Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Reversing Diabetes with Dr. Mona Morstein: Rational Wellness Podcast 78
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Dr. Mona Morstein discusses how to overcome Diabetes with Dr. Ben Weitz.

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Podcast Highlights

2:57  There are four or five main types of Diabetes:

  1. Type I is an autoimmune disease where a person’s own immune system attacks their pancreatic beta cells, and destroys it enough so that they cannot produce the insulin that the person needs to live. 
  2. Type II is the most common type and it is due to insulin resistance.
  3. Type 1.5 is Latent Autoimmune Diabetes of the Adult (LADA), which is type I that happens in people over 35, say generally 35 to 60 is where we see people getting a less intense type of type I, but can lead to the need for insulin.
  4. Gestational Diabetes, which is when a nondiabetic woman enters pregnancy, and then becomes a type II diabetic, generally due to gaining too much weight during the pregnancy
  5. MODY, mature onset diabetes of youth, which is diabetes because of gene defects, like when the beta cell produces insulin, but lacks a good gene to secrete it, or a cell doesn’t genetically have a good receptor.

5:34  Type II diabetics if poorly controlled or poorly managed, the high blood sugars cause oxidative damage that can destroy their pancreatic beta cells and these patients end up needing insulin, like type I diabetics.  And most diabetics are not properly controlled. 75% of type II diabetics do not get their HgA1c below 7 as recommended by the American Diabetic Association. And type I diabetics, if they end up injecting too much insulin in order to try to control their blood sugar–say 100 to 200 units a day–can develop insulin resistance like type II diabetics. Normally our bodies secrete between 30 and 40 units of insulin per day, so 100 units is a lot. The reason so many diabetics are poorly controlled is that we are only using a big pharma approach based around medications.  We need to use diet, exercise and lifestyle approaches to control blood sugar.  And most of the drugs do not directly affect insulin resistance, except for Metformin, which deals a little with insulin resistance. But Metformin’s main job is to decrease the liver’s production of glucose. The TZDs like Actos and Avandia were directly affecting insulin resistance, but they are not in broad usage because of all their side effects. The 2nd most common category of drugs for diabetes are the sulfonylureas, like Glyburide and Glipizide, which can cause weight gain, hypoglycemia, and they can aggravate insulin resistance. They also don’t significantly reduce the HgA1c. The DPP4s like Januvia lower the HgA1c at the highest dose say 0.5%, but a low carb diet can take someone who’s at 10 and lower them down to 6 in 3 months. There is no drug that can do what diet, exercise and lifestyle changes can do, what a Functional Medicine approach can do.

13:30  With type I Diabetes you have a gene that can turn on and give you type I Diabetes and then we have to look at what factors might turn this gene on.  These could include gluten, dairy, vaccine, environmental toxins, family stress and nutrient deficiencies.  Finland has the highest rate of type I Diabetes and they have done studies showing that giving newborns vitamin D and fish oils reduces the onset of type I.  Celiac disease can lead to type I diabetes.  Leaky gut seems to precede type I diabetes in many kids, so the gut is an important factor. 

26:16  When it comes to type II Diabetes, eating refined sugar, refined grains, junk food, and fast food and lack of exercise are important causative factors.  But Dr. Morstein also believes that saturated fat intake can play a role in worsening insulin resistance. If you are getting too much saturated fat without omega 3 fats to offset it, this will make diabetes worse. Here is a reference: Dietary fat, insulin sensitivity and the metabolic syndrome.

30:06  The lab testing that Dr. Morstein recommends for patients with diabetes include the following:  

  1. CBC
  2. Chem screen (liver, kidneys, etc.)
  3. Ferritin, which is the best early sign of fatty liver.
  4. Fasting glucose, HgA1c C-Peptide, which tells us how much insulin your pancreas can secrete, insulin (as long as they haven’t injected insulin)
  5. GlycoMark is a test that gives you a better idea of blood sugar control than HgA1c because it picks up blood glucose excursions better.
  6. HsCRP for inflammation
  7. Testosterone in guys.
  8. Red Blood Cell magnesium and zinc.
  9. Fibrinogen to see how clotty they are.
  10. Random Microalbuminurea through urine to pick up early, early liver damage

 

35:05  The best diet for Diabetes is the low carb diet and two of the most well known advocates for this are Dr. Richard Bernstein and Dr. Richard Feinman and here is a paper that they were among the authors of: Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base.   There is another approach that has evidence to show that it is also effective for diabetes, the Macrobiotic diet, which was demonstrated in the Ma-Pi2 study: The Macrobiotic Diet for Diabetes. Dr. Mornstein feels that for most patients, the low carb program will work better. She does think the low carb diet can include nuts and 30-40 grams per day of carbs, but no grains or legumes. She does not think you have to do keto, which is very, very low carb and harder to follow. Dr. Morstein thinks you can include some muffins or bread or pancakes made from almond flour. and she advocates including at least 5-10 grams of fiber powder to make up for the lack of fiber in a low carb diet.

40:34  Dr. Mornstein recommends not snacking between meals in contrast to some nutrition programs that advocate having a small meal or snack every 3 hours to maintain a stable blood sugar. The human organism easily has the capacity to not eat for 5 hours and that way you let your body rest from having to process foods. And this lets the liver and the digestive system rest.

46:00  Dr. Morstein recommends certain supplements for patients with diabetes, including a good multivitamin and mineral, like one that might require taking 6 capsules per day.  Taking a one a day multi may be a waste if the nutrients are not found in therapeutic dosages.  Dr. Morstein mentioned that she is big fan of fish oil and she is not a big fan of krill oil because each capsule contains fairly small levels of EPA and DHA, the active ingredients, such as a total of only 50 mg of EPA and DHA combined in a capsule. To get a therapeutic dosage of say 2000 mg of EPA and DHA would require taking 40 capsules per day. It’s a joke!  Dr. Morstein designed a proprietary formula made by Priority One called Diamend that includes therapeutic levels of nutrients that can benefit diabetics, including Zinc, Chromium, Berberine, R-Apha Lipoic Acid, Gymnema extract, Benfotiamine, Bilberry, NAC, Green Tea Extract, Turmeric, and Vanadium (4 capsules taken after breakfast and 3 capsules taken after dinner). With respect to Lipoic acid, if you take R Lipoic acid you get twice the amount of the active ingredient than if you take just Lipoic acid, which is a combination of the R and the S isomers, but the S form is not active in the body. An elevated HgA1c is causing oxidative damage to the body, so taking the proper anti-oxidants can prevent some of this damage, such as R Lipoic acid and NAC that can provide antioxidant protection, reduce insulin resistance, and also support the liver.  Berberine is a great herb that is comparable to Metformin and also supports the liver. Benfotiamine is the fat soluble form of thiamine (B1) which can prevent damage to the nerves, the kidneys, and the eyes, at a dosage of 450 mg per day. The Burmannii or Indonesian type of cinnamon is a helpful supplement that if taken in capsules at bedtime can help to lower their morning glucose at a dosage of 1000 mg per day. Fat cells in the stomach region can make tumor necrosis factor alpha that causes insulin resistance and curcumin can help to decrease the inflammation and help with insulin resistance. Curcumin can also help rpotect the brain and reduce the risk of developing Alzheimer’s.  Gymnema sylvestre is Dr. Morstein’s favorite botanical and it has been shown to help the pancreas produce insulin again, and it also reduces cravings for sugar. If you are going to a holiday party, bring some gymnema sylvestre and swish some around in your mouth and it will reduce your craving for sweets.

 

 



Dr. Mona Morstein is a board-certified Naturopathic Doctor who is practicing Functional Medicine at the Arizona Integrative Medical Solutions with a focus on treating patients with obesity, diabetes, thyroid, hormonal imbalances, and gastrointestinal disorders like SIBO and IBS. She is the author of the best-selling book, Master Your Diabetes: A Comprehensive, Integrative Approach for Both Type I and Type II Diabetes. She is the founder and executive director of the Low Carb Diabetes Association. Her website is Arizona Integrative Medical Solutions and Dr. Morstein is available for telemedicine.

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.



 

Podcast Transcripts

Dr. Weitz:                            This is Doctor Ben Weitz with the Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to the Rational Wellness Podcast on iTunes, and YouTube, and sign up for my free ebook on my website by going to doctorweitz.com. Let’s get started on your road to better health.

Hello Rational Wellness podcasters thank you so much for joining me again today, Doctor Ben Weitz, here, and for those of you who enjoy listening to the Rational Wellness Podcast, please go to iTunes and give us a ratings and review, so more people can find our Rational Wellness Podcast. Our topic for today is diabetes and prediabetes, which are epidemic and increasing in the United States and around the world. 9.4% of adults in the US are diabetic, and in some states as many as 15%. This equates to about 30 million Americans with diabetes, and somewhere around 90 million with prediabetes, and these rates are climbing among children and teens.

One out of three Americans have diabetes or prediabetes, and 90% to 95% of these are type two diabetes, which are caused by diet and lifestyle. Rates are even higher among certain populations among American Indians, blacks, Hispanics, and Asians, and among whites. This paralleled by an increasing shocking rates of obesity and being overweight with about 70% of the US population being overweight or obese. Of course, these numbers are pretty much paralleled by the rest of the world especially as we spread our American lifestyle around the globe.

I’m happy to have Dr. Mona Morstein to join us today to give us some information. She’s a naturopathic doctor from Tempe, Arizona, who’s practicing functional medicine at Arizona Integrated Medical Solutions with a focus on treating patients with obesity, diabetes, hormonal imbalances, and gastrointestinal disorders like SIBO and IBS. She’s the author of the bestselling book, Master Your Diabetes: A Comprehensive Integrative Approach for Both Type I and Type II Diabetes. She’s also the founder and executive director of the Low Carb Diabetes Association. Mona, thank you so much for joining us today.

Dr. Morstein:                    Thanks very much. Ben, I really appreciate it.

Dr. Weitz:                         I’d like to begin the discussion by talking about the different types of diabetes, and the distinctions between these.

Dr. Morstein:                    Yeah. There’s kind of four or five main types, there is type II diabetes, which is the most common type is due to insulin resistance where usually early on at least for sure people can make insulin but their cells are no longer responding to the signals to take glucose in, and like you said there are a number of reasons the cells don’t respond. Obesity being one of them, but there are other factors involved, as well. Type I diabetes is an autoimmune disease where a person’s own immune system attacks their pancreatic beta cells, and destroys it enough so that they cannot produce the insulin that the person needs to live.  There’s gestational diabetes, which a nondiabetic woman enters pregnancy, and then becomes a type II diabetic, generally due to gaining too much weight during the pregnancy. There’s MODY, a mature onset diabetes of youth, which is diabetes because of gene defects, like the beta cell produces insulin, but lacks a good gene to secrete it, or a cell doesn’t genetically have a good receptor. Then the last is type 1.5, Latent Autoimmune Diabetes of the Adult (LADA), which is type I that happens in people over 35, say generally 35 to 60 is where we see people getting a less intense type of type one, but they can still for sure lead to full need of insulin.

Dr. Weitz:                         Yeah. Type 1.5, right? I never heard of that, before.

Dr. Morstein:                    Yeah. Type 1.5. Yeah.

Dr. Weitz:                         Interesting. I think there’s some confusion among the general public, I’ve heard people discuss diabetes and say that type twos become type one-

Dr. Morstein:                    Yeah. Right. Yeah. We have a couple things. One, we have a lot of patients who are adults getting type two, very commonly misdiagnosed as type two, and there’s a very simple blood test that can be done. We do have some lean type two patients. You will see lean, so we have to make sure is it really type two, or do they have LADA. Now, the type two becoming type one, so if you are under poor care and/or are not making changes you need to reverse your type II, if you have bad control of your type II, the damage that these high blood sugars can cause over the years can affect the pancreas as well as eyes, kidneys, nerves, and heart, you know the blood vessels, and so people can kind of destroy their pancreatic beta cells and this oxidative damage from poorly controlled diabetes, and then as a type II need to be on insulin, like a type I.

Dr. Weitz:                         Right. Then type Is can also have concurrent type II, if they’re poorly controlled?

Dr. Morstein:                    Yes. I’ve seen type I’s coming into my office that are injecting a 100 or 200 units a day, so for a nondiabetic, say for not a lean, but a normal weight nondiabetic, so we make maybe around 30 to 40 units of insulin a day, for whatever we eat, or drink, or whatever. If you have someone walking in the door, and they’re injecting a 100 units a day to control their blood sugar, that’s going to cause insulin resistance.  That’s way above the physiological norm of what the body is designed to have in it all the time, so you can get type Is that have insulin resistance. Now, a type I is going to develop insulin resistance when their blood sugars go over about 170 anyway, just high blood sugar can make them insulin resistant, so that is a part of it, but it’s not the core nature of their condition, which is the autoimmunity.

Dr. Weitz:                         Right. It’s amazing, though, the patients that I’ve seen how many are poorly controlled, the kids they really don’t want to prick their finger, they don’t want to test their blood sugar, it’s a pain, and the type II a lot of them are in denial, or just think everything’s okay, and they don’t want to test regularly, so I don’t know what the percentages are, but it seems like a lot are uncontrolled, or poorly controlled.

Dr. Morstein:                    I know the last statistics we really have in that regard, you know, from 2002 to 2006 where almost 75% or so of people couldn’t get below seven-

Dr. Weitz:                         Wow.

Dr. Morstein:                    Which is the ADA guide. 

Dr. Weitz:                         On the hemoglobin A1C. Yeah.

Dr. Morstein:                    There’s a significant generally 50 to 60, to sometimes 70 depending upon the study do not obtain at least what they consider the three ADA goals, which is an A1C less than seven. LDL’s less than a 100, and blood pressure less than 130 over 70, so we have very bad goal reaching in our country, and a lot of it is of course due to the obvious, that it’s a big pharma based treatment, that it’s drugs, and those with type II there’s only one drug really that was designed to deal with insulin resistance, and that was the TZD’s, which because of a lot of problems with them have essentially gone off the market. I mean, you can use them, but-

Dr. Weitz:                         What drugs would those?

Dr. Morstein:                    Those were the Actos and Avandia type drugs.

Dr. Weitz:                         Okay.

Dr. Morstein:                    Right? Now, Metformin deals a little bit with insulin resistance, but it’s not it’s main job, which is to decrease livers production of glucose, so you have a disease of insulin resistance, and essentially no medications out of the huge list of medications that they give patients that actually deals with insulin resistance, they’re all just about clear the glucose out of the bloodstream, and the way they do that can actually cause quite a number of problems in patients.

Dr. Weitz:                         Why is that? I guess they’ve just been unable to develop a drug that controls insulin resistance.

Dr. Morstein:                    Yes, or that controls insulin resistance, but again you’ve got it also might cause this or that damage. Right?

Dr. Weitz:                         Right.

Dr. Morstein:                    Drugs have side effects, many of them, we’re lucky with Metformin that it’s just some gastrointestinal distress, and doesn’t really cause anything else.  But some of these other drugs, the second most common one, the sulfonylurea’s, they cause weight gain, they can aggravate insulin resistance. They can cause hypoglycemia, significantly. They’re all just designed to clear the glucose-

Dr. Weitz:                         By the way, what drugs are included in the sulfonylurea?

Dr. Morstein:                    Sulfonyurea’s are like glyburide, which is the worst for causing hypoglycemia. Glyburide, Glipizide, so those kind of drugs, but they’re cheap. They’re going to be by conventional care, another drug to use, but they have problems. Right? Also, many of them don’t really significantly reduce the A1C’s very much, like the drugs like Januvia, the DPP fours, they may lower the blood, the A1C in three months at the highest dose of maybe 0.5% where a low carb diet could take someone who’s at 10 and lower them down to six in three months. The diet, and the lifestyle there’s no drug that equals the amount of improvement that just what we’re trying to do on this naturopathic, or functional level can do. Right?

Dr. Weitz:                         Right. But that word doesn’t seem to have gotten out.

Dr. Morstein:                    Yeah. Well, you know the ADA acknowledges there is a low carb diet, it’s not like they’re saying, everybody should be on it, and then now they’re approving bariatric surgery for people who can’t get their A1C’s under control, but they can’t just come out and say, hey, everybody, you guys, everybody, really just do the low carb diet.

Dr. Weitz:                         Right. Yeah. They’re still recommending whole grains, and a low fat diet.

Dr. Morstein:                    Well, you know, I went to the ADA site, and you know I will say there’s a lot of good things about the American Diabetes Association.  For one thing, they devote a lot of money to research, and they have also, if you’re a fireman, and you’re a diabetic, or you’re in school, and you’re a diabetic patient they’ve paved the way for the rights, the civil rights, and the working rights that people with diabetes in our country.  However, to become a sponsor in the ADA you have to drop at least a $100,000.00, that’s the lowest level.

Dr. Weitz:                         Wow.

Dr. Morstein:                    You know, who aside from drug companies can be supportive of the ADA?  That’s their funding.

Dr. Weitz:                         Yeah. Let’s talk a little bit about type I diabetes.

Dr. Morstein:                    Yeah.

Dr. Weitz:                         What are some of the most common triggers?  A lot of people have talked about milk products–dairy sensitivity–as being one of the triggers. Can you talk about that?

Dr. Morstein:                    Well, here’s the deal, obviously the number one cause of type I diabetes is you have a gene that can turn on and give you type I diabetes.

Dr. Weitz:                         Right.

Dr. Morstein:                    It starts from you just randomly got this gene. Then what might be factors turning on the gene?  Well, you know I go through things with every patient, and there’re questions on vaccinations on gluten, on dairy, on environmental chemicals, on stress in the families, on nutrient deficiencies. The Fins, Finland, had the highest per capita onset of type I diabetes, and they’ve done studies where giving new born vitamin D and fish oils reduced the onset of type I in those populations compared to the kids that didn’t get those supplements.  What is it individually that affects each child, who knows? We have a lot of kids drinking milk, and they’re not getting type I, so we can’t say, oh, my goodness. I will say this, I read a good article, a study saying that with, you know, for me, as I note in my book, if we could identify kids with celiac disease early on, right away, and we got them off of gluten their risk of developing type I would go down about to zero.

Dr. Weitz:                         Wow.

Dr. Morstein:                    We’ve got all these pediatricians giving them antibiotics of their ears, or vaccinations whatever, but we need to get them to screen every child who’s now eating gluten, because you have to be eating gluten, so toddlers, a two year old, right, test them for celiac disease before potentially it’s unknown and then we get kids developing type I diabetes since those two are so connected, but-

Dr. Weitz:                         By the way, what’s the proper test for celiac?

Dr. Morstein:                    The proper test with celiac in a child is you can do a stool sample for toddlers. Right? There’s also a blood test, a pediatric blood test, but people, you know, you have to be eating gluten every day, like equivalent of about a piece of bread for at least three to four weeks before the test, otherwise we can’t see if there’s celiac disease. 

Dr. Weitz:                         Unless you do an intestinal biopsy.

Dr. Morstein:                    Well, they’re going to do that after the blood work.

Dr. Weitz:                         Right.

Dr. Morstein:                    Yeah. We’ve got a lot of kids, I see kids, they never had a vaccine, parents, they’re a very loving family, there was no stress, like a pet dying, or grandma, God forbid, they don’t spray environmental, they don’t have an exterminator come into their house, or outside, and you’re just like, why did this happen? We just don’t know. We can’t identify it on each individual.

Dr. Weitz:                         Right. I notice in your book you mention the A1 milk being more problematic than A2 milk?

Dr. Morstein:                    Yeah. I think most people understand, or not most people, but milk in America, that A1 milk is from cows that have a different amino acid basis to the protein molecule of milk, and that is more allergic in humans versus many other countries in the world use cows that make what’s called the A2 milk that has a different amino acid, it’s very less reactive. Our milk is why we certainly see many people have at least a cows milk sensitivity, which can be a lot of mucus, and sinus, and asthma, or it’s the number one food that causes GERD, reflux, even without mucus, it just goes right to the stomach. Those are from the allergy to the milk protein.

Lactose intolerance, you just can’t you just can’t digest the lactose, that would be A1 or A2, but in terms of allergic to milk, and there are some connections if you have that allergic to milk, there are some similar proteins on the pancreatic cells, so if the immune system is kind of attacking the milk, and it could get confused and maybe attack the similar proteins on the pancreas.

I do want to mention one thing, though, when we talk about food sensitivities, or just in general we’re talking about often times leaky gut, and what’s interesting with leaky gut is that when kids have diabetic antibodies, but are not yet showing the disease they pick up an upregulated Zonulin, they show leaky gut in these kids. Another reason people might get type I is a virus getting through the gut wall, and then attacking the pancreatic beta cells, and causing damage to them, so we look at the gut quite a lot, and if you’re getting into food sensitivities, we’re going to think your gut is unhealthy, as well, since it all comes from the gut, but leaky gut seems to precede type I diabetes in many kids.

Dr. Weitz:                         That’s interesting, because we heard about the research from Alessio Fasano, who talks about this triad of autoimmune disease where you have a leaky gut, and then you have gluten, and then you create this upregulated immune system and that sets up the potential for autoimmune disease.

Dr. Morstein:                    Yeah. Although, I will differ in one regard, I know there’s a very big anti-gluten, anti-dairy, but for those of us like myself who does a lot of food sensitivity testing, you know some people are sensitive to corn, and some to soy, and some to eggs, and some to almonds, and I think before we just pull everybody, and not everybody actually reacts to gluten. I really think that we should always strive to do very individual care with the food sensitivities and really see what does this patient, what does their body reacting to?

Dr. Weitz:                         One of the problems is these food sensitivity testing is so problematic.  Sometimes you do a test, you seem to get reasonable results, and then you do a test and nothing comes up except clams, and some other bizarre food, which they’ve never eaten, and now you spent all this money for this test, and nothing comes up, or-

Dr. Morstein:                    I would say there are-

Dr. Weitz:                         Or you do a test and everything comes up.

Dr. Morstein:                    Everything coming up, obviously, is a-

Dr. Weitz:                         Leaky gut.

Dr. Morstein:                    Sign of leaky gut, but I think there’s a lot of labs doing food sensitivity, but I know the lab I use, I’ve flown out there, I visited their lab. I can verify the one I use for the last 16 years, which is Alletess Labs at foodallergy.com, they must have got that right at the beginning. I mean, I can verify their consistency with truly finding what people seem to be reactive to, and if people have a lot of foods, you know, the idea with food sensitivities you take them all out the first month, start healing their gut with the supplements, and then they come back in a month, then they should be significantly better, and then you can start adding the foods back in. Nobody has to be off all of these foods for a year, or two, or whatever. It’s an indication of something needs to be healed, but guts heal from leaky gut enormously quickly when the irritant is removed, because they’re so vascularized.

Dr. Weitz:                          Yeah.

Dr. Morstein:                     Yeah.

Dr. Weitz:                          I just want to point out, I just had a discussion with Cyrex where I had one of these tests come back where there was nothing tested, and they said, from now on we can include a total IGG with the test at no additional cost, and that way you can tell if the person’s immune system just isn’t working well, and they’re total IGG is suppressed then they can factor that in, and recalculate the results, and-

Dr. Morstein:                     I guess there’s also cheaper tests than Cyrex.

Dr. Weitz:                          You mentioned vaccines as triggers.

Dr. Morstein:                     Yeah.

Dr. Weitz:                          As possible triggers for type I diabetes

Dr. Morstein:                     Possible.

Dr. Weitz:                          And I noticed in your book you mentioned giving the kids some supplements to help with their immune system like you mentioned vitamin D, and echinacea, and milk thistle.

Dr. Morstein:                     Yeah. When I was in medical school we had a pediatrician come in and say, “Hey, when I have to give vaccinations I’m boosting their immune system a couple days before, during, a couple days after.” Then obviously it made great sense to us, because we don’t usually get exposed to viruses by injection, we breathe them in, and then it takes days for the process to happen, so it’s a little bit of a shock to the immune system. I think giving NAC, you know, there are kids that maybe can’t make glutathione, that might get, as well, they might get some nerve damage.

I do a product called Immugen from a company called Progena, because it’s glycerine, kids love it, it’s a great immune system booster, and D, and maybe some Liposomal, now, I give glutathione, because kids can’t really take, obviously, an NAC capsule, and it’s nasty flavor wise, so by giving some ways to support antioxidant status, immune status, it can really, I hope, seem to boost things in the kids, so they don’t have a really serious reaction against not only just against the vaccination, but the liver as just part of the excipients, but I have a good website where the CDC lists all the excipients in all of the vaccinations, and so-

Dr. Weitz:                          Yeah.

Dr. Morstein:                     That’s what we’re trying to have the liver clear better-

Dr. Weitz:                          Right.

Dr. Morstein:                     It’s that junk that it comes with, you know the virus that they’re injecting.

Dr. Weitz:                          Yeah. The World Health Organization actually recommends giving 200,000 IU’s of vitamin A prior to the MMR vaccine.

Dr. Morstein:                     Yeah. They came out 25 years ago saying they’re very much into 2,000 units of vitamin A, also for treatments, if someone has measles they said, “Hey, give them a 100,000 vitamin A,” as this huge immune booster. I’ve used that in many conditions in toddlers that were pretty sick. Of course, I do it maybe for three days, or four days, but vitamin A is cheap and the World Health Organization can use it in rural villages, it’s easy. It’s a huge immune booster. I would just give a clinical pearl, don’t give it all at one time, if it overwhelms the kid, they can have a really nasty headache, so you want to break it up into several doses throughout the day, and that should stave off the headache that can last for a few hours with acute elevated vitamin A.

Dr. Weitz:                          Yeah. I never liked the idea of giving one huge bolus, the same thing with the 20,000, or 50,000 injectable vitamin D, it seems to make so much more sense to give 5,000 or 10,000 a day over the course of a week than give them a 50,000 unit shot.

Dr. Morstein:                     Yeah. Shots are a little rough, anyway.

Dr. Weitz:                          Yeah.

Dr. Morstein:                     With vitamin D, it’s oily. 

Dr. Weitz:                          Moving on to type II diabetes, and-

Dr. Morstein:                     Yeah.

Dr. Weitz:                          Mechanism for type two. Most of us are aware of the fact that eating sugar, and lack of exercise are some of the main factors, because we got this rising blood sugar, and insulin resistance, but I read in your book that you also said that increased saturated fat intake can play a role.

Dr. Morstein:                     Yeah. I mean, I know there’s a lot of ketogenic, and et cetera, Paleo people out there, but the science is pretty clear that if you are getting too many saturated fats and I believe it’s too many saturated fats unopposed by a good amount of omega three fats, so omega three fats lower insulin resistance. Saturated fat, if you’re getting too many they can absolutely worsen insulin resistance.  The idea is not that you can’t eat saturated fats, but that we have got to make sure people are getting into their diet a balance of omega three oils, for sure. If you get even with meat, if you get grass fed, grass finished organic meat, half of that is essential fatty acids, but if you’re getting it, you know, you’re just lazy, or you’re going out to eat a lot, that’s feed rot meat, that has no omega threes, after 90 days of being fed grains, that meat has no omega threes left in it, so this can be throwing people off with their oil balance.

Dr. Weitz:                            Interesting. Yeah. It’s true with the Paleo movement, and the ketogenic movement there’s a big push for saying that saturated fat is perfectly fine, and a lot of people are sort of like, can it really be fine? Should we really have as much butter as you can consume? Then of course, there’s the fat with sugar problem. You know? That I think Mark Hyman calls sweet fat, which is that’s really a bad combination is when they’re eating junk food, and they’re getting the saturated fat with the high glycemic carb, sugar combination.

Dr. Morstein:                     Yeah. I mean, it’s certainly refined sugar, refined grains, junk food, fast food, but if you just want to overeat anything, gluttony, unfortunately is whatever you’re overeating to gain that abdominal fat is going to be a problem, and of course the problem with insulin resistance is once it sets in insulin is one of the hormones that tells your brain I’m full, I’m done, that’s enough, you know, that’s it, I don’t need to eat more, and you can get that insulin resistance in the brain can tell people I’m still hungry, I still want food.

It’s not lack of willpower, it’s literally our appetite is driven by chemicals and hormones, and when they’re thrown off we’re just not going to get signals that I’m done, that’s enough, walk away from the table. Once people get on a low carb diet in a week, they’re like, “Oh, my God, it’s easy. I can just eat a piece of fish, and this, I’m full,” because that can settle down in their brains very quickly through food when we get that under control. Whatever you’re overeating to become overweight, or drinking, of course, soda pop, you know, energy drinks, these sugary, sugary things they’re just really some of the worst. Right?

Dr. Weitz:                          Yeah. Even Gatorade-

Dr. Morstein:                     Yeah.

Dr. Weitz:                          And some of the things people think are healthy. When it comes to lab testing, what labs do you like to run for patients with either prediabetes, or diabetes?

Dr. Morstein:                     Obviously, people need to have their yearly with the liver, and kidney, and glucose, and the lipids, and their CBC. I always include ferritin, which is not standard on labs, not just ferritin, has three different roles in the body. One is storage of iron. Two, we store it when there’s a bacterial infection, a serious bacterial infection, and three is acute phase inflammatory marker, and if we have a type two who’s got elevated ferritin while you do maybe have to rule out a condition called, hemochromatosis, which is a genetic hyper absorption of iron from your food, mostly these people have fatty liver, and so we need to do an ultrasound of their liver, and we can pick up fatty liver. That really drives insulin resistance, and fatty liver is the number one chronic disease of the liver in our country, today, and can cause the same kind of fibrosis and cirrhosis that alcoholism does.

Dr. Weitz:                          And truly caused by sugar and high glycemic carb intake. Right?

Dr. Morstein:                     It’s just caused by too much fat, really, whatever caused the fat. It’s the abdominal fat will then go and get to the liver, and cause the liver to have now too much fat in its cells. Of course, an A1C, a C-peptide, so you can draw insulin to see how much insulin they make as long as they’ve never injected insulin. As soon as someone’s injected insulin, that you can’t measure it anymore, it’s an inaccurate reading, because as soon as you inject insulin you’ll make insulin antibodies, so C-peptide is the part of the insulin molecule that breaks away from it for it to actually form insulin, so they’re equal.  There’s one C-peptide for one insulin, but we never make antibodies to C-peptide.  That tells us what is your pancreas able to produce in terms of insulin.  There’s another test called GlycoMark, which is a 1,5-AG substance that helps us look at excursions, and sometimes interpret the A1C better, because you can have an A1C at six, because you’re having lows all the time-

Dr. Weitz:                          By the way for those who don’t hemoglobin A1C is believed to be a three month indicator of blood glucose levels.

Dr. Morstein:                     Yes.

Dr. Weitz:                            Right?

Dr. Morstein:                     A1C is our monitor, how you’re doing longterm. It could the same number of A1C can be there if you’re under good control, or if you’re just going up and down all the time, so the GlycoMark can help us interpret that. I do vitamin D, we might need to check thyroid, we might need for guys, we might want to check their testosterone levels, there’s just maybe some red blood cell magnesium, red blood cell zinc, these can be low in people with diabetes. I would want to do an HsCRP, which is a monitor of inflammation that’s related to cardiac disease, and a fibrinogen to see how clotty they are, just because people with diabetes type II, well, if it’s not well controlled have a very high increased risk of dying of cardiovascular disease, which is basically what they usually die from. These are broad base labs that we’ll want to do.

Dr. Weitz:                          Cool. Do you include adiponectin and leptin in your labs?

Dr. Morstein:                     I don’t. I don’t do either of those.

Dr. Weitz:                          Okay.

Dr. Morstein:                     For one thing, leptin, you know there is a leptin resistance, or adiponectin, those are going to be fixed when fix their weight, so to measure them we don’t really have any specific ways, I feel, that’s really effective in that, and those will readjust once the insulin resistance is settled down.

Dr. Weitz:                          Cool.

Dr. Morstein:                     One other lab, the Random Microalbuminurea that’s a good urine test to pick up early, early liver damage, before it shows up in the lab work. No, I don’t measure those hormones.

Dr. Weitz:                          Okay. Cool. Let’s talk about treatment.

Dr. Morstein:                     Yeah.

Dr. Weitz:                          What type of diet is best for diabetics, and prediabetes?

Dr. Morstein:                     Doctor Richard Feynman and Doctor Bernstein, Richard Bernstein and 25 other physicians, or researchers came out with an article that was printed in Elsevier Journal on that a low carb diet is the premiere treatment for people with type two diabetes.  https://www.sciencedirect.com/science/article/pii/S0899900714003323 Actually, other researchers just came out showing that type one diabetes pediatric patients were improved on a low carb diet, plus a thousand other studies. Now, you’ve got two, you do have the MaPi2 study, which show that people on a macrobiotic diet, that was higher carbs, but no animal fat at all, no real oils at all, actually was very significant in uncontrolled type two diabetic men at really reducing everything we wanted to have reduced. The Macrobiotic Diet for diabetes study. You get some people that are saying, you know, a plant based diet, higher carb, but for most people it’s got to be low carb.

In our society, honestly, people are going to thrive much better in our society, and be able to socialize and eat out, and on a low carb diet then they will on some macrobiotic diet. Now, the low carb can be what I call the omnivore low carb, where you eat some meat, and fish, and some organic soy, and you make things out of nut flours, and coconut, and eggs, just all around variety, you eat nuts, or there’s the keto aspect, which is very, very low carb, or there’s actually a vegan type of low carb, and then there’s an ovo-lacto vegetarian type of low carb.

Dr. Morstein:                     For my patients, in reality, most of them don’t want to do keto, and I don’t make them, and I don’t think you need to, but they do that 30 to 40 grams a day of carbs, which will work very well for almost everybody, but it gives them a little more food to eat, you know, almond muffins, or pancakes, and things that make life more enjoyable for most people eating low carb.

Dr. Weitz:                          Do you let them include any whole grains, or legumes?

Dr. Morstein:                     No. I don’t. No, the grains, you can’t, no, you can’t do any grains.

Dr. Weitz:                          What about legumes?

Dr. Morstein:                     Yeah. Legumes, no, you can’t, now, every now, and then I have a couple patients who are in really great control, and if they have a couple tablespoons of hummus, because there’s got oil in it, and it’s got the garlic in it, they say that a little hummus doesn’t bother them. Okay. No, beans and grains, and potatoes, and sweet [crosstalk 00:38:29]-

Dr. Weitz:                          Beans are so high in fiber. Right?

Dr. Morstein:                     Yeah.

Dr. Weitz:                          And their glycemic index is in the 20s.

Dr. Morstein:                     You would think with the beans it would work, but for my patients eating beans, you know, they’re going to go up now, they might come down just after an hour or two, say, but it’s tough. The beans are incredibly high in fiber, in fact that’s for a nondiabetic patient, I’m not an advocate of keto, or Paleo at all, and there are studies where these changes in the microbiome by not eating grains, or not eating beans in nondiabetic patients just as a general diet are devastating to the microbiome, because the microbiome, the beneficial bacteria eats fiber.  When we take out these great sources of fiber, we change the bacteria, we start making less short chained fatty acids, and that’s not a good thing for colon cells, or even systemically. On a low carb diet I’m very adamant that my patients have to add fiber powder back in. If you’re on low carb, you’ve got to be getting at least five to 10 grams of fiber powder in a day to make up what we’re taking out, because vegetables just really won’t do it enough.

Dr. Weitz:                          Yeah. Of course, whole grains are also high in fiber, too, which that makes it harder to get the fiber.

Dr. Morstein:                     Yeah. I mean, for people that are nondiabetic to eat whole grains, and to eat beans I am an advocate of that, as well, for sure, but once you become a patient with diabetes they just can’t do it anymore, so at least with supplements we’ve got to replace both water soluble, and water insoluble that balance of fiber at least into the diet while having to eat healthy diet, or otherwise.

Dr. Weitz:                          I notice you recommend no snacking, and for years we’ve always recommended snacking, you don’t want to go to long, or your blood sugar will dip, so every two to three hours you have to have some food in your system to keep an even blood sugar, and that theory seems to be gone.

Dr. Morstein:                     I have from day one in medicine, which is about 30 years ago, I’ve always been an anti grazer, even for hypoglycemia you have to eat many meals throughout the day, that’s called enabling the condition-

Dr. Weitz:                          Yeah, but grazing is different than snacking, like say, here I’m going to have 12 almonds as a snack, or something at 3:00.

Dr. Morstein:                     I mean, if you just want a snack, but the question is that the human organism easily has the capacity to not eat for five hours. I eat a breakfast, and I go hike 10 miles without eating, that’s what the human organism can do. Right? This idea we cannot go from breakfast to lunch, and lunch to supper, and then from supper to breakfast, we can’t do that physiologically, this as just wrong, and so we want to at least in terms of intermittent fasting, at least from dinner to breakfast, at least 12 hours. Right?

Now, you want to go 16, whatever, there’re other ways to do intermittent fasting, but we have got to teach people that have trust in your body, eat a decent meal, and then don’t eat for five or six hours, and you’re going to be fine, and not only that, now you don’t have to think about eating, and now your adrenals aren’t stressed, and your liver isn’t stressed. You know what, I tell patients, when we’re measuring your heart rate, or excuse me when we’re measuring your blood pressure, the first number is when it’s feeding and the second number is when it’s at rest, and the second number is really the number we are really interested in. Right? Because that heart needs to rest, and you know what, your gut needs to rest, as well, it does not want to be digesting food all the time.  You don’t want to be active all the time, you need your sleep, you need to rest. Think of your gut as any other part of your system that needs rest. Right?  That means it doesn’t have to digest all the time. In fact, fasting is the healthiest a human can do to get over an illness, a chronic illness, that’s not eating at all, is putting your gut totally at rest. We just have to retrain people, and especially people who are injecting insulin, snacking, well, how are you going to, that’s going to screw up your insulin totally, so yeah, I’m a very big anti grazer, for everybody.

Dr. Weitz:                            You know, when it comes to intermittent fasting I just think it’s so ironic, because I’ve been involved with healthcare, and nutrition for 30 years, and I know when we got started the biggest thing was you have to eat breakfast, you have to eat within a certain period of time, everybody skipping breakfast, and they’re running out of the house, and that’s why they’re fat, because they eat too much at dinner, because they didn’t eat breakfast, and you have to eat breakfast, because that gets your metabolism going, so that was so important, and now the big trend is if you want to be healthy you got to skip breakfast.

Dr. Morstein:                     Well, not me-

Dr. Weitz:                          Okay.

Dr. Morstein:                     But that is for some. I eat breakfast. I’m breakfast, lunch, and supper. We have to learn, everybody

Dr. Weitz:                          A lot of people do the intermittent fasting

Dr. Morstein:                     Yeah, they do. I do fast from supper to breakfast, but I like breakfast.

Dr. Weitz:                          I’m with you on that. I prefer to skip dinner if I’m going to skip a meal. Right?

Dr. Morstein:                     I know. Here’s the deal, we have unfortunately, right now on planet earth we extremism all over the place with politics, and whatever, this, and that, and it’s certainly

Dr. Weitz:                          Planet Trump, now.

Dr. Morstein:                     Yeah. You know, it certainly entered into nutrition, too, and I think what we have to realize is that there isn’t one way that everybody is going to thrive eating, and so our jobs with Functional, Naturopathic medicine is what does this person need for their health? Me, I like breakfast, and I work better with it, but other people, especially if you have weight to lose, and so forth, doing a longer fast is great, and working out, where you don’t have food in you can burn more fat.  If it works for them, and they can do it, I mean, these are good ways to consider, but we just have to not make rules that everybody has to eat this way, and unfortunately we get too many docs that say, “I eat this way, so now everybody has to eat this way,” and that’s the exact opposite of the beauty of say Functional Medicine where we’re supposed to be looking at each individual.

Dr. Weitz:                       Right. And individualizing the program 

Dr. Morstein:                  Right.

Dr. Weitz:                       To their specific physiology, and their needs, and the way their body works.

Dr. Morstein:                  Exactly.

Dr. Weitz:                       For the final section, here, I’d like to talk about supplements that can be a benefit for patients with diabetes, or prediabetes.

Dr. Morstein:                  Yeah. Now, just to get out of the way, I have a proprietary formula called Diamend

Dr. Weitz:                       Yeah.

Dr. Morstein:                  From Priority One, which I think is a really good product. It’s in one bottle, you get everything you need at therapeutic doses, but when we’re taking supplements, yeah, I mean, people with diabetes say everybody needs to me on a good multiple vitamin, and a good one, like maybe you’re taking six a day that gets in all of the basic nutrients, so we know that you’re getting in everything you need to have your body work well, and antioxidants, and nutrients that help your organs, your liver, your adrenals work better, and help you become less insulin resistant, which is zinc, and chromium, and vanadium, and so forth, and it’s just easy to get them in one good package. 

Dr. Weitz:                       I know you mentioned therapeutic levels, and-

Dr. Morstein:                  Yeah.

Dr. Weitz:                       You talked in your book about how you can take some multi one a day vitamin-

Dr. Morstein:                  Oh, yeah.

Dr. Weitz:                       It has these ingredients that people are reading about in the latest news story, but they’re in trace levels that are going to be insignificant if you’re going to take a specific nutrient like chromium, or like cholic acid, or some of these others, it’s got to be a therapeutic level, or you’re kidding yourself.

Dr. Morstein:                  That’s an excellent point, and that’s why I think docs like us, because we can have patients bring their supplements in, we know how to read the label, see if it is a valid supplement, a good dose for what they need, or not, and like with fish oil, I’m not an advocate of krill oil. Right? Because when you see the amount of EPA and DHA 

Dr. Weitz:                       Oh, it’s a joke.

Dr. Morstein:                  It’s a joke.

Dr. Weitz:                       I know.

Dr. Morstein:                  It’s a total joke. 

Dr. Weitz:                       24 milligrams of EPA, and 30 of DHA-

Dr. Morstein:                  Exactly. People have heard that it’s krill oil, so you’re paying twice as much for a useless therapeutic EPA/DHA product, so 

Dr. Weitz:                       I know you’d have to take 20 of those capsules to get-

Dr. Morstein:                  Right.

Dr. Weitz:                       Two grams of EPA and DHA.

Dr. Morstein:                  Exactly. Thank you. Yeah. I am a big advocate of quality fish oils just like you said, and then there are supplements, you know diabetes damages oxidative damage. There’s several different pathways that happens through, but it’s oxidative damage, so we need supplements that help reduce insulin resistance, and that help protect the body, so that even if their A1C isn’t at 5.1, because an A1C over 5.5, and certainly over 6.0 is indicating by science it’s causing damage to the human body. That damage is oxidative. You’ve got some supplements like alpha lipoic acid, or NAC. they’re not just antioxidants, but they reduce insulin resistance. Right? They both help the liver, and most patients who are type two diabetic, and overweight have fatty liver. You can get some nutrients that really have a really big crossover benefit in several ways to the body. Right?

Dr. Weitz:                       By the way, in your book when you talked about lipoic acid, you mentioned something that I think most people are not aware of, which is that there’s a difference between lipoic acid, which is commonly seen on the market, and R-Alpha Lipoic acid. Can you talk about what the R four means and the difference?

Dr. Morstein:                  Right. There’s two different isomers, or chemical ways it presents Alpha Lipoic acid.

Dr. Weitz:                       We usually think of D and L forms, but-

Dr. Morstein:                  That’s with vitamin E-

Dr. Weitz:                       Oh, okay.

Dr. Morstein:                  Of course, certainly-

Dr. Weitz:                       Right.

Dr. Morstein:                  Yes, exactly D and L, and that’s with phenylalanine as well as a DL-

Dr. Weitz:                       Right.

Dr. Morstein:                  But in alpha lipoic acid there’s the R and the S isomer.  The S isomer is not active in the body.  In fact they say it may interfere a little bit with the R. Only the R isomer is active in the body, and if your bottle just says alpha lipoic acid, half of it is R, and half of it is S. About 20 years ago, companies figured out a way to make just R, and have it be stable, and so if you’ve got alpha lipoic acid, 600, only 300 of it is the R, if it says R alpha lipoic acid 600, you know, you’ve got a double effect, so we prefer just the R’s when we’re working with our patients.  Of course, Berberine, right when 

Dr. Weitz:                        By the way, what’s a therapeutic dosage for R, lipoic acid?

Dr. Morstein:                   I would say orally if you’re getting around 600 milligrams a day, there’s a very, very rare side effect I’ve only seen in two patients in 30 years, which is it can burn the stomach, but I mean for literally the hundreds, and hundreds of thousands of people that I’ve put on Alpha Lipoic acid it’s very rare. But you certainly can’t open the molecule and drink it down, it’s an acid, so it does have to be swallowed in a capsule. Little kids can’t take it until they can swallow a capsule.

Dr. Weitz:                        Okay. I’m sorry, keep going.

Dr. Morstein:                   No, I’m just saying we mentioned Berberine-

Dr. Weitz:                        Yeah.

Dr. Morstein:                   Had that great study comparing it to Metformin.

Dr. Weitz:                        Right.

Dr. Morstein:                   We like Berberine, it can upset some stomachs, but if you give a 1,000 or 1500 most people can handle that. Also, a very good liver herb as well. That’s another good product to consider.

Dr. Weitz:                         Okay.

Dr. Morstein:                    We’ve got the blueberry, bilberries for the eyes. Green tea extract was shown to help the pancreas. There’s little 

Dr. Weitz:                         You got benfotiamine which is the fat soluble form of B1

Dr. Morstein:                    Yes. Benfotiamine, very excellent, shown in studies for nerve damage, kidney damage, eye damage, and of course that, and the endothelial lining are the four areas where diabetes has its most effects, because those cells cannot prevent glucose from entering them. Insulin resistance does not affect those cells, so if your blood sugar is 300 your eyeballs are 300, and your kidney is 300, and your nerves are 300, and your endothelial lining, your blood vessels, so this is why those degenerate so commonly in people with diabetes, but benfotiamine around the max doses around 450 milligrams a day, very good safe, safe product. Ironically, we usually think fat solubles are harder to absorb than water solubles, but with benfotiamine it’s actually better absorbed than water soluble thiamine.

Dr. Weitz:                         Cool. In your book, you also talk about L-carnosine.

Dr. Morstein:                    Yeah.

Dr. Weitz:                         Which can reduce glycosylation.

Dr. Morstein:                    Yeah, I actually don’t use it too much.

Dr. Weitz:                         Okay.

Dr. Morstein:                    Yes. I learned about that from another physician years ago, and there are some studies supporting that, but to me also vitamin E might be able to do that, I just think if we’re getting the person under better control then that should lower, and it does, the glycosylation throughout their body. We think of it as the A1C, but it can also, fat and protein, it’s a fat and protein reaction, the maillard reaction, and that can happen in joints, and tendons, people with diabetes can get more into injuries of frozen shoulders when their blood sugars and A1C’s are higher, because that’s happening throughout their body, not just on their red blood cells where we can measure the A1C.

Dr. Weitz:                         How about cinnamon?

Dr. Morstein:                    Yes. Cinnamon. There’s a type of cinnamon that was shown in studies to help lower blood sugars. Some people 

Dr. Weitz:                         Which type of cinnamon is that?

Dr. Morstein:                    The Burmannii type of cinnamon. It tastes good, and it’s good in the fall when it’s getting cold. Cinnamon is another. Some patients take cinnamon, like some capsules at bedtime, and they say it can help lower their morning glucose, so it’s a pretty benign substance, it’s a 1,000 milligrams, they did studies on a 1,000, 3,000, 6,000, but even the 1,000 might be beneficial, or just using it as a spice on your food. Curcumin of course, as an anti-inflammatory, we do know that the tummy fat makes tumor necrosis factor alpha, it makes Interleukins, these can go to cells that cause insulin resistance, and so decreasing inflammation via fish oils, and curcumin can all be helpful to patients. Also, we do know the association with Alzheimer’s in people who have had poorly controlled diabetes, and curcumin has been shown to help reduce the risk of Alzheimer’s, so there was a good study in India that people eating more curcumin have less risk of developing Alzheimer’s, so again, and it’s also a good herb for the liver, so these things, again, have really good crossover for our patients.

Dr. Weitz:                            You talk about fiber and the need for fiber. What do you think about some of the resistant starch supplements on the market, and they have medical foods with resistant starches?

Dr. Morstein:                     Yeah. I mean, you know I’ve tried those and never really saw they did too much, and historically there were bars that were given to kids at night time to prevent them from having lows during the night, but kids on insulin don’t have to have lows during the night if they’re on a low carb diet. I mean it’s not like, I mean in conventional care eating whatever you want and covering it with insulin is the axium of treatment, and that’s going to cause all kind of highs and lows, but in terms of did I see real clinical benefits to resistant starch, I honestly didn’t, and if people are just eating correctly, that’s going to work for so many people. I mention it in the book as people think about it, I haven’t seen it clinically that helpful addition.

Dr. Weitz:                          You also mentioned the herb gymnema sylvestre.

Dr. Morstein:                     Yeah. I should have mentioned that earlier.

Dr. Weitz:                          Yeah.

Dr. Morstein:                     Gymnema sylvestre is my favorite botanical. There’s that and bitter melon as kind of two, but I love gymnema sylvestre, the studies have used 400 milligrams, but with some patients I’ve gone up to 2,000 or 2400. Gymnema sylvestre has been shown to help the pancreas produce insulin again, and it also reduces cravings for sugar. In a tincture form, it’s pretty amazing, that if you put a tincture of gymnema sylvestre in your mouth, and swish it around for a minute and then swallow it you can’t taste anything sweet, it’s disgusting. You can’t eat it. For some patients that are still working, you know, the holiday times, and going to parties I’ll give them a little one ounce bottle and say, “Just take this before you go to the party, then try to eat that cookie,” you’re not going to spit it out, because-

Dr. Weitz:                          Wow.

Dr. Morstein:                     It’s just going to be nothing in your mouth, and it’s really an amazing way to go, it just numbs the sweet taste for about an hour, or hour and a half.

Dr. Weitz:                            That’s great.

Dr. Morstein:                     Yeah.

Dr. Weitz:                          That’s a great hint. I know we both have patients, and we got to go, so let’s make this a wrap here. For listeners who want to get a hold of you, what’s the best way for them to contact you, and to get a hold of your book?

Dr. Morstein:                     Yeah. My book, the short name is Master Your Diabetes, it’s up on Amazon, Doctor Morstein, M-O-R-S-T-E-I-N, Master Your Diabetes, and my website is drmonamorstein, M-O-R-S-T-E-I-N, and from there I’m in Tempe, Arizona. I do telemedicine, as well. Check out my website, and give a call if you are interested.

Dr. Weitz:                          That’s great. Doctor Morstein, thank you so much for this interview.

Dr. Morstein:                     Thank you very much, Doctor Weitz …

 

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Detoxification with Dr. Bryan Walsh: Rational Wellness Podcast 77
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Dr. Bryan Walsh discusses proper detoxification with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Itunes, so more people will find The Rational Wellness Podcast. Also check out the video version on YouTube at https://www.youtube.com/user/weitzchiro/]

 

Podcast Highlights

3:04  Dr. Walsh had the typical health care provider’s view that we are all toxic and we should detoxify when we can. But then he heard a detox guru talking about phase three detoxification and it didn’t accord with his understanding of it.  Secondly, he learned that there was a phase zero detoxification. Thirdly, he had read that there was a biphasic response to toxins in that certain nutrients at a low dosage increased detoxification enzyme activity, while at a higher dosage it inhibited the same enzyme for detoxification.  This meant that the amount of some of these nutrients found in food would stimulate detoxification, while the concentrated, isolated forms and the amounts found in supplements such as in detox formulas and powders might actually be inhibiting detoxification.  This led Dr. Walsh into doing a deep dive into the scientific literature and to formulate a detox program that does not include a lot of supplements.

8:24  Which toxins each person gets exposed to has to do with your socioeconomic status, your occupation, where you live, your lifestyle, what kind of cosmetics and cleaning products you use, your water, and your air.  When you look at the data from National Health and Nutrition Examination Survey data from the CDC, we’re excreting all kinds of toxins, including heavy metals like mercury and arsenic, organophosphates, organochlorines, and aflatoxins from mold.  Some toxins exert oxidative stress and others are endocrine disruptors and may disrupt the thyroid, sex hormones or adrenal function.  Toxins may also have a direct cytotoxic effect on our cells.  Some toxins affect the endocrine system, while some have more of an effect on the neurological system and the brain.

13:52  Dr. Walsh doesn’t like most of the serum or urine tests for toxins and prefers using questionaires.  Here are two of the questionaires that he finds helpful to screen for toxic exposure:  http://www.eha-ab.ca/acfp/docs/taking-an-exposure-history.pdf  and  Qeesi.org

19:22  To properly detox you have to do three things: 1. Mobilize, 2. Optimize the detoxification pathways, and 3. Promote excretion. To mobilize, you want to go on a hypocaloric diet so that you start breaking down fat stores, which will mobilize toxins stored there. You should also use a 6-8 hour time restricted eating period, which means that you should have your two or three meals within an eight hour period of time and have no food the rest of the time. To optimize the detox pathways, this is heavily nutrient dependent, requiring certain vitamins, minerals, amino acids, and other nutrients.  You need methyl groups, you need sulfur groups, you need glutathione, you need certain amino acids, like glycine. To promote excretion, you have to sweat, so Dr. Walsh recommends using a sauna.  You want to drink a lot of water, so that you urinate.  You want to consume enough fiber so that you poop and include some binding agents to insure that the toxins leave the body.

28:18  Detoxification does occur in the liver, but also in the kidneys, the enterocytes, and even in the testes.  The four phases of detoxification include phase zero, which is the entry of these environmental pollutants into the cells. Phase one makes the fat soluble compound water soluble by adding a hydroxyl group. But it also produces a toxic intermediate, so it is important that phase two be sufficiently upregulated so that these toxic intermediates go through conjugation or sulfation or methylation or glucuronidation or glutathione or acetylation.  Then phase three takes that water soluble detox product out of the cell to be excreted through stool, urine or sweat.  You need to be careful to avoid nutritional supplements like curcumin, piperine, and milk thistle, which inhibit phase three of detoxification. For excretion, it is important to include fiber and binding agents, like bentonite clay, charcoal, and chitosan.  And it’s also crucial to sweat, such as by using a sauna, though Dr. Walsh does not like steam rooms, unless you are using purified water.  But overall, Dr. Walsh is not a believer in taking a bunch of nutritional supplements for conducting a detoxification program.  For example, when you take curcumin via food, it enhances phase III detoxification, while curcumin as supplement decreases it: https://www.ncbi.nlm.nih.gov/pubmed/18439772

43:17  Dr. Walsh also recommends as part of his 10 day detox program, 4 days of a modified Fasting Mimicking diet.  He cites the work of Dr. Valter Longo from USC who has published research on the anti-aging benefits of it, though he is not worried about the issue of a low calorie diet mobilizing toxins, which Dr. Walsh is concerned with.  So Dr. Walsh uses the same macronutrient ratio recommended by Dr. Longo, which is basically a low protein, ketogenic program, though Dr. Walsh recommends including foods that facilitate detox.  While Dr. Longo recommends the same amount of low calories to everyone, Dr. Walsh recommends low calories, but with the exact amount of calories based on your weight.

 

 



Dr. Bryan Walsh is a board-certified Naturopathic Doctor who sees patients and teaches at the University of the Western States and is an expert at detoxification. Dr. Walsch’s web site is drwalsh.com and he offers a course on detox for patients https://www.metabolicfitnesspro.com/walshdetox/  and also a course on detox for other doctors and practitioners: https://www.metabolicfitnesspro.com/everything-you-wanted-to-know-about-detoxification-2/

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.



 

Podcast Transcripts

Dr. Weitz:            This is Dr. Ben Weitz with the Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to the Rational Wellness Podcast on iTunes and YouTube and sign up for my free ebook on my website by going to drweitz.com. Let’s get started on your road to better health.

Hello, Rational Wellness podcasters. Thank you so much for joining me, again, today, Dr. Ben Weitz here. For those of you who enjoy the Rational Wellness Podcast, please go to iTunes and leave us a ratings and review. That way, more people can find out about the Rational Wellness Podcast. Today we’re here. We’re going to speak about detoxification, getting rid of toxins from our bodies. We all are probably aware of the fact that we live in an environment in which there are toxins in the air, in the food, pesticides, chemicals in products that we put on our skin, use in our house. We have tons of information that we been exposed to about all these different toxic substances that get into our bodies and, potentially, have negative health affects.

Today we have Dr. Bryan Walsh, who’s a board certified naturopathic doctor, who sees patients, teaches courses in biochemistry and physiology at the University of Western States. He’s also scientific advisor at Lifetime Fitness. He’s devoted a considerable amount of time researching and writing about the concept of detoxification to help us to get rid of some of these toxins. That’s what we’ll be discussing today, his particular approach to detox. Dr. Walsh, thank you for joining me today.

Dr. Walsh:           Thanks for having me. It’s a pleasure to be here.

Dr. Weitz:            How did you get interested in detox as a particular topic?

Dr. Walsh:           Well, that’s a great question. I’ve been steeped in the health world for a long time, well before I became a naturopathic physician. I started out as a fitness professional a long time ago, read up on nutrition as much as I could. I was a massage therapist. I was really into that world and it doesn’t take long being in that world to come across this concept that we’re all toxic and we’re going to die if we don’t detoxify. You’re introduced to all these different ways of supposedly detoxifying your body from foot baths, to colonics, to you can see people online saying, “Drink a little bit of lemon juice in the water. It’s a great way to detoxify the body,” and all these different claims.

My initial, I guess, exposure to this whole concept was that of what everybody else’s is. We’re super toxic. It’s killing us slowly and if we care about out health, we should probably detoxify. And that was it for a really long time. Then, I forget the specific time, but there was a time, recently, I’d say maybe this year or last year. I heard a particular detox guru talking about phase three detoxification. Which most people in this industry have heard of, it’s been around for a little while. I think phase three might have been discovered in the early ’90s. The way that he was describing phase three didn’t entirely jive with what my understanding was. This guy is a guru, I’m not. At least, I don’t consider myself to be. I thought, “That doesn’t really … that’s not right. I don’t think.”

I decided to go into the scientific literature and say, “What is phase three really?” I’ve heard a lot of people say a lot of things about phase three. What it is, what it’s not. I decided, I was like, “I’m not going to listen to anybody else, I’m going to do this myself.” You know how PubMed works. Where you go in and you read a paper. Then it’s cited in other papers and then you go down, the next thing you know, you have 50 tabs open in Firefox or Chrome and you’re reading all these papers. This little mini dive to just trying to figure out what phase three was three things happened.

One was I realized that this guru, who’s teaching people about phase three to sell his supplements, wasn’t entirely accurate. I have a problem with that, as we were just talking about that prior to this interview. In this space, whatever you want to call it, Functional Medicine, nutritional medicine, alternative complimentary medicine. We need to be 100% accurate with what we’re talking about, because we’re so intensely scrutinized by conventional medicine. First of all, the way he was describing phase three to practitioners wasn’t entirely correct.

The second thing that I saw was that there’s a phase zero detoxification. Which, I’ve been in this business for a long time, and I have never heard anybody ever, at any time, utter phase zero. I thought, “Wait a minute, what is this phase zero, that I’ve never heard about?” If we’re talking about detoxifying people, it should be a part of this conversation that we’re having. So, that blew my mind.

Then the third thing, and this may have been one of the things that really sealed the deal for me, was I started reading about what’s called a biphasic response when it comes to certain compounds, or nutrients, or herbs, or minerals, whatever. This biphasic response, specifically in these papers, was talking about how, at a low dose, increases certain detoxification enzyme activity, but, at a high dose, inhibits the very same enzyme for detoxification.  I thought, “Well, wait a minute.”  A low dose would be the kind that you find in food.  So if you were to eat the herb, itself, or to take turmeric, for example, for its curcumin content that, that might stimulate detoxification.  But these papers didn’t explicitly say this, but in a high dose, which I read as, isolated, concentrated, supplement form.  Trying to get as much of the herb, or nutrient, or compound in your body, as possible, might inhibit detoxification.

When those three things happened … All it was, was this guy was talking about phase three. I thought it was wrong. I decided to look it up myself. A, he was a little bit wrong about phase three. B, there was a phase zero that I never heard about. And, C, I really wondered if what we’re doing, as an industry, if we were actually detoxifying people, or not, by giving people these powders, and potions, and supplements in concentrated, isolated forms when the studies were pretty clear that many of the things that we’re using in detoxification formulas might actually be inhibiting detoxification. Then I though, “Oh my gosh, I need to completely get any bias out of my head. Everything that I though I knew about detoxification.” Wiped my brain clean. Wiped my desk clean. And I started from the very top. I said, “All right, what have I heard? That we’re toxic. All right. What does the literature really say? Are we, in fact, toxic or not?”  Two was, are these things stored inside of us? We hear that they are. Is there a synergistic effect of multiple low-dose toxin exposure all at the same time? We hear that, but what does the scientific literature say? Does the dose matter? We hear that the dose makes the poison. And, at the doses that we’re probably exposed to, that it’s not going to cause a problem, so I wanted to look into that.

 Then after answering all these, I guess, basic questions that you and I have heard about for a really long time in this industry. If those are true, if we do have exposure, if it does get stored, if it is causing damage, if there is a synergistic effect, if the dose doesn’t matter, and if a low dose can cause just as much damage as a high dose, what can we do about it? What does the scientific literature say or suggest is the most efficient and safe, I will add, safe, efficient, effective ways of actually detoxifying the body, and assessment. That was a big … How do we test this? You know the labs. There’s labs out there that are supposedly these toxin panels and will … What does the literature suggest about those, as well?  That was the dive. I ended up reading over 300 papers on this topic over the course of months.  That’s my story with this.  So I have come up, now, for air again with a brand new view of what detoxification is.  With really solid answers to those questions that I feel very confident talking about, in fact.

Dr. Weitz:            Okay, maybe we could start by just talking about what are some of the most common toxins that we get exposed to in our environment, and get stored in our bodies. What are some of the health consequences of some of these?

Dr. Walsh:           That’s actually … That’s interesting. That’s a difficult question to answer, because … Well, I just give you an example. There was one specific paper that I found that said that based on one’s socioeconomic status, we are exposed to different toxins.  For example, somebody might have a garden in their backyard, and they’re, therefore, spraying pesticides.  But somebody with a lower socioeconomic status might eat more fast food and, therefore, are more exposed to certain other toxins.  A certain class might use more, what’s it called, sunscreen on themselves, or their kids, or certain cosmetics.  They’re all common.  When you look at the NHANES data, in terms of what people are excreting. We’re excreting everything. We’re excreting everything from elements, so things like arsenic, and the heavy metals, mercury, aluminum. We are exposed to a lot of organo-phosphates and organo-chlorines that persist of organic pollutants. We’re exposed to … Some people might be exposed more to aflatoxins, because they have mold exposure, which other people don’t.

I actually think that’s a really difficult question to answer, because it depends on, well, according to studies, your socioeconomic status, the job that you have, where you live. We’re out in well-water country. I can tell you that we don’t use any pesticides in our yard garden, but I drive down the road, and these farmers around us are spraying who knows what. That’s absolutely getting into our water.

Dr. Weitz:            Absolutely.

Dr. Walsh:           But, on the other hand, and somebody that lives in an urban society and is drinking city water. They’re going to have different exposures. So it depends on your lifestyle. What kind of cosmetics and cleaning products do you use? What kind of food you eat? The water, the air, all these things. I think it’s difficult to say what are the most common ones, because that really will be specific to one’s diet, lifestyle, job, where they live, for example.

The second part of your question is the damage. That was another question I had. We hear these things are so bad. Well, why? Why do they cause problems? And it turns out that depending on the specific, I’ll call it a toxin, they’re really xenobiotics or environmental pollutants. Or the class that they’re in, they really do exert different effects. One of the most common ones, though, that across the board is oxidative stress, surprisingly. I didn’t know that, that was going to be the case, but in many individuals that have multiple chemical sensitivity, they exhibit a tremendous amount of oxidative stress. Other ones, you hear them as endocrine disruptors, but what does that really mean?

It turns out the stuff is so compelling, though, when you look at it. Depending on the environmental pollutant, let’s just talk about thyroid. Just about every single aspect of thyroid hormone physiology can be negatively impacted by an environmental pollutant. So, starting up at the top, the hypothalamus, the pituitary, TCH, thyroid’s ability to bind onto … thyroid binding globulin on the receptor, itself, and conversion on the thyroid’s production of this, every single step. We often think of the sex hormone, that these are all estrogenic. That’s not entirely true. There are some that have been shown to suppress adrenal function, and suppress cortisol, for example.

Then there’s other ones that have direct, what I call cytotoxic effects, on a cell. For example, certain ones might mess up the membrane of the mitochondria. Other ones might negatively impact some of the enzymes involved in the citric acid cycle, or the electron transport chain. Other ones have more indirect effects, like with the immune system, and then that will have system-wide effects. It’s really … There’s so many of these things out there. There’s so many classes of these and they all exert different effects. That it’s hard to say. Some of them exert more neurological symptoms, whereas other ones might impact the endocrine system more. It really depends on the environmental pollutant and what specific effects it causes. But …

Well, here’s another quick one. In the scientific literature, so many chronic conditions have been linked back to xenobiotic or environmental pollutant. Things that you don’t … I mean, of course, the neuro developmental things, like ADD, ADHD, and autism, as well as, things like Alzheimer’s and Parkinson’s. But then there’s things, like obesity, things we never think of, but the studies are really clear, cardiovascular disease, atherosclerosis, hypertension, and even diabetes. Some of these papers say the correlation is so strong that, perhaps, xenobiotic exposure is, not only associated with diabetes, but maybe a significant contributor.  Anyhow, that just speaks to the fact that it depends on what it is, but it can impact virtually any part of a cell, the mitochondria, the pliable membrane, the endoplasmic reticulum, enzymes, transporters, hormones, neurons. You name it, they can cause damage in some way.

Dr. Weitz:            What’s the best way to screen to see what kinds of toxins that we have in our body?

Dr. Walsh:           That was disappointing to me. When I looked into the literature to see what really was the … That’s the big question, of course, because … So, right now, what have we talked about?  Yes, we’re exposed. There’s absolute proof that they’re stored. They do cause damage. Then the next rational question is, all right, well, how toxic am I? When people are talking about how toxic they are, what they’re actually asking is, what’s my total toxic load or total body burden? Which is really to say, “How much do I have stored in my body?” That’s really the question. And the problem is, there’s no way to assess that. There’s no way to evaluate that. I know that people, “Well, what about the hair tissue mineral analysis test?” No. What about the urinary test to show excretion? No. I can go into some of the reasons why too.

One of the gold standards in toxicology, when evaluating this, is a fat biopsy. That’s really what we’re looking at … How much is stored in fat? Well, it turns out that for a variety of reasons, and there’s papers on this too, that suggest that you have different amounts of stored xenobiotics in subcutaneous fat, than you do visceral fat, than you do in different fat depots in different areas of the body. And these papers say that, that doesn’t correlate to serum levels, so you can’t do a blood test and say that, that reflects you and what your storage is, because it may differ.  Then there was one, and this is a rodent study, so you have to take that into consideration. Well, here’s a good example. Let’s say you and I, right now, let’s say we practice in the same area. We live the exact same lifestyle, exact same exposure. You’re following a hypocaloric diet, right now. Intermittent fasting, time restricted feeding, hypocaloric diet. I’m stuffing my face, standard American diet. I’m eating more than my basal metabolic rate. We both go to do a test. Now, because you’re in a hypocaloric state, you’re probably mobilizing more of your stored xenobiotics, and every mammal study says that. That when there’s a hypocaloric, or fasted, state, serum levels of xenobiotics go up every single time, every single mammal, including humans.

Now, I’m in an anabolic state. I’m storing things. When we go to do this toxic panel, you come out sky-high in all these toxins. And you see your practitioner and they’re like, “Oh my gosh, you are so toxic. You must do a detoxification program.” Then, me, because I’m in an anabolic stuffed fed, overfed state. That mine are probably stored. And my levels, on my test, might come back as normal or low. And the practitioner says, “Wow, you’re not toxic, at all.” When, in fact, I might be far more toxic, in terms of my storage, than you are, but you’re in a hypocaloric state. Right there, that totally negates … It’s a severe confounding variable when considering assessments.

Then the last one, that rodent study I was going to say, they showed that when these … They put these rats on a yo-yo diet, poor rats. They would go hypocaloric and their xenobiotic levels would go up in their blood. Then they’d make these rats hypercaloric and guess what happened? These xenobiotics went into different tissues. You might have a certain amount in a certain fat depot in your body that does get mobilized, but then it’s going to go somewhere else depending on your caloric state. In terms of screening, all of this is my opinion. It’s based on the scientific literature, but people can use it how they want. Is there is some pretty good questionnaires that are out there, that are in the … They’re validated questionnaires in the scientific literature that, I personally, think are amongst the best ways of screening if we have toxic exposure or not.

Dr. Weitz:            Can you mention which ones those are?

Dr. Walsh:           There’s a whole bunch of them. One of them is abbreviated and I forget the actual … It’s the Qeesi questionaire. If you do links to this in your show notes, we can-

Dr. Weitz:            Yeah, I will. Yeah, maybe you can email me.

Dr. Walsh:           That one’s the most elegant. It’s fairly long. I’ll give you a couple of them that I like for two reasons. One is this one is very comprehensive. It’s not quick, 10 questions, are you toxic or not. It looks at a variety of things from your actual physical exposures and your lifestyle, as well as symptoms across a variety of systems in the body. And I think is really very comprehensive. The benefit of some of these, though, is it forces you, when you ask these, or answer, these questions to jog your memory to see what your exposures might be that you are totally unaware of. Right now, you can say, “What are my exposures? I drink reverse osmosis filter water. I eat organic food. I use coconut oil for my lotion. Apple cider vinegar for my deodorant. I don’t have any exposures.”  But when you go through some of these questionnaires that have these questions, you say, “Oh my gosh, I work in a building that whatever.” They’re really good at helping, not only see if you might have a certain amount of toxicity, if you will, but also what the sources might be.

Dr. Weitz:            Okay. In your concept of detoxification … Actually, you were talking about the phases of detoxification. I’m not sure everybody even knows what phase one and phase two are, and you were talking about phase zero and phase three. Well, actually, your concept of detoxification, you have three basic principles, and then you list the phases in a second one. Maybe we could go through your three main important principles of detoxification that you outline in your program.

Dr. Walsh:           Yeah. And, again, I humbly will say that I think my … I’m a teacher, not by choice, I think I was born into it. When I look past throughout my entire life, everything has been teaching. I say that because when I go through what these three principles are, there’s a feeling you know that being empowered just feels amazing. That you feel like that you know enough information that nobody can pull the wool over your eyes. That you’re an informed individual. So by teaching these three things, these are just … These are principles that must be in place for anything to call itself a detoxification program. I say this so that when people are evaluating, “Well, what about this detoxification?” They can run it past this list of three things.  The first thing that for something to call itself a detoxification, that it absolutely must include is mobilization. You have to get these things out of storage.

Dr. Weitz:            I thought you were going to say it has to come in a box, just kidding.

Dr. Walsh:           No. It can, if it’s a well developed one, it absolutely can, UPS, no.

Dr. Weitz:            Okay.

Dr. Walsh:           You have to mobilize in the first place. The best ways to mobilize, that I’ve seen, and also makes physiological sense, is to go on a hypocaloric diet. Now, i think a calorie restricted diet, I also believe a time-restricted feeding in a window of about six to eight hours, is probably the best. And all that calorie restriction means is less than, essentially, your basal metabolic rate. Exercise. So the technical word is, lipolysis, which is the breakdown of the lipids, or fat cells, but that’s where the majority of these things are stored. When you are in a state, a catabolic state of lipolysis, you do get mobilization of toxics, period. This is not conjecture.

Dr. Weitz:            Right.

Dr. Walsh:           Every mammal study that I’ve looked at, including humans, when people, or mice, or monkeys go hypocaloric, their levels in the blood go up every single time.

Dr. Weitz:            You’ll have to admit that virtually every detox program out there involves some sort of modified fast or fast. They pretty much all involve eating less foods.

Dr. Walsh:           Right.

Dr. Weitz:            So this concept, I think, is incorporated in most of the commercial detoxification-

Dr. Walsh:           Whether they knew it, or not, right. It absolutely involves that.

Dr. Weitz:            Right.

Dr. Walsh:           The second thing, then is, and this speaks to those phases of detoxification. You have to optimize detoxification. Step one is to get them out swimming in your body. All these things, now, are mobilized. They’re going through your blood. You are not going to get rid of them. These are the fat soluble ones that you do not, you cannot … The normal routes of excretion are any water forms of excretion. You can sweat it out. You can urinate it out. There’s a little bit of water in stool, so you can poop it out. You can, technically, salivate it out, or if you cry a lot, you watch a lot of This is Us reruns, then you can cry it out, technically, through tears.

Those are all … I mean, in theory, you could measure any one of those as a form of toxin … Those are all measurable things. We have to take these things that are fat, they like fat, and turn them into things that like water, so we can get rid of them. Those are those four phases of detoxification; phase zero, phase one, phase two, phase three. You have to optimize those. If you’re not, then these things just go in the body and you can’t excrete them, because they’re still fat soluble. Then the third, and last one is, you have to focus on excretion. I’ll just take a step back and say, “Let’s talk about different detox programs to see if they fit those things.”

Mobilization, improved detoxification pathways, and then to really, really facilitate excretion in some ways. Let’s say that somebody were to do a juice fast, some popular juice fast where the juice comes in a box, or maybe they’re just juicing things on their own. Are they in a hypocaloric state? Probably, if all they’re doing is just drinking juices, they’re probably in a hypocaloric state. So they’re probably mobilizing, and that’s fine. Step two is, are they improving detoxification pathways? Now, it depends on what they’re consuming. There are studies that suggest that things commonly juiced, things like carrots and celery-

Dr. Weitz:            We’ve had a technical difficulty, so we’re going to continue this podcast. We’re not exactly sure where we left off, but hopefully we won’t have any lost train of thought. So, go ahead Dr. Walsh tell us more about detox.

Dr. Walsh:           Yeah, no problem. You can tell me if I’m going too far backwards. I was saying the three things that are required in order for somebody to do a detoxification program; mobilization, optimizing detoxification, and then optimizing excretion. Those three things are critical. Then what I said was if you go back, and you start evaluating things that are supposed to be detoxification programs, where they detoxify the body, they have to have those three things. So, just a juice fast, is really common. You mentioned that most juice fasts are hypocaloric, so they probably are increasing mobilization. But then, I think this is the part that we got a little bit glitchy, is depending on what somebody’s consuming, you may, or may not, be either stimulating or inhibiting detoxification pathways. The things that have been shown in the literature to stimulate detoxification pathways, people typically aren’t juicing things like, broccoli, for example, or cabbage, or possibly things like mung beans, which aren’t really juiceable.

Dr. Weitz:            But it is the case that detox is a nutrient dependent process, right?

Dr. Walsh:           Absolutely. Well, yes. I mean, if you want to really get into the biochemistry of it, there are a number of different micro-nutrients, vitamins, and minerals that are even required for these pathways to be taken place in the first place.

Dr. Weitz:            Right.

Dr. Walsh:           In phase two, which I’ll get to, but just really quickly. You need methyl groups, you need sulfur groups, you need glutathione, for example, you need certain amino acids, like glycine. It’s heavily nutrient dependent.

Dr. Weitz:            Hence, the concept of trying to put together a program that has concentrations of these nutrients has some basis in the science, right?

Dr. Walsh:           Totally. Here’s the point. Is a juice fast a detoxification program? From the mobilization standpoint, yes, it probably is. You will be mobilizing. But from optimizing detoxification, I think that, that’s highly skeptical. And it depends on what somebody’s juicing. There’s some evidence in the literature that things that people usually juice, like apples, carrots, and celery may actually inhibit certain detoxification pathways, so then, that’s questionable. Then for excretion, if somebody is just doing a juice fast, they are not doing anything to enhance excretion. In fact, if they’re only consuming juice and, therefore, not fiber, and we can go into great detail on this, or not, but they’re probably urinating, and that’s fine. If they’re not sweating, that’s a huge problem. It’s a huge problem when it comes to detoxification.  Certain things are preferentially excreted via sweat, other ones are preferentially excreted via biliary, in the bile and the gastrointestinal tract. If you’re not sweating, or your not binding things up severely in your gastrointestinal tract, and in the juice fast, you’re not, then you’re not excreting. I, myself, would say that a juice fast is not a detoxification program. Yes, it mobilizes whether, or not, it increases detoxification pathways depends on what you’re consuming. Then the third one, excretion, I’d say a big, no, to that.

Does a colonic, is that a detoxification? Well, if you’re not mobilizing, then, no, all you’re doing is your moving things through your bowels faster. Which is great, that’s excretion, that does nothing for the second step detoxification of the first step, mobilization. That’s what I really want people to do is to be able to look at a detox … something that is allegedly a detoxification program, and say, “Does this increase mobilization?” Check, yes. “Does this increase detoxification pathways?” That’s a big one. That’s questionable with a lot these nutrients that people are using in powders, and supplements, and capsules. And excretion, is just saunaing detoxification? You maybe excreting things that you had swimming around in your interstitial fluid, technically, but not out of your cells, because you might not be in that mobilized state.

Dr. Walsh:           So those three things are critical for something to be called, to truly, truly be called a detoxification.

Dr. Weitz:            Can we go through those detox pathways? People typically talk about phase one and phase two of detoxification. It’s phase zero and phase three that are the newer ones. Typically, people talk about phase one and phase two as related to the liver, correct?

Dr. Walsh:           Yeah, well, and that’s not true, at all. When people talk about these … I’ll tell you what the phases are, then we’ll talk about why it’s not just a liver. The liver happens to be a huge organ and, yes, it does this, but the kidneys do this very well. The enterocytes of the intestines do this very well. In men, it turns out the testes, actually, do this very well also. Which isn’t surprising, given the role of the testes in terms of, essentially, passing along somebody’s DNA in that xenobiotics. If one couldn’t detoxify well down there, then that could really disrupt somebody’s …

Very simply, if you’re to picture, like a box. I’m trying to look for a prop real quick, but I don’t have one. If a box is a cell or, you’re in a room there. I would say, if somebody’s in a room it’s pretty easy to picture. If this room has two separate doors, this is as simple as it is. Phase zero is quite simply the entry door into your room, which is the cell. Your cell has a nucleus and mitochondria. It has a computer. It has lights and electricity and ATP. That first door is phase zero. That’s the entry of one of these environmental pollutants inside of a cell. You can say a liver cell, but it’s not the only organ that does this. It comes in, now, it’s inside the liver cell. We’ll say it’s a person came through that door.

Then phase one is biochemically not too challenging, but I’ll say what it does biochemically and then I’ll change it back to this metaphor or analogy. Phase one makes that fat soluble compound, first of all, makes it water soluble. It does so, not exclusively, but either by adding what’s called a hydroxyl group or exposing one that was already there. Now, this has this hydroxyl group on it. It’s water soluble. The way that I use this as an analogy. If somebody walked through the door, phase zero. They’re now inside the cell and you, put a sticky note on their forehead, just right on their forehead, or you start berating them, “You suck as a human being. You’re a horrible, miserable, ugly, smelly human being.”

Now, and that’s phase one. Now, this person is really angry. Who wouldn’t be if you start to berate … and they have a sticky note?  So they start trashing your room. They throw your computer across the desk. They start knocking lights over. They start doing all these things.

Dr. Weitz:            Fake news.

Dr. Walsh:           But in a cell, after phase one, and this isn’t across the board, all the time, but it’s actually considered to be more damaging to the body than, in some cases, the original environmental pollutant was, after phase one. You just berated this person, “You’re fat, ugly and your breath stinks.” Now, they’re really, really mad, but that’s phase one. But phase two is collectively called conjugation, and conjugation means, to add something.  Now, in phase two, you’re like, “I’m so sorry. Here’s $100 bill.” Well, the person may have had hurt feelings about what you said, but now you gave them $100 and they’re not angry anymore. After phase two, it’s still water soluble, but it just got $100 bill. It’s not going to damage anything inside of your cell anymore. It’s not going to damage your room. Now it’s a happy person. You made fun of it, it was angry, it started messing things up after phase one. Phase two, you handed it something, now, he’s happy.

Dr. Walsh:           Now-

Dr. Weitz:            Now, let me just stop you for one second. So the story that’s often told about detox, especially from some of the companies that provide these detox programs is, phase one produces a toxic intermediate that’s why if you just do a juice fast you get all these toxic reactions, and headaches, and all these negative things. You have to have the right nutrients that help support phase two, so you take that toxic intermediate, put it into a water soluble form so it can get excreted. Therefore, you support phase one and phase two, and that’s the end of the story.

Dr. Walsh:           Yeah. That’s a good story, but if the intermediate metabolite, after phase one. With that hydroxyl group, it’s technically a free radical. Now, I haven’t seen too many people that get sick from free radicals, if that makes sense?

Dr. Weitz:            But doesn’t that explain when somebody does a juice fast and they have toxic reactions-

Dr. Walsh:           I think that part of it-

Dr. Weitz:            – and the amino acids and the other nutrients for phase two.

Dr. Walsh:           I don’t know. I’m not convinced that, that … It might be because of mobilization, and they’re not excreting things. I don’t know if it’s only because it goes through phase one. Technically, I mean, they’re water soluble, but technically it’s still inside the cell. It hasn’t gone out of the cell yet, so that’s a good story, and it might be true, but I don’t think there’s any proof as to that’s what’s causing this.

Phase two is the conjugation. You hand them $100 bill, or in the case of actual biochemical pathways, sulfation hands to the sulfur group, methylation hands to the methyl group, glucuronidation hands to the glucuronic acid, glutathione gets glutathione glycine, acetylation gets in the acetyl group. That’s the $100 bill. Now, it’s water soluble and happy. Now, it has to get out of the cell to go back into the interstitial fluid, which is water, to be excreted. That’s the other door and that’s phase three. Now, here’s the problem. There’s certain things that can block phase zero, like diesel exhaust has been shown to block food. It’s fairly new. It’s only been discovered in the early 2000s. But phase three, curcumin blocks phase three, piperine from black pepper, which is usually used with curcumin to make it more available, blocks phase three. Milk thistle, honestly, is a mild phase three inhibitor, as well.

And here’s the thing, so now you have this happy person that could leave that third door. Then you’re done with them. You’ll never see them again, because they get excreted. But here’s the problem, you know, beta glucuronidase, which undoes glucuronidation. There are other enzymes that can undo conjugation, which to put it back into the metaphor is, there are things that can take that $100 bill away from that person, whether it was sulfation or methylation. Can take that $100 bill and, now, they’re the intermediate metabolite again. If you block phase three, and that person, metabolite, after phase two stick around inside that cell, now, the conjugation reaction can be undone. Now, it’s back in the intermediate metabolite. That’s why making sure that … This becomes my opinion, at some point here, but I don’t know that we should be taking a lot of supplements when it comes to a detoxification program. Because the reality is, and I can go head-to-head with a lot of people on some of these things, it’s really hard to say whether something actually improves detoxification or not.

Not from enzyme activity, or MRNA expression, for these proteins. There are all these things, but if it actually … What I’ve looked at, which is biphasic response, is that food, and the doses that are found in food, will generally stimulate detox … There was one great paper, by the way, that looked at food-based curcumin and isolated curcumin. Food based stimulated detoxification pathways and isolated absolutely inhibited. In fact, conventional medicine … Think about cancer, think about chemotherapy. What they really want is to keep that chemotherapeutic agent inside of the cell, so that it can fight cancer, correct?

Based on what we’re saying is that best way to do that is to block phase three. If you close that second door, you keep inside that cell whatever is inside that cell. If it’s a chemotherapeutic agent, that’s what you want to be able to exert more of an effect on cancer. What is conventional medicine using as a potential phase three inhibitor to help augment, or improve, chemotherapy? Is curcumin, so should curcumin be in a detoxification program? If it’s truly detox, you want to open up phase zero, have phase one and phase two working very well, and keep that second set of doors wide open, phase three, so that stuff can actually get out. Then, for the third part of the detox, is to be excreted via sweat, via bile and poop, via urine, or, like I said, technically, salivate, saliva, or tears.  I don’t know if that answers the question. But that’s phase zero. Phase zero is entry into the cell. Phase one redox, oxidation, the hydroxyl group is added or exposed, intermediate metabolites, sometimes more toxic, not always. Phase two conjugation gets handed something. Phase three exits the cell and then is excreted, as long as the body is excreting.

Dr. Weitz:            Interesting.  In order to promote excretion, you talk about using particular fibers and binding agents to help get rid of some of these toxins?

Dr. Walsh:           Yeah. What I did, again … Bentonite clay, I’ve been familiar with bentonite clay, as a fitness professional, and different types of fibers, and all these things. But what I wanted to do was look to the literature and say, “Well, what actually shows an improvement in the excretion and, not necessarily, of xenobiotics, but of bile.” So like a bio-acid sequester, like cholestryramine, the old cholesterol lowering drug, bound up bile to excrete it. If we can bind up bile, because so many xenobiotics are found in bile, and is their primary form of excretion, we need to bind up bile. We need to bind up all the stuff in the gastrointestinal tract for a variety of reasons, but I tried to find things that had some scientific basis behind it, so things like charcoal, for example, fiber, soluble, insoluble fiber.  An interesting one is chitosan or ketosan, which is typically used for fat loss, not very well. But there is papers showing that it is, actually, effective at increasing xenobiotic excretion via bowel habits. The other big one is sweat. You have to sweat. In fact, I recently came across a paper that, the short version was and, again, if I come back in a future life as a lab rat doesn’t sound very good. They had two groups of mice or rats and they gave one group a pretty significant burn on their skin, which is unfortunate. They injected both sets of mice with a certain xenobiotic and, not surprisingly, the ones that had a burn had higher levels of this environmental pollutant, because skin is such a major route of excretion. And, in fact, is the preferred route of excretion of some xenobiotics, not all, but some.

So if somebody is not actively sweating, during this hypocaloric phase, then I don’t think we’re getting rid of as much as we need to. To the point then, this is a bold statement. But I have some more papers that I’ll be adding as some bonus content coming down the pike. This stuff just blows your mind, blows your mind. I would not, myself, my family, or any patients, or clients put them on a fat loss program without supporting detoxification pathways, period. If they couldn’t sweat, I would say, “You probably don’t want to do a detoxification program.” If it’s really … I’ll just give you a tip on some of these things. There’s evidence that weight loss actually increases one’s risk for dementia, cardiovascular disease, diabetes and cancer, very strong, and the author cite this as a reason. Weight loss induces mobilization of xenobiotics. They go up and if you’re not getting rid of them, cause damage to cells way down the level.

Now, you look good in sexy jeans, or skinny jeans, but in 20 years might have cancer, or dementia, because of the weight loss. And, in fact, a steady increasing BMI, as one ages, seems to be protective over some of these thing, which is counter to what we want to look like, ourselves, but it’s very compelling stuff. Yeah, this is real, man. I would not do a fat loss program without making sure I was sweating and excreting and supporting detox. I would not. I would not put a patient on one, because I think that the detriments are too strong.

Dr. Weitz:            Sounds good. I know you’re a fan of infrared saunas, or a particular type of infrared sauna, right?

Dr. Walsh:           Well, you know, no, actually. I don’t like steam rooms, because of the water that they’re potentially using. I think that you can have a lot of model organic compounds found in steam. Again, unless it was purified water. But, no, here’s the thing. Again, I try not to have much of an opinion, but base it off of what I’ve read in the literature. Interestingly, in the literature, when they collect the sweat they’ll have a cohort of people to collect their sweat to look at xenobiotic levels. But they don’t tell them how to sweat. So, whether it’s via exercise or in a sauna, it didn’t matter. That when you sweat, you excrete. There’s people out there that might split hairs about a far infrared sauna and a near infrared sauna or the old ones, which are called the radiate heat saunas.  Listen, from what I’ve read, I tend not to like to split hairs over things, just sweat, man. If all you have is an old coal one, and you pour your water on it, and that’s all you have. That’s fantastic, do it. I love near infrared, personally. I think far infrared are interesting. There’s some questions about the electromagnetic frequencies, and stuff, and some of those things. But the goal is to sweat. I don’t care how somebody … In fact, I have people contacting me about my program. They’ll say, “I don’t have access to a sauna, but what if I went up into my attic?” I’m like, “As long as it’s not filled with asbestos or all this toxic stuff up there, then fine. Listen, sweat. It doesn’t matter.”  I like how the near infrared saunas feel and the bright red lights. But, no, I think to say one’s superior is myopic, personally. I think just sweating, according to science, is the most important aspect.

Dr. Weitz:            Interesting. I got that from an interview you did with Mercola. Maybe it was Mercola who liked the near infrared.

Dr. Walsh:           Yeah, he likes near infrared more than far.

Dr. Weitz:            Okay.

Dr. Walsh:           But that’s splitting hairs. To me-

Dr. Weitz:            He didn’t like the EMF thing about it.

Dr. Walsh:           No, just to sweat is the most important aspect.

Dr. Weitz:            Let’s go-

Dr. Walsh:           I would say this … Sorry to interrupt. What’s nice about the sauna, though, is it’s controlled. You can control the temperature and the time, so that, in terms of knowing the quantity that you’re sweating. That’s why I suggest the sauna, but if someone doesn’t have access to it, just sweating is what’s important.

Dr. Weitz:            Let’s go over one more thing. This will be the final question. Is part of your program involves … I know you have a 10-day detox program and part of it includes a four-day version of the Fasting Mimicking Diet that’s been popularized by Dr. Valter Longo, who sells you this box, or his company, and people who are part of this program called, ProLon, sell you this box of pre-packaged foods that you open up and make soup and things like that. You basically have put together a program that involves using real food, but to create the same effects.

Dr. Walsh:           Yeah. The short version is, if someone’s never done a detoxification, just an average person, that maybe has never done one. I recommend doing what I put together, just my view on this, is a 10-day program. The first six days, because of what you talked about, is the very high nutrient … It’s low calorie. It’s hypocaloric, you have to mobilize, but it’s fairly high protein. It’s high protein to ensure that, whoever this average person is, that maybe wasn’t eating perfectly, isn’t particularly healthy, might be protein deficient, or I should say, amino acid deficient. That they have the sulfur groups, and they have the methyl groups, and they have the glycine and all the precursors, the glutathione, in order to really support those phase two detoxification pathways.

That’s why I recommend the 10-day program for somebody who hasn’t done it before. That’s the first six days. Then the last four days, or someone could do five, if they wanted. It is what I refer to as a modified fasting mimicking diet.  Now, I think the work that Longo did is … the papers are brilliant. I think they’re fantastic. The findings of these things are so interesting.  My concern, however, is that every paper that I’ve looked at, where any mammal goes hypocaloric, their xenobiotic levels go up, period. He’s looking at this from diabetes reversal, and autophagy, and mitophagy, and all these health promoting effects, and that’s great.  However, instead of … So the macro-nutrient ratios that he’s come up with are brilliant. The calorie levels, which I won’t get into, but I think that should be based on one’s weight, rather than just having set calorie levels.  So a very hypocaloric diet with very specific macro-nutrient ratios.

Dr. Weitz:            By the way, what are those macro-nutrient ratios?

Dr. Walsh:           It depends if it’s … According to the one paper that I use, that have the specific ratios. Honestly, it’s basically ketogenic.  It’s very low calorie, first of all, but it’s moderate carbohydrates, very, very low protein.  In fact, you can, in what I put together, you can reach your protein levels just by eating vegetables for that are required.  It’s very low protein, which there’s no additional protein that’s actually consumed.  The amount of protein found in the vegetables that I consume, you hit your mark.  Then a little bit of fat.  It’s like carbs, protein, and fat, so that somebody can be in a ketogenic state and not push themselves out. My concern with his work, however, is while really compelling stuff that he’s produced is what about this xenobiotic thing? What about these papers that I’ve seen that show that, if you lose weight, or if you mobilize, and that can cause some other chronic conditions or situations much later in life? Instead of just saying, “Here’s some soup or here’s some avocados and some tofu, or whatever it is to reach the macro-nutrient ratio level that he recommends.” I recommend specific food that, according to the literature, have been shown to support detoxification pathways.

I mean, again, what he’s put together is brilliant. I think it’s genius. I think it’s fantastic. I have no problems with it, other than, if you just eat rice and avocados to meet those macro-nutrient ratios, you’re basically doing nothing to help support detoxification pathways. And these people will have increased environmental pollute levels in their blood, period. I say, instead of eating foods to meet the macro-nutrient ratios, eat specific foods that, according to the literature, have been shown to support detoxification impact. That’s the 10-day.

Now, what I do recommend for someone, like yourself, however, if you’d really wanted to do a good detoxification program over the course of a few months, is not to do … You’re a healthy guy. You eat a healthy diet. You live a lifestyle. I think that you could do two four to five day fasting mimicking diets a month. In week one, you might do four or five of those days. Then, again, in week three do another four or five days. And the next month, do the same thing. So you don’t need to do the full 10 days, because arguably those last four or five days, where it’s really hypocaloric, that’s where you’re going to get the maximum, and it’s time restricted eating, you’re going to get the maximum mobilization. And if you’re eating the right foods … I have some evidence that this absolutely lowers xenobiotic levels.  For someone, like you, that’s already healthy, I don’t think you need to do the 10 days. I think four to five day, modified fasting mimicking diet, a couple times a month would be the most effective way.

Dr. Weitz:            Awesome. It’s been a great interview Dr. Walsh. How can we find out about your fasting programs and the other programs you offer?

Dr. Walsh:           Remember, I don’t agree just with fasting. I think we’re too sick to-

Dr. Weitz:            I’m sorry. I’m meant your detox programs.

Dr. Walsh:           I know.

Dr. Weitz:            How can listeners and viewers-

Dr. Walsh:           Yeah. If you go to drwalsh.com, D-R-W-A-L-S-H dot com, backslash detox, that’s all you have to do. Then there’s a funny little picture of me with two buttons. One says, “Practitioner,” and one, basically, says, “Non-practitioners,” because I created two programs. The practitioner version of this goes into great detail. They both go into the science. I show the studies on the screen. I walk people through the pathways on the whiteboard. Again, I don’t want to tell people what to do without having the reason why the recommendations are there. So that they’re knowledgeable and empowered and understand why they’re doing these things. Why everything is in the program that’s in there. I don’t just say, “Take these potions and detox.” I want them to know. The difference in the programs is the practitioner program is about nine hours. The non-practitioner is about four hours of video. The practitioner program goes in way more detail in the biochemical pathways of phase zero, phase one, phase two, phase three. I go heavier into the science. It’s more technically detailed, but they both have the same output, where it’s, here’s the program, here’s how to do it.

Dr. Walsh:           When I add on some of these additional, bonus, content features, both programs … And the practitioner program, if a practitioner gets the practitioner program, they also get the non-practitioner program for free.

Dr. Weitz:            Great. Any other points of contact you want to give out for people who would like to get hold of you?

Dr. Walsh:           No, that website is the hub.

Dr. Weitz:            Good. Good. Excellent. Well, thank you, Dr. Walsh.

Dr. Walsh:           It was my pleasure. Thanks so much.

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
How to Fix Your Fatigue with Dr. Evan Hirsch: Rational Wellness Podcast 076
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Dr. Evan Hirsch discusses how to fix your fatigue with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Itunes, so more people will find The Rational Wellness Podcast]

 

Podcast Highlights

2:51  What distinguishes fatigue from chronic fatigue is that fatigue is generally relieved by a good night of sleep and chronic fatigue goes no for an extended period of time, usually longer than 6 months. Dr. Hirsch has found 15 different causes of fatigue: 1. not drinking enough water, 2. not getting enough good sleep, 3. deficiency in adrenals, 4. deficiency in thyroid, 5. deficiencies in sex hormones, 6. nutrient deficiencies like B12, vitamin D, magnesium, 7. heavy metals, 8. chemicals, 9. molds, 10. infections, 11. allergies, 12. negative emotions, 13. EMFs, 14. hidden dental infections, 15. parasites.  One of the founders of Functional Medicine, Dr. David Jones once said that the key to health is finding what we don’t have enough of and providing it and finding what we have too much of getting rid of that.

8:45  Adrenal fatigue or dysfunction can be a common cause of fatigue.  While testing for adrenals can be helpful, you can tell from symptoms if there are adrenal problems. Dr. Hirsch likes to start by using Adrenal Px from Restorative Formulations, which he’ll have patients take every 3 hours until 4 pm and if they need to he will recommend up to 3 capsules per dose.  In addition, make sure they are sleeping well, eating healthy, drinking water, etc. Dr. Hirsch mentioned that one doctor analysed all the studies on cortisol levels and fatigue and there was no correlation at all. If his patients need more support, he’ll recommend Adrenal Px syrup and he may add in some licorice root.  If that hasn’t taken care of the problem, he’ll use a product called Adrenal Para-NS from Byron White formulas. And finally, that hasn’t helped enough, then he will recommend hydrocortisone. 

16:40  Thyroid is another important gland that affects energy levels. Low thyroid is really two conditions: 1. low thyroid prodicution by the thyroid gland and 2. an autoimmune condition in which the immune system is attacking the thyroid. And this is usually because of either heavy metals, chemicals, molds, infections, allergies, emotions, or EMFs. One infection that Dr. Hirsch sometimes finds is involved is Bartonella and getting rid of Bartonella with the Byron White formulas can sometimes completely reverse low thyroid.  To support the thyroid Dr. Hirsch may start with some thyroid glandulars or iodine or kelp, but he generally finds that prescription thyroid is the most effective.  He does not like using Armour or Nature-throid because some patients may bneed more T4 and some may need T3 and we have to figure out the right dose for that individual. You also need to support the thyroid by supporting the adrenals and there’s this beautiful dance between thyroid, adrenals, and the sex hormones.                                               

19:45  Gluten, dairy, soy, and genetically modified corn can all play a role in the causation of thyroid autoimmunity.

24:04  Dr. Hirsch will sometimes use 20,000 IU vitamin D if a patient’s levels are below optimal, since vitamin D will stimulate T regulatory cells, which can help autoimmunity.  Most of his clients take 10,000 IU for maintenance.

27:42  Balancing sex hormones can help with fatigue. He finds that a lot of times when he finds younger men with mold, which results in low testosterone levels and low libido and once we get rid of the mold, their testosterone and libido comes back.  He will test for mold with urine testing from Great Plains or Real Time Labs after taking 500 mg of liposomal glutathione twice per day for seven days. For heavy metals he will use the Doctor’s Data provoked urine test using DMSA and test before provocation for baseline and then test after DMSA provocation.  To screen for other chemicals besides heavy metals he will use the Great Plains Lab GPL-TOX urine test also with glutathione provocation. To get rid of metals and other toxins he will recommend saunas, coffee enemas and cilantro and chlorella and modified citrus pectin. Dr. Hirsch likes to use a combination of products by Byron White that open up the liver and kidney pathways and helps to open the lymph and the neurolymph. He finds that most of his patients require at least 6 months to a year of treatment and sometimes as long as 36 months.

39:45  To support mitochondria, which are the organelles in the cells that produce energy, and they produce 70-80% of our energy.  Our mitochondria can get damaged by heavy metals, chemicals, molds, infections, allergies, emotions, and EMFs.  Not only do we have to remove that crap off of the mitochondria but we also have to inject the mitochondria with some good love in the form of like Acetyl-L-carnitine, L-carnitine and D-Ribose, CoQ10.  Dr. Hirsch likes to recommend a product from Research Nutritionals called ATP Fuel for supporting the mitochondria and he sees a boost in energy from using it.  Dr. Hirsch is on a mission to help a million people resolve their chronic fatigue!

        

 



Dr. Evan Hirsch is an MD who is practicing Functional Medicine with a focus on treating patients with chronic fatigue.  His website Fix Your Fatigue  offers a free download of his best selling book, Fix Your Fatigue.

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.



 

Podcast Transcripts

 

Dr. Weitz:            This is Dr. Ben Weitz with the Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to the Rational Wellness Podcast on iTunes and YouTube, and sign up for my free e-book on my website by going to drweitz.com. Let’s get started on your road to better health.  Hey Rational Wellness Podcasters. Thank you so much for joining me again today, Dr. Ben Weitz here. For those of you who are enjoying the Rational Wellness Podcast, please go to iTunes and give us a ratings and review, that way more people will find out about the Rational Wellness Podcast. Our topic for today is fatigue and what do we do about fatigue. Today we have Dr. Evan Hirsch, who’s a medical doctor who practices in Olympia, Washington, using a Functional Medicine approach and his practice is really focused on treating patients with various forms of chronic fatigue. He’s written a best-selling book, Fix Your Fatigue. Dr. Hirsch, thank you so much for joining us today.

Dr. Hirsch:           Thank you so much for having me on Dr. Ben.

Dr. Weitz:            So since you’re a conventionally trained MD, how did you veer off the path into functional medicine?

Dr. Hirsch:           So, when I grew up, my mom was really into natural stuff. So, I think I was about 10 when she first started down her path, and she had very high cholesterol genetically, and she was able to reverse it using oat bran. We went on this six months of oat bran muffins, oat bran this, oat bran that. I remember just being really disgusted by oat bran at the end of it, but she brought her cholesterol down significantly and I thought that was very interesting, and then when I went through medical school, I just am very curious, I ask a lot of questions, and I wasn’t happy with the answers that I was getting from all of my professors and doctors-

Dr. Weitz:            Just put people on statins, right?

Dr. Hirsch:           Exactly, and so I was saying, “Well what’s the cause of the cholesterol issue? What’s the cause of the high blood pressure?” And getting to the root, and I didn’t like the answers I was getting so I went off into holistic medicine. I got board-certified in holistic medicine, went into integrative medicine, functional medicine, environmental medicine and that kind of led me down that path and then my wife got chronic fatigue and then a couple of years later I got chronic fatigue, and so it was working through all that that I really became so in tune with what the causes were for fatigue and how to resolve them.

Dr. Weitz:            Great, so what are some of the most common causes of chronic fatigue? And by the way, what distinguishes chronic fatigue from other forms of fatigue?

Dr. Hirsch:           It’s a great question. So fatigue in general just means that you’re tired and it’s not resolved with rest, because theoretically you should be able to work out hard and then you sleep well and then the next day if you’re not well rested you sleep well the next night and then you’re fine, so it may take a couple days to recover depending on whether you ran a marathon or not but you should recover. Fatigue is when you don’t recover and then chronic fatigue is when it’s been going on for a extended period of time. Conventionally it’s usually longer than six months or so but usually if somebody is having an issue after just a couple of weeks I say don’t wait because there’s things that are happening that your body should be recovering and at that point you need to start going after it.

So that’s the answer to your second question there, and then the first one and around the causes, so I have found that there’s 15 different causes of fatigue but to be brief on it, and we can definitely get into those, generally I put them into two categories, one is things that need to be replaced or deficiencies, and so that’s things like not drinking enough water, not getting enough good sleep, deficiencies in hormones, adrenal, thyroids, sex hormones, deficiencies in nutrients like B12, vitamin D, magnesium. And then the second part is excesses, so we’re talking about things that need to be removed, the crap that’s in the body that needs to be removed out that’s causing problems, so we’re talking about heavy metals, chemicals, molds infections, allergies, negative emotions, electromagnetic frequencies, hidden dental infections, parasites, so a bunch of that crap that’s not supposed to be in the body that’s just draining the body and causing all these deficiencies.

Dr. Weitz:            Yeah, a famous Functional Medicine doctor basically said, “It’s pretty simple, what do I not have enough of and add that and what do I have too much of and get rid of some of that.” I think that was Dr. David Jones.

Dr. Hirsch:           Yeah, that’s exactly right. What I find with a lot of docs, they have that theory but they’re not looking enough at molds. They don’t have enough knowledge around mold illness, how to diagnose it in a person, how to diagnose it in a home to make sure they’re not living in a home, what that process looks like and then infections. You really have to dive in there in order to get that knowledge beyond just what Dr. Jones said.

Dr. Weitz:            Yeah, absolutely, and the tricky part is that you could spend a lifetime just studying mold, you could spend a lifetime just studying heavy metals, and so each time you get into one of these specific topics as a functional medicine practitioner it’s like jumping down a new hole of a whole new set of things to learn about, and that’s the tricky part. You tend to find what you’re familiar with, so if you’re really comfortable dealing with heavy metals it’s easy to find heavy metals, and most people have heavy metals so you fix those and you’re gonna get some improvement.

Dr. Hirsch:           Right, exactly, and that is a problem with being a clinician is we always have to catch ourselves and make sure that we’re just not leaning on what we enjoy treating or what some of these old patterns are and really trying to be as expansive as possible. And so for me what I have people do when they first come to see me is I have them run a whole bunch of labs because I know my clinical suspicion and I can diagnose some things clinically but neuropathy, fatigue, I mean a lot of these things it could be multiple things. And in fact, with everybody that I see I tell them, “There are 15 potential causes, you have multiple causes of fatigue and the causes that you have are different than the person in the next room.”  So we all have different multiple causes and they’re all different from each other which makes it so hard to treat, so it’s really important to get all of those things assessed, the heavy metals, chemicals, molds and infections, looking inside the body, making sure and seeing whether or not they’re there, putting them together with the symptoms and then coming up with a plan and having the right tools in order to treat them effectively.

Dr. Weitz:            And one of the things that I find challenging in Functional Medicine is when patients come in with the conventional mold, they’re realizing, “Well of course I realize it’s gonna be a little bit different,” but basically they want to take the test, they want to be told it’s this, they want to take those pills and that’s it, I’ll see you, and the problem is these are a lot of times complex cases and there are levels of dysfunction. So if the person has mold but they also have a leaky gut and they also have nutritional deficiencies, and you can’t address all these at one time so you sort of have to prioritize, deal with some of the most significant ones first and it’s a different model than you’re used to going to their medical doctor.

Dr. Hirsch:           Absolutely. I tell people this is a marathon, it’s not a sprint. This is a long-term proposition and it’s gonna require a lot of information or a lot of buy-in from them, and the people who come to see me have already seen 20, 30 doctors and so they’re probably different maybe than the people who come to see you but they’re usually a lot more bought in than when I was just practicing functional medicine now that I’ve ditched myself in this way and people are coming to me for chronic fatigue.

Dr. Weitz:            I see, interesting. I was reading your book which is an excellent read, lots of good information, easy to read and you talk a lot about adrenals in one of the first chapters, can you talk about how important adrenals are to fatigue? And how do we assess adrenals? And what do we do about adrenals if they’re burned out or not functioning optimally?

Dr. Hirsch:           Absolutely, and this is one of the things that I do at the first visit. Generally even without labs I can tell whether or not someone has the symptoms of adrenal dysfunction, and to answer your question-

Dr. Weitz:            Do you ever have patients do a series of labs before they even come in?

Dr. Hirsch:           I don’t.

Dr. Weitz:            Okay.

Dr. Hirsch:           Yeah, they could. A lot of people come with their own labs but I don’t because I want to make the assessment and I want to make sure that I’m ordering the correct labs for them, but the adrenals are really a universal problem. The adrenal gland produces lots and lots of hormones, cortisol is the big one that we talk about a lot that manages stress, it manages the immune system, it manages inflammation, everybody’s heard of prednisolone and cortisone, well guess what? They come from cortisol and that’s our body’s natural anti-inflammatory. So whenever there’s inflammation in the body like from eating gluten or eating dairy or having an infection or having mold, cortisol goes and some of the other adrenal hormones go and try to put out that fire, and as a consequence those hormones coming from the adrenal gland end up going down and people will have low blood pressure, they will crave salty and sweet things.  Generally they’ll say, “I can’t walk past a bag of potato chips without having to stop to eat it.” And then with the low blood pressure they’ll kind of have dizziness when they go from a sitting to a standing position too quickly. They will have low energy throughout the day, but typically they’ll crash usually at around eleven o’clock or at around three o’clock. Three o’clock is the big one where people are like, “Man, between 2:00 and 4:00 I have to take a nap. I have to get some chocolate, pick me up, caffeine, 5-hour energy.” Whatever it is, that’s really when they’re crashing, or they exercise and they have exercise intolerance where they exercise and then they’re crashed out for two days and they’re like, “I thought exercise was supposed to be good for me.” It’s like, “Yeah, but if your adrenals aren’t working well your body can’t manage the stress of that exercise.”

For those of you who don’t know, the adrenal gland is a little triangular gland, sits on top of the kidneys, produces cortisol and some of these other hormones which regulate so many parts of the body, so important and really the sentinel gland. As the adrenal gland goes, so goes the thyroid, so goes the sex hormones, so its really so pivotal, so important. So that’s the anatomy of the adrenal gland, the symptoms that you’ll get with it, and then in terms of testing like I said, I can tell really based off of their symptoms but sometimes you’re looking at a morning cortisol level which is what I do in blood but you can also look at saliva to look at four times a day, but those are kind of the big ones.

Urine can be helpful looking at urine metabolites from the adrenals, so all of those can kind of give you a glance. I do believe that looking at the symptoms are most important. And then in terms of treatment, I’ve tried lots of things over the last 10 years and I’ve dumped all of my protocols into the book, you can read more about this but I found that there’s this one product called Adrenal Px by Restorative Formulations that’s Eleuthero root, Hawthorn root, but mainly the Eleuthero root that’s super smooth and super strong that I have people take every three hours until 4:00 PM and it makes a world of difference in their overall function. It’s really the first thing that I do when you talked about the common causes, one of the most common causes is adrenal dysfunction, maybe it’s cortisol, maybe it’s some other components of the adrenal gland.  But starting to work on that adrenal gland, starting to work on sleep, behavior, food, those are kind of a lot of the big things that I do initially that can make a huge difference in people’s lives.

Dr. Weitz:            Cool, there’s a lot of discussion these days about checking the cortisol within like the first 30 minutes of waking up, it’s called the cortisol wakening response, and so now some saliva tests. You actually spit into a tube before you even get out of bed and apparently you get the most accurate assessment of cortisol apparently using that test now.

Dr. Hirsch:           Interesting. I’ve got a free Facebook group with almost 1,000 people in it and I just did a Facebook live review of some of the work that Ari Whitten did at the Energy Blueprint. He basically looked at all of the research on cortisol and its association with fatigue, and I think most of the research was on blood and on salivary, probably wasn’t on this new technology, but what he found, and time and time again, I mean he went over like, I don’t know, almost 100 different papers and meta analyses and there’s really no correlation between low cortisol levels and fatigue.

Dr. Weitz:            Interesting.

Dr. Hirsch:           Yeah, and so what I really think is happening is that there’s a number of these different components, these different hormones that are being produced by the adrenal gland, epinephrine and norepinephrine which are like the adrenaline hormones, maybe they’re playing a bigger role but utilizing just cortisol to determine someone’s adrenal function really hasn’t been proved and has been disproved in the research to be effective and functional. So we need some better tools but in the meantime I do use it and I combine it with symptoms, making sure that … Because those symptoms can be very specific for the adrenals.

Dr. Weitz:            How often do you actually prescribe cortisol itself?

Dr. Hirsch:           Great question, so like hydrocortisone, Cortef , some of those prescriptive agents?

Dr. Weitz:            Yes.

Dr. Hirsch:           So I have a tiered approach where I’ll start off with giving people Adrenal Px and then if they need I’ll ramp up to three capsules per dose, four capsules per dose. If they need more support I will put them on the Adrenal Px syrup which is a little bit stronger, and then if they need more support beyond that oftentimes and they have low blood pressure I’ll add in a little bit of licorice root and then I’ll move into a product called Adrenal Para-NS by Byron White Formulas, and then I’ll get into hydrocortisone. So there are problems with hydrocortisone, it is a steroid. I mean cortisol is also a steroid, we’re making our natural steroids but it can cause people to put on weight.  They get a little bit of this chipmunk appearance with the jowls and often times they may get a bit of a hump on the back and they do put on the weight and they do start craving a lot more food which causes them put on the weight. So it’s not perfect, there is a book called Safe Uses of Cortisol by William Jeffries where he did use it long term, and I have used it long term with some people but the goal is that it really is just a band-aid, because when we figure out what’s causing stress on the body and that could be a mental, emotional stress or it could be physical stressors like all that crap that’s in the body that I talked about before, once we remove those it allows the adrenal gland to relax. It doesn’t have to produce all these hormones and you shouldn’t need as much of the adrenal support.

Dr. Weitz:            Cool, now another important gland that affects energy levels is thyroid, can you talk about that a little bit? And how often is that playing a role?

Dr. Hirsch:           Absolutely. Thyroid dysfunction is huge and part of that has to do with the fact that low thyroid is really two conditions, it’s low thyroid production by the thyroid gland and then it’s also an autoimmune condition. So the immune system is attacking the thyroid, and usually it’s because one of those crap things, what I call the usual suspects, heavy metals, chemicals, molds, infections, allergies, emotions, EMFs, they’re all in the thyroid and so the immune system is trying to get rid of the stuff in the body that’s not supposed to be there. So it goes on over to the thyroid, calls its friend, starts attacking the thyroid to get at what’s in the thyroid, usually it’s mercury, maybe it’s Bartonella which is this particular kind of infection.

It grabs at it, tries to pull it out, oftentimes not successful because they’re so sinister but that’s kind of the process and in that process you’re destroying the thyroid and you get lower levels of thyroid.  So in order to fix it you have to remove the crap that’s in the thyroid, that’ll slow down the destruction of the thyroid or stop it.  Immune system is no longer gonna react to it and consequently you’re not decreasing your thyroid levels. Now, I do like to use prescription grade thyroid when I am replacing the thyroid.  I’ll start off with some natural things, some thyroid glandular or some iodine or kelp or some of these other things, but generally I find that I get the biggest shifts when I dive into using the prescription agents.

Sometimes people need more T4, sometimes people need more T3.  People who just use Armour or Nature-Throid or Westhroid, they’re missing the boat, that’s basically like a combination of T4 and T3 but everyone’s an individual and most of the time those people who come to me on Nature-Throid or Armour, they need more T4 or they need more T3. We have to figure out the right dose for that individual, and this combination product is not a one-size-fits-all, but thyroid plays a huge role. You also support the thyroid with the adrenals, and there’s this beautiful dance that happens between thyroid, adrenals and sex hormones, and they really all have to be present and accounted for in order for the whole system to work.  So somebody steps out of the dance like when you have stress with the adrenal gland and that’s gonna tax the thyroid and the sex hormones or you get above 50 and all of a sudden the gonads start to shut down and sex hormones start to go down. If the adrenals aren’t robust enough, they’re supposed to take over production of the sex hormones, but if they’re not robust enough, then both the adrenals and the thyroid will start to decrease their function as well, as they try to scramble and compensate for each other.

Dr. Weitz:            Do you find that gluten is sometimes playing a role where the body immune system attacks the gluten and then you get this cross reactivity with the thyroid?

Dr. Hirsch:           Yes, gluten definitely plays a huge role, gluten-

Dr. Weitz:            Soy.

Dr. Hirsch:           … dairy, soy, corn, genetically modified corn, those are kind of the big ones that I see but the only time I’ve ever been able to really reverse thyroid and to get people off of their thyroid medication has been going after infections and heavy metals. There’s one particular infection called Bartonella, this is a funny, serendipitous story where I had a patient who I had just put on a treatment for Bartonella. Now Bartonella is this infection that causes a combination of symptoms usually a combination of headaches, neck pain, problem sleeping, anxiety, depression, pain on the bottom of the feet, muscle cramps in the calves, stretch marks sort of rash on the body and thyroid issues, and so you don’t have to have all those you just have to have some of those. The big ones are like pain on the bottom of the feet usually misdiagnosed as plantar fasciitis and the muscle cramps.

But I put somebody on treatment for Bartonella and she comes back in like the next day and she’s in a thyroid storm. So she was on thyroid medication, I started her on this path and now she’s got too much thyroid, she’s like hyper thyroid. Her heart is beating out of her chest, she’s got tremors, she can’t sleep, she’s anxious, agitated, I said, “I don’t know what’s going on but we got to decrease your thyroid because you’re hyperthyroid.” So we decreased her thyroid and over time as we ramped up on treating her Bartonella we were able to wean her completely off of her thyroid medicine, which I’d never been able to do before.  I never heard of anybody being able to do this before, so it was very exciting.  And so I find that about 50% of people who have thyroid issues who also have Bartonella, I’m able to get them off or wean down off of their thyroid medication, maybe not all the way but a significant way down off of their meds.

Dr. Weitz:            Very cool. What kind of treatment did you use for the Bartonella?

Dr. Hirsch:           So I’m a big fan of Byron White Formulas. He’s just done an amazing job with his herbal complexes, and so A-BART is really one of my favorite formulas which has neem in it and poke root and a number of other things to break up biofilm, to kill the infection, to push it out of its hiding form.  It’s incredibly potent, so even just one drop can send people into a die-off or a Herxheimer reaction where you’re killing the bug and you feel worse, and so sometimes I even start people off topically, just rubbing it into their hands can make a huge difference for folks, but his formulas are really genius and I love to use them.

Dr. Weitz:            Interesting, yeah. I interviewed Darin Ingels who’s an expert on Lyme disease and he mentioned the Byron White Formulas as one of the formulas that he’ll use, and I guess Bartonella is often talked about as a Lyme co-infection.

Dr. Hirsch:           Exactly, yeah. Acutely it’s cat scratch fever, where people get big lymph nodes and they get fevers but chronically, yes it can exist in ticks and fleas and mosquitoes and all these things that transfer Lyme.  And I find that I don’t have to treat Lyme or Borellia as much when I’m going after these co-infections, whether it’s Bartonella, whether it’s Babesia that will cause people spontaneous sweating, shortness of breath, cough, awful panic and anxiety as well as depression and suicidal thoughts. I go after those guys and I don’t have to really go after the Lyme, Borellia as much because then the immune system will come back on board.  I get rid of the molds and the heavy metals that brings the immune system back even more, because you really can’t treat these infections until you get rid of the heavy metals, chemicals and molds that have distracted the immune system. So you got to bring that immune system back in order to bring these bugs back into check.

Dr. Weitz:            Cool, I noticed you were talking about using 20,000 units of vitamin D sometimes for patients with thyroid problems, that’s pretty high dosage, do you find that to be necessary to go that high?

Dr. Hirsch:           Yes, and it really depends on what we’re doing, but when we’re looking at the thyroid and we talked about it being an autoimmune disorder, one of the ways in order to modify the immune system and what’s called the Th1/Th2 balance. One of the aspects of the immune system is causing this autoimmune component, and you can adjust that by dealing with the T regulatory helper cells and you can do that with high dose vitamin D, you can do that with glutathione, you can do that with low dose Naltrexone.  So there’s a number of different strategies that we can use to bring that seesaw back into balance and decrease the amount of autoimmunity that’s happening to the thyroid.  And there’s been lots of studies on vitamin D and I know doctors who try to get people’s levels up to 100 or 150 units on the blood and I’m really looking for more 60 to 100 but people are so deficient that you can give them 20,000 and oftentimes it’s not gonna put them into excess of 100. Most people live at around 10,000 but yeah, 20,000 is also really great for colds, boosting that immune system so that it’s able to function at a higher level.

Dr. Weitz:            Yeah, you probably noticed patients who’ve been to their medical doctor who tested their vitamin D and they said, “Oh yeah, I’m taking plenty of vitamin D. I’m taking 1,000 units a day.

Dr. Hirsch:           Right, yeah it’s almost comical. And the levels when we’re looking at those labs, normal range is not a normal range. It’s not an optimal range, it’s a population-based range, so I’m always telling people … Because a lot of those labs say yeah, less than 20 is low for vitamin D and I’m saying less than 60.

Dr. Weitz:            Yeah, exactly. There was just a study that showed that women who got their vitamin D above 60 had the lowest risk for breast cancer. I noticed you mentioned PEMF which is a kind of electrical machine, right?  And you sometimes use that for patients with thyroid issues.

Dr. Hirsch:           I did. I was experimenting it for a while, probably around that time that I was writing the book. I don’t use it a lot, in part, because some of the ones that I’ve used have just been too strong for a lot of my patients. It opens up the capillaries where you’re able to absorb things a lot better and you’re able to detoxify and I really need more control over detoxification because a lot of my patients were feeling worse. It was also very dehydrating for them and when you have adrenal issues you don’t maintain your salt balance well and so consequently you’re chronically dehydrated, and so it was just a little bit too much. I was using the BEMER technology and some of those and it was just too strong on people.

Dr. Weitz:            You might look into using cold laser. There’s a research group out of Brazil that’s published several studies using cold laser directly over the thyroid, there’s a certain protocol and they’ve actually been able to show changes in the cells and actually reverse Hashimoto’s in some cases.

Dr. Hirsch:           Wow, I’m writing that down right now.

Dr. Weitz:            Yeah, I’ll send you a copy of one of the papers afterwards.

Dr. Hirsch:           Great, thank you.

Dr. Weitz:            So you also talk about trying to balance the sex hormones as something to look at when patients are suffering with chronic fatigue, maybe you could talk about that.

Dr. Hirsch:           Sure, so sex hormones, generally I’m looking at that for people who are over the age of 50, but when mold is introduced it’s incredibly common in any age, especially scratched my head for a while, I’ve had all these men that had low testosterone levels, low libido, stuff like that, turns out that most of those had mold and once we got rid of the mold then the libido came back, the testosterone levels came back up. So it really is about where’s the stress on the organism? How are the adrenal thyroid sex hormones playing a role? Can we do it with herbs? Sometimes I’ll use maca and different forms of maca to boost estrogen, progesterone, testosterone, but sometimes I’ll need to go …

I had a patient today in my office who I needed to give bioidentical hormones. So she’s 47 years old, she’s moving into menopause, she’s got hot flashes and sometimes in the interest of time and in the interest of helping somebody resolve their symptoms I’m like, “Okay, we’re gonna boost your adrenals and while we’re boosting those I’m also going to give you this symptom relief because this is gonna make everything work better as we remove these toxins out of your body.”

Dr. Weitz:            Cool, yeah. One of the problems I think is all these endocrine disrupting substances in the environment.

Dr. Hirsch:           Yeah, we tested her for toxins and we found that there were a bunch of organophosphates, so pesticides that were found in her urine in addition to some mycotoxins or mold toxins that were there too.

Dr. Weitz:            Yeah, I’ve tested hormones on about 20 men in the last several months and like 17 of them were low, especially in their free testosterone, even called up the lab and said, “Is there something wrong?” But I think it’s getting to be really common that these endocrine disrupting substances and potentially mold and heavy metals as well are interfering with testosterone production.

Dr. Hirsch:           You got it right there. Yeah, and they’re all stressing out the hormone system which is really … When it comes to options in the body, I tell people, “Does your body want to survive or does it want to procreate?” And right now it just wants to survive. It’s dealing with all that crap coming at it, it’s stressed out of its gourd and it’s gonna send as many of its resources as possible over to the adrenals, to the thyroid, and it’s not going to worry about the production of testosterone. You can actually see that also when you’re looking at the steroid hormone pathway, that half of it is kind of like adrenals and the other half is sex hormones and you can see how it would be diverted.

Dr. Weitz:            So let’s say you have a patient with chronic fatigue and you’ve looked at the thyroid and adrenal and maybe even addressed the sex hormones, and now you’re starting to think, “Okay, could there be an infection or maybe heavy metals or mold,” and there’s nothing really clear in their history, how do you decide which way to go?

Dr. Hirsch:           So that’s where the labs come into play, because I’ve definitely been proven wrong. And actually another person I had today, I was like, “Well there is no history of known mold exposure.” Now most people don’t ever think that they’ve had mold exposure unless it’s been on the wall, and so I have to ask them, “Okay, have you ever lived in a place that had a leak in the roof or had a flood in the basement or had a broken pipe?” And then people say no and then inevitably they’ll come back the next time and say, “You know what? I think I did.” But it’s so nebulous and it could be that it was a place that they were growing up when they were five and they don’t remember. And so it’s all about the testing, it’s all about having good tests in the urine mycotoxin which is looking at the mold toxins is really the best test out there.  Now you have to propagate it with glutathione so you have to make sure that somebody’s taking glutathione so that they can push all of the micro toxins out and make sure you get a good test.

Dr. Weitz:            Oh, interesting. How much and how long do they have to take the glutathione for before you do the urine test?

Dr. Hirsch:           So seven days, 500 milligrams of liposomal glutathione twice a day, so that’s like a teaspoon twice a day of the ReadiSorb glutathione or the Tri-Fortify liposomal glutathione by Research Nutritionals, and so either one of those should work but seven days or however long. If they can’t take it for seven days because they start to feel like crap because they’re mobilizing all this crap that’s in their body, then just have them take it on that day so that they don’t have to suffer, but generally seven days, twice a day, 500 milligrams and then they do that test but that’s the urine test for the mycotoxins, the urine provocated test for heavy metals utilizing DMSA, really the best ways to get these things out of the body so that you can test them and determine what’s going on.  The PCR tests are basically a DNA test for a lot of these Lyme type infections in the urine through DNA connections is the best test out there. So there are a number of different tests but you got to make sure you’re looking at the right one.

Dr. Weitz:            Which test do you use for the mold? Do you use the Great Plains mycotoxin test?

Dr. Hirsch:           I’ll use both of them, the Great Plains or the RealTime Labs but Great Plains, less expensive, does a great job, I really like what they’re doing. RealTime Labs is covered by Medicare, they also do a great job and they’re expanding their panel a little bit more but I’ll use either one but the Great Plains is less expensive.

Dr. Weitz:            Cool, and then how do you assess for heavy metals?

Dr. Hirsch:           So I’ll use Doctor’s Data, looking at the DMSA provocation test where people take 10 milligrams per pound of body weight, so if they’re 200 pounds or over they’ll take 2,000 milligrams. But I do a pre and a post, so you wake up in the morning and you check your urine and that’s the pretest and that tells you what’s floating around in the bloodstream, and then you take 2,000 milligrams or whatever your weight is of the DMSA and then that’s gonna start pulling out the heavy metals from the tissues, from the organs, because that’s where the heavy metals live. They don’t live in the bloodstream, that’s why when you do a blood test for lead it’s really worthless, blood test for mercury, worthless.

You have to pull it out from the tissues and then you check it in the urine, you collect the urine for the next six hours and then you compare the two and that can give you some really good information as to whether or not someone has a heavy metal. And then there’s a lot of nuances to it because if they’re detoxification pathways are really clogged up with molds or chemicals then they’re not going to have a very positive results or if you detoxify them for a period of time then all of a sudden they’re gonna be releasing a lot more mercury, so they’re going to be like, “Why is my mercury getting worse?” Well it’s not getting worse it’s just that when you were detoxifying initially you could only get rid of up to this amount of mercury, but now that your detoxification pathways are so much open now you’re able to get rid of so much more mercury out of your body. So there’s a lot of nuances to that and I do talk about some of that in my book.

Dr. Weitz:            Interesting. Is there a way to screen for some of the other chemicals besides heavy metals, like the endocrine disrupting substances.

Dr. Hirsch:           So I use the Great Plains Lab, they’re GPL-TOX tests which looks at kind of a hundred different chemicals and that’s a really great test as well, and also should be provocated with the glutathione.

Dr. Weitz:            Okay, great. And then how do you get rid of heavy metals?

Dr. Hirsch:           So that is a great question too, so there are some more aggressive techniques or some more gentle ones. You can use things like saunas and coffee enemas and cilantro and chlorella and modified citrus pectin. I use a combination of products by Byron White. A combination that opens up the liver and kidney pathways, helps open up lymph neurolymph so basically lymph that’s in the brain, and our lymph system is really our garbage can or trash system that really helps to move things through, and then a product that he’s got called Envi-Rad which helps to get the metals out as well as the chemicals.  And in a study that Byron White did on his patients, he found that over a 10-day period when he combined all of these products he saw a 300% increase in excretion of metals in the urine which is pretty darn equivalent to doing it with DMSA which has a lot more side effects and consequences, and you have to make sure that you’re replacing a lot of the minerals and a number of other things. You have to protect the liver and the kidneys while you’re doing that so it has a lot more nuances to it, and so I’ve been very pleased with using this Byron White protocol.

Dr. Weitz:            Cool, how long does that protocol typically take?

Dr. Hirsch:           So it depends on the person, generally the people who are coming to see me need to do it for sometimes six months, sometimes 36 months, so it really depends. I tell people, I say, “I’d like to get you better in a year but depending on the number of causes you have and your ability to tolerate these supplements that I recommend will determine on whether it’s a year or whether it’s three years.”

Dr. Weitz:            Now, do you look at the guy to make sure that they are not constipated, so they’re actually excreting these toxins to make sure they don’t have a leaky gut so they don’t get reabsorbed.

Dr. Hirsch:           That’s a very important point. Nobody should ever be doing any sort of detoxification unless they can get things out of the body, and that means that you’re peeing regularly, you’re pooping regularly, that you’re sweating regularly, that you’re able to exhale. Those are the ways that we detoxify our bodies and so you have to be able to be stooling on a regular basis, once or twice a day. And so I’ll use magnesium to bowel tolerance, but a lot of times when … Constipation has a cause, it could be thyroid and I kind of have a chapter, I’ll dedicate it to this in the book. It could be thyroid, it could be parasites, it could be yeast, it could be a number of these infections that I test.  I really like that GI-Map stool test, really works well.

Dr. Weitz:            Yeah, we’ve been using that a lot too.

Dr. Hirsch:           Yeah, and it gives you a lot of good data and then you can determine whether or not you need to fix it, but everybody that I see has got a leaky gut because they have all these causes of fatigue which also all damage the gut, so there has to be some leaky gut repair. But I found that I’m just wasting time and money to try to heal leaky gut when someone’s got heavy metals, chemicals and molds. I can heal the gut at the same time as going after the fatigue by going after parasites or yeast, but it just doesn’t make a lot of sense for me when I’m treating these really sick people to go after that leaky gut and spending a lot of time there.

Dr. Weitz:            Yeah, especially if their primary symptom is not gut related so you have to prioritize.

Dr. Hirsch:           Exactly.

Dr. Weitz:            Yeah, so the final topic I want to touch on is mitochondria which is that part of the cell that’s truly responsible for producing energy, can you talk about how we think about the mitochondria with respect to fatigue?

Dr. Hirsch:           Absolutely, so the mitochondria like you said is the energy center of every cell in the body except for red blood cells, they don’t have them, but it produces about 70 to 80% of our energy, our ATP as it is. And so the mitochondria comes from a bacterial ancestor, it has this very important mitochondrial membrane which can get damaged by heavy metals, chemicals, molds, infections, allergies, emotions, EMFs, like all these things are going to damage that mitochondria, and so not only do we have to remove that crap off of the mitochondria but we also have to inject the mitochondria with some good love in the form of like Acetyl-L-carnitine, L-carnitine and D-Ribose, CoQ10.

There’s a number of things that I really like to use but the most important thing I think is also to heal that mitochondrial membrane, because what people forget sometimes is that around that cell, that membrane, is the communication tool for other cells, so there’s these ion channels, there’s these messengers that need to be working, and so one of my favorite products is ATP Fuel by Research Nutritionals which does wonderful things for healing the mitochondria and then repairing that mitochondrial membrane. And they did a study on 58 people, and after the saturation you’ve got to boost it up, taking it twice a day for the first two months but after the first two months they saw a 30% average increase in energy.  So just a really nice bump of one or two points of someone’s energy just from doing that, now imagine if you’re also boosting the adrenals, boosting the thyroid, B12, vitamin D, magnesium and then also removing the crap out of the body, you’re gonna get a lot better energy and a lot better function.

Dr. Weitz:            Cool, I feel more energetic already doc. So thanks for the interview Evan, this is really good. How can listeners get a hold of you?

Dr. Hirsch:           So you can find me at fixyourfatigue.org, F-I-X-Y-O-U-R-F-A-T-I-G-U-E.org. You can also check out my free Facebook group which is Fix Your Fatigue With Dr. Evan, you can find that from my website as well. I do have a free download on my website of my book, so if you want to get it on Kindle or on Amazon as Kindle or paperback you’re more than welcome, but you can also download the PDF for free, and I’ve really dumped all of my protocols into there so you can figure out how to solve your fatigue. And I do have about 10 spots available for one-on-one and group coaching right now, so if people are interested I’ll be filling that up in the next month or so. But otherwise, I’m on a mission to help a million people resolve their chronic fatigue so thanks so much for having me on and helping me with my mission.

Dr. Weitz:            Cool, that’s great, that’s a great mission doc. Talk to you soon.

Dr. Hirsch:           Thanks so much.

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Detoxification with Dr. Bob Rakowski: Rational Wellness Podcast 69
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Dr. Bob Rakowski talks about how to detoxify your body with Dr. Ben Weitz. 

[If you enjoy this podcast, please give us a rating and review on Itunes, so more people will find The Rational Wellness Podcast] 

 

Podcast Highlights

3:35  Environmental toxins are so insidious, that we just can’t avoid them.  Dr. Federica Ferrara is a researcher from Columbia University, who’s been studying this for over a decade and she literally took air samples from very sophisticated mechanisms that she had pregnant women wear all over the country and every single woman, every single day, was exposed to these neurotoxins that were known to cause harm to the developing fetus.

4:44  We can start by detoxing our kitchens and don’t buy any unhealthy, processed foods that you shouldn’t be eating, so you remove temptations.  We also need to be concerned about all our exposure to wifi and electromagnetic forces, so unplug your wifi, have a digital sunset, have a day without any electronics, to give our brains a rest.

7:32  In order to detox our bodies, Dr. Bob has been talking about the magnificent seven–You gotta eat right, drink right, think right, move right, sleep right, poop right, talk right, every single day.  So, when we’re gonna eat right, we want to avoid the toxins and yet we want to get the nutrients that help our body to cleanse, so detox is a very nutrient dependent, and believe it or not, protein dependent process. We also want to make sure you are pooping right, since this is how we get rid of toxins. Dr. Rakowski also mentioned one of his favorite quotes, from Jack Lalanne, who happened to be a chiropractor, he said, “If God made it, it’s okay; if man made it, don’t touch it.”  “Move right actually helps to detoxify. There’s no doubt about it that movement, we’re gonna exhale, we’re gonna blow off carbon dioxide, we’re gonna sweat, that’s a pathway.”

12:10  Poop right means that you should go at least once a day and preferably multiple times.  You should have enough fiber so it goes through easy.  What controls bowel function is fiber, water and neurologic tone.

13:20  Talk right–every cell’s in communication with every other, so we gotta make those cells right and flexible and responsive and have the right acid alkaline balance. Acid is the top toxin that we make.

13:30  Sleep right, since we detoxify our brain and body when we sleep, and we go through a liver detoxification in the middle of the night. 

14:12  If we don’t have good digestive function and we are not pooping regularly, then estrogen and toxins that need to be eliminated will get reabsorbed. And if we have leaky gut, as one in two people have, these toxins will pass through the gut wall directly into the blood stream.  Dr. Rakowski says “You are what you eat, and that’s pretty true. You are what you absorb, that’s more true. You are what you don’t eliminate. That’s most true!”

17:58  In order to facilitate liver detoxification, Dr. Bob likes to have his patients do a seven day detox with Medical Foods, like the Ultraclear Renew from Metagenics, and organic, non-starchy vegetables only. If you try detoxing by fasting, within 24 hours of the fast, since the liver is protein and nutrient dependent, liver detoxification will slow down by 50% before you start breaking down your own tissue. Some people try to do liver detox with food and he quotes a study from the Journal of Advances in Therapy that found that food is too weak to replete the depleted cells and bodies, therefore supplementation is advisable for everybody.  Dr. Rakowski has treated hundreds of high level celebrities, professional athletes, and Olympians with his 7 day Medical Food detox and he has found that many of the Olympians set a season or personal best within a week of completing the detox.  He recommends doing this one week intense detox twice per year.

26:58  Too many in our society don’t get enough sleep and Dr. Bob likes to use calming adaptogens and theanine from green tea, which is a GABA facilitator and is very calming. People need a sleep routine and a dark, cool room without wifi.  The best of the best need 8.6 hours of sleep per night.  Dr. Rakowski personally takes 50 mg of timed release melatonin at bed. He mentioned an NIH study in which they administered 50 mg of melatonin and vitamin D and they found that it prolongs survivability and prevented lean tissue breakdown in inoperable cancer patients. Melatonin does not cross the blood brain barrier.  Dr. Rakowski notes that in the last decade his biological aging has been very slight.

 

                        



Dr. Bob Rakowski is a Doctor of Chiropractic, Certified Clinical Nutritionist, and the director of the Natural Medicine Center in Houston Texas. Dr. Rakowski is available for consultations in person or remote via Skype or Zoom and he can be reached through his website, http://thedrbob.com

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.


 

Podcast Transcripts

Dr. Weitz:                            This is Dr. Ben Weitz with the Rational Wellness podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to Rational Wellness podcast on iTunes and YouTube, and sign up for my free ebook on my website, by going to drweitz.com. Let’s get started on your road to better help.  Hey Rational Wellness podcasters, thank you so much for joining me again today. For those of you who enjoy the Rational Wellness podcast, please leave us your ratings and your review on iTunes so more people can find out about the Rational Wellness podcast.

Our topic for today is toxins and how to remove them by conducting a proper detoxification program. Our modern world has many toxic substances in the air, food, water, as well in products … as well as in products that we cook with, clean our homes, apply to our skin, hair, teeth and various other personal care products, products that we use on our lawns, and products that we use in construction and painting our homes.  We often find fluoride, chlorine, and sometimes ammonia that are purposely added to our public drinking water as well as small amounts of prescription medicines. We’ve all heard about the lead in the water in Flint, Michigan, but other … But a recent scientific American report found thousands of cities across America with toxic levels of lead in your drinking water. A recent report from the Environmental Working Group demonstrated that there are toxic levels of PFCs, a certain type of chemical, in the drinking water of 15 million Americans in 27 different states.  These PFCs are chemicals that come from nonstick cookware, such as Teflon coated pans, stain resistant coatings on carpets, upholstery, and clothing such as scotch guard, lining fast food containers, pizza boxes, candy wrappers, and microwave popcorn bags. These are also in paints, sealants, anyway, I could go on and on about toxic chemicals in our modern environment, and these chemicals make our way into our bodies and often, are stored there.  The Environmental Working Group conducted a study in 2009 that found measurable levels of BPA in umbilical cords of nine out of ten infants, as many as 232 chemicals were found in the umbilical cord blood of infants before they even stepped foot in the world. I’m glad that we have Dr. Bob Rakowski with us today to give us some information on how we can start to get some of these toxins out of our bodies.

 Dr. Bob Rakowski is a chiropractor, kinesiologist, certified clinical nutritionist, certified biological terrain instructor, and the clinic director of the Natural Medicine Center in Houston, Texas. In addition to running a busy chiropractic and functional medicine practice, Dr. Rakowski has lectured internationally for over 25 years on various topics in natural and lifestyle medicine. Dr. Bob, thank you so much for joining me today.

Dr. Rakowski:                     You’re welcome. I tend to like to smile whenever I’m on camera, but I probably couldn’t help but have a scowl as you were sharing the grim reality of these toxins that, literally, it’s been said, environmental toxins are on the attack, because they’re so insidious. We just can’t avoid them, and in fact, if you don’t mind me throwing out a little research, there’s a researcher from Columbia University, Dr. Federica Ferrara, who’s been studying this for over a decade and she literally took air samples from very sophisticated mechanisms that she had pregnant women wear all over the country and every single woman, every single day, was exposed to these neurotoxins that were known to cause harm to the developing fetus.  And so, we’ve gotten to the point where, you know what, they’re everywhere, so what do we do about it? I guess that’s the topic for our beautiful conversation today.

Dr. Weitz:                            Exactly, exactly. So, what can we do to … Before we go into detox, what kinds of … What do you think are some of the most important things we can do to try to avoid being exposed to these toxins?

Dr. Rakowski:                     Well, you said a lot of things right there, so the number one rule in toxicology is to separate yourself from the toxic source. So, maybe the first thing you want to detox is your kitchen.  There’s a great mentor out there, his name is Bryan Tracy, he asks a couple of simple questions. What’s the one thing that you can start doing that you haven’t been doing that’ll improve your life the most? And what’s the one thing that you can stop doing?

Well, we can do the same thing with nutrition. Most of us are going to make faster progress by stopping putting garbage in our body and if you’re like me, I can resist almost anything but temptation, so if it’s in my kitchen, there’s a little bit of a challenge. I’m more likely to take it then. So, get your, buy your willpower by either shopping online, sending someone else to the store, stay in the periphery, don’t go down the center aisles with all that packaged garbage.

So detox your kitchen and have strategies there, but we’re taking advantage of this beautiful communication medium and this may be beyond the level of what we’re talking about in terms of chlorine from our body, but we’re exposed to wifi and electromagnetics and things at a level that people have just never been exposed to before, and the data shows that there’s problems. In fact, I’m a little older than you, but Henry Kissinger was Nixon’s Secretary of State-

Dr. Weitz:                            Oh, no. I remember Henry Kissinger.

Dr. Rakowski:                     Yeah, brilliant guy, but basically this guy says, “You know what, the disease of the modern century with all the exposure is actually gonna be insanity because our brain never unplugs from the input and that overstimulated brain is in a very unhealthy state.” So mental illness is happening earlier and faster. So, unplug your wifi, have a digital sunset, have a day without any electronics, clean out your kitchen, and then a lot of times when people think about detoxification, they think, “Well, okay, I’ll do something to enhance my bowel function.”  But you’ve got the liver, the kidneys, the bowel, the skin, and the lungs, all such critical part of detoxification. There’s things we can do for all of them.

Dr. Weitz:                            Oh, absolutely. Everybody should unplug their wifi at night if possible, just hard wire everything, get rid of wifi as much as you can, don’t have your phone in your room. Don’t have your alarm clock next to your bed. There’s a million things we can do. In fact, just consider the fact that if you’re laying there at night on a mattress with metal coils and you’ve got your wifi on, you’re concentrating all those radio waves-

Dr. Rakowski:                     Tell them no thank you. No.

Dr. Weitz:                            So, let’s start talking about what we can do to detox our bodies. How can we really get rid of these toxins?

Dr. Rakowski:                     All right. So for years, I’ve talked about the magnificent seven. You gotta eat right, drink right, think right, move right, sleep right, poop right, talk right, every single day.  And that poop right is kind of the elimination process, but all seven have something to do with it. So, when we’re gonna eat right, we want to avoid the toxins and yet we want to get the nutrients that help our body to cleanse, so detox is a very nutrient dependent, and believe it or not, protein dependent process.

So, if we talk about this wonderful organ called the liver, there is phase one of liver detoxification, which by the way, I like to make the analogy of that’s like burning garbage in your fireplace. So maybe let me take a step back on that. So, partly what I like to tell people is, imagine you have an old time home and you had two ways of getting rid of garbage. You could flush it down the toilet or you could burn it in the fireplace. Well, the toilet, we’re gonna call that the plumbing system, that’d be the bowel and the kidney’s and if that backs ups, guess what? We want to do something about that right away.

But if you burn garbage in the fireplace, now you gotta get the smoke out of the chimney. And so, phase one is actually burning the fire, that is an enzyme dependent process. So the liver has a series of enzymes called cytochrome P450s and there’s more than 75 that are known now, but these are all protein dependent. So sometimes people say, “I’m gonna go on a fast or a juice fast, I’m gonna detox.” Well, if the body doesn’t have the protein from your diet to detox, it’s gonna take the protein from your stores.

It’s gonna breakdown the lean tissue or possibly liver proteins, like albumen and globulin, in extreme cases, even hemoglobin, that can break down. But you don’t want your body breaking down the detox, you want to have it present with the amount of proteins that are needed, and then phase two has a lot of micronutrients. So, as you and I know and have discussed in the past, there’s literally detox formulations by really sophisticated companies where they’ve actually put it to the test. They put it through human clinical trials, exposed people to certain levels of toxins and found out, “Wow, they neutralized them and pass them through when we support them with these nutrients.”

So those are different types of medical foods or functional foods that we can do it, but when we go back to eating right, I have a couple favorite quotes. One is from Jack LaLanne, who happened to be a chiropractor, he said, “If God made it, it’s okay; if man made it, don’t touch it.” Michael Pollan, listed by people as one of the top 100 most influential people on planet Earth said, “Eat food …” Go for it.

Dr. Weitz:                            No, I was gonna say, the guy who wrote Omnivore’s Dilemma and … Yeah.

Dr. Rakowski:                     In Defense of Food, the subtitle is, “Eat food, not too much, mostly plants.” And so we break that down, I wish he’d said, “Eat natural organic food grown in nutritious nutrient dense soil, multiple colors every day, mostly plants.” So why mostly … Why not too much food? Well, we’re overeating as a general rule.  We have more people dying from overeating than starvation now and that’s the first time in the history of the planet that that’s happening. Why mostly plants? Simple enough, data from Bruce Ames Geneticist from the University of California Berkeley, people that eat the most fruits and vegetables get the least cancer. Those that eat the least, get the most cancer. So we want to get all those good plant nutrients in our system.  When it comes to drinking right, we can detoxify with drinking. I’ve got a nice detox tea here in front of me, but there’s plenty of great herbal teas. I have a big propensity towards drinking organic coffee has actually been shown in massive studies to actually increase longevity, and there’s people talking about bullet proof coffee and I actually have a way I believe of making coffee bomb proof instead of bullet proof. That could be another topic-

Dr. Weitz:                            Bomb proof coffee.

Dr. Rakowski:                     Bomb proof coffee, baby. That’s the way to go. We don’t want liquid calories, we want to detox with it, and then think right, guess what? You detoxify your mind through meditation. That’s been described as like a shower for your mind. I was sharing that this weekend at a conference. I had about 70 doctors in attendance, but I said, “Just imagine that the doctor next to you hadn’t showered today. Or maybe, how about they haven’t showered this week? Or maybe this month or maybe this year, or maybe ever?” I said, “That’s our mind. We have to shower our mind with good meditation.”

Move right actually helps the detoxify. There’s no doubt about it that movement, we’re gonna exhale, we’re gonna blow off carbon dioxide, we’re gonna sweat, that’s a pathway. Poop right, guess what, that’s certainly gonna be the bowel function and I was actually lecturing at NASA, and believe it or not, a rocket scientist asked me, he says, “Well, Dr. Bob, how exactly does one poop right?” And believe it or not, people don’t know. You gotta go at least once a day, preferably multiple times. You should have enough fiber that it goes through easy. Bowel function is fiber, water and neurologic tone, and it should have a certain color and consistency. Talk right, every cell in our body is potentially-

Dr. Weitz:            When it comes to poop, I think that digestive problems are so endemic, they’re so common in our society that I think people have forgotten what proper bowel function is. There’s, I mean, you start questioning how many people have either constipation or diarrhea or gas or bloating, abdominal discomfort, reflux, etc., it’s unbelievable.

Dr. Rakowski:                     Well, I’ll give you a stat. This is the American College of Gastroenterology. They say one in two, one in two, that could be me or you on this podcast, thank God it’s neither of us, have chronic digestive disturbance. It’s really a crime against humanity.

Dr. Weitz:                            Yeah.

Dr. Rakowski:                     Talk right, guess what, every cell’s in communication with every other, so we gotta make those cells right and flexible and responsive and have the right acid alkaline balance. Acid is the top toxin that we make and then finally sleep right, and believe it or not, we detoxify our brain and body when we sleep, and actually studies show, and Chinese medicine is known for thousands of years, how they knew I’m not sure, we go through a liver detoxification in the middle of the night.  And so we want to be asleep at that time. So, body’s have good systems. By the way, just on sleep, ’cause I’m kind of a sleep nerd, Anders Erickson, who is probably the world’s leading authority on peak performance wrote a book called Peak, and he said the best of the best of the best in any endeavor, sleep 8.6 hours a night. They nourish, rest, and recover the brain and body, and what a beautiful stat that is. So I’m a big sleep man.

Dr. Weitz:                            Yeah, some of the important things about digestion are that when we do get rid of toxins through our liver, most of those toxins are excreted through our stool and so if you’re constipated, a lot of those toxins are gonna get reabsorbed. So, something like estrogen is just gonna get resorbed and reabsorbed and we’re gonna have problems with all these toxins. So, you gotta be eliminating, so you gotta have good digestive function and then if you have a leaky gut, a lot of these toxins are just gonna cross directly into your blood stream.

Dr. Rakowski:                     And at least one in two people walking around are dealing with that challenge. Just ’cause I like words and little phrases that are memorable, most of us have heard, “You are what you eat,” and that’s pretty true. You are what you absorb, that’s more true. You are what you don’t eliminate. That’s most true. And that probably needs to raise the level of concern in some people. We want to keep those bowels moving, every single day, and preferably multiple times a day.

Dr. Weitz:                            So what are some of your keys to making sure people have a good digestive system?

Dr. Rakowski:                     Well, I’m gonna tell. It’s fiber, water and neurologic tone. And it’s also habit. So we know that bodies have routines and reality is, if people need to use the restroom, they need to know that they need to honor that reflex. So there’s a reflex that’s existent in all of us, but especially in infants, it’s called the gastrocolic reflex, and so when they eat, they poop, when they eat, they poop, when they eat, they poop. So you put something in, something comes out the back end. That seems to work pretty well.  But somehow, someway, we begin to start to suppress that reflex and then it becomes suppressed to the point where it becomes nonfunctional and we see too many people. So if they’re gonna retrain the bowel, they want to increase their fiber, they want to increase their water, and then when it comes to neurologic tone, that’s an interesting term, really muscle balance, but by stretching the colon, the colon has a stretch reflex to eliminate.  So there’s fibers and I like people to rotate their fibers and get most of them from organic fruits and vegetables, but they can certainly supplement. There’s a form of magnesium that I like a lot called magnesium citrate and it’s a very poorly absorbable form of magnesium, so it pulls water into the gut and it helps that bowel function, but people need to honor their bowels.

 I’ll tell a funny story. My kids are now 24, 21, and 20, but when my son was six years old, he already knew the importance of bowel function. So he was shopping at the mall with my wife and he always kept saying, “Mom, I have to go to the bathroom. Mom, I have to go to the bathroom.” He probably likes to shop as much as I did. But Kelly said, “Jacob, you don’t have to go to the bathroom.” He looked at her and said, “Mom, actually I do. I have to poop. Think about all those toxins I’m absorbing.” What a great point, right?  And so Kelly did just what you did, she laughed and she took him to the restroom and said, “Okay, you win. Go. Honor your body.”

Dr. Weitz:                            Did your son become a chiropractor or nutritionist?

Dr. Rakowski:                     You know what, he has a nutrition company that he owns, and actually, super proud of him, proud of all my kids, but he’s basically retired, financially free by the time he was 22 years old.

Dr. Weitz:                            Wow.

Dr. Rakowski:                     But his mother taught him well. But yeah. The picture of health as my kids are, all of them are, solid individuals that honor what they put in their body and honor the functions of their body.

Dr. Weitz:                            That’s great. So, how do we facilitate liver detoxification?

Dr. Rakowski:                     We gotta do it with nutrients. And by the way, that’s my top way of doing it, ’cause it’s nutrient dependent and it’s energy dependent, so we’re gonna start with proteins. We gotta have enough protein and it’s known within 24 hours of fast, that phase one of liver detoxification is gonna slow down by about 50% before you start breaking down your own tissue.

So some people try to do it with food and I’ll quote a study from the Journal of Advances in Therapy, they literally took people that were aged matched, health matched, gave one group an organic diet, the other group organic and supplements, they did tissue biopsies of the nutrient level at the start of the study and end of the study, people that got the best organic diet did not improve their nutrition status one bit. But people that supplemented did, so here was the conclusion. They said food is too weak to replete the depleted cells and bodies, therefore supplementation is advisable for everybody.

So, you could play it simple and go with a multivitamin, Omega 3s and plant nutrients and super foods and vitamin D and things everybody needs, but I’m a big fan of Medical Foods and functional foods. So I consume them myself, let’s say conservatively, 300 days a year. And I recommend that to my patient base as well. My rule of thumb in clinical practice, and I see some pretty amazing patients, high level celebrities and athletes and Olympians, when in doubt, detox.

So we’re gonna put people on an intense seven day detox where they’re only gonna do detox support nutrients and Medical Foods and organic diet, and then a pretty big dose. For a big guy, I might do six or seven servings of the Medical Foods a day. I’ve treated some NFL players that have done really well with that, and then at the end of the week, we see how they’re doing and … I’ve got a, literally, an interview I did with an Olympic coach and he said, “You know what, some people might think this is not a good idea in the hard part of training,” he says, “But all my athletes, and I’ve treated over 50 Olympians,” he said, “set a personal best or season best within a week of doing it.”

I like the idea of nothing but Medical Food shakes and organic vegetables, non starchy for that matter, low glycemic index, ’cause you don’t want to spike blood sugar, and get people to get the right fiber, the right water, the right elimination to help their body through. As I tell people, it’s been published now for well over 20 years in the clinical literature, symptoms of chronic poisoning include fatigue, sleep disturbance, intestinal distress, allergy symptoms, headaches, confusion and anxiety, and guess what? Those things can actually temporarily get worse on a detox, and so people will call me and say, “This ain’t working. I’m sick as a dog.” I say, “No, it’s working. The reason you’re sick as a dog is it is working.”

So we can either, one, tough it out, which believe it or not, a lot of people decide to, ’cause after a few days, this too shall pass; we can buffer it with other nutrients, things that support glutathione or bowel function or kidney function, or they can slow down the process. Stop, slow down, support it, or tough it out.

Dr. Weitz:                            Yeah, a lot of people talk about glutathione, NAC, lipoic acid are really important nutrients for facilitating detoxification. Do you use glutathione in your practice?

Dr. Rakowski:                     Yes, and no. Not to a high level, but certainly I’m going to support it in every different way. It’s a tripeptide, glutamine, glycine and cysteine and so for most people, cysteine, which is a sulfur containing amino acid, is a rate-limiting step, but cysteine, most of it’s derived from something called methionine, I don’t know if we want to get too deep about chemistry, but that requires B vitamins, activated B vitamins and more Bs then to actually help the body convert that all the way down to glutathione.

Another factor is in that pathway, the body can deplete a lot of its cysteine in making something in the body called metallothionein proteins, which by the way is another detox protein, but it clears out heavy metals. You mentioned the lead in the drinking water, but the data shows the modern skeleton contains 500 to 1,000 times the lead of preindustrial humans, so heavy metal detox, guess what, that’s a different thing altogether, and there’s different nutrients that drive that process, as well.

Dr. Weitz:                            Yeah. We do a NutraEval on a lot of our new patients and that includes a heavy metal panel and we see a lot of mercury, a lot of people with elevated metals, very common.

Dr. Rakowski:                     And certainly that’s gonna deplete glutathione along the same path. So pretty tough game. A good comprehensive doc like yourself that knows what to look for and knows how to guide people through. Guess what, people are struggling and they need what they offer, what we offer.

Dr. Weitz:                            Yeah, a lot of people are shocked to see how high their mercury levels are, and a lot of it’s coming from fish.

Dr. Rakowski:                     Yeah, I’ve been in clinical practice 26 years and there was a clinic, basically in the same center as mine, called the Detoxification Centers of Texas, and they would actually infuse substances that were known to pull out heavy metal and capture a 24 hour urine, and they did this for the purpose of documentation, really to get insurance reimbursement. But I asked the clinic director, I said, “Look, how long you been doing this?” And she said, “Well, 12 years.” I said, how many negatives have you seen? In other words, nobody had an excess of heavy metals.” She said, “Bob, zero. Zero. It’s just ubiquitous. We’ve got these metals in our system.” Now, are they harmful to everybody? Probably not. We have different sensitivities, but are they harmful to all people? Yeah, and they don’t know it. So it’s a good thing to find out.

Dr. Weitz:                            Yeah, a lot of times, they have unusual reactions. Some people will have elevated LDL cholesterol levels, some people will have … It’ll affect their digestion. Some people, it’ll affect their concentration and memory and so it really can affect your metabolism a lot of different ways and you don’t know it unless you really just test for it.

Dr. Rakowski:                     Yeah. I think it may be the best kept secret in all of medicine that we can pull these poisons out of the system and like we said, fatigue, sleep disturbance, intestinal distress, allergy symptoms, headaches, confusion, anxiety and other things can all get better with a good detox.

Dr. Weitz:                            So, after doing a one week detox, what can people do on an ongoing basis to continue to detox and so that they’re continuing to remove metals or remove toxins and reduce their burden as they go through their life?

Dr. Rakowski:                     If you don’t mind, I’m gonna answer that just a slightly different way. So I recommend the intense week twice a year, but I’ll often be asked at my seminars, “How long should we detox?” And the way I teach that is by saying, “Let’s do a little experiment. I’ll set my watch and let’s all stop detoxing right now.” Which, by the way, the basic element of detox is to exhale. So the room is dead in five minutes.  We know that we constantly need to support that, and we know with every breath, believe it or not, we’re taking in these toxins, and as our body makes energy, we create toxins, so we need ongoing daily support, and that’s why I said I’m gonna consume these functional food shakes myself, at least 300 days a year and many of those 300 days, I’m gonna take two or more per day. And so, I actually lectured in Orlando, Florida when Barry Sears, who wrote the book The Zone, released it. And he had the USDA food pyramid, which now they have their plate, which is not much better, but they had their pyramid back then with 9 to 11 servings of processed carbohydrates at the base of the pyramid.

And Barry Sears said this, he said, “If ever there was a terrorist like plot designed to take the health of the world down, this would be it.” But so I created a life pyramid where I have love at the base and purpose and discipline, but I also have a food pyramid. And so the base is gonna be food, organic food, not too much, mostly plants. The next one is gonna be super foods, so there’s tons of those. My favorite is ganoderma, which is also known as reishi. There’s aloe and there’s spirulina and there’s goji berries and acai berries.  Lots of berries are actually super foods in and of themselves. And then we move up and I think everybody should take a nice bioabsorbable multivitamin and then they should take omega 3s and probiotics and now we know instead of D, there should be a D3 K2 combo, and those are actually if you’re counting seven. So I like sevens, the magnificent seven. And the seven things we need in our nutrition pyramid.  Accompany that with seven good nights of sleep a week and at least seven good bowel movements, and we’re gonna be in pretty good shape.

Dr. Weitz:                            There you go. As far as sleep goes, there are many in our society that don’t get adequate amounts of sleep.

Dr. Rakowski:                     Too many, too many, and so there’s a lot of calming adaptogens for the central nervous system. Green tea has an amino acid in it called theanine, and theanine’s very calming, so it buffers the caffeine in green tea. I like straight theanine, which is a known, if your listeners are familiar with the term GABA facilitator, very, very calming.

Melatonin, we now know that melatonin is, believe it or not, even in single cell organisms, it’s a mitochondrial specific antioxidant, enhances human energy production. The gut makes 400 times the amount of melatonin as the brain and melatonin puts the brakes on our stress drive in our body. So since the gut has so much, it likely doesn’t cross the blood brain barrier, but by calming our stress response, that’s often calming enough to put people to sleep. But people need a routine, they need a dark, quiet, calm, cool, peaceful room without wifi, and whatever their routine is, wind down an hour before bed, don’t get hyped up watching sports, ’cause that’ll keep you up for hours, or something that rivals you in any other way.

Have a wind down routine on your body, honor that routine, and figure out what you need for your sweet spot. The best of the best need 8.6 hours a night. Sleep is a little bit like a shoe size, but our military actually did a study and they found out if they gave soldiers less than six hours of sleep for six straight days, they actually functioned as if they were legally drunk.

Dr. Weitz:                            Wow.

Dr. Rakowski:                     So imagine those guys walking around with high powered weapons. Sleep deprivation is the norm. So, a good sleep routine and enough hours to have you wake up refreshed.

Dr. Weitz:                            How much melatonin do you like?

Dr. Rakowski:                     Well, now you’re asking me. I’m a big melatonin guy, so I actually like to use 50 milligrams of time release … 10 milligrams time released capsules, I take five at bedtime, but the NIH did a study, by the way I’m-healthy, right-

Dr. Weitz:                            That’s a very high dosage, 50 milligrams.

Dr. Rakowski:                     It is. They did 50 milligrams at bedtime, not even timed release, just straight up 50 milligrams with a dose of D3 and they found out that it prolongs survivability and prevented lean tissue breakdown of non-operable cancer patients. And remember, it’s not gonna cross the blood brain barrier, and it’s pretty fascinating. I do it myself. I can’t say I do it all the time, and there’s plenty of times when I’m on the road, “Oh, I forgot my melatonin.”  Guess what?  I still sleep.  But someone posted something on the internet how everybody and their brother these days wants to be a bio hacker, doing different things to try to increase longevity, but it’s a mitochondrial specific antioxidant that’s present in single cell organisms that it buffers the stress response and now I’ve been doing that for about a decade, since I saw that study in the NIH.   I can tell you that in the last decade, my biologic aging has been very slight. So, I think it’s a complete program, but that’s one factor there.

Dr. Weitz:                            Wow. Very interesting. Yeah, we usually use 20 milligrams for patients with cancer. Some of the studies seem to indicate, and I’ve had some patients who get nightmares when they go up to 20 milligrams.

Dr. Rakowski:                     There is another further downstream metabolite of melatonin, which is profoundly hallucinogenic and what’s fascinating about that is there’s a plant in South American, and shaman they use something called Ayahuasca-

Dr. Weitz:                            Oh, yeah.

Dr. Rakowski:                     … it’s a downstream metabolite of melatonin-

Dr. Weitz:                            Interesting.

Dr. Rakowski:                     Yeah, the shaman actually believe that it increases a higher level of consciousness, and for many it does, but for others, it can cause these profound responses. So I’ll share with you, I was teaching a seminar like I do, many, many times a year, literally taught over 10,000 hours to help professionals around the globe, and I had a 30-year pharmacist in one of my classes that said, “You know what, I love melatonin, I’ve been experimenting with it for a long time,” and here’s what they said, they said they believe the people that have the really most profound responses, in their experience, actually need more and it’s something that they can get through over time.  Now, I’m of the mindset that there’s gotta be, possibly, a pathway that needs to be supported in another way, nutritionally, to make it happen. And so, that might be activated B vitamins, it might be some of the minerals, and we know our general population, well, here’s the stats, 99% are deficient of one or more of those things. So when we do a comprehensive program, I think we can help a lot of people with that.

Dr. Weitz:                            Cool. Cool. Very interesting. Yeah, they use Ayahuasca for patients with PTSD. Apparently, it’s one of the more effective treatments for that.

Dr. Rakowski:                     Since I’m in a community of such naturally minded people with a lot of means, I literally know dozens, including myself, that have gone with shamans with organic product and realized, “There’s something to this plant.” But part of what I like to say is, “Don’t try this at home. Let’s go with people that have dedicated their lifetime to studying the plants and the rain forest and helping people to understand their body and work through the process.”

Dr. Weitz:                            What about using high dose melatonin with patients with PTSD? That would be a kind of interesting study.

Dr. Rakowski:                     I haven’t seen that study. I’m a big fan of thiamine as the GABA facilitator. I don’t know that I want to take the chance on those folks and nightmares, but if we know they handle it right, that might be a titrated up dose.  God bless those people. They’ve had more challenges than I wish on any person.

Dr. Weitz:                            Yeah. Great. So, thanks for providing us some great information, Dr. Rakowski. This has been a fun podcast. For listeners who want to get a hold of you, what’s the best way for them to contact you?

Dr. Rakowski:                     I’ve got a website called thedoctorbob.com, and that’s a good way. There’s a “contact us” tab, and that’s a great way to do it. if you did contact me because of this podcast, let me know, and I certainly want to send our friend Dr. Ben a thank-you note, and one of my favorite things is to share information and I appreciate the opportunity to do it with you and your incredible group.

Dr. Weitz:                            That’s great, and you’re available for consultations via phone or Skype?

Dr. Rakowski:                     All the above, yeah. We kind of shifted now away from Skype to Zoom-

Dr. Weitz:                            Zoom, okay.

Dr. Rakowski:                     … for whatever reason, but it’s probably been a couple years since I’ve done Skype, but I’ve Zoomed halfway around the world and most of the things I’m going to recommend, I do have connections halfway around the world, ’cause I’ve taught halfway around the world, and we can make recommendations and connect you with a great source for nutrition, poor nutrition, to help you with whatever you’re challenged with.

Dr. Weitz:                            That’s great. Thank you so much, Bob.

Dr. Rakowski:                     You’re welcome.

 

 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Optimum Hydration with Dr. Dana Cohen: Rational Wellness Podcast 68
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Dr. Dana Cohen explains how to optimize hydration by eating foods with water in the gel state with Dr. Ben Weitz. 

[If you enjoy this podcast, please give us a rating and review on Itunes, so more people will find The Rational Wellness Podcast] 

 

Podcast Highlights

2:48  Dr. Cohen explains that being in a state of sub-clinical, low grade dehydration can lead to fatigue, brain fog, dry skin, constipation, but them, even more important things, it puts you at risk for certain cancers like bladder cancer and colon cancer. It also can put you at risk for Type II diabetes and Alzheimer’s disease.

5:25  Dr. Cohen explains that we know that water exists as liquid, ice, and vapor. We now know that there’s another phase of water called gel water or structured water, which is the type of water that’s in our cells and this exists in plants, in fruits and vegetables.  So by eating more fruits and vegetables we can get better hydrated than by just drinking water, which she talks about in her new book, Quench: Beat Fatigue, Drop Weight, and Heal Your Body Through the New Science of Optimum Hydration. Now we have science to back up why we should have a green smoothie and eat more hydrated foods.

7:15  Dr. Cohen recommends drinking 16 oz of water with some sea salt and a squeeze of lemon to start your day and then drink 8 oz of water before every meal. They’ll feel better and they’ll also lose a few pounds.

9:35  Dr. Cohen said that common table salt is just sodium and is dehydrating, while natural sea salt or Himalyan pink salt have other minerals besides sodium, so they are hydrating for the body. 

11:48  Dr. Cohen wrote that we should eat fruits and vegetables that are in season because research shows that the microbiome changes seasonally.

13:53  Dana noted that chia seeds are one of the more hydrating foods and she highlighted the gel that forms when you wet them.

16:19  Lychee fruit is great for skin, has antioxidants, helps with blood sugar and protects against sun damage and is a very hydrating food. Since it has a short growing season, she will often use a nutritional supplement, Oligonol, and she will open two capsules into a smoothie. 

18:35  Prickly pear from cactus is another very hydrating plant food.

19:33  Aloe vera has water in the gel state, so it is also very hydrating.

 

                            



Dr. Dana Cohen is a nationally renowned internal and integrative medicine specialist, based in New York City. Her new book is Quench: Beat Fatigue, Drop Weight, and Heal Your Body Through the New Science of Optimum Hydration. Her website is www.drdanacohen.com and her coathor’s website if HydrationFoundation.org.

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.


 

Podcast Transcripts

Dr. Weitz:            This is Dr. Ben Weitz with, The Rational Wellness Podcast, bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field.  Please subscribe to The Rational Wellness Podcast on iTunes and YouTube and sign up for my free eBook on my website by going to drweitz.com. Let’s get started on your road to better health.  Hello Rational Wellness Podcasters. Thank you so much for joining me again today and, for those of you who enjoy The Rational Wellness Podcast, please go to iTunes and give us a ratings and review.

So our topic for today is water and what is the best way to get hydrated. It’s often stated that Americans do not drink enough water, and many doctors believe that as many as 75% of Americans are under-hydrated. I personally test all of my patients with bioimpedance analysis for their body composition, and we find very few who are optimally hydrated.  I often encourage my patients to drink more water and so do many functional medicine doctors, nutritionists and health coaches. Its typically recommended that patients drink eight to 12 glasses of water per day or at least half of their body weight in ounces of water. However, new research has discovered that water, which has been thought to exist in one of three states, liquid, gas or, solid actually exists in a fourth gel like state that has the potential to hydrate the body more effectively and efficiently than just plain water.

This new state of structured water is also more organized, making it more effective for healing at the cellular level. Dr. Dana Cohen is our special guest today and, she’s a nationally renowned internal and integrative medicine specialist based in New York City. She trained under the late Dr. Robert Atkins and also under Donald Ronald Hoffman, two of the pioneers of functional medicine.

Dr. Cohen says that new research shows that hydration may not be as simple as drinking more water, it’s a premise of her new book, Quench: Beat Fatigue, Drop Weight, and Heal Your Body Through the New Science of Optimum Hydration. And in fact, she says, drinking too much water can actually cause harm to your body by flushing out vital nutrients and electrolytes from your cells.  Dr. Cohen, thank you so much for taking time out of your schedule to join us today.

Dr. Cohen:          Thank you for having me.

Dr. Weitz:            So, how dangerous is it to be under-hydrated and what concerns can arise from not being properly hydrated?

Dr. Cohen:          Okay so, I want to clarify first that we’re not talking about overt dehydration where you’re in the hospital needing IV fluids and you have heatstroke, and those are, can be life threatening. We’re talking about this sort of sub-clinical, low grade dehydration which we give evidence that shows basic things, fatigue, brain fog, dry skin, constipation, but then, even more important things, it puts you at risk for certain cancers like bladder cancer or colon cancer. It also can put you at risk for Type II diabetes and even Alzheimer’s disease. So it is, I think, a very real problem.

Dr. Weitz:            How do you know if you’re under-hydrated?

Dr. Cohen:          So, okay, good question. Everybody, the first thing people think about is thirst. The truth is, thirst is not a great measure because we’ve learned to override our thirst or ignore our thirst so, some ways that you can know, once again, fatigue. We actually, I really believe that fatigue is your first sign of dehydration and instead of maybe going for some coffee or sugar in the afternoon, think about hydrating better when you get that slump.  So fatigue, brain fog. Other things that we can think about. So, we’re meant to urinate every two or three hours and, if you’re not doing that, you may be dehydrated. A good rule of thumb and at home test that we can do is, look at the color of your urine, we want it to be pale yellow. If it’s dark orange or darker, you’re dehydrated, with one caveat that us as integrative practitioners know, if you’re taking B vitamins, that rule doesn’t hold because it turns your urine bright yellow.

Dr. Weitz:            Yeah, my urine is very dark, I take so many supplements.

Dr. Cohen:          Yeah so, that’s not the best thing for you to do.  Another good at home thing is, you could pinch the top of your hand, the skin on the top of your hand, if it stays up there, if it tents up for longer than a millisecond, you’re dehydrated or, can be dehydrated.  So, that’s a little at home test you can do as well.

Dr. Weitz:            So, what’s the best way to get properly hydrated?

Dr. Cohen:          Great question.

Dr. Weitz:           We kind of teased that in the intro.

Dr. Cohen:          So, what we talk about well, lets just get right into it. Let’s talk about the new, the new discovery that we’re all, that you sort of alluded to earlier.  We know that water exists as liquid, ice and vapor. Now we know that there’s another phase of water and, this phase of water we call gel water or structured water in the book is, it’s different, it has different properties than regular bulk water.  What we’ve discovered is that this is the type of water that’s in our cells and also happens to be the type of water that’s in plants.  And so, by eating your water, by having more plants and vegetables and that can kind of thing, it’s a much more effective way of getting better hydrated.  So, that’s what we tell you.  A lot of it is instinctual but now we have real science to back up why we should have a smoothie every day and why we should eat our greens in concentrated forms and eat more hydrating foods.

Dr. Weitz:            Are there products on the market now, structured water? And, if they’re not, I’m sure there will be.

Dr. Cohen:          They do exist. There are machines that can structure your water. We don’t talk, I don’t know any of them, I don’t, what’s the word? Recommend any of them because I haven’t done the research on them, I don’t know about them. The book is for the masses, this is for every person how you can get this water by eating better, eating more fresh fruits and vegetables, eating your water and following some simple rules.  We lay out a very easy five day plan in the book where you just follow them. So, I’ll give you a couple of them right now. A first rule is, we want to wake up and front load your water so, 16 ounces of a big glass of water with a little bit of sea salt to get some good electrolytes in there and a squeeze of lemon, start your day that way, that’s one rule.

Another rule I can give you is, you want to drink eight ounces before every meal. So that’s a way of getting water in right before your meal and there’s some research behind that that it also can help lose a few pounds if you just do that and do nothing else.

Dr. Weitz:            Now, now, you know, I like to have some of my clients do that but I know a number of people in the nutritional world who feel that drinking water prior to your meal is going to dilute your enzymes.

Dr. Cohen:          Yeah, I’ve had no problems with it and I’ve been researching this book for three and a half years, I’ve been giving the program to patients and, in fact, their digestion is improving, they do lose a little bit of weight, their brain fog goes away, their fatigue, if you’re hydrating better.

Dr. Weitz:            It doesn’t matter if the water is cold or room water, does it matter if it’s carbonated?

Dr. Cohen:          It’s a good question, I don’t know, I really don’t know. I know in Chinese medicine there’s something to, depending on what type of whether you’re damp or a hot person, I don’t know, and there’s something to that. I’m not a Chinese medicine practitioner so I don’t know. I definitely think there’s something to it but, I honestly don’t know. As far as carbonation, I don’t have a problem with carbonation, I actually drink a lot of Pellegrino, a natural carbonated spring water but I think the jury is out on that one, I don’t think there’s evidence either way.

Dr. Weitz:            Yeah, even acupuncturists in my office, we kind of still having a battle. I’ll put ice on a patient and she’ll say, “No, don’t put ice, we have to use heat.”

Dr. Cohen:          I know and I think the truth is, whatever gets you to drink better, I think is important.

Dr. Weitz:            So I was reading your book, Quench, this morning while walking on the treadmill and drinking some water.

Dr. Cohen:          Love it. Excellent.

Dr. Weitz:            I want to ask a couple of questions that are a little bit off track and then we’ll get back to the foods is, you talked about how some foods like pizza have the wrong kind of salt that’s dehydrating while natural salt is hydrating. Can you explain that?

Dr. Cohen:          Yeah so, like the store bought table salt, I don’t think I should mention any names but, the one with the girl with the umbrella on it and the galoshes, I mean its sodium, it’s just sodium, there’s no minerals, there’s no other minerals in there.

Dr. Weitz:            Yeah, there is iodine in it. Sodium iodine.

Dr. Cohen:          Sodium is iodized salt, yes, yeah, if it’s iodized but, you can get sea salt iodized as well and that’s a whole conversation on its own and I do think almost everybody is deficient in iodine as well. Unfortunately, we don’t have great ways of measuring that but yes, the iodine is a separate issue.  But, the table salt is just sodium, real salt has an abundance of other minerals and electrolytes that we need that is and, there’s a lot of research behind it too that’s been shown, it’s not going to affect your blood pressure in a way that we at least thought salt was such a bad thing for us.  So that’s the difference.

Dr. Weitz:            Yeah so, in fact, you say that having sea salt and natural forms of salt like Himalayan Pink Salt actually helps with blood pressure.

Dr. Cohen:          Well, I think there’s something to that, I’m not sure if it actually helps with blood pressure but, I don’t think it harms.

Dr. Weitz:            Yeah.

Dr. Cohen:          You know so, I think and, there may be a select few that have very salt sensitive hypertension that they do need to worry about it so, its hard for me to say, I still want people to be careful, who have high blood pressure and even using real salt, you just need to monitor and look at it but, I don’t think it’s the foe that we’ve made it to be at all.

Dr. Weitz:            Yeah, no, I read that book by James DiNicolantonio about salt (The Salt Fix) and it was really sort of a shock that, everything we thought about salt, kind of like, everything we thought about saturated fat isn’t quite true.

Dr. Cohen:          Right. Exactly.

Dr. Weitz:            One more thing that I was reading about in your book was, you talk about eating seasonally, eating fruits and vegetables that are in season and you also mention that our microbiome, which is the bacteria in our colon, actually changes according to the season and I thought that was really fascinating and I don’t think that’s information that people commonly talk about.

Dr. Cohen:          Yeah, we touch upon it lightly in the book and, we’ve looked at the research, I think his name is Julliard, John Julliard, I think his name is. There’s some very interesting research that how the microbiome does change seasonally and that’s one of the reasons that we should eat what’s available to us. I have a feeling that that’s probably the key of why eating seasonally is really good and important for us. And there’s some research to back that up as well.

Dr. Weitz:            Yeah, interesting.  So, can you tell us about why it’s so important to eat certain fruits and vegetables and seeds that can help to hydrate us?

Dr. Cohen:          Suer so, I would love to, I picked out four things today to specifically talk about so, they’re a little bit unusual but they’re sort of fun to talk about.

Dr. Weitz:            By the way, these are examples, right? And, most, my understanding from reading your book is, most fruits and vegetables and also nuts and seeds in general are very hydrating?

Dr. Cohen:          Exactly, exactly and we lay out many, many examples in the book. We have over 50 recipes. I love to just bring up the example of even iceberg lettuce. Iceberg lettuce, you know, we always thought has no nutritional value. As it turns out, it’s probably one of the most hydrating vegetables you can eat because it’s just loaded with that structured water and that alone makes it worth it’s weight in gold.  So iceberg lettuce, there’s a reason for. So, let’s talk about chia seeds first.

Dr. Weitz:            Okay.

Dr. Cohen:          Chia seeds …

Dr. Weitz:            And by the way, I wouldn’t normally think of dried seeds as being moisturizing.

Dr. Cohen:          Yes. So, if you’ve ever seen or made a recipe for chia pudding, you know that when you add liquid to chia it forms that gel, it makes a very gelatinous, a mucilaginous surrounding the seed so that is that gel water, it’s going to hold onto and absorb water better than regular water.   And, there’s actually this Mexican tribe of people, the Tarahumara tribe who, anthropologically would run 50 mile marathons on water and chia seeds. So chia has, they are really the star of the show, they are a super food, they’re loaded with Omega 3 fatty acids, they’re really good for endurance, they’re great for blood sugar and, I just think, I love to throw them in my smoothies, make chia pudding, throw them on your salads. They’re a very hydrating food.

Dr. Weitz:            Okay.

Dr. Cohen:          Second one I want to talk about, another sort of fun and unusual one …

Dr. Weitz:            Now, do you just eat the chia seeds raw or do you grind them up first?

Dr. Cohen:          I love to grind them because you’re creating more surface area when you grind them. I’ll do both but, I think grinding them, you’re probably getting more gel water because you’re creating more surface area. So I think ground chia seeds are a better way to do it.  In fact we tell a story in the book from my co-author. She is an anthropologist, her mother was in a nursing home with Alzheimer’s and she was suffering from dehydration, like literally overt dehydration and, her mother would never ask for more water or, you know, she was very proper and she decided to tell the nurses to put some chia in her water every morning and that cured the problem, she never had another UTI after that, urinary tract infection. So, yeah, chia seeds are really important and great for us and inexpensive. Anybody can find them everywhere, it’s a great thing to do and to start putting in your water.

So let’s talk about the second one, speaking of seasonal fruits and vegetables, I want to talk about Lychee (aka, litchi) fruit. Lychee, have you ever had a litchi? Do you know what it is?

Dr. Weitz:            Not really. I was at some wedding that had like every exotic fruit known to mankind and I’m sure I ate it but I don’t remember which one it was.

Dr. Cohen:          I think lychee, you’re going to start to hear about lychee’s like, I think it’s going to be the next super food.

Dr. Weitz:            Next super food?

Dr. Cohen:          Yeah.  They are delicious, they’re from South-East Asia in fact, you know, I love anthropological information, these ancient Chinese princesses used to have their servants get them litchi fruit to keep their skin youthful so, lychee is great for skin, youthful skin, it’s a very powerful antioxidant, it helps with blood sugar, it helps protect against UV radiation, ultraviolet radiation from sun damage, that kind of thing.  Couple of problems with litchi is, they, and by the way, they taste incredible, they’re delicious. I’ll often just sort of throw them in water and it’s a tiny little fruit, I actually have some here, I’m going to show you. Can you see that?

Dr. Weitz:            Okay.

Dr. Cohen:          So they look like little eyeballs, these are seeded, there’s a pit in the middle and, so when you pop open a litchi you can see the gel just sort of coming out very, very gel like. The one problem is, they’re seasonal so they’re hard to get, only short period of season we can get them and, they’re high in sugar.  So, what I’ll often do is recommend a supplement because I do recommend a lot of supplements. There’s a supplement called Oligonol, there’s over 30 human clinical trials, it’s made from lychee fruit. I’ll pop open the capsules in the winter and throw it in my smoothie, two capsules a day and that supplement has been shown to help with decreased belly fat, decreased brown spots from skin aging, really great supplement made from lychee.  And, other than that, a couple one or two lychee in a glass of water will help structure that water a little bit better than without it.

The third thing I want to talk about is, and you may have played a little bit more with this is, prickly pear which is a cactus fruit. I do have one here. I love prickly pear. Basically what I’ll do is I’ll cut off both ends, peel it off, it’s bright red. This is water infused with prickly pear. Can you see how red it is?

Dr. Weitz:            Okay, yeah.

Dr. Cohen:          Also, really delicious but, it does have seeds in it so you have to put it through a strainer before you do anything with it.  Prickly pear is great for blood sugar also, helps with cholesterol, what else is it good for? Known as a hangover remedy. So, if you’ve imbibed too much, have some prickly pear. Prickly pear and lime is a really wonderful water infuser. There’s jam’s and jellies you can make with that but, maybe a little too much sugar also.

And then last I want to talk about is, aloe. All these cactus fruits. Aloe, I grew up in South Florida, originally from Long Island but, we moved to South Florida when I was little and, we always had aloe plants outside. So, everybody knows if you get a burn, you go outside, cut an aloe leaf and put it on top of your burn, it really helps your skin. But taken internally, aloe can help with digestion, it can help with constipation, also maybe help with blood sugar so, basically just open an aloe leaf, take that gel inside of it, throw it in your smoothie, or just eat it. There’s aloe juice you can buy now, great for all of those things, for digestion, heart burn, constipation.  So a couple of fruits, sort of fun and unusual, easy, play around with them and, they’re ally delicious.

Dr. Weitz:            Sounds good, yeah. We use aloe a lot for all sorts of issues, it seems to be really good for the skin and it’s good for the gut as well so, we use some supplements that have aloe in it as one of the ingredients.

Dr. Cohen:          Yeah, the one thing I’d be a little careful about is too much, even natural aloe can lead to diarrhea so you just got to find your perfect sort of dose.

Dr. Weitz:            Yep, yep.  Great. So, how can listeners or viewers get hold of you and get a hold of your book? I’m assuming its available from Amazon, Barnes and Noble.

Dr. Cohen:          Everywhere books are sold. My website is, www. drdanacohen.com and my coauthors website, there’s a lot of information, it’s the hydrationfoundation.org. Tons of information up there about water and all the new research that’s coming out with new water.  And by the way, water is way more complicated than I ever thought before I embarked on this journey and every day there’s something new coming out about it so, yeah.

Dr. Weitz:            Yeah. Good, good, good and, I’m assuming you still see patients in your office and remote. Do you do consultations?

Dr. Cohen:          I don’t see people remotely unless, you have to see me one time in person because I still am an old timely doctor, I like to put my hands on patients but I do see people in New York City, my office is called completewellnessnyc.com.

Dr. Weitz:            Great. Thank you so much for joining us.

Dr. Cohen:          Thank you Ben.

 

Johnson and Johnson has recently announced that they have pulled the plug on another drug–atabecestat–designed to block amyloid plaque buildup because it didn’t work and had significant side effects. This drug was designed to block Beta-secretase 1 (BACE1), which is an enzyme involved in beta-amyloid production.  Drugs to block this enzyme (BACE inhibitors) in theory would prevent the buildup of beta-amyloid and (per the Amyloid hypothesis) may help slow or stop Alzheimers disease. 

One of the problems with this hypothesis is that the laying down of beta-amyloid protein is not the real causative factor in Alzheimer’s disease. The body lays down the beta-amyloid protein in response to heavy metals or pathogens–viruses or bacteria–that create inflammation in the brain that the body is attempting to protect against. The amyloid protein is a protective coating for the brain.

A Functional Medicine approach, such as the one outlined out by Dr. Dale Bredesen in his paper, Reversal of cognitive decline in Alzheimer’s disease(2), and his book, The End of Alzheimer’s(3), is liable to be more effective because it attempts to modify the underlying causes of Alzheimer’s.  The medical approach that targets one particular pathway has not proven effective after many failed attempts at drug development. The Functional Medicine approach is more complicated, looking at multiple pathways, mechanisms, and triggers, but this is needed for a complex condition. Dr. Weitz has studied Dr. Bredesen’s ReCODE approach and can provide a Functional Medicine approach to investigate some of the many possible underlying factors that can result in dementia and the pathological processes that result in autoimmune conditions like Alzheimer’s or Parkinson’s disease.

 
We have known for a while that vitamin D is potentially protective against various chronic diseases, like cancer.  And we know that raising your vitamin D levels above 20 or 30 ng/mL, which most labs say is normal, is beneficial.  We also been told to be careful not to take too much vitamin D because it can be toxic at high levels.  But what is the optimal range for your best overall health?  Is it better to be on the higher end or the lower end?   
 
It has been common for Functional Medicine practitioners to recommend an optimal level of vitamin D of 40-60 or 50-70 ng/mL or even more for patients with cancer, while conventional MDs often consider vitamin D levels of 20-30 ng/mL to be sufficient.  This is partially because for years we were warned not to take too much of the oil soluble vitamins, like vitamin A and vitamin D, since unlike the water soluble vitamins, the oil soluble ones can build up in your body and become toxic at a certain levels.  However, in recent years we have learned that the upper limits  of vitamin D are much higher than previously thought.  And while some Functional Medicine doctors have been recommending fairly high levels, I have not been confident that there was enough rigorous data to support making an aggressive recommendation for the higher ranges of vitamin D, such as 50-70 ng/mL.       
 
This new review paper found that women who had vitamin D levels above 60 ng/mL had the most protection against breast cancer.  In fact women who had vit D levels above 60 had a 82% lower risk of breast cancer than women who had vitamin D levels below 20 ng/mL.  There was a clear linear relationship between higher levels of vitamin D and lower rates of breast cancer, with more protection at progressively higher levels of vitamin D.  
 
The authors of this paper provide the following explanation for how vitamin D reduces breast cancer risk: “The biologically active form of vitamin D, 1,25(OH)2D3, binds to the vitamin D receptor (VDR) in normal breast epithelium and this complex regulates the cell cycle, promotes differentiation, increases cell-to-cell adhesion, protects cells from DNA damage, regulates cytokines, activates immune cells, and suppresses inflammation, all of which may act to reduce malignant transformations.  In breast cancer cells, this complex also activates apoptosis and other mechanisms to suppress tumor growth”.  

 

Dr. Ben Weitz is a Sports Chiropractor and Functional Medicine practitioner and he is available for both chiropractic care and for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss by calling his Santa Monica office 310-395-3111 or going to www.drweitz.com. 

Weitz Sports Chiropractic and Nutrition
Weitz Sports Chiropractic and Nutrition
Inflammatory Bowel Disease with Dr. Sam Rahbar: Rational Wellness Podcast 60
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Dr. Sam Rahbar talks about treating Inflammatory Bowel Disease patients with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Itunes, so more people will find The Rational Wellness Podcast] 

 

Podcast Highlights

0:50  I introduced the topic–Inflammatory Bowel Disease–and reviewed some of the basics of Crohn’s and Ulcerative colitis, the two most common conditions in this category.

4:12  I asked Dr. Rahbar what would make him suspect Inflammatory Bowel Disease (IBD) in a patient?  Answer: 1. GI symptoms for more than 2 wks,   2. abdominal pain,  3. diarrhea,  4. bloody stools,  5. secondary symptoms could include uveitis, skin problems, joint pain, back pain,  6. elevated inflammatory markers on lab tests, including an elevated HsCRP, SED rate, or an elevated white count. 

5:34   Examination should include colonoscopy plus endoscopy and/or imaging or a combination of the above.  Dr. Rahbar explained that a colonoscopy should include the physician entering the terminal ileum to look for evidence of inflammation. Some cases of Crohn’s may be limited to the small intestine, requiring capture endscopy or additional imaging studies, such as MRI enterography or a CT scan.

6:33  While symptoms of IBD are similar to IBS, IBD patients have physical damage to the lining of their intestines, whereas with IBS there is no physical damage.

11:28  I asked Dr. Rahbar what type of diet is best for patients with Inflammatory Bowel Disease? He said that he likes the Specific Carbohydrate Diet, though he will individualize the diet for each person. He has used SCD, Low FODMAP, and gluten free. The Specific Carbohydrate Diet, which can be helpful since there are a variety of carbohydrates that tend to promote inflammation in the gut, but it also tends to deplete the patient of vitamins and probiotics, which can negatively impact the microbiome, so they should be augmented with additional supplements to maintain balance in the body. Some of his patients have done well with a ketogenic diet, though he doesn’t like them to eat a lot of meat, which can also be inflammatory. Dr. Rahbar likes to do food sensitivity testing to see which foods to avoid for each to individualize the diet. He also looks for infections and fungal overgrowth and may treat them at the same time. But if you limit carbs too much, the patient may become depressed. 

16:50  The Elemental Diet can be helpful for a few weeks, sometimes for patients who haven’t responded to other approaches.

18:08  Check for infections such as SIBO or yeast overgrowth and clearing these out with with antimicrobials or antifungal herbs can help. 

18:40  I asked Dr/ Rahbar if he finds any nutritional supplements to be of benefit?  He said that if he feels the patients are not breaking down their proteins, he may add amino acids. He often uses oral immunoglobulins, which can help with surface healing. He has used a peptide PBC 157, which is very helpful, and is administered orally. He frequently uses zinc carnosine, omega three fatty acids, vitamin A, vitamin D, multivitamins, and anything that will improve surface healing of the gut lining.  He may use micronutrient testing to see which nutrients are most needed.  Curcumin, esp. liposomal form, at 3-5 gm per day can be helpful in reducing the inflammation. 

26:23  I asked Dr. Rahbar if he has ever tried helminth therapy–the use of parasitic worms therapeutically?  He is not yet comfortable with this therapy and would like to see more research on it. He is worried that in some of these immuno-compromised patients that the worms may take off and overgrow. 

27:43  I also asked him about Fecal Microbial Transplant (FMT) and he said that the research data is there and strong, but that with patients with Crohn’s, in order to get them into the terminal ileum, they will need to be ingested orally and not just implanted rectally. While one FMT may be helpful for C-diffocele infection, for Crohn’s it will probably have to be an ongoing set of FMTs to be effective. 

32:01  Stress is a modifier of the inflammatory response and weakens the immune system, resulting in both the immune system attacking the body’s own tissues but being less able to fight off infections.  The immune system ends up being dysregulated. Dr. Rahbar cited an article from the CDC that noted that IBD patients tend not to get enough exercise or enough sleep. Here is a reference on IBD and sleep: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995194/  Dr. Rahbar mentioned that exposure to mold, heavy metals, and tick borne illness can all play a role in inflammation and immune dysregulation.  Dr. Rahbar explained that some patients are harboring low grade, stealth infections. This is different than our classic understanding of infections and violates Koch’s postulate that one bug causes one illness. What we see in such cases are a variety of low level infections that could be bacterial, viral, or fungal and they work together in the background to keep the host busy and causes the immune system to be dysregulated and may result in various mild symptoms like allergies, skin problem, rashes, hives, itching, irritation, problems with sleep, joint problems, and energy issues. Essentially, such stealth infections can be triggers for autoimmune diseases.

 

 



Dr. Sam Rahbar is an Integrative Gastroenterologist in Century City combining conventional gastroenterology, performing colonoscopies, endoscopies, and Heidelberg pH testing, but incorporating anti-aging and Functional Medicine into his unique treatment approach. He can be contacted thru his website http://www.laintegrativegi.com/ or by calling his office 310.289.8000.  

Dr. Ben Weitz is available for nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also specializing in Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure and also weight loss, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.


 

Podcast Transcripts

Dr. Weitz:            This is Dr. Dr. Ben Weitz with the Rational Wellness podcast bringing you the cutting edge information on health and nutrition from the latest scientific research and by interviewing the top experts in the field. Please subscribe to the Rational Wellness podcast on iTunes and YouTube and sign up for my free ebook on my website by going to DrWeitz.com. Let’s get started on your road to better health.

Hello, Rational Wellness podcasters. Thank you so much for joining me again today. For those of you who enjoy the Rational Wellness podcast, please give us a ratings or review on iTunes so more people can find Rational Wellness podcast.

Our topic for today is Inflammatory Bowel Disorders. This is a very important topic. This is a very serious set of gastrointestinal conditions and if it’s not treated properly, this is a set of conditions that can sometimes require extreme surgery. People can even die from this set of conditions. So this is a very important topic to cover, and we’re going to be focused on trying to understand it from a Functional Medicine perspective, as we usually do.

So within the inflammatory bowel disorder topic, we have Crohn’s and Ulcerative colitis, which are the two most common conditions in that category. There’s a few less common inflammatory bowel conditions, including microscopic colitis. Inflammatory bowel disease or disorder is characterized by chronic inflammation of the gastrointestinal tract that means the lining from the esophagus all the way down to the colon and it leads to damage to the mucosal lining of this digestive tract.

Crohn’s disease can effect any part of the GI tract including the mouth, the esophagus, the stomach, and the anus. But most often if that’s the portion of the small intestine closest to the large intestine and there tend to be patchy areas of damage and this damage may reach through multiple layers of the intestinal wall.

Ulcerative colitis, in contrast, occurs only in the large intestine, the colon, and the rectum. Damaged areas typically are continuous and this usually starts at the rectum and spreads into the colon. It’s usually present in only the inner most lining of the colon.

Symptoms of inflammatory bowel disorders include persistent diarrhea, abdominal pain and cramping, bloody stools, weight loss, fatigue, among others. Anemia and other nutritional deficiencies are common with this disorder. The main stays of conventional medical treatment for inflammatory bowel disorders include immunosuppressant drugs including the newer biological drugs like Humira and Remicade, and surgical resection in severe cases. That’s where they’re actually removing part of the intestines or the colon. Some experimental treatments include fecal microbiol transplant, helminth or worm therapy, and cannabis.

I’m so happy to have an interview today with Dr. Farshid Sam Rahbar, Integrative Gastroenterologist in Century City. Dr. Rahbar is one of the smartest guys around and he performs endoscopy and colonoscopy like traditional gastrointestinal doctors, but he also incorporates anti-aging and Functional Medicine for a integrative, holistic approach to digestive care.

Dr. Weitz:            Dr. Rahbar, thank you so much for joining me today.

Dr. Rahbar:         Thank you. Thank you for this invitation and greetings to your audience.

Dr. Weitz:            Great. So when you get a patient, what would make you suspect that they might have an inflammatory bowel disorder?

Dr. Rahbar:         First of all, if the duration of symptoms have gone for more than two weeks, one has to be suspicious. The main symptoms are abdominal pain, diarrhea and blood in the stool. Obviously there could be other symptoms, but then there could be a second category of symptoms called non-digestive symptoms. Sometimes an eye related issue such as uveitis or a skin problem or joints or low back pain. Something else may be the primary manifestation, depending upon the genetic disposition of the individual. Occasionally we’re just dealing with some abnormal labs or something that suggests there are markers are inflammation or immune dysregulation and we would like to look and see if the patient’s suffering from an inflammatory bowel disease.

Dr. Weitz:            What would be some of those markers on labs that you might see?

Dr. Rahbar:         The common one is usually a C-reactive protein or a highly C-reactive protein. It may be an elevated white cell count or a SED rate. I mean, it could be common ones that we use to look for evidence of inflammation internally.

Dr. Weitz:            Okay. Great. So then how would you work that patient up if you suspect them of having potentially an inflammatory bowel disorder?

Dr. Rahbar:         Obviously at one point the patient would require anatomical assessment either in the form of an endoscopy and colonoscopy or imaging or a combination of these. If one does a colonoscopy, particularly in corelation to Crohn’s disease, then the physician tries to intubate or enter the very end of the small bowel called term terminal ileum to see if there’s any evidence of inflammation there. However, with Crohn’s in some rare cases the scenario of inflammation may be limited to the small bowel. In those cases, additional imaging and studies, such as a capture endoscopy or MRI enterography, or a CT scan with an imaging emphasis on the small bowel maybe necessary.

Dr. Weitz:            Some of the symptoms of inflammatory bowel disorders are similar to some functional bowel conditions like IBS. But the big difference is there’s actually physical damage to the intestinal tract in inflammatory bowel disorder and not in irritable bowel syndrome.

Dr. Rahbar:         Exactly. I mean, generally there’s anatomical changes and pathology and that suggests that there is an inflammatory bowel disease going on as opposed to irritable bowel syndrome.

Dr. Weitz:            So how do you apply a functional medicine approach to such patients?

Dr. Rahbar:         Right. There are few things to review here. First of all, when we talk about a functional medicine approach, it really refers to the mindset of the physician who’s handling the clinical picture. We like to believe that a functional medicine model will entail a scenario that the mindset of the physician involves the whole body approach. One may want to look at evidence of a nutritional status, micronutrient deficiencies, ability of the individual to detoxify, the relationship with the environment. Do they live close to a farm? Do they live in a mobile area where they might have been exposed to mycotoxins, or perhaps some suboptimal eating habits, fast eating too much, too late, high carbohydrates or eating barbecue and charred type of foods, which all increase the oxidative stress burden to the body. There’s also mind and body connection that effects the stress, which is tremendously important. At last, but not least, the integrity of the intestine itself, particularly small bowel, which had this in our practice and it’s an area of emphasis because we look for and we try to treat for a condition called increased intestinal permeability or what they call the so called leaky gut type problem. The idea would be if one can work on that model, can you reduce the overall inflammatory process in the person and help reduce their symptoms.

Now, having said that, I want to emphasize one thing that in our practice we still are integrative and we look at the spectrum of the illness. I have patients who have mild disease or moderate disease or more severe. I had one patient one day come in with abdominal pain and fever, had significant tenderness in the abdomen and he said, “Can you do a holistic approach for me?” The answer is, “No, you’re going to go to the hospital. They have to do antibiotics and steroids to calm down the severity of the problem.” When we’re running into the zone of the mild to moderate activity, we can rely on those alternative and integrative approaches to control the problem as opposed to relying, for example, on biological drugs and so forth.

Dr. Weitz:            Right. I think the important point for everybody to consider is that when we talk about the advantages of Functional Medicine in treating certain conditions, we’re not promoting Functional Medicine as an alternative to traditional medicine. Traditional medicine has great benefits, especially when somebody has an acute condition. You talk about the patient who’s having an acute attack of an inflammatory bowel disorder with fever, that’s when Western traditional medicine is really at it’s best. The problem is is that when you try to apply that acute care using these steroids and these other medications that can be very helpful in these acute situations and have patients continue taking them for months and years on end, when you have all these horrible side effects.

So I think it’s great that there’s somebody like you out there who can integrate both the acute model of traditional care and then maybe that patient who’s suffering from an acute aspect level of inflammatory bowel but maybe after he gets calmed down, then you can start looking at a Functional Medicine approach, try to find some of the triggers for the inflammation, and give him an alternative to simply being on these very harsh drugs the rest of their lives.

Dr. Rahbar:         Exactly.

Dr. Weitz:            So what type of dietary approaches do you find can be helpful in inflammatory bowel disorders?

Dr. Rahbar:         Obviously one model of diet would not fit all. Like anything else, the dietary changes may have their own benefits or drawbacks and one has to be careful with that. I do believe in similar traditional experience of a lot of our patients using a Specific Carbohydrate Diet without to this … At some point and time bring down the inflammatory process. It appears that the inflammation tends to get aggravated by a variety of carbohydrates. If you use carbs that are extremely simple for digestive process it’ll have less impact on the inflammatory process. However, if one, for example, stays on a specific carbohydrate diet which was defined some years ago. One on the other hand may get depleted of vitamins and prebiotics and other things that maybe necessary to keep the microbiome in good shape. So we may have to either augment with additional supplements or foods to be able to keep the balance going, if you will.

Dr. Weitz:            There seems to be a wide range of different dietary approaches. There’s one hospital that recommends a low fiber diet and they have the patient eating white bread and white rice. The Specific Carbohydrate Diet that absolutely recommends avoiding all grains. So how do we figure out what type of dietary approach makes the most sense and for any individual patient?

Dr. Rahbar:         There may not be an exact formula to follow, and I think each patient might have to individualize that. Sometimes go through a little bit of a trial and see what happens. I also have patients who have used a ketogenic diet. Again, the component of that would involve significant limitation of carbohydrates. On the other hand, I don’t like the idea of eating a lot of meat, particularly highly cooked or barbecued or processed foods, such as bacon and so forth and diary products because on the other hand, these by themselves may be inflammatory.

We also look at a variety of food sensitivity models using different labs. I know some of these may be considered experimental my insurance companies, but that’s different than our experience. I think a lot of patients have benefited from following some of the guidelines. So I would say you will have to customize it.  I mean, I would probably do a food sensitivity test and also a food allergy test to see if anything shows up. Maybe I should avoid or limit some of those. Then overall give a pattern of carbohydrate reduction without maybe going to the extremes, if you will. It doesn’t have to have a name. It’s more so the principle that needs to be followed.

We’re also search for infections. For example, if yeast is a problem, then again the sugary stuff coming into the picture and some of the newer research suggests that fungal elements may actually have a growth in the exacerbation of these inflammatory problems. With some of patients we have used anti-fungal herbs or medications to control that. So I wish I could give you a quicker answer with different names, but all of these Low FODMAP, SCD, there is gluten free. All of these we have at one point or another used for our patients.

Dr. Weitz:            What would you say are the most common carbohydrates you’re typically recommending that people avoid?

Dr. Rahbar:         I mean, if you look at the grains and the wheat, particularly in U.S., they may have high lectin levels. A lot of people show reactivity to those. Many of our patients have already tried those things with some benefit. I have to say by time they get to me, people are already sugar free, soda free, gluten free. It’s not like I have to walk them many times through it. But I think if the grains would be a target for me, then perhaps some refined sugars and also … I mean, most of us don’t eat bad food, but if somebody drinks a lot of carbonated beverages, that may add to the inflammatory process, particularly because of the high fructose corn syrup and so forth. So I mean, it goes back again to limiting some of the carbs. I may even limit fruits. Although some carbohydrates are needed to maintain physiology and maintain serotonin levels and the patient may otherwise become depressed. 

Dr. Weitz:            Have you used the Elemental diet in cases where patients are really inflamed?

Dr. Rahbar:         Yes. Absolutely. We have used the Elemental diet, which I think is a great …

Dr. Weitz:            Can you explain what the Elemental diet is?

Dr. Rahbar:         Elemental diet is basically the type of diet that all the nutrients that the body needs, the have been turned down to the basic molecules. The body basically has to do nothing. They’re ready for absorption. As long as you expose them to the lining, it can get absorbed. The oil part is usually MCT oils, which these are smaller molecules than the big oil that we eat in the food. The sugar is dextrose, which is a single molecule like glucose, and the protein is basically amino acids, which basically does not have to be broken down. There are scenarios that this could be really helpful. For example, when we had a patient who did not respond to the treatment and we found out the patient had SIBO. I put the patient for two to three weeks on the elemental diet, without any medication. The SIBO was resolved, and the inflammation went into remission. Basically it worked.

Dr. Weitz:            Yeah. I personally have found the inflammatory bowel disorder patients that I’d seen, a lot of them do seem to have some overlying infection with either SIBO or yeast or something else. A lot of times I have found using herbal antimicrobials when we cleared that out, a lot of times that will help the inflammation to go down.

Dr. Rahbar:         Yes. That has been my experience with that as well.

Dr. Weitz:            Do you find any particular nutritional supplements to be of benefit with patients with inflammatory bowel disorders?

Dr. Rahbar:         Right. I mean, I think to answer that question I would say first one needs to change the mindset as what are we trying to target.

Dr. Weitz:            Right.

Dr. Rahbar:         Traditionally, the models of care fall into blocking inflammatory pathways or inflammatory compounds. We need that to keep it under control. But you still have to go back and see how do I get here. What went wrong? From my experience, we know a lot of patients have ability issues in their small bowel level. So some of the concepts that they deal with  leaky duct and the intestinal permeability issues that would help to repair the small bowel may give a fresh benefit to reduce the inflammation elsewhere. Be it the inflammatory bowel disease or some other inflammatory component in the body.

So the things we do in elimination of some of the foods that may not be desirable. The second thing is that if I feel the patient is malnourished or if they’re not able to break down protein, I may use pure amino acids as a supplement. We frequently use oral immunoglobulin because the data suggests that it does help with surface healing. We have used a peptide called BPC157, which is a 15 amino acid peptide, is made in the stomach juice. The research and this goes back to the 1990s by a professor from Europe. It seems that to be very helpful for our patients and it’s very safe to try it out.

Dr. Weitz:            How is that administered?

Dr. Rahbar:         In our practice, we use it orally as opposed to injection. I know there are some orthopedic indications for that and they use it by injection. But it’s cumbersome. I think for peptide that is made in the stomach considerably, I can just swallow it and be fine. It’s very stable in the stomach acid so why not do it that way?

Dr. Weitz:            That’s by prescription?

Dr. Rahbar:         It is not pharmaceutical, but it’s not quite nutraceutical. So it is some research and monitoring and education. So it still requires prescription for that.

Dr. Weitz:            Interesting. Yeah. Peptides seems like a new interesting part of the Functional Medicine playbook.

Dr. Rahbar:         Exactly. So other things we use, we use frequently zinc in the form of zinc carnosine. We use omega three fatty acids. I use vitamin A, because I think it may help with the infections and also surface healing. Vitamin D for keeping the immune system in balance. Some general multivitamins including the Bs, anything that will actually help to improve surface healing. Because when you look at the blood surface, you’re looking at a huge area of one layer of cells, and if there’s infection or malnutrition associated with it, you have some holes in there. The stem cells are not able to rapidly replace those cells that are lost. Practically every five to seven days, the surface area of the gut tends to get self-replaced. So we need to have a lot of nutrients to the other to accomplish that.

Dr. Weitz:            Do you run any of the nutrition panels to see what their status is of vitamins or amino acids or things like that?

Dr. Rahbar:         Yes. We do. Because it’s not always easy to predict what micronutrients we would be missing. A variety of these tests tend to be not available by blood but by urine test, for example, in children and it’s easy to do. They’re not that expensive. Use some guidance as how to deal with it. Of course we use clinical judgment, but I find those to be valuable as well.

Dr. Weitz:            Great. So what you’re saying is, I’ve looked at some of the papers about using nutritional supplements for inflammatory bowel disorder, and I think some of the authors still have this medical model. We’re just going to use this basically a supplement as a drug. But if you’re really applying a Functional Medicine model, you’re trying to analyze what are some of the underlying root causes and triggers and imbalances in the body. Then using nutritional supplements specifically to try to sure up some of those deficiencies and imbalances and things like that rather than just saying, “Instead of using this drug, we’re just going to use (name whatever the nutritional supplement is).”

Dr. Rahbar:         Right. I wish I could tell you you could call it one for everybody. But the purpose of nutrient replacement, especially at the micronutrient level, will be mostly for three areas. One is for providing the basic elements that several replenishment would require as you create cells again, you’re going to need yours. The second thing is to support the liver and other types of detoxification. Otherwise when you go to the area of detoxification, many things can add to this and we are constantly exposed to compounds in our bodies to clear that. Another one is basically what I call mitochondrial support. Energy speaks to that. If somebody is starting to feel fatigued, there is a problem with mitochondrial dysfunction, and obviously everyone knows that we don’t want to challenge our mitochondria. So the energy would actually be one of the greatest indicators of how we’re doing this to help it.

Dr. Weitz:            So what kind of supplements or foods would you use to help support the mitochondria?

Dr. Rahbar:         The basic nutrients would be important. Amino acids. We use a variety of antioxidants, in addition to some herbal products. There are really great combinations out there to do that.  Depending upon the number the patients are taking, what combinations, I don’t want to stick to one specific item. But anything that will improve the rate of antioxidant effect or indirectly by stimulating the NRF2s levels in the liver I think will give you benefits in the recovery.

Dr. Weitz:            Yeah. I personally found curcumin to be a really beneficial supplement in some of these patients.

Dr. Rahbar:         Exactly. Again, it has anti-inflammatory effect. You can use it with boswellia as well. If you use curcumin, the amount of the product is to increase about three to five grams a day. If it’s liposomal, it probably would be better. That could be piggybacked with everything else that we’re dealing with.

Dr. Weitz:            Yeah. I would caution practitioners out there if you decide to use curcumin, I personally have found that if you use the form that’s combined with black pepper at high dosages, that tends to be very irritating for the gut. So I would not use that form for these types of patients.

Dr. Rahbar:         Thank you, Dr. Ben. Great feedback.

Dr. Weitz:            Have you ever tried a worm or helminth therapy for these conditions? I interviewed a doctor from Duke University–Dr. William Parker–talking about some of the new worm therapies that are being used. I guess there’s some anecdotal evidence and some limited studies showing that some patients get great benefit from actually ingesting worms.

Dr. Rahbar:         Right. I’m personally not ready for that yet. Maybe just because I’m very conservative. But I’m not quite comfortable with that approach. I think we need to know more. The research is not entirely clear. Sometimes these bugs can take over if somebody’s highly immune suppressed. So I’d be very careful with that, if you will. At least for now.

Dr. Weitz:           I think there are several helminths that are being used now that tend to be self limiting, meaning that they’ll live a certain period of time in the human gut. Then unless you keep ingesting more, they’ll die off. So I guess there’s a certain amount of safety there. But I don’t blame you for being a little bit cautious until there’s some more research on helminth therapy.  What about fecal microbial transplant? I’ve heard some other doctors talk about this, especially for Crohn’s disease. Several doctors I know feel that this is probably going to be approved at some point in the near future by the FDA for Crohn’s disease.

Dr. Rahbar:         The research is there and it’s very strong. The three countries that I’ve seen are doing a lot of research on this are Netherlands and Australia and Canada. When you look at the research, they’re not exactly similar to each other. They’re all doing something a little bit different. I can tell you that from what I learned C-Diffocele, for example, if you do one fecal transplant, it may knock off the infection. For inflammatory bowel disease, this probably has to be FMT transplantation, and it’s not entirely clear. Does it need to be done daily or is it weekly? Do you use one donor or multiple donors? The universities are into discussion on this subject.

I just reviewed a nice article on this, and I can make it available as a question and answer group. One of the professors from Canada. The bottom line was that we’re not ready for prime time. A lot of unanswered questions. With Crohn’s, particularly, it may have to be swallowed to populate the terminal ileum. If you have overgrowth or bacteria in the small bowel, that may be an issue. A lot of unanswered questions and I wouldn’t rush into this at this time.

Dr. Weitz:            I think some patients are going to be a little apprehensive about swallowing capsule filled with poo.

Dr. Rahbar:         Yes. Well, it’s out there for a purpose, but we’re not quite there yet.

Dr. Weitz:            By the way, for those listening who don’t know what fecal microbiol transplant is, can you explain what that is?

Dr. Rahbar:         It’s basically a purified form of the bacteria that have been obtained from fecal material from volunteers that have been screened to be healthy. They’re available in frozen format through the rectum. Some people do it by colonoscopy installation, if you will. But to do it for IBD, most likely has to be done through the rectum like an enema without doing a colonoscopy. They also have them in capsule that open up in further down small bowel. Again, I think these probably have a role. We just don’t have enough information to make it publicly available.

Dr. Weitz:            Yeah. Great. So this was some really good information. I think for those who are dealing with patients or patients who are listening to this who have inflammatory bowel disorders like Crohn’s and ulcerative colitis, who may not be aware, there are alternative functional medicine approaches like the one that you use, Dr. Rahbar, to help besides simply having to take some of these drugs that sometimes have a lot of side effects for years on end. I personally have seen patients even taking some of these drugs still really bad symptoms and just got used to having six to eight loose bowel movements a day, constantly running to the toilet, having to plan their day around it. After applying a Functional Medicine approach, looking for triggers and food intolerances and nutritional imbalances and things like that, found that they could live a much healthier, happier life, and were either able to reduce or eliminate some of their medications. So I think that’s a great thing for patients out there.

Dr. Rahbar:         Absolutely. I mean, lifestyle is very important. For example, stress is usually a huge modifier of an inflammatory response by weakening the immune system, making more susceptible to infections. At the same time, turning up the heat in the way that is used in fighting back against the body itself. Sleep is a great issue, and also doing some regular exercise. I want to show you this article. This is in the Traditional Journal. Can you read that? Here is a reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995194/ 

Dr. Weitz:            Yeah. IBD patients are falling short on exercise and sleep.

Dr. Rahbar:         But look at the reference is Center for Disease Control.

Dr. Weitz:            Right.

Dr. Rahbar:         This is more traditional model. I think if the emphasis is coming out, that these other ancestrally lifestyle modifications will be very, very important. We generally tell our patients to eat slowly and chew well and not eat before they go to bed. Obviously limit carbohydrates. The issue of fish and tuna and sushi, these are important. I’m not in favor of having these sorts of proteins frequently taken without knowing what the exact source is. We frequently find heavily metals in our patients, and that will definitely change the intestinal microbiome. It’s probably going to increase the risk of yeast problems. It’s going to confound this in you.

Dr. Weitz:            So do you test your patients for heavy metals?

Dr. Rahbar:         Yes. We routinely do. I don’t do necessarily chelation to see what’s in the tissue. At least I do not want to see it in the blood floating around.

Dr. Weitz:            Right.

Dr. Rahbar:         Because once you eat let’s say tuna, it may take three to four weeks for a normal person to eliminate that from the blood circulation. Once a week may still be too much.

Dr. Weitz:            Yeah. According to Dr. Chris Shade, a patient who’s sick, who’s system is not working well at detoxifying, once you ingest mercury from fish, it can be in your system for over 200 days.

Dr. Rahbar:         That makes perfect sense. Yeah.

Dr. Weitz:            Yeah. So then you also mentioned mold is a factor. Do you often find that with inflammatory bowel disorders or sometimes you find it?

Dr. Rahbar:         Yeah. We look for anything that potentially can turn up the inflammatory process and produce immune dysregulation. The issue of environmental toxicity is extremely interesting and important because for a variety of susceptible patients who have the proper genetic profile, exposure to the mold and the process of mold may be a huge additional burden, if you will, and can be another dis regulator. Now, you add that to stress, add that to alcohol, to sugar, to bad lifestyle, add that to mercury and lead and we have a whole soup of events going on here. We also have several patients where they had some manifestation that suggested neuropathy. When we checked, we found there was evidence of tick borne illness or vector borne illness as another component of immune dysregulation. 

Dr. Weitz:            So you’re talking about something like Lyme disease.

Dr. Rahbar:         Yes. I’ll give you an example of scenarios. For example, the patient who comes with constipation, but when you do colonoscopy, you see colitis. The patient is taking laxatives and a part of the colon looks black because of the laxative use. But in another part of the colon is read and inflamed. So that suggests to me you have two problems. One is the nerve component of the colon is not working. So that’s neuropathy. The other part is immune dysregulation and colitis. What would cause this type of combination? Usually it would be vector born illnesses like bartonella, borrelia and babesia are very, very powerful to create this type of combination, if you will.

Dr. Weitz:            You mentioned immune dysregulation and that’s something that’s hard to wrap your head around. When you think of an inflammatory, an autoimmune disease, an inflammatory bowel disorder, you’re thinking you have a situation where the inflammation is revved up. But now you have these patients where the immune system is revved up and attacking but actually a lot of times the immune systems not working probably. So can you explain that? How do you end up having an immune system that’s in attack mode, but it’s actually not working that well?

Dr. Rahbar:         Well, simply what it means is in attack mode against our own tissue, but since it’s too busy doing that, it won’t be able to fight infections properly. So if you end up picking up a bug here, you’ll end up with scenarios where this low grade infection may stay in the body and they produce what we call the stealth infection. This term unfortunately is not in the classic books. We think about chronic infections with antibiotic. But what stealth infection is is a little bit different. You have to do your own reading on this, because you won’t be able to see it in classical descriptions. What it simply means that the Koch postulate that one bug causes one illness is probably not true at least nowadays. What we see is a variety of infections, it could be bacterial, viral, fungal. They work in harmony with each other. They keep the host busy, and they just kind of mess up the system a little bit. Just a little bit, won’t kill. But it’s uncomfortable. You can see evidence of allergies, skin problem, rashes, hives, itching, irritation, problems with sleep, joint problems, energy issues. When you go deeper, you see a variety of these infections may be sitting in the background. It’s hard to know which one is the creator. Sometimes you have to use kind of a try different things and see how you can hit the target.

Dr. Weitz:            So basically it’s not that the immune system is so much just up or down. It’s that it’s dysregulated, right?

Dr. Rahbar:         Exactly. Yeah. More change of autoimmunity and at the same time more chance of having difficult dealing with infection.

Dr. Weitz:            Right. Okay. Great. Lots of interesting topics. I’m sure we can talk about this for a long time. But I think you provided our listeners some great information. For those watching or listening to this podcast, how can they get a hold of you and get more information about you?

Dr. Rahbar:         The best way to approach us is to check out our website. We have tried to put as much information there. The telephone is always available. But telephone, once they ring more than two or three lines, there’s only one nurse.

Dr. Weitz:            What’s your website? Can you give that to us? Of course, I’ll put it in the show notes.

Dr. Rahbar:         Yeah that would be LA then the word integrativegi.com.

Dr. Weitz:            Great. What’s the phone number to your office?

Dr. Rahbar:         310-289-8000.

Dr. Weitz:            Great. You’re available for consultations both in person and remotely?

Dr. Rahbar:         Yes. Still in practice.

Dr. Weitz:            That’s great.

Dr. Rahbar:         Thank you.

Dr. Weitz:            Thank you, Dr. Rahbar. Look forward to speaking to you soon.

Dr. Rahbar:         I hope so. Thank you for this invitation.