on getting five colors of vegetables a day. And she eats zero sugar. 

 



Julie Stevens had a successful challenge with colon cancer and now she is helping others have a successful journey through her MOJO Health website.  Julie published a book about her cancer healing journey, Mojo Healing.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz: Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, drweitz. com. Thanks for joining me, and let’s jump into the podcast. Hello, Rational Wellness Podcasters.

Our topic for today is building a holistic healing strategy and maximizing joy on a cancer journey. We’ve had a number of discussions on the podcast. on an integrative or functional medicine approach to helping to manage cancer patients, including Dr. Nalini Chilko, Holly Lucille, Naysha Winters, Thomas Seyfried, Paul Anderson, Elise Altshuler, Gio Espinoza, and others, [00:01:00] but only a few with someone with personal experience with cancer. which is what our discussion today with Julie Stevens is about. And Julie will share her experience of how she developed a strategy and worked her way through a successful cancer journey.  Julie, thank you so much for joining us today. And perhaps you can start by telling us a little bit about your journey.

Julie Stevens: Yeah, happy to. So hi everyone, my name is Julie Stevens and today is probably my 45th birthday, so I just want to remind everyone who’s listening to be a DataG and go get your data.  That could be colonoscopies, mammograms, or annual physicals, but get your data because that’s really the story of what’s unlocked in the cancer journey.  So, it was just shy of two years ago I was diagnosed, so it was June 14th of 2022, I was diagnosed with what ended up being stage 4 aggressive and inoperable chemo resistant colon cancer.

Dr. Weitz: A heck of a diagnosis. That’s a hell of a diagnosis for anybody to deal with, especially somebody who’s new to, really, the healthcare world.

Julie Stevens: With no symptoms, no signs, no family history, under the age of screening, which was 45, so it really was.

Dr. Weitz: Which is interesting how you say you had no signs, no symptoms, and it just is something that we all need to keep in mind.  I hear so many people say I’ll let my body tell me what’s going on, and unfortunately, sometimes that’s not the case.

Julie Stevens: For me, it was just, I had lower iron than I’ve ever had before. And luckily my primary care physician took that really seriously. And I was just in the middle of a major work transition.  I was leading a piece of an acquisition we were, we had just purchased. And so my life was wildly stressful and I thought I had an ulcer. And she said, let’s go ahead and get an upper and lower endoscopy. And so I called my gastro three times. They told me, you don’t need a colonoscopy. You’re under 45. You have no family history.  And my response was like, I’m a data gal. Let’s just go ahead and get it. I’m willing to do the prep. So let’s get the data. And thank God I did because my gastro woke me up and said the tumor was so large. They couldn’t get the infant size camera to the other side.

Dr. Weitz: Wow.

Julie Stevens: That was the beginning of my journey in June of 2022, and in July of 2022, unfortunately, my colon actually closed.  So I had to go get a right hemicolectomy and have about 12 inches of my colon removed and 61 lymph nodes. Those came back, and of course, the cancer had spread. And so they had suggested six months of chemotherapy. And while I don’t know really anything about science, I’d had the luxury during the rollout of Obamacare of working with the American Hospital Association in the world of industrial psychology to define different jobs, so I understood the job and the industry of healthcare very well.  I just didn’t know science. But also taking into account my history working in the field of industrial organizational psychology, I understand how to use data to predict outcomes. That’s what I do every day. And so when the oncologist said, we’ll do six months of chemo and then we’ll do a PET scan, I said, oh no, that’s not my story.  We’re actually going to do six months, like right after the first chemo, I’d like to test for efficacy. And she rolled her eyes and said, oh honey, that’s not how we do it. So in this condescending voice, and I was like, then I’m not going to do chemotherapy. And that was the moment I went rogue because I don’t know science, but I knew data.

And if they weren’t willing to let me track the data my way, I didn’t trust that doctor. So I had to start from scratch and really build a team around doctors that would really suit what I was looking for. And I even built, again, as I’m using my industrial psychology hat. a criteria for what I’m looking for in a doctor, and actually built a selection system to find the doctors that would really play my way.  And my way was using the most current data, willing to think outside of the box, willing to challenge the standard of care. I understand why the standard of care was created, and that was to create operational efficiency. I helped organizations understand how to do that. So, I don’t look up for Operational efficiency. That’s exactly right, and that’s [00:05:00] not what I’m looking for when your life is on the line. I’d have 14 percent chance of survival.

Dr. Weitz: Interesting. And we see that all the time, unfortunately, in conventional medical care.

Julie Stevens: That’s exactly right. So luckily my first, the first hire on my team I would say was an herbalist and I walked into his office thinking he was going to tell me to align my chakras and stop eating sugar, which he did.  But in addition to that, I said, he’s like, why are you here? And I said I want to understand the data I can measure, I can use to measure treatment efficacy. And he’s oh yeah. And he pulled up a website from cancer. gov and it had,  And then he goes, but wait, I can top this. Do you want to understand the data you can use to predict if the treatment will work before you ever start? And I was like, yeah, I didn’t know that was possible. And then the third thing he told me was, listen, we can not only do that, we can build your body up so you won’t feel the side effects.  That had my attention. So hence, right away, he was hired onto the team. And in fact, he did all three of those things. So I knew I was chemo resistant before I started. My oncologist did not trust me and told me, trust me, I know what I’m doing. I’m the expert. And so I went through two chemotherapy sessions where I tracked my data outside of what they were doing.  So I was able to identify I was chemo resistant, inform my oncologist about this, do the required testing, and then pivot to what actually worked.

Dr. Weitz: Wow.

Julie Stevens: But it wasn’t just the herbalist. I also had hired, I should say, an acupuncturist, a reflexologist, a chiropractor. So I had all sorts of traditional healers all designed to really heal different parts of my body as my oncologist was working on treating cancer cells.  So I really felt like it’s up to me knowing 92 percent of cancer is built because of what we eat, drink, think, and do, or epigenetics. So it was up to me to figure out why the root causes of cancer were expressed, because it wasn’t genetic in my case, and to also use the best of any science that was available.  And for me, the science that worked was science that was released in 2020, 2022, 2023. So it was very real, like it was happening real time as I was going through my treatment. And that was not the way my, my oncologist was working. And he was the chief of staff at a major academic health center in Atlanta.  So this wasn’t a slouch or a small person I was working with,

Dr. Weitz: My podcast is devoted to Functional Medicine and you just beautifully explained what the Functional Medicine concept of how we treat patients is by looking for the root causes, getting your body as healthy as possible to be able to handle whatever care we’re going to have etc. So that was a great statement of the functional medicine mission statement without even really having any experience in functional medicine.

Julie Stevens: That’s, that’s the part of this that’s been the most shocking to me, is that I truly did not understand how much power we had when we build up our immune systems, and how critical it was, and how hard it is in today’s world.  I’ve had to change just about everything about how I live, from the food I eat, to the activities I do, to the stress I keep, and the sleep I make sure I get, and the rest. And it’s really difficult to do that, and it really takes a lot of effort when you think about how we actually live in today’s standard American lifestyle.

Dr. Weitz: What you just said about the immune system is really significant. I don’t think most patients, even cancer patients, understand that without your immune system playing a very vigorous, active role in helping to kill cancer cells no matter what other form of treatment you get, whether it’s the strongest chemo in the world, whether it’s the strongest radiation.  You’re only going to kill a certain number of those cancer cells, and there’s always going to be a certain amount of cancer cells that are not directly killed by that.  And that’s your immune system needs to be stepping in and playing an active role. And then whenever you stop your treatment, the immune system needs to be continually working on eliminating cancer cells and controlling their growth, etc. Or your care won’t be effective. And of course, you utilized immunotherapy, which is an example of some of the newer forms of cancer therapy that involve getting your immune system to play an even more active part in eliminating cancer.

Julie Stevens: I think it’s important to note though, while immunotherapy was a huge part of my strategy, I had done all sorts of work to my body so that the immunotherapy would work. So I’d gotten off of the medicine for my GERD. I also had looked at every single reason for inflammation. I think this is a really important part of my story of before cancer, I was diagnosed with cancer.  I’d had a disorder called chronic idiopathic urticaria. That means for every day for 13 years, I had hives. Sometimes from head to foot, I was miserable. Sometimes I couldn’t even brush my hair or hold a pen or walk because of these hives. And I had gone from doctor to doctor to doctor to figure out what was driving these hives.  And everyone just put me on more pharmaceuticals. So before I was diagnosed, I was taking biologic shots every two weeks, up to eight Zyrtec a day and three different pharmaceuticals to mask the hives. And it didn’t mask the hives. So flash forward to, listen, my very first meeting with Oscar, my herbalist, he said, we’ve got to worry about your inflammation because cancer feeds on sugar, inflammation, and copper.  So let’s go ahead and figure this out. And he did this test that was by Dr. Russell Jaffe. I’m not sure if you’re familiar with him. It’s an ELISA.

Dr. Weitz: Oh yeah, He’s been on the podcast.

Julie Stevens: Sure, it was the ELISA LRA test.

Dr. Weitz: And it’s like a food sensitivity test.

Julie Stevens: Exactly. And it unlocked every single reason why I had hives. So for 13 years, I’ve been miserable with this diagnosis. So not only did I heal the cancer, I healed the root causes of why I had so much inflammation. And I had to do all that preparation work for the immunotherapy to work so flawlessly. And it’s important to say, not only from immunotherapy, but also chemotherapy, I didn’t have side effects.  I was going to music festivals in Mexico during treatment, and that doesn’t happen to the average person. But because I’d done such a beautiful job of having enough magnesium and vitamin D and vitamin K, my body rode through the waves without any problem.

Dr. Weitz: That’s great. So explain how preparing your, explain how getting off your Omeprazole and doing some of the other things you did to heal your body, how did that play a role in helping your body fight cancer?

Julie Stevens: I think the important part is you want your body, and the way that this was described to me by my healers was, listen, you have an army of ten, and when you deploy your army so that they’re worried about this inflammation, and this, you have this glig plug in that creates this, and you have this toxicity, and this chemical that you’re having a reaction to, and you’re using this makeup, your body’s fighting all these wars, there’s no troops to fight cancer left. And we want all of the troops fighting cancer. So the job is to create homeostasis in every way you can so that your troops are focused on what’s important. That’s cancer cells, not on helping to moderate the impact. Because for me, it was green grapes. I was poisoning myself every morning by eating green grapes because that was my favorite food.  And come to find out that was giving me hives every single day. So, by helping my body avoid fighting the trauma of green grapes and focus on cancer, I was able to heal that. But, I think it’s important to notice, besides the, the urticaria, besides the cancer, I’ve also had a complete body transformation.  So, I’ve lost 140 pounds, every single part of my body, if you were to look at my blood markers, I look like a totally different human being. But, it’s because I was able to refocus on grounding myself every day, getting enough sleep, really healing my body the way it needed to be healed and giving it that homeostasis so it could work in its most functional, optimal option way.

Dr. Weitz: What sort of nutritional approach have you been using in your Cancering journey?

Julie Stevens: The first thing I [00:13:00] did was kind of anything that was non-organic left. So I really started to use grass fed beef and eggs and all the things. But then I started to so first thing was just as clean and as pure as I could without any chemicals.  But then I started to really get choosy about the types of food I eat. So the majority of my diet is plant based as much as I can. I do eat some seafood, I eat eggs every day, and I have some poultry but not a huge, not a ton. So I’ve really been able to shift that to be almost all plant based. I make sure I focus on getting five colors of vegetables a day.  That was my challenge for this year. Once I understood the different nutritional value of having green versus red versus purple vegetables. I understood that you can’t just eat a bunch of broccoli and think you’re going to have enough. It really is the diversification that allows your gut microbiome to really thrive.

Dr. Weitz: So you reduced your consumption of animal protein?

Julie Stevens: I did. And for me, as I mentioned, I did the ELISA LRA test and it [00:14:00] showed gluten, soy, sugar, green grapes, tuna, and scallops. So I have completely eliminated those things from my diet. Sugar was probably the hardest. And that still is the hardest because when you travel or eat out, you never know if sugar’s in the sauce or the, the salad dressing or things like that.  So it is challenging to really make sure you have a zero diet, a zero sugar diet. But as much as I can, I’ve gotten, gone to zero sugar. And then of course gluten was the thing that was, is, was a challenge to begin with. But really the reality is there’s so many beautiful gluten free products now, I don’t even miss it.

Dr. Weitz: Did you change your diet around the times that you got your treatment?

Julie Stevens: Oh, yeah, I so I should say my treatments don’t look like the average person’s treatment. So I think that’s okay. So when I did chemo, yes, I fasted. So I didn’t, I didn’t, I really, So part of my my training as an industrial organizational psychologist was I broke down every single [00:15:00] side effect that could impact me during the treatment, and I built a plan to moderate it.  So that’s part of why I didn’t have side effects. So I fasted for every single infusion. I made sure I had

Dr. Weitz: Did you fast for how long?

Julie Stevens: 24 hours before for the 24 hours of the infusion and six hours later. So I really tried to do before and after. I also like iced. So cold sensitivity, I was on oxaloplatin, cold sensitivity is a reality for that one treatment.  So I put my hands and feet in ice and I ate ice chips the entire time. So I had no problems with cold sensitivity. I had to fight really hard against my healthcare system to allow me to do that. But I was able to avoid that entire side effect of any cold issues.

Dr. Weitz:  Cool. What are some of the other important lifestyle factors that you utilized?

Julie Stevens: So you mentioned one when we started and that’s, you mentioned my mantra of maximizing joy. And I think that’s a really interesting one because that is something that’s kind of uniquely me and I think in my journey. I [00:16:00] decided when I was diagnosed and because you feel overwhelmed with fear and I immediately decided I will not do this journey in fear, I will do this journey in joy.  And that takes a lot of mental practice and really work to be able to do that. So I started to feed my mind superhero movies. So instead of watching the news, I watched Iron Man to understand what I could do. So I read books, I asked my network to send me pictures of rainbows and puppies and, flowers and all of the things because I really wanted to utilize

Dr. Weitz: In other words, Marvel Comics is directly responsible for your recovery.

Julie Stevens: For me thinking I was a superhero, that’s fair. That’s fair. And I brought that in. So part of my strategy is I went to my first treatment and I hated being there. As you can imagine, it is the worst place on the planet when you look around and you think all of these people are dying around me. And that’s what I thought.  And I thought, I can’t have this energy. So the next one, I got dressed in costume. And I brought, so basically I decided to have a [00:17:00] luau. You can imagine I walked into my second, my, my first chemo, my second chemo, my first party and walked in and said, Hey, you want to get laid in chemo and had lays for everyone and glasses and gift bags and, But part of those gift bags were I had a lot of frustration.

So I hand hammered bracelets for everyone that said, ride the wave. And I gave out 60 gift bags that day. So at the end of my first meeting this woman walked up to me and said, listen, Julie, I was planning to commit suicide tonight, and I’m not going to, because I met you and I know I can ride this wave.  And I realized right then I might be the only person that’s crazy enough to get dressed in costume and give, bring gift bags to an infusion, but every single person here needs it just as I did.

Dr. Weitz: Right. Awesome. You discuss how you use genomic data to predict treatment success. Can you tell us more about that?

Julie Stevens: Yeah. So this is pretty cool. And I think for, I’m guessing most of your listeners know this, but for anyone who doesn’t, I thought colon cancer was a thing or breast cancer was [00:18:00] a thing, but come to find out, it kind of matters where it is, but really what matters is the genomic makeup of the tumor cells.  So for me, I was a GKRAS13D, was what my tumor cell was genomically named. Well, come to find out, because I was KRAS positive, my herbalist had done research in lung cancer that showed that the platinum based chemotherapy wouldn’t work with a KRAS positive tumor. So I brought this research and my genomic data the morning of my first chemo to my oncologist and I said, listen, this isn’t going to work, let’s just go ahead and pivot to immunotherapy.  But come to find out, because of the standard of care You have to fail at chemotherapy before they’ll open up immunotherapy. He didn’t know I understood why he was forcing me to do chemo, but I understood the red tape was there because of my experience working in the field of industrial psychology. So I laughed.

So I was like, all right, I’ll do this, but I don’t trust you. But it was really the understanding the genomic fingerprint, which is required to have some sample of the tumor. So it’s not possible for all cancers right away, [00:19:00] but as soon as you can get this, I would implore you to utilize this data. And let me share, I didn’t call one time to get this data, I called over 20 times to get my oncologist to pull this data.  This is not standard to pull it this way. Typically they let you do 6 months of chemo, they fail, and then they’ll do genomic testing. But once I understood that could predict treatment efficacy, I was willing to do whatever it took so I could get that data as fast as I could and have that early in my process.

Dr. Weitz: Unfortunately, the reason why you were forced to get this traditional chemo first, it has to do with the attempt by the healthcare system, by the insurance companies, to spend the least amount of money possible and, taking traditional chemo is less expensive than immunotherapy and unfortunately that’s a factor.

Julie Stevens: It sure is, but you know what else is a factor? how your doctor is compensated. And unlike almost any other drug on the planet, your [00:20:00] oncologist is compensated based on the number of chemotherapy sessions administered. So it’s important to understand this is, and if they want to do something that is not the standard of care, the amount of paperwork and challenges and meetings they have to go through to get that approved, it’s not a small task.  So you want to find an oncologist that is a maverick, that is willing to think outside of the box and challenge those assumptions? It took me an army to get this done, but it is worth your energy.

Dr. Weitz: Yes, sometimes you have to swim upstream in the healthcare system to get the care you really need.

Julie Stevens: It’s true.  And you are your best advocate. Nobody cares about you like you do. But I knew the squeaky wheel got the oil. That’s true in everything we do. But I also knew the squeaky wheel that was positive and not a pain in the butt got better oil. So again, by throwing these parties and bringing stickers to everyone and postcards and showing my appreciation for everyone there, I got what we call incremental [00:21:00] effort from every single healthcare professional, whether it was the front desk person, whether it was a nurse, whether it was my oncologist, they all spent a little extra time with me, or came by to see me, or checked in with me, or checked in with me after my session.

So by bringing the best of who I was to these sessions, I got the best of my healthcare team as well. And I would encourage anyone listening to really think about, don’t bring sticks, bring carrots, and get them to really engage in your story.

Dr. Weitz: What was the particular genetic test that you utilized?

Julie Stevens: I used the neogenomics.  So that was, sorry Secretary, that was the specific genomic test. The genetic test I used was just through my hospital system, and they did the standard, yeah. Yeah,

Dr. Weitz: I meant the genomic test, the cancer characteristics, yeah.

Julie Stevens: Perfect yeah. So I used Neogenomics and that was really important to me. I actually had two different, I was switching oncologists at the time, so I had both of them pull, so I had Keras and Neogenomics, so I was able to compare what we thought were the two very best genomic providers out there.  It was almost the same data, but Neogenomics gave you a few extra factors. [00:22:00] And one of those To go back to your earlier question about how I change my diet, this is an interesting one. So my herbalist did mention, listen, if you’re HER2 positive cancer and olives are natural indicator of, or not indicator, but natural reducer of HER2 positive cancers.

So while I hate olives, I’m willing to eat eight olives a day if that’s what I need to do to keep my body cancer free because this is a HER2 positive cancer and olives can help reduce HER2 positive cancers. So those are the sorts of things that when you understand it, you can actually feed your body the tools it needs to repair itself.  Same thing with kiwi. Kiwi actually repairs your DNA. I had no idea until I got on this journey, but so now I’m willing to eat two kiwis a day. It’s easy when you feed your body the right things.

Dr. Weitz: I don’t think most people are aware of that. There’s data to show that kiwi repairs your DNA.

Julie Stevens: That’s exactly right. I have a podcast as well, so I have an episode with a person named Peter Broadhead, who was an herbalist, he had a nutrition store, he’s had all sorts of different environments worlds. And he came on and gave us [00:23:00] some really beautiful data about the types of foods you need to eat, so things like mushrooms, kiwi, etc., that can really impact your health outcomes. Yeah,

Dr. Weitz: mushrooms we know for their immune strengthening properties, the mucopolysaccharides. Thank you. In terms of you mentioned a few things what are some of the other ways that people can decrease some of the side effects of traditional cancer care like chemo and radiation?

Julie Stevens: Well, I’m going to say this. I actually built a tool. So it’s all available on our website for free. So you can go on and put in what chemotherapy you’re taking or any side effect of any medicine and understand the supplements, the diet, the lifestyle, or the healers you could use to avoid that side effect.

And so your question might be, how did I collect this data? Again, I’m an industrial psychologist by trade. So I understood how to build the formula and the protocol for how to do this. Then I went out and worked with experts around the globe to get the feedback on what would you do if, what can a chiropractor impact from a side effect perspective?

What can an acupuncturist impact? So I went out to each of these specialties [00:24:00] to understand what the opportunity was and did surveys to experts in those areas. So I got their feedback and then I used a number of different practitioners to help me build the list of what these supplements could be to avoid these side effects.

Come to find out, and this is one of the things that my team taught me. is if you start chemotherapy and your body’s idling at an 8, you’re going to drop to a 6 and you’re never really going to feel it. But if you start chemotherapy and you’re at a 5, and you drop to a 2, you’re on death’s doorstep.

So make sure you start these treatments as strong as you physically can be, so that when you take the hit, it’s no big deal. And so that’s part of it is, beyond everything, make sure your overall health is as strong as possible. That means staying Sleep and meditation and giving your body a rest before you start treatment.

I was walking. I literally have walked and exercised more than I ever have since I’ve been in treatment, knowing how important that was, not only from a health and wellness perspective, but for example, that helps express your lymph nodes. And for me, that was really important. [00:25:00]

Dr. Weitz: Yeah. Absolutely. I think a lot of times patients going through traditional cancer therapy like chemo feel like crap and don’t have a lot of energy.  So they tend to avoid exercise and conserve their energy.

Julie Stevens: And that’s the whole point. You, your body needs the right fuel to have energy. There was never a day, besides when I was in surgery, so let me say that, once I was healed from surgery, there was never a day when I was in treatment that I wasn’t strong enough to go to work, to go out for a walk, to make my own food.

I never had a day where I wasn’t well enough, but that was because I had done all the preparation work to make sure my body would sail. And so you’re either going to pay for it before or after. When you pay for it before, it’s a lot more enjoyable for the way you live your life.

Dr. Weitz: Yeah, you’re mentioning another concept, which is one of your principles that you mentioned, which is that when you have a diagnosis of cancer, all [00:26:00] the treatment is focused on trying to kill the cancer.

And yet, the health of the host is super important, as you’re mentioning, if you go in at a level 5 instead of a level 8, your ability to even handle the treatment is going to be greatly diminished there needs to be equal or, equal amount of focus on making sure you, your body, your health overall, I don’t know, is at a highest level possible, that you have good energy, that your blood flow is good, that your immune system is good, all these things that are going to play a secondary role in helping you to fight the cancer, survive, and also make sure you don’t die from something else.

Julie Stevens: That, so that was kind of the big thing that was a takeaway for me, is, your, is, and again, I’m using my industrial psychology brain, your oncologist job is to reduce cancer cells, it is not to make you live a long and happy life 15 years after treatment, [00:27:00] so they’re really focused on one, one microscope, and when you understand that microscope, you want them to do that, But you also need support so that you, that doesn’t kill you.

So things like when you think about certain types of radiation, that’s cool that you don’t have cancer anymore. You just died from radiation or you had this horrible chemo. I just talked to someone who was a a saxophonist for one of my favorite bands and he was diagnosed with the exact same genomic type of cancer.

And I talked to his wife. A couple weeks before he died, he had gone through the standard of care where it was one chemo, a more intense chemo the third hardest chemo. That chemo is what killed him. It wasn’t the cancer.

Dr. Weitz: Yeah, it’s sad. You mentioned six toolbox to build your strategy. Maybe you could summarize what are those six toolboxes that are important in your Cancering journey?

Julie Stevens: Yes, can I give a, I’ll give a really fast history lesson too.

Dr. Weitz: Sure.

Julie Stevens: One, you think your doctor is trained on all these things. So again, using [00:28:00] my history, I went back and studied medical school curriculum because I believe we can only hold our doctors accountable for what they know and the data they have access to.

So when I’m back, but went back and studied medical school curriculum, I understood the little that they knew about six toolboxes. So I consider the six toolboxes Pharmaceuticals, Botanicals, Nutraceuticals, Diet and Lifestyle, Environment, and Facilitated Healers. In their curriculum, is pharmaceuticals. And when I went back to understand why, it was because of something in the 1909 that was published called the Flexner Report.

So many of you might be familiar with the Flexner Report, but that’s basically where they went out to have some continuity of medical school curriculum. And in that, if you taught acupuncture, or herbalism, or chiropractic as part of your medical school curriculum, You lost funding. So in 1910, our doctors went from being jacks of all trade to masters of pharmacology.

So it’s really important to understand it’s a really valuable toolbox, but it is one toolbox and it’s up to [00:29:00] you to get your botanicals, nutraceuticals, diet and lifestyle environment and healers in line to heal everything else.

Dr. Weitz: Yeah, it’s absolutely the case that traditional medical doctors know little or nothing about nutrition, herbs, alternative care.  They’re basically taught that those things are not super important. Yeah, nutrition matters somewhat. So, don’t eat a couple of foods and that’s about it.

Julie Stevens: Don’t eat lunch meat, don’t eat sausage, don’t eat bacon, and don’t eat meat, or what they told me, but the reality is that’s so far away from the reality of how I can make my body thrive.  And when I understood that, I was like, cool, this is your box, but it was important to note, It’s not that they didn’t tell me not to take the herbs. It’s not that they didn’t tell me to do the, to eat the food. They told me, hey no, you shouldn’t do this.

Dr. Weitz: Oh, a hundred percent. In fact, those herbs are unproven.  They contain [00:30:00] antioxidants that can counter your treatment.

Julie Stevens: So I was strong enough to push back and say, if you can show me one research article that this is true versus your fear of how it’ll impact, I will stop right away. And they couldn’t come up with one research article. So I was like, cool, this is my body, what I do outside of your office, you’re responsible for cancer cells, I’m responsible for my body, you keep working on my cancer cells, I’ll keep working on my body.

But I don’t think most people are that bold.

Dr. Weitz: Right, yeah, this has been a discussion that comes up over and over again, every time we have a discussion about cancer is it’s known that traditional chemo and radiation, that One of the things that happens in the way that they kill cancer cells is by creating free radicals in the body.  So therefore, anything that contains antioxidants like vitamin C or vitamin E or any of these other antioxidants are therefore going to uncouple the chemotherapy. And yet, [00:31:00] many studies show that the more vegetables and fruits. that you eat, the more likely you are to beat the cancer, the less likely you are to get cancer.  And those are containing huge amounts of antioxidants. So it’s never really made sense.

Julie Stevens: Also, again, I’m a data girl. So let’s just say that when you look at this, your doctors, the data set they have to make decisions is disgusting. So I’ll give you a perfect example. There is one study of people who have been successful.  Like I have been. on, on, on immunotherapy with colon cancer. There’s one study. There’s not a study if they, if, what if you stop at 18 months? That data doesn’t exist. What if you do this drug for four years? It doesn’t exist. There’s one study that if you do it for two years, here’s the outcomes you can expect to achieve.

So when you’re listening to your doctor, actually look at the research they’re referencing. Understand this, the limited scope of the data they have to predict outcomes. Efficacy. It is not what you think, where they would understand, listen, if I stop at 18 months, here’s the reality of [00:32:00] your outcomes. No, they’re using the best guess based on the limited data they have, which is all we can hold them accountable for.

But the data is lacking because most companies only need data to get FDA approval, not to actually prove how to optimize the drugs so you live your best life. And that’s a different approach.

Dr. Weitz: There’s a lot of issues around data. We could talk for hours about it, but one thing to keep in mind is to conduct a randomized double blind placebo controlled trial on anything other than a drug, of course is very difficult. So, to try to run a study like that on a food, when nobody’s gonna benefit from potentially making billions of dollars from eating pomegranates or broccoli or whatever it is nobody’s gonna want to fund that study. So, those studies are not done, and we have limited data from these food frequency questionnaires, which are [00:33:00] completely inaccurate, and so we just don’t have comparable studies on Common Herbs Fruits and Vegetables many of the lifestyle factors because there’s no funding mechanism for that other than the NIH which is basically doing some of the basic research to help the pharmaceutical companies develop their drugs and

Julie Stevens: I would say yet.  I agree with you, but the answer I would say is yet. And that is why I started this non profit, Mojo Health Exist, to build the data set. Because I know my doctors have continuously said, we’ve got your data, and I’m like, you have a core of the data of what I actually did to heal this. So I know the reality is of what you did, you’re just giving credit to the pharmaceutical.

But much more went into my story than just that one drug. And so Mojo Health Exist, because I believe you’re absolutely correct. No one company is going to pay to understand the interplay of how all these things impact health outcomes. So this needs to be based on a [00:34:00] patient led revolution, and that is what I’m leading.

I want to invite patients to join together with me, so we build the data set on what we are doing, so this might not be a double blind placebo, but I can give you a correlation study to understand, listen, people who have your genomic type of cancer in Chile do this, and in Turkey they do this, and in Japan they do this, and the U.

  1. they do this, and here’s the difference in outcomes. And when we can drive people to understand how the globe heals differently, and what options can give them the optimal outcomes, and what interplay of options really helps that’s how we can change cancer. We take this out of the corporation’s hands, and we put it in the patient’s power.

Dr. Weitz: That’s great. You’ve mentioned already about using cancer biomarkers, blood biomarkers to track what’s happening with cancer. Maybe as opposed to when your oncologist told you that you would do six months of chemo and then get a PET scan to see what happened. And [00:35:00] you distinguish between the fact that the PET scan is a lagging indicator versus some of these biomarkers that can help you identify what’s going on right now. Which are you progressing? Are you regressing? Is can you talk more about some of those most important biomarkers?

Julie Stevens: Yeah, so, there’s a couple different types of biomarkers you can look at in your blood. And I think the, this is like measuring how many invitations were sent to the party.  So you understand how big is this party? What’s happening with my cancer? So when I understood the proteins that were being developed as a result of the cancer, and if those proteins are going up, You have more cancer activity. And if they’re going down, you have less cancer activity. So the first thing I looked at was something called CA 19-9.  That’s a blood marker that’s traditionally used for pancreatic cancer, but it can also be a good indicator for colon cancer as well. This is not something that’s used around the globe. It’s only used in a few countries. So it’s one of those things that my doctor said, Hey, I don’t follow that. I think you’re fine.  You’re not chemo resistant. [00:36:00] When I came back and said, Hey, I’m chemo resistant. Cause let’s be real. That was a 30 blood test that I was doing outside of my doctor. I did that on my own. I tracked and it was going up after my second chemo administration. So I texted my doctor and said, Hey, listen, I’m chemo resistant.

I’m not coming back for chemo three. And he’s like, Julie, I’m the expert. Trust me. That’s not a data point we follow. And I was like, these six industrialized countries follow this. So this is what I follow. So you need to pull data to disprove my theory in order for me to come back. Again, I don’t think most patients are quite that bold, but he, so he did two tests.  One is a PET scan and the other was CT DNA. which most of your listeners might know, but for those that don’t know, that’s looking for tiny broken particles of cancer. You’re circulating tumor DNA. And so the reality is we don’t want to use one of these tests to make a huge treatment decisions. We want to use a lot of different data points, looking at different aspects of the cancer to drive our treatment strategy.

So would I have made this decision on CA 19-9 alone? No. Was it a great indicator that we needed to collect more data? Yes. And [00:37:00] the idea here is we want to collect as much data as you can. before you start treatment. And I think that’s a really important thing. Doctors don’t tell you, hey, this tumor is not urgent.

They don’t tell you that. And as soon as you’re told you have cancer, you think, I want this out of my body as fast as we can. But the reality is my cancer was growing for over 10 years. I had a month to stop, collect my data, get all my baseline information, build my team, build my body, take the time to do that, because then the way you ride is much smoother versus jumping into treatment, and you’re like, and then you’re already knocked down a few pegs.  So I just wanted to mention that urgency thing is really important and to get all that baseline data so you can measure the score of the cancer early on and know when you need to fail and pivot.

Dr. Weitz: Right. I was reading that Your herbalist acupuncturist was also looking at things like zinc and copper and CRP and inflammation levels and things like that.  And some of these markers indicate what’s [00:38:00] happening in the body that is gonna change the terrain that the cancer is growing in.

Julie Stevens: That’s exactly right. His biggest focus was, are you going to have a blood clot? Because you’re going to die way faster than the blood clot than the cancer. So let’s make sure your blood’s in great order.  Your neutrophil and lymphocytes are in line. Like, let’s look below that first level to understand really what the score is of the health of your body and the health of your terrain. So it’s not just one, it’s really all of it.

Dr. Weitz: Right. And most cancer patients are going to die from heart disease despite the cancer.  So you don’t want to beat the cancer and die of heart disease.

Julie Stevens: Which that’s, when I understood, I was a little angry when I learned this fact, that most cancers are a metabolic disease. And in fact, if you keep your body in line, you will not only not have any heart tumor cancer, you won’t have heart disease.  So why don’t, why didn’t I know that until I dug into this world? That to me is such an important fact for everyone to understand. You can avoid heart [00:39:00] attacks.

Dr. Weitz: Yep. And that’s called the Metabolic Theory of Cancer.

Julie Stevens: Yeah.

Dr. Weitz: And that’s something a lot of people in this space have been talking a lot about, including Thomas Seyfried and Nisha Winters.

Julie Stevens: Nasha Winters was the book where, I mean, my herbalist said this, and he is a friend of Nisha’s, so he talked about her, and I was like, I don’t believe you. And so I had to go do my own research, and after talking to so many doctors and going to conferences and reading these books, I was like, I believe you and not only do I believe you, I want to shout it from the rooftops because I know we can create a body that’s inhospitable to cancer.  And if given the opportunity, we need to prove exactly what we need to do to do that because everyone who’s had cancer will do that to not have a recurrence.

Dr. Weitz: Yeah, Nasha had a diagnosis similar to yours. She had a stage 4 ovarian cancer and basically was left to die and probably the fact that she felt so horrible and couldn’t eat and end up fasting for close to a month is probably what [00:40:00] helped her body fight the cancer.

Julie Stevens: For sure.

Dr. Weitz: So let’s bring this to a close. Let’s finish on the topic of trying to find joy in your healing process. And then tell us about your contacts.

Julie Stevens: Yeah, so, I think, one of the most things, the best things you can do for your body is to not live in fear, as I mentioned, and so I worked really hard to use joy.  So as I mentioned, I dress up in costume, I bring gift bags, but it’s more than that. It’s I look at every single day and realize what I’m grateful for. I start every morning by focusing there, not on the fact that I had to fight cancer. I never once looked at that as a cross to bear. That’s an invitation to change.

Right. And you reframe your thinking as, okay, the world’s got to change. Like my world is not the same as it was yesterday. Things are different. I’m willing to accept this change. I’m willing to take on the change and do what I need to do. It wasn’t a hardship. My life is better and I’m happier [00:41:00] post cancer diagnosis.

Dr. Weitz: Nasha Winters often talks about instead of fighting cancer, cancering, and how you’re basically going through this journey.

Julie Stevens: It is not a death sentence. It is a life sentence though.

Dr. Weitz: That’s great. So how can listeners find out more about your program? You have a podcast, you have this website with helping cancer patients figure out how to work their way through this process.

Julie Stevens: Yeah, so I basically, as soon as I was declared no evidence of disease, I made a list of all of the reasons why cancer sucks. And I have one by one tried to systemically answer those reasons. So it started with I wrote a book so that you would understand how to build your team. And then it started with, wait, we can do better than this.

Actually, I’m going to write a job description so that you understand what your role as a patient is. Okay wait. Now I’m going to write tools so that you understand how to select a doctor and how to build this team. Now we went forward to, as I was working with my herbalist in this team, I was like, Guys, we [00:42:00] can build this so that anyone can go and figure out how to avoid side effects online.

So, that is all available for free on MojoHealth. org. Mojo Health, which stands for More Joy. Because that’s why every joy comes back to everything. So mojohealth. org is the place where you can go and we have built all sorts of resources. I just launched a what now guide for newly diagnosed so it’ll walk you through the very first questions you should be asking, the types of data you can really start to gather to change your strategy, how you can build your team so it walks you through step by step.

But we’re also just about to launch a what now guide for caregivers because we want to help people understand how they can gift better. And so this is one of the things I would mention is just this week one of the challenges I’ve faced and let’s be real, very little of what I did to save my life was covered by insurance.

I’m facing financial devastation as a result of saving my life and no one should have to face thousands and thousands of dollars in debt despite the fact that I have a wonderful job and a healthy savings account. All of that is gone because [00:43:00] this is, these are the reasons why you have a healthy savings account.

So one of the tools we’re building is a registry so you can go on there and build your strategy and share that with your network and someone else can buy you a bottle of magnesium or vitamin D instead of a coloring book or a Or dropping off lasagna or flowers that dies. So let’s actually teach people how to help you with what you need.

So I am just taking this off one list at one, one challenge at a time. And you’ll see that in my podcast. We’ve done podcasts, everything from how to have financial wellness after diagnosis to how to prepare. So you don’t lose your hair with capping. to most recently we just did one on how to prepare your body for radiation.

So we are talking with experts around the field, just all about cancer, the stuff that isn’t what your doctor teaches you, but really can change your game. So we’re going to not stop until I’m in the grave, because I know from what I know that we can have, we can make cancer suck less, only if we work together and share the best practices and tips that each one of us share and that one on one level to a [00:44:00] much broader audience.

Dr. Weitz: We can make cancer suck less only if we work together.

Julie Stevens: That’s exactly right. Hence the name of my podcast is Mojo Rising, How to Make Cancer Suck Less,

Dr. Weitz: thank you so much, Julie.

Julie Stevens: So grateful to be part of this and thank you so much for helping me spread Mojo with the world.

 


 

Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast.  For those of you who enjoy Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues, like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive [00:45:00] health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition Office at 310-395-3111. And we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

 

Dr. Trent Orfanos discusses Integrative Cardiology with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

1:33  Functional Medicine.  Dr. Orfanos was a conventional, interventional cardiologist. He has a daughter with cerebral palsy and he and his wife took a Functional Medicine approach to her health, using nutrition, supplements, exercises, and patterning. She went from unable to crawl to walking on her own. But he continued to practice conventional cardiology until 2010 when he was looking for a wellness program for hid cardiology practice and he went to a meeting on supplements and it was a real epiphany for him and he started applying it and his patients got better and healthier.  He was convinced.

3:06  The Mediterranean Diet.  Dr. Orfanos believes in the Mediterranean diet, which is one of the most well-studied diet and it includes fruits and vegetables, nuts and seeds, fish, and some meat. It also includes plenty of olive oil and legumes. He is also comfortable using olive oil to cook with and he points out that he is Greek and the Greeks have been using olive oil to cook and fry with for millennia.

 



Dr. Trent Orfanos is the Director of Integrative and Functional Cardiology at Case Integrative Health in Chicago, Illinois. Dr. Orfanos practices invasive interventional cardiology from 1982 to 2019 but he embraced preventative cardiology from the functional Medicine perspective starting in 2010 and exclusively from 2019.  Dr. Orfanos has board certifications in Internal Medicine, Cardiology, Integrative Medicine, Functional Medicine, and Anti-aging Medicine.  He is also an associate clinical professor of medicine at the Indiana University School of Medicine. His website is caseintegrativehealth.com/cardio.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

 

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, drweitz. com. Thanks for joining me and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Today, we’ll be having a discussion on integrative cardiology with integrative cardiologist, Dr. Trent Orfanos. Dr. Trent Orfanos is a director of integrative and functional cardiology at Case Integrative Health in Chicago, Illinois.  He practiced invasive interventional cardiology from 1982 to 2019, but he embraced preventative cardiology with a functional medicine perspective starting in 2010 and exclusively from 2019. Dr. Orfanos has board certifications in internal medicine, cardiology, Integrative medicine, functional medicine, and anti aging medicine.  He’s also an Associate Clinical Professor of Medicine at the Indiana School of Medicine. Thank you, Dr. Orfanos for joining us today.

Dr. Orfanos: Well, thank you for having me on. It’s great to be here.

Dr. Weitz: So maybe we can start with the transformation in your career. How did you decide to move from the dark side into the light?

Dr. Orfanos: Well, you know, the once you see the light, it’s hard to go back.  And so I can say that my story, excuse me, my story goes back. I have a daughter that’s I have four daughters, so I’m blessed. And the first one was born with cerebral palsy, which is a brain injury. She couldn’t walk or crawl even up until the time she was three. And we adopted what turned out to be a functional medicine approach to her health, not knowing what it was called. And it’s a lot of patterning, exercises, nutrition, supplements. She went from unable to crawl to like walking on her own, which astounded her doctors who didn’t expect it.  So that was a first aha moment. And

Dr. Weitz: That’s great to hear stories like that.

Dr. Orfanos: Wonderful. And so that was, she was, she’s now 43. And and then 2010, I. I was looking for a wellness program for my cardiology practice and I went to a meeting on supplements because I thought that I wanted to know more about them.  And it was just a real epiphany for me and it all came together.  It took a while but and I started applying it.  Patients just got better and healthier and they weren’t getting healthier before and now they are.  So I was convinced.

Dr. Weitz: That’s great. So maybe we should start with diet.  So what are your thoughts on a heart healthy diet? 

Dr. Orfanos: Sure my my background’s Greek; all my grandparents were from the old country.  And so the Mediterranean diet is probably one of the most well studied diets in the world. And it basically that’s, so that’s one of my favorite ways to recommend eating.  It’s not low fat. There’s plenty of olive oil and some animal fats in there too. Fruits and vegetables, nuts and seeds, fish. It’s and that encompasses so many healthy phytonutrients that are in there. It’s and it translates into less fat. Heart disease, less dementia, less diabetes longer life expectancy.  It just pays off all the way around.

Dr. Weitz: I liked the Mediterranean diet, but I will say that when you look at the studies, there’s a little squishiness around the edges, like one study will say it includes legumes. Another one will say it includes cheese or eggs. Another one will say it includes bread.  And there’s a little vagueness there.

Dr. Orfanos: Yeah. Yeah. And that just to me, that just [00:04:00] goes to show you that, you gotta be flexible, in your diet that growing up with this being just inherently part of my life, I never experienced like some people didn’t need legumes and some did, they all did.  They were all, we had, bean soup on Sundays.  But it was like a routine thing. I’d say it includes all of those things. I know carbs and bread and gluten are sometimes get a bad rap, in, in the, when you wrap it around that whole high olive oil, polyphenol diet, those things seem to be like be okay.

Dr. Weitz: Right. What about saturated fat? It’s been popular for the last number of years in the functional medicine world. There have been some prominent books that have come out saying that saturated fat, butter, egg, cheese, etc. don’t really contribute to heart disease, that it’s not really saturated fat, the real problem is sugar.  What do you think about that?

Dr. Orfanos: I think probably back in the, what, in the sixties, I think the speaking of that kind of thing, the seven, yeah,

Dr. Weitz: Those big studies and those studies have been criticized and

Dr. Orfanos: I’m more on the side of, saturated fat in and of itself is not bad. You’re eating in the context of.  Of these healthy animals were raised healthy. You’re eating it with olive oil and and, boiled greens sprinkled with olive oil and lemon juice. And

Dr. Weitz: And this kind of, in other words, eating some grass fed meat or some organic chicken that has saturated fat is not really a problem because it’s in the context of a healthy diet with olive oil and these other healthy fats.

Dr. Orfanos: That’s the way I see it. It’s a holistic approach. It’s everything that you’re doing that’s going to make you better. It’s hard to isolate. I’m just going to have some saturated fat today by itself.

Dr. Weitz: But people do have questions like, What should I be using to cook my eggs in? Should I use butter? Should I use coconut [00:06:00] oil? Should I use, olive oil? Should I use avocado oil?

Dr. Orfanos: I can tell you that even though you get this, Oh, don’t fry things in olive oil because the olive oil gets ruined by doing that we Greeks have been frying things in olive oil for millennia.  And I just can’t, I don’t buy that, that I understand what you’re saying. It gets maybe trans fatty or whatever, but that’s just, isn’t the way people live. Okay. They use olive oil for everything. They don’t go out and buy avocado oil or coconut oil. They use olive oil for everything. And they do pretty well.  There’s blue zones in Greece,

Dr. Weitz:  What about coconut oil?  Is coconut oil a healthy oil?

Dr. Orfanos:  I think you can use coconut oil for high heat situations. It is, of course, a saturated fat, but I think it, I feel like it’s okay to use it. I wouldn’t like make that your exclusive fat, right?  I think olive oil is probably where I’d like it to go. Maybe avocado oil. If I had,

Dr. Weitz: I know myself, I switched to coconut oil for a while for high heat cooking for like when we bake vegetables. And when I started using it consistently, my small, dense LDL started to go up and my LDL particle numbers started to go up.  So I switched over to avocado oil for high heat cooking. And then I use olive oil for lower heat cooking.

Dr. Orfanos: I think that sounds really wise.  And some people that may have, you’ve probably heard of the APOE genotype. If you’ve got the E4, you probably should go low fat, low saturated fat, because those people respond like that. They, their LDLs and particles go up too high.

Dr. Weitz: Okay. When let’s go into testing. When we take more of a functional integrative approach and we’re trying to assess the cardiovascular system usually we want to do more detailed testing than a standard lipid profile.

Dr. Orfanos: Yes. I, I routinely do advanced lipid panel testing. So what is that? So beyond the usual LDL cholesterol total triglycerides and HT l we do we look at the lip, the LDL particle number. So LDL cholesterol is gets the name bad cholesterol, but depends if it. If it’s oxidized or not.  So we look at how many particles there are in there, the more particles, the more risky it is. We look at the size of those particles, so small particles are more dangerous. So big particles are like beach balls bouncing around inside your arteries. They don’t cause much damage, but small ones are, they’re like golf balls, They can hurt, when they hit the walls.  And that’s relatively what the way I like to think about it. We’re looking for beach balls instead of golf balls. And we want them, we want, we look at inflammation markers too. And we want to make sure that everything is

Dr. Weitz: What are your favorite inflammation markers?

Dr. Orfanos: High sensitivity C reactive protein is like pretty universal. It’s not specific, but, if that’s high, that goes along with all kinds of risk for bodily chronic disease you can imagine. 

Dr. Weitz: Right.

Dr. Orfanos: There’s oxidized LDL, ox LDL, that’s the hot inflamed golf ball LDLs. And there’s a Lp(a), Lp(a), the one that’s that you can check. And if that’s up, that implies inflammation actually within the vessel wall.  And then you do things that are common to lower inflammation. And a lot of it circles around the foods that we eat, like the Mediterranean diet, that’ll bring those down.

Dr. Weitz: And what other components of testing are included?  Do you, are you running like homocysteine levels?

Dr. Orfanos: Yep, I routinely run homocysteine levels.  I’ll check hemoglobin A1c, which is a marker of how high your sugars have been for three months. And fasting insulin levels. I’ll check uric acid because it’s a risk factor too.

Dr. Weitz: Yeah. We can thank Dr. Perlmutter for bringing that on the radar screen as a metabolic marker.

Dr. Orfanos: Yeah. He’s, I really appreciate that he brought that up.  I check the RBC levels of omega 3 fatty acids or fish oil. That’s, if there’s one thing you can do. If your Omega 3 Index, your RBC Omega 3 Index, that’s DHA and EPA, if that’s at the highest levels, at 8 percent or more, compared to those, most of us running around at 4 ish or so.  When you’re up here, there’s less death from any, from all causes. That’s death from heart disease and cancer.

Dr. Weitz: Yeah, I try to target above 10 if I can.

Dr. Orfanos: Oh, that’s tremendous, yeah, if you can get up that high. If you’ve got the E4 genotype, Dr. Bredesen’s Alzheimer’s guy says, It 10 percent your goal, but if you can get it a 10 fine.

Dr. Weitz: What do you think about HDL? For a while was considered super important High HDL was supposed to be protective and I would say in the last five years the importance of LDL has been somewhat called [00:11:00] into question and then we now see that high HDL above 80 is actually often considered to be non functional and actually not good.  And so we’re trying to assess more HDL functionality these days, but it’s hard to assess that.

Dr. Orfanos: Yes, you can do myeloperoxidase, which is a sort of a surrogate marker for dysfunctional HDL. So that’s something that can be done. Also it’s if you’re making a lot of HDL, I heard somebody’s HDL was like, I had this one patient of mine.  She was an elderly woman. Here, HDLs were like, 110 and she was, she had terrible vascular disease. Your body’s making more of a dysfunctional that doesn’t an HCL doesn’t work. So it just keeps pumping out more trying to make up for it. And it’s a sign of, like you say, dysfunctional HCL that don’t, that doesn’t work.

Dr. Weitz: What do you think about TMAO? 

Dr. Orfanos: Oh, that’s a, yeah that’s a tough one because TMAO goes up with eating fish, for instance. So I’m like, I’m thinking, wait a minute, if you eat fish, you’ve got less heart disease. I’m more with eat the healthy diet. It should contain fish.  And I don’t say ignore the TMAO, but to me that’s. I’m going to say, maybe it’s heresy, but I’d say that’s secondary to, to the healthy diet idea.

Dr. Weitz: When you look at the data on TMAO, a lot of it’s dependent upon the gut microbiome. And I’ve had I was running TMAO regularly for a while and a lot of patients, if they had a healthy gut, Would have a normal TMAO no matter how much fish or meat they were eating.  So I think it might be a marker for an unhealthy gut more so than really for cardiovascular disease.

Dr. Orfanos: And that sounds like the old functional medicine axiom, start with the gut.

Dr. Weitz: [00:13:00] Exactly.

Dr. Orfanos: Somebody just go for their gut and get that working good. And the other things fall in line.

Dr. Weitz: So if we discuss some of these markers that you see tell me, what are some of your favorite strategies to address?  So for example what’s the first thing you think about doing for a patient who has an elevation of LDL particle number? And if they have a lot of small dense LDL.

Dr. Orfanos: Okay. Usually it starts, it starts with food. So those people are, generally eating a high carb, high sugar, inflammatory food type diet.  And you need to start turning that around. It’s hard to change people’s food. They’re very much attached. We all are. We’re attached to what we like, so we don’t want to change. But if you can eat low carb Mediterranean you’re going to, and perhaps do some intermittent fasting, which I think is overall a good idea.

That can turn around just with that. And then things like omega 3 fish oil they’ll flip that too. [00:14:00] You’ll get your particles, number goes down, your particle size goes up, your HDL goes up, inflammation comes down. It’s just a win. Those are good. I’ll use I’ll use some I’ll sometimes use berberine as far as berberine is insulin sensitizing and lowers LDL cholesterol.  It’s It works like these shots called PCSK9 inhibitors. It’s got that kind of function.  That’s cool.

Dr. Weitz: It’s one of the few things that’s been shown to reverse plaque.

Dr. Orfanos: I didn’t, I’m not sure about that. Did you see that?

Dr. Weitz: Yeah. Yeah. There’s at least one or two studies showing that I’ll send them to you.

Dr. Orfanos: Okay, that’ll be great. I’d like to see that. There’s there’s other there’s another supplement out there that’s made that, that comes from seaweed. This is secondary but actually it’s pretty good. That can actually reduce plaque and especially the vulnerable.

Dr. Weitz: You talking about like the Arteriosil

Dr. Orfanos: yeah, Arteriosil. Yeah. I think that’s amazing. Yeah. Endothelial function. Function and glycocalyx. The linings of the artery. Yes. All that gets [00:15:00] better. We forget about, there’s strategies to try to heal all that, which is gonna help that artery work better. Of course you gotta get your lifestyle right.  You got to be eating right, you got to be exercising, you got to be sleeping correctly. You got to watch your stress. You can’t be walking around, wired and angry and all that all day long because that’s going to, that could distort everything you’re trying to do. What else can I tell you?

Dr. Weitz: Let’s see. What if you have small dense LDL? How do we make that LDL particles larger?

Dr. Orfanos: Those will change all those strategies I mentioned, they that’ll flip that the LDL particles will become bigger, fluffier and less dense.

Dr. Weitz: Okay. So you mentioned some supplements, any other supplements you use for LDL?  Do you use red yeast rice?

Dr. Orfanos: I use red yeast rice. That’s one of the more effective ones because it, as it contains a statin, basically, that’s where they found it. Those monoclones are where they purified the statin. They took it out, purified it, made a drug out of [00:16:00] it. So those, that works pretty good.  You gotta use enough, but you can get LDLs down.

Dr. Weitz: Yeah. You got to use at least 2, 400 milligrams.

Dr. Orfanos: Yeah. Yeah. You can go up to 4, 800 if you need to.

Dr. Weitz: Yeah, exactly. Citrus bergamot. Have you used that one?

Dr. Orfanos: I don’t use much of that. Doesn’t seem all that effective. I think Red Yeast Rice has got an edge, got a, it’s better.  It’s better.

Dr. Weitz: Yeah. Yeah. I definitely think on the supplement side, Red Yeast Rice is one of one of the supplements that’ll move the needle the most, or the supplement that’ll move the needle the most.

Dr. Orfanos: For LDL, sometimes you can use like Annatto E it’s gamma delta tocotrienols. Those will do it too.

Dr. Weitz: Yes. Yeah. I’m a big fan of those. Dr. Bertie Tan, we’ve had him on the podcast a couple of times.

Dr. Orfanos: He’s wonderful. He’s great.  Real kind guy too. Yeah. So that’ll work.

Dr. Weitz: And then when do you use medications?

Dr. Orfanos: If I have people that come in and they’ve got [00:17:00] established coronary disease, I had a lady come in today and she’s got, she just had a heart attack in February and she’s got a stent in the very heavily calcified coronary artery. I said, I, this is where statins, this is where pharmacology, the benefits outweigh the risks. If you’re a 40 year old guy with a cholesterol of 230 and somebody puts you on a statin and there’s nothing else going on, I don’t think that’s, the payoff is pretty small there.  But for her, the payoff I felt was good. So I put her on a low dose of the statin.

Dr. Weitz: Which, which statins do you prefer the most?

Dr. Orfanos: I like Crestor or Resuvastatin. It’s Pretty potent. It’s one of the more potent ones as far as Statins go. It it’s got a pretty long half life, so you could use it like, three times a week instead of every day, if you’re people are having trouble with it and still you get pretty good results.  And it’s water soluble, now that’s arguable, but that may, it may be less side effects with the water soluble ones than the fat soluble ones. Yeah,

Dr. Weitz: I know a number of cardiologists who feel that way.

Dr. Orfanos: It’s worth doing. And then they got these new drugs out. I mentioned the berberine like drug, the PCSK9 inhibitors, those are shots that just, all they do is there’s these receptors in the liver that suck out the LDL and when you take the shot, you get more of them they don’t break down, so they persist.  So your LDL comes out. Very few side effects, people get by pretty good with those compared to statins. There’s another one that’s Bempedoic acid, that’s a drug that just works in the liver, seems to have really low side effects and does the job.

Dr. Weitz: Yeah, some doctors I know, some cardiologists who want to use the medication and for patients who don’t tolerate a statin they’ll sometimes use Bempedoic acid and Zetia.

Dr. Orfanos: Zetia, yeah, it’s a combo, they come as a combo, which is nice. So one side. The Bempedoic acid stops the production side, which is what most people concentrate on, but the Zetia stops the absorption side. So you get it from both ends, so you can get a pretty substantial drop with that.

Dr. Weitz: [00:19:00] Right.  Have you run that cholesterol absorption versus production test?

Dr. Orfanos: I haven’t done that.

Dr. Weitz: Yeah.  Boston heart.

Dr. Orfanos: Boston heart does that. I’m not against it. I just haven’t done it. I just try stuff, yeah. I’ll try the statin or slash, or one of the others, and then I’ll add Zetia, and then sometimes you get some profound benefits.

Dr. Weitz: You usually recommend CoQ10 with statins?

Dr. Orfanos: Oh, yeah. So you get, the CoQ10 gets depleted with the statins so does vitamin K2, so does fish oil, so does vitamin D. A lot of things get

Dr. Weitz: Yeah.

Dr. Orfanos: drug nutrient interaction thing. And you want to get that CoQ10, if you can, above three. That’s the goal for a good, for best cardiovascular outcomes.  Okay. I measure those two and see where they’re at and supplement.

Dr. Weitz: So what’s your best strategy for a lipoprotein A, LP little A?

Dr. Orfanos: That’s a tough one. I’ll still use niacin in spite of this Article that kind of was condemning it. Maybe [00:20:00] that’s a strong word.

Dr. Weitz: Why don’t you, why don’t we talk about that article for a minute?  So for those who are not aware, there’s a recent paper in Nature by Dr. Stanley Hazen, and he argues that when we look at niacin consumption. There’s a couple of downstream metabolites, one in particular that he claims might be dangerous.

Dr. Orfanos: Yeah, the 4PY and 2PY, yeah, and those down there, , actually, Dr. Houston sent me an article right when the, some of this niacin stuff came out that just showed the opposite, that people that were put on niacin had better cardiovascular outcomes.

Dr. Weitz: Yes.

Dr. Orfanos: They may say this trumps it, because it’s a more recent article, but I don’t know. I, I’ve been using it for For years for a decade or more, maybe more than that since I was doing conventional cardiology and although I’m just me, I haven’t noticed any ill effects as far as cardiovascular outcomes from using [00:21:00] it.  Think it does so many good things raises a LDL particle size decreases LDL particle number increases HDL and HDL functionality lowers triglycerides. I mean that all that’s. going to pay off. I guess one of the questions is if you’re genetically predisposed to make more of these inflammatory metabolites, maybe you’re at some risk.

Dr. Weitz: But that’s one of the points I think one of the critiques I have of that article that Dr. Houston mentioned when I talked to him, which is that that paper is indicates that only certain genetic subtypes are going to produce those metabolites. And in order to see if those metabolites are really dangerous, I was just reading the article last night.

They tested to see if there was a correlation between 2p y or 4p y and heart attack or stroke or [00:22:00] Other cardiovascular disease and it was really no correlation. So all they have is this in vitro analysis that’s associated with certain inflammatory factors And so I think it’s very weak evidence and especially for a nutrient, niacin, which is commonly found in all these healthy foods.  Yes, it’s in animal products, it’s in salmon, it’s in avocado, it’s in all these healthy foods. And it’s really hard to think that this common B vitamin is potentially dangerous.

Dr. Orfanos: Yeah, I feel the same way. And it’s also difficult to apply these sort of the drug mindset.  How do I test a drug? I test, this one molecule for this one disease, and I see what happens. And then I make broad claims about the drug. Okay, but nutrients are a whole different problem. Animal, they’re, they interact with everything that you’re doing. You’re, the [00:23:00] air you’re breathing the activities you have, the other vitamins and nutrients you’re taking.

So that’s, I don’t think you can draw those kinds of strong conclusions like that. But like you say in vitro and then he brings up like he says in this study niacin didn’t help and maybe even increased risk in another study. So he’s combining them and making a claim that because that other study showed something.  That therefore this this this concept that he had must be true, yeah,

Dr. Weitz: He brings up a couple of old studies that in my mind have already been refuted like eight years ago, but he brings up the HPS thrive study and the HPS thrive study didn’t just use niacin. He used niacin combined with a drug Laparipant.  Yeah, it was a drug developed by Merc and the laparapant was designed to reduce the flushing that some people get with niacin.  Which by the flushing is not harmful. It’s just some people don’t like it and that drug had a bunch of side effects and that study The patients had the side effects that were already attributable to that drug.  And then they said that showed that niacin might have these side effects and wasn’t effective. So that wasn’t a very accurate way to assess the effectiveness of niacin. And we got a bunch of other studies that have shown lots of benefits of niacin.

Dr. Orfanos: Yeah, exactly. And I believe was it thrive or aim high?  I can’t remember what aim high. Yeah.

Dr. Weitz: Aim high. They found that there was no benefit, but if you actually go back and read the study, it significantly lowered LDL. It significantly did all these positive things that we know are associated with increased cardiovascular health.

Dr. Orfanos: And one of them was, I forgot which one, was using a drug that was, the idea was to raise HDL, I believe, if I got that I think it [00:25:00] was to raise HDL, and it turned out to be, have a worse cardiovascular outcome, and then they tied it to niacin.

Dr. Weitz: Yeah, I think that’s that lap, laparapan, yeah.

Dr. Orfanos: Yeah, that one there, so I think. So anyway it’s like guilt by association kind of a thing, niacin, niacin was even combined with what was, what did they call it? There was a drug out that combined niacin and never core.  I think one of the first stands.

Dr. Weitz: Yeah. I think both those studies, HPS thrive, in addition to that laparapan that was included in the HPS thrive, Both of those studies had patients on statins and niacin, and they were testing to see if statin plus niacin was better than statin without niacin.

Dr. Orfanos: So I’ll still use, I still use niacin for people with high LP, little now having said that, those PCSK9 shots like Repatha, they’ll lower LP little A probably by a third, by 30 percent or something like that.  Whereas statins, if anything, they might raise it a little bit, [00:26:00] 10%. They really don’t do anything. And then there’s a new, there’s these new drugs coming out, siRNA drugs that are like, they’ll knock it down 90%. They’re, if they come out, then they’ll, that’ll be the answer for people with LP little a that’s I have a patient who’s serious with sputum.  450 today.

Dr. Weitz: Even yeah it’s interesting. I sometimes talk to primary care doctors and they don’t want to run lipoprotein A. And when I tell them that we should run it, They tell me it’s a genetic factor, so why run it? But lipoprotein A, Lp(a), is typically not being run in most patients, unless they see somebody like yourself or like me, who has a functional medicine approach, because there’s no drug for it.  But once that drug is out, everybody will be running it.

Dr. Orfanos: Everybody will be checking it. Yeah. And, if you know it’s high, to me, to be forewarned is to be forearmed. So if I know you’ve got high LP little a, I’m going to be real aggressive in managing your LDLs [00:27:00] and your other risk factors, because whatever I do, I’m going to blunt the negative effect of that LP little a.

Dr. Weitz: And niacin can get you 30, 40 percent reduction. You can get a little more from from L carnitine, there’s several other agents that can help push it down a little more as well.

Dr. Orfanos: I did, I don’t get that much out of niacin. I may get 20 maybe 30, if I’m lucky.

Dr. Weitz: Okay.

Dr. Orfanos: Then I just, I haven’t checked this out yet, but one of my, I was at a functional medicine meeting and I was talking to Dr.

One of the cardiologists there that probably won’t know, and you may know her, Mimi Guarneri, she’s out on Oh yeah,

Dr. Weitz: yep, I’ve

Dr. Orfanos: met her and talked to her. Talked to her about niacin and she said, oh no, I’m using niacin. And she said also that aronia berry, which is an herb,

Dr. Weitz: What’s it called?

Dr. Orfanos: Aronia berry, A R O N I A.  Can also lower LP little a I didn’t get a chance to research it but be something to look into as another.

Dr. Weitz: Yeah, I want to say [00:28:00] I think ortho molecular has a product that has that in it. Okay, they have some cardiovascular products that they have pioneered in the last few years. Yeah, they’re there.

Dr. Orfanos: They’re stepping up there. That’s good.

Dr. Weitz: All right. I’m do you ever test genetics? Thanks.

Dr. Orfanos: I check I’ll check MTHFR. Okay. To see if they’re methylating or not. And then I’ll, that kind of may or may not, it goes along with homocysteine. Homocysteine is high if the MTHFR is off. So sometimes that’s a clue.

And I’ll check I’ll check APOE4. I’m checking that more now. Why would you check on me? Because, like I say, it’s back to the forewarned, forearmed idea. If I know you got it, I’m going to be more aggressive in treating your risk factors so that you don’t get dementia and Alzheimer’s.

Dr. Weitz: Yeah. Dr. Houston helped develop a panel, a genetic panel through Vibrant America.

Dr. Orfanos: Cardia, CardiaX, I know. Yes. Yeah, that’s I [00:29:00] like that one too. I’ve done that even on myself. And that can also help direct you if you see if you have more cardiovascular risk genes, there’s one, I have some people with difficult to manage hypertension,

Dr. Weitz: right?

Dr. Orfanos: I have these, this one snip and that responds to an old and an old diuretic called amelioride. It’s been like, it’s 40 years ago, this thing came out.

Dr. Weitz: Oh, really?

Dr. Orfanos: And this just hits this epithelial sodium channel and eliminates the hypertension. People like they’re on four or five drugs.

And you put them on amelioride and slowly peel off everything else and pretty soon that’s all they’re on And that’s on that test, by the way.

Dr. Weitz: Oh, okay.

Dr. Orfanos: That’s cool wow, here’s a drug that’s just made for this condition,

Dr. Weitz: right?

Dr. Orfanos: And I thought that was neat.

Dr. Weitz: So now besides labs What are some of the other testing that you’ll use in your practice to assess?  coronary artery disease and cardiovascular risk [00:30:00]

Dr. Orfanos: Okay I’m limited here. I don’t have anything else. Yeah, but, when I what I learned about was another test called endopat. And that’s a a way to check endothelial function, slap a cuff on your arm and you blow it up till you cut off the blood supply for five minutes.  It sounds hard on you, but it’s not that bad. And then you have these little sensors in your finger, then you see how much you dilate your blood vessels when you release them, release the cuff and the blood, the better that is, the more resilient and healthier arteries are, and you can get judge your treatment by doing that.  Okay. That will be a nice tool to have.

Dr. Weitz: Yeah, I know Mark Houston uses that regulation.

Dr. Orfanos: Yeah, he does. Yeah, he does. Yeah. But again, you have to buy these things and ultimately, if you’re doing all these things, what I’m suggesting to do here with people, their endothelial function got better.  That’s that that, that should happen as part of the right treatment.

Dr. Weitz: As part of the endothelial function, do you [00:31:00] use nitric oxide stimulators?

Dr. Orfanos: I use I use one I used to use, there’s one that has a lot of beet juice, beet root juice in it. That’s a lot of oral stuff. Like the Neo 40.  Correct. Yeah, exactly. And now there’s one that Calroy makes it’s called Vascunox.

Dr. Weitz: Yes.

Dr. Orfanos: Works pretty good. It trip, it triples nitric oxide production. And which persists for 24 hours. So it’ll last the full day. So you just take two capsules once a day and that, that’ll crank up your nitric oxide production.  And if you’re hypertensive, it’ll lower your blood pressure, which is a lot of ways.

Dr. Weitz: I like now what about coronary calcium scans?

Dr. Orfanos: Yeah, I do them. I do them on just about everybody, for 49 bucks, you get a lot of information, meaning do you have calcium or not? That’s the information you get.

But sometimes you pick up aneurysms because they do a CAT scan of the chest, the aorta is [00:32:00] dilated, or you might pick up a nodule outside of the cardiac stuff. Use them routinely. And, if I have a 46 year old guy with coronary calcium, not a lot, but I should just, me. To be aggressive and for coronary calcium, it’s vitamin K two.

Yep. So that can slow coronary calcification and and increased bone mineral density. So it works, puts the calcium where it needs to go. And the aged garlic or IC is the brand, K-Y-O-L-I-C. And that was slow chronic calcification. The H garlic does is good for a lot of vascular things, endothelial function, stuff like that.

Dr. Weitz: And for the K2, are you using the MK4 or the MK7?

Dr. Orfanos: I use the MK7. That’s the one that I’ve been using. I know there’s some controversy over it, but that’s longer, longer lasting. And. I think has more efficacy.

Dr. Weitz: So what do we, since you mentioned those two, let’s say somebody, one of your patients has significant amount of plaque.[00:33:00]

Dr. Orfanos: Yeah.

Dr. Weitz: Do you have a plaque reversal program?

Dr. Orfanos: A K2 aged garlic, omega 3 fatty acids.

Dr. Weitz: How much k2?

Dr. Orfanos: I usually, I use at least 360 micrograms, if not more. 40 to 7 20. I just make sure they got plenty. Okay, box laid all those sites that need to be done like that. I just want to make sure I’m maxing it out.

Dr. Weitz: Some of the patients are nervous about vitamin K because they heard that vitamin K can be related to clotting.

Dr. Orfanos: Not you don’t get excessively coagulable by taking vitamin K, but this is K2. It’s that one that’s for coagulation. Even that, you can take a lot of that. They give people, big shots of it to reverse their coumadin and they don’t like clot up because they do that.

Dr. Weitz: Right.

Dr. Orfanos: So you’re it’s not a risk.

Dr. Weitz: Yeah. Yeah. I totally agree with you. I think the word on vitamin K is if you don’t have enough vitamin K, you won’t be able to clot, but once you have the needed amount, having [00:34:00] more is not going to make you clot more.

Dr. Orfanos: Now, if you’re on Coumadin or Warfarin, they’re called, it’s called a vitamin K antagonist.  That’s how you deplete vitamin K. You shouldn’t be taking vitamin K. Or if you do, you better balance it between the Coumadin dose and the vitamin K. Properly thinned, work it out with your doc.

Speaker: Okay what about a ct angiogram with artificial intelligence to assess soft plaque?

Dr. Orfanos: Yeah, I haven’t, I personally haven’t gotten into that.

It’s called clearly, yes. I think, okay, what would I do if I had somebody I’m just assuming people have some soft plaque. It’s not just all a little bit of calcium that I think they go together. That’s why the calcium was there in the first place because there’s some plaque rupture and which is soft plaque that’s gotten calcified.

So I, I would do what I’m doing. I think the possible plus is if you find somebody with a high grade blockage and doesn’t have any symptoms, [00:35:00] or maybe I’m just going to make an assumption. Then you might catch somebody at a, at the right time to intervene, but right.

Dr. Weitz: You might have somebody with a low coronary calcium scan and they think they’re home free, but if they have soft plaque is even more dangerous than hard plaque.

Dr. Orfanos: Yeah. Yeah. Because it can rupture. I think that’s right. That’s the connection. But if you got but, when you look at the literature, the more calcium in your arteries, the more likely you’re going to have an event, so it’s tied to that 49 really cheap test, and so that’s predictive.  I know it’s sexy to do the whole thing. And I can understand that. And I wouldn’t stop anybody from doing it, but I, but the more calcium you got, the more likely you’ve got coronary occlusion and, I’ll do stress tests on people and do stress echoes or nuclear stress on people with calcium scores.

And, then if it’s negative. Then I know for right now, they don’t [00:36:00] have obstructed seas granted, they can rupture plaque and all that, but if you’re doing all this other stuff you’re changing that risk, you’re moving that risk down. You wouldn’t have, you wouldn’t, let’s say somebody had vulnerable plaque and they were asymptomatic and had a normal nuclear stress.

Those people are low risk to have something happen in spite of worrying about worrying about vulnerable plaque, there’s still low risk. So that’s still, I still being a cardiologist in my mind here, what’s, what are the symptoms? What are my functional tests show?  And then I use the coordinate calcium score just to probably get me to the point where I’m going to do some testing or to inspire the, my patient to change. Hey, you got calcium, you’ve got to do something. Or, in 10 years, you’re going to be in some hot water, so I try to motivate them.

Dr. Weitz: That’s good. So what are some of the other lifestyle factors like exercise that can affect cardiovascular disease risk?

Dr. Orfanos: Sure. If you just, I tell my patients, you don’t have to, you don’t have to get a gym membership and, go to the, we’ll work out six days a week, [00:37:00] if you just get out and walk for 10 minutes, that 10 minute walk.

And that’s in the literature, 10 minute walk will lower your risk. It doesn’t take a lot. And that kind of gets people off the couch, let’s say, and gets them outside. And then, being in nature is actually healing in and of itself. So I get them to do that. I think resistance training, if you want, I think people need to go farther than that.

They need to do more than the 10 minute walk, but still that’ll help, but they need to do resistance training because they got to keep their lean body mass up because muscle is the currency of aging. Thank you. more, the more muscle mass you got, the longer you’re going to live,

you know, just, it’s not just all about falling.

It’s about the metabolic benefits. You’re a muscle, you’re not insulin resistant. You’re insulin sensitive when you got more muscle, but one thing, blood pressure is lower. The other thing is sleep, you’ve got to sleep. Sleep apnea is like overlooked a lot, nobody asks.

And those people with sleep deprivation, their [00:38:00] cortisol levels are high, they’re stressed out, their blood pressure is too high, they’ve got AFib, they’re they’re cognitively impaired. Just look for these things and, people will start to get better and better just by fixing these individual things.

for your attention. And they all work together for the best for the good.

Dr. Weitz: Do you give people a home sleep study?

Dr. Orfanos: I don’t, I, I think in my practice I just, I usually send them to these, one of these sleep center guys and they’ll work them up.  They know how to appropriately get Their tests covered, a lot of times I’ll do it and the insurance company goes you didn’t do the right diagnosis or rights.  So I looked in that way. I let them do it. I want them to get it done and to the sleep doctor to do it.

Dr. Weitz: Yeah, sounds good. So any other topics that we haven’t covered so far that you’d like to tell our listeners about?

Dr. Orfanos: I’ve got this one kind of little passion that I’ve come up with. It’s these it, there, there are these cell membrane [00:39:00] particles that are called plasmologens.

I don’t know if it’s new to me. But the plasmologens are in the cell membranes and they’re, there’s they’re 30 percent of your brain and your heart And they get depleted after you pass about 50. And that alone can lead to cognitive decline and cardiovascular disease and neurodegenerative diseases.

So these can be tested for and you can replace them with a with a supplement basically, by the way, exercise works and muscle building works, but you can take the precursor supplements and build them up. And

Dr. Weitz: What is the test for plasmoligins?

Dr. Orfanos: This one researcher, his name is Goodnow, G O D E N O W, Dan.

He’s a Ph. D. Canadian. He’s come up with a test that, that has, that can measure these and a bunch of other risk factors too. And he’s very scientific about the whole thing, yeah. Struggling to go through all this to learn all that he’s got to say, but the fact that you can, for instance, if your [00:40:00] plasmogens are low, and you’re an E4, an APOE4, and you get them up to like well repleted numbers, you can turn your risk of Alzheimer’s From a, from an APOE 4, which is a 30 percent lifetime risk.

If you got one to just the average risk of if you had three, three, it makes the four risk. You might say

Dr. Weitz: it’s I’m trying to think, I think I’ve heard something about this, is it some sort of a fatty acid type supplement?

Dr. Orfanos: Yeah, it’s a, it’s, there’s a DHA one. which is which is one of them.

And the other one that’s an omega three and the other one’s an omega nine supplement. It’s not olive oil. It’s not fish oil, omega threes are fish oils, omega nines are olive oils, more or less. But you take those precursors, he puts them on the right backbone. So when you eat it, it can get into your system and it gets incorporated into the paroxysomes, which are the little organs in the cells that make these plasmologens.  Ah, it’s.  It’s really cool. That’s all I can say. [00:41:00] I’m really

Dr. Weitz: what’s the company that makes a supplement.

Dr. Orfanos: It’s called Prodrome Sciences.

Dr. Weitz: Okay.

Dr. Orfanos: He named it because he thinks about the program of the disease. Before you get dementia, you’ve got the plasmodium deficiency issue that can be corrected. Huh.

Dr. Weitz: Interesting. Yeah. We’re all concerned about reducing the risk for dementia and keeping your cognitive faculties as sharp as possible as we age.

Dr. Orfanos: Yes, very much

Dr. Weitz: yeah, no, I’ve had Dr. Bredesen on several times. He’s his,

Dr. Orfanos: oh, yes, it’s

Dr. Weitz: brilliant.

Dr. Orfanos: Oh, I love the guy. And I that’s I tell him to read the, read his book, the end of Alzheimer’s program, the people with anything in cognitive decline or whatever, or the risk of it.  And and then I just started telling people, this is all fairly risk, like two months, two months old. This other thing with the plasmologists to read the other to read Dr. Brown. Good now’s book called Breaking Alzheimer’s, which is really pretty technical [00:42:00] reticence, easier easier on the lay persons and the doctor’s mind and the other guy but it’s the stuff’s there, the literature’s there, the studies and all that.

Dr. Weitz: That’s great. And of course, managing stress is super important for cardiovascular health as well.

Dr. Orfanos: Yeah yeah, the more stress you’re under the worse you do. You’re talking about cognition that goes down, cortisol levels go up, blood pressure goes up, blood sugar goes up. Oh there’s other things like a heart math.

You probably know, I don’t know about heart math, where it’s it’s trying to increase your heart rate variability. So we measure on monitors. We didn’t, and it turns out you can, that’s all you can change that by just practicing gratitude, feeling gratitude. So gratitude, appreciation, love, those positive emotions.  up your heart rate variability and guess what? Your blood pressure comes down your heart rate comes down you’re smarter, you do better on tests, your cholesterol [00:43:00] drops, your cortisol level it’s wow, one thing like that can do.

Dr. Weitz: So do you use heart math in your practice?

Dr. Orfanos: I do, this is more peripherally, I tell people about it more than I, I used to have these little devices and I have one at home where you you plug it into your iPhone, it’s a program and you click it on your ear and then you can measure your heart rate very, you can watch it go from red to green, red is like K, green is coherence,

Dr. Weitz: yeah, I measure it with the aurora ring.

Dr. Orfanos: The Oura ring does it? Okay. Okay. So yeah, it’s gives you an idea of where you’re at emotionally, psychologically.

Dr. Weitz: Absolutely. Yeah. It’s some cool wearable devices and they’re getting better and better. Yeah. All right. Great. Any final thoughts for our listeners and viewers?

Dr. Orfanos: You’re never too old to get better. So don’t let the years get in the way of you’re improving your overall health and. And [00:44:00] health span and probably lifespan.

Dr. Weitz: Absolutely. Dr. Ofanos, how can listeners get a hold of you?

Dr. Orfanos: You can contact us at Case Integrative Health, CASE, Integrative Health in Chicago.  And and through that website, you can get a hold of me and if you’d like to see me, I’d be glad to see you. So

Dr. Weitz: what’s the exact website?

Dr. Orfanos: It’s called, if you just Google case integrative health, it should pop up.

Dr. Weitz: Okay, great. And, and do you do remote consults as well?

Dr. Orfanos: Yes we do, but we, we see people in person for at least the first visit and once a year.

Dr. Weitz: Okay, great. Thank you.

Dr. Orfanos: You’re very welcome.

 


 

Dr. Weitz: Thank you for making it all the way through this episode of the rational wellness podcast For those of you who enjoy Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review.  If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. Some of the areas I specialize in include helping patients with specific health issues like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111. And we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.