Dr. Marc Ryan discusses Hashimoto’s Thyroiditis with Dr. Ben Weitz.

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Podcast Highlights

In this episode of the Rational Wellness Podcast, Dr. Ben Weitz hosts Dr. Mark Ryan, a licensed acupuncturist, herbalist, and functional medicine practitioner, to discuss Hashimoto’s Thyroiditis, the most common autoimmune condition in the US. Dr. Ryan shares his personal journey with Hashimoto’s and his path towards specializing in its treatment. They delve into the causes, symptoms, and the complexities of managing this condition, emphasizing the importance of a holistic approach. They also discuss the nuances of various thyroid medications, the impact of diet, and the role of supplements. The episode provides insights into functional and traditional Chinese medicine approaches to treating Hashimoto’s, stressing the need for comprehensive testing and individualized care.
00:30 Meet Dr. Mark Ryan: Expert on Hashimoto’s Thyroiditis
00:59 Understanding Hashimoto’s Thyroiditis
02:52 Dr. Ryan’s Personal Journey with Hashimoto’s
05:45 Common Symptoms of Hashimoto’s
07:11 Conventional vs. Functional Medicine Approaches
07:46 The Role of Thyroid Hormones
12:59 Autoimmunity and the Immune System
16:33 Comprehensive Testing for Hashimoto’s
20:13 Addressing Adrenal Dysfunction
21:28 Managing Blood Sugar Levels
24:14 Product Break: Apollo Wearable
25:45 Hypothyroidism and Its Effects on the Body
25:56 Understanding Hypothyroidism and Kidney Function
28:23 The Impact of Testosterone on Kidney Health
30:16 Thyroid Hormone and Heart Disease Risk
31:41 Nutritional Supplementation for Hashimoto’s
31:47 The Controversy of Iodine in Thyroid Health
37:30 Balancing Thyroid Medication
38:52 Dietary Recommendations for Hashimoto’s Patients
43:51 Final Thoughts and Contact Information
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Dr. Marc Ryan is a licensed acupuncturist, herbalist, and Functional Medicine practitioner.  He’s written two books about Hashimoto’s thyroiditis, How to Heal Hashimoto’s and The Hashimoto’s Healing Diet. He teaches at YoSan Acupuncture College, and his practice is devoted to treating patients with Hashimoto’s.  His website is HashimotosHealing.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz: Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.

Hello, rational Wellness podcasters. Today we’ll be having a discussion with Dr. Mark Ryan about Hashimoto’s Thyroiditis. Dr. Mark Ryan is a licensed acupuncturist, herbalist, and functional medicine practitioner. And we’ll be discussing Hashimoto’s thyroiditis, which is the most common autoimmune condition in the us and I’m just going to talk for a few minutes about Hashimoto’s to give us a little background about this condition.  So, while the prevalence of Hashimoto’s thyroiditis occurs in about one to 2% of the population, up to 20% of the population have positive thyroid antibodies. Women are affected five to eight times more frequently than men. Over 90% of those in the US with hypothyroidism have Hashimoto’s, meaning that their low thyroid is autoimmune in origin rather than a rising from an iodine deficiency called goiter.  Prior to 1924 in the United States, the main cause of hypothyroid was iodine deficiency. Especially across the northern part of this country and in Appalachia where the soil was iodine deficient, and this area was known as the goer belt. Iodine deficiency leads to enlargement of the thyroid knowns, goer, and in extreme cases can lead to [00:02:00] impaired neurological, stunted growth, physical deformities.  But starting in 1924, we instituted iodized salt. When this happened, rates of goiter dropped to very low levels, but rates of Hashimoto’s soared. A similar pattern has occurred in other countries around the world that have instituted iodine supplementation.

So, as I mentioned, Dr. Mark Ryan is a licensed acupuncturist, herbalist, and functional medicine practitioner.  He’s written two books about Hashimoto’s thyroiditis, how to Heal Hashimoto’s. The Hashimoto’s Healing Diet. He teaches at Yoan Acupuncture College, and his practice is devoted to treating patients with Hashimoto’s. Dr. Ryan, thank you so much for joining us today.

Dr. Ryan: Oh, thank you for having me.

Dr. Weitz: Great. Let’s start by talking about your story with Hashimoto’s.

Dr. Ryan: Yeah, so I, you know, I think like many [00:03:00] acupuncturists, I started out as a generalist and you know, worked for many years in, in a number of different other people’s practices. And then opened my own practice in San Pedro. Had a big multidisciplinary practice there for several years and I kind of, it was a big thing.  I kind of crashed and burned and got burned out and, you know, I was working like. You know, I’m sure you know, 12, 15 hour days doing long hours. And I just like burned the candle at both ends. And through that process, I ended up closing that practice and decided I wanted to, like, reimagine myself and what I was going to do with my career.  And I went and got some business training and one of the things that they said was you have to choose a niche. Like if you wanna be successful, you need a niche. So I was like, well, and I was thinking about my patient population. I thought maybe I’ll do thyroid stuff. You know, I always, I seem to have a lot of thyroid patients, even at that time for some reason.

And so I chose, [00:04:00] originally hypo, just hypothyroidism as the niche. And then six months later I was diagnosed with Hashimoto’s. Huh. And then, so that pro, you know, obviously it became not just a professional choice, it became a personal you know, mission. Because my experience with it, and this is experience I’ve had with lots of patients over the years, is I went, I had a good friend who was an MD.  He did all the testing. We did ultrasound, you know, found nodules. We found that my TPO was quite elevated. It was really high. I was at 1200. But all my other numbers were normal. And so it was basically, it was like, well, yep, you have Hashimoto’s, but there’s nothing we can do about it right now.  We’re just gonna keep an eye on it. And once it gets bad enough, which means, you know, that translates to once your thyroid’s sufficiently destroyed, we’ll put you on Synthroid and then you know, it’ll be fine. So it was at that point I realized like. Holy crap. Like they have nothing to offer in the Western medical model.  There’s really nothing for people who don’t have advanced [00:05:00] destruction of their thyroid with Hashimoto’s. So that really be kind of started my whole journey of learning and research and studying and working with people to try to find solutions for things that. You know, we have

Dr. Weitz: before it gets that bad.

And by the way, this is also the reason why most medical doctors, even endocrinologists, rarely test for thyroid antibodies. And if they do test, they’ll never test again because there’s nothing they can do about it.

Dr. Ryan: Correct. They don’t, it doesn’t change their treatment strategy. One iota. If they find the person has, you know, antibodies if the antibodies are a hundred or if they’re 3000, you know, it does, they do not do anything differently.  Yeah.

Dr. Weitz: So, what are some of the most common symptoms that somebody with Hashimoto’s can have? Which, what symptoms did you have?

Dr. Ryan: Yeah, I mean, it’s, three of the most common are fatigue brain fog and weight issues, [00:06:00] usually trouble losing weight, although there’s a whole. You know, sort of subpopulation that has trouble gaining weight.  Those are the common, most, three common symptoms. Hair loss is another one, which is particularly troubling for women sometimes. Dry skin, usually some sort of gut. Dysbiosis or leaky gut or some gut prop. Food sensitivities are also very common. Joint pain is quite common. But the top three are brain fog fatigue and, weight gain. I didn’t have any weight issues really, about my top symptoms were brain fog and fatigue. I had pretty severe brain fog. I remember one day I, a patient came out I had for 12 years and I could not remember their name, and I was like, oh, so’s in my brain right now.

Dr. Weitz: Yeah. I, by the way I also have Hashimoto’s and have never Oh, really?  I didn’t know that. Yeah. I’ve never taken thyroid medication and I’ve been dealing with it using a functional medicine approach as well.

Dr. Ryan: Yeah.

Dr. Weitz: I’ve actually to my knowledge, never [00:07:00] had any symptoms. My TPO antibodies are, you know, around a hundred, 150, so it seems to be a lower level, but I’ve certainly been working on managing it.  So, what a patient sees a conventional medical doctor with Hashimoto’s, how did they get treated?

Dr. Ryan: Yeah. If you go to see a conventional medical doctor, usually the first line of treatment, if they see. Some imbalance in your numbers. If they see elevated TSH or some Usually they just test TSH and maybe Right.  TSH is really the one number they really focus on. Right. So they find that the TSH is elevated out of range. They will usually prescribe Synthroid.

Dr. Weitz: Right. Which is essentially synthetic T4.

Dr. Ryan:  Correct.

Dr. Weitz:  Can you explain what T4 and T3 are and what TSH is?

Dr. Ryan: So, TSH is produced by the pituitary–Thyroid Stimulating Hormone, and basically it’s, your brain gets signals from the body, [00:08:00] and then there the, through the HPT axis, the hypothyroid, pituitary, and thyroid axis, it signals the thyroid.  And tells the thyroid to either produce more thyroid hormone or less. And in the body produces naturally about 12 parts, T4 to one part T3, and that T4 has to be converted into T3 for it to be biologically functional and most of that happens in the liver. About 60% in the liver.  Another 20% of that conversion happens in the gut with good bacteria, and then the final 20% happens in the peripheral tissue. So the body has to go through that process of conversion and then also it has to then absorb the thyroid hormone properly. All, you know, all the cells in the body have thyroid hormone receptors.  But there can be problems, and I think this is where we come in as natural functional medicine practitioners. There can be problems with conversion, there can be problems with absorption you know, all along the way there. So [00:09:00] just taking medication doesn’t always guarantee that it’s gonna function properly in the body because of that whole process.  Right.

Dr. Weitz: And can you explain what T4 and T3 are?

Dr. Ryan: Yeah, so T4, as I said, body produces mostly T4. It’s not the biologically active form, although it does do some things within the body, but by and large it has to be converted to T3, which is the biologically potent form of T3, that works on the cells and causes the metabolic changes that it does.  And T3 is so active. That your body actually has mechanisms for turning it off. There’s something called reverse T3, which also happens in the liver, where if you’re under times of stress if your adrenals are too taxed or if you’re iron deficient. Then the body will take that T3 and make it inactive just because it, it’s so metabolically potent [00:10:00] and, you know, can cause stress and other things.

Dr. Weitz: And if in case there’s some lay persons listening to this who might not understand how important thyroid hormone is, can you explain why thyroid hormone is such an important hormone?

Dr. Ryan: Yeah, I mean, in Chinese medicine we sort of view it as a v. The personification, if you will, of kidney yong, which is your body’s metabolic fuel in a sense.  Every cell in the body has thyroid hormone receptors. It is what powers the, you know, it’s like the engine that powers the function in your body. So whenever you are hypothyroid, whenever you are, if you aren’t absorbing it probably, or your body’s not utilizing it properly, it can affect every system of the body.

One example is the liver. Like when someone’s hypothyroid it’s everything. All the processes in the liver slow down. So often you’ll get elevated cholesterol and other problems as a result, just because that [00:11:00] metabolic energy that fuel. It is not being processed and utilized properly and everything slows down.

Dr. Weitz: Essentially, the thyroid is the master regulator for every cell in the body.

Dr. Ryan:  That’s exactly right.

Dr. Weitz:  Every tissue in organ. So let’s go into proper testing. Yep. When you wanna assess the thyroid besides looking at the whole person and their symptoms, et cetera, what lab tests should ideally be run?

Dr. Ryan: Yeah. So I mean, for me it’s always important to do as complete a thyroid panel as possible, particularly if it’s the first time that person’s being tested or if it’s someone who has not been tested for some time. So that would be the TSH I would. Order the total T three and the total T four.  That’s the amount of T four and T three that are, is both free in the body and it’s bound to proteins. And then I would also order the free T four and the free T three. These are the free fractions. What is bioavailable? I like to also look at the [00:12:00] reverse T three. Most MDs will not. Order that test. But I like to look at that test ’cause that can tell us something about conversion.  If you look at the ratio between free T three and the reverse T three and then the two antibodies which tell us I, is there an autoimmune process going on that’s TPO or thyroid peroxidase and TGAB, which is a thyroid globulin antibody. So a complete thyroid panel would include all of that so that we can really assess how the thyroid is functioning.  And whether or not the autoimmunity is part of the equation. 

Dr. Weitz:  So, autoimmunity in the conventional medical world is either ignored as in cases of thyroid autoimmunity, or in other forms of autoimmunity. There are medications that suppress some or all of the immune system. In the functional medicine and traditional Chinese medicine world, how do we address autoimmunity?

Dr. Ryan: Yeah. So what, [00:13:00] first of all, what is autoimmunity? Autoimmunity is like the body has lost the ability to recognize itself in a sense, right? It’s, you, your immune system has flagged your own tissue as an invader and is attacking it. So. What we wanna try to assess is how is that imbalance occurring within your body?  Are there different parts to the immune system? What we call t th one, TH two, TH three, TH 17. These are all th stands for T helper cell. One of the things we do in functional medicine is we assess, well, what is this relative balance of these different parts of the immune system and where it may it be overzealous.

You know, at first there were theories about Hashimoto’s being a th one dominant condition. I think OO over time research has shown this, that maybe it was an oversimplification, but there’s usually some kind of imbalance there in, in the th one or th two aspect of the immune [00:14:00] system. And then th three is, so see, let’s explain what those are.

Th one is kinda like the frontline of attack the immune cells that, that do the actual tacking of pathogens. TH two is the antibody system. I think of that sort of as like military intelligence, if you were to use it thing that your immune system is flagging certain parts of that certain parts of the, of your own body with autoimmunity, but other.

Pathogens when it’s, you know, fighting a virus or bacteria. And then th three is sort of the command and control structure. This is the part of the immune system that is overall balancing this process. And so we wanna try to assess that and calm down the attackers, you know, quiet that portion of the immune system and strengthen that.

Command and control structure, which is what Vitamin D and glutathione are both very helpful for. Right.

Dr. Weitz: So what are, what how do we understand how our body gets dysregulated? You know what, [00:15:00] why would our immune system start attacking our own cells?

Dr. Ryan: That’s a great question. There are a number of different theories for that.

You know, some, there’s a theory called molecular mimicry. Correct. Where the, you know, immune system sees you know, your own cells as similar to a pathogen, I think sometimes. And I

Dr. Weitz: think that’s one of the most,

Dr. Ryan: Dominant thoughts in this

Dr. Weitz: world, right?

Dr. Ryan: Right. Yeah. It’s one of the top theories on it.

You know, I think autoimmunity itself is a perfect storm. There’s a, there’s usually a genetic component. There’s usually exposure of some kind of pathogen, like Epstein Barr for example. You know, in that case, you know, Epstein Barr can attach to thyroid tissue, and then you kinda get this hybrid of your own tissue and Epstein Barr and all combined and the immune system just flags that.

And you know, your own cells are kind of, you know, the. The residual victims of that. There’s [00:16:00] also usually, you know, stresses is definitely a big component to the onset pregnancy for women is sometimes an onset. And usually some kind of gut dysbiosis or, you know, problem in the gut too.

So it’s usually it’s definitely a, not a single cause I don’t think. I think it’s really a perfect storm of all these things. So,

Dr. Weitz: let’s see. We talked a little bit about testing, so, let’s go into how we handle patients with Hashimoto’s and what’s the first thing you like to look at?

Dr. Ryan: Well, I’ll definitely do a thyroid panel, but I like to do also a more, much more complete panel just to see what other systems are being impacted and how, so we want to, you know, do a lipid panel. We want to look at the liver, do a lip, a liver panel, look at the kidneys, how they’re functioning to a renal panel, you know, comprehensive metabolic panel.

We wanna look at red and white blood cell counts, you know, how’s that being impacted? We wanna check [00:17:00] to see are they anemic? So we do an iron panel as well. And look at ferritin. It’s very important since this is not just a thyroid problem, it’s really a systemic problem because of the influence of thyroid hormone.

We really need to assess the entire body and see what’s going on. So we’ll look at all those things. Look at blood sugar metabolism, how that’s you know. In the person. I also, you know, I like to think in terms of this, the endocrine triangle, that’s the thyroid, the adrenals, the blood sugar, the pancreas all is one system really.

So we, we want to check and see how that is all being impacted. And then, you know, we have to treat, we have to prioritize what we find in that process and you know, treat the patient holistically in their entire body. Do you look at food sensitivities when you do your testing? I do, sometimes I do.

Yeah. I mean, it depends, you know, that’s part of the intake process we wanna see, you know, are they having [00:18:00] food reactions generally, you know, even if I don’t do testing, I generally advise people to get off of gluten and dairy just because it can have such immune stimulating effects that can make your auto autoimmunity worse.

And people often do have food sensitivities, but it’s not usually the first thing that I will test. I generally do just the blood tests first to. To assess how the system is right,

Dr. Weitz: so when you book, you address how you explain how adrenal stress has an effect and reduces the conversion of T four to T three.

So that, that’s why talk about the adrenals and how that affects the thyroid.

Dr. Ryan: Yeah. So that’s why it’s important that we assess that, that triangle that I was just alluding to. The and that’s the stress piece, I think too. Right? That’s the there’s, has a huge the adrenals it’s interesting.

In Western medical model, the adrenals are not really

Dr. Weitz: Yeah. Unless there is Cushing syndrome. Exactly. Unless it’s super advanced, really extreme. They don’t recognize any other [00:19:00] adrenal problems. And I think part of that’s because of the way they test for it.

Dr. Ryan: Oh, right, exactly. Because they’re.

What is testing for the adrenals in West Medical in A CTH, which is the equivalent of TSH in the adrenals. Yeah, so it, and it’s serum cortisol, right? And right and cortisol in the bloodstream. What I do like to test is do to do a saliva test the four point cortisol saliva test, which we take samples of saliva four times throughout the day and actually look at the circadian rhythm and how the body is processing.

Cortisol and how that’s impacting everything. But yeah, I think the point that you brought up is very important and that is that stress and too much cortisol being produced and adrenal dysfunction has a huge impact on the thyroid. And I think one of the main reasons is there’s that communication system between the brain, between the hypothalamus pituitary.

And these glands is so much the same, right? There’s the [00:20:00] HPA axis, there’s the HPT axis, it’s the same communication pathways. And once they’re disruptive in the adrenals, they’re gonna be disrupted in the thyroid as well. So that it’s super important that we evaluate that.

Dr. Weitz: When you see a dysfunction with the adrenals, how do you address that?

Dr. Ryan: Depends what it is, but generally we wanna, we want to you know, really look at their circadian rhythm, what’s going on, how are they, what’s their sleep hygiene like, you know, how is their sleep? What is their blood sugar, you know, balance. Like are they hypoglycemic, are they insulin resistant? Like where are they in that?  ’cause those two things are also very much intertwined. So, you know, part of the first thing to assess is, okay, how. How are, how is your sleep? How is your circadian rhythm? Are you know, taking care of that piece? And then often we’ll do things to try and reestablish that communication between the hypothalamus and pituitary by using app adaptogenic herbs perhaps.  [00:21:00] Or you know, in Chinese medicine we’ll do an approach where we’ll work on that kidney yang and kidney in balance. There. But I think, yeah it’s all, again, the holistic approach is it looks at blood sugar stability, get that communication from the brain and trying to establish and rebalance those.

Dr. Weitz:  So, why is blood sugar such a common problem and how do we properly assess blood sugar?

Dr. Ryan: Yeah, so blood sugar issues are maybe the most, and when I say

Dr. Weitz: blood sugar we really mean insulin resistance is probably right, the main problem.

Dr. Ryan: But even, I mean, we see both things.

We see both types of dysfunction, like hypoglycemia is also a major problem. For people with Hashimoto’s. Yeah. It’s just the other end of the spectrum. It’s just the, that bloodstream mouth, but Right. So let’s explain what those two are. So hypoglycemia means you have too little sugar in the blood.

That, those are the type of people who you know, they can’t skip meals. They get really like lightheaded or [00:22:00] hangry. Often we’ll also see, you know, low triglycerides, which are sugar stored as fat, like they have no sugar reserves. So, you know, these type of people are really vulnerable to their blood sugar crashing.

And that has an entire impact on the thyroid in the system. And those people usually on

Dr. Weitz: their way to high blood sugar.

Dr. Ryan: Correct. Right. That’s usually earlier on in the progression that, that imbalance. And then the other side of that is insulin resistance, which is also called metabolic syndrome, which is you know, pre-diabetes that, that pathway towards becoming a type two diabetic, which is, you know, an incredibly common problem we have in our culture because I think a lot of processed foods have so much sugar and.

Whatnot. And so that’s the opposite problem, where you have too much sugar in the blood and then that can lead like to things like, you know, elevated ferritin where you can’t access iron either until you get this like double. You know, [00:23:00] fatigue problem because of that imbalance. So, w with that, we really wanna assess, we wanna look at their fasting glucose, look at their hemoglobin A1C, look at their lipid panel, look to see how they’re processing sugar and how it’s being utilized in their body.

And try to, you know, get people to be conscious about. Stopping these huge spikes and crashes of sugar in their daily life and create more balance throughout the day. How do they do that? Well, generally, again, we have to figure out where they are on the spectrum, but we, you know, that first starts of the, you know, it’s not really an old wives tale, but having a good breakfast is actually a critically important thing where you have you know, ellos, frosted flakes, starting the day with sugar is a recipe for disaster because you, that’s exactly what happened to you.

Like you’re sure. Hits this roof and then you crash a couple hours later and then the rest of your day is trying to make up that. So yeah, we wanna start the day with a good protein, a good fat [00:24:00] balance making sure then from there on making sure we’re, you know, wherever you are on that spectrum, you’re eating frequently enough throughout the day so your sugar doesn’t crash and you’re not, you know, binging too much on carbs and sugar along the way there.

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So go to Apollo Neuro and use the promo code Whites today. And now back to our discussion. In your book you talk about how hypothyroidism can lead to decreased blood flow to the kidneys, increased uric acid, even high blood pressure. Can you talk about [00:26:00] that?

Dr. Ryan: Yeah, so. Again because of thyroid hormone is so influential on so many different systems.

Whenever you’re hypothyroid or something, I call functionally hypothyroid. If you, sometimes we’ll have enough thyroid hormone in our system, but because of thyroid receptors being blocked or just systemic inflammation or this blood sugar stuff that we’re talking about that can lead to.

Other systems being impacted and not functioning properly. So we can see that with the with blood pressure and the kidneys usually it it starts as low blood pressure, but over time it, it can kinda snowball into a problem where you actually end up with high blood pressure.

Dr. Weitz: Yeah. And we, you know, I see a lot of patients who do a lot of labs.

Who are trending towards having kidney problems. And I think it’s often unrecognized when we look at kidney function tests that a lot of times we’ll use [00:27:00] aerial filtration rate EGFR. Yeah. And on the labs it says anything over 60 is fine. Right. The reality is. When you get below 60, you’re actually at grade three.

Kidney failure, right. Precise. One and two are much higher than that. So 60 really should not be the cutoff for assessing thi kidney function.

Dr. Ryan: Right. Exactly. I mean, funny brings up, I had a couple patients last week, like two opposite issues resulting in, in kidney damage in the decline of the EGFR and that’s explain that.

CGFR is blood flow in the kidneys. It’s actually how your kidneys are processing blood and therefore how everything is working through them. And you’re right. What. In the Western medical model, there are five stages of chronic kidney disease and after stage three a, it’s a really big problem.[00:28:00]

Like the, you know, that’s where you’re

Dr. Weitz: and stage three starts at below 60. Right. So, so somebody comes in with 65, they’re already at stage two kidney failure.

Dr. Ryan: Correct. So like that’s why it’s so, but the labs say normal. That’s why it’s so important for us to check and evaluate this. So over the last week, I had a couple different patients.

These weren’t Hashimoto’s patients, but it was very interesting to see. One of them was this elderly man who’s, you know, this is in vogue right now where people are being put on, you know, large amounts of thyroid hormone replace, not thyroid of hormone replacement. This elderly man who’s 81 years old, was put on like huge doses of testosterone.

How are a dosage. His testosterone was over a thousand. Okay. On the blood test. Okay. I don’t remember what the exact dosage was, but anyway, they brought me in like four years worth of lab work, and you could see this steady decline of EGFR. So it went from, you know, like [00:29:00] in the eighties to the forties.

Right and through, as it was charting it, you could see when he was aggressively dosed testosterone, just like the absolute immediate decline of kidney function. And basically what was happening was he was, they were, you know, causing intrinsic kidney damage with this aggressive supplementing, you know, so this is one of those things where, yeah, thank God they.

Hey, thank God that came to me, and we could figure out what the problem was and stop it so that it doesn’t have further kidney decline. And b, that, you know, like there’s consequences to doing things.

Dr. Weitz: Like, hey, everything should be in some sense of balance. Some sense of balance, yes. Yeah. Not that hormone replacement is bad, but.

Dr. Ryan: No, it’s, it could be appropriate. Yeah. But you gotta be paying attention to how it’s impacting the rest of the system. And then the other case was interesting, got sort of opposite problem. The person who had pretty [00:30:00] significant B12 deficiency and that ended up causing like high elevations of homocysteine, which is inflammatory mark and causes inflammation in the arteries.

And that was, you know, impacting blood flow to the kidney. And he was also experiencing decline. In kidney function, EGFR as a result. So,

Dr. Weitz: Can point now, hypothyroidism increases risk of heart disease. You mentioned in your book it can increase cholesterol, which you just mentioned. I think a lot of people are somewhat aware of that, but it can also increase homocysteine levels, right?

C-reactive

Dr. Ryan: protein. Right. So, so again, because of the influence of thyroid hormone on all the systems. We see, like I said it’s very, when you’re hypothyroid, it’s very common to see elevations in cholesterol and the other lipids. Also, one thing that there’s definitely been an established link to is the M-T-H-F-R gene mutation and Hashimoto’s.

And that can lead in and of [00:31:00] itself to elevated homocysteine. In fact, like, you know, I teach my students one of the poor man’s tests for elevated homocysteine or sorry, EZ test for M-T-H-F-R mutation is elevated, cysteine over 15. So that basically what you have is this combination of risk factors that increase the possibility and the probability of some kind of heart disease and heart problem.

You get those elevated lipids, you get the high homocysteine, which is impacts blood flow and causes inflammation in the arteries. You get just general inflammation, which we see with the C-reactive protein. You get this, again, another sort of like vicious cycle or perfect storm. Of risk factors that can lead to more problems.

Dr. Weitz: So let’s talk about the potential benefits of nutritional supplementation for patients with Hashimoto’s. And let’s first start with the most controversial nutrient, which is iodine.

Dr. Ryan: Yeah. So Ida this is like one of those areas

Dr. Weitz: where there’s by the way, let me throw an anecdote in there.[00:32:00]

So I have Hashimoto’s and my TSH has been for a lot of years between around seven and eight. Then one year it went up to nine. I decided I would try the high dose iodine. I took 12 and a half milligrams and my TSH went up to 25. So stop that. Exactly. So eating anything that had iodine in it, like seaweed.

Figured out what else I needed. I was really low on zinc. I have a gene that can’t absorb zinc, really ramped up the zinc supplementation as well as the vitamin D, as well as selenium. And then I got my TSH to between four and five.

Dr. Ryan: So perfect antidote because that is exactly what happens with Hashimoto’s patients, who, in my experience, who do high dose iodine.

I I think that’s really the problem, is it’s just excessive amounts. Like we, the reality, we, our body does not need that much iodine for [00:33:00] thyroid function. It’s very important. But the amount we actually need is relatively small, right? So, so if you’re gonna, you know, having seaweed occasionally is actually sufficient.

And I take a multi that

Dr. Weitz: has 150 MCG, and that’s fine.

Dr. Ryan: Right, right. So I think the controversy and the problem really is with excessive iodine, right? Supplementing and that can cause, you know, the, your autoimmunity to flare too. So, particularly I iodine salt is also problematic for autoimmunity.

And when you combine those two in relatively high doses, that’s a real recipe for disaster for the someone with thyroid autoimmunity.

Dr. Weitz: Now, why is iodine salt worse than, say, supplements iodine or eating seaweed?

Dr. Ryan: It’s because salt. It can also you know, amplify the autoimmune process.

Just the sodium itself? Yes.

Dr. Weitz: Yeah. Okay. So what other supplements can be helpful [00:34:00] depending upon the patient? Well, yeah, of course.

Dr. Ryan: And do you test for nutrients? There’s a wide variety. I mean, I do test for some nutrients. You know, all common minerals. We wanna look at the things that are most important for thyroid function, like selenium and zinc like iron you know, so those are the most common ones I’ll look at.

Sometimes I’ll look at B12 and folate as well. Right. But, the, I think we were talking earlier about the different parts of the immune system. We wanna test vitamin D levels too as well to see, ’cause that’s gonna give us a sense of, you know, how do they have enough vitamin D to, to help strengthen that regulatory part of the immune system.

I think glutathione is a very helpful, supplement as well. It’s a Mastro antioxidant. I think in general, you know, we were talking about how a lot of thyroid hormone conversion happens in the liver. You know, so one of the things I see often too is with patients is that the, there will be [00:35:00] some reason that their thyroid hormone is not functioning as well, whether there’s thyroid hormone resistance or the systemic inflammation or what have you.

And then the doctors are just gonna keep increasing the dose and increasing the dose and increasing the dose, whereas and that in and of itself can cause other problems. So what I look at first is, okay, what. Where can we just improve this process by improving these other areas? So let’s maximize liver function.

Let’s make sure that we’re getting, you know, the liver’s detoxing properly, that it’s being supported properly. Let’s look at the gut and see is there any kind of dysbiosis there? Can we support the good bacteria and the microbiome and the gut? Let’s look at the systemic the rest of the body where we’re.

This inflammation, the systemic you know, in this peripheral tissue can cause problems. So, so let’s look at things that are anti-inflammatory, like, like turmeric or resveratrol or things like that. So, you know, I think we get a lot more, we have a lot more success clinically when we think that way.

Dr. Weitz: And I do [00:36:00] think that there is a relatively small sig, but. Significant percentage of practitioners who have adopted a philosophy that when it comes to thyroid. You supplement with thyroid hormone, if the patient doesn’t feel really well, you just keep increasing that dosage. And I’ve had a number of patients come in my office and they’re actually in hyperthyroid from pushing that dosage up so high and granted there may be a few cases, maybe with a history of thyroid cancer where you.

It may be justified, but just for the sake of managing symptoms, pushing that TSH so low with such an aggressive level of thyroid hormone potentially, I think is damaging to the body. And you’re suggesting other ways to try to bring the BA body into balance and address those other symptoms besides simply pushing the thyroid hormone higher and higher in the [00:37:00] body.

Dr. Ryan: And yeah, I think the danger of overmedicating, like we know. That it can lead, particularly in women that can lead to osteoporosis. If you’re too aggressive with thyroid hormone supplementation. The heart itself is very sensitive to T three and to thyroid hormone, so you can do damage to your heart by overmedicating.  There are, again, there are, you know, we were talking about the testosterone supplementation. There are consequences to overall supplementing, right? So we always wanna be looking at balance. Right.

Dr. Weitz: What about thyroid medication? Do you have an opinion about that?

Dr. Ryan: Well, I mean, I. I don’t really like have, people always ask me what’s the best medication?  Like, I, right. You know, so

Dr. Weitz: people say, oh, you should take Tyrosint. It’s better absorbed. You should use, right. You should use armor, you know, it’s natural. It has some T three you should use exactly. Synthetic T four with synthetic T three.

Dr. Ryan: Exactly the problem with that is I’ve seen basically every permutation of it and that it doesn’t always [00:38:00] work for people in the same way.

Like some people actually really do better with synthetic T four. Right? And then other people do need that additional T three that you get with armor or nature. Thyroid, and then, yeah, tyrosine. It can be a great choice because it comes in gel. There’s no filler, so we can eliminate that variable.

But, you know, I think there’s no like magic bullet way of figuring it out. You have to like experiment and you have to pay attention to what’s going on there. And you know, I’ve seen people on the flip side who have reacted to natural thyroid as though it was their own thyroid hormone and actually flared up their autoimmunity.

So, you know, that’s a very complicated, difficult question and often it’s just trial and error to we find the right mix for that person.

Dr. Weitz: So what type of diet is best for patients with Hashimoto’s hypothyroid, and should they stop eating [00:39:00] broccoli? Great question. I mentioned broccoli ’cause broccoli’s in a category of foods known as goergen.

Dr. Ryan: As goergen. Yeah. I’ll start with that. So I think. I liked your little history at the beginning talking about the, you know, the history of Appalachian, the goiter belt, and the fact that we didn’t have, you know, at that point in our history iodized salt and that’s impact that, that is ancient history for us, so, right.

The whole goitrogen. I think, you know, myth is part of that ancient history. It’s no longer an issue and I think the health benefits of broccoli and other, you know, those cruciferous vegetables far outweigh any problem that, that they may have caused. So I think that’s a complete non even.

Dr. Weitz: Just explain what this concept of greater gens is.

Dr. Ryan: Yeah. So the. These vegetables like broccoli, cauliflower, kale, the things of that family I. Can [00:40:00] potentially lead to more increase in, in goiter and nodules in the thyroid, which by the way are very common. The vast majority are benign, but you know, almost everyone will develop some sort of thyroid.  Growth, you know, before they die. So in, in large quantities in the absence of sufficient eye, by the way, how

Dr. Weitz: are they alleged to do that?

Dr. Ryan: The pro I, that’s a good question. Okay. Sorry. I don’t remember

Dr. Weitz: how they okay. Sorry, I didn’t mean to put you on the spot. So, but we have these gor units that are known to I, I think they’re supposed to block the conversion of T 40 T three.

Dr. Ryan: Right, right, right, right. Yes.

Dr. Weitz: And so they,

Dr. Ryan: right. They’re involved in that, but it’s usually, again, in the absence of sufficient amount of iodine. Right. That, that, that happens.

Dr. Weitz: Oh, so it’s a myth that e eating foods like [00:41:00] broccoli aren’t gonna make your thyroid function worse?

Dr. Ryan: I believe so. I believe so.

Again I think it’s the benefit far outweighs the negative of those because they’re very productive against cancer and thyroid cancer in particular. So just diet in general. I think this is a really interesting topic because I went through process for a while. You know, it was, there was a diet that was.

Super pop. It’s not so popular anymore, but it was called the Autoimmune Paleo Diet. Correct? Yeah. It’s I mean, generally I still am in favor of it but I learned something the hard way. Basically it’s a diet where it’s essentially the paleo diet where you’re, you know, minimizing carbs.

It’s just taken to the next level where you’re cutting out every, anything that’s potentially inflammatory. So you’re cutting out carbs, you’re cutting out dairy, you’re cutting out nuts and seeds. You’re cutting out legumes. So it’s a pretty restrictive diet, mostly you know, protein and vegetables.

But one of the things I discovered the hard way was that you can’t stay on that [00:42:00] restrictive a diet for too long because you end up degrading is known in the body as oral tolerance and oral tolerance is our capacity to adapt to different foods. And the only way we can do that is to be exposed to them.

So again, back to balance. You know, I often advocate people go on some sort of, you know, restrictive diet initially to just to calm the immune system. And so we can work on the gut, but it’s critically important that they don’t stay on that super restricted diet for too long because that in and of itself can cause problems.

Dr. Weitz: So, which is the best super restrictive diet to start on? Is it the autoimmune paleo?

Dr. Ryan: I like the autoimmune paleo. Yeah, I think that’s a, I think that’s a good approach. Yeah. So for, but like for 30, 30 to 60 days only, don’t go more than that.

Dr. Weitz: Right? Okay. So you can look that up. Basically, you avoid dairy, you avoid gluten, you avoid all grains, you avoid legumes.

You also avoid nuts and seeds, correct?

Dr. Ryan: Correct. All those different things and nightshades too. [00:43:00] For Right. For people. So it’s anything that’s potentially inflammatory. Right. And it works wonders in terms of calming down the immune system. Just again, you. We can’t stand it for too long,

Dr. Weitz: right?

Because it’s gonna lead to nutritional deficiencies and those foods you’re eliminating that can cause a little bit of inflammation. Also have many benefits that outweigh that. And having a little bit of inflammation means that you have a properly functioning immune system. Anyway.

Dr. Ryan: Right. Exactly.

Yeah. Our immune system is not meant to be completely shut off. It does good

Dr. Weitz: work for us. Absolutely. Which is one of the problems with medicating to suppress your immune system, right. Helps you fight you off infections, cancer pathogens, et cetera. Yeah, exactly. Yeah. Alright, great. Any, anything we haven’t covered that you wanna explain?

Dr. Ryan: Not really. This has been a great discussion. We, I think we’ve touched on a lot of [00:44:00] important things. I just think overall for people, you know, if you’re new to this, you’ve just been recently diagnosed with Hashimoto’s and you’re feeling lost or you’re struggling, just know that there’s a lot that we have to offer.

In the functional medicine, Chinese medical world for you if you’re feeling abandoned or you know, not that supported by your md. There, there’s a lot that we can do. And it’s generally pretty well and easily managed if it’s done properly,

Dr. Weitz: right? So simply taking Synthroid should not be the end of the story, and if you’re not feeling great after that.

You should really seek out a functional medicine practitioner like myself, like Dr. Ryan. How can listeners and viewers get in touch with you?

Dr. Ryan: Yeah, I’m, I have a couple social media accounts. I’m on Facebook and Instagram. I currently teach what’s your tag on Instagram?

Instagram is at Hashimoto’s Healer. Okay. And I currently am a professor and clinical [00:45:00] supervisor at Yoan University where I’m teaching students how to practice you know, functional medicine as we discussed and I do see patients there as well. And

Dr. Weitz: if they want to get ahold of you directly, what’s your website?  Phone number, contact? Yeah, my website’s,

Dr. Ryan: ha hashimoto’s healing.com. You can reach out to me through there or message me, you know, via social media.

Dr. Weitz: Great. And your books are available on Barnes and Noble, Amazon,

Dr. Ryan: et cetera,

Dr. Weitz: correct?

Dr. Ryan: Well, there, but books are published by Hay House. Actually just approached me, they’re gonna do an audio version of my first book, how To Heal Hashimoto’s.  We’re in the process of doing that right now. They were gonna clone my voice and have ai

Dr. Weitz: and you said, no way. Let’s bring on the real thing.

Dr. Ryan: Yeah, it was like, yeah, I dunno. We’re in discussions with that right now, so I will read the book happily. They wanna replace me with a robot, but yeah,

Dr. Weitz: that’s the world we live in.  That’s the world we live in. Does the [00:46:00] robot have Hashimoto’s?  Okay, thank you, mark.

Dr. Ryan:  My pleasure.

Dr. Weitz:  Great talking with you.

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Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcast or Spotify and give us a five star ratings and review.  As you may know, I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and wanna promote longevity, please call my Santa Monica White Sports Chiropractic and Nutrition office at 3 1 0 3 9 5 3 1 1 1 and we can set you up for a [00:47:00] consultation for functional medicine and I will talk to everybody next week.

Dr. Andrea McBeth discusses how Stool-derived Postbiotics can restore gut health with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

In this episode of the Rational Wellness Podcast, host Dr. Ben Weitz discusses postbiotics with Dr. Andrea McBeth, a naturopathic clinician and expert in functional gastroenterology and the microbiome. Dr. McBeth shares insights into her work with fecal microbial transplants and her development of the pheno-biotic supplement made from sterilized fecal matter. The conversation dives into the benefits of postbiotics for various gastrointestinal conditions and overall gut health, the complexities of bile acids and their roles in the body, and the emerging understanding of the microbiome’s impact on brain and immune function. Dr. McBeth also highlights the stringent criteria for selecting stool donors for her supplements and announces an innovative partnership for clinical trials to gather more data on the effectiveness of postbiotics.
00:29 Meet Dr. Andrea Mcbeth: Expert in Functional Gastroenterology
01:26 The Science and Benefits of Fecal Microbial Transplants
04:50 Exploring Bile Acids and Their Clinical Importance
10:02 Understanding Prebiotics, Probiotics, and Postbiotics
12:28 The Development and Benefits of Sterilized Postbiotic Products
14:36 The Apollo Wearable: Managing Stress and Improving Sleep
16:07 How Postbiotics Enhance Gut Health and Overall Wellbeing
28:01 The Role of the Microbiome in Immune Education
29:02 Postbiotics and Their Complementary Role
31:51 Clinical Trials and Data Collection
32:58 Dosage Recommendations and Usage
35:52 Probiotics vs. Fecal Microbiota Transplantation (FMT)
42:20 Misconceptions About the Gut Microbiome
48:19 Sourcing and Criteria for Donor Stool
50:04 Conclusion and Final Thoughts
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Dr. Andrea McBeth is the founder and CEO of Thaena, a pioneering microbiome therapeutics company. She has a Bachelor’s in Biochemistry, focusing on molecular biology, and a Doctorate in Naturopathic Medicine. Early in her career, Andrea directed her ND clinical practice toward functional GI disorders and autoimmunity, launching one of the first stool banks for fecal microbiota transplantation to treat Clostridioides difficile infections.  Driven by the interface between gut microbes and human health, Andrea invented ThaenaBiotic, the first human-derived postbiotic supplement. The website is Thaena.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

 

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me and let’s jump into the podcast. 

Today we’ll be speaking to Dr. Andrea Macbeth about postbiotics. Dr. Andrea Macbeth is a naturopathic clinician who has been focusing on functional gastroenterology and the microbiome since 2015. She became an expert at using fecal microbial transplants as a form of therapy, especially for c diff infections, and she started a stool bank.  She is now the founder and CEO of Thaena, Inc. And she has developed a breakthrough fecal-derived postbiotic nutritional supplement, phenobiotic, made from sterilized poop that enhances the health of the gut and overall health. And that will be a focus of our discussion today. So Dr. McBeth, thank you so much for joining us.

Dr. McBeth: Thank you so much for having me. It’s my pleasure to be here.

Dr. Weitz: Great. So tell us how you got involved with fecal microbial transplants.

Dr. McBeth: Yeah, I was, I like to joke, I’m a researcher, scientist that like fell out of academia, fell down the hill to become a naturopath. Okay. So I’m a naturopathic provider.  I was a molecular biochemist, kind of focused before that in my academic career.  I didn’t finish my PhD.  I left to focus on taking care of a family member who had cancer.  And then in that process found the journey and desire to do more preventative medicine, and so became a naturopathic provider.  Got really involved in the gastro, GI, autoimmune, kind of focused naturopathic community, right? And worked with a doc named Mark Davis, who sort of pioneered fecal transplants in Portland, Oregon in the early days when it was being introduced in Boston and other parts of the US healthcare system for the treatment of a disease called c diff.  So fecal transplant is what it sounds like. It’s the delivery of healthy donors stool to a recipient, and it’s super effective at treating an infectious GI bug called C Diff. And yeah I was really enamored with the microbiome. I found it fascinating. It was a great bridge for me between my old life as an academic and I, my understanding of why all these tools we use are so important.

Dr. Weitz: And my understanding is there’s emerging evidence of fecal microbial transplants being beneficial for ulcerative colitis and Crohn’s and maybe a bunch of other conditions. I’ve heard Dr. David Perlmutter talk about using it for neurological conditions.

Dr. McBeth: Yeah. So what is really cool and sort of unique is in medicine in particular in the US healthcare system, we normally start with a theory or that pharma starts with a theory, they create a drug and they test it in a disease.  And very rarely do we see something like fecal transplant that sort of works backwards. It’s an ancient therapy that’s mentioned in Chinese literature. It’s standard amendment. Of medicine and veterinary medicine and was reintroduced after being used in the fifties for this antibiotic resistant pathogen.  And what that did is challenge what we think we knew about the microbiome and open a doorway to clinical trials. Hundreds of [00:04:00] them for everything from liver disease, neuroinflammation, autism, Parkinson’s, immunotherapy responses, post bone marrow transplant, graft versus host disease. They use it…They looked at it in pediatric diseases. I mean, kind of anything you can imagine and in mice as well for basic science. And what it did is say. We have no idea how it works, but clearly the microbiome impacts the brain and the immune system and our metabolic system in ways we never even thought possible before.  And so it, it opened a whole, it challenged neurologists to rethink how they think about the gut in ways that I think functionally we do that. But it’s really cool to see that sort of adopted and challenged on a 10 year timeframe in the US.

Dr. Weitz: Cool. I noticed that among your studies, you spent some time studying bile acids.  And I’m just curious if you have any clinical pearls about bile specifically because it’s starting now to be an add-on to some of the stool tests. Diagnostic Solutions now has an add-on to measure bile acids and short chain fatty acids. And I’ve been thinking more about bile acids. I have a few patients with bile acid malabsorption and I, yeah.  I know that bile acids are one of the players, and I wonder if you have any thoughts about how clinicians can think about bile?

Dr. McBeth: Yeah, so again, similarly really interesting story. We thought bile acids. In traditional biology, there’s four of them, right? And they get conjugated and de conjugated, and it’s the cycle back and forth between the liver and the gut microbiome.  And they’re thought of as the, these four bile acids get used to excrete stuff, right? That’s sort of our traditional biology understanding in a really simplified way. But it turns out that with the [00:06:00] microbiome research, there are thousands of versions of bile acids and. Different bacteria can conjugate different molecules to bile acids.  And what we are now starting to appreciate is that bile acids aren’t just this thing that helps us excrete fat. It’s actually a signaling transporter molecule that brings, in theory, nutrients are small molecules to all different parts of our body. And they’re the really interesting researcher at UCSD in San Diego named Peter Dorsen.  And all he does is study bile acids from the perspective of how microbiome bacteria make them. And he uses mass spec to sort of look at the molecules. And then he has done really interesting work tracking where they go in a mouse, for example.  And there are specific bile acids that go just to the frontal lobe or the cortex of the mouse brain, and they have very specific [00:07:00] conjugates with them.

And so what we are now starting to think about when we think about bile acids is that they actually may be important nail male delivery systems for nutrients to distal tissues and. Adding complexity to the importance of the microbiome in our bile, but also just emphasizing how crucial having these core functions working.  Because if we, I mean, I think about people who get their gallbladder and appendix removed a lot, right? And I understand that saves people’s lives sometimes, but the cost of that. When we start to think about what happens when people lose functionality of making these foundational transporter molecules is probably more far reaching than we appreciated.  And when you see patients with bile acid malabsorption or [00:08:00] other dysbiotic associated issues with this. You know, I just am reminded that it’s such a critical orchestra–mouth to anus–with our vagus nerve and how central appropriate functionality of our nervous system and expression of all these, whether it’s digestive enzymes, or bile acids or pancreatic enzymes.  They impact the environment and then having a healthy microbiome is central to being able to take those things and redistribute and put them in the places they need to be. That’s probably more than you wanted about bile acids, but I just think no I, it’s so fascinating.

Dr. Weitz: I’m trying to figure out how to think about bile acids and what seeing bile acids come up on a stool test means and what role that’s playing in patients.  Is it, you know, when a patient has like breakthrough diarrhea, is that a bile thing?  How do you know, and you know…

Dr. McBeth: I think we know a lot less than we think we do, but the patterns are important and I wouldn’t negate the importance of having, if, you know people’s bile acids are out of whack, right. That is potentially impacting their brain, for example.  And so it is something we should pay attention to and make sure it’s hard to know what is health, right? We still don’t actually have a good definition of a lot of these biomarkers and stool testing even. But what we do know is if it is out of balance and it is out of whack, it has far region consequences.  And so doing what we can to sort of re equilibrate probably has benefit and. I don’t know the right answer of how to do that, but we have pretty good tools for bile acid malabsorption and nervous system patterning. And you know, those people that you see that just everything’s outta whack ’cause they’re in fight or flight versus people that have just one thing wrong.

Dr. Weitz: So I, I mentioned post biotic. I’m wondering for helping listeners understand what we’re talking about. Could you maybe give us a brief definition of what a prebiotic, a probiotic, and a postbiotic are?

Dr. McBeth: Yeah, so I, I caveat this with, there’s scientific definitions that are sort of like firm in the sand.  And then there’s marketing definitions that we’ve developed to help people understand things and or supplement companies have developed to help sell things.  And prebiotics and probiotics and postbiotics are definitely the latter.  They’re marketing terms, I think, more than scientific terms. And there isn’t true consensus on what they mean.  There is a organization called ISAP that has defined a probiotic to be a. Studied strain of bacteria that’s been shown in clinical trials to have health benefits. But we all think about probiotics as like all the good bacteria that come on fermented foods. And even some of the time we think about just the good gut bugs we have in our gut as probiotics, right?  The live material. And I think it’s fair to just put all probiotics into the. A live bug that can live in our gut and or on our skin or in our ecosystem of our body and provides benefit. And that’s loosely my definition. Okay. And that helps anchor what a prebiotic and a prebiotic is.

And a prebiotic is the food or nutrients or something that bug metabolizes or eats.  Then the thing that it produces when it eats that prebiotic is a post biotic. And I think of it as like a broccoli comes in, it gets digested. We have good bugs in our gut. They, those probiotics break down that broccoli into a post biotic, which may be butyrate, for example.

Dr. Weitz:  Right. Short chain fatty [00:12:00] acids that are produced by the bacteria in our gut.

Dr. McBeth: Yeah.  And the Isop definition is a little different and sometimes people call, you know, the lactobacillus you buy at the grocery store that’s been heat killed a post biotic. I think the most clear definition and the way that I like to think of it is it’s the thing that the probiotics make and it’s not alive.  It’s a small molecule or the dead parts after it’s been heat killed.

Dr. Weitz: Right. So why did you de decide to sterilize the poop in making your post biotic product?

Dr. McBeth: Yeah, so fecal transplant had all this early research, it’s like 90 plus percent effective at treating c diff. It was really cool to work with, right?  And I really loved having patients come in and have a tool that I knew could turn them from, you know, in and out of the hospital or really acutely ill to. Totally better in 24 hours. It’s like one of the coolest things I’ve [00:13:00] ever worked with. I love all of the naturopathic stuff, but fecal transplant was really cool.

Dr. Weitz: And by addition, how are most fecal transplants done these days

Dr. McBeth: either oral capsule, there’s two companies that made pharmaceutical versions. So there’s an oral capsule company and there’s an enema or like colonoscopy delivery version. Okay. And they both work, which is cool. And so we were working with it and the barrier was infectious disease risk.  We don’t know what we don’t know, and COVID came along just like other things of, in the history of using, you know, blood is a good analogy, right? Like blood donation, we can’t make synthetic blood. It’s too complicated. The same thing’s true for poop and. But you don’t know what you don’t know with blood.  And so the HIV epidemic really changed the way the regulators thought about human derived products for [00:14:00] good reason, right? And so when stool came along, they were concerned about the same kind of hypothetical, and then COVID happened and it was like, well, we don’t know if COVID could be in the stool and if it can be transmitted that way.  And so we had already been thinking about looking at a sterilized version of. FMT and that sort of was the catalyst to get there to say, okay, well we don’t have a way to test for infectious disease, so let’s just heat kill it, know it’s good, and then have a sterile version from there. And that actually ended up being really beneficial and working.

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Dr. Weitz: I’ve really been enjoying this discussion, but I just want to take a few minutes to tell you about a product that I’m very excited about. Imagine a device that can help you manage stress. Improve your sleep and boost your focus all without any effort on your part. The Apollo wearable is designed to just to do just that, created by neuroscientists and physicians.  This innovative device used as gentle vibrations to activate your parasympathetic nervous system, helping you feel calmer, more focused, and better rested. Among the compelling reasons to use the Apollo wearable are that users experience a 40% reduction in stress and anxiety. Patients feel that they can sleep.  Their sleep improves up to additional 30 minutes of sleep per night. It helps you to boost your focus and concentration and it’s scientifically backed. And the best part is you can get all these benefits with a special $40 discount by using the promo code weitz, W-E-I-T-Z, my last name at checkout to enjoy these savings.  So go to Apollo Neuro and use the promo code Weitz today. And now back to our discussion.

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Dr. Weitz:  Let’s talk about your product and what kinds of benefits can be derived from this post biotic sterilized poop. And how it can promote health and improve the microbiome and what other benefits?

Dr. McBeth: Yeah, so it, it has a bunch of short chain fatty acids, like we mentioned bile acids.  The magic is probably in a lot of, a little bit of, a little bit of a lot of things. So tens of thousands of small molecules that go into it. And we think they’re working synergistically to bind immune receptors, modulate the oxidative stress of the gut. We know now that there’s little neuronal cells that stick into our gut and these small molecules bind them and trigger responses that mediate our brain.

Dr. Weitz: Yeah, I saw where you wrote something about those neuronal cells. What are those called?

Dr. McBeth: Neuropod cells. I love em. Oh yeah. Terrine that. Okay.

Dr. Weitz: That’s fascinating. I’d never heard of that before.

Dr. McBeth: We just like just discovered them. Right? Like science just discovered that there’s neuronal cells sticking into the microbiome Miu like 10 years ago.

Dr. Weitz: Wow.

Dr. McBeth: I know. And they can trace ’em. So they do this cool stuff and. Neurobiology where they use a rabies virus that has a green floor for on it. So it’s like neon green and you can inject it into a nerve like in the gut. And the way the rabies virus is it transmits and travels back to the brain. And so you can actually trace a nerve from the gut back to the part of the brain that it’s connected to.  And they do this in mice and rats, and they can see these neuro pod cells are going to all different parts of our brain.

Dr. Weitz: So these nerve cells are like receptors.

Dr. McBeth: They’re activated by like calcium channel receptors. And these postbiotics are what? Like turn the light switch on. Turn the [00:18:00] light signal on.

Dr. Weitz: Really? Wow. Are those playing a role in motility?

Dr. McBeth: Yeah, they’re playing a role in how we make decisions in our prefrontal cortex and wow, how our nervous system is patterned. And you know, really, it really goes a long way to challenge like, who’s in charge here?

Dr. Weitz: So it maybe sort of helps explain things that we’ve been saying.  Oh, well, it’s because of the vagal nerve. And it may be really the neuro pods that, you know, we’re seeing some of these benefits of probiotics and gut bacteria. Definitely careful akkermansia affecting blood sugar and maybe through these neuro pots

Dr. McBeth: partly. And then the other place that. This is really interesting is, you know, our gut microbiome and our liver are constantly communicating.  We have this really tight SAS link between the liver and a lot of that [00:19:00] metabolic impact that we see from like pendulum and amania and even bile acids can go to the liver. Educate T cells there, or impact our insulin or our ghrelin. I mean, even, I think just the fact that GLP one now with Ozempic and all this, we are familiar with the concept of a GLP one agonist.  GLP one agonist drugs are just a longer life version of what we naturally make in the gut from these receptor. Relationships. So our gut’s constantly making GLP one, but like on an hourly basis from tryptophan binding receptors or bile acids, binding receptors. And then our gut cells are enteric. Colon lining is making GLP one.  So there’s all kinds of stuff going on there that Wow. Kind of at like the very tip of the iceberg on understanding.

Dr. Weitz: So what kinds of GI conditions can these [00:20:00] postbiotics that the antibiotic help, is it beneficial for sibo, I-B-S-I-B-D, et cetera?

Dr. McBeth: Yeah, so we, we have the luck and the curse of being the first people to use this, right?  And like completely new to the market, right? And. Part of the advantage of that is so obviously

Dr. Weitz: there’s no randomized control trials, right. With thousands of patients. Right? Right,

Dr. McBeth: right. And so what we’re doing is piggybacking off theory from work that’s been done in small molecules like butyrate and sine and stuff.  But our product is in smaller concentrations, and so we’re not a hundred percent sure. And then we have all this fecal transplant data. We think there’s some parallel to that mechanistically, and then we’ve been using it clinically for several years and we have observational anecdotes that show it’s really great if your gut is like moving too slow or too fast, right?

What’s interesting is it can [00:21:00] help with people who are having too many bowel movements, but it also can help with people that haven’t had bowel movements and increased motility in like a couple days. It works in a way that seems to be like a buffer, like a pH buffer, right? Like so whatever direction you’re out of balance from SIBO or whatever, it brings you back to that homeostasis probably because it’s 14,000 different molecules and whatever.  You’re out of balance and it’s sort of nudging you back to that center.

Dr. Weitz: Have you started trying to figure out exactly what the composition is with all these different molecules?

Dr. McBeth: Yeah, we actually bought a mass spec like two days ago. Okay. From an auction. It’s like a very fancy piece of equipment to look at ’em.  We’ve like paid other people to do it before, you know? Right. But I think of it as like the new gold rush. Like really there’s so many important molecules in our poop and nobody has, like, we just haven’t looked [00:22:00] for it before. Right. So we have run a lot of metabolomics. I have like Excel sheets of lists of stuff.  And I put it into chat JBT and ask it to tell me what it thinks. And we’re sort of at this very early stage of exploration, but we have a, we have an r and d arm of the company that will work on kind of parsing out what is doing what, if we can, you know, there’s a lot there, but. I think it’s the future.

I, so here’s another anecdote I like to use is traditional pharmaceuticals in our medicine. We’ve like traveled to the jungles and looked at the bottom of the ocean and we’ve, like, we’ve skipped, we’ve looked all over the world for molecules, right? That do something. And a lot of our really important medicines come from plants and places, but.  We have been co-evolving with these molecules in our gut since the beginning of time, so they don’t [00:23:00] have acute toxicity, but they still functionally do really important jobs. And so if we can start to understand what postbiotics are, the ones that hit that nerve, that tells me to chill, you know, to not have anxiety, I think we’re gonna have a lot better tools to help people in the future from this gut.

Dr. Weitz: I watched a YouTube video where you were talking about the postbiotics potentially being beneficial in reducing visceral hypersensitivity, which is something that we often see in IBS patients. Can you talk about that?

Dr. McBeth: Yeah. So, we. I mean, the visceral hypersensitive is really cool, right? Like what we are learning about it and the way that our nervous system patterning Well,

Dr. Weitz: it’s really, I think, common and often, maybe over often overlooked and yeah, not really sure how to address it.  We use curcumin, we try different things, but [00:24:00]

Dr. McBeth: yeah, and it’s like imagine that the fire alarm has just been going off and that patterning has gotten reinforced so much that. You know, the underlying mechanism probably is a combination of oxidative stress and inflammation based on some basic science. Okay.  And nervous system patterning. Right. But the reason we think this might be helpful for that is it kind of lays a blanket over that fire in a different way than just maybe like curcumin does. Right. It turns down that signaling through this sort of multimodal interface of oxidative stress and immune and nervous system, like those neuro pod cells are cool, right?  Because they can bind and send a signal and tell us to chill. But if you don’t have receptors and it. Is a sad neuro pod cell because you’ve had malnutrition or malabsorption or you know, chronic IBS or whatever reason, antibiotics, a [00:25:00] lifetime of preservatives and just whatever that neuro pod cell, maybe it doesn’t work all the way.

Or like the little mitochondria that bring the calcium to turn on that switch doesn’t are sad, right? Our MIT mitochondria gets sad because we’re sort of poisoned, right? So if we can repair that by putting in the nutrients that a healthy microbiome represents from a healthy person, we can start to repair that damage and rebuild that mitochondria.  We did preliminary early work in a model system, a little like worm, and what was really interesting is the antibiotic. Impacts a lot of mitochondrial genes and oxidative stress genes, though it’s sort of like the housekeeper of turning on that like baseline rest and repair that we lose when we see hypersensitivity or chronic dysbiosis.  However you wanna kind of define. [00:26:00] 

Dr. Weitz:  So are, define that, are these neuro pods part of the mucosal lining? Yeah. Are they involved with leaky gut in some way?

Dr. McBeth: I mean, I think. I mean the, one of the things I’ve thought about doing just for fun is like teaching a class on all the different types of cells that line our gut because we’re learning new ones all the time in the same way we like know very little about the microbiome itself.  You know, our human cellular biology is really complicated and in you imagine the bottom of the VI is this stem cell, right? And the stem cell can turn into a goblet cell, it can turn into a neuro pod cell, it can turn into a regular like endothelial cell. It can turn into, there’s all kinds of things that can like turn into, and then you get this lining.  And the amount of goblet cells that make mucus versus the amount of immune cells that are coming in. Dendritic cells versus the amount of neuro pod cells is all variable depending on the environment and how that set [00:27:00] that stem cell kind of core growth comes. And I just think. Well, so some of the best preliminary research I’ve seen is looking at goblet cells in our mucus layer and goblet cells.  You have to have enough of them to make the mucus and then you have to have your vagus nerve telling them to make mucus to have a healthy gut lining. And the same thing’s probably true. I don’t know as much about the enteric endocrine cells or haven’t read about their maturation the same way, but the all of this biology is kind of has that core.  We need the cells, we need enough of them and we need the signals to turn them on to be effective.

Dr. Weitz: And do these postbiotics enhance the gut immune system?

Dr. McBeth: Right? Yeah. So the axis I think about is the neuronal. We know gut brainin is like super strong, the gut immune cells. That’s why so many immune cells are.  [00:28:00] Are focused in the gut, right? The pyres patch lives there because so much of our immune education comes from the microbiome. And the microbiome is really like our first. Interface to the environment to tell us how to be responding. It’s one of its core functions as an organ really is adapting and telling us what’s going on in the world outside of us.  And then it, the third arm is the metabolic arm. So how we respond with insulin and process energy and fast and get satiety and all that stuff. And on the immune side. So much of us are walking around with like, again, a different kind of fire alarm of inflammatory cytokines and overregulated towards, you know, TH one or TH two.  And what we really need is the T regulatory calm down signals. And it turns out that the microbiome is really central into turning those on and these [00:29:00] postbiotics in particular

Dr. Weitz: interesting. So right now a lot of us are using immunoglobulins as part of our treatment protocols. How we using this post biotic, interact with that?

Dr. McBeth: It compliments it. It’s a really good tool to add with IgG. I think it’s a really good tool to add with glutamine or nutrient powders or. Antimicrobials. It’s a good compliment for SIBO treatments. It’s a good compliment for mold and Lyme treatments, right? Because you’re repairing some of the die off or the kill.  The other thing I really like it with is N-acetylcysteine. ’cause N-acetylcysteine is sort of a detox and a biofilm disruptor, and this is complimenting that as well.

Dr. Weitz: So for those of us who have different phases of care, is there one phase of care that this would be better for or,

Dr. McBeth: yeah, towards like the end of the kill and toward [00:30:00] into the repair.  Okay. Like it’s very much a part of the repair and tolerance and right support phase. Right. And I also just say, now it makes sense. It tends to help people like the sicker they are, the more likely it is to benefit them, like the more screwed up their gut is. 

Dr. Weitz:  Right now there’s one of these immune products that we use partially because it’s been shown to bind some of the endotoxins.  I wonder if that’s something that this product does as well.

Dr. McBeth: I don’t think it’s overtly binding. I mean. Some of the classes of things we know this product is doing is it is, it does have anti-microbial properties, it does have bacteria sins and Okay. Things that would be, you think about all the different things microbes make to modulate their environment.  And so they’re making anti what we call bacteria sins, which are kind of like their own [00:31:00] antibiotics to compete against their neighbors. They’re an making antifungals to create, to like fight against their fungal neighbors. And then they’re making antivirals.

Dr. Weitz: Right. And you have bacterial phages from the viruses in the gut, right?

Dr. McBeth: Yeah. And then, you know, so there’s an a component of this that’s like anti. Specific things that the healthy gut didn’t want or was trying to compete. And then there’s a bunch of nutrients there. And I think of it kind of as like the loss micronutrient vitamins, like the bile acids or the brain that I can’t make.  ’cause I was a C-section baby and I have so many antibiotics at my life and I’m on. I have autoimmune disease and all these things, right. So like I probably don’t make the special prefrontal anti-anxiety, but

Dr. Weitz: Interesting. So do you have research currently underway on this product?

Dr. McBeth: Yeah, and I would, I mean, this is the first time I’ve done a podcast where I get a.[00:32:00]  Announce. We have this really cool partnership with a clinical trial company called People Science. And they ran decentralized clinical trials for pharma for a long time, and then they pivoted to the supplement space. And so we now, anybody can go to our website@thena.com and buy the product and anybody can.  Sign up for the Chloe app, which people science built and opt in to share their data. And it’s really just a way for us to collect all this anecdotal data in a meaningful way. Like, did you poop today? Did you take your, the antibiotic? How was your anxiety? How was your diarrhea, constipation, or whatever it is that you are sort of co-managing.  The app is gonna give us. Hopefully a few hundred people to really say, this is what we should do an RCT on a clinical trial.

Dr. Weitz: Right? Sure. Randomized clinical trial. So what is the [00:33:00] dosage that usually recommend?

Dr. McBeth: Yeah, the dosage is,

Dr. Weitz: and are there are different strengths or is it just one strength or?

Dr. McBeth: It’s just one strength at a hundred milligrams, and you can either buy a sample pack to see if it helps a seven cap pack. There’s a 30 bottle, 30 cap bottle, which I recommend generally for people as a one month, roughly one cap a day, and then there’s a 90 cap bottle for people just as the most cost, cost effective, but for dosing.  One CAPA day is our base recommendation, but it’s unique in that you can kind of use it when you need it or use it when you’re outta sorts, and you can taper up on it and you can just. You could use like four caps a day and then not any, so you don’t have to taper off of it. We recommend people start with one cap and then add another and go up if they’re gonna increase dosing, but you don’t have to worry about weaning off of it.  And it can be really great for acute [00:34:00] GI stuff and you can just decide to use it when you want to eat cheese because cheese doesn’t agree with you. But this kind of like. Gives you a break, right? Or

Dr. Weitz: anything? Is there best time of day to take it? Is it better with meals? Apart from meals?

Dr. McBeth: I think with meals in the evening is my general baseline recommendation, but again, there’s not, it’s.  We see very few side effects. So pe if people wanna take it in the morning and it’s easier for them and they don’t eat breakfast, totally fine. Are based there certain

Dr. Weitz: supplements you shouldn’t take it with.

Dr. McBeth: Not that we have found. I mean, I’d say the only place to be cautious is it does seem to turn on that orchestra, right?  Motility, stomach acid, pancreatic. And this is anecdotal, but if you’re taking a whole bunch of beane HCL digestive enzymes, I would just be cautious to not take too much. ’cause it might turn back on your stomach [00:35:00] acid. So, you know, use this as a tool to kind of wean one way or the other. If you are on a bunch of stomach acid, just kind of pay attention.

Dr. Weitz: Right. Are there any contraindications.

Dr. McBeth: No, I mean, stomach acid is the one that in the early days, people theoretically were concerned about. We haven’t really had adverse event reporting. Sometimes it does help heart like acid, but the only. I mean, again, it seems to help people that are out of sorts, right?  And then it, or if it does nothing, it’s worth trying a sample pack to see. It can help you with your bowel movements in 24 hours. So you should know if it’s gonna help you,

Dr. Weitz: Pretty quick. Do we know how f and t works? No. Okay. So. Once again, [00:36:00] the thought with probiotics and of course FMT, is that we have this damaged microbiome, and now we’re gonna, you know, basically reseed our guts with a new microbiome.  You know, we’re laying down sod and now we have a new beautiful lawn. But perhaps that’s not what’s happening. And I noticed in one of your, one of the articles you talked about how. We’ve learned that in some cases dead probiotics are as effective or even more effective than live probiotics.

Dr. McBeth: Yeah, we spent a lot of money, or like the industry spent a lot of money on marketing to say, probiotics need to be alive.  And our, the fanciest marketing was like the most CFUs of live bacteria and the best way to get it, and turns out that they just don’t en graft. That’s not how the biology works.

Dr. Weitz: So they’re basically [00:37:00] probiotics and maybe even FMT is. Do we think FMT is different? Does it reason there’s some take hold in your microbiome?

Dr. McBeth: There’s some evidence that fecal transplant and grafts, and that’s probably a component, especially in really sick people, right? So if you have an ecosystem microbiome that’s super healthy, you’re, nothing’s gonna eng graft, nothing’s gonna outcompete the guys that you already have there. But if you’re really sick, you have c diff, you took a bunch of antibiotics, you do have room for something else to come in.

Probably and in fecal transplant they see some, but there’s a washout period like fecal transplant. You do it, you feel better, but it’ll go kind of rebound back to your previous in six months to a year, you know? So I think it depends on, we all have a set point of our immune system that we. We established a set point with our [00:38:00] microbiome, like by the age of three, and our immune system similar to our metabolic set point.

It’s really hard to change that for any reason. You know, taking your appendix out would impact it. But taking antibiotics, you know, we’re all always gonna come back to that homeostasis. And so you can get yourself out of an acute dysbiosis or acute bad space, but you’re. You are not gonna be able to out engineer that set point very easily without really concerted effort of continuous dietary changes or, you know, input from something like a, the antibiotic.

And that’s part of the reason fecal transplant I think has not been, I think fecal transplant would’ve done better in conventional medicine in terms of. Applications and other diseases if it had been dosed more because c diff is a very specific [00:39:00] circumstance that’s different than most of the chronic diseases we deal with.

Dr. Weitz: Right. I think you mentioned that this could be used in cases of a flare. Like what about a patient, like with Crohn’s who’s having an acute flare? Is this something that you would think by itself or in combination could be beneficial?

Dr. McBeth: We don’t have any clinical research on IBD, but there’s research in fecal transplant that’s really strong for ulcerative colitis.  That’s interesting. I don’t think we’re gonna replace conventional treatment, but I think it’s a great tool for a flare and a compliment. And I actually think if antibiotics gonna help people, you’re more likely to help somebody when they’re in an acute phase rather than their baseline. And so without, you know, going too far into saying we know something we don’t.  Anecdotally it seems to support people in a flare. And I would love [00:40:00] to see more research looking at. Role because I think, again, where fecal transplant fell short was the way that they were dosing it in a lot of these IBD clinical studies. And that’s where it got like some preliminary good data, but the metadata is not great.  And I think just the clinical design, it’s weren’t very good.

Dr. Weitz: Yeah. And this

Dr. McBeth: is way safer because it’s failed.

Dr. Weitz: Right. Do you know Dr. Rebar? He’s a in integrative gastroenterologist in Los Angeles. And he does a lot of scoping and stuff like that. You should probably talk to him. He might be interested in maybe even getting involved in some of the research.

Dr. McBeth: Yeah, we have a collaboration with, a group at Vanderbilt looking at it and people who have had colectomy, so their whole or portions of colons or pouchitis, you know, where stuff that’s really hard and it’s just observational, they’re introducing it with their other stuff. But it makes total sense [00:41:00] that it would help people that are missing a colon.  Right, right. Because that’s like the whole thing. Yeah, is all these small molecules are made in a healthy ecosystem.

Dr. Weitz: I’ve always been amazed at that whole concept. You know, we, there’s just unbelievable amount of research on the benefits of the microbiome, and now basically you’re taking patients who don’t have any colon and you’re taking a huge part of their microbiome and it’s just not there.  And yet. There’s a fair amount of ’em that continue to thrive and do reasonably well for long periods of time.

Dr. McBeth: I mean, the human body is very resilient. We’ve seen anything, you

Dr. Weitz: wonder if it’s creating a new microbiome out of the small intestine. Yeah. Elsewhere.

Dr. McBeth: I mean, I’m sure if, and again, they we’re just like, haven’t done a lot of research into this, but like.  We know so little. Yeah. And the amount of sampling we’ve done and what we’ve looked at with taxonomic [00:42:00] sequencing, like and lacking functional information from that data. I mean, I wouldn’t be surprised if the small intestine microbiome is way more important than we think it is. You know? And compensatory too for when we have issues with the colon.

Dr. Weitz: Yeah. Are there some misconceptions about the gut microbiome that you think need to be corrected?

Dr. McBeth: The microbiome is used in marketing, and I am guilty of this too, right? Because I have a supplement company and I market shit literally okay. On the internet. But I just really wanna caution that we know so little.  It’s an organ we right. We only discovered it 20 years ago, and it’s not like our brain or our heart that you can see when you cut the body open. It’s literally been invisible, and so it’s [00:43:00] also. What makes us individually resilient? I love it because it’s a very empowering paradigm to introduce to patients and providers because each person has the ability to adapt in our individual and everything we think we know about standards.  Right. And algorithm medicine. This is where it diverts. And this is why some people respond to some things and some people respond to others. And so we know nothing except that we know we’re all special and unique. And you have to be your own scientist in everything you’re approaching, whether it’s herbs or diet or supplements or whatever.  And I really like that. That’s. A way for us to frame that individuality without making people feel crazy. ’cause they’re like, you know what? It’s like, why doesn’t this thing that worked for everybody else work for me?

Dr. Weitz: So let’s say you are a [00:44:00] clinician and you decide to use the antibiotic on a patient who’s maybe got IBD and is having an acute flare.  What would you think would be. A reasonable dosage that if you wanted to push it a little bit, that you could go up to?

Dr. McBeth: Yeah. I mean, so one capsule is loosely equivalent to a half a gram of pooled stool, but a half a gram of stool.

Dr. Weitz: If they threw an FMT, how much stool are you getting?

Dr. McBeth: 50 grams, 25 gram to 50 grams.  

Dr. Weitz: Wow. Okay. So that would be a hundred capsules, right?

Dr. McBeth: And I think part of the reason I really like the antibiotic and I liked making it, is it’s very much a low dose, very safe, gentle nudge. I think it’s totally fine to, to taper up patients in acute phase. I had food poisoning yesterday and I just like pop a handful kinda.  Okay. But I’ve been doing that for a long time. Right. And I’m [00:45:00] comfortable with that. But starting with one and then going to like two, twice a day, you know, or up to. Two, three times a day. I don’t think you need a lot more. You definitely don’t need a hundred or 30 or whatever. I don’t think it’s gonna hurt you, but I just don’t think it’s necessary and it’s not cost effective.

But I, again, individual people, it’s reasonable to sort of test out that tapering up and down and sort of see where in acute phase people respond, verse. At a baseline, kind of a maintenance or you know, honestly, what’s interesting and we didn’t expect is sometimes this really helps people, but then it kind of like the effect of it kind of tapers off and it actually works better if you post dose it.  So you give people whatever they tolerate, two, four caps a day for three or four days, and then you wait a week and then you do it again. And so everybody’s a little bit different there too. [00:46:00]

Dr. Weitz: Interesting.

Dr. McBeth: Don’t ask me why we know nothing fascinating. It shouldn’t do anything. Right. Yeah. That was what I was told when I first started this, but it definitely seems to be a safe tool, a gentle tool to help people when they’re in a tough spot and other things don’t seem to be working.

Dr. Weitz: Right. Is there any smell or taste?

Dr. McBeth: I don’t think so. There’s like a, maybe a musky undertone. Okay. It’s not poopy. Right. Like we actually have just finished doing a very. Diligent, we’re gonna put like a desiccant pack that’s very non-toxic and very, you know, top of the line that has like a little bit of citrus or mint.  We’re deciding between those two just because it’s an IIC factor. People and you know, the other thing I tell people is if you’re anxious, you don’t know if you should take this. You’re uncertain. Don’t just don’t do it right. Don’t do it. Be, I like, we all have agency, so don’t be peer pressured, but.[00:47:00]  You know, email me and I’ll send you why I think it’s safe, if you want that information.

Dr. Weitz: Where can practitioners or patients find out about ordering it?

Dr. McBeth: Yeah, so we have a website thena.com. And

Dr. Weitz: can you spell Thaena?

Dr. McBeth: T-H-A-E-N-A. So it’s the Greek spelling.

Dr. Weitz: Oh, it’s the Greek spelling.

Dr. McBeth: Okay.  Yeah. ’cause microbes, and, you know. The domain was available if you spell it funny, you know. And yeah, and then we sell it through our website. And so there’s a provider wholesale cost, so I recommend definitely if you’re a provider, sign up, it’s half price, wholesale. And then direct to consumer. A 30 cap is 1 99.  And a 90 cap is 4 99. But also if you’re a patient of a provider, you get a URL and you get a discount. If you sign up for data tracking with our Chloe app and contribute, you get 30% off. So we have lots of ways to incentivize and try to make it accessible, but still maintain the integrity of the science and the sourcing because, you know, these are really healthy people.  They’re hard to find. It’s not simple to find a vaginally born, breastfed, fully organic. Never been sick. 

Dr. Weitz: Oh wait, you know, I don’t think we really explained that. So the patients that are donating the stool have to meet certain criteria.

Dr. McBeth: Yeah. Our super poopers, we’ve been recruiting them for poopers a long time.

Dr. Weitz: Okay. Okay. So go through real quickly what exactly characteristics they have to meet for their poop to qualify.

Dr. McBeth: Yeah, so they’re, they’ve never been chronically ill, they’ve never been prescribed, you know, Adderall or antidepressants or heart disease medicine, or, you know, they’ve never had cancer, they’ve never had autoimmune disease.  They’ve never really been sick besides like the flu or acute stuff. That’s normal. They’ve had [00:49:00] less than five antibiotics in rounds in their lifetime. They were vaginally born, breastfed. We do a very exhaustive interview about their environmental risks. We talk to them about what their job was and how they grew up and what food they ate as kids and did they have pets and you know, everything we can think of that we know about the microbiome.  And then we have them do a diet diary and we look at their food and we really care that they have good quality ingredients and not ultra processed foods, that they’re healthy in exercise. And their BMI is in a good range and they’ve never yo-yo dieted and they have a good relationship with food and they’re not allergic to anything.  And then we do theorem and stool testing for infectious disease and we back check them on, you know, all the important things.

Dr. Weitz: Wow. So this is good poop.

Dr. McBeth: Yeah. I mean, as good as you can get in America in 2025.

Dr. Weitz: Alright. Thank you so much for joining us today.

Dr. McBeth: Yeah. Thank you for having me. It was lovely.

____________________________________________________________________________________________________________________________________

Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcast or Spotify and give us a five star ratings and review. As you may know. I continue to accept a limited number of new patients per month for functional medicine.  If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and wanna promote longevity. Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Dr. Nasha Winters discusses The Metabolic Theory of Cancer with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

In this episode of the Rational Wellness Podcast, hosted by Dr. Ben Weitz, the guest is Dr. Nasha Winters, a naturopathic doctor and integrative oncology specialist. The discussion centers around the integrative approach to cancer, including Dr. Winters’ personal journey with ovarian cancer and her insights on the metabolic theory of cancer as opposed to the somatic mutation theory. They explore various factors influencing cancer, such as diet, environmental toxins, and mental health. Dr. Winters also shares information on innovative diagnostic tools, the importance of metabolic health, and her work in educating the public and healthcare providers. The conversation emphasizes that individual treatments should be tailored to the patient’s unique metabolic and epigenetic profile.
00:26 Guest Introduction: Dr. Nasha Winters
01:55 Current State of Cancer Worldwide
03:56 Historical Context of Cancer and Health
12:07 Advancements in Cancer Diagnostics
20:30 Dr. Nasha Winters’ Personal Health Journey
29:28 The Metabolic Theory of Cancer
36:24 Reevaluating Cancer Theories
38:20 Metabolic Approach to Cancer
39:08 Impact of Diet and Environment
40:23 Microbiome and Immune System
42:37 Radiation and Metabolic Health
52:12 Supplements and Immune Support
59:00 Personalized Cancer Treatment
01:07:10 Integrative Oncology and Future Directions
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Dr. Nasha Winters is a licensed Naturopathic Doctor and an Integrative oncology specialist.  She is the host of the Metabolic Matters podcast and Executive Director of the nonprofit organization, the Metabolic Terrain Institute of Health.  And she is also a cancer survivor herself.  Dr. Winters has a vision to open a residential integrative oncology hospital and research institute and she recently opened a metabolic research lab. She offers the Terrain Advocate program and the Metabolic Approach to Cancer practitioner master course. Dr. Nasha is a co-author of the best-selling books “The Metabolic Approach to Cancer” and Mistletoe and the Emerging Future of Integrative Oncology.  Her website is DrNasha.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 

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Podcast Transcript

Dr. Weitz: Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.

The Topic for today is an integrative Approach to Cancer with Dr. Nasha Winters. Dr. Nasha Winters is a licensed naturopathic doctor and an integrative oncology specialist. She’s host of the Metabolic Matters podcast, executive director of the nonprofit organization, the Metabolic Terrain Institute of Health.  She’s also a cancer survivor herself. She has a vision to open a residential. She’s working on opening a residential integrative oncology hospital and research institute, and she recently opened a metabolic research lab. She offers the Terrain Advocate Program and the metabolic approach to cancer practitioner master courses.  Dr. Nasha is the co-author of the bestselling books, the Metabolic Approach to Cancer, which is one of the few books we have all sorts of highlights and tear backs. Your book and Lisa Alschuler’s book in the cancer realm are the two books you have to have and also the Missiletoe book. In the emerging future of integrative oncology, Dr. Nasha is on a mission to educate and empower the nearly 50% of the population expected to have cancer in their lifetime, and prevention is the only cure. Thank you so much for joining us.

Dr. Winters:  It is an absolute honor to be back with you, Ben. Thank you so much.

Dr. Weitz:  Absolutely. So before I ask you about your personal journey with cancer and we dive into the metabolic theory of cancer and your approach to managing the terrain for cancer, I want to ask you, where are we in the nationwide, or perhaps worldwide… (I don’t know why we limit ourselves to our nation) fight against cancer? While cancer mortality continues to decrease, cancer incidence has not really decreased that much and there’s been an significant increase in certain types of cancer in young people. So what do you think is going on?

Dr. Winters: Wow, such a great launch into this conversation.  So we actually just got an update on the statistics, the World Health Organization statistics on cancer. And so just for your listeners to know,

Dr. Weitz:  oh, World Health Organization, that’s fake news…

Dr. Winters:  I know. Maybe we won’t totally trust that it’s pretty compelling information and that today in the United States alone, 1700 people will die of cancer just today.  Wow. Okay. Globally, 26,000 people will die of cancer today. Wow. Wow. That’s a lot. That’s a lot. That’s talk about a, an epidemic, right? Like that’s a big one. A hundred percent. Exactly. We also now, you know, really it has driven home that 50% of us, as you mentioned, we might be living longer with cancer, but we are certainly meeting the diagnosis more often.  And now one of two of us are expected to meet this diagnosis in our lifetime. And then to your point, we’ve had a 36%. increase in cancer diagnoses under the age of 40. And in, you know, peer reviewed journals such as nature and whatnot, they’re scratching their heads and saying, gosh, I don’t know why.  Maybe it’s something genetic, which I’m just sit there and think to myself, are we still having that conversation?

Dr. Weitz:  Massive change in our genes in the last 10 years…

Dr. Winters:  My goodness gracious. So it’s like we just, we are, you know, we look at this like process. So I think how I look at it is this didn’t happen overnight.  Right? So, you know, you and I think have had this conversation before, and I want to give a little context to your listeners that when we think about the world, you know, if we look at a clock and we imagine the world on that clock, that basically we are about six minutes old. We’re about six minutes into this like worldwide.  And so when we look at all the changes that have happened in the world, the majority of them have happened in the past 150 years. Like, it’s like the biggest input of change in our, in, in our environment, which then impacts our internal environment has happened since the industrial food. You know, the industrial Revolution kicked in the 1800s.  So prior to that, we were, you know, primarily for the first, you know, I don’t know, just tens of thousands of years, we were all hunter gatherers. 11,000 years ago, we moved into the neolithic farming era, where we started to literally put down some roots in the whole kind of Mediterranean region known as the Fertile Crescent.  And that’s when we first started the introduction of the gene, HLA, which is the human leukocyte [00:05:00] antigen. So we actually changed our immune systems by changing the way we re you know. Sought our food, our resources, right? And so that was one change, which also HLAs what increase your response, your risk of other autoimmune conditions and immune, like viral sensitivities, mold sensitivities, environmental sensitivities.  That’s what the HLA kind of brought to the table of new kind of diseases, right? Then we really saw the next biggest change in the industrial revolution in the 18 hundreds. So we were cruising along for about 11,000 years, you know, and then suddenly another big change. That change was significant. And then even people like Western a price.  And Dr. Pottinger were commenting in the late 18 hundreds saying, wow, something’s changing. We’re seeing changes in dentition. We’re seeing changes in health expression thanks to this industrialization of our food. So we started milling sugar, flour, and salt. We started having more accessibility to these things.  Refrigeration began, and suddenly we had more [00:06:00] access to foods and ability to start to factorized our food sources.

By World War II, we made another big change. We had leftover ammunition from two major world wars, and we decided to invest that into big Ag and big pharma. And so in that world, we started to change things even quicker.  So basically those folks born before World War II had a little bit of a stronger foundation, you know, genetically epigene, genetically, they had a little bit stronger foundation that maybe they had some new exposures. But it didn’t really pick up momentum until after World War ii. It was also in the 1940s to 1960s, we started introducing hormones into our food systems.  We started giving women, basically, if you were a mother in 1940s, fifties, and into the early sixties, you had a very high chance of being given DES just prophylactically to prevent miscarriage. So we started introducing hormones and that level, we started [00:07:00] introducing hormones into the feedlots, you know, that started factory farming animals to, you know, feed the masses.  And so things started changing. And so we also then saw that with that change, that started to have a ripple effect in diagnoses of other health conditions. So, I say this so people understand that it’s not like we went to bed one night with no concerns and woke up the next day with a problem.  It’s been insidious. These changes have accumulated over time. But the changes in the last 50 to 70 years have been. Even bigger. And so when you say what is the cause, why now? Well, we, you know, even the good old World Health Organization in I think 2012 stated that those born after 1980 are not likely to have the same longevity as their parents.  Right? So we started noting difference in longevity. We’ve also noted the trend in longevity in United States, that we’re the only developed country in the world that is actually [00:08:00] either everywhere else they’re either stable or improving on their longevity. And we, even prior to the pandemic, we’re losing longevity on an annual basis.

Dr. Weitz: Right?

Dr. Winters: And so we were sounding the alarm for some time that, oh, something’s weird here, but it’s picked up momentum. And there’s a lot of reasons for that. I mean, some scientists would say we are in the era of despair because the things that have affected our longevity in the US are suicide and drug overdose. So when we look at the pandemic, one of the biggest fallouts of that was the mental health fallout, right, of isolation and whatnot.  That took an already vulnerable population of, you know, pain mentally and emotionally, and amplified that. So that might have some impact. But we’ve also seen an incredible spike in young people with cancer. Like when I left medical school, the average age of cancer in the 1990s was 68 years old.  Cancer used to be considered a disease of the aged. Today’s the average age is 48 years old. So in just a 30 year period of time, we’ve seen a 20 year different gap difference.

Dr. Weitz: We also, during the pandemic we saw a sedentary, overweight population gain 30 pounds and do a lot less activity.

Dr. Winters: Well, you know, and it’s interesting that in that 2018 Chapel Hill, North Carolina Chapel Hill study that came out, that showed, this is 2018, mind you, that showed that less than 12% of Americans were considered metabolically healthy.  Right there, when you think about metabolic dysfunction.  That is all cause mortality, right? That’s your top killers at that time was cardiovascular disease, followed by cancer, followed by, diseases around obesity, which led to like cardiovascular disease, diabetes, kidney dysfunction, the neural neurological disorders, including Alzheimer’s, you know, dis dementia and properly prescribed pharmaceuticals.  So the proper prescribed pharmaceuticals was the number five killer. Now it’s the number three [00:10:00] killer. So those were the things that were happening in 2018. With this 12% of our population being metabolically healthy, that’s a problem. And instead of us saying, what are we gonna do about it? Let’s lean in and get curious and do something about it.

Then the pandemic happened and we went from, well, here’s another crazy study. So in 2022, a study was published that led up to 2020. So just as things were getting started that showed that actually less than 6.8% of us are metabolically healthy. Wow. So we were already seeing within a two year period of time, we dropped that by another 50%.

Dr. Weitz: And then I saw the CEO of Kellogg’s on TV during the pandemic talking about how great it was that so many people were eating boxed cereal for dinner.

Dr. Winters: Yeah, fabulous. Because talk about job security for doctors and cancer, but you know, like, because this is what’s so crazy is we’re looking at data from 2020 and before, which was already put in the writing on the wall.  We’ve not lifted up the corner [00:11:00] of the rug to look underneath to see what the reality is. But I would say we are probably way less than 6.8% metabolically healthy in this country today. And that reaches beyond our borders as well. I mean, we see now we have rates of cancer and diabetes overtaking the US rates in places like India, in places like Mexico.  You know, places like the UK and Canada are right close with us in our stats as well. And so no one’s asking why Ben, and this is where, you know, we may not be able to say one cause because this is what standard of care likes they want one cause in one case, of course.

Dr. Weitz: Yeah.

Dr. Winters: Right. But cancer itself is, even the American Cancer Society says it’s a collection of hundreds of diseases.  And when we can look at those diseases and we can look at the health of our nation and our entire global family and realize we are getting sicker and sicker by the year we aren’t asking the right questions and we weren’t bringing together the right solutions. [00:12:00] And that’s where my passion and purpose lies in all of this, and why I’m excited that we get to have this conversation.

Dr. Weitz: That’s great. One more question in this realm, which is what do you think about some of the ways to test for early signs of cancer.  Do you like the Grail test and the full body MRI?

Dr. Winters:  So I, you know, it’s interesting ’cause I’ve been on this journey for myself for over 34 year, well, it’ll be 34 years in September for my own cancer journey, as well as helped tens of thousands of patients directly and hundreds of thousands indirectly for decades now, my biggest wish during this last 30 years was to find a non-toxic, so non-contrast dye toxicity, such as gadolinium, and a non radiation toxicity, known ion ionizing radiation, known carcinogen, right way of evaluating someone’s.  You know, insides, you know, in, in a profound way. So we’ve leaned on things like ultrasounds, x-rays, PET scans, [00:13:00] CT scans, even mammograms, and DEXA scans. Those are what we had. But those all come with shortcomings and they also come with a lot of toxicity. ’cause almost all of the devices use some form of radiation and almost all of the imaging uses some type of contrast dye.  So, just to give an example, five CT scans in your lifetime is equivalent to exposures of Hiroshima or Nagasaki, radiation wise, right? 

Dr. Weitz: Yeah. I think that’s amazing. Most people don’t realize that they, their doctor says Get a CT scan. They get a CT scan. That’s actually the equivalent of between 30 and 50 x-rays.

Dr. Winters:  Exactly, and we’re now doing this, like for even the biohackers, like, oh, I wanna go and take a look at my body fat content with a CT scan. I’m like, please don’t, you know. So when I heard on Peter Attias podcast in 2019, an interview at Dr. Attariwala from Prenuvo, from that time in Vancouver, BC, you know, Vancouver, bc, [00:14:00] a complete unknown in the United States, I immediately got on the horn and said, how can I get patients to you right now?  To get this imaging, which is using no contrast dye and using no radiation in a high resolution, high sensitivity, high precision repurposed MRI, which this amazing brilliant MD who’s a radiation oncologist, who also had a, like a chemical engineering brain, like a PhD in that realized he could rebuild and repurpose the MRI to make it more effective.  Now since then, we have others that have come to market. Simon one, Ezra, Prenuvo, you know, all of those are out there, 

Dr. Weitz:  So you’re a fan of the full body MRI?

Dr. Winters:   Huge. Huge because we, so just when that started coming out, I started sending patients up to get them in Canada. Then they opened up an office in San Francisco and then started moving all over the us and now beyond that.  We were probably their first customers. Like really it was like why they came into the US is because my community was looking for a non-toxic approach because data is really powerful and [00:15:00] compelling. And then we started seeing things like we were able to start diagnosing things that were missed for years in people.  We were able to catch things super early, like I can’t even tell you how many early stage brain cancers, thyroid cancers, breast cancers that were picked up accidentally incidentally, of people who thought they were healthy, right. So powerful. That’s great. So powerful. So I’m a huge fan because, I mean, first of all, I think it should be standard of care.  I think it should replace all of the conventional MRIs that are out there. Those who still argue that gadolinium is a must in evaluation, need to read the book more than meets the MRI specific to gadolinium toxicity, to realize that the the benefits you get from adding that gadolinium are so minimal, but the risks are kind of lifelong.  I personally am a lifelong gadolinium poisoned patient. My kidneys are destroyed from that. I still deal with the fallout of that over 30 years later. Wow. People will likely take that to my grave. And so, you know, it’s  This is not something 

Dr. Weitz: And the FDA has a warning against gadolinium because it builds up in the brain.

Dr. Winters: Exactly. So here’s what do we do with patients with a brain tumor. We are having this scan every three months with gadolinium. So suddenly, are we actually looking at brain tumor pathology, or are we looking at gadolinium pathology, or are we looking at gadolinium driven pathology? Right. So suddenly it’s like we’re clouding the picture, literally and figuratively.  So to your point, the imaging has come a long way. I’m very excited about that. I hope it becomes standard because it’s still outta the price point of a lot of people. And that’s part of what our work in our nonprofit is about trying to raise funds for until these become standard of care. How do we help people finance the right way to do their healthcare?  And then specific to the early diagnostics testing. Gosh, Ben, I’ve been at this for so long that I’ve watched many companies come and go in the early diagnostic space from videssa, which was a test that used to be able to evaluate if a breast lesion was [00:17:00] cancerous or non-cancerous. We were very excited about that.  They’re no longer on the market. We were excited about ONCOblot, which was checking for a specific protein, an enox protein, which is an early sort of fingerprint. Cancer and even to the point where you could identify the source of the cancer, the tissue that it was arising from that was pulled off the market gallery, you know, finally a few years ago, gallery came out and everyone was really excited, myself included.  But it has a lot of false positives and false negatives, you know, so there’s a huge, there’s a lot of room for error. I still think that it’s worthwhile, but people need to take it into context, you know? Right. Don’t just put all your eggs in that basket, that you’re either all good or all bad. Get more information to round it out.

Dr. Weitz: So if you’re going to do one test for cancer prevention, it would be the full body MRI.

Dr. Winters: I like that. And then I do my version of testing, which tells me of course, lot information. Right, right. And we can dig into that next, but I wanna speak to a test that was out on the market that was FDA approved the same price [00:18:00] range as gallery that had a much higher sensitivity and specificity by the company DeTar. They’re coming back online by end of this year, is what the rumor on the street is to be an early diagnostic. There’ll be about $300 more expensive because they are they have a few more steps to their methodology to Val for validation to create that precision, but for about 1200 US dollars.  Last I was told DeTar will be available for early diagnostics and. Again, it was already out on the market. And FDA approved gallery is not, I don’t believe gallery is FDA approved. I could be wrong. So gallery folks, I, if I’m mistaken, please correct me. But it’s, it is still an available direct to consumer test for early diagnostics.  It’s not you know, a hundred percent, but it’s still something. So yes to imaging that’s non-toxic, yes to early diagnostics. I believe this is a field that will continue to explode. There’s really cool tests in the, in research right now, like breath tests. There’s already tests like you can test [00:19:00] for pancreatic and lung cancer through breath.

You can test for breast cancer through tears. There’s already a lot of early diagnostics that are approved and that are out there. You just have to know about ’em. And that’s, I think the key here is accessibility. A lot of people have no idea of what you and I are talking about, that these things exist.  Why are these not made known? Because you don’t make money from capturing a smoldering ember in the basement. You make money when the entire house is engulfed in flames. Right, right. So it’s not financially appropriate for the big pharma or the big radiology departments. If you’re catching things either preventative, like early diagnostics, it doesn’t, you don’t make as much money from prevention or early diagnostics.  And, you know, I sound like a conspiracy theorist, but man, I’ve been in this for so long. My husband was a cancer drug design for crying out loud as his vocation and worked for Merck for years to tell you that there was no interest. [00:20:00] In trying to change the outcomes or actually prevent cancer, that’s not where the money lands.  So, you know, as, as awful as that sounds, anybody who’s worked in that industry will tell you that this is an accurate assessment and it’s just the way of the world. It’s, we have

Dr. Weitz: a profit driven healthcare system, and if it, that provides positives and negatives and that’s the bottom line. We,

?: yeah.

Dr. Weitz: Maybe at some point want to ask, do we want to have a profit driven healthcare system? Yeah. So now’s the time. Tell us a little bit about your personal health journey with ovarian cancer.

Dr. Winters:  Sure. So, golly, I don’t even know if I was ever knew what health was. But I’ll tell you as someone who you know, was born in 1971, no one was breastfeeding.  That was not in vogue. And so, you know, my mom was trying to find which formula worked best for me ’cause I was sick on all of them. So the pediatrician tried everything. They finally settled on soy formula, which that probably is where a lot of my problems [00:21:00] began. I also, it was normalized, my pediatrician normalized my pooping once a month as a toddler.  Once a month. Once a month because it was my pattern. So as an infant and a toddler and all the way up through my teen, only imagine what your microbiome looked like. Exactly. And they put me on basically baby gas X at that time. ’cause my belly was constantly extended. I was in excruciating pain. All these issues like.  But normalized, it was just normal. So just give her this, that will, that’ll take care of it. By the time I was nine, I started menstruating. No one questioned that. Wow. This is 1980 for crying out loud, right? Not normal, not common today, unfortunately, common still not normal. But no one was questioning the why of that.

By the time I was 11, I was put on birth control pills for endometriosis and polycystic syndrome. Wow. 11, 11. By the time I was 14, I had my first bout of cervical dysplasia. 16. The second bout you just like on and on it was diagnosed with juvenile, rheumatoid arthritis. By the time I was 16, no one, myself included, thought I was unhealthy.  There was just a pill for that. You just got the birth control pill when you were nine. You would just take an antibiotic. If you had an yeast, you know this, then you’d take a yeast, a anti-yeast drug. When you got a yeast infection because of the antibiotic. It was just. That was just normal, right? By the time I was 19, everyone thought my symptoms that were, that was showing up in the ER every single week almost for the six months leading up to my official diagnosis in the fall of 20 of 1991, they just said, oh, it’s just your IBS flaring.  It’s just your RA flaring. It’s just your, you know, PCOS flaring or just your endometriosis flaring. So it was again, normalized until I landed in the ER with a hundred percent bowel blockage, a grapefruit size tumor in my right ovary, lesions throughout my liver, my entire abdomen, a belly full of fluid, known as malignant ascites.

Pulse oximetry. My oxygen levels at room were in the low eighties, high seventies. Wow. I wasn’t able to eat or drink anything for days on end ’cause it was excruciating pain and coming back up. ’cause I didn’t know I had [00:23:00] a blockage, like just everything. They finally looked under the hood. Right.  So I was put into that category of a histrionic teenager, just drug seeking. And yet I kept telling ’em, I don’t respond to the pain meds. I get really sick on them. I don’t like these drugs. No one, they just thought I was there to like, get another drug and they would just write a script and write me off at the same time.  So that’s where I landed in, in the er and a different doctor on staff that night who took one look at me and realized, oh shit, you know, I just was extremely cachectic and I had this big drum belly. And he did a proper workup and realized, oh, something really bad here. So, fast forward, it took a couple weeks to get the official diagnosis, but he saw the, they, I got an MRI at that time, that’s what was available to me in my tiny little mountain town.  They pulled the ascites fluid. It was bloody so they knew it was malignant at that time. They, you know, all these things were happening. They realized they had the bowel blockage and they sent me home to die. Yeah, that was just, they’re like, you’re too sick, you’re in, your organs are in [00:24:00] failure. You’ve got this blockage, it will absolutely kill you with a single dose of chemotherapy.

So from that fast forward, I couldn’t eat. And so for the next two and a half months, then I didn’t. So I deeply fasted, not on purpose, not intentionally, I just out of necessity and that started to slow down my need to have the ascites drained every few days to maybe once a week to just every couple of weeks for the first two and a half months.  By the end of that two and a half months of fasting, I resolved the bowel blockage, I resolved the ascites, and I just sort of stabilized the fallout that was happening. Now, they didn’t know what to do with me ’cause I was still alive and they didn’t expect that. I didn’t expect that I wasn’t fighting it.  I just wanted to understand it. And that’s what’s led me to where I am today. I wanted to understand why a 19, soon to be 20-year-old was dying of what was considered a disease of the aged that had been missed. Four years that no one questioned my extremely high doses. ’cause all liter literature at that time said, oh, birth control pill is protective against ovarian [00:25:00] cancer.

Oh, it’s not at all if you’re given a dose as high as I was given. Right. In the 1980s. Right. And all the way through it also, no one understood until a few years after my diagnosis would be another five years when I learned that I had the BRCA mutation. So some people think of that as a death sentence.  But really it’s just a methylation problem. Right. And ’cause I’d also been a self-proclaimed vegan since I was 16 years old. I was severely malnourished and I had none of the co-factors for methylation. I also am missing, I would be another. Eight years beyond 19. So in the early two thousands, I also had my genes tested, my SNPs tested and realized I’m missing the Gstp one.  The GSTM one. So I was missing single nucleotide polymorphisms that helped me detoxify. So all those years of medications, all of those years of birth control pills, all those years of living near four EPA Superfund sites, all of those years of eating a very toxic diet for myself, a [00:26:00] very highly processed vegan diet, because I thought I was doing things right by taking care of the animals, but I wasn’t taking care of this animal.

I was doing all the things wrong, right? But I was living like the outside world looked like I was the uber athlete. I was student body president, I was head of my volleyball team. I was, you know, like all the things on the outside world. I looked like the picture of health. And the picture of success, but inside it was rapidly dying.  Wow. Now I’m a sophomore in college pre-med and literally given months to live, and so that’s what has led to my entire career. Ben is starting to learn about, like in the early months of my diagnosis, I started to go to the library and there was no Dr. Google. There was literally, there was a Dewey decimal system and microfiche where I could do my research on and started to understand.

I started running across the work of people like Otto Warberg and the me, the mitochondrial metabolic dysfunction of cancer versus the genetic mutation theory of cancer. I started to run across the work of Dr. Mina Bissell, who was one of the originators of the studies of the terrain, the extracellular matrix and the tumor microenvironment.  And I started to run across the work of Robert Aler and excuse me, Robert Ader and Candace Pert, and at that time an unknown cell molecular biologist by the name of Bruce Lipton, who were all talking about the epigenetics and the impact of trauma and the impact of emotional impact on your immune system.  It would still be another 20 years before Bruce Lipton’s book came out.

Dr. Weitz:  The Biology of Belief, right?

Dr. Winters:  But in 1991, I was reading his research and so these were the people that started informing my understanding that my biography definitely had impact on my biology. My environment outside of me definitely had an impact on the environment inside of me, and I started to wanna understand it and wanted to start to learn ways to resolve it.

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Dr. Weitz:  Let’s talk about the metabolic theory of cancer, which contrasts with the more mainstream somatic, or. DNA mutation theory of cancer. And I’d like to start this part of discussion with a quote from your book, which I thought was very well said.  Cancer is not a disease of our genes. It’s a disease caused by what we are feeding them.

Dr. Winters: Beautiful. Do we need even need to say more? I love it, but Well, and I love it you brought that up because in 1914, Dr. Theodore Bovary coined the concept of somatic mutation theory of cancer, saying that cancer is simply bad luck of genes that are broken and gone rogue and now can’t stop and actually accelerates the proliferation of cancer cells.  That has been where we have put all of our resources of research and treatment basically ever since. Now, there was a little window though, ’cause in the early 1920s, another character came along a bit controversial. Dr. Otto Warberg, who was the biochemist saying, this isn’t a genetic issue, this is a biochemical issue.  And started to realize that the mitochondria, those little powerhouses of our cells looked different and were less in number in cancer tissue. And he started saying, I think that this is happening more upstream. And then the genes come later. And so actually for a chunk of time, he even won a Nobel Prize for this.  But from about the mid, you know, early to mid 1920s until the mid 1950s, [00:31:00] his theory dominated over the somatic mutation theory and lots of accolades. The world of cancer was all tied up in the biochemistry and in the study of that, and that’s where the energy was. But then Watson and Crick, actually a woman that Watson and Crick took credit for, found the DNA helix.  And we pendulum back over to saying, oops, let’s throw the baby out with the bathwater of the mitochondrial theory, metabolic theory, and go back to mutation of genetic theory. And that’s where we’ve been ever since, including, you know, claiming the war on cancer in 1971. Basically flatlined of our overall survival rate since then.

You know, no real, really impactful, impressive changes in this sense then. And the best part is that this somatic mutation theory has actually been disproven. Thousands of times over the, and all over the globe. And that if this was truly a genetic disease, the little organelles within our cells called nuclei are like the [00:32:00] big biggest organs within our cells are where we house our genetic material.  That is the genetic hard drive of our cells. If this was a genetic disease, if you removed that genetic hard drive, the nuclei of a cancer cell and you replaced the nuclei of a healthy cell, you should turn that into a cancer cell. And the opposite is true. If you removed the nuclei, the healthy cell and you replaced it of a cancer cell, you should turn that into a healthy cell.  That doesn’t happen. Never happened, never will happen. ’cause that’s not where it starts. So good old auto was right. It starts upstream from that. Your DNA is protected by the health and wealth of your mitochondria, which is another little organ within the cell that is doing a lot more than just producing your energy.  It is to me, the mitochondria do three major thi things. So yes, at the end of the day the output is energy and an energy exchange. That is life, you guys. That is just the way it is. We live and die by the function of the energy produced from our [00:33:00] mitochondria. But what the mitochondria do before that energy production is three things.

Number one, it takes in information, lots of information. It is a receiver. Okay. And so when I mentioned earlier about what’s happened in the past, you know, 170,000 years where mitochondria began as bacterium. Of which they today make up upwards of 20% of our mass. So think about that for a moment. You know, we’re kind of mostly a bacteria.

That should probably be a clue that, hey, we’ve brought a lot of things like antibiotics and glyphosate, which is a massive antibiotic into our systems. That should probably be a clue of some problems. But we also have brought in, as I mentioned, all the changes after going from hunter gathered and Neolithic farmer to industrial food to post World War.

Lots of new information coming at those mitochondria. So first is they take in everything in, on and around them, including people, places, and things. That’s all. Second big job. They are translators of that information. So, [00:34:00] you know, sometimes when you guys try and use like your Google translate, sometimes it doesn’t translate well, right?

Sometimes like the system is off. Well, that can happen with our mitochondria as well. Like sometimes it’s not translating as well, or it’s so overwhelmed by the input of information, it can’t translate it fast enough or correctly enough. So we’re also the result of how we translate that data. And then the third job of the mitochondria is to signal out, to communicate to the surrounding cytoplasm, to the surrounding organelles, to the surrounding cells, tissues, organs, structure, et cetera.

That is when you have good information in, you have good information out, but if you get crap information in, you get crap information out, or if you get good information in, but poor translation, that can impact. So now you’re likely realizing that there’s a lot of places where things can go wrong within the mitochondria and all of our conditions today.

Cardiovascular disease to diabetes, to dementias, [00:35:00] to autoimmune conditions, to cancer are all based on our mitochondrial function. And earlier you and I talked about the 6.8% or less of us being metabolically healthy, what that really means is that there’s less than 6.8% of us who have well-functioning mitochondria.

And so that is where, and what’s really cool at the time of our discussion been is about, my gosh, maybe six months, eight weeks or six weeks, eight weeks ago, a study came out in I believe nature that literally asks the question or makes the statement that the somatic mutation theory is dead. Oh, really?

And that the metabolic mitochondrial theory is actually the most dominant theory of cancer today. Wow. So I’m hopeful. ’cause I never expected, I mean I’ve been at this for over 30 years, right? Even though I was reading about this all those years, people thought I was knuck and Butts. Even reading like Mina Bissell, who’s been this [00:36:00] amazing researcher, you know, since the eighties, people just di completely dismissing her.

When Tom Creed’s book came out in 2011 claiming that cancer is a metabolic disease, everyone dissed him. When Travis Kristofferson’s book came out, I believe 2014 or 15 on Tripping Over the Truth, which was a consolidation of Tom’s book along with Shar Ji’s book, the Biography Biology, or excuse me, the Biography of Cancer.  And of all Maldi suddenly conversations around this started happening and basically the last 15 years, right? Just conversations despite us being able to disprove the somatic mutation theory for decades. Finally, people are starting to lean into saying, well, maybe we should start actually evaluating for studying and considering more wholeheartedly the work that Otto Warburg started in taking it to the next level, which started to make us look more at these metabolic mitochondrial underpinnings that this is actually what’s running the show.  Not the good old gene. 

Dr. Weitz: Still wonder though, if metabolism, the metabolic health, blood sugar, all that insulin, if this still isn’t only one of the causes, and wouldn’t we actually be better talking about the terrain theory of cancer?

Dr. Winters: Well, and that’s how my brain sees it, so, okay. The metabolic mitochondrial, that’s still, to me, it’s still the expression of what the terrain is being exposed to.  Right. So, for instance, been like most people now, like we started out with the six hallmarks of cancer, Hanahan and et al in, I think 2006 came out with the six hallmarks, and then we, I think in 2010 or 11 we’re like, oh, now it’s 10 hallmarks and we’re up to like 16 now. Right? We have all these hallmarks, but no one’s saying, but what makes those hallmarks express?  Right? It’s the same thing like, well, what makes the mitochondria not work? No one. So I, that’s my passion, is to say, well, what is contributing [00:38:00] to the dysfunction and the lack of number and the lack of vitality of the mitochondria. So even my colleagues in the metabolic oncology space who are focused in, they’re still focused on the tumor and the tumor metabolism and the tumor cell, and not why that metabolism went amuck.

Dr. Weitz: Right.

Dr. Winters: And so that’s what I speak about in the book. The metabolic approach to cancer are sort of my 10 drivers, of which there are likely more, but even some of those drivers collect a few things. So things like your epigenetics, the blueprint of your genes that were handed down from generations that make you vulnerable to certain expressions depending on input of data, right?  Input of food, light water, emotions, stressors, chemicals, toxins, et cetera. That is your the input is let’s see, you like fielded by or filtered by your blueprint, your genetic blueprint. And so they’re not set in stone. They’re [00:39:00] dynamic, and you can change the expression of, or the silencing of those genes with your day-to-day dietary and lifestyle choices and an even standard of care.

We will tell you today that upwards of 90 to 95% of all cancers are absolutely diet and lifestyle impacted. So it’s not what I’m saying. It’s like, we know this, we say this, but we don’t do anything about it, right? In standard care. So that’s one of the big drops in the bucket. The second big drop in the bucket is what do you eat or don’t eat, or when do you eat, right?

So the fuel, what are you fueling those cells with, right? Everyone’s trying to give like, oh, the blue zones, or, oh, the Mediterranean diet, or, oh, the keto, or, oh, the carnivore. Oh, the vegan, or, oh, the raw. It’s like, no it’s the raw material. What raw materials are you giving your body, and how does it meet your DNA, your genetic history and your needs in this moment at any given time.

So maybe what you need today will be different than what you need next season. Right. So that’s another piece. And the third drop in the [00:40:00] bucket, the environmental, I mean, my gosh, we have 80 to a hundred thousand new chemicals that have come out into the market since the 1960s, and yet less than a thousand of them have been properly tested.

And we’ve virtually done no testing on how they interact with each other. So suddenly talk about all that information coming in. We don’t even understand, beginning to understand what we’re being exposed to and how our bodies are dealing with it. And then we look at the microbiome, which was completely ignored until we can monetize it basically with really expensive shit.

And so we, you know, that’s, you know, that’s just what is what it is because as nature passes, as Chinese medicine practitioners, Ayurvedic practitioners, so 5,000 year old medicine and beyond we’re saying it all starts in the gut. We didn’t quite understand what. In the gut, but we certainly do now. And so for instance, the microbiome.

Now, we almost wanna put those two together, the microbiome and the immune system, because they’re almost impossible to separate. And so with that being said the [00:41:00] microbiome determines your immune system. It determines what nutrients you absorb. It determines what nutrients you convert to make them bioavailable.

Right? It determines what your how you’re going to respond to other medications, to other treatments. For instance, if you are missing certain things like Akkermansia for instance, you may not respond to immune therapies, right? There are certain chemotherapies that if you don’t have the right meta mi microbiome, it just falls flat.  It does nothing. We actually, 

Dr. Weitz: has anybody tested adding akkermansia supplements to immune therapy?

Dr. Winters: Yes, they have. There’s actually multiple studies on this and oh wow. You go to PubMed and say microbiome and checkpoint inhibitors. Let’s just give you a really simple one. Improvements with supplementation, right?  Or changes if you to pull, like, or detriment when you pull out those particular nutrients or those particular organisms. There’s plenty of studies, in fact I mean, I was trying to think the [00:42:00] last time I took note. I think there’s over 600 studies in this globally right now. On adding Akkermansia or just specific like, and Akkermansia is just one, but that’s like one example.  But there are certain, there’s other organisms that are important for response to certain therapies. I see. Okay. But like Akkermansia has become really well known with specifics to icis, which are the immune checkpoint inhibitor drugs. And so that’s one that you’ll see a lot of data on. And

Dr. Weitz: by the way, Akkermansia has a huge effect on blood sugar and insulin.

Dr. Winters: Exactly.  It’s a, it’s nature’s GLP one inhibitor.

Dr. Weitz: Exactly

Dr. Winters: right. And so here’s where it comes back again to the metabolic drivers like you. Here’s the, you know, like your client, your patient, your listeners may not know this, but like radiation, yes. Is radiation effective in treating cancer? Absolutely.  But it’s also effective at causing cancer. So how do you wanna make it work for you and not against you? One of the most important ways to make it work for you is to sensitize the cancer [00:43:00] cells to the radiation, which then protects the healthy cells from it. And you cannot sensitize cancer cells to radiation.  If your system is full of insulin and glucose, you desensitize the cancer cells. So basically they are impermeable to the radiation when your insulin is high. We know this, we’ve known this for ages, and yet what radiation oncologist is telling, there’s a few Dr. Brian Lunda. You know, is one that comes to mind.  There’s a few radiation oncologists out there. Dr. Christie Kesslering comes to mind to understand this and understand this well, that if they can get their patients metabolically healthy, metabolically flexible, insulin depleted, glucose depleted, their patients have much better outcomes on the radiation.

Less side effects. Their immune systems don’t tank, and they maintain you know, a pushback of the cancer, you know, and even into remission. You also don’t get those patients if you are, you know, not potentiating them. Like if they’re blood sugars are high, that’s a problem. But also [00:44:00] you can protect their cells by giving them things like high dose melatonin, which will potentiate, sensitizes those cancer cells further while simultaneously protecting the healthy cells.  Why is this not standard of care? These are not expensive interventions, and they’re not difficult interventions, and they’re, I guess if you

Dr. Weitz: were to say something to a radiation oncologist about using almost any supplement, one of the responses would be, under no circumstances should you ever take antioxidants.  Right. And, you know, I we have that famous rant from Dr. James Watson, who you mentioned, Watson and Crick.

?: Yeah.

Dr. Weitz: Talking about why would anybody ever take an antioxidant, right. At the same time, knowing that eating fruits and vegetables that are rich in antioxidants are one of the healthiest things you could do.

Dr. Winters: Really, the ORAC score of a blueberry, for instance, far outweighs most things you would take as a supplement. Right. And yet no one’s telling them to avoid blueberries. Right. So, but, and the other side of this is that

Dr. Weitz: can you just talk for a minute about this topic? Yeah. Can taking a vitamin C uncouple the effects of radiation or conventional chemo, or, in my opinion, it’s more like saying if I bring this plastic shield onto the battlefield against you know, rocket fire, am I pretend, am I gonna.

Dr. Winters: Really, if you were looking at a truly antioxidant free diet to support the claim of the radiation oncology team, people would have to be drinking distilled water and eating cardboard. I mean, that’s just the reality, right? And that’s just not possible. Right? Here’s what’s very interesting. I will say that we do, as clinicians want to, if we’re going to use an oxidative cytotoxic therapy, we want to have that effect.  Right. [00:46:00] We do not want to quench that effect. Sure. But we wanna be prepared to quench it. After the half-life is down, we want to come in and clean up the environment as quickly as possible. So for instance, the other thing about radiation oncologists is they do not understand anything about redox chemistry, which is knuck thoughts because there is no such thing as like purely pro-oxidant or purely antioxidant.  There’s sort of these gray areas of we move in different arenas. So for instance, low dose oral vitamin C. Two grams, four grams, six grams a day, and split doses is actually antioxidant. We actually do advise our patients on the day of radiation or the day of chemo at least four to six hours around it to avoid things like vitamin E, selenium, zinc you know, vitamin C in the oral forms, just so we can harness as much of that oxidative stress as possible.

We call it the kill phase. We wanna take full advantage of that, but [00:47:00] like day after you’re going to town on those things you need to clean up and scavenge that reactive oxygen species as much as you can so you don’t further overwhelm those mitochondria. Right. So that is a really big strategy. The other thing is, the strategy is we can potentiate those oxidative therapies like radiation by giving the patient a bump, a hit of oxygen, whether it’s from HBO t insufflation, or even nasal blow by prior to going into their radiation.  You actually open up the pores, for lack of a better word, of the tumor to make it penetrable because radiation is very difficult to penetrate what we call cold tumors or really cloaked tumors. And so the rate, the oxygen therapy adds a level of oxidative stress that actually opens it up more and makes it more penetrable by the radiation.  So we might enhance the radiation effect and, but simultaneously that. So would you do that the day before the radiation or? I do it, I like it within an hour to two hours before the Oh, really? That’s my ference

Dr. Weitz: now. So, so when you [00:48:00] say su fla sulfation, if everybody’s not familiar with that, you’re talking about using ozone?

Dr. Winters: You were using ozone nasal cannula. Well, actually not nasal can. It’s too vulnerable there. But like rectally vaginally, you can do that before going in for a radiation therapy, especially if it’s like a colorectal cancer. We definitely wanna get the oxygen right to that region, you know? So those are the things, if it’s like head and neck cancer, just regular nasal cannula of oxygen, if it’s sort of something more diffuse or in the abdomen, we might put somebody in a chamber.  We want to potentiate that, which will help the healthy cells and focus on the cancer cells simultaneously. That’s one example. The other example is ketone bodies. So therapeutic ketosis mean ketone bodies of above millimoles above three actually increase oxidative stress. So it potentiates your chemo, it potentiates your radiation, but simultaneously protects the healthy same things like hyperthermia, and same things like high dose IV vitamin C, high dose iv, vitamin C above 25 grams intravenous is pro-oxidant. It will fact in like fully impact and synergize the oxidative kill phase effect of those things. So when a radiation oncologist tells a doctor or tells a patient, Nope, no way are you doing my IBC because that is an antioxidant. They’re fucking idiots. I mean, excuse me. But it’s like that is the most pro oxidative therapy out there.  We’re making your work better.

Dr. Weitz: That’s, well, when your lab, you should do a study having patients get IV vitamin C along with their radiation or chemo, then

Dr. Winters: those studies exist. They’re already published. They do. Okay. And they’re already, and they’re favorable. You will potentiate. So not just for radiation, but also for chemotherapy.  So some of those really toxic chemotherapies, it will potentiate the effect of that and protect the marrow simultaneously.

?: And then

Dr. Winters: you come in with your antioxidants [00:50:00] around it, like the day before your treatments the, you know, day after, depending on the half life of the treatment. Then you clean up and scavenge that, what’s still running around the system causing chaos where it doesn’t need to.  That’s where we bring, this is why integration. Right. This is how it rounds it out. And so, this is where, so we were just talking about like the microbiome and we’re kind of heading out to the other drops. So really quickly, the other big drop, the immune system talk about harnessing that inflammation circulation and oxygenation.  Hormone modulation circadian rhythm, stress response. This is such a big one in the cancer world and mental emotional. So these are the 10 major drivers. So for instance, if someone’s willing to eat the right diet, do all the right pills and potions get the right standard of care treatment, but they’re not, like for instance, going to bed before 11:00 PM and they’re on screen till two in the morning, that’s completely disrupting their entire terrain, right?

You know, that insulin [00:51:00] growth factor wiping out the ability to detoxify, which is the time our bodies do that in the middle of the night. You know, things like that. But if they’re also not dealing, say with the skeletons in the closet of their mental emotional resilience and their traumas, they also are less responsive to therapies.

So folks, for instance, with high ACE scores, adverse childhood events. They have a much, they’re wired differently. Their, the nervous systems are wired differently. Their immune systems are wired differently. So until they basically rewire that, reprogram themselves and resolve that trauma, they’re gonna continue to be playing that record.

And it will mean that their treatments don’t land as effectively, whatever they are. And if you’re in a state of constant fight or flight, if you’re in a sympathetic nervous system, we don’t heal and sympathetic. So being afraid, so living in fear, which are com, our complete culture like seems to thrive on and seems to perpetuate the money machine on.

If you’re living in a state of [00:52:00] fear, you can’t receive, no matter how good the treatment is from standard of care, from alternative care, from healers. If you’re in a constant fight or flight, you can’t even receive that healing.

Dr. Weitz: What are your what are a couple of your favorite supplements for patients?  You, you were talking about immune system function. Yeah. When you have a patient and they have low white blood cells or low lymphocytes and you know, they need some boost to their immune system what are some of your favorite strategies?

Dr. Winters: Well, one of my favorite strategies is that there’s a kind of common denominator of deficiencies within patients that are dealing with a cancer diagnosis, but also and so I’ll just start with that.  So they’re really simple. You’re missing you’re missing the fat solubles typically very common. So a DK, right? Those are the main ones. You’re missing major minerals. So zinc, selenium, magnesium are the big ones you’re missing the kind of co the the big, like the B12, the big methylator.  You’re missing that, those are your big ones. So magnesium, zinc, vitamin D, vitamin A, vitamin K, and B12 are the ones that are classically missing across every patient I’ve ever run labs on. Right? Both from functional labs to conventional labs. It’s missing, right? And so we know those are all the important co-factors for immune function, right?

And for lots of cell, like you, like magnesium alone pulls like 200 different genetic levers. And vitamin D alone has major epigenetic, you know, liver pulling and packed as well. Vitamin A is pretty much your entire immune system, right? And K like we so downplay these and we’ve gotten so fat phobic and we avoid the things that those come from.

And we give people synthetic forms and we give folks plant-based forms. So in fact, the studies that show that things like vitamin A and E can cause cancer, it’s because those are the plant-based forms. Right that are misunderstood and misappropriated. So betacarotene, we don’t, we don’t ever give our patients betacarotene, right?  We don’t ever give our patients cyan cabal forms of B12. We don’t ever give our patients [00:54:00] so, solen, methionine forms of selenium. Like we know we need to use certain nutrients that are depleted in our cells. So when we deal with those, if I get those foundational ones, I’m not

Dr. Weitz: sure if everybody knows what the issue is with seleno-methionine.

Ah,

Dr. Winters: so the methionine aspect in

Dr. Weitz: a person who’s dealing with cancer, who’s acting cancer,

Dr. Winters: okay. 

Dr. Weitz: The idea of that high methionine might promote cancer?

Dr. Winters: Yes. And we can tell very sur. I mean, first of all, you can get testing now to actually know which metabolic pathways are deranged. But we can surrogate tests with a homocysteine level.  And so the homocysteine level is elevated and we do what we call a homocysteine challenge. So we give some of those co-factors, you know, high dose for a couple days and we retest the homocysteine. If the homocysteine comes down, drops significantly, we know that was just a methylation problem. But if the homocysteine barely drops or stays the same or even goes up, we know we have a methionine driving the cancer process.  So you don’t want to take supplements that contain the methionine form. And [00:55:00] selin methionine is the most common form of selenium. Interesting. And sodium is a very powerful PTP 53 tumor suppressor support. It’s really great for methylation support, but if you’re using the wrong form, it can backfire.

So we, we want to use the right form. So because I’m a clinician who’s had to piecemeal all of these things together, we actually created a formula. And this is not to mean a shameless plug. It’s that I needed it, it didn’t exist, so I created it. That’s sort of the story of my life, you guys. So it’s like these tests didn’t exist.

So I created, these courses didn’t exist. So I created, this hospital didn’t exist. So we’re creating like it’s, instead of me waiting for somebody else to do it, my personality is just. Do it, like get outta the way and we’ll just do it ourselves. So we created a company called Mito Vita. So the life of the mitochondria and one of our sort of flagship pro products is this Nutra master, which are those replaced or those repleted sub, you know, nutrients I just mentioned are all in one place.

And so that’s kinda like my form of a [00:56:00] multivitamin. ’cause multivitamins otherwise are crap. I don’t ever recommend ’em for anybody. They have too many things that are not therapeutic enough, but they also have too many things that are actually could be drivers and somebody dealing with cancer. And so I just wanna avoid those.

It’s very difficult to find good quality ones. So for years we just had patients take these things individually. Now they take it in one. One pill versus Yeah. My,

Dr. Weitz: I don’t, I’m sure you must be aware of it, but Integrative therapeutics has least s Yeah. Thrive multivitamin.

Dr. Winters: Yep. Yep. And so, but you know, for me, I don’t want anything that contains calcium, boron, iodine, iron non methylated B vitamins.  Sure. Still has a few of those things. And so I love Lisa. I think she’s stinking brilliant, but it’s not a supplement. I personally recommend for my patients on that. But if you’re not cancering, I think it’s perfect. But if you are cancering, there’s. Too many things we’re learning that we have to be pretty careful and pretty thoughtful on.  But when you talk about the immune system, I know there’s a lot of people out there who think that supplementation of vitamin D is [00:57:00] controversial, but the reality is that we’ve all used detergents on our skin to break down the ability to absorb our vitamin D three. We are all terrified of the sun.

So we’re not getting our 10,000 units minimum just to prevent rickets a day exposure to vitamin D from the sun. Perfect world. If you could lay out naked every day for an hour, we’d all be fine. Right? But no one’s doing that except for a few biohackers, right? So at the end of the day, one of my most compelling, you know, levers, especially if people have single nucleotide polymorphisms that make vitamin D absorption difficult, whether it comes from natural sources or supplements, we do need to bring on a supplement for these patients.  It pulls so many levers. It’s a really important one to optimize. Another one that we like to use that really optimizes the entirety of the immune system, the entirety of the metabolic system, the entirety of the like hormonal modulation and DNA protection is high dose melatonin, right?

Again, your like, probably the most studied outside of missile toe [00:58:00] alternative cancer therapy out there. Hundreds if not thousands of white papers on it. If people wanna go, people like Dr. Dr. Ri Ryder Russell Ryder famous researcher in melatonin chemistry, because everyone’s always like, oh, it’s gonna replace your function.

It doesn’t. It doesn’t. That’s a myth. And so there are ways that we can harness the power of high dose melatonin like I potentiate. I give somebody like, you know, 500 mil, you know, IU or 500 milligrams of for going to radiation therapy or getting an X-ray or a CT scan to both potentiate the impact of the radiation where you want it to go, but also to protect the healthy cells.

It’s a TP 53 protector as well. And so these are some of the tools we can be using that brings us back to this conversation and need for integration that it shouldn’t be either or. It should absolutely be an and. Absolutely.

Dr. Weitz: I have a million more questions, but running outta time. I’m sure you are too.  I’d like to get one more particular [00:59:00] question. There’s a particular issue that has come up that is a peeve of mine and that is there’s at least one prominent ca researcher who also has researched cancer and recommends a low protein diet, particularly because. According to him and some data that higher protein diets, meaning including animal protein raises IGF one levels.  And in your book you point out how IGF one levels are raised by insulin being produced by eating a higher carb diet. So therefore, eating a lower protein vegetarian diet is automatically gonna be a higher carb diet. And so we measure IGF one levels in all our patients, and I do not see uniformly that our patients following a healthy diet with even [01:00:00] three times a day of animal protein.  We, I do not see a big increase in IGF one levels. And so I’ve always been very skeptical about that. So should. Patients who wanna prevent cancer follow a lower protein diet because of the fear of raising IGF one? Or is the concern more about eating sugar and high glycemic carbohydrates?

Dr. Winters: So, couple, there’s a couple places to unpack here.  So biggest prevention is going to be carb restriction, right? That’s because 70%, some research shows upwards of 90%, but let’s just be conservative. So let’s say 70% of all cancers are very heavily driven by insulin. All I would say a hundred percent are to some degree, but 70%, it’s pretty much the main driver, right?  Right. That other 30%, it’s a driver, but there’s usually other players such as glutamine. Methionine cystine, right? Loose arginine, [01:01:00] right? Somebody’s so what you’ll notice is those are proteins, right? So this is where the conversation gets confusing to people. Healthy metabolism of healthy cells and metabolism of cancer cells are two different animals, and they’re happening simultaneously.  So when you look at, does sugar alone cause the cancer process it doesn’t it. So what you have to have a metabolic derangement that then switches and says, I want to utilize glucose as my primary fuel. That doesn’t start that way. It’s a response to something stressed in the environment that allows that ship to happen.

Similar to the protein question. So let’s talk about this for a moment, because IGF one is definitely a problem, but it’s a problem once the metabolism is switched over, right? And so absolutely too much protein will drive IGF one, [01:02:00] but it is far less common to see that than it is to see IGF one being caused by too many carbohydrates.

Also, people always forget too much steroid, which they give every freaking patient who’s on chemotherapy, which even in Dr Balter Longo’s newest book in the first few chapters says this should be pulled, which I’ve been saying for 30 years from every patient. It’s like peeing in the wind when you give a patient a steroid for with going through cancer treatment.

And then the other side is, so she’s talking about corticosteroids like prednisone, which are often included in the protocol to reduce inflammation. All included. It’s a, it’s an, it’s a CYA. But I tell folks that even if you get the CYA of the pre the preload drugs, if you’re going to have a reaction, you’re gonna have a reaction.

And you’re in that chair with a lot of people close by that are gonna give you the proper drugs like histamine, antihistamines, and even more steroids if you do have a reaction. So why don’t we already know they’re there? Just keep those things on hand to give them those drugs right away because the patient’s still doing [01:03:00] CYA drugs are going to have that reaction that are going to have it, right?

So it’s like we’re preempting things that we actually can treat if it shows up in immediately and deal with it immediately. But the other things that drive up insulin growth factor stress. So cortisol drives up IGF one

?: right

Dr. Winters: over exercising. ’cause it drives up insulin, it drives up cortisol. Okay. And sleep.

Lack of sleep. So two nights of bad sleep, just two nights of bad sleep will impact your IGF one levels. So we may be blaming the wrong things for IGF one. I see interesting other drivers for it. But if I have a patient who’s actively cancering and their IGF one is elevated, we’re gonna go after all of those things.

We’re gonna see, well, is this stress? Is this sleep? Is this too many carbs? Is this too much protein? And we will adjust accordingly. We will get back the data and we will be able to know what was the driver for that patient. And so to me, that’s what’s really exciting is we don’t have to [01:04:00] guess, right?

You’re modulating

Dr. Weitz: nurturing and you’re testing to see what’s happening with that individual patient. And that’s how you provide individualized, personalized care.

Dr. Winters: And so, Ben, when someone says. It’s always bad or it’s always good, you need to kind of run from it. We know across the board carbohydrates are the driver.  Too many carbs and too many processed carbs in particular are the driver of many of our chronic illnesses today. We all do not expend enough energy, right, to utilize the carb intake we have. And then because of the things like altered metabolism from light exposures in the wrong times of day because of the endocrine disruption, we are completely swimming in from the chemicals in our environment to the exogenous hormones we take to the plastics we’re exposed to the glyphosate drenching our entire planet.  Today, that impacts the way we metabolize things. Like we have to become aware of everything we put in on and around us, including people, places, and [01:05:00] things, which is where we started our conversation today. And the simplest place to start is just to be aware of when you eat. And what you’re eating. Like that’s the thing that’s like your base camp.  And to start to realize that we’re all leaning towards way more carbs than ever before, right? And that some of us can tolerate more than others based on our epigenetics. So you can even take that information in. So even the question about IGF one, my husband would love to be carnivore, but he has a PA two snips.  He has a CSL one snips. He’s got snips that when he eats red meat, he can get by with a little bit, but if he eats too much, his glucose and insulin go up and his ketones drop.

?: Wow. His

Dr. Winters: body thinks it’s a candy bar. But there other people who have like the seven oh gosh, I can’t believe I just forgot it.  The seven FL 7 22. Ugh. I cannot believe I just completely lost this one. There’s another SNP TCF seven L two, which is for those folks who wanna be like a vegetarian or vegan. They’re, they are [01:06:00] so predisposed to diabetes and the issue is they don’t have the enough amylase to break down all the carbohydrate.  So the point is that there’s a time and a place to be more, you know, higher protein, more higher carbohydrate based on our biochemical individuality and our single nucleotide polymorphisms. And in, if we’re even then using a clinical application, we may wanna pulse things like maybe we need to restrict.  This is why I’m such a huge fan of fasting and intermittent fasting, because you basically starve all of the potential drivers, glucose, fats, and proteins that could potentially be causing a problem. So if you pull that out for a little bit of time, you make those cancer cells a little more vulnerable, and then you pair that with some other pushing therapies such as oxidative therapies of some sort, standard of care or otherwise, you completely change outcomes.  Right. So we might get caught up in these dogma wars of which is the best diet or which is the best foods to avoid [01:07:00] or to take. But really some of our most compelling data is when we’re not eating and how to layer that in more strategically with some of these therapeutic interventions.

Dr. Weitz: Oh, so let’s wrap here.  It’s another continuing conversation. Tell everybody about your programs, your training programs for practitioners and whatever other contacts you want everybody to have.

Dr. Winters: Thanks, Ben. Well, first of all, folks can start by following me at drnasha.com, D-R-N-A-S-H a.com. That will probably take you to all the things that we’re up to.  That’ll take you into the nonprofit land of MTIH, which is Metabolic Training of Health, where we’re doing research and innovation, but we’re also doing patient grants to get access to this type of care. And then also working on funding for a really powerful hospital that we hope to build on this model, around this model.  And then you can also learn about the product line that we’ve developed is very specific to the metabolic health and metabolic oncology space. So we’ve been using it internally in our community for some [01:08:00] time, but that’s where it’s been tough because there’s no, there’s a lot of stuff on the market that doesn’t quite fit what we need for our particular population.

We also have a data platform that’s a clinical decision making tool, our MT that is about to launch to the public, which is a really powerful way to. Make this approach more available and scalable by clinicians. ’cause it takes a lot. We’re about a thousand strong now in 46 countries of clinicians and allied health professionals who’ve come through my training program.  But this requires a lot of time and energy to master this information and to apply it. And so we’re creating tools to make this more accessible and scalable by clinicians globally. And so you can learn about my book, the Metabolic Approach to Cancer, all the things that Ben and I talked about really go into greater detail about this.

And then the book, the Metabolic missile toe and the future of integrative oncology is kind of like the next gen. This is actually written for clinicians as a kind of a toolbox for them to access in the integrative oncology space. But ultimately, you know, if you go to [01:09:00] Dr. Nayha or mth.org, you can sign up for our newsletter to keep abreast of all the conferences and all the podcasts I do where I’m guests or I have guests on.

And then I think the final thing I want your listeners to hear is we’re doing a really amazing event. I hope this comes out in time for that. In October 10 10, by the way, October 10th is our Health Day on the calendar, right? So for the last couple years we’ve been doing some events, just kind of one day virtual things on 10 10.  But this year we’ve had such a demand. We’re actually creating a conference and we’re bringing together all the things that personally for me. Are about how we impact the terrain being in the best of metabolic health and metabolic, you know, like regenerative health with region farming and soil mitigation and environmental medicine all under one roof.

So if you go and Google Metabolic Health Day conference, and we’ll give a link to this you will see that. E any one of our keynotes would fill a stadium on their own. Really unbelievably brilliant people that I’m really proud to have on board. Plus 30 other well-known, high, [01:10:00] highly followed, highly influential clinicians and influencers out there in the world making, making a difference in health as we know it a healthier planet for healthier people.  So I’m excited about that because it’s bringing a lot of these voices together that are impacting policy, impacting planetary health and impacting people health. So is that in person? It is. There’s an option for in-person in Tucson, but there’s also an option for virtual live streamed as well as recorded if you can’t be, take part in the livestream aspect.  So we want this to be a toolbox for creating a better future.

Dr. Weitz: Great. Feel free to post a notice on my functional medicine discussion group of Santa Monica closed Facebook page.

Dr. Winters: That would be amazing. Thank you for that opportunity. 

Dr. Weitz: You’re welcome. Yeah. Thank you so much Nasha. Another amazing discussion.

Dr. Winters: Thanks, Ben. You’re the best. Appreciate you so much. Thank you.

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Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcast or Spotify and give us a five star ratings and review.  As you may know, I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and want to promote longevity. Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Dr. Peter Kozlowski discusses Improving Fertility with DNA Testing and Functional Medicine with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

Genetics and Fertility: An In-Depth Discussion with Dr. Peter Kozlowski
In this episode of the Rational Wellness Podcast, host Dr. Ben Weitz engages in a comprehensive discussion with Dr. Peter Kozlowski, a leading functional medicine practitioner, about the role of genetics in fertility. Dr. Kozlowski, with over a decade of expertise, delves into how genetic testing and a functional medicine approach can optimize fertility treatments. He shares insights on various genetic polymorphisms, such as MTHFR and FSHR, and their impact on fertility, alongside preventive measures and treatment strategies. Additionally, he emphasizes the importance of mitigating environmental toxins, optimizing mitochondrial function, and the role of both partners in addressing fertility issues. Dr. Kozlowski also introduces his advanced AI-powered platform designed to support practitioners in applying functional medicine effectively.
00:28 Guest Introduction: Dr. Peter Kozlowski
02:12 The Importance of Genomic Analysis in Fertility Care
02:58 Genetic Testing Advancements and Personal Stories
04:23 Preventative Use of Genetic Testing
08:30 Environmental Toxins and Infertility
12:52 Personal Infertility Journey and Genetic Factors
14:42 Key Genetic Factors in Fertility
19:22 The Role of Resveratrol in Fertility
22:53 Promotional Break: Apollo Wearable
24:24 Additional Important Genes in Fertility
27:58 Genetic Factors in Nutrient Status and Fertility
28:18 Vitamin A: Importance and Testing Challenges
29:10 Micronutrient Testing and Deficiencies
31:10 CoQ10 and Fertility
31:40 Genetics and Personalized Interventions
33:04 Detoxification: Genes and Controversies
33:51 Approaches to Detoxification
40:10 Mitochondrial Health and Genetic Risks
43:56 Genomic Testing for Fertility
46:00 Men’s Role in Fertility
48:14 Conclusion and Contact Information
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Dr. Peter Kozlowski is a leading Functional Medicine practitioner with over a decade of experience dedicated to transforming healthcare.  He is the creator of Root Cause Practice Pro, an advanced AI-powered platform designed to empower both functional Medicine practitioners and individuals seeking answers to chronic health issues. Dr. Kozlowski has written two books, Unfunc Your Gut and Get the Func Out. He lectures for the Institute of Functional Medicine about fertility and how using a Functional Medicine approach that includes looking at genetic SNPs, that is a very compelling way to help patients.  His website is doc-koz.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

 

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Today I’m excited to be having a discussion about genetics and fertility with Dr. Peter Kozlowski. He’s a leading functional medicine practitioner with over a decade of experience. Helping to transform healthcare.  He’s a creator of Root Cause practice Pro and advanced AI powered platform designed to empower practitioners and individuals seeking answers to chronic health problems. He’s written two books, Unfunk Your Gut and Get the Funk Out. I heard Dr. Kozlowski lecture for IFM about fertility and how using a functional medicine approach that includes looking at genetic polymorphisms is a very compelling way to help patients.  And I thought it was really a. Fascinating. And I also appreciate the way Dr. Kozlowski is able to blend DNA testing with the overall approach especially when it correlates with testing because there’s genetic testing out there, but a lot of times it’s hard to correlate it. And I have found personally in practice, when you’re trying to take all this genetic data and blend it with lab data and everything else, and do it in a reasonable amount of time, is definitely a challenge. So while Dr. Kozlowski is dedicated to transforming he, his healthcare, his proudest achievements are family related, being a father to his daughter Sawyer, a husband to his wife Mackenzie, and a soon to be father of a baby boy. So Dr. Kozlowski, thanks for joining us today.

Dr. Kozlowski:  It’s an honor. Thank you so much for having me.

Dr. Weitz:  So why is it important to include a genomic analysis and fertility care from a functional medicine perspective?

Dr. Kozlowski: Yeah, I think, honestly, I think it’s the most important thing to include, and this is coming from somebody for that for 12 years, told people not to do genetic testing.  Because I, as you you heard me at IFM, but the gene when I first started training that everybody talked about was M-T-H-F-R which one of my patients famously called the mother EER gene. Right. And because when you read about it, it was like it was. The root cause. It was the root cause of everything.  Right? Right. If you had M-T-H-F-R, it would cause heart disease, infertility, inability to detox. And when I dug into it, it just didn’t make sense to me that one gene could explain everything. And over my [00:03:00] years of telling people not to do genomics, not to do genetic testing, genetic labs got. Way more advanced.  We know a lot more about genetics and now the testing is incredible. When we order a genetic profile, you can get hundreds of SNPs that are related to your ability to detox your risk for dementia, your risk for what kind of diet you should follow, r regards to your weight whether you’re at risk for heart disease, diabetes, clotting.

My own personal story is anxiety and depression. I, that, those, that’s how I ended up in functional medicine. And I found that genetically I don’t make serotonin. And I was able to use my genes to then optimize, like my supplement protocol to help my body make serotonin. And I feel like it’s really helped balance my body people’s ability to absorb vitamin D, magnesium.  There’s B12 and then, you know, not just M-T-H-F-R, the full methylation pathways. Autism is something I work with that I have not yet tested a child with autism that didn’t have significant predisposition to autism. So the reason for testing is to opt. You know, unfortunately in my practice, everybody I’m seeing is already with.  Disease. So 99% of my patients have a chronic disease and I’m like their last hope for reversing it before they’re out of meds or surgeries or things like that. Ideally, genetics to me should be used preventatively, right? So we did a full genomic panel on our daughter when she was two months and. I have an idea of what she’s set up for.

So I have a strategy that I’d like to take as she’s growing up to hopefully prevent disease. Right. So, right. We know she doesn’t detox well, so you can put her on binders in certain situations. You can upregulate phase one and phase two detox. Whether it’s deciding how to supplement, right?

I think that’s one of the hardest things is like determining which supplements what people should be on. And I was always a minimalist. It was like, [00:05:00] well, let’s test what’s wrong with you. Let’s get it rebalanced and then you don’t need any supplements. And then I found for myself, like I don’t absorb magnesium at all.

So I’ve now on a magnesium three and eight, which I think has totally changed my life. So I would love to use genetics as preventative medicine, but I’m using it with my families that, you know, the kids have autism and we’re optimizing. Do they need high dose folate? Do they need oxytocin for infertility, endometriosis?

How do we down regulate it? How do we optimize hormone balance? How do we optimize detox? For patients who have a family history of dementia, you know, are you at risk? Right? Do you have the genetic predispositions? What we know about dementia is the changes in the brain happen start 20 years before disease starts.

So using it that way. So there’s so many different ways. So the way I use it now is typically to, you know, with, again, to optimize a condition that we’re treating, whether it’s optimizing [00:06:00] a mold detox or cardiovascular care, or dementia prevention or autism or detox or whatever. But. I would love to use it primarily just as prevention to let people know what they’re at risk for and how we could prevent that.

Dr. Weitz: Yeah. It’s interesting how many of the common chronic diseases today, particularly neurodegenerative diseases, actually start to present some of the early signs. 20 years earlier, the Parkinson’s, same thing. You know, patients get constipation. They have certain symptoms that are very characteristic, that they have a higher risk in 20 years of ending up with Parkinson’s.  Let’s intervene. Then. Let’s not wait until the person is officially diagnosed.

Dr. Kozlowski: Yes, exactly.

Dr. Weitz: And the same thing with autoimmune diseases. You know, these things gradually, slowly, you have this chronic inflammatory situation where the immune system’s attacking the body. And let’s not wait until there’s enough damage where you are now officially diagnosed with the disease.

Dr. Kozlowski: There’s so many genes related to like the immune system and inflammation and certain people are just way more prone to autoimmune conditions, right? So again, it’s whether that’s, if it’s already developed, you kind of optimize an anti-inflammatory plan or you do what you can to prevent it right.  I really think, like, you know, when I, as I was trained with the Institute of Functional Medicine, it was all about like personalized medicine, right? Like, that’s what makes us different as, right? Like practitioners, like this is like we focus on personalized medicine. Well, genetics like truly makes it personalized, right?  Right. You treat the same condition differently. Like, I have a heavy metal detox protocol or a mold protocol or a glyphosate protocol, but when I know somebody’s genetics. It completely can change based on what that

Dr. Weitz: person needs. In your presentation at IFM, you showed some statistics about the [00:08:00] rising rates of infertility from, you know, less than 1% to over 19% in the us over 40 years.  Over 40 years. Yeah. Still, that’s a shocking number. 

Dr. Kozlowski: That’s insane. There’s not many diseases that go from less than 1% to 20% in 40 years.

Dr. Weitz:  Right. So what do you think are some of the contributors?

Dr. Kozlowski:  I think the argument that the genetic haters will say is, well, our genes haven’t changed. Right?  So why do you talk about genetics? When you talk about infertility, what, why I think the rate has gone so crazy is our environment. And. Our environment is way more toxic. And the books that I wrote, one of them get the funk out is it’s the whole point of the book is how our hormones are being damaged by the environment, right?  And it all comes down to mitochondrial dysfunction. I really think most chronic disease is based in mitochondrial dysfunction. There is nothing more [00:09:00] damaging to our mitochondria than environmental toxins. And so when I say toxins, I mean there’s lots of ’em, right? There’s millions of them.

Unfortunately, right now there’s only a few that we can really test. We can test heavy metals, we can test mold, we could test levels of glyphosate we can test herbicides and pesticides and plastics. So there flame retardants there. You know, there’s a lot we can test. There’s still a lot we cannot but, you know, over the course, if you look at, you know, again, the rate of infertility in 1990 being less than 1%, and now, 19%. There’s not like a causation study, but when you look at the correlation of the amount of toxins being released into our environment you know, it’s a straight up curve with the correlation of what’s happened. So it, you know, my, my theory of why it’s so out of control now is. We have an increasingly toxic environment.

We have more stress. Our guts are in worse shape, right? So most people are familiar with that term, leaky gut. Our gut is a barrier to keep the outside world out, just like our skin is a barrier, just like our lungs are a barrier. Because we have these leaky guts, because we’re putting all these chemicals on our skin because we’re spraying our foods with all these chemicals we’re breathing in this stuff.

There’s gateways of that outside world that’s way more toxic to get inside. Toxins are fat soluble. They look for fatty places to get stored. When our detox is overwhelmed, every cell in your body is surrounded by a membrane that’s made up of 50% fat. Right, and particularly one of their favorite place to go.

Those toxins are our reproductive organs. So for men it’s the testes. For women, it’s the ovaries. Thyroid disease is the most common autoimmune disease. So toxins surround these reproductive glands. Our hormone glands create mitochondrial dysfunction. Those glands don’t work the [00:11:00] way that they used to, and now you have an infertility problem.

Right. And I do believe it’s very multifactorial. It’s not just one thing, it’s all of these things. The bigger picture, creating this toxic world inside of us that is, you know, different people affecting different things. But one of the things that’s really affecting is people’s ability to reproduce now.

Dr. Weitz: Yeah, and those of us who are paying attention to what’s happening in the environment, it’s clear that there’s all these increases in toxins. I’m living here in Santa Monica, in Los Angeles, and we live through these horrific fires, and there’s all this data about how particulate matter from smoke. Leads to all sorts of damage to the body.  We have all these floods and hurricanes and that inevitably leads to mold buildup afterwards. And the way we build our homes that are airtight leads to increased mold. And [00:12:00] there’s so many reasons why we are. We’re hearing about microplastics and the brain and the other organs. It’s clear that we live in a very toxic environment and that those toxins are getting their way into our bodies.

Dr. Kozlowski: And so, and unfortunately there’s not causation studies yet. But you know, like I said that you perfectly explained the correlation, right? We know that this is getting worse and worse. They’ll admit it when there’s fires. They don’t admit it from our day-to-day exposure, but.

You know, what we do see is the infertility rate was less than 1%. It’s now one in five couples. Right. Right. So it, you know, we could just say, we have no clue what’s going on. Or we could say, Hey, we know these things are getting into our bodies at way higher rates. We know these things once they’re in their body damage or mitochondria, we know mitochondrial damage leads to infertility.  Right, right. 

Dr. Weitz: So, yeah.

Dr. Kozlowski: And it, I mean. So the reason I became so passionate about this subject is my wife and I had to go through infertility [00:13:00] treatment. My wife had stage four endometriosis for seven years, had pelvic pain going to the doctors saying that she had pelvic pain, that she thought she had endometriosis, and they kept telling her, no, you don’t.  No you don’t. Finally, the last OB told her to go to a physical therapist. For pelvic floor exercises. Right. It wasn’t until she saw an IVF doctor that they did a tubal study and her tubes were so scarred that they had to remove them.

Dr. Weitz: Yeah, that’s sad.

Dr. Kozlowski: And she, when we went back and did her, because I didn’t get to do her genetics until she was pregnant, but when we did her genetics, what we, well, I knew the whole time when she was 20, she had moved into a moldy building, worked at an airport.  She had really nasty environmental toxin exposure. We did her genetics. We found out she doesn’t detox well, specifically the chemicals that are present at airports, and that’s where she worked. We saw she had four different [00:14:00] genes that gave her anywhere from like a two to five times risk of endometriosis.  We know endometriosis is a mitochondrial disease, so, you know, that was, you know, that story is kind of what got me so passionate about getting into infertility. ’cause it was, you know, it was, it’s a, it’s our story and it took us four year, three years of trying before we actually got pregnant and we have a daughter now.  But the, and I guess why I wanted to get started on that is like, this is something with the one in five, like. Everybody knows somebody now going through IVF, right? Whether it’s a family member or a friend. Like you know, the, at 19% we all know someone affected by this issue, right?

Dr. Weitz:  So let’s go through some of the genetic factors.  One of the factors is the project progesterone receptor gene, which can contribute to miscarriage or infertility.

Dr. Kozlowski: Yeah, so there are a lot of genes, [00:15:00] right, that are connected, and so the, there’s not like one specific one that I would just focus on. Of course, like when we do the. Like a, we, what I, what it’s called is a female health panel.  Right? And so then we start looking at ways, how can we optimize a woman’s fertility? And what you’re talking about the progess, PGR when women have a snip, which is a polymorphism maybe that, you know, I don’t know if everybody, every listener is totally familiar with. 

Dr. Weitz:  Sure. Why don’t you explain what a single nucleotide polymorphism is?

Dr. Kozlowski: Yeah, to keep it I like to keep things super simple. We have about 23,000 genes. There’s what’s, what most of the population has, and you get one copy from each parent. So, when it comes to looking at a gene, you can have what’s typical. You could have one variant, or you could have two variants, meaning that you have a variant from mom, you have a variant from dad, or you have both.  Sometimes having two variants from the, what’s [00:16:00] most common is good. Most of the time it’s. Bad. So when you look at a genetic, to me, when I look at a genetic report, what I look at first is what is the prevalence? What percent of the population has that combo? Right? So what percent of the population has zero copies?

What percent has one or two copies? And now what the research has where the research is basically when you have one copy, what does that increase your risk for? When you have two copies, what does that increase your risk for? And then what? The most important step of all of it is how can you intervene on that gene?

Right? So that’s probably the most important thing to understand is if you have a gene, the importance of knowing is what can you do about it? So, for example, somebody with the progesterone receptor gene has an increased risk of infertility. Basically, they need more progesterone to bind up their receptor and.

So if you’re, if you have the PGR [00:17:00] gene. Your receptors don’t bind, the progesterone doesn’t bind as well, so you need more progesterone. You’re gonna be more predisposed to having problems with too much estrogen. And so somebody with that, the first thing I would do is I always test for estrogen dominance, right?

So if I test someone for estrogen dominance, I’m looking at their progesterone levels in the second half of their cycle to see if their progesterone’s high enough. Somebody with the PGR receptor is gonna need higher levels of progesterone. Progesterone is your first pregnancy hormone, so there’s a lot of women who can get pregnant, but then they miscarry, and after a couple miscarriages, the doctor will then be like, well, let’s put you on progesterone now to maintain your pregnancy.  There’s probably. People listening that it was either them themselves or their husbands listening. It’s like, yeah, my wife needed to go on progesterone after we had a couple miscarriages. The benefit of knowing a gene like that is, is, and I’ve had patients who have this, who have not yet started their [00:18:00] fertility journey.

But they can take that to their OB doctor and be like, listen, I need extra progesterone when I get pregnant. So if they find out they’re pregnant, they could go on progesterone early and maybe prevent a miscarriage.

Dr. Weitz: So, and that’s because progesterone helps get the uterus ready and helps prepare for implantation and.

It’s the main hormone

Dr. Kozlowski: During the luteal phase. After ovulation, exactly right. So progesterone is what gets exactly like you said, gets the uterus ready. And then once there is actual fertilization and there’s pregnancy, that hormone skyrockets before the woman starts making HCG. So it’s a vital hormone right at the beginning to get pregnant and to maintain a pregnancy early on.  Right. So that’s a great example of a gene that it’s be very beneficial for a woman to know whether she has it early on, so she knows. And then, you know, that gets into the whole discussion also of estrogen dominance where, [00:19:00] you know, the classic symptoms of PMS, bloating, anxiety, insomnia in the two in, during the ltil phase you would be more, I would be more aggressive as a physician.  To treat the estrogen dominance early on in more natural ways through like detox through supplements to help keep that balanced.

Dr. Weitz: Yeah. One of the supplements you mentioned in your discussion, which I looked up subsequently, and it’s an amazing amount of data around resveratrol. Yeah. Talk a little bit about the impact of resveratrol and how that can impact fertility and how it can modulate some of the hormones involved.

Dr. Kozlowski: Yeah, I mean, resveratrol when they say drink one glass of wine a day, right? That’s, that, the point of it is resveratrol, right? So obviously if you’re working on pregnant, I mean. One glass of wine, I guess would be okay. You don’t wanna overdo it if you’re [00:20:00] trying to get pregnant with wine.  Right. In general. Yeah. I usually don’t tell people to start drinking wine to get resveratrol, but it’s a, it’s an amazing anti-inflammatory. Right, right. And and really the way to think about. Estrogen progesterone for me as a functional medicine doctor when I’m working with a woman is estrogen can be very inflammatory if it’s not balanced right.  Too much. It’s just kinda like that thing of, too much of anything is a problem. So too much estrogen is a problem when it’s not balanced by progesterone. So we try to do things to lower the inflammation related to that, and resveratrol is a way to do that.

Dr. Weitz: You mentioned variants in the FSHR and the FSHB genes that affect hormonal regulation affect endometriosis.  And then I think you mentioned resveratrol is something that can help regulate in that regard.

Dr. Kozlowski: Yeah. So [00:21:00] FSH stimulus follow helps the eggs mature and. Women who have this FSHR gene, the follicle stimulating hormone receptor, have been found to have a lower number of healthy eggs, right?  And so that’s another gene where my kind of argument is to protect the egg production or to optimize the egg production. One of the things resveratrol has been shown to do is to basically, downregulate that gene, so it’s not as much of a problem. So a woman makes a healthy amount of eggs, right?

An example I gave during the discussion is I have a woman right now, a patient going through IVF therapy that she’s young and she can’t get. A lot of eggs, right? When you go through IVF, the first, one of the first steps is to get the eggs out of the woman. And she’s not getting them. And they can’t really figure out why.

Well, she has this gene that [00:22:00] kind of predisposed her to not making enough eggs. She also has extremely high levels of glyphosate that we’ve tested for, and she can’t detox it. Well, these are all things that we’ve found out kind of too late, right? It’s already, she’s already too late in the process. Now we’re using that to hopefully lower inflammation, to hopefully down regulate it.  But it’s hard, right? Like, you know, with any disease, once it’s started it’s hard to reverse it. And so the goal would be to prevent things like this. So when a woman with this gene is definitely like at a young age, can go on a resveratrol to help protect

Dr. Weitz: her eggs in such a situation, what’s a range of dosage that you might use for resveratrol?  Typically like a hundred, 150 milligrams is what I would go with. Oh, really? That’s a pretty low dosage.

Dr. Kozlowski: Yeah, I’m, I mean, I try to be conservative

Dr. Weitz: usually. Oh, okay. Yeah.

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Dr. Weitz:  So let’s talk about a few other, what are some of the other important genes, whichever ones you want to highlight.

Dr. Kozlowski: Yeah, I mean, the one that I kind of made fun of that you know, that everybody knows MTH ffr, it is connected to infertility, right? But both men and women,

Dr. Weitz: right?

Dr. Kozlowski: The a 1298 C mutation is particularly a problem in men. It can affect their sperm production. So, for example, a young man right now or that gets their genetics done and he has them THFR.  That’s an important one to know. I just think it was overstated, but [00:25:00] that’s something he can go on. A daily methylation support, which every nutraceutical company makes to basically help support his sperm production right now in a woman. The C 6 77 T mutation was found to be a problem with implantation failure lower ovarian responsiveness.

So again, a very simple. Affordable supplement you get on methylation support if you know you have this to again for a man’s support is sperm for a woman to support the fertility cycle and support like the. Embryo implanting into the end endometrium. So M-T-H-F-R is an important one. I think one of the most interesting genes that I’ve found that is almost, it should be called the m mothereffer, is factor five laden.

Okay. Which we traditionally, you know, think of factor V [00:26:00] laden for like blood clots, right? It’s people with factor V laden clot really easily. So that’s somebody that could get a blood clot in their leg when they’re flying or if it’s worse, it can go to their lungs. And that’s called a pulmonary embolism.

And those people take medications typically to decrease clotting. There’s also supplements you can use. I really got into the factor V in regards to heart disease. I’ve had a few patients with Factor V where we’ve done scans of their coronary vessels and they actually have significant coronary artery disease.

But then the interesting thing was, is that one of the patients with this, she’s a woman in in, in her sixties, but I asked her, I’m like, when you were younger, did you ever have a miscarriage? And she’s like, yeah, I had three before I got pregnant. And it, there’s studies that show having factor five can be associated with it.

Two to four times risk of recurrent fetal loss. And that’s something that if she [00:27:00] had known that as a kid, she could have been on something like Olol, which comes from pine bark or Nattokinase as like a natural anticoagulant. And maybe she wouldn’t have had those, you know, multiple miscarriages when she was trying to get pregnant.

Right, right. So that’s like factor five. I just connected it in a couple seconds to clotting, to heart disease and infertility. Right. So that’s a bad one. That if you know it, it’s very easy

Dr. Weitz: to manage. Right. And is the mechanism for affecting fertility related to clotting as well? Yeah.

Hypercoagulability. Yeah. Okay.

Dr. Kozlowski: Yeah. Yeah. What is, that’s where another, like other, you know, again, people listening to this might be like, well, oh yeah, when I was trying to get pregnant, I was having miscarriages and my doctor put me on aspirin. Right. Right. And so that’s a common one that’s known in the OB world.  It’s like, oh yeah, multiple miscarriages give the patient aspirin. They don’t really know why, when there’s actually could be a genetic component to it.

Dr. Weitz: Right. What are some of the other genes [00:28:00] related to nutrient status that can affect fertility?

Dr. Kozlowski: Vitamin A beta carotene, oxygenase is the name of the gene.  That one is also one that affects men and women. You need vitamin A for healthy sperm production. You also as a woman, need it to regulate ovulation? Vitamin A is something that I, in my opinion, is difficult to test for. I don’t really fully trust any of the lab tests to measure someone’s vitamin A levels.  I mean, you can measure a toxicity, I think. A deficiency is harder to find. So that’s something when I have a patient with that gene, I will put them on 10,000 IUs of vitamin A daily for a man again for sperm. For a woman to regulate ovulation, vitamin A is one that I would be very careful with though, because it is teratogenic, so Right.  A woman, you know, that does, if she’s on it, she, I mean, vi to me 10,000 units should be a safe dose. If I have a woman on it, I’m gonna just check her [00:29:00] levels to just track it to make sure. Typically, like for it to be teratogenic you, you’d have to be on over a hundred thousand units a day or more. But I’d be

Dr. Weitz: cautious with it.

Why are you skeptical of the testing for Vitamin A and which tests for vitamins have you done? Have you done some of the micronutrient panels like vibrate or some of the others?

Dr. Kozlowski: Yeah, so I’ve done the urine testing, I just think, you know, I haven’t as had as much time to dive into the validity

Dr. Weitz: of those tests as I would, you should look at the vibrant micronutrient tests because they do serum and then they do white or red blood cells, so you got shorter, longer term, and they have a pretty robust panel that I have found really helpful.  Does it measure a specifically. It measures, yes, it measures a, it measures many different nutrients. Offhand, did you remember if you found any people with deficiencies? Yeah. I’m working with a woman right now who’s pregnant and she [00:30:00] has that gene that doesn’t allow her to convert betacarotene ol, so we put her on a prenatal.

Yeah, with retinol in it directly, because when you look at prenatal, some of them only have betacarotene. Some of them have retinol, some of them have both. And so yes, I, we found that helpful. And then we found out she, she needs even more. Yeah. Nice. Yeah. I’ll look. And then we’ve been testing at the beginning and then halfway through the pregnancy because the nutritional status tends to change during pregnancy.  Right? Yeah. You typically need to up things. So you’ve seen her levels normalize? Well, they improve when we put her on re retinol, but then during the second half it’s starting to go down again. Okay. She needs even more.

Dr. Kozlowski: Yeah. Yeah. Yeah. That’s definitely, it’s obviously ’cause they’re growing another human, so they’re gonna need more nutrients.  Right. Yeah. I, yeah, I’ll take a look at that test. I mean, that’s, I guess that’s the thing is like, I like to see consistency with my labs is like, yeah, [00:31:00] I find a deficiency, I treat it, the levels go up. And I guess I haven’t felt fully confident in that, but I’ll take a look at that.

Dr. Weitz: Yeah. What are some of the other nutrient status genes?  Coq 10. Okay. A gene is called

Dr. Kozlowski: coq two. Okay. Individuals with that have lower coq 10 production. Men, coq 10 improves sperm motility in women coq 10 I think, through the mechanism of protecting the mitochondria, but can protect against oxidative stress. And then there’s studies that suggest it could thicken the uterine lining.

Dr. Weitz: So coq 10, some fertility experts are

Dr. Kozlowski: just recommending coq 10 now. Yeah, exactly. Right. And so that’s the, I think that’s been like the beauty of using genetics is there’s these, you know, something like that. Like it’s being recommended and it doesn’t work for everybody. Right. And now with genetics, you at least that’s what I’ve found is like, it makes sense now why certain interventions work in certain people, right. And

Dr. Weitz: [00:32:00] then Right. You get somebody 5,000 units of vitamin D and their vitamin D goes up a little bit. Yes. Not in range. Somebody else goes to 120. Exactly.

Dr. Kozlowski: So that’s where like, yeah. That there’s, you know, there like you’ve been in this field even longer than me and it’s, you know, there’s certain interventions that we know that work for a specific condition, but it’s like they don’t work in everybody. And that, I think genetics is kind of putting the ribbon on that of like, okay, now I get it. Right. Yeah. I would rather do genetics before I’m working with a woman going into, you know, optimizing fertility or like, again, a, a family with a boy with, or a girl with autism like.  I know how to then target my high yield interventions based on the individual and success is faster. Instead of like, listen, like we’re gonna try these high yield things first, and then if these aren’t working, then these are kind of usually the second tier of things I would try. But now it’s like we could just jump to, these are all the best things for you because [00:33:00] we know your genetics

Dr. Weitz: right.

And what are some of the more common genes that affect detoxification and how do we deal with toxins? And and then this whole question of toxins and detoxification for some reason has been extremely controversial.

Dr. Kozlowski: Yeah. I’ve tried to, that that in general, I think that’s a good comment is just like, why is the discussion of detox so controversial?

You know, my, my career trajectory was like I was a family practice doctor. And then I went straight into a functional medicine practice on my own. And I had no problem doing like nutrients. I had no problem doing diets and gut, but I was like scared to do detox. I, and I don’t even understand really why like, why I was cautious to go into that field.

My approach to detox in general has always been let’s test your level of toxins. Right? Right. So, I like anything I do, I [00:34:00] like to do it objectively. And so that’s where I personally with that, like, you know, I would do the glyphosate test. I do pre and post urine chelation testing. I would do mold testing if someone has exposure history.

And for me, my, my exposure questionnaire, well, my exposure question is, have you ever lived in a building that had water damage? I don’t like to ask people whether they have mold exposure, because most people will say, most people I tell that I treat for mold. Well, adamantly tell me they don’t have mold exposure.

And so I just ask them, did you ever live in a water damaged building? Right. And then like I use Mosaic personally for the toxin testing. And so they have the tox detect panel which has the phthalates and the plasticizers and the herbicides and the pesticides and. So that for me, I would start with that personally.

Right? Like I would like to get the phenotypical expression are, do you have toxins? Right? Sure. [00:35:00] Well, at the meantime, I want to get your detox genetics. And I don’t think I’m going to be able to name all the genes related to detox. There’s hundreds of them, right? Yeah. So that’s where a genetic report, you know, when you get one back.

There’s a section labeled detox or toxins. Right?

Dr. Weitz: Not to mention that we have this whole family of P four 50. Yes. Detoxification, enzymes, and even apart from genes, there’s all these other things, even foods that can upregulate or downregulate these different enzymes and that can all affect your ability to detoxify various toxins, drugs, et cetera.

Dr. Kozlowski: Exactly. So, well, the way I handle it is I’ll get the toxin testing if we have a positive result, then I go to the genetics and I’m like, whi, which genes are deficient? A pretty common one actually, that you see is inability, in inability or a reduced ability to make [00:36:00] glutathione. Right, which is a huge problem, right?

Because glutathione is our master antioxidant. Like if correct, if I could pick one thing personally to give someone for detox, I would use liposomal glutathione, right? And because when we, when you look at phase one and phase two of detox, glutathione is the only thing that affects both pathways, right?

Right. You can’t find another nutrient that affects phase one and phase two. So that, I think that’s why it’s so effective. And it’s been shocking since I’ve started doing genetics. How many people have reduced ability to make it or recycle it. And so that, you know. You can debate going on a higher dose.

Right. I think there’s typically I wonder what your opinion is. A lot of people like to use NAC n acetylcysteine, which is, you know, what you use to make glutathione. Yeah. That’s a precursor. Right. And so I’ve personally, like I’ve always been, I’ve always chosen glutathione over NAC because I’m like, [00:37:00] what’s the point of giving the precursor if we could go straight to the source?

But I do think a lot of people like to use nac. And so you can make those kind of decisions genetically how to optimize. Sulforaphane is something that I’ve started using a lot more since seeing people’s genetics. You know, you can focus. You always need to balance, I think, phase one and phase two.

So I’d cautious to overdo like, support for either phase and then. Obviously phase three of detox is actually getting the stuff out, peeing, pooping, right. Sweating. So I don’t ever like to, like, if I have a patient who comes in with constipation issues, we are not going to go through detox.

Right, right. You’ve gotta get them, I gotta fix the cut

Dr. Weitz: first.

Dr. Kozlowski: Yeah. So that’s the overall approach I take towards toxins. I don’t, how about yourself? Is there anything that you kind of

Dr. Weitz: do very differently? I mean, I definitely, I am a big believer that you gotta fix the gut if you can’t excrete and you don’t wanna [00:38:00] detox.

So I totally agree with that. I tend to find glutathione more effective than NAC, though sometimes we use both. Some people, claim that they’re getting side effects from glutathione and they can only handle NAC. It’s tricky to find out if the side effects are really coming from glutathione or not, but, you know, if they’re convinced that they are, then I’ll go along with that.

Yeah, absolutely. Yeah. It is funny though that it’s so common they’ll be talking to a patient and one day they’ll have a symptom and it could be. They got a headache. Yeah. And they just happened to start taking vitamin C, so obviously the vitamin C caused a headache. But yeah, it’s not easy.

Right? Yeah. Well, I try to ask ’em to stop taking vitamin C. Give it a few days, try it again. If it keeps happening over and over, then there must be something about their body. But a lot of times you just. Have, you know, some [00:39:00] some symptom that day that really probably had nothing to do with it, but anyway.

Dr. Kozlowski: It’s a good reminder too, ’cause like when I, if I take somebody through a detox, right? Like I was just doing this yesterday for a woman that’s got a lot of mercury plus glyphosate. Right. And, but she’s known that she typically can be pretty sensitive to adding new things. Right? So So you gotta do a little bit one at a time.

Exactly. We did the same thing. Yeah. Yeah, so you kind of do one, add in one new thing every few days or one a week and right. And lower the dosage. It sucks when you

Dr. Weitz: maybe do like, you know, one spray once

Dr. Kozlowski: a day and, yeah. It’s frustrating when you start someone on a full plan and it’s like, well, three days later they have a complaint and it’s like, well, which thing do I stop?

And it’s like, you know, we probably should have done this one at a time. And that, yeah. The

Dr. Weitz: tricky thing though is here you are saying, do I want this patient to take months and months to get this stuff out, or do we wanna Yes. Hit ’em with the full program and they [00:40:00] tolerate it and a few months later they’re feeling great, you know, so, yeah.

Dr. Kozlowski: Yeah.

Dr. Weitz: You gotta make that call. Exactly. What else, what are some of the other genetic factors? You talk a lot about mitochondria. How do you like to assess mitochondria?

Dr. Kozlowski: I typically, you know, as far as phenotypically, you know, I think mitochondria is another thing that’s hard to test. I mean, I use an organic acid test Okay.  To look at the kreb cycle. Okay. I think to me, that’s the best test I know of to, to assess mitochondrial function. Right. I do think there’s lots of people with mitochondrial dysfunction that can still test normal on an organic acid test. So the way now I like to approach the mitochondria, that’s one where I think really looking at the genetics makes a lot of sense.

It’s amazing. The amount of people now I’ve tested who have like specifically like either like infertility issues or chronic neurological issues that seem to be the [00:41:00] people who have genes that predispose them to mitochondrial dysfunction. Right? Right. The, I think the tricky part is, and I think different practitioners would take a different approach is, so let’s say you have a patient who’s predisposed and that’s another one where there’s a number of genes that could predispose you to mitochondrial dysfunction.

But let’s say you do have that genetic risk. Is the strategy to go straight on supplements, right? To support the mitochondria, which coq 10 we talked about is pretty famous. You can use alpha lipoic acid, you could use B vitamins. There’s different ways to glutathione could support the mitochondria.

  1. When I see mitochondrial risk in the genetics, I do then want to go back to my root cause Functional medicine approach is what’s the thing that’s going to be affecting your mitochondria the most? And that is toxins. And those toxins, again, could be the environmental ones, but also they could be food [00:42:00] sensitivities.

Right? Right. It could be dysbiosis, it could be candida, it could be sibo you know. A leaky gut with a standard American inflammatory diet. So when, if I, ’cause I don’t typically like to just order every test for every person. Right? Like if you’re, if you have no history of mold exposure, I’m not gonna do a mold test.

If your gut. Is balanced. Like you’re moving your bowels every day, you don’t have symptoms. I’ll do a microbiome test ’cause someone could have dysbiosis and not have symptoms, but I might not do like a full SIBO test, anode test and all those things. But if you are someone that. Tests for mitochondrial dysfunction, genetics.

To me, I would recommend you then really, you probably need the full gauntlet of tests. Like you don’t want to be messing around because because of the fact, there’s not like to, in my opinion, the perfect way to test, are you expressing this right, because I right. With any [00:43:00] gene I want is the, my first thought is there a way to test for expression, right?

So again, for me, I would do an oat test to see if they, that’s indicating mitochondrial dysfunction. But like I said, I do think there’s lots of people who are normal on that test and still might have it. So then my best next step for phenotypic expression is do you have diseases that could create inflammation in your body?

And so I’m gonna, then at that point, I’m gonna be like, we need to test you for food sensitivities. We need to do a full look at your gut. We need to do a full gut look at your environmental toxins. We should, we need to look at your hormones. We, you, if you are gen genetically pre. Exposed to mitochondrial dysfunction.

I think the best thing you need to do is really make sure your body is as balanced as possible. ’cause to me, those people are the ones that are really susceptible for the chronic diseases that you just don’t want to be dealing with.

Dr. Weitz: Which genomic testing platform [00:44:00] or panels do you like to use for fertility?

Dr. Kozlowski: So I use, personally, I use the women’s health panel with Telex, DNA. The lab is based outta Austin, Texas. Okay. That’s the main lab I’ve used. They, we have a conference coming up, I don’t know when this is coming out, but end of July there will there’s a full three day weekend talking about all the different panels that in Inte X has.

So that’s the, typically, specifically for like women’s health, they’ve designed like a custom panel that all my women are getting that are whether. Hopefully before they’ve started their fertility journey or if they’re in the middle of it, we’ll do the women’s health panel with Inte X. ’cause it’s very targeted at exactly what a woman needs to know about her mitochondria, about her hormones about mitochondrial dysfunction, about nutrients.

So it’s very targeted exactly what that person needs. What’s your favorite prenatal vitamin? My wife has taken the plus one from Metagenics. Okay. [00:45:00] Yeah I know there’s a lot of good ones out there. I don’t even know why, honestly, that’s just one historically that I was introduced to many years ago.

And yeah,

Dr. Weitz: one thing it has is extra L-carnitine, which can be very helpful and I think mitochondrial support often overlooked. Yeah. Do you have one that you like? I’ve been toying with different ones. We’ve been using the Designs for Health one, but it’s hard to find the perfect one and we always have to add stuff to it

Dr. Kozlowski: That’s exactly kind of what we’re, because my wife is actively pregnant right now.  She’s doing plus one, and then we’re optimizing it a little bit based on her genome, so Right. That I mean, I, we’re definitely in, in agreement there on that plan. I, you know, most of the good nutraceutical companies make a good product and it, you know, you kind of pick one that’s worked for you. I mean, we have the healthiest daughter in the world, so I don’t want to change anything.

So that’s what worked for us the first time and we’re sticking to it this time. Right.

Dr. Weitz: Good. [00:46:00]

Dr. Kozlowski: Yeah.

Dr. Weitz: You know, we’ve been talking a lot about women, but the role of men in fertility is super important and I think often overlooked.

Dr. Kozlowski: Yeah. Yeah, it’s typically right, we go straight to the woman. But yeah, I mean there’s a large percentage of the infertility stories that are related to men and that’s why with the genes specifically that I could mention that, that do have an association with male fertility.

I try to mention it ’cause it’s not just the women you know, for. The mechanism is basically the same for us as the environmental toxins are destroying our testes. And you know, when the testes are surrounded by toxins, we’re not gonna produce sperm as well, or the sper sperm we produce are not gonna be as modal.

Right. And so it, it’s. You know, if you do a genetic panel on a man and it’s like he does need more vitamin A, he does need methylation support, he does know need coq 10. And that’s again where genetics has kind of changed my life. Personally and with my patients. ’cause [00:47:00] I would typically say, well, you know, until there’s a problem, you know, it’s, again, I don’t fully, I guess, you know, if you have a micronutrient test, you can, you trust you can run that.

But for me, like, I would do the genetics and be like, well listen, like we are gonna get you on, you know, 200, 300 milligrams of coq 10, we are gonna put you on 10,000 units of vitamin A. ’cause your genetics are saying you need it and let’s optimize your sperm. At the same time I, you know, if we do the genetics and the mitochondria at risk, then we know the sperm are at risk.

So let’s, that’s again, that’s getting you into, let’s get you on mitochondrial support, but most importantly, let’s protect your mitochondria. So the, I think luckily the mechanism is the same. And I, like I said, I think the biggest variable in all of this is our environment. So that’s where. Our genes have not changed, but our gene, we are more susceptible to these genes being activated because of our [00:48:00] environment, right?

Our mitochondria weren’t as risk the way they used to be to the way they are now. How nobody’s ever come out

Dr. Weitz: with a men’s prenatal. I think that could be your product. There you go. Yeah. So, thanks Peter. This has been a good discussion. Thank you. What are your contacts for people?

Dr. Kozlowski: Yeah, so my website is the best way to get ahold of me doc cause.com.

I don’t do social media. That’s for my own mental health. So, but I have been I do podcasts pretty frequently, so just. Googling my name. There, there’s lots of podcasts that show up. So there’s, I have a couple videos I’ve made on my website but really through just doc cause.com.

My books are on Amazon and everywhere. They’re, so that, that’s the best way. And what

Dr. Weitz: about that AI platform you’re working on?

Dr. Kozlowski: Yeah, so that currently is, designed for practitioners. So if there’s practitioners okay. That are learning how to optimize [00:49:00] applying functional medicine, right, or integrative medicine.

That’s really what my AI agent has been designed to do. I mean, is it currently available? It is. So the website is rcpp ai.com, but there’s a direct link from.cause.com. So, okay. You can sign up and really. The way it’s designed is so that if you have a new practitioner that’s like, I’ve never tested someone’s glyphosate levels before.

I’ve never done an organic acid test before. I’ve never done a microbiome test. You can, you know, type, and that’s the more advanced, I mean, you can type in my patient’s or ribose levels where 105 on their oat, what does that mean? Or their glyphosate levels were this, what does that mean? And then how do I treat it?

So I have. All my protocols in there of how to detox things, how to treat SIBO and mold. And I just think that there’s so many practitioners now that want to get into functional medicine. They’re in the middle of a practice. They go to a conference for a weekend, and then they, you know, try to apply it and it’s very hard.

So, right. [00:50:00] I train my, and then traditional AI is just not trained. The knowledge base is not. Up to date with functional medicine so that I used my books and everything I’ve learned over 13 years to train my own agent. So that’s available. Yeah, it’s through my website. It’s, I’m very excited about it.  It’s so yeah, people can go on there and use it.

Dr. Weitz: Sounds great, Peter. Thank you so much.

Dr. Kozlowski:  Thank you for having me.

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Dr. Weitz:   Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review.  As you may know. I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and want to promote longevity. Please call my Santa Monica Weitz Sports chiropractic and nutrition office at 310-395-3111 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Mike Feldstein discusses Indoor Air Quality and How to Improve It with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

Improving Indoor Air Quality for Better Health with Mike Feldstein
In this episode of the Rational Wellness Podcast, Dr. Ben Weitz discusses indoor air quality with Mike Feldstein, founder of Jaspr. Mike shares his journey from wildfire and mold restoration to developing a high-quality, quiet air scrubber designed for home use. They explore the impact of poor indoor air quality on health, the limitations of standard air purifiers, and practical tips for improving air quality at home. Mike highlights the importance of clean air, particularly in bedrooms, and offers insights into air filtration, mold detection, and the prevalence of microplastics. The episode emphasizes the need for greater air awareness in the wellness space and introduces Jaspr’s advanced air scrubber as a comprehensive solution.
00:00 Introduction to the Rational Wellness Podcast
00:26 Meet Mike Feldstein: Air Quality Expert
01:37 The Importance of Air Quality
06:09 Challenges in Indoor Air Quality
08:17 Wildfire Impact on Air Quality
14:17 Mold and Indoor Air Quality
24:02 Healthy Homes and Air Filtration
26:46 Cooking and Air Quality
27:30 Wildfire Smoke and Indoor Air Quality
28:11 Range Hood Efficiency Test
29:07 HVAC Systems and Air Circulation
31:33 Microplastics in Indoor Air
34:17 Sources of Microplastics
37:49 Impact of Pets on Indoor Air Quality
39:48 Optimizing Bedroom Air Quality
43:06 Jaspr Air Purifier Features
48:32 Special Offer and Conclusion
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Mike Feldstein is the founder of Jaspr, a high quality air scrubber, and an air quality expert. With a background in wildfire restoration, air quality consulting, and home remediation during some of the biggest natural disasters, Mike started Jaspr to innovate in air science and technology. His goal is to protect air quality and improve human health using the latest air quality science.  You can learn more by going to Jaspr.co.  The cost of Jaspr is normally $1199, but if you use the discount code WEITZ for the next 2 weeks it will only be $799. 

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Today I am excited to be having a discussion about indoor air quality with Mike Feldstein.  I believe this is the first detailed discussion we’ve had on this podcast about indoor air quality. Mike Feldstein is the founder of Jaspr, which is a high quality air scrubber, and Mike is an air quality expert. He has a background in wildfire restoration, which is especially significant to those of us living in Los Angeles in 2025. And he was also involved with air quality consult consulting, home remediation during some of the world’s biggest natural disasters.  Mike started Jaspr to innovate in air science and technology. And his goal is to protect air quality and improve human health using the latest air quality science. Mike, thank you so much for joining us.

Mike:  Thanks for having me, man. I’m excited to talk all things air with you.

Dr. Weitz:  So I guess you’re an airhead.

Mike:  Air snob, air snob.

Dr. Weitz:  There you go. Perhaps you can tell us what you were doing for a living and how you became interested in air quality.

Mike:  Yeah, so it’s kind of twofold. The big one was, my background was in wildfire flood and mold restoration. So we weren’t doing it locally, we were traveling. So anywhere where the biggest disaster was in North America, that’s where we were going.  So California wildfires, hurricane Harvey, Canadian wildfires, floods, hailstorms, all that kind of stuff. So it was like really disaster response restoration. And the main thing that you do when you’re remediating anything is you have to clean the surfaces and the air. People think about mold removal, but visually you only think mold remediation has like removing the mold.  But that’s not the case when you remove mold. You’re isolating the environment, you’re removing the physical materials and you’re scrubbing the air inside and outside. So a lot of restoration and environmental cleanup, it’s equal parts air as it is surface cleaning. And we would use these big machines called air scrubbers.  They were huge, loud, they kind it like, like this, like big subwoofer looking things. Very loud, very industrial, but they clean the air incredibly well and. When I started comparing that to air purifiers that you would find out like a big what Walmart Best Buy, home Depot. What people imagine when they think about an air purifier are the scrubber specs versus the purifier specs was almost like 20 to one, and I’m like.

This doesn’t really make much sense because people are buying air purifiers for wildfire smoke all the time, and it’s way too small to get the job done. An analogy I like to use for people is it’s like trying to heat your bathtub with a kettle, using a little air purifier to try to clean your air. It’s tea.  A kettle is fantastic if you’re trying to make a pot of tea, but you cannot heat your bathtub with a kettle because it’s gonna be cooling down faster than you can possibly heat it up. So the. I, and it was frustrating because we would remediate a home after wildfire or smoke, detox it, clean it three weeks later, it would be contaminated again, because often the ambient outdoor environments after a disaster would stay bad for months.

So I’m like, okay, where can I find a. Beautiful air scrubber, a quiet air scrubber that people could leave in their homes [00:04:00] regularly, that wouldn’t sound like a truck, and they didn’t exist. So that’s when I realized that, okay, there’s lots of remediation and restoration companies, but how can there possibly be no product that works like a scrubber, but that is also quiet and beautiful?

So that kind of changed my path from all things restoration to just completely focusing on air. And then the other side of that was when we would, in between disasters, we would do air consulting. So if somebody was sick at home and they didn’t know why, we would come to their home and test everything to figure out if something might be lingering in their environment that’s keeping them sick.  And people generally, water and air and EMF and everything, it’s the normal is not good. So I kind of just. I realized that a lot of people are quite water aware, they’re diet aware, they’re movement aware, but air awareness relative to all these other big health inputs was completely un. You know, it wasn’t getting the time and attention that it needs.  And I started seeing people have a huge be health benefits by improving their air. So I went all in.

Dr. Weitz: It’s definitely the case that those of us in the wellness community are really focused on the food we eat, the what we drink, the water, the pure purity of that. And we focus much less on the air, but yet we breathe a lot more air than we eat food or drink water.

Mike: Yeah. So, to put it into perspective for people. The average person, let’s say, eats two pounds of food a day, two or three pounds of food, drinks a gallon or so of water. But you can, you breathe up to 17,000 liters of air. You can go three weeks without food, three days without water, and only three minutes without air.  Air is the first thing breathing. It’s funny with food, we talk more about the food that than we eat than how we eat it. We talk about the water, not how we drink it, but breath work and breathing gets a lot more conversation. This breath and breathing [00:06:00] gets a lot of attention while we’re ignoring the actual air that we’re breathing.  The air is the fuel that you’re breathing and people are completely ignoring their fuel source.

Dr. Weitz: So what are some of the biggest issues with indoor air quality? And I say this here in Santa Monica, California, right next to Pacific Palisades where we had these horrific fires. And I imagine the stuff being spewed into the air is probably not over.  ’cause first you got the fires, then you got, they’re quite, in a way, they’re digging out the soil. And then we’re gonna have all this massive construction happening soon here.

Mike: So the big picture, the issue is. Roughly since the seventies, homes have been optimized to be airtight boxes, so they’re incredibly tight.  They’re built to be energy efficient, keep the cool in, in the summer, keep the warm air, and in the winter. Now, if you think about a pond, if you think about a moving [00:07:00] stream or a current or a river, generally moving water. Clean water. Right? But when a stagnant pond, that’s where you get algae, bacteria, mosquitoes.  If you can imagine all the things that you see growing when water is stagnant. So outdoor air is free flowing. It’s like the lakes, it’s like the oceans. But we’ve built our homes. Basically our homes are little stagnant ponds. So because there’s no air movement in our homes, this is where everything starts to grow and starts to fester.  Plus, we spend like 95% of our times indoors on average. So there’s a reason why you don’t walk down the street and have mold problems, or have dust problems, or have VOC problems. These are indoor problems. Our homes are incredibly tight, and the greatest air purifier of all time is nature. The UV light from the sun, wind, rain trees, but we’ve trapped all that outside.

We’ve trapped ourselves inside, and then we have thousands of chemicals in our homes from the paints to the flooring, the adhesives, the fire retardants, cooking [00:08:00] pets, and it just can’t breathe. It has no airflow. So generally speaking, the problem is with how we build homes and how we live in a modern society.

That is causing all of these problems, especially like, and then in a wildfire setting, you are absolutely right. So you ha like people ha, when you test the air quality and water quality and soil quality, it can stay bad for a very long time after a fire. And the recent LA fires in January are unique, like one I’ve never seen before because I’ve never seen that many homes burnt in that concentration.

But also. That many electric cars. So I’m very curious like what happens when you burn four, 5,000 lithium batteries? We know, and everyone’s been at a campfire where someone throws the bag of marshmallows in and they’re like, that even looks and feels very toxic. So now imagine scaling that up to like a billion x when you have everything in every home that burnt every can of paint.  The [00:09:00] walls, the floors, the furniture, the chemicals, the cleaning products, the cars, their batteries. So it’s a very toxic soup. And then, yeah, so you have all that, of course, that gets in the soil and it gets in the water, and then every time that the wind blows, the ash kicks up more and more.  And then, yeah, then you’ll have your rebuild phase. It’s a pretty big deal.  

Dr. Weitz: I know every day I would go out to my car after the fires and it would just be covered in soot and then you just think, oh my God, how much of that is getting into my lungs?

Mike: A lot. And it’s a tough situation because, and like a lot of people in LA, because the city is so vast, a lot of homes, it was unclear the amount of damage because.  A lot of you go into your home, and if you don’t. See piles of ash everywhere. You just figure, my home’s fine. Its smelled smoky a couple weeks ago. It’s all good now, but it doesn’t really work that [00:10:00] way. Be if you test anybody who didn’t detox their home in la now if you test their carpets, their couches, their bedding for hexavalent chromium, or polycyclic aromatic hydrocarbons or heavy metals.  If you don’t detox it and pull it out, just think about our bodies, how many years we can hold heavy metals and things if we don’t detox it out. So every porous material in your home is the exact same, and a lot of people don’t remediate and detox their homes because they don’t realize that they need to.

Dr. Weitz: Can you even detox that stuff out? Do you have to just throw out everything that’s porous? The poor stuff is pretty hard to deal with. You’re talking about mattresses and carpets and furniture and stuff, so it depends like

Mike: which way the wind was blowing your proximity to the fire. So that’s why TE testing can be a decent idea for people.  Also, depends if people had good air filtration in their homes beforehand. So. If somebody had significant air filtration in their home, [00:11:00] then likely most of those particulates were being captured before they had a chance to settle on surfaces. But typically, all of the hard surfaces can be cleaned up, but the soft surfaces would be replaced.  But it’s not black and white at all. Actually created on YouTube. Oh, yeah we put it on YouTube recently. If people look on our YouTube and type in like Jasper Smoke course it used to be. Like an email thing, but now it’s just totally free and it’s on YouTube. So after the fire is up, I was chatting with everybody like an hour, several hours a night about their unique situation and 99% of those conversations was, were the exact same.  So I just created a bunch of videos on how to assess your own home, do you, should you go with insurance, how to vet your contractors, how to detox your own home. All that kind of stuff. So people want, if anyone wants to dive deeper into smoke detox, it’s all available on YouTube.

Dr. Weitz: Interesting. And then and then I guess after all that, then detox your body as well [00:12:00] that I don’t

Mike: have experience in, but that’s absolutely a good idea.

You, you’d be the guy for that. Yeah. And if you think about it, like when a lot of people are sick at home, the their aha air moment. Often occurs when they go on a trip or they go camping and then they feel great and then they come home and they’re sick again. And they have this moment, is my home making me sick?

So if you’re not optimizing for the, like your home, that’s your fish tank. And if you think about how would you clean a swimming pool, you use a water filter. You don’t jump in the pool and use a sponge and scrub the sides. You need to filter the water constantly, right? And. In a home, people are spending a lot of time and energy and money on mopping and vacuuming and wiping counters, and that’s all great.

But if you don’t, if you don’t also have a strategy in place to filter your air, you’re just that. You’re just in the swimming pool, scrubbing the sides and not filtering the water. And [00:13:00] guess what happens if you don’t filter that pool of water? It turns green real fast, so people’s indoor air, you cannot see it.

Most of the time, but wow. When we test air, it’s usually off the charts. Typically, we see indoor air that’s five to 10 times dirtier than outdoor air.

Dr. Weitz: So how do you find somebody, what’s the best way to test the inside of your house? You have to have an expert come in and test it. Do they? How do you know?

Mike: You know, so I used to be, that’s what I used to do. Okay. And I can’t tell you a time when I’d ever go into a home where if I tested someone’s air or water, that it was good. Like it just isn’t. Okay. Indoor air is pretty much always bad, so the practical way to test, there’s a few things to look for, but a pr a practical thing, like you could go and pay $1,500 or more for an expert to come into your home, but, and I was that guy, but I did not feel good because the 80 20 like.  They would’ve been better [00:14:00] off just getting the solutions.

Dr. Weitz: Okay.

Mike: Because, you know, just assume your home is toxic. If you want to verify it. And depending on people’s budgets and everything, like if you test your home for mold, indoor and outdoor, there’s always mold. I always tell people, if you ever wanna break a lease, call me.  I’ll come over and I’ll find the mold. 

Dr. Weitz: Well, you need to talk about that a little more because mold’s a big topic in the functional medicine world and we talk a lot about testing your home for mold, testing the body for mold, and there’s a lot of controversy. Oh no, this test is not accurate. It’s showing mold and maybe you don’t really have mold, but I’ve heard you say before, and you just said here, that pretty much everybody has some degree of mold in their home.

Mike: And in their body, like when have you ever done a test and seen zeros? That’s not how it works. It’s,

Dr. Weitz: well, you know, it’s interesting. I think that makes sense because mold is an important constituent of the environment. In fact, it’s in the soil, you know, just like bacteria are. And the goal is not to [00:15:00] rid ourselves of all bacteria and all fungi.

Mike: Yeah, exactly. Yeah. People know what happens if you take too much antibiotics, like you kill your immune system, right? So yeah, it’s, people got this idea that like mold is the big enemy. The problem is you’re, if you think about that piece, that sandwich. Out on the counter, not so bad. You put it in the Tupperware, it starts growing mold, and your home is essentially a big Tupperware box.  So you have mold issues because if you live in a airtight home with no ventilation and no filtration, that’s the real problem here. So typically when you do test for mold indoors, you always want to test outside and you want to test inside. And if you don’t test outside, the test is completely useless.

Because that’s your control sample. So if it rained there, could the spore count is gonna be incredibly high inside and outside. Your indoor air comes from outside. So [00:16:00] if people have a noticeable odor in their home, it smells musty. Or if they’ve had water damage, if they’ve had leaks. Like if you have visible mold in your home, that is a time when you want to get restoration and remediation done.

If it smells really strong of must and mold, that’s when you may want to go and look for it. But I’ve seen a lot of people who, I call it whacka mold because they’re just looking all over, you know, they’re dealing with a little leak here and a little thing there, and they’re cutting open this wall.

Next thing you know, it’s like investigative surgery of your home. And then, you know, next thing you know, you’re living in another home for six months or 12 months and you’re displaced and it costs a fortune. And a lot of people like it’s not a black and white situation. And when I hear people talking about it, it’s like, I’ve got the mold like.

If you take a thousand people and you test everybody’s home and bodies for mold, everybody has some amount of mold. It’s more about like what concentration, what species, and technically you’re not even supposed to [00:17:00] test for mold if it’s rained within two or three days. I can’t remember if it’s 48 or 72 hours.

Nobody, no mold testing company in the world that I’ve ever encountered upholds that standard. How could you imagine on a it, it drizzles that morning you canceled the job. You still have to pay your employees. The customer’s not gonna want to pay you to not come, right? So nobody does that. You just take your control sample inside and outside, but it can dramatically skew results.

But more or less, if you’re living in a really tight home, the VOCs from your furnitures and the paints and the off gassing and the cooking and the mold is a big problem. So it’s not that mo mold does make a lot of people sick, but you could have five people living in a home. Two are sick. One is moderately sick and two are completely fine because people you know, they detox differently and they ha have different severities of allergies to things.

I honestly treat mold not so differently than pollen. Like someone could have their life. [00:18:00] Wrecked havoc from excessive pollen and someone else won’t notice a thing. And I find mold to be very much like that, where for some people it’s a big problem. For others it’s not. But to me, like I preferred filtered water.

My water budget is huge. We get glass bottles of water delivered every couple weeks, like. For me, air and water were like my first two. ’cause those are the two things that I need to survive the most. Right? If I can only live three minutes without air, clearly it’s quite important to me. If I can only live a few days without water, also important.  So where a lot of people are starting from supplements and then food, and then water, and then air. I’ve kind of flipped it a little bit where I’m dealing with the thing that I consume the most of and then branching up from that place.

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Dr. Weitz: I’ve really been enjoying this discussion, but I just want to take a few minutes to tell you about a product that I’m very excited about.  Imagine a device that can help you manage stress, improve your sleep, and boost your focus. All without any effort on your part. The Apollo wearable is designed to just to do just that, created by neuroscientists and physicians. This innovative device uses gentle vibrations to activate your parasympathetic nervous system, helping you feel calmer, more focused, and better rested.  Among the compelling reasons to use the Apollo wearable are that users experience a 40% reduction in stress and anxiety. Patients feel that they can sleep. Their sleep improves up to additional 30 minutes of sleep per night. It helps you to boost your focus and concentration and it’s scientifically backed.  And the best part is you can get all these benefits with a special $40 discount by using the promo code weitz. W-E-I-T-Z, my last name at checkout to enjoy these savings. So go to Apollo Neuro and use the promo code Weitz today. And now back to our discussion.

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Dr. Weitz:  What is the best way if somebody wants to test their home for mold to do it so it’s accurate?

Mike: It’s tough too. So there’s multiple different tests and some skew positive and some skew negative. I mean, there’s the Petri dishes.

Dr. Weitz: We have the IMI test. Is there? Is there? You got the

Mike: aerosols? Yeah. IMI basically is restoration. Companies love IMI because it’s designed to be generally quite alarmist. So with an imi, it’s testing your dust, right?

There was obviously mold at some point in your air, so even if there’s not mold. Today, a lot of it, there was some mold that passed through. So [00:21:00] you test take a dust sample and it’s generally like a, it’s designed to be a fairly alarming test, even the way that the report is kind of designed. It’s a perfect thing for restoration companies.

I’m just looking at financial incentives for restoration. Companies love it because it’s always gonna get the insurance company to approve a reclean. So if Derby’s not the best test, what is the best test? Well, it’s not that. It’s, the thing is it’s a good tool also. Okay. Okay. So if, so, and like, it’s not that it’s a ba and aerosols can also skew negative ’cause they’re just looking at the exact moment of time.

Right. So,

Dr. Weitz: you know, the, so use the Ermi test, but don’t exaggerate the results. The best test

Mike: of all is like the best. If we’re going from best to worst, it’s the, it’s like a mold dog. A mold sniffing dog, you’ll find exactly where the mold is. You can’t beat that. But like once I had tested hundreds of homes for mold, for example.

I, I didn’t really need to do testing anymore [00:22:00] because you can feel it, you can feel it in your lungs immediately. You could between smell, difficulty of breathing in my lungs, I could go into a home. Most people who do indoor environmental testing, they know in the first two or three minutes just ’cause their body tells them what’s going on.

And then the data is just to quantify that for the homeowner or for the patient, like. Your body really knows if, but I mean, mine is more calibrated because I’ve tested a lot before, but I still I like the aerosol test. I also like the imi. It’s a tough one. It’s really, it really depends also if someone has cancer and money.

Just saying like they, they have a severe health issue and a large budget. I would definitely bring in a company to do testing, but that’s not the, so you kind of need to find the balance. Like anything with health, like health isn’t free, so it’s a little bit nuanced to, to give blanket advice is a little bit difficult.

Is

Dr. Weitz: there any benefit to the Petri dishes? [00:23:00]

Mike: If so, when I used to do the Petri dishes, we were supposed to. Get the p like we would do the Petri dish and then instantly give it to the lab and they would culture it in the lab environment. If you kind of let it sit in your home environment pretty much always grows mold mo unless you’re filtering your air.  So like that, like, and that’s really like, or really good ventilation, so that’s why older homes often. Can be good because they’re leaky or new homes are incredibly tight. So people, when I was doing air testing, almost half of the testing work that we were doing was people who just moved into a brand new home because the, it was so tight that it would have humidity issues and off gassing and VOC issues basically right away.  And the problem is. Like the architect and the builder aren’t typically sitting around saying, how do we make the healthiest home for people? Like, [00:24:00] you know, you buy a home. Why?

Dr. Weitz: Why isn’t somebody doing that? Why isn’t somebody saying, we, here’s a design that allows a home to breathe and this is gonna be healthier for you.

So

Mike: on the custom home level, they exist. So if you Google Healthy Home Builder, there’s a handful per city and it’s a growing trend that I believe strongly in using better materials, using better hvac, you know, mold resistant, no off-gassing low VOC, a good ERV system, which basically is a fresh air intake so your home can actually breathe better.  While maintaining its energy efficiency, but if you think about it, when someone typically buys a home, they’ll go get a home inspection and all that home inspection is looking for is there anything in the home that is gonna cost me money? How’s the roof age? How old’s the water heater? Is there cracks in the foundation?

Typically, there’s no prior to that process that says, is this a healthy home for my family to live in? And that’s why, that’s [00:25:00] where the air awareness is more important than any product anybody can create. Because once you start asking the questions, you’re able to kind of navigate and advocate for yourself.

But I’m really. Expecting to see a trend here where we see healthy homes and going beyond custom homes to the developer level. Unfortunately now, the, it used to be clean living and now the term wellness has really got hijacked. Wellness now means like often very edge case biohacking tools, whereas it used to mean like.

Go clean water, clean air, clean diet, go for a walk after your meals, get some sunshine. Go for like, it used to be about healthy living. And then on top of that, how do we layer in our exer, our exercise, our strength training, our supplement, it’s literally called supplements. It’s supposed to be the extra thing to balance you out, but it’s become the.

Pill like people have started to lean on pills, has the primary thing [00:26:00] as opposed to a supplementary thing, and unfortunately until the homeowner and the consumer is made aware, there is no value actually put on. A healthy home, right? The consumer’s not valuing it yet, so therefore neither is the builder, neither is the architect.

It’s, they just wanna say, how fast can we build a home? How many square feet? How cheap do we have? A two garages, you know, if people are looking for a whirlpool and things like that, they’re looking for features, right? Instead of just a home that has great air, great water, really good lighting, right? I feel the movement coming in this direction it just, it takes one breath and one conversation at a time.

Right. And that’s what we’re, that’s what we’re trying to do here.

Dr. Weitz: So how does cooking affect air quality? And I heard you speak about some of the issues even with the range hoods.

Mike: That’s perfect. So we’ll talk cooking and I’ll talk just like I like giving people a bag of tricks, [00:27:00] free tips that they can implement immediately that doesn’t require buying anything at all.  So, but to cooking is a big problem because the way your home is. Built so tight. When you cook, a few things happen. And it doesn’t matter if you’re just, if you’re cooking bacon, you could be making grass fed steak with organic oil and no seed oils and still be heavily polluting your air. So when you take high heat and protein, that creates something called polycyclic air magic aromatic hydrocarbons.

And that’s a cancer causing. Compound that we would test for after wildfire smoke. That was one of the most common things that we would test for. So high heat and protein gonna be a big problem. The particulate themselves, the actual PM 2.5 that gets off gassed is another issue. Then obviously a lot of people also have, gas ranges and most range hoods don’t work. So if the ventilation is working good, we have no problem. Commercial kitchens [00:28:00] tend to have really good range hoods in a in a home environment. There’s a few problems. Number one, they’re typically too high, they’re not powerful enough, and they’re not vented properly.

So, this is the one thing that everybody should do. Take your take a tissue. Hold it up to your range hood and put it on fan speed, one or two and make sure it’s actually sucking it up and pulling it up. 50 50. It doesn’t, so if it’s not even pulling up a tissue, it’s not even bring, it’s not intaking any air.

So that’s the first thing. Then two, check where it’s venting. So a lot of the time it’s venting up into the cabinet. Just above, it’s not going outside. And the whole point of ventilation is to vent outside. So you want to, you want a range hood that can hold up a tissue. You want a range hood that vents outside.

And then ideally, if you can, if you’re like boiling or simmering use the back burners [00:29:00] instead of the front burner, because the back burner captures a lot more particulate than the front burner. And what happens when you cook. It’s not just a localized issue. For example, if you take a 3000 square foot home and you know, Jasper can detect the air in real time.

So if I have a Jasper in my baby’s bedroom and I’m

Dr. Weitz: so, so just for everybody, Jasper is the air purifier that you developed and it also gives you some reading as to the quality of the air, correct?

Mike: Yeah, so it’s reading the particulates in real time. And adjusting its fan speed accordingly. So even if Jasper is in your baby’s bedroom and you’re cooking in the kitchen on the opposite side of the house, within a minute or two, Jasper’s gonna be detecting the poor air quality in the bedroom in every room because you have an HVAC system that’s designed to circulate and mix the air.  So you think of the, like when you walk into someone’s home who’s cooking, you [00:30:00] smell it right away and you smell it because it’s everywhere. And then just like the wildfire smoke we were talking about before, it gets absorbed into the couches, into the chairs, into the clothing, into the all the poorest materials.

So if people have a rangehood that’s not working and the weather permits regardless, like I open my windows big time when I’m cooking. Because you really just don’t want to be offgassing heavily in your home. And then on top of that, I would do the same tissue test in your bathroom. So make sure your bathroom fans can also hold up a Kleenex or a paper towel or something like that.

And then you should check to make sure your bathroom fans are venting outside. A lot of people’s bathroom fans vent directly in the attic. And then of course they have moldy attics because they, if you have a family of four, taking four showers a day, you’re dumping gallons of water into your attic. And of course you’re gonna have mold for sure.

And then, yeah, filtration really helps too. So the way Jasper works is it’s gonna automatically [00:31:00] respond to any cooking in any particulates, so that way it’s silent. You’ll have your green light on, you’ll see a low number, like a four or five. Which is, and we’re looking at PM 2.5, and those are the particles that are small enough to enter your lungs and your bloodstream.

So if we measure the air in a home with no filtration and we cook, the air quality can stay elevated for three or four days, and by that point it’s been absorbed in all your materials. If you have a jas, a couple Jaspers in the home, within 20 minutes, we’re back down to baseline. So it’s a huge difference between filtering your air and not filtering your air.

Right.

Dr. Weitz: What about microplastics? Because there’s been a lot of talk about microplastics and we know that they end up in our brains, but they’re also in our lungs.

Mike: Yeah. So there was a study done in London where they tested a hundred homes and 98% of all samples contained microplastics in them and indoor environments had up to 40 times more microplastics than [00:32:00] outside.

Wow. So. And then they started to work with a lab that was doing biopsies on people’s lung tissue, and almost a hundred, I think a hundred percent of all the lungs that were tested had microplastics in them. Wow. So they say that the humans that live in cities on average are breathing one credit card worth of microplastics per week.

That’s insane. And how does this happen? So you have things like plastic manufacturing, just general plastic breakdown when things decompose over time. They decompose often into the air. If you think about a car, you have to change your tires every few years. The rubber wears thin, like where do you think the rubber goes?

All this stuff goes airborne. And then inhalation is the primary exposure route for microplastics. So it’s kind of interesting that people are thinking about the microplastics in their water. But there’s a very good argument to be made that you could be breathing way more plastics microplastics than you are drinking them.

[00:33:00] So we did a study about two months ago. We contacted the lab and we said, Hey, can we do a microplastic study to show how Jasper, is Jasper effective for microplastics? If so, how effective? And they said, there’s not an exactly a microplastics test because, they’re all different sizes. So they said we can do a latex bead test where they have these microscopic latex beads that they aerosolize that are the size of some of the most common microplastics, and we removed 98% of all of them in one hour.

So the good news here is your indoor, it’s like a good news, bad news. Your indoor air is way worse. Then your outdoor air across the board when it comes to microplastics, mold, dust, even pollen, we get way more pollen inside our homes than outside because it gets trapped in there and it can’t get out. The good news is if you filter your air, it’s not a problem anymore.

So you can turn like, you know, you can’t heal in the place that made you sick, and you can turn this negative that’s making [00:34:00] you sick into a clean air sanctuary. So instead of saying, let me go outside and get a breath of fresh air, how about let me go inside and get a breath of clean air so you can really turn this around very cost

Dr. Weitz: effectively.

Where are all these microplastics in our home actually coming from?

Mike: So, like I said, it’s the plastic manufacturer. It’s out, it’s mostly outdoor sources. Oh, okay. Because our indoor air comes from the outdoor air. So it’s, right. It’s like, it’s the rubber from the tires, it’s the factories. It’s all that stuff.  It’s the plastic products in your home are slowly decaying and decomposing over time. Also a reason why you don’t wanna live near a freeway. It’s a good idea. I actually, when I have tested air by highways, it’s always been less bad than I expected it to be, huh? When it is bad is during Russia like bumper to bumper traffic.

Freeways are bad, like highly congested. Freeways are bad, but freeways that don’t have a lot of traffic that are constantly flowing are much less bad. Okay, because you [00:35:00] don’t have like thousands of cars in one small area constantly running their fumes. So. And there’s also even debates now that plastic kettles could be released.

Like, like things that heat up water in your home could also be aerosolizing like, to me, that makes sense. I can’t say I’ve seen a test on it, but if you think about a plastic kettle with boiling water against plastic, if you can get microplastic we know that we can get microplastics in our food and in our water.

In our water bottles and our Tupperware. So if you think about anything that, that has high heat and plastics and the sun is constantly breaking things down, and then when it breaks down, they go airborne. I

Dr. Weitz: was just reading an article about how a lot of black plastic utensils like you use you know, in the kitchen because they’re made from recycled plastic, that plastic has toxic material from computers or whatever else that gets into it.  And so then that breaks [00:36:00] down.

Mike: Yeah, it makes sense. Like if that, and also if that plastic is touching the high heat, right? Like when you look at that spatula over time, it’s like, it’s smaller. It’s that edge kind of comes down a little bit. It’s like where did it go? So the interesting thing was in London, 100% of homes tested and they would test the dust sample and every single dust sample had microplastics in it.

’cause dust is a collection of things. It’s not just one thing. And a good way to know if you have an indoor air problem. The best way is do you have dust? If you have, does everybody have dust? No.

Dr. Weitz: No. I have no dust that’s just because you dust every day or you’d seen dust ever accumulate No where?

Mike: Well,

Dr. Weitz: think about this

Mike: if you have dust on a coffee table, okay? Did the dust come emerging from the coffee table or did it come from your air? Right? So you’re saying

Dr. Weitz: if your air is clean, you won’t have dust.

Mike: Yeah, of course not. If you filter the air, if you filter the dust from the air, then it [00:37:00] doesn’t land on surfaces because you capture it before it actually lands.

I thought dust,

Dr. Weitz: it was coming off your skin and your pets and everything else, and it just lands there.

Mike: Well, think about it. It can even, it can be on the dustiest place could often be your, the door cells your doorframes and your window sills, places that are actually above your body. So it’s not like it’s just falling off of you on the floor.

I see. The stuff that falls off you is very light, so it gets mixed into your air system very quickly. I see. So it’s all about the air. It dust is. Yeah, like it, it is, dust can be pollen. It’s mold, it’s allergens, it’s the pollution, it’s the VOCs. It’s a combination of all of the things.

And then dust creates a really good vessel for mold spores to hit your ride around your home. Great.

Dr. Weitz: What about pets? I’ve heard you talk about pets not being great for indoor air.

Mike: Pets are also a problem. Yeah. Well, think about this, especially like everybody I know who has a dog [00:38:00] also sleeps with their dog.

So if you think about it, could you ever imagine taking a blanket, going outside with it, rubbing it along? Your neighbor’s glyphosate filled lawn, maybe on some other dog butts, rubbing it on some trees across the road. Then bring it inside and shake it out in your bed. It seems like a crazy idea, but that’s literally most people’s experience every day when you have a dog.

Plus of course you have the pet dander. So yeah, you get all that stuff coming from outside. The pet dander itself. Dogs do contribute to humidity as well. And then cats have two, two issues. They also have allergens, but cat litter can also create a huge problem. If you look at what’s in cat litter, it is not good at all.

And so it, it’s all kind of cumulative, right? Like no. One of the things that we talked about here is gonna be a make or break, but it’s when you have an airtight home with no [00:39:00] ventilation, no filtration, it has cooking, it has pets, it has the allergens. That is a perfect storm for poor health.

Most people nowadays, we’re not ventilating our homes and we’re not filtering our air. So it’s just a constant accumulation over time. People and a lot of people wear their shoes inside, so that brings everything from outside as well. So the pets are definitely an issue, especially if people are allergic to pets.

Dr. Weitz: Yeah, I think I heard you say that there’s like 99% likelihood you’re gonna have fecal matter on your shoes.

Mike: 95% of all shoes tested at fecal matter on them. Wow, because like you go outside and dog shit outside, like it’s not surprising. But the cool, the coolest thing is where to, you know, make it tangible and practical.

The number one place to optimize for by far is your bedroom. Like if you spend one third of your life where you sleep, one third of your life [00:40:00] where you work, and kind of one third miscellaneous out and about taking care of those two thirds. Is very practical and that doesn’t require, you know, it’s very easy with health stuff to get super overwhelmed and you feel like it’s impossible and it’s this big rabbit hole, but it doesn’t have to be that way.

So like I, I just put sleep above everything else. And then what are the ingredients for a good night’s sleep? You need a good bed. Cool clean air. So everybody, thermal comfort is like humans optimize for thermal comfort over everything else. So the cool air is really important, even if that’s moldy, dusty, pollen filled air, a lot of people don’t even notice that.

Fun fact, we did a sleep study last year where we gave 150 people, Jaspers, who were using Ora rings to track their sleep, and the average person slept 25 minutes more per night and 18% deeper sleep. Wow, that’s amazing. So when I go into a bedroom and I use my par, my [00:41:00] particle, like my commercial grade particle counter, let’s say there’s typically a million particles floating around of all sizes.

When we put Jasper in someone’s bedroom within 20, 30 minutes, it’s 95% cleaner. Wow. And then it’s great. So I live in Austin and Jasper’s based in Austin. So whenever anyone buys a Jasper in Austin, we actually deliver it to their home and we test their air. So we go to their home, we go typically first.

Jasper’s gotta be in your bedroom. We do our particle counter, we turn the Jasper on, we talk for five or six minutes. By the time we, we leave their bedroom and to go into their main home, their first breath outside of their bedroom they find that it feels very heavy. Harder to breathe because it’s like if you were drinking tap water your whole life growing up it was just water.

You weren’t paying attention to it. And then if you start drinking filtered water, all of a sudden tap water tastes very chlorinated. You can taste the tap water now. It’s a big difference. That’s why I said I’m more of an air snob because once you start [00:42:00] breathing clean air, it becomes very annoying and difficult.

You go to, all of a sudden the sense and the heaviness is everywhere, but like. In a bedroom, good bed, good sheets, cool air, and clean air. If you sleep in air like that is the thing that you live inside of. So naturally, by cleaning up the environment, it has a profound impact on your sleep. And then when your sleep is good, sleep to me is synonymous with recovery.

So. A lot of people who struggle from seasonal allergies, they go from a lot of allergy attacks to none. People who snore, we’re doing a snore study in a couple months. A lot like my favorite, my, my sister here, literally like, we get this every week, but my sister, her husband’s John, he’s been snoring for five or six years.

Once they put Jasper in their bedroom, he stopped snoring. Now they’re not sleep divorced anymore. You know, John’s back in the bedroom. So it’s [00:43:00] really profound, honestly, the impacts that cleaning up your air in your bedroom can have on one’s life.

Dr. Weitz: How does Jasper work? What makes it better than other air purifiers?

Mike: So the big thing is the size, like. Most air purifiers that you see are made by billion dollar companies that make thousands of products. They make everything under the sun, so it was kind of just another box for them to check in the market, to throw it on Amazon and throw it at Walmart and call it good like.

Think, how crazy is it that the air people Google Air freshener more than air purifier? Everybody’s got an air freshener and all an air freshener is shooting chemicals out to hijack your ability to smell so you don’t smell the garbage anymore instead of just cleaning the air in Allers are toxic. Yeah, so like PE ins, it’s, instead of dealing with the problem, which is dirty air, they’re like, let’s just throw some more chemicals in there.

And that’d be a great way to solve the problem. Last week actually we just got back from our [00:44:00] first hotel trip in Miami. There’s a hotel there called the Caron Hotel, and they’re the first clean air hotel in the country. So they have a Jasper in every single guest suite and Oh wow. All 30 massage therapy rooms as well.

Huh. So if anyone’s in Miami and wants a good night’s sleep, I highly recommend that place. Back to your question though, about what makes it different, so. It’s really designed to be industrial, so it’s like what makes a pickup truck different from a sedan? You know, they both have four wheels, doors, a roof, an engine, but one can like pull a lot of stuff.

It can haul your boat, it can haul your trailer, and one’s just designed to. Haul, take a few people around town. So in, in its nature, Jasper is a lot larger. So it’s moving about five times the air of a traditional air purifier. Our filter is four and a half pounds. Most filters are about half a pound.

So our filter’s about nine to 10 times heavier ’cause we just have more filter media in there a lot. There’s the hepa, there’s the carbon. [00:45:00] So the filter’s just much, much bigger. When you look at most air purifiers, their filter looks like a tissue. It’s not much more than a piece of paper. Ours is like super heavy duty.

We make it outta steel instead of plastic. Going back to microplastics, PLAs polluting plastic. Is horrible for the environment. So to buy a machine that’s supposed to clean your air, that pollutes the environment, seems counterproductive to me. And then also, like the lifespan. So Jasper’s designed to last about 25 years.

Every component in there was designed by my restoration brain saying, how do we make like a restoration grade machine that I would use for mold removal, floods and hurricanes, but with the aesthetic and the design that people would want in their home. So when it’s more powerful. That means it’s more because it’s bigger, it’s very on, its lowest fan speed.

It’s virtually silent in a bedroom setting. You can turn it onto dark mode. It has no wifi, no Bluetooth, no EMF. So if you, the simplest way to think about Jasper is for [00:46:00] every one Jasper, you would need four or five small little machines, and it’d be very unpractical to put four or five little machines in each bedroom of your home.

So we just consolidated it and made, it’s like if there was. Big trucks and sedans, but no SUVs. We kind of have like the only SUV, and that’s why we call it an air scrubber because it’s really designed to be heavy duty, but also designed to be beautiful.

Dr. Weitz: It’s really amazing that it’s designed to last 25 years.

There’s not too many products that are designed to last 25 years. Your car is not designed to last 25 years.

Mike: Dude, I hate planned obsolescence, and I hate, and I hate planned obsolescence and I hate inflation. You’d think as we get more efficient and more productive and more technology, that prices would go down and we would build things to last longer.

But I think a lot of companies, you know, big public companies like. Quarterly revenue. They wanna sell more stuff every three months. Whereas I believe that if you just make a really great product that people can basically keep for a lifetime, [00:47:00] they’ll buy more of them. They’ll tell their friends. So the way our lifetime warranty works is if Jasper breaks.

We ship you a brand new one. You take the new one outta the box, you put the old one back in the box. We give you a prepaid shipping label that we email to you, and then we pay to send UPS to your front porch to pick it up off your doorstep because I can’t tell you how many times I had like a warranty on a product.

They wanted me to send photos, videos, original receipt, get an obscure shape box, go to FedEx and pay a hundred dollars to ship it back. And I just think that’s bullshit. I think if Jasper breaks, that’s Jasper’s problem. That’s Jasper’s fault, and I think it. It. I think companies should really put their money where their mouth is.

Like we don’t even have a sales department here. Everyone here who engages with customers was a former air quality expert, you know, been in thousands of homes. It’s the same people that are going to people’s homes every day. So we just view, we truly view Jasper as an air education company that happened to also make the world’s only air scrubber.[00:48:00]

Designed for your home. But that’s why 90% of what we’re doing is going to functional. Like right after this, in an hour from now, I’m going to a functional medicine clinic to teach them all about air and set them up with Jaspers because they’re detoxing people that are living in moldy, pollen filled environments.

So they’re doing great stuff, but they’re completely missing the most foundational part. So 90% of our time as a company is in education. And then because we only make one. Product it, it allows us to just offer a really good quality of service.

Dr. Weitz: So in order to order Jasper, is it jasper.com? Is that the website?

Mike: I wish it’s jasper.co.

Dr. Weitz: Oh, okay.

Mike: Dot co. And Jasper’s spelled JSPR.co. And ibel I’m seeing my,

Dr. Weitz: yeah I believe there’s a discount code that if our listeners and viewers put in code WEITZ, my last name, W-E-I-T-Z, they’ll get $400 off. [00:49:00]

Mike: Correct. So Jasper’s normally 1199 with your, with Code WEITZ, it’ll be $799.  And what we’re gonna do is, so starting today, the day that the podcast came out. For two weeks, it’ll be valid for $400 off. After that, we’ll leave the code live forever, but it’ll be $200 off. I just know myself as a consumer, I typically only buy things when there’s an opportunity to get a good deal.

So if. That’s also why we don’t sell on Amazon Best Buy or any of these big stores because they would take all the margin and we wouldn’t be able to give big discounts. So our whole philosophy is go speak to health conscious people, educate them as much as we can in an hour or so, give them the best price possible.

And so, yeah, so for the first two weeks, starting today, code WEITZ at JASPR.CO is $400 off. And then after two weeks from now, it’ll be $200 off forever. So, but if you feel so  called and you want to invest in your air, now’s a good time to do it now, one. You can only get one your bedroom a hundred percent, a thousand percent, take care of your clean air and the one in your bedroom.

You should really use fan speed two or fan speed three on dark mode, so you hit the light button so there’d be no ambient light. And it’ll be at a higher fan speed. So it’ll be a gentle white noise scrubbing your air constantly. And then if you’re putting one in your living room, you put that one on smart mode.  So it’s silent all the time, and that’s the one that will automatically adapt to any cooking and cleaning that you’re doing.

Dr. Weitz: So if you were gonna get two of ’em. Bedroom first. Yeah. Second would be the living room or would it be the kitchen?

Mike: So typically most homes, the living room and the kitchen are very close to each other.

Okay. Even though the polluting, polluting happens in the kitchen, it spreads throughout the whole home. So Jasper in your living room is gonna detect it in the kitchen like right away. Anyways, so the idea is you want to have the air [00:51:00] cleaning where you spend the most time. Right. So. That’s why a, a bedroom or a home office or a living space where the whole family’s hanging out in the evening, those are the places that you really want to take care of.

First and foremost.

Dr. Weitz: That’s great. We’re recording this podcast, but it’s gonna get it’s gonna get put up in about six weeks, so

Mike: Well, for everyone’s because we don’t know the exact day. That’s why I’m just saying today,

Dr. Weitz: right. From your perspective.

Mike: The podcast came out today. So yeah, I hope that resonates with someone.

And also, like I said, we don’t have a sales department. Everyone here is an air expert. So if you have any questions, Jasper or know Jasper about your indoor air, your environment, anything, hit us up on Instagram, send us an email. We are here to help. That’s great. Thank you so much, Mike. My pleasure, man.

Thanks for having me.

Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go [00:52:00] to Apple Podcast or Spotify and give us a five star ratings and review.

As you may know, I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and wanna promote longevity, please call my Santa Monica White Sports Chiropractic and Nutrition office at 3 1 0 3 9 5 3 1 1 1 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Dr. Tom Fabian discusses Measuring Bile Acids and Short Chain Fatty Acids with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

In this episode of the Rational Wellness Podcast, host Dr. Ben Weitz interviews Dr. Tom Fabian, an expert in microbiome science and a clinical education specialist at Diagnostic Solutions Lab. They discuss the new Stool Omics test—an advanced quantitative analysis of bile acids and short-chain fatty acids used in conjunction with the GI Map stool test. The discussion covers the clinical need for this test, the differences between commensals, opportunists, and pathogens, and how bile acids and fiber can impact gut health, motility, and inflammation. The episode also touches on dietary interventions, including fiber and polyphenols, and highlights the complexities of treating conditions like IBS and inflammatory bowel disease.
00:00 Introduction to the Rational Wellness Podcast
00:30 Meet Dr. Tom Fabian: Expert in Microbiome Science
00:54 Understanding the Stool Omics Test
01:21 The Importance of Discussing Gut Health
01:45 Clinical Need for the Stool Omics Test
03:05 Explaining Key Microbial Terms
04:40 Bile Acid Metabolism and Gut Health
07:35 Inflammation and Gut Health
11:10 Bile Acid Malabsorption and Its Effects
11:37 Biofilm and Bile Acid Malabsorption
13:08 Impact of Gallbladder Removal on Bile Regulation
14:51 Addressing SIBO and Dysbiosis
16:05 Role of Dietary Fiber in Gut Health
18:47 Introducing the Apollo Wearable
20:18 Different Forms of Fiber and Their Effects
21:21 Significance of LCA to DCA Ratio
25:13 Strategies for Managing Excess Bile
25:44 Understanding Bile Acid Malabsorption
27:20 The Role of Bile Acids in Gut Health
31:22 Exploring Short Chain Fatty Acids
33:20 Interpreting Stool Test Results
41:53 Balancing Fiber and Protein Intake
47:36 Case Studies and Practical Applications
49:30 Conclusion and Resources
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Dr. Tom Fabian is a Functional Medicine trained PhD, who serves as a clinical education specialist at Diagnostic Solutions Laboratory, which now offers the StoolOMX add on test to their GI Map stool test.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast. Welcome to the Rational Wellness Podcast.

I’m your host, Dr. Ben Weitz, and today we have the pleasure of speaking with Dr. Tom Fabian, a functional medicine training PhD, an expert in microbiome science. Tom serves as a clinical education specialist at Diagnostic Solutions Lab, the lab that provides the GI Map stool test that we use regularly in our office.  Today we’ll dive into a powerful new tool for gut health assessment, the Stool omics test, an advanced quantitative analysis of bile acids and short chain fatty acids, designed as an add-on to the GI map. Tom, welcome back.

Dr. Fabian: Thanks so much, Ben. Always a pleasure to be here. And thanks so much for inviting me back again.  Looking forward to the conversation.

Dr. Weitz: I love talking poop. It’s funny how patients come in and a lot of times they’re embarrassed talking about their poop, and I let them know. I talk about poop all day long and don’t feel embarrassed about it. It’s an important biomarker for overall health.  Absolutely. Why don’t we kick things off with the big picture? What clinical need inspired the development of this stool omics test?

Dr. Fabian: That’s a great question. So, as you can imagine with the typical comprehensive stool testing that’s available in functional medicine like [00:02:00] Gmap usually we’re targeting the most clinically relevant organisms, the ones that we know most about.  And so that gives you a window into a lot of these. Really actionable microbes when it comes to commensals pathogens, opportunists. But we also wanted to get a bit of a bigger picture. And there’s also growing research now on the products that they’re producing. So the research shows that it’s important to know not only which microbes are there, of course, pathogens versus opportunists versus commensals, and which commensals, which produce, which products like butyrate.  Ultimately, we want to know kind of at the end of that whole production process in terms of their gene expression and then their metabolic activity. What are they actually producing in the gut in terms of these key products, like short chain fatty acids, bile acids that have now been linked both to promoting health depending on the details and the levels as well as [00:03:00] linkage to a wide variety of chronic diseases and conditions as well as symptoms.

Dr. Weitz: Tom, just for those who might be lay persons who are listening to this podcast who are not functional medicine practitioners, could you just briefly explain what a commensal is? What an opportunist is, what a pathogen is?

Dr. Fabian: Absolutely. Yes. So of course pathogen is I think a lot of people are familiar with that.  Those are these microbes that can cause disease. Usually term as an infectious disease. In the gut. We know that there are a number of different microbes that can cause unpleasant symptoms, sometimes even very serious. For example, if there’s excessive diarrhea that can lead to dehydration there can also be certain microbes that can lead to blood in the stool, et cetera.  So there are some that can be serious. There’s a few that are in between opportunist. Are actually kind of in between a beneficial microbe and a pathogen. So with opportunists, they can be present [00:04:00] in the gut at certain levels. It can be fairly normal to have these opportunistic organisms there. We just don’t wanna see them in excess.  We don’t wanna see them in a certain set of circumstances, especially related to symptoms and diseases where they can actually turn. Into essentially pathogens. So that’s why they’re called opportunistic pathogens typically. Then we have what are called commensals. So commensals is essentially kind of the scientific term for beneficial bacteria or kind of more ge generically bacteria that are just normally found in the gut that usually have neutral to beneficial properties.

Dr. Weitz: Good. So why don’t we start with the bile acid picture. How does bile acid metabolism impact fat digestion, microbiome health, gut motility, inflammation?

Dr. Fabian: So there’s a lot to impact there. So I’ve gotta [00:05:00] start out high level. 

Dr. Weitz:  So we, well maybe start by explaining what a bile acid is.

Dr. Fabian: Okay. So bile acids are basically produced by the liver, so it’s within the category of fats and lipids.  They’re basically formed or produced from cholesterol. So they have kind of, that cholesterol molecule is the basis for the production of bile acids. Their main function, at least in terms of what we recognized for decades since they were discovered is to assist in fat digestion and absorption.  So they’re typically basically transferred from the liver, stored in the gallbladder. And then during a meal when there’s fat content in the meal that basically is detected in the gut sends signals back to the gallbladder to start releasing the bile. So the, basically the bile is released into the small intestine to again, assist with this digestion of fat.

So it’s really a critical component to have [00:06:00] adequate levels of bile. It’s not too high, not too low in the small intestine to assist and really kind of optimize fat digestion. That also includes fat soluble vitamins, like vitamins A, D, and K. You need that bal in order to help us absorb those vitamins as well.

So that’s kind of the traditional view in recent years really in the last two decades. As we’ve learned so much more about the microbiome while these studies have come out, especially in the last five to 10 years, but we now know a lot more about how bal both affects the microbiome in terms of its antimicrobial activity in the small intestine.

But we also know that bile can be acted on by the microbiome in a couple different ways that can influence how bile acids. Then can influence our health. So there’s sort of this whole new category beyond just fat digestion, where bile [00:07:00] acids in their microbiome derivatives can influence in particular intestinal health, particularly the intestinal barrier.

Also immune balance metabolic function. There’s a lot of research, for example, that certain bile acids can potentially stimulate the release of GLP one in the gut. There’s also well known, well established effects on motility. So that’s basically this whole movement of contents through the gut, gastrointestinal, motility.

And then as I mentioned, there’s also influence on the microbiome balance itself.

Dr. Weitz: Okay. So, w why don’t we talk about we, me, we mentioned inflammation in a couple of exchanges we had, and we know that inflammation in the gut is an important factor. It’s found in many. Inflammatory gut condition, especially Crohn’s disease and ulcerative colitis.  And on the GI map we measure fecal calprotectin [00:08:00] and we, there’s another marker, eosinophilic activation protein. So we look for inflammation. And how does bio impact inflammation?

Dr. Fabian: Great question. Yeah, so there’s really kind of two ways you can think of this. And it’s based on the two major types of bile acids that are found in the gut.  So the ones that are released from the liver those are referred to as primary bile acids, meaning that they haven’t yet been acted on or changed by the microbiome. Those are the ones that we know are primarily involved in digestion. In normal physiology, normal healthy physiology. Those bile acids, by and large are.

Reabsorbed at the end of the small intestine in the ileum so they can be reused. Your body doesn’t have to keep remaking them constantly. You can reuse a high percentage of them after each meal through that reabsorption, but unfortunately in some patients, they don’t reabsorb them very [00:09:00] efficiently.

They can have issues in the small intestine that interfere with the reabsorption. Some patients might even have excess production of bile acids, so they’re just not efficiently reabsorbed. So it can be either excess production or just not reabsorbing them in the ileum either way. We can get into some of what’s known about the small intestine and what affects that reabsorption, but once they get into the colon, which normally has a very low percentage of those bile acids in a healthy gut that get into the colon, they’re quickly.

Then converted by the microbiome into what are called secondary bile acids. Secondary bile acids have much different properties, physiological properties compared to the primaries. So basically those secondary bile acids can be anti-inflammatory. They can support a healthy intestinal barrier, but if you’re not converting them very well, and also you’re getting an excess coming in.

Then that’s been shown to [00:10:00] stimulate inflammation. There’s several important studies that just came out in the last year or two demonstrating that basically in various ways, those primary vilas that should not be in the colon in excess when they are, that can stimulate motility. So some patients might actually develop diarrhea that’s referred to as bile acid diarrhea.

They found that actually bile acid diarrhea can be present in IBS patients IBSD diarrhea dominant. Up to 30% of those patients may have this scenario. In IBD inflammatory bowel disease, it’s been shown to be a significant factor now in basically affecting the health of the mucosa. So mucosa are usually damaged to some extent in inflammatory bowel disease.

And then that can also stimulate inflammation. So, there are some, you know, details we can get into as far as sort of what they know about how that happens. But we do know that an excess of those primary bile [00:11:00] acids getting into the colon, along with insufficient secondary bile acids, typically is a contributor to inflammation.

And it’s been documented. So

Dr. Weitz: these primary bile acids, they get secreted into the small intestine where they have an important role in fat digestion. And then they’re supposed to be reabsorbed in the distal ileum, right? And the last part is testing. If they’re not properly absorbed, that’s what we call bile acid malabsorption.  They get into the colon. It’s not a good thing. Exactly.

Dr. Fabian: So what we know from a really interesting study that came out, I’d say probably three, four years ago now out of a group in os Austria they actually found that in a high proportion of IBS patients up to 60% and also in inflammatory bowel disease patients I think it was something like 30 40% had biofilm [00:12:00] build up of biofilm in the ileum.  That was basically the main microbe that was characteristic of the biofilm was an overgrowth of e coli. We know e coli under certain circumstances can be inflammatory.

Dr. Weitz:  It can produce it’s major microbe involved in sibo.

Dr. Fabian: Exactly. So, you know, we know a lot about e coli and then when it’s overgrown in the wrong places it’s not clear exactly why these biofilms develop yet.

They still are studying that. They found that the biofilm was associated with an excess of primary bile acids. So then they found in another study that the excess of primary bile acids then creates an environment in the colon that allows these inflammatory bacteria like e coli to overgrow in the colon as well, particularly in inflammatory bowel disease.

So it seems like these upstream issues that are happening particularly in the small intestine. With biofilm [00:13:00] development in the ileum seems to be related to some of these issues with bile acid, malabsorption, and inflammation.

Dr. Weitz: Now, a lot of people have had their gallbladder removed.  That’s because they get a gallstone or they get gallbladder inflammation or infection and they remove the gallbladder. So without a gallbladder. You don’t have, the body, can’t time the release of bile with that being ingested. So how does that affect this picture?

Dr. Fabian: That’s a good question. So there are a lot of things that can essentially happen as far as complications after surgery like that.

Sometimes there’s some negative effects on that even from the liver when you have the bile coming in not necessarily directly through the gallbladder, but from the liver. There can still be problems with that regulation, but as you mentioned that can be dysregulated. So it’s known from research and we’ve actually [00:14:00] seen some clinical cases already.

Despite the fact this is a fairly new test. We’ve just seen a few of these. But of patients that have had their gallbladder removed, that have persistent symptoms, so they can have a variety of different symptoms, including in some cases ongoing loose stools and diarrhea. For some reason it’s, again, not really clear yet from what’s known in research, but that scenario of removal of the gallbladder and then dysregulation of bile acids seems to be related to the same scenario downstream, where they’re not reabsorbing those bile acids in the ileum de efficiently either.

So there must be some sort of imbalance that causes this dysbiosis, causes this biofilm formation under those circumstances. That can perpetuate these problems for some patients.

Dr. Weitz: Does this indicate another thing we might wanna address when treating a patient with sibo?

Dr. Fabian: I would say [00:15:00] yes. I mean, that seems to be anything that’s happening in the small intestine in terms of overgrowth of opportunists could fall under the umbrella of just generally dysbiosis or sibo.

So if there’s. You know, I would say knowledge from research that suggests what might be going on. It’s a little bit difficult to confirm, and of course we know stool testing is downstream. We can never say for sure, unless the research tells us that a certain organism is only in the small intestine, for example, or only in the stomach like h pylori.

Then we know where it’s coming from even though it’s detected in stool. Some microbes, like e coli, can be small intestine or large intestine or both. We can’t say for sure from a stool test is it really overgrown, but if you’re putting the pieces together and they have bile acid malabsorption, you see an increase on the stool mix in terms of the total bile acids and also the percentage of primary in those scenarios typically.

Then that might suggest that there’s some [00:16:00] upstream issues that you want to further explore in terms of that dysbiosis or sibo.

Dr. Weitz: Now, one of the papers you sent me went into the role of dietary fiber and that how that might play a role in how. Bile acids, increased gut inflammation, and one one of those papers indicated that inulin, which is a common form of fiber, used as a prebiotic.

In fact, many probiotic supplements contain inulin to facilitate the growth of the bacteria. My increased gut inflammation. Can you talk about inulin and what we know about different forms of fiber?

Dr. Fabian: Yeah. Yeah, that’s a really interesting and kind of developing topic. So we know there’s lots of studies showing beneficial effects, especially in terms of short chain fatty acid.

So that’s, you really have to kind of consider, excuse me, the whole gut picture in terms of what [00:17:00] they’re producing, which microbes are there. We certainly wanna also consider the short chain fat. Yes. So they could be compensating. To some extent for some of these issues with bio bile acids. So again, you’re looking at kind of the pros and cons, but this research indicates that inulin under certain circumstances particularly in patients that have inflammatory bowel disease we already know from research and clinical experience that fiber may be a problem for a subset of patients with IBD.

It might make their symptoms worse. So there have been studies to try to figure out why that’s the case and see if we can identify which patients really may be candidates for not not considering inulin fiber, for example. So the studies show that actually what Nulin can do, and of course they’re basically mostly in animal models, so you take it with a grain of.

Although they’re correlating them with what they see in patients in terms of their microbiome, et cetera. But what they found with inulin is that can stimulate [00:18:00] the increase in the bacter bacteria, which are on jmap. So that’s the bact phylum. They are basically capable of metabolizing a wide range of fibers, including inulin.

For reasons that are not fully cleared yet. The inulin seems to especially stimulate those bactes bacteria. They actually produce an enzyme that modifies the bile acids and makes them more damaging in the gut. So that’s what they found in these studies was that the, through the activity of inulin on the bacteria, causing an imbalance, but that then increased the potency of the bile acids.

To cause damage and inflammation in the large intestine.

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Dr. Weitz:  I noticed one of the papers mentioned, or somewhere where they were talking about different forms of fiber. Maybe it was a, maybe it was a webinar on diagnostic solutions lab website.  But they mentioned that whereas inulin in certain cases might cause inflammation, we have partially hydrolyzed gar gum that might decrease inflammation. Do we know why that would be?

Dr. Fabian: Probably because different fibers are acted on by different bacteria, and then they produce a different set of products and they have different effects.  So I’m guessing that with those other fibers, they’re not promoting the tities group that then can make the effects of [00:21:00] primary bile acids worse. So they’re probably. Other microbes that may be their main effect is increasing short chain fatty acids, which actually have an anti-inflammatory effect, particularly butyrate.  So that’s why you really wanna look at the big picture of the microbes, the short chain fatty acids and the vial acids to really put that picture together better.

Dr. Weitz: I noticed the test includes the LCA to DCA ratio. Can you explain the significance of that and how it might affect treatment?

Dr. Fabian: Absolutely, yes.  So it’s basically telling us that there’s an imbalance. So LCA stands for lithocholic acid. That’s one of those major secondary bile acids that are produced by the microbiome. And the DCA is deoxycholic acid. That’s also a major secondary bile acid, also produced by the microbiome. So there are different associations in the research as far as LCA health effects versus DCA [00:22:00] health effects.

So the ratio can, number one, tell us that there’s an imbalance. So even though we might overall have a good level of the secondary bile acids, which is kind of our high level measure of, do things look pretty good? Of when you get into the little bit more granular detail, there can still be imbalances there, and you really wanna have kind of a nice even profile of these secondary bile acids.

As far as, without getting too into the weeds, the imbalance mostly tells us that you wanna look for dysbiosis and try to rebalance the microbiome so you have a more even distribution of products. The con, there’s a little bit of controversy over the health effects. So, LCA, for example, historically has been linked to conditions like colon cancer when it’s in excess.

And I think that still holds up to some extent. It was kind of older research done, you know, a couple decades ago. But now actually to kind of. Flesh out the whole picture. We know that LCA actually for [00:23:00] the most part, unless somebody happens to have, you know, a risk factor for development of colon cancer, it has beneficial effects in many ways.

So it’s, it can be a little bit challenging sometimes to figure out exactly what it means, because there’s research now that shows it promotes a healthy intestinal barrier. LCA has anti-inflammatory activity. And there was a recent study that actually linked LCA to the effects, the positive effects of caloric restriction in aging in an animal model.

So, and there’s lots of links between LCA and LCA related products produced by a diverse microbiome in stimulating the, for example, the GLP one receptor and promoting metabolic health. So it’s really kind of alerting us to. Is there an imbalance? And then what is the presentation of the patient and their risk factors?

Those are always important for [00:24:00] interpretation. Because with a lot of things like hydrogen and sulfide, there’s positive and negative associations, so you want to know what that context is.

Dr. Weitz: It certainly seems like bile is something you want very localized because some patients who have reflux have bile reflux, so if the bile gets too much, bile gets into the colon, that’s a problem.  If it ends up in the esophagus, that’s a problem too.

Dr. Fabian: It is. Yeah. So it’s kind of a, you know, it’s a learning curve in some ways for practitioners who haven’t really necessarily. Focused on assessing bile in their practice. This is giving us a set of information that’s related to what’s happening downstream.  Sometimes it does point to the fact that there may be issues upstream that you want to explore further in terms of liver health, gallbladder, et cetera. So I think it’s another window into giving us some really concrete clues about what’s going on with motility [00:25:00] inflammation, intestinal barrier, et cetera.

More downstream. But again, you wanna look at what are those factors upstream that may be interfering with that process leading to those downstream issues.

Dr. Weitz: Now as functional medicine practitioners, what are some of the strategies we can use if patients have access bile?

Dr. Fabian: Great question. So traditionally, one of the approaches has been to use bile acid binders particularly if patients have bile acid diarrhea.

So I think in gastroenterology that’s still, you know, one of the standard set of tools for consideration in terms of controlling the symptoms. Like

Dr. Weitz: romine on the prescription end.

Dr. Fabian: Exactly.

Dr. Weitz: Yeah.

Dr. Fabian: There’s even some evidence of certain fibers bind to bile acids and may have similar effects in helping to modulate motility.  I think cilium in some cases may do that. I think active HR call, right? So [00:26:00] things that, that basically may help to slow down motility and bind up the bile may be beneficial from a symptom standpoint. So I think there, there’s really gonna be a lot of focus now though on what are these underlying mechanisms causing bile acid malabsorption, such as the biofilm with e coli that I mentioned because of some of the recent studies have shown.

Bile acid binders actually might have a downside that in some patients certainly not all patients, but in patients probably more with the IBD inflammatory bile disease scenario, that it’s bringing in essentially excess bile that’s kind of bound up. But they’ve shown in those studies that somehow that bile still stimulates inflammation.

In some of these patients. So, that may be something just to keep in mind for patients that are not reacting well to bile acid binders or other approaches with fiber, as we just talked about with inulin. Similar effects were shown even with cilium [00:27:00] in terms of the potential, mostly, again, in an IBD scenario, inflammatory bowel disease.

So just some concerns there that practitioners want to be aware of. That even though it might help with symptoms particularly motility in the short term there may be some downsides to consider there and also looking at alternatives.

Dr. Weitz: It’s interesting because we focus a lot on motility in the functional medicine world when we are looking at trying to treat patients with IBS and sibo and generally that condition tends to be more associated with decreased motility, and yet we’re using strategies to increase motility.  So you wonder if. If where bile plays a role in all of this, and you know, patients who are taking pro kinetics, whether they’re prescription or natural it may improve motility, but maybe it increases bile. On the other hand, things that [00:28:00] slow down motility you mentioned GLP one agonist, they slow motility, so they might actually decrease bile, ending up getting into the colon.

Dr. Fabian: So there, there can be some complications there to consider, but overall the research indicates that both for short-chain fatty acids and for bile acids, that usually you’re gonna see, you’re more likely to see a deficiency in both of those because both short-chain fatty acids and bile acids are known probably as far as the microbial metabolites, they’re probably one of the best studied.  As far as their effects on motility and also the mechanisms, right? So understanding the mechanisms is really important. We know both short chain fatty acids and bile acids can interact with receptors in the gut that basically participate in regulating motility. So if you have insufficient levels of both of those.

Or just one category. For some things you might see low bile acids, but normal short [00:29:00] chain fatty acids. If they have constipation, then you may wanna suspect that their lack of bile acids may be a factor in their constipation. So there’s a actually quite a bit of research on bile acids that they can affect motility and essentially promote motility in, in two main ways.

One is acting as a natural prokinetic. That’s one of their main functions. So we’re thinking about, you know, prokinetics are talked about a lot in IBS and placebo field, and we’re usually thinking of supplements, herbals, things like that. Right? We kind of forget that we have these natural factors produced in the gut and modified by the microbiome in a healthy gut.

Of course, that naturally regulate motility, so we would do want to take that into account. And then if of course you have an excess that can cause bile acid malabsorption, bile acid diarrhea.

Dr. Weitz: Now, herbal bitters are often used to enhance digestion, and it’s often said that they stimulate bile [00:30:00] production or bile movement.  First of all, do we, how much do we know that really occurs? Or is that just something we think might occur? And then b might that be some of the benefits? Like I’ve seen herbal bidders in some pro natural, pro motility agents, right?

Dr. Fabian: Yeah. So I’m not, I can’t say that I’m not familiar with the research on herbal prokinetics.  Certainly we know that bitters and other things are pretty well documented to help stimulate the secretory part of digestion. So that’s usually used when there, we suspect that patients may have low pancreatic enzymes, low stomach acid, et cetera. There’s this interaction between secretory activity and also motility.

I don’t, can’t say that it’s all fully understood yet. And that is one of the ways in which bile acids, I mentioned the prokinetic effect, but also bile acids stimulate secretory activity, especially in the colon, [00:31:00] so they can act as a bit of a stool softener. But as far as how the herbals interact, it’s probably somewhat specific to the components that are in each different type of herb.  I’m not really that familiar with exactly how they might stimulate motility in a secretory versus a prokinetic. That both of those can become into play in terms of improving constipation.

Dr. Weitz: Okay, well let’s go into short chain fatty acids and what do short chain fatty acids what important information do they give us and how do they help us to improve our patient’s gut health?

Dr. Fabian: So this one is definitely a bit of a different scenario in terms of interpretation compared to bile acids. So, when we’re talking about production of short chain fatty acids, that’s part of the equation. You want to have good levels, you don’t wanna have insufficient or excessive levels. On stools, we have one of the pieces of information that’s included is the total.  Short chain fatty [00:32:00] acids in absolute terms. So we know basically how much is contained in the stool. What we see in the stool reflects production, which is basically by the, largely by the colon microbiome but also absorption. So that’s unlike bile. Acids are mostly reabsorbed in the ileum. Short chain fatty acids are absorbed actively.  In the colon. So there’s actual transporters in the colon to absorb short chain fatty acids. And that’s how they can have their effects on colon health. For example, we know 70% of the energy of these colon cells, the cells that line the colon, they derive from short chain fatty acids, especially butyrate.

So they need to get across that epithelial lining so they’re continually absorbed. Some of those even continue on. Into the portal circulation that goes to the liver. The liver may metabolize some of those and has metabolic effects where they may sort [00:33:00] of pass them on into systemic circulation, where these short chain fatty acids have effects on the brain, positive effects such as butyrate skin muscle health, et cetera.

So they’re really important for local health in the gut. Also systemic health. But we want to, when we’re interpreting that, we want to consider, it’s not just production. Traditionally in functional medicine, when we see short chain fatty acids on stool test, we’re usually interpreting those in terms of production.

So if we see, oh, butyrate is low, that must mean that butyrate producers are low or they’re just not producing enough butyrate. We also know though, from. Lots of studies that transit time. So in constipation for example, which usually reflects a longer transit time, there’s more time for absorbing those short chain fatty acids.

So you end up with very little in the stool sample. So the two things you want to consider are the production. So you’re looking at the microbes, you’re looking at those [00:34:00] commensals that produce short chain fatty acids, looking at their levels, but you’re also considering the patient’s bowel habits.

Potential transit time. So in constipation, you’re much more likely to see low levels for those patients. So in that case, you know, they might actually have a good level of the short chain fatty acid producers. They might be getting plenty of fiber, so you don’t necessarily need to work on that end of the problem.  You’re working more on the motility side. So if you happen to see the patient also has low bile acids, for example, that could be one of the reasons why motility is low. So you want to focus on. Improving liver, gall bladder health, maybe even considering bile acid supplements.

Dr. Weitz: If we see low levels of short chain fatty acids like butyrate.  What do? What do you think? Obviously it depends on the patient, but what do you think are some of the most effective interventions? Is it better to give prebiotic fibers to feed the [00:35:00] bacteria? Is it better to give specific probiotic strains? Is it better to just give butyrate?

Dr. Fabian: I would say all of the above to consider.  Okay. So studies do show that fiber, for example, can be synergistic with polyphenols in certain probiotics. And we actually summarize that as the, 

Dr. Weitz: and polyphenols a lot of people refer to as postbiotics now,

Dr. Fabian: Poly. So the products the microbiome can produce from some polyphenols like uro, litan a, that uro litan a would be a post biotic because it’s produced by the microbiome from a polyphenol.

So yes, definitely those polyphenols are important for generating some of those postbiotics. And that’s actually one of the four Ps that we talk about. So you have your prebiotics, meaning making sure there’s not just enough fiber, but you wanna make sure there’s the right types of fiber. And Diagnostic Solutions Lab did put out a webinar that’s recorded, so it’s available [00:36:00] through our YouTube channel on our website last fall.

The team put together a great webinar and accompanying resource. As a fiber guide because we always say patients need more fiber when they seem to have a microbiome issue. But the devil’s in the details there as we just talked about. Some patients may not be candidates for inulin at all, for example.

So it’s, it can give you a good guide on what types of fiber may be relevant for constipation, diarrhea, inflammation, et cetera. So there’s a little bit of a learning curve there too, in terms of the fibers. But when it comes to butyrate. So in the context of those four Ps, we have fiber. As far as fiber, we know resistant starch is a well study for helping to promote butyrate production in many people.

I think partially hydrolyzed gure gum also fairly well documented there. There’s one more that I’m forgetting, hopefully that’ll come to me. But so there are definitely specific types of fiber that we know can promote butyrate. And then the second thing would be polyphenols. So we [00:37:00] know that there’s quite a bit of evidence.

Polyphenols can promote not just butyrate producers, but the very bacteria that can help supply those butyrate producers with the precursors they need to make butyrate. So a great example would be bifidobacteria. Bifidobacterium can produce lactate and acetate butyrate. Producers take those other short chain fatty acids and make butyrate.

So again, those prebiotics and the polyphenols can help probiotic bacteria grow that cross feeded the butyrate producers. The third P would be probiotics. So just what we were talking about, lactobacillus, bifidobacterium, and others, even akkermansia. Those can all sort of help promote a healthy ecosystem that supports butyrate producers.

And then there kind, there’s basically butyrate, which is a post biotic. It’s in that category along with Uli a and others. Those are products produced by the microbiome. A growing number of studies shows that [00:38:00] butyrate supplementation has many potential beneficial effects, but especially on helping the entire.

Colon ecosystem potentially to create a better environment for these butyrate producers and other bacteria. And that’s been shown in research to be probably due to the effect that butyrate feeds the colon cells. When the colon cells are fed by butyrate, then the colon cells participate in creating an anaerobic environment in the gut.

Those anaerobes the microbes in the large intestine, the colon are mostly anaerobic. They need an anaerobic environment, meaning lack of oxygen in order to grow. So butyrate actually promotes that anaerobic environment. Right. So I just talked about a lot of information here, so you may have questions or clarification on some of that.

Dr. Weitz: Yeah. I. Yeah, this is a whole new thing. So it’s gonna take a while I think, to really understand [00:39:00] it for most practitioners, including myself. But part of the test reports on branch chain fatty acids. What are the significance of branch chain fatty acids?

Dr. Fabian: Good question. So, we included those because again, there’s a lot of accumulating research now that they help inform us on the state of the colon health, so particularly in relation to the short chains. So you can almost see the short chain fatty acids in the branch chain fatty acids as being antagonistic to each other. So in a healthy gut, we’ve got plenty of fermentable fiber, fermentable carbs of the right kind that can promote short chain fatty acid production.  As you go through the colon, so a lot of that happens in the first part of the colon that fiber fermentation is happening primarily there and into the transverse colon in a typical person. First the microbiome is metabolizing the [00:40:00] fibers that gets depleted eventually, and then towards the end of the colon, microbes start to transition to protein fermentation.

So they’ll basically turn to amino acids for energy when they don’t have enough fiber. And that’s normal to an extent. So you wanna have a little bit of protein fermentation in a healthy gut, but not excessive amounts. Lots of studies show that when you have an excess of these protein fermentation products, that can increase the risk for certain things like it’s been associated with colon cancer, for example.

Some of those products are detected in serum and might be related to poor kidney health, for example. Maybe even issues, gut, brain issues. I think there’s some links, for example, with autism. So you definitely don’t want excessive protein fermentation. The main factor that we know, or I should say factors that increase protein fermentation would be constipation.

So that’s slow motility. You’re exhausting the fiber fermentation kind of early on. [00:41:00] And then because of this smoke slow motility, you’re allowing protein fermentation to happen for a much longer period. Producing more of those products. So you’re more likely to see higher protein fermentation and those various products that are on stools in constipation.

But it can also be due to ex excessive protein intake, which is a concern given the focus on high protein diets for muscle building. As always, in functional medicine, we’re looking at the context of the individual. So you wanna know, is that individual actually handling their protein well? Are they, excuse me, are they digesting and absorbing their protein?

Because if they’re not doing that efficiently, then you’re getting more protein into the colon that can increase this protein fermentation that can have negative effects.

Dr. Weitz: Interesting. So certainly, yeah, I was gonna say, since we do have a lot of focus on [00:42:00] protein intake for building muscle. We also have the popularity among a segment of the functional medicine community that’s using lower carbohydrate diets that are usually higher fat, but also tend to have a little more protein like the ketogenic diet which is being used for brain health, for Alzheimer’s, for all kinds of things.  And and even now the carnivore diet. I’m wondering if. Maybe what we need to think about is for people who want or find those types of dietary approaches helpful, would there be a fiber protein ratio that helps to balance this out?

Dr. Fabian: So research does support that. Now, whether or not there’s sort of a, you know, identifiable ratio I don’t think there’s enough really research yet to say.

A certain amount with a certain [00:43:00] protein. Probably you have to sort of ballpark that and then do some gut testing to see how well you’re doing in that scenario. Again, by looking at your short chains and your branch chain fatty acid production. But there’s a lot of research going back, probably at least a couple decades, showing that adequate fiber intake and adequate polyphenol intake.

Can counteract to a large extent the protein fermentation. So that is probably one of the best well established ways to mitigate the concerns about excess protein. Plus, and this is, I think really interesting research. I’d like to see more research along these lines that we’re always thinking protein for muscle health, muscle building, but it turns out indirectly fiber actually participates in that process.

By promoting these short chain fatty acids that can go into circulation. And as I mentioned earlier, one of the tissues that those short chain fatty acids influence is muscle. [00:44:00] So certain studies recently have shown that these t regulatory cells those are your anti-inflammatory immune cells that are promoted by short chain fatty acids, especially butyrate.

Those can travel from the gut to the muscle. Then help to promote normal regeneration and repair. So say for example you have a hard workout and your muscles are sort of repairing, regenerating after that, building a new muscle indirectly fiber through its effects on the immune balance can affect that process.

Butyrate itself is known to have some effects, positive effects in the muscle. So, you certainly want to think about kind of the bigger picture in terms of overall diet effects. Supporting Muscle health.

Dr. Weitz: This could also be. A negative effect of being on a a lower fiber diet, such as a low [00:45:00] FODMAP diet for a long period of time.  Yes, in the functional medicine world, we often treat patients with a low FODMAP diet. Which we find to be helpful. And then we usually try to broaden the diet and get ’em to have more and more fiber and higher FODMAP foods as tolerated. But there’s a percentage of patients that just find that they can never get back to eating that fiber.  And this is pointing to another potential long-term negative effect of not having a higher fiber diet.

Dr. Fabian: My, my guess based on the research is yes, that there’s likely to be some significant negative effects long term. It’s gonna be somewhat individual. But I suspect that a fair amount of this traces to how individuals actually can handle the carbohydrates and fiber that they’re consuming.  So if you have, for example, various factors contributing to carbohydrate intolerance. [00:46:00] Of course in the short term, you’re likely to feel better when you cut down on those and maybe even switch to a carnivore diet. So from a symptomatic standpoint, we know there’s lots of things that can help with symptoms in the short term, but have long-term negative effects like antibiotics, for example.

Interestingly, there’s research now coming out from a couple different studies showing that fiber, which we think is mostly just active in the colon fiber, actually can also promote small intestinal health. One particular study showed that Klebsiella, which can be one of the bad guys in the small intestine when it’s overgrown is inhibited by fiber even in the small intestine.

They didn’t really work out the mechanism, but this sort of a lot of studies that showed that fiber and the short chain fatty acids that they lead to. Can inhibit the bad guys. These opportunists like Klebsiella e equal citrobacter, proteus, et cetera, that can be particularly overgrown in the small intestine.

So that would be my guess. [00:47:00] And there’s also some evidence that some of these microbes in the small intestine like staphylococcus reus, can actually interfere with the brush border enzymes. And we know deficiency in brush border enzymes with the classic example being lactase leading to lactose intolerance.

When you have a deficiency due to dysbiosis in the small intestine, that might be one of the factors you wanna look at as far as these patients that just seem to not tolerate carbohydrates or fibers very well. So always thinking upstream I think is helpful.

Dr. Weitz: So we need to wrap in the next five minutes or so.  So I’m thinking maybe you could walk us through a case where the stool, all mixed results helped change the clinical approach and then we’ll conclude.

Dr. Fabian: So, because it’s a new test and we do consults on these so far, because it’s only been out for a couple months, I don’t have follow up cases yet.  Okay. That I can speak about. I only [00:48:00] have the primary cases. So the one I had mentioned earlier, we’ve had a few of these examples, whether it’s cholecystectomy, so removal of their gallbladder leading to this increase in the primary bile acids in the colon. And then we see that often associated with inflammatory bacteria.

Recent research shows that there is that connection. Excess primary bile acids in the colon can lead to increase in inflammatory bacteria. So that would suggest, you know, looking at ways to. Reduce some of those inflammatory bacteria using our typical functional medicine tools for dysbiosis, for example.

Even considering biofilm inhibitors, if that seems to be part of the picture. So that’s something that we talked about in the consult is some of these research based insights that might help guide them in which way they want to go. And then. Certainly with inflammatory bowel disease, I’ve probably seen two or three Crohn’s disease cases, similar scenario.

But usually the bile [00:49:00] acid malabsorption was more significant in those cases where the total was quite high and the percent primary was high and the percent secondary was low. And all of those have been linked to potentially worsening scenarios in IBD. Again, that helps the practitioner understand that these are some things they want might wanna look at in terms of supporting and targeting in order to help improve, potentially improve the patient’s situation.

Dr. Weitz: Tom, this has been incredibly informative and I think the stool one makes test looks like a real. Benefit for precision gut health assessment. Where can practitioners go to learn more about it and order the test?

Dr. Fabian: The simplest way is just to go to the diagnostic solutions lab.com website. That’s all just basically one string diagnostic solutions lab.com.  And then you’ll see that there’s the test menu. It’s listed under the GI Maps. If you look at the dropdown menu on our different tests, you’ll see GI Map. And because it’s an add-on stool can’t be ordered alone by itself. It needs to be added on to the GI map. You’ll just see it there and basically when you go to that page, it gives you all the information you need to order the test.

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Dr. Weitz: Okay. And so thank you everybody for joining us and thank you Tom for spreading this information with us. And for those listening, if you find this helpful, please share the episode. Leave us a review on Apple Podcast or Spotify, and we’ll see you next time on the Rational Wellness Podcast.  Thanks so much, Ben. Thanks Tom. Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcasts or Spotify and give us a five star readings and review.  As you may know, I continue to accept a limited number of new patients per month for functional medicine if you would like help. Overcoming a gut or other chronic health condition and want to prevent chronic problems and wanna promote longevity, please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Dr. Austin Perlmutter discusses Brain Health with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

The Critical Link Between Brain Longevity and Lifestyle Choices with Dr. Austin Perlmutter
In this episode of Rational Wellness, Dr. Austin Perlmutter, a board-certified internal medicine physician and Chief Science Officer at Big Bold Health, joins the conversation to discuss brain longevity. Dr. Perlmutter emphasizes the critical importance of brain health and explores connections between neurological health, immune health, and lifestyle choices. He delves into the impact of diet, specifically the benefits of a Mediterranean pattern diet rich in polyphenols and omega-3s, as well as the role of sleep and exercise in maintaining brain health. Dr. Perlmutter also highlights the dangers of air pollution and offers practical tips for everyday lifestyle modifications to preserve and enhance brain function for a longer, healthier life.
00:00 Introduction to Dr. Austin Perlmutter
00:38 The Importance of Brain Health
01:48 Personal Motivation and Family History
03:31 Preventing Alzheimer’s and Brain Decline
05:15 Core Systems Influencing Brain Health
06:15 Lifestyle Choices for Brain Health
08:11 The Role of Immunity in Brain Health
11:45 Gut-Brain Axis and Brain Health
17:21 Nutritional Factors for Brain Health
20:21 Mediterranean Diet and Brain Health
23:26 Ketogenic Diet and Brain Metabolism
30:13 Omega-3s and Polyphenols
35:33 The Role of Diet in Cognitive Health
37:19 Importance of Nutrient Testing
39:05 Choline and TMAO Controversy
42:45 Benefits of Polyphenols
49:15 Exercise and Brain Health
53:03 Air Quality and Brain Health
57:29 Essential Oils and Air Fresheners
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Dr. Austin Perlmutter is is a board certified internal medicine physician, New York Times bestselling author, educator, and consultant. He co-wrote Brainwash with Dr. David Perlmutter and he is the Chief Science Officer at Big Bold Health.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz:  Hello, rational Wellness podcasters. Today I am excited to be having a discussion with Dr. Austin Perlmutter. Dr. Perlmutter is a board certified internal medicine physician, New York Times bestselling author, educator, and consultant. He co-wrote Brainwash with Dr. David Perlmutter and he is the Chief Science Officer at Big Bold Health.  And today we’ll be having a discussion about brain longevity. Dr. Perlmutter, thank you so much for joining us.

Dr. Perlmutter: Thanks for having me.

Dr. Weitz: So, let’s start talking about brain and neurological health and immune health and the connections between all these and longevity.

Dr. Perlmutter: So to start with, the most important thing, I believe the brain health is the only thing that really matters.  And let me contextualize that a little bit. We worry about other problems. So heart disease is certainly the number one killer.  We know that metabolic diseases create all sorts of havoc throughout our bodies.  We know that arthritis, for example, that affects about 54% of people who live to the age of 75 is incredibly debilitating, but why does all of that stuff matter?

It matters because it takes away from your quality of life, the quality of enjoying your life and the ability to enjoy life. To show up each day, to be able to get outta bed and participate in this world and enjoy it for all of its worth is a direct manifestation of what is happening. In that two to three pound organ that we call the brain.

So I realized that if this was the case, then I needed to do a better job of teaching people what to do to keep their brains not only in good health, but in great health across their lifespan. And just for a little bit more background as to why I care about this. So my father is a neurologist. He’s been focused on brain health for his entire life.

His father was a neurosurgeon, was focused on brain health for his [00:02:00] entire life. But in my family, I had two grandfathers with Alzheimer’s disease a disease for which, at least at the time of this recording, there is no meaningful scaled out cure and a disease for which we know we can take amazing steps for prevention.

And that’s just one of the many things that can happen to our brains as we age. So my goal in this conversation is going to be to talk through what we’ve learned about. What causes our brains to age more rapidly and what we can do to help slow the rate of aging and perhaps even reverse certain aspects of that aging process so that we can keep our brains not only basically functional, but working exceptionally well over the course of our lifespan because there really is no value to lifespan without brains span.

I don’t think most people realize this, but there’s not a lot of value to living many years if your brain isn’t coming along with you on the ride in a way that it is healthy. So that’s why brain longevity matters so much, [00:03:00] and I’m excited to get into some of science.

Dr. Weitz: Yeah, I absolutely agree with that.

And I think a lot of people’s worst fears is losing their brain slipping into dementia. And I think that’s one of the reasons why people are so worried about that. And are willing to do whatever it can take to promote better brain health. And certainly when it comes to all these chronic degenerative diseases the treatments for any of ’em are really not that great, and prevention is a much better solution if we can get that started.

Dr. Perlmutter: Yeah, and I’m hopeful that five, 10 years from now, if people listen to this, they’ll say, wow, that was before that amazing cure for Alzheimer’s came out, or before that wonderful new drug came out. I hope that’s the case, but we also need to be truthful about the reality that in 2025, there is no meaningful pharmaceutical way to reverse Alzheimer’s disease or even to slow it too significantly.

So what that means is. For each of us. And Alzheimer’s is just one of the things that we need to be preventing. It’s maybe [00:04:00] the biggest age-related brain decline of any sort of condition, but all of us need to be taking steps right now. If you’re listening to this, if you’re watching this, there is no better time in your life to take steps to protect your brain than today.

I guess yesterday is slightly better, but we don’t really have that opportunity. So today is the day. The steps that we take today can either determine if we are at higher risk for developing Alzheimer’s disease and general brain decline as we age, or at a dramatically lower risk for developing Alzheimer’s disease.

And whether you have an A POE four allele or even two alleles, the reality is that lifestyle modification is the single most important thing we know of that is capable of modulating our risk for developing Alzheimer’s disease. And so this is not just kind of an integrative topic. This is not a functional medicine topic necessarily.

This is just a medicine topic that the best available literature. Is telling us that if our goal is to, and I want to take this one step, it’s not just Alzheimer’s, but if our goal is to [00:05:00] slow the rate of our brain aging so that we can protect our brains over our lifespan so that they are partners with us and not just us kind of being carried along to whatever our brains decide they’re going to be doing.

And they, the years after age 50 or so. These are amazing steps that we can take. What’s super interesting for me and for the research that I’ve been doing is the understanding that there are core systems that modulate the speed with which our brains age. And these systems just to go over a couple are able to influence to a significant degree our overall brain health right now and in years to come.

And the ones that I’ve been most focused on are metabolism. So our brain’s, metabolic health immunity, our brain’s immune health, and then neuroplasticity, which is a technical term for the fact that our brains are perpetually rewiring themselves. And the relative ease and value of those connections has a significant role to play.

In our overall brain health. So these are kind of the neurobiological systems that undergird things like [00:06:00] mental health and cognitive health and importantly, we are able to influence those systems, whether they’re going to be kind of bias towards brain health or bias towards brain disease through the decisions that we make each day, and specifically through our lifestyle choices.

Dr. Weitz: So what are some of the biggest levers we can push when it comes to making these lifestyle choices? I know I’ve heard you speak talking about the fact that one of the biggest things we can do is make sure we optimize our sleep.

Dr. Perlmutter: Yeah. Well, there are many things we can do, and maybe before we get into some of the specific levers, I just wanna make a general disclaimer here because I think that it’s important for people to understand that in this era of sensationalism, the best data that we have for the things that are going to significantly.

Decrease the rate at which our brains age and significantly increase our chances of having a healthy brain into our later years. Our basic lifestyle modification, it’s not extreme diets, it’s not extreme supplements, it’s not extreme biotech [00:07:00] companies that are gonna give you some sort of a device that solves everything.

It’s doing the basics well. That is, again, 2025, the single best data point that we have. So. There’s definitely some value in doing the extreme stuff, but the majority of the value that people will get in terms of protecting their brains is going to be basic stuff. For example, traumatic brain injury is a major preventable driver of brain dysfunction.

Not just mental health issues, but the development of dementia and overall worse brain health. So what can we do to prevent TBI? These are simple things. Wearing a helmet, if you’re on a bicycle, wearing a seatbelt, if you’re in a car being cautious, if you’re an elderly person to take steps to reduce your risk of having a fall.

And I don’t mean this as something that, you know. People are gonna get excited about. This isn’t some sort of an amazing hack, but what I am trying to say is these are the types of steps that the science is clear on. That we can take small steps each day to mitigate in a major way our [00:08:00] risk for developing brain health issues down the line.

Now there are some really exciting aspects of what the science is telling us we can do to act upon these key pathways. And as I’ve alluded to. One of the key pathways that is absolutely vital in determining our brain health right now and in the future is immunity. So, you know, I learned in medical school that the brain is made up of a whole bunch of different cells, but we primarily focused on cells called neurons.

That’s the brain cell that most people are aware of, and it’s a great cell. Don’t get me wrong, you have 80 billion or so neurons in your brain, but there are roughly 80 billion or so other cells called glial cells, which comes from the word for glue. Because initially it was just thought these cells served to hold things together.

It turns out that glial cells play a massive role in mental health and cognitive health and decision making. Even in personality, and one of the most important of the glial cells is a cell called the microglial cell. Microglial cell. Somewhere between 10 [00:09:00] to 15% of all the cells in your brain, something like 20 billion cells in your brain.

What makes it so interesting is that it is an immune cell that lives inside of your brain that changes its function, that changes its physical shape depending on the data that it receives, and based on the way that the microglial cell changes its form and function, it actually influences the way that your neurons work.

So what we’re saying here is your brain has an immune system. It has these microglial cells. These microglial cells are listening to what you do each day, whether you exercise, if you eat a healthy meal, if you had good sleep, if you’re breathing in air pollution, what is the quality of the things that you’re consuming?

And based on that input, they dramatically transform their function. And this has now been determined to be a principle driver of everything from the rate of brain aging to depression to PTSD, as well as to risk for developing dementia and specifically [00:10:00] Alzheimer’s disease. So this brings this concept of immunity, which is generally something people think about, is happening only as a defense system.

You know, you get a cold, you get a flu, you need your immune system to rev up, you wanna make sure you’re topped off on vitamin C. So your immune system works well. Actually, that is such a small part of what the immune system does because the immune system is a principle force translating the outside world into the inside world.

And because your brain, as amazing as it is, doesn’t really have access to the outside world, it relies on signals in part through the immune system. To know how to change itself in order to guide us towards ideally survival, not necessarily thriving, but survival. So immune system in the brain, significantly directing how we think, how we act, how we feel, and being directed by our lifestyle choices, what we consume each day.

Programs, the brain’s immune system. And by doing so, programs, our brain health.

Dr. Weitz: And this is a [00:11:00] new concept because we used to think that there was this impermeable blood brain barrier. So there were no pathogens in the brain, there were no toxins in the brain, and there was no need for it to have a brain immune system.

But we’ve learned that’s not really true.

Dr. Perlmutter: That’s absolutely right, and I think this is still a common misconception. You know, it, it kind of stems from another really popular misconception, which is that the brain and the body don’t communicate that you have what happens in the brain and you have what happens in the body.

And you know, maybe they occasionally exchange a letter, but by and large they’re not talking. And what we now know is. That there is constant bidirectional communication between the brain and the body. And the best example may just be this gut brain axis. And we know that what happens in our GI tract, especially our microbiome, but also in our gut immune system, is able to influence what happens in the brain through a variety of different channels, the vagus nerve, the bloodstream.

And so we’ve kind of gotten [00:12:00] rid of, at least in the scientific world, this idea that the brain and the body. Exist in isolated chambers, but I think most people kind of fail to understand the gravity of that science because what it says is that your brain doesn’t exist away from your body. That your decisions that you make in terms of the food that you eat, in terms of even what you put on your skin, what you breathe, how they direct influence on your brain health.

And I mean, I can give so many examples of how this happens, but maybe the one people are most familiar with is hunger. So what is hunger? Hunger is a response to sure a low energy state, but it’s programmed by hormones that are produced, for example, in your stomach, one called ghrelin, that actually increases your level.

Of hunger. Another called leptin that’s produced in part in the gut, but also in your fat cells that helps you to feel full. It’s a satiety hormone. So what that means is signals from your gut, signals from your body, signals [00:13:00] from your fat cells are telling your brain how to behave and telling you how to change your decision making.

So if you follow this line of reasoning to its natural extension, what I’m saying here is even though we like to operate as though. We’re in control. We’re up here. We’re directing all of the things around us that our brains are responsive in real time to the things that we are consuming to our environment.

And this is one of the reasons why I would say that your best opportunity for making healthy decisions and having a healthy life is not to rely on willpower and forcing yourself to make healthier choices, but it is to program your brain to make it more likely that you make those healthy choices to make it easier.

This is kind of the whole idea of developing healthier habits. Your brain, as much as we see it, as part of us as our identity is constantly changing, and we have the opportunity to rewire our brains for health. Or let our brains be rewired by what happens [00:14:00] around us, which by and large, when you look at the consumed data points in the American world and largely around the world, what we’re consuming is programming our brains for disease and poor health.

So it is incredible opportunity for us to change the narrative and build brains that not only serve us today, but for decades to come.

Dr. Weitz: So how do we reprogram our brains that way? You’re talking about having a eating schedule, an exercise schedule, a sleep schedule. Is that what we’re talking about?

Dr. Perlmutter: Sure.

There are many things you can do, any person can do to help bring their brains back to a state of relative balance. I do think it’s important for everyone out there to know. That your brain changes every day, every moment across your lifespan. So it isn’t as though you’ve missed your opportunity If you’re 70 and saying, oh, I’m not thinking as clearly as I used to.

You always have the ability to direct your brain function for the better. And one quick point that I wanna make before we jump into some of the [00:15:00] tangibles here is that some recent research came out and it in essence showed that midlife so kind of. The middle period of our lives is a key window in terms of what directs our rate of brain aging.

There’s a publication called The Middle Aging Brain that came out in trends in neurosciences, and what they said is that between the age of 40 and 65, this is a key window that directs your future for brain health, and the key pathway seems to be the immune system. So let’s talk here specifically about what you can do to help program your brain’s immune system towards a better state, a state of relative balance towards a state that helps to hopefully prevent your risk of developing a host of brain related disorders, because as I’ve said, it isn’t just your risk for developing dementia that’s associated with a brain immune state activation.

It’s also very strongly a risk factor for depression, which is one of the reasons why I wrote a paper back in 2021 looking [00:16:00] at COVID and the pandemic and the correlations between infection with COVID, but also. People’s lifestyles as a function of lockdown. So this was kind of an interesting thing because back then, as of now, as now, there’s a lot of polarization around what happened, what went wrong, what should we or shouldn’t we have done?

And the point that I made was whether you’re worried about a virus or worried about the lockdown procedures, depression was rampant. And it’s because in part, we’re programming our brain’s immune system towards inflammation. So our goal here is to try to go against that chronic neuroinflammation brain inflammation in order to preserve brain function, enhanced brain function, and protect against what happens in the future.

What can we do about it? I would say. You want to be thinking about the ideas of what you’re consuming each day. So what we consume becomes our biology, and that’s across the entire spectrum. So for example, if you were to be [00:17:00] exposed to a bunch of radiation changes our biology, but more practically for most people, you want to think about what you’re breathing.

You want to think about what you’re eating, you want to think about what you’re putting on your skin. And if you cover those bases, you’re actually getting the majority of the major lifestyle variables. I’d say exercise and sleep slightly outside of that, but we can talk about that in a second. So when we think about the nutritional or yes, let’s start with nutritional.

When we think about the nutritional variables that are most associated with inflammation in the body and in the brain, what I would say is on the one hand, you have the things that you don’t want to consume because at high levels especially, they’re correlated with higher levels of inflammation.

There’s two major things that I would like to address there. One is the Western pattern diet, the standard American diet, the ultra process diet. We can talk all sorts of nuance around individual nutrients and keto and paleo, but the bottom line is if you consume ultra processed food, [00:18:00] most of the time you’re putting your brain and body at risk of chronic inflammation.

So what is an ultra processed food? There are different scales that you can use to determine whether it’s ultra process or not, but one really easy way to determine if it’s an ultra processed food is if you read the ingredient list on the back of a food, and there are things there that you don’t have in your kitchen that is most likely an ultra processed food.

Now, are all ultra processed foods equally concerning for brain health? No. There’s one in particular that I would say is at the top of the list that I would highly recommend most people. I would say everyone should dramatically cut back on or try to avoid completely. And that is an ultra processed food that has almost zero value in terms of what it provides for health.

And almost everything slated towards what it takes away from your health. And that is sugary beverages, sugar sweetened beverages. There is no nutritional value in these beverages, aside from the calories that come from the sugar. So if you were absolutely [00:19:00] starving or if you were incredibly dehydrated, sure.

But for most people, and most of the time, they’re getting absolutely no value from consuming sugary beverages. And sugary beverage consumption is correlated with worse brain health, higher risk for dementia, higher risk for depression. And why is this the case? Well, all that sugar appears to rev up the immune system and promote neuroinflammation.

So very briefly, ultra processed foods eat less of them, but specifically try to avoid the sugar sweetened beverages. And as long as we’re on the topic of beverages, I think it’s notable that. Large doses of alcohol seem to activate microglial cells, increase brain inflammation, so there’s still a lot of debate as to moderate, mild high levels of alcohol, but at high levels and specifically in alcoholism and other people who have had specific brain damage related to alcohol, one of the key mechanisms appears to be neuroinflammation.

So if you’re worried about brain inflammation, high levels of alcohol. [00:20:00] Not a good idea. So those are kind of from a nutritional perspective, the things that I would recommend against in order to decrease your exposure to neuroinflammation and all the things that come with it. On the flip side, if we’re talking about what to do more of, well the opposite of an ultra processed diet is a minimally processed diet.

It’s foods that humans have messed with the least. And what’s kind of nice about brain research is there’s conclusive data, at least as of now, 2025, that there is one diet that is kind of the best overall diet for most people to prevent brain issues and to in particular, help to slow brain aging by targeting these key pathways.

And that’s the Mediterranean pattern Diet. Many people have heard of it before. Different people have different ways of kind of describing the Mediterranean pattern diet, but the key to it is made up of a lot of minimally processed foods. You have fruits, you have vegetables, olive oil, nuts and seeds.

It tends to deprioritize red meat. [00:21:00] It tends to have you consume more fish Omega-3 rich foods. And in particular it is a diet rich in molecules called polyphenols, which are these plant-based nutrients that have been associated with better brain health. So a minimally processed Mediterranean pattern diet is the diet that is best studied to help slow rated brain aging, prevent dementia, and even to improve neurological function in the context of things like.

Depression and mental health issues. We can get into a lot of the specifics of it, but kind of the core constituents that I’ve been most involved in studying, again, polyphenols, Omega-3 fatty acids. These are nutrients, polyunsaturated fat, linked to better brain health, and then fiber, which is something that most people just are not consuming even half of what they need each day.

So I’ll pause there. That’s a lot specifically on the nutrients that can help to offset some aspects of the brain aging process. The good news to all of this is even though there’s no magic bullet, that every [00:22:00] day there’s a chance to do slightly better when it comes to the food that we’re eating.

Dr. Weitz: Right. And it turns out that the Mediterranean diet, even though it’s always a little bay, does it include dairy? Does it include bread? Does it include this? But we have a general sense of what it is. It’s also seems to be the most effective diet for reducing cardiovascular disease and most of the other chronic diseases.

So I think that all sort of goes hand in hand.

Dr. Perlmutter: Yeah, there, there’s no huge liability here. I mean, I think for certain people, you know, there’s a lot more to be said about maybe saturated fat intake and the forms of fat intake. But by and large, what’s great about the Mediterranean diet is that population-based analysis and even interventional data support, that it is a good diet for basically every condition.

So it is a general longevity promoting diet and it also happens to be good for brain health. So it’s nice that you don’t have to say, well, actually this diet is the worst diet for your heart, [00:23:00] but it’s really good for your brain. You don’t have to choose, in this case, which always makes it a little bit easier to be talking about,

Dr. Weitz: you think that somebody who’s starting to have the beginnings of symptoms of decreased brain health.

Should consider more of a ketogenic yeah. Focused diet where maybe they’re gonna be getting their energy more from fats and from carbohydrates.

Dr. Perlmutter: It’s, so there’s an interesting correlate here, which is this question of brain metabolic function and something called cerebral hypometabolism, which is a complicated way of saying as the brain gets older, it seems to have more trouble extracting glucose and using glucose this doesn’t mean there’s less glucose around.

It just seems like the brain metabolizes glucose worse. And this change in metabolism, which some people call type three diabetes is correlated with. Overall brain atrophy and risk for mild cognitive impairment and risk [00:24:00] for Alzheimer’s disease. So what you’re bringing up here is mechanistically. It seems that as we age, our brains become less able to use glucose as a fuel.

I should say this. Glucose is the brain’s primary fuel source. We mostly run on glucose. So this isn’t saying sugar is bad, we need the sugar to run on a brain. So that’s very different from saying added sugar is good, added sugar not good, but we do need to have stable levels of glucose. So a diet that is low in carbohydrate, or I should say just fasting not eating anything whatsoever.

Would increase levels of what are called ketone bodies. And what makes these ketone bodies interesting is that they actually are a more I shouldn’t say bioavailable, but the brain actually will use those in place of glucose. And so that’s interesting. It’s not just the brain, the heart, other tissues can use ketone bodies.

And so the hypothesis here is that if a brain has more trouble using glucose for a number of [00:25:00] reasons, you could bypass that fuel source and provide ketone bodies either through a diet that is very low in carbohydrate, or through fasting or through exogenous ketones. So you can now consume ketones in little, you know, shots or beverages.

What we know so far is that mechanistically, it should work. There have not been any large scale studies proving that a ketogenic diet is, powerful in terms of reversing aspects of Alzheimer’s disease or even significantly mitigating the cognitive issues. There’s some data for improvement in symptomatology, so kind of activities of daily living.

I’m optimistic that metabolic therapies will actually prove to be efficacious for Alzheimer’s disease, and I’m not in any way opposed to ketogenic diets for people who have metabolic dysfunction because not only may it be beneficial for the brain, but cutting back on carbs I think can actually be quite advantageous, specifically in reversing aspects of type two [00:26:00] diabetes.

And so there’s some really powerful data showing that you can reverse type two diabetes with a low carbohydrate diet. My concern around this would be if you are a person who is looking at decades of of age ahead of you, and you’re trying to do the best you can to protect yourself against Alzheimer’s and other brain related issues.

And you start a very restrictive diet like the ketogenic diet. Not only could it put your body under metabolic stress long term, and that’s some of the data that we’ve actually seen in fasting and other more restrictive diets, but you’re missing out often on things like fiber and polyphenols that have also been correlated with better brain function.

So I think I would be opposed to a wide scale recommendation that people should adopt a ketogenic diet for long periods of time for brain health, because I don’t think the data substantiates it. I would be in favor of trying a ketogenic diet. If a person has underlying metabolic dysfunction, which to be fair is about 90% of Americans, but in the context of doing it [00:27:00] alongside a practitioner where you’re actually monitoring and creating a plan for.

What is the sustainable version of this look like? Because I don’t think, just like I wouldn’t recommend long-term fasting for people, I don’t think it is reasonable to bypass the whole question of, is this sustainable when we make dietary recommendations? So I’m interested in the ketogenic diet. I’ve been following the literature.

There’s some preliminary data suggesting some potential value, but as of now, I think it’s still too early to make a broad recommendation specifically for brain health that a ketogenic diet outweighs something like a Mediterranean pattern diet.

Dr. Weitz: And when we talk about metabolic health for brain health, I recently read Chris Palmer’s book, brain Energy, and he talks about the importance of brain getting enough energy through the mitochondria.

And so therefore, what we’re using for energy, whether it be carbohydrates or fats or a combination thereof, is very important for overall brain health.

Dr. Perlmutter: That’s [00:28:00] right. I mean, the brain, two to three pounds uses up 20 to 30% of your glucose at rest uses up a ton of energy. And so if for example, you were to cut off blood supply to the brain and you didn’t have access to glucose and oxygen, you’d die within minutes.

Right? This is not kind of a a long-term process that the brain is able to work without energy. It has tons of mitochondria. You have thousands of mitochondria, potentially more per neuron. They’re clustered around areas that require lots of energy specifically to reset after depolarization. And what does seem to be pretty strong data is that as our systemic metabolism is compromised, and again, depending on the study you look at, it’s somewhere between 88 and 92% of Americans now with some aspect of metabolic or cardiometabolic dysfunction.

But as our body becomes resistant to insulin, as our blood sugar levels start to go up, as we start to develop dyslipidemia the other things that accompany metabolic syndrome. And a fat [00:29:00] that is more programmed towards inflammation. Our brains are not immune to this. And so while there may be a kind of a slight buffer in between developing systemic metabolic dysfunction and brain metabolic dysfunction, there’s no clear line to say, okay, your body’s metabolically unhealthy, and your brain is fine.

It doesn’t seem like that’s the case. So there’s a lot to be said for, you know, the pathways involved, what we can do around that. I do think you know, Dr. Palmer and others have really called excellent attention to the fact that your brain’s energy function is critical for. For general health, but also to mental health.

And I think that’s something we’re learning. I wouldn’t say the data is nearly as strong for metabolism and depression as it is for inflammation and depression, but we’re starting to get more and more of an understanding as to how these pathways interface. So certainly metabolic function, something we all need to pay attention to.

I just think as it stands right now, it’s a little bit more towards immune [00:30:00] activation for the mental health, cognitive health continuum and the metabolic health is a little bit more towards long-term cognition in terms of the risk profile.

Dr. Weitz: What are some of the other important dietary factors? You mentioned Omega-3 fats, which we get from eating fatty fish taking fish oil supplements, and potentially also some alpha linoleic acid that we can get from nuts and seeds.

Dr. Perlmutter: Yeah, so, so I think you know, at Big Bold Health we’re focused on three pillars of kind of nutrition. So one is the omega threes, as you’ve mentioned. Omega threes are interesting in that they’re highly kind of conserved and prioritized in our brains. So our brains are mostly fat by weight, but they’re also incredibly rich in one specific Omega-3 called DHA or docosahexaenoic acid.

And so we want to make sure our brains get enough of that to be able to maintain membrane fluidity, to be able to maintain general immune balance with more EPA or [00:31:00] cosent acid. So the or sorry, cagno acid. So the the basic idea here would be that we want to make sure that we’re prioritizing omega threes.

And by and large, most people don’t consume enough omega threes. I don’t think that’s highly debated. You can get it from diet, so it’d be great if you’re able to get access to, ah. Salmon seafood, eat that each day. The reality for most people is that’s not sustainable. So then you get to kind of supplementation.

I think many people are kind of fixated on this idea of getting two to three grams of EPA plus DHAA day. I’d say most of the quality recommendations from various groups would say closer to 500 milligrams is kind of the sweet spot for maintenance. Now, there are certain conditions, for example, depression where about two grams of, again, EPA predominantly, but also DHA seems to be most effective.

But most of us benefit from just shooting for that 500 milligrams a day. Again, D-H-A-E-P-A, there’s some data for [00:32:00] alpha-linolenic acid, as you said, a LA, this precursor to EPA and DHA. But what seems to be key to understand is that most people cannot convert the a LA to the EPA and subsequently the DHA at high enough levels to where they’re actually getting access to that.

If they’re only consuming plant-based sources. So if you’re a vegan, if you’re somebody who primarily eats plant-based food and you’re not consuming any seafood, I think you’re probably going to wanna look at supplementing with something like an algae-based Omega-3 supplement. Beyond the omegas. The real kind of concentration of my research with big, bold health has been on polyphenols.

And so polyphenols are a group of molecules, 8,000 plus molecules found in plants that have been historically thought about as kind of throwaway molecules, meaning they don’t do that much. We’re now understanding that they’re actually one of the key sets of nutrients that signal between the soil and the plant and the human meaning.

That polyphenols change the microbiome of [00:33:00] the soil, that plants actually send out polyphenols to attract various microbes. And they communicate in this way to promote a healthier plant that polyphenols then can translate those polyphenols to us when we consume them. And that when we eat polyphenols, they have names like quercetin and rootin, that these molecules can have effects on our microbiome, our immune system, and by extension may influence our brains.

Some of these may actually penetrate the blood brain barrier and influence brain immunity. And so we’ve been focused on polyphenols from a certain plant called Himalayan Tery buckwheat, which is an interesting plant because unlike most things that people tend to consume, it’s incredibly high in polyphenols.

And so, if you think about, you know what people typically eat in a grain-based form, wheat rice, these tend to be. Basically stripped of the hu, which is the most strong source of polyphenols. So they’re low in polyphenols. They basically convert to sugar quickly. They’re low in fiber. Buckwheat [00:34:00] has higher levels of polyphenols, but there’s a variant of buckwheat called tart buckwheat that is a little bit bitter.

And the reason for that is because it’s so concentrated in these polyphenols, in particular rootin. I think it is the single most concentrated form of rootin, of any plant that exists. And so we’ve been looking at this subset of polyphenols as to how it relates to immunity. And we studied this in a trial that we published last year in Frontiers and Nutrition, showing that the polyphenol compliment in this Himalayan artery, Bucky.

Significantly impact metabolic, immune and longevity related pathways, which from my understanding at least at this point, is pretty much the first study to ever look at tery, buckwheat and show that it can impact these immune and longevity pathways. So polyphenols, I think, really important to consider I for overall health, for longevity, and we’re starting to look at this more as it relates to brain function.

Other nutrients to consider here. I mean, there are many, so magnesium something that a substantial percentage [00:35:00] of Americans are really not consuming enough magnesium. There’s a debate over the right form of magnesium that has the most kind of brain availability. But the bottom line is you want to be getting several hundred grams or a hundred milligrams of magnesium each day to support good brain function.

And there is data showing that when people do not consume adequate magnesium, that their brain function declines. Similarly, there’s data now for creatine monohydrate, specifically at around the five to 10 gram a day range in terms of supporting overall brain health and promoting brain energy, which I think is super cool.

There’s data around vitamin B, there’s data around vitamin D, but I think the cornerstone to this is really diet. It’s not the supplementation. So trying to build a diet, again, the Mediterranean diet. Which is high in all these things, naturally is a great place to start. And I think that if you’re concerned about this, especially if you’re concerned about cognitive decline, you know that’s where a healthcare practitioner is really best situated to help you because it’s [00:36:00] not as helpful to just assume that you should take vitamin D.

Some people may have a very low vitamin D despite thinking that they’re high, and other people may not need supplementation. I will tell you from getting my own levels tested, I never know exactly what I’m gonna get back until I’ve seen those labs, and then you can change your levels of intake. Maybe you just need 5,000 IUs.

Maybe you need a whole lot more. Maybe you need a whole lot less, but you won’t know unless you actually test. So bottom line to this, lots of nutrients that influence the brain. I think Omegas, polyphenols, creatine, magnesium, those are some of the top ones on my list and things that I try to prioritize each day.

I think the creatine is one that you really can’t get enough from diet for most people because we’re talking about five to 10 grams magnesium. Some people get enough through diet Omegas, maybe some do, but probably not. And then polyphenols, you gotta be prioritizing a lot of plant-based foods, a lot of spices, a lot of herbs.

And if you’re not doing it through that mode, you may not be getting kind of the one to two grams of [00:37:00] polyphenols a day that are probably best situated to be supporting overall health.

Dr. Weitz: Yeah. Definitely inflammation is a big factor and omega threes help to reduce inflammation And I even like using the, the the resolve ins from fish oil to help reduce inflammation. When it comes to testing, I think that’s super important. There’s no way you know how much you need of various new. Nutrients unless you test. There’s so many different factors. You don’t really know what the content of food is.

You can look at a chart and see that eating a carrot has this much vitamin A, but each particular carrot has a huge variance. We have different receptors, we have different metabolisms, we have different abilities to absorb nutrients. So if you don’t test, you’re guessing. And so I think it’s super important that all of us get our important nutrients tested.

You mentioned vitamin D and Omega-3 [00:38:00] and magnesium, but I think if you can get all these nutrients tested and do that periodically, I think that’s the best, most scientific way to know you’re getting optimal levels. That’s what we need. We want to get optimal levels of all these nutrients and not just what’s considered the normal level.

Dr. Perlmutter: Yeah I totally agree with you and I think you know, I think sometimes people say, oh, I’m just going to tweak my diet a little bit and should be fine. And that’s the great thing about labs because unless you know, the lab company messes up, which does happen on occasion, you’re actually getting a good snapshot as to what is happening in your physiology.

And I think there’s a risk to over supplementing just as there’s a risk to not getting any additional nutrition if you need it. So I think that is a good call. I will just mention a couple of other nutrients. Choline lutein, xanthin. These are all nutrients that have been studied to potentially help with certain brain aging pathways, including inflammation.

And so, you know, these are things that you can take in supplement form. Egg yolks tend to be very rich in [00:39:00] them. Leafy greens. I feel like I’d be remiss if I didn’t mention it’s a great source of a lot of these nutrients that we’ve been talking about. Can

Dr. Weitz: we talk about choline for a second? Yeah, go for it.

So choline a, there’s a bit of controversy about it because for sure there’s tm, there’s a particular Yeah, exactly. TMAO. So we have this researcher from Cleveland Clinic, Stanley Hazen, who’s done some research showing that TMAO levels increase your risk of heart disease and consuming choline, a carnitine increases your risk of TMAO.

In fact, FISH is the greatest natural source of TMAO directly. And yet we know these foods like choline and fish are so beneficial for our overall health, for brain health, for cardiovascular health. So I have a tough time with that TMAO concept.

Dr. Perlmutter: It’s interesting, right? So the TMAO is one of the most consistent kind of data points that vegans or plant-based people will point to in terms of saying that, you know, eggs are [00:40:00] bad, seafood’s bad generally speaking based products are bad.

You know,

Dr. Weitz: unfortunately in this set of diet wars we have people lining up in different political parties and sometimes they’re looking for, you know, a weapon that they can use and there’s the TMAO weapon to show why the vegan diet’s best.

Dr. Perlmutter: Yeah. So, I’ll just say, and as somebody who, you know, doesn’t have a huge bone to pick in this, other than I think it’s really unhelpful when we keep going back and forth on what people should be eating.

So, TMAO has actually been linked to this is trim triethylamine an oxide, right? Trimethylamine an oxide, which is a metabolic byproduct of choline. So. Is linked to specifically cardiovascular disease specifically atherosclerosis and death from cardiovascular disease. So the idea then is if you eat a bunch of choline, you make a bunch of TMAO and therefore higher risk of cardiovascular [00:41:00] disease.

But then the question is that the actual pathway? Or is it measuring something else? And so my understanding of the data right now, and I’m sure that you’ll have guests on, or maybe you know this better than I do, is that there is no direct study showing that choline intake correlates with worse cardiovascular outcomes.

There’s this surrogate where there’s an assumption, which is because choline increases, TMAO and TMAO is linked to higher levels of cardiovascular disease. Therefore choline is bad. But in terms of what I can tell right now, there may be a confounder or another variable, but I’m not seeing the data showing that specifically.

Consumption of choline translates into worse cardiovascular disease. And you would think if that was the case too, just as you said then higher consumption of things that are rich in choline would correlate with higher levels of cardiovascular disease. But that’s not really what the research is telling us, so, right.

I think, yeah,

Dr. Weitz: I think that, I think the key factor is the microbiome. And I think that people who produce [00:42:00] TMAO, it’s not because they’re consuming choline, it’s because they have a a dysfunctional or less than optimal microbiome. And I think if they change their microbiome, they won’t have a problem with TM ao.

Dr. Perlmutter: Yeah, I think it’s certainly an interesting thing. I mean, there’s a lot of mechanisms at play to talk through, but we know choline is an essential nutrient for brain health. And so personally, I have not modified my diet based on the TMAO component in terms of decreasing choline intake.

And I think I would be super interested to keep following this research, but I think this may be a scenario where you know it’s part of the story but not the complete story. So. Right. A little tangent there on Colline, but certainly Interesting.

Dr. Weitz: Yeah. So polyphenols, these are part of the phytonutrients that we find in plant foods.

And we know the importance of all these different phytonutrients, including polyphenols. And the way we can get [00:43:00] ’em is by eating lots of colorful plants, fruits and vegetables and and then there specific seeds and grains like the Himalayan Tart buckwheat.

Dr. Perlmutter: Yeah, that’s right. So the richest source of polyphenols in the diet is going to be, I think, as lasso, right?

I think it’s cloves of all things, but it’s spices and herbs are gonna be the most concentrated source of polyphenols. But any minimally processed plant food is going to be a good source of polyphenols. The more food has been processed, typically the more the polyphenols are removed. So again, going back to the example I gave before, if you’re eating a bleach white flour, if you’re eating a bleach white piece of rice, that’s gonna be.

Probably much lower in polyphenols than eating a colorful piece of fruit. And what’s interesting about polyphenols is that they have this they can actually create some bitterness when you eat certain foods. That’s why coffee is bitter. It’s why dark chocolate is bitter. And so we can offset that by adding sugar, which is what most people do, or fat, [00:44:00] which is a popular thing.

So there’s a reason why the top form of chocolate is milk chocolate and why most people like a latte and don’t drink, you know, a black coffee first thing in the morning. And usually add sugar to both of those things as well. But the fundamental kind of idea behind this is that. When we consume bitter foods, we’re actually programming our immune system through these polyphenols.

So bitter isn’t bad. Bitter is actually a signal that we’re getting good levels of these nutrients. And so that’s what we found with tartar buckwheat compared to even conventional buckwheat, it is a little bit more bitter, and that’s because of the polyphenols, but what we’ve been doing is sprouting it.

And what’s interesting about the sprouting is that you actually produce a new molecule, a new polyphenol that helps to dampen down the bitterness. So it’s kind of a polyphenol metabolite that has an anti bittering effect. It’s homo aol of all names, right? It’s a kind of a random one, but this is a nutrient that helps to decrease bitterness to the point where companies will actually put this in their foods as a way of [00:45:00] offsetting bitterness.

And what happens with this tar bucket is when you sprout it, you produce an anti bittering agent, which is just a cool little bit of biology. As we’re looking at what poly what polyphenols do to our physiology, what is known is that polyphenols are actually a form of prebiotic. So they influence the microbiome, they change the makeup of the microbes in our gut.

Polyphenols also appear to influence the immune system, both indirectly, for example, by influencing the microbiome. And they seem to bind to immune cells and change their programming. And so, polyphenols are now thought to be kind of messengers that alter. Immuno metabolic pathways. And so this is just kind of taking this story and making it more and more complicated.

But metabolic health and immune health are not separate, right? So our immune cells are powered by metabolism, and our metabolism is influenced by our immune system. And so polyphenols act on both sides of that pathway. So polyphenols. Are thought to [00:46:00] be immuno metabolic agents that can actually change our risk for chronic diseases and impart influence brain health.

So it’s kind of just a really cool area of science because we’re taking this idea of food is medicine and we’re expanding it beyond just the idea of, oh, well, polyphenols are antioxidants. Antioxidants are good because oxidative stress is bad. And now transitioning to saying, actually no, polyphenols are changing the signals within our body, influencing our immune system, influencing our metabolism, and this may be one of the reasons why people who live in these blue zones that Dan Butner has described tend to live longer and healthier lives, is because they consume large quantities of these polyphenols that can help to program their immune system and their metabolic system, both of which are some of the biggest predictors of how long we live in the quality of our lives to a more balanced state.

So. Eating colorful fruits and vegetables, eating more spices and herbs isn’t just for the flavor, isn’t just for the look. It’s actually a wonderful [00:47:00] way to bring in more of these nutrients, which most people do not consume enough of, because most people eat mostly processed food. So what’s been taken out of those foods tends to be maybe as much of a risk from what we consume as the things that have been put into those ultra processed foods.

Dr. Weitz: It’s kind of interesting for a number of years, Dr. Bland was focused on another bitter of food hops and did a lot of research on with hops and developed a number of products from hops and it’s kind of interesting how he’s transitioned to Himalayan Tart Buckley. He,

Dr. Perlmutter: like, he likes bitter, but I think more importantly, he just, he likes the polyphenols, right?

Yeah. He’s kind of obsessed with how. Food is able to program our body, and our physiology and certain foods, and you brought it up, this great example, hops. So beer is bitter, but if you look at all of these different groups of foods that have somehow become popular, despite their bitterness, they tend to be accompanied by something else.

So in the case of coffee, it comes [00:48:00] with caffeine. In the case of bitter. For, or I should say hops that bitterness comes with alcohol. So people are, you know, they make these associations in their brains. What I will say is what’s interesting now we have these non-alcoholic beverages like hop water for example, or non-alcoholic beer that still gives you the bitterness without the alcohol, and they’re growing in popularity dramatically.

So. Oh, interesting. It makes me. It makes me think that maybe we are transitioning to where it doesn’t have to be accompanied by the, you know, potent brain, I should say neurotoxin, right? In the case of alcohol. Yeah. Or the added sugar that maybe we are able to just enjoy the the beverage without it having to be bad for us, which is exciting.

Dr. Weitz: Yeah. I love using herbal bitters. I use ’em with a lot of my patients to stimulate digestive enzymes and bile flow and hydrochloric acid. And I love taking some herbal bitters prior to eating to get those things going. So I think [00:49:00] more bitter foods are gonna be better for our health for sure.

Dr. Perlmutter: Bitter is better.

Just have to get over the hurdle. Bitter is better,

Dr. Weitz: you know,

Dr. Perlmutter: get over the hurdle and stop. Being only willing to eat the foods that people have processed to the point where they’re not really food anymore.

Dr. Weitz: And of course, exercise is super beneficial for brain health and brain energy and brain inflammation.

Dr. Perlmutter: Yeah, I mean, that’s an entirely separate, but I guess related topic I’ll just kind of do the main takeaways here, which are that there’s no single intervention that has been most more shown to improve brain function and even reverse aspects of cognitive decline than exercise. Kirk Erickson and others have kind of shown that the hippocampus grows in people when they do exercise regularly, which is a super cool thing to do because the hippocampus is the part of the brain that tends to shrink most along with aspects of the cortex and people with Alzheimer’s disease.

So exercise promotes [00:50:00] neuroplasticity, grows new neurons, exercise suppresses inflammation. It improves metabolic function. And these are things that most people already kind of know. So what I’ve been talking about more recently is that there’s cardiovascular exercise what we would typically think of as aerobic exercise, where we’re doing repeated motion.

So jogging is probably the best example. You know, brisk walk things where we’re just kind of doing these repeated motions that get our heart rate up but don’t completely exhaust us. And then there’s anaerobic exercises, so things that take away all of our oxygen. And that could be something like sprinting or high intensity interval training, but it could also include or does include resistance training, weight training.

What makes that super interesting to me? Is that we now understand that one of the key pathways by which exercise improves our brain health is the production of these molecules called mykines. Myokines are produced by our muscles. They actually can go to our brains and influence brain immune and metabolic pathways.

[00:51:00] And they have names like irisin and brain derive neurotrophic factor cathepsin b kind of esoteric names. But the key of it is to understand myokines molecules move that are moved to our brain through our muscles are activated by things that activate our muscles, the things that activate are skeletal muscles.

To the most significant extent are actually going to be weight training. So if you lift weight, if you do resistance training with your biggest muscle groups, which are found in your legs, you are going to have the biggest increase in some of these myokines that are linked to better brain function and potentially that can help to prevent or at least significantly mitigate risk for developing brain issues like dementia.

So all of this is to say, yes, exercise is essential, but don’t skip leg day at the gym. You’ve gotta do weight training, and you’ve gotta do leg exercises, and it doesn’t have to be giant weights on the squat rack or on the, you know, the [00:52:00] deadlifts. You can do body weight squats, you can do lunges, you can use bands.

The key though is to actually do resistance training with your muscles and in particular, your leg muscles, because those are going to produce the most of these positive signals, these myokines that may help to boost our brain function.

Dr. Weitz: Not to mention, no. Decrease your risk of falling. And they’ll increase not only muscle mass, but bone density.

So those are all important for longevity.

Dr. Perlmutter: Yeah, it’s, you know, it’s just like the Mediterranean diet. It’s not just going to benefit your brain, but it’s definitely going to benefit your brain along with other aspects of your health.

Dr. Weitz: That’s great. So, I guess, we can wrap this discussion. Any final thoughts you wanna leave us with and then tell us how we our listeners can learn more about you and the work you’re doing at Big Bold Health.

Sure.

Dr. Perlmutter: Yeah. Well, I mean, I’m hopeful that as people have listened or watched, that they’ve been able to pick up a couple of tools in terms of things that they may be able to do to help decrease their risk for developing [00:53:00] brain aging or at least slowing their rate. Of brain aging. One thing that we didn’t talk about, which I would be remiss if I didn’t bring up, is that what we inhale has a major role to play in our brain health.

And so I’ve been for the last couple of years educating on and writing about air quality as a risk factor for dementia. For depression. What we’re seeing in journals like Gemma and other top tier journals around the world is that air quality is a massive risk factor for brain health and unfortunately.

Even though in the United States overall air quality outdoors has gotten better in the last couple of decades, there are two things that have happened that can put our brain health at risk because of poor quality air. One is we’ve actually seen a relative plateau and a decrease in some places in air quality as a function of wildfires.

So that has been in spec specifically in the on the west coast of the United States. A big issue because we are being exposed to more and more days with very high levels of air pollution that are [00:54:00] linked to risk for dementia, depression, violent crime, metabolic dysfunction, cardiovascular disease, early death, all the things.

The other thing which we have much more agency over is what air pollution we bring into our homes. And so what I would say here is, this is probably the most important hidden risk factor for brain dysfunction, is what you are inhaling in your home. There’s lots I can say as to the specifics, but just recognize that if you’re creating smoke in your home, whether that’s, you know, because you’re a smoker or living with a smoker, that’s a pretty obvious one, but it’s a huge risk factor.

Or because you’re cooking things on the stove top and generating a lot of smoke, or because you’re burning candles or incense, all of these are massive risk factors for worse overall health, lung health, immune health, cardiovascular. But in my case, what I’m concerned about is. Brain health. And the other component of this is it’s not just the smoke, it is all of these chemicals that we introduce into our homes, perhaps unwittingly in terms of volatile organic [00:55:00] compounds.

So that could be air fresheners, that could be cleaning supplies that could even be cleaning out your vacuum cleaner or creating dust in your house because you’re sweeping. These are all sources of air pollution. Again, lots more to say on that. I actually started a company called Lichen Air, L-I-C-H-E-N.

A i r.com and you can learn about that on the blogs there. But the main thing to understand is to appreciate that what we inhale is a major risk factor for our brains. We won’t get into today, obviously what we put on our skin. Another big consideration, right? So our skin is a massive organ. It absorbs what we put on it.

It actually has a microbiome that we can throw off, but I think that’s probably sufficient in terms of some of the things that people can do. And then la that last piece, just to understand that if you are using incense scented candles in your home, I would say to be cautious about that because even though it’s associated with wellness, it’s having the exact opposite effect on your brain health.

Dr. Weitz: Are there any kind of candles that are safe, you think? [00:56:00]

Dr. Perlmutter: I think in order it’s scented candles are the worst paraffin, specifically soy candles, and then b wax unscented candles. So the reason for that is most candles are made out of petroleum derivatives, so that’s not ideal. Scented candles produce a bunch of volatile organic compounds that are poorly regulated and may actually introduce new molecules into your environment like formaldehyde, which you don’t want.

And beeswax tends to produce lower levels of all of those molecules, especially if it’s unscented. But the key thing to understand is if you are seeing smoke in your home, that is particulate matter and particulate matter exposure, there’s no, you know, good level, there’s no hormesis, there’s no benefit.

It’s basically a graded exposure risk. The more you inhale, the higher your risk of having health problems. Doesn’t mean, you know, you can’t light a candle, it doesn’t mean you can’t use some incense, but you also have to put that into the context of. If I’m not ventilating this room, if I’m not [00:57:00] doing this for a short amount of time you know, it’s like eating junk food.

It’s, maybe it’s enjoyable, but recognize, I think in this case it’s actually worse than junk food, but recognize that what you’re doing is actually not good for your health, as opposed to, I think, some common mythology, which is you burn some Palo Santo and you know, you do some smudging and you’re doing something good for yourself.

The exact opposite is true.

Dr. Weitz: Interesting. Even if you’re burning an herb or something like that.

Dr. Perlmutter: If there’s smoke, it’s bad for your brain.

Dr. Weitz: Okay. What about breathing in essential oils?

Dr. Perlmutter: Yeah, so there’s a bit more debate on essential oils. Certain essential oils have actually been associated with better brain function.

So lavender, for example, may be calming. Cedar oil, for example, may be able to activate the parasympathetic nervous system. The thing about essential oils is when you diffuse an essential oil, you’re actually aerosolizing a lot of molecules, volatile organic compounds. So not just the ones that you can smell, but a lot of additional [00:58:00] molecules that are found in the vehicle for that essential oil.

If any essential oil diffuser is going to decrease the air quality in your room pretty dramatically. Some of that is just the water vapor, but there’s actually this potential where if you’re using tap water, you could actually be introducing heavy metals into your local atmosphere. So the recommendation there would be if you’re going to use an essential oil diffuser to use filtered water, that can help in some ways and to buy essential oils from brands that you know are only using a pure essential oil.

I think that. Like most things in wellness, you know, there’s differing degrees of quality, but beyond just purchasing from a reputable source, Johns Hopkins recommends, and I would agree with this, using it locally as opposed to diffusing it. So if you want to have a little bit of essential oil, put it on your skin again a diluted version that’s very different from saying, I’m just gonna run this diffuser in this room for the next three hours and just completely saturate this environment with these molecules, [00:59:00] because it’s not just about what’s in the essential oil.

These molecules can react in the environment to create new molecules. Some of which we definitely don’t want to be inhaling. So I don’t want to burst everybody’s bubble when it comes to this. I think, you know, some essential oils seem like they’re fine, but I think localized use as opposed to just saying.

We’re gonna run this thing in the background for the next 10 hours. And one last thing I’ll say there is, but when

Dr. Weitz: you say localized use, you’re talking about putting little on your skin or

Dr. Perlmutter: skin. Okay. Getting a couple of spritzes, you know, in your bedroom as opposed to just running the diffuser.

Dr. Weitz: Okay.

Dr. Perlmutter: The other thing I’ll just say here real quick because it’s close to this, so air fresheners, which many people use them for the same reason as essential oil diffusers. I won’t name any brands, but the plugins, the Wix, we know those

Dr. Weitz: are really toxic for sure. Yeah.

Dr. Perlmutter: So don’t do those. I think that’s just, that would be my recommendation.

There’s no, oh, just a little bit. They’re not good. And to be honest, like I’m trying to build up [01:00:00] to have a protocol around you know, Uber drivers, taxi drivers, because you get into those cars and the little dangly tree, it’s the same thing. And so it’s. It’s challenging sometimes some of these things you can’t do anything about, you know, I understand that.

But if you are staying if you, it is in your home and you have the little plugin thing that’s pumping out this unregulated air pollution every five seconds, I would just toss it. And the same with the sprays. If you’re looking for a way to improve your air quality, if you simmer some spices on the stove top, I’d say that’s a much better option.

Dr. Weitz: What about some of the natural sprays you’ll see at you know, at the health food store? Yeah. Like vanilla spray, you know, that you spray in the air a little bit.

Dr. Perlmutter: Well, I guess I, I’ll be cautious here because I don’t know exactly the one you’re referring to.

Dr. Weitz: Okay.

Dr. Perlmutter: If it’s an air freshener, if it’s an air freshener, I would just say, generally speaking, I would’ve try to avoid it.

If it is a cleaning spray, that’s a slightly different [01:01:00] scenario. And I think one way to go there is the environmental working group. Just kind of look at their individual products and they can give you a sense as to their perceived risk with the product. But I’d say anything in the air fresheners aisle, I would just avoid.

Dr. Weitz: Great hints. I think some people are gonna be disappointed to hear that their favorite way to freshen up a room is not good anymore.

Dr. Perlmutter: You know, I’m not telling people what they have to do, but I will say there’s a lot of natural

Dr. Weitz: health people with with diffusers. Listen I

Dr. Perlmutter: totally get it right.

It’s, it feels like a nice thing. But, you know, drinking a sugary beverage also tastes like a nice thing. It just. I would just say in terms of prioritization here, an essential oil diffuser is much lower on my list of concerns than is incense. Than is, you know, anything that smokes. There’s good data showing that incense produces insanely high levels of pm 2.5.

[01:02:00] Actually, if you were to burn one gram of incense, it produces five times more air particulates than a cigarette would. So it’s not some sort of an esoteric thing. Incense is designed to smoke and so it is designed to produce air pollution in a really big way. Candles, you can mitigate a little bit, trim your wick, make sure that it’s not super high so you’re not getting the sputtering and producing a bunch of smoke and some candles can be nice.

I don’t think having a candle on occasion in the house is the issue, but go with an unscented candle. I think essential oils, you know, some pros and cons, there’s actually some literature showing that they can be beneficial. But you wind up in the same scenario, which is you gotta ask yourself, if you’re gonna be inhaling these molecules for the next four hours, how much do you trust the quality of this company, this multi-level marketing company that is really incentivized just to sell this product?

You know? So there, there are sometimes unpleasant questions to ask about the things that we use, but I think they’re necessary. [01:03:00]

Dr. Weitz: Right. Alright, great. Give up the diffuser if you so choose. Thank you Austin. So how can people find out more about you and what you’re up to? For sure.

Dr. Perlmutter: So my, best ways to get ahold of me would be My website is austin perter.com.

That’s where I have my brain health newsletter. It goes out to 170,000 people a week. For people who are interested to learn more about the Himalayan Tar Artery buckwheat research, big bold health.com, and then for people who want to, I guess learn more from me and the big bold Health team in any way, shape or form, you can find us on YouTube.

You can find us on social media. I’m on social media at Dr. Austin Protter. And Big, bold Health is there at Big Bold Health. And otherwise, I guess if you ever go to conferences, I’m at a lot of conferences speaking on these topics. So if you happen to listen to this podcast and you see me at a conference, let me know.

Dr. Weitz: Sounds good. Thanks, Austin.

 

Dr. Marcia Harris discusses Hormone Replacement Therapy with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

Reevaluating Hormone Replacement Therapy with Dr. Marcia Harris
In this episode of the Rational Wellness Podcast, hosted by Dr. Ben Weitz, the topic of hormone replacement therapy (HRT) is explored with Dr. Marcia Harris, an expert who moved from practicing allopathic medicine to focusing on wellness and preventative care. The conversation delves into the historical context and criticisms of the Women’s Health Initiative study, which initially created widespread fear around HRT in 2002. Dr. Harris discusses the benefits of bioidentical hormones, issues with synthetic hormones, and details her preference for hormone delivery methods like pellets and oral progesterone. She also shares insights on testosterone for women, and the significance of maintaining an optimal hormonal balance for overall health. The episode concludes with Dr. Harris emphasizing the necessity of hormone therapy for quality of life and debunking prevalent myths about menopause and HRT.
00:00 Introduction to the Rational Wellness Podcast
00:26 History and Controversy of Hormone Replacement Therapy
03:30 Dr. Marcia Harris: Journey to a Cash Practice
03:44 Challenges with Insurance and Medical Practice
08:19 Personal Experience with Hormone Therapy
12:06 Flaws in the Women’s Health Initiative Study
17:15 Modern Perspectives on Hormone Therapy
22:02 Preferred Forms of Estrogen and Administration Methods
29:11 Expertise in Hormone Therapy
29:43 Estrogen and Progesterone Insights
33:21 Testosterone for Women
35:25 Other Hormones and Supplements
40:38 Environmental Toxins and Hormone Disruptors
47:31 Final Thoughts and Contact Information
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Dr. Marcia Harris is an OBGYN who’s practice is focused on Wellness and Preventative Medicine and Bioidentical Hormone Replacement Therapy for both men and women. Dr. Harris primatily uses BHRT pellets. She runs the Wellness Restoration Center in New York City and her website is DrMarciaHarris.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz: Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.  Hello, Rational Wellness podcasters, today our topic is Hormone Replacement Therapy with Dr. Marcia Harris. For those who have not followed the history of hormone replacement therapy for women after menopause, a lot of the story revolves around a women’s health initiative study that was published in the Journal of the Medical Association in 2002 Women as compared to men were at reduced, are at reduced risk of heart disease due to the protective effects of estrogen prior to menopause. However, after menopause, their heart disease risk rises without the protection of estrogen. We also know that estrogen is protective of bone health, brain health, and many other aspects of health.

Prior to the Women’s Health Initiatives study, it was widely believed that hormones were beneficial in the prevention of chronic diseases and mortality, and many women took hormones after menopause. After the Women’s Health Initiative study was published, this number dropped to two to 3%. This study, the Women’s Health Initiative study concluded that women who took conjugate, conjugated, equine, estrogen, and a synthetic progestin had a higher risk of heart disease, blood clots, and breast cancer.  Doctors in the US largely stopped prescribing hormone replacement therapy due to these perceived risks. Now 23 years later, and numerous re-analysis of the Women’s Health in Initiative and many studies later, hormone therapy is now finally starting to be accepted again by mainstream medicine such as the American College of Obstetrics and Gynecology, which now generally recommends hormone therapy for managing menopausal symptoms.  Of course, with a preference for FDA approved formulations and discourages the use of compounded formulations. Today to discuss this topic, we have Dr. Marcia Harris, who went to medical school at Columbia University. She practiced allopathic medicine for her first 20 years in practice, though for the last 17 years, she’s been focused on wellness and preventative medicine and bioidentical hormone replacement therapy from both men and women.  Dr. Harris prides herself on being able to take care of the whole patient and getting to the root cause of whatever the problem is, which I would regard as functional medicine, which is the focus of this podcast. In addition, Dr. Harris runs the Wellness Restoration Center in New York City, and she successfully run a cash practice for all these years.  So Dr. Harris. Thank you so much for joining us.

Dr. Harris: Thank you for having me, Dr. Weitz.

Dr. Weitz: Yes. And congratulations for running a successful cash practice, because that’s a big achievement. Why don’t we start by, I’m just curious, what made you decide to opt out of the insurance model?

Dr. Harris: Oh, that actually goes back to when I started my OB GYN practice.  Right. I literally started, I finished my residency in 79 80, and I started the OB GYN practice. Then the first patient I delivered was the wife of the chief resident in ophthalmology at one of the New York City hospitals.

Dr. Weitz:   Okay.  

Dr. Harris: And city insurance was at the time, GHI. Now, I had spent six months getting myself into all the insurance plans, like all 35 of them, you know?  And the first check I got, which was now, I think I got the check in September. September or October. And the bill at that time for total obstetrical care was $1,800. Total Obstetrical care, we’re talking about 1980. Okay.

Dr. Weitz: Yeah.

Dr. Harris: Check from GHI was for $555 and 41 cents. Please don’t forget the 41 cents, okay?  I looked at the check and I looked at my office manager and I said, Madeline, what’s this? And she very proudly and excitedly said, oh, that’s the payment on Esther. And I said, but for what? The bill was for 1800. She says, yes, but you say you participate with the insurance and if you participate, you cannot bill for the balance that you have to take what they give you.  I said, are you kidding me? So I just took care of this woman for nine months of a pregnancy, sat there with her for 24 hours, delivered her baby, took care of her for the six weeks after. For less than a third of the going rate. I said, please, before you leave, bring me all the contracts. And I literally sat in my office and hand wrote the letters 34 times, taking myself out of every insurance.  I don’t even take Medicare. 

Dr. Weitz:  Right.

Dr. Harris:  I take nothing, and this goes back, as I said, to 1980, 45 years. 45 years.

Dr. Weitz:  Well, to be honest with you, if you got close to a third of your bill from insurance, you did incredibly well.

Dr. Harris: Well, you know, my husband, my then husband was an ophthalmologist. And at the time Medicare was paying ophthalmologist $2,200 for a cataract.  Okay.

Dr. Harris: One cataract, $2,200. I lived to see, and I’m not sure over what period of time, but I actually lived to see them now getting $650. For a cataract, right? That 2200 was whittled down over a period of time to 650. 

Dr. Weitz:  Right? And which is incredibly challenging. If you’re in practice and you, your rent goes up 3% every year and the salaries go up and everything else goes up, and then the insurance companies pay you less.

Dr. Harris: 3%. This is New York City, my rent went up 3%, 3%, 3%. 20%. 20%. 20%. I told you I just moved and that’s the reason I moved. My rent literally almost doubled.

Dr. Weitz:  Wow.  I grew up in New York, but I’ve been out in LA for a long time now. So,

Dr. Harris:  I don’t know. Is it any better?

Dr. Weitz:  I don’t know. I don’t really know how to compare, but typically we usually get a lease where the rent goes up 3%.

Dr. Harris:  Right. That’s what you would expect. Right. But they did that for three or four years and then they just, I don’t know.  I guess there was an escalation clause, which I guess I didn’t catch.

Dr. Weitz: Ah, so, okay. Well, let’s get into our discussion about hormone therapy. So perhaps you can first start by giving us your opinion observations about the Women’s Health Initiative Study.

Dr. Harris: Well, let me put it, let me start. I actually found hormones for me because I was completely non-functional.  And when I started going through menopause and I couldn’t I, my symptoms were so severe that I literally couldn’t function.

Dr. Weitz: Why? Why were your symptoms?

Dr. Harris: My, oh, especially the vasomotor stuff. Most people get four or five or six or eight hot flashes a day. I was getting 20. Right, and they were severe. I was waking up at night drenched in sweat.  I, I mean, it was really bad, right? That and my irritability and anxiety. The nurses would see me get off the elevator and they would duck into rooms. It’s like, let’s see what mood she’s in today before we. Go close to her.  Okay. It was that

Dr. Harris: bad. Okay. And I tried everything. I tried everything and everything worked a little bit for a little while, and then I had to move to something else.  And I, as I stepped it up and stepped it up and stepped it up, I [00:10:00] eventually found. The bioidentical hormones, you know, did my research, found them. I actually went out to Scottsdale, Arizona to get trained and we’re talking about, when was that? We’re talking about, I think 96, 97. So this was even before the Women’s health initiative study.  Okay. We as gynecologists at that time. I mean, I was well trained on hormones, you know, air quotes, hormones, but we were using at the time the horse’s urine stuff, right. Yeah, no, they con conjugated, equine, estrogen.

Dr. Weitz: I’m still amazed that we thought it was a good idea to give women hormones from horses.  Now you damn well know that they never prescribed horses hormones to men.

Dr. Harris: There you go. Isn’t it amazing that, you know, we’re treated like second class citizens? We’re always treated like second class citizens, and in addition to which very little of the research is done on women, right. You know, so e even with regular drugs, very little of the research is done on women.

Dr. Weitz: Yes, absolutely.

Dr. Harris: Basically the day the woman’s and you forget about

Dr. Weitz: Any research studies that are looking for grant money today that have the focus on women.

Dr. Harris: Forget it not happening, you know? Yeah. Well, the day the Women’s health Initiative study. Made New York Times and Wall Street Journal headlines.  If my phone didn’t ring 150 times, it didn’t ring once. I mean it rang off the hook. [00:12:00] Women, I mean, everybody was calling. What do we do? Right? The problem with the Women’s Health Initiative study. Now, first of all, let me backtrack a little bit. We had been, as I said, trained on hormones in medical school, residency, et cetera.  However, the. The, there were no studies. There were all observational studies. We thought we knew that it was protective of the heart. We thought we knew that it protected the brain. We thought we knew that it built the bone. I mean, we saw this definitely going forward, but there were no, you know, pro active prospective.  Going forward studies. Right. So this was a concerted effort to do that. Right. Which [00:13:00] was very commendable, you know, to get everybody to come together. 166,000 women. And we’re now going to prove that yes, estrogen does indeed protect the heart. Yes, it does protect the bone. Yes, it does protect the brain.

We, were now going to prove this so very commendable. However, the study was flawed from day one. As you know, we, they actually, first of all. How are you going to do a study on menopause and not include women who are symptomatic? Right? Women who were symptomatic were not included. So the younger women, the 40 and 45 and 50 and 55 year olds, [00:14:00] 80% of them were not eligible to be a part of the study because they were all symptomatic, right?

So the 20% who were not, or who had completed their symptoms are the ones that were included. The average age of the patients in the Women’s Health Initiative study was 64, 65 years old, right? Made no sense. So from the beginning it was flawed, right from the very beginning. Now, so the average age 65 years old, nobody with symptoms was included. Secondly the arms of the study, the estrogen arm, the estrogen and progestin arm, and that was the one that actually, that arm is the one that actually made the problem because they were using a synthetic progestin, not progesterone. So even in addition to the horse’s, urine estrogen, they literally were using a progestin.  And that synthetic progestin is what actually, it turns out after the fact is what made most of the problems. Right. So, that was, you know. Literally when and let me go one step further. When these studies are done, they are analyzed. The committees sit down, they go over them, and they write up the paper as to how they’re going to announce it.  And you know, this is what we found. They put it together and it is. Released the epidemiologist or I think he was an epidemiologist slash pharmacist who looked [00:16:00] at the data and literally went to the press. Nobody sat down, they didn’t review it. This man got up, took it upon himself to go to the press and said, we’ve got a problem.  Hormones cause cancer. So for front page New York Times, I re, I remember the day. Hormones cause cancer. I mean, I know where I was the day John F. Kennedy was killed. I know where I was in nine 11. I know where I was and what I was doing that day. The day the Woman’s Health Initiative study was broken to the world, hormones cause cancer and the panic

Dr. Weitz: for women’s health.

Dr. Harris: indescribable. It was a terrorist attack.

Dr. Weitz: Yeah, absolutely. I think it’s pretty clear there were so many problems with that study. They used oral. [00:17:00] Estrogen instead of transdermal. You got  it.

Dr. Weitz: Estrogen from a horse, which is not you got it. Same as human estrogen.  They use synthetic progestin instead of progesterone. Yes. If estrogen is protective against heart disease. Let’s say, you know, it’s protective against atherosclerosis, and now women have no estrogen for 15 years during which time they’re developing heart disease, all this track and all this buildup, and then they start taking the estrogen.

Dr. Harris:  It’s a little late. 

Dr. Weitz:  It’s totally late, right?

Dr. Harris: Which is another problem there. It was just so flawed. It’s, and

Dr. Weitz: even after all that, if you just looked at the arm of the women who took estrogen only, they had, they did fine. They did fine. Exactly. They had no increased risk of cancer.

Dr. Harris: They did fine.  As a matter of fact, we now know based on subsequent studies that you know, with estrogen alone. [00:18:00] It’s actually protective against breast cancer, right? That, believe it or not, has now been proven study, proven that estrogen alone. Now, of course, now we’re dealing with the plant-based and the bioidentical.  We’re not dealing with the conjugated equ, equine estrogen anymore. Well, wait a minute. All

Dr. Weitz: that’s still being prescribed.

Dr. Harris: I know and that’s so sad.

Dr. Weitz: I know, but

Dr. Harris: what can I tell you? Yeah I know 

Dr. Weitz: And synthetic progestins are still being prescribed as well.

Dr. Harris: I know. They, I had a patient also recently who went to her gynecologist who told her she would give it, she would give her hormone replacement, but for only a short period of time to tide her over and then take her off it because of how dangerous it is. Right. You know, and then one of my patients referred her to me, you know, so.

Dr. Weitz: You know, if you think about it just in terms of how the body works and what’s in the body naturally, how can it be the case that the hormones that have been in women’s bodies for decades that are having all these incredible functions and how our body works.  Yes. And then after menopause, putting those same hormones back in her body, suddenly they’re harmful when they were helpful and promoted health for decades.

Dr. Harris: Makes no sense.

Dr. Weitz: Makes no sense.

Dr. Harris: Our hormones, there are hormone receptors on every single cell in the body.

Dr. Weitz: Absolutely.

Dr. Harris: And our hormones are involved in almost 400 different functions.  Right. So it makes sense that when we, when the hormones decline. Every cell is going [00:20:00] to get affected. Yeah. And that’s what happens, which is why I tell patients all the time, your great-great-great grandmother and mine didn’t live past 50. The average age of menopause is 51 or 52. So by the time our ancestors were getting ready.  To go through menopause or started going through menopause, they were also getting ready to die.

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Dr. Weitz:  So when it comes to estrogen, what is your preferred form of estrogen? Do you some doctors will prescribe in the functional medicine world, they’ll prescribe transdermal  Biest formulations of estradiol and Estriol. What do you think about that versus estradiol?

Dr. Harris: Well, I’m a rebel again, because 29 years ago I actually brought. Pellets to New York City. Okay? And I know a lot of people don’t like pellets, but it’s because of the fact that they are not accustomed to them.  They’ve never been trained and they don’t know how to use them because dosed properly. There’s nothing like pellets. [00:23:00] Now that is estradiol. Do I use biased? I do. Yes, I use it transdermally or sublingual. Those are the two ways, either transdermal or sublingual. The problem with both transdermal and sublingual is it’s as if you’re on the Coney Island rollercoaster because you put it on and your level goes way up, and you’re good for 12, 16, 18 hours, and then you crash and burn again.  So you’re constantly doing this.  Okay. You know,

Dr. Harris: whereas with the pallets, your body takes it as it needs it, and it’s gradual. You build up to a level, it peaks. It basically stays at that peak [00:24:00] level until it starts getting used up. And when it starts getting used up, you make sure that they never get back to rock bottom, or they don’t get back to the foot of the hill or the bottom of the rollercoaster because you give them more at that point.  So it’s more of a steady state and your body uses it as it needs it.

Dr. Weitz: What about the patch, which has been shown to deliver more consistent transdermal levels?  Yes.

Dr. Weitz: Or a transdermal patch that’s been shown to deliver more consistent blood levels of estrogen.

Dr. Harris: Transdermal patch works. Works pretty well.  Works pretty well. The problem is with the patch. You cannot, depending on where they put it, and what else is going on, you know. You can’t guarantee. For example, if I give somebody, [00:25:00] pick a dose, I give somebody a hundred milligrams of something. I can’t tell you whether the person’s getting 20 milligrams or 80 milligrams.  That’s the only problem.

Dr. Weitz: I think studies have shown that the that the patch gives pretty consistent levels.

Dr. Harris: It does, it gives pretty consistent levels, but we don’t know whether it’s a low level, a higher level. In other words, your skin’s different than mine, whether you oiled it, whether you know, there are so many right factors that come into play, right?

Dr. Weitz:  That now when it comes to pellets. Doctors I talk to who don’t like to use pellets their objections are that it’s hard to know exactly how much a woman is gonna do, perform optimally on. And if you put the pellet in and it’s too high a level, there’s nothing you can do. There’s for three months, there’s nothing you can do

Dr. Harris: about it.

[00:26:00] Right? Well, the person, how we were trained, there is an actual formula. Where 99 times out of a hundred there, I have no problem. In the 29 years I’ve been using pellets, I’ve had a problem three times.

Dr. Weitz: Okay.

Dr. Harris: Three times.

Dr. Weitz: Okay. So now do you start low and gradually go higher, or how do you know what level to start at?

Dr. Harris: I use the formula. There is a formula which based on the person’s lab results, so we do blood tests and everybody, okay. By the way, the testing standard is blood because there’s even controversy about that.

Dr. Weitz: Of course, there is. There’s controversy about everything.

Dr. Harris: What can I tell you? There’s even controversy about that, but using blood.  Yeah, I know. When it comes to

Dr. Weitz: testing, we have blood, we have [00:27:00] urine, we have saliva.

Dr. Harris: The problem with both urine and saliva is that’s giving you an after the fact number. It’s not telling you what’s there, what’s being used, what it’s telling you. It’s giving you the metabolite after it’s been used.

Dr. Weitz: Right. Does that make

Dr. Harris: sense?

Dr. Weitz: Yes. It’s what’s being excreted by the body.

Dr. Harris: That is correct, and I was very excited, like initially with the Dutch test, which I have stopped using. Doesn’t tell, does not give me the same information.

Dr. Weitz: Well, but it does give you information that serum testing does not give you, which is how do you metabolize the estrogen?

Dr. Harris: It does it that it does,

Dr. Weitz: yes. And that’s important for, you know, overall health, isn’t it?

Dr. Harris: It is. Okay.

Dr. Weitz: So, and then some doctors who [00:28:00] use transdermal estrogen feel that saliva testing is better because they feel that it, that the, when you deliver estrogen transdermally it doesn’t show up as easily in a bloodstream.

Dr. Harris: Well, again, most of the time I do pellets. Right. So the gold standard still is blood.

Dr. Weitz: Right. Okay. And do you often find that you have to increase the dosage or you usually get the right dosage the first time,

Dr. Harris: nine times outta 10? I get the right dosage the first time. Okay. And that’s the thing with the formula about how we were trained.  Right, which is another problem because the two largest companies out there right now their training I don’t know about their training ’cause I didn’t take it. I actually have a friend, a colleague in Atlanta who started training. [00:29:00] For the largest company out pellet company out there right now.  And she lasted six weeks. She called and she, I said, how’s it going? She says, girl, I had to leave. She says, they don’t have a clue what they’re doing, and I know they don’t because I get their patients all the time, and I say, pellets, and they’re like, oh, I tried that and it didn’t work. And I said, okay. You used the right word.  Tried. You’re now, you’ve now come to the expert. I’m not going to try it. I’m gonna do it. Let’s see how you do. Okay. And 99 times out of a hundred we’re good.

Dr. Weitz: Right. Okay. And in general, do you believe in using a low level of estrogen or are you trying new supply the level of estrogen that a woman would have, say in her thirties?

Dr. Harris: No. Basically what the formula that we use [00:30:00] gives you enough to maintain you, but not take it through the roof. So, no, we’re not, I’m not trying to bring people back to their thirties.

Dr. Weitz: Okay.

Dr. Harris: That is not what I’m trying to do.

Dr. Weitz: Okay. And what about progesterone? What’s your perspective on progesterone?

Dr. Harris: I love it.

Dr. Weitz: And do you recommend oral progesterone?

Dr. Harris: I do oral because several reasons. Number one, progesterone’s a much larger molecule. So even does, it does not get absorbed properly through the skin. It’s better sublingually but still. Is best if you do it orally. Now the progesterone, the fact that orally it does go through the liver, but it also helps with the insomnia and the sleep and calming and, you know, getting rid of the anxiety and all of that type of thing.  It works very well orally because it’s a much, much larger molecule. Right. So, and even women who’ve had hysterectomies, I still keep them on progesterone. I adjust the dose based on their levels. The important thing with progesterone and estrogen is not the absolute level, it’s the ratio of one to the other.

Dr. Weitz: And what should that ratio be?

Dr. Harris: That ratio should be about 10 to one.

Dr. Weitz: Okay.

Dr. Harris: So if the estrogen is 20, the progesterone should be two.

Dr. Weitz: Okay.

Dr. Harris: If the estrogen’s 200, okay. Then, you know.

Dr. Weitz: Okay. And what about prescribing progesterone for two weeks and then [00:32:00] not doing it for two weeks to mimic the natural progesterone?

Dr. Harris: I have, it depends on the stage. Perimenopausal women, I will definitely try to cycle. Okay. Once you’ve gone through menopause, I, unless the person really wants to be cycled, I don’t. If the person wants to be cycled, I will still do it. But in general, once you’ve gone through, once you’re post-menopausal, it’s more than a year and you’re in definite menopause, we no longer need to cycle you.  I just keep the ratio, the 10 to one ratio as best I can

Dr. Weitz: to play devil’s advocate. Isn’t progesterone naturally secreted only for two [00:33:00] weeks in a month for women?

Dr. Harris: Not true.

Dr. Weitz: Okay.

Dr. Harris: The level goes up after ovulation, but it’s always there.

Dr. Weitz: Okay. But at a very low level. Right?

Dr. Harris: It’s at a lower level. That is correct, but it’s always there.

Dr. Weitz: Okay.

Dr. Harris: Now testosterone for women.

Dr. Weitz: Yes.

Dr. Harris: You haven’t touched that.

Dr. Weitz: I know That’s come, that’s the next question you read my mind.

Dr. Harris: Okay. Because you know, most women are very surprised when I tell them that they need testosterone, but that’s the man’s hormone. No, we all have, not only do we have testosterone.

Just as men, do we have 10 times less?

Dr. Weitz: Yeah,

Dr. Harris: but we have [00:34:00] testosterone. Absolutely. It’s responsible for the same things. It’s responsible for our muscle toning. It’s responsible for our energy. It’s responsible for our libido. It’s responsible for everything that it’s responsible for in the man. As a matter of fact, we have 10 times more.  Testosterone. Then we have estrogen right now. Go figure. We have 10 times more testosterone than we have estrogen. Even though estrogen and progesterone are the uniquely female hormones.

Dr. Weitz: Right. So how do you like to prescribe testosterone as a gel or what?

Dr. Harris: Nope, I do pellets again. Okay. Or injections. Or injections.

Dr. Weitz: Okay.

Dr. Harris: We can’t we shouldn’t give the testosterone orally because of the liver, you know? But [00:35:00] outside of that, it works very well, either by injection or by palate. It does. Now, lately we’ve been using it sublingually, and it looks as if that’s gonna work. As well. Okay. But no, definitely not orally.  You don’t wanna give testosterone orally.

Dr. Weitz: Okay. What about other hormones? What about DHEA? What about pregnenolone?

Dr. Harris: Now, I sometimes have to give women DHEA and pregnenolone men. I give it to almost routinely. The women. Okay. The hormone hierarchy, as you know, we see it, everything starts from cholesterol, right?  And then comes down, you know, with the andro, dione, pregnenolone, et cetera. And then it branches off [00:36:00] and becomes testosterone to the left and estrogen to the right, and progesterone down the middle, and. When it gets to that level on the bottom, they can actually, like if the receptors, one set of receptors are full, they can actually just, you know, convert to something else.  You know, estrogen can convert to testosterone. Usually it’s the other way around. Testosterone can convert to estrogen,

Dr. Weitz: right. And DHEA and OL alone are kind of precursor hormones, so they’re precursor hormones. DGA tends to, once

Dr. Harris: you’ve got the bottom ones stabilized, once you’ve got the bottom one’s, okay, 99 times out of a hundred, you don’t need the middle ones, you don’t need the precursors.

Dr. Weitz: Okay? So, what about women with vaginal symptoms like dryness et cetera? Do [00:37:00] you recommend vaginal estrogen, DHGA or what?

Dr. Harris: I use vaginal estradiol.

Dr. Weitz: Okay.

Dr. Harris: But in general, if they are balanced systemically. It actually believes it. Believe it or not, it actually rebuilds the vaginal mucosa. It rebuilds the vaginal mucosa.  Okay. Just as we know that, you know, estrogen protects and the bone, whereas testosterone builds back the bone. Right? As a matter of fact, there are studies which have shown that. Testosterone rebuilds normal, trabecular bone up to 8% per year.

Wow. Up

Dr. Harris: to 8% per year. I now have orthopods and cardiologists sending me patients [00:38:00] for hormones because they can’t tolerate the bisphosphonates or whatever the.  That stuff is that they’re giving them, that’s eating their guts out, you know? Yeah.

Dr. Weitz: Yeah, no, for sure. Hormones can be very beneficial for low bone density and fracture risk osteopenia, osteoporosis, and is probably underutilized for that. And certainly you don’t hear too many doctors talking about prescribing testosterone for women with osteoporosis.

Dr. Harris: And it works, right? It works. I have actually, I have multiple cases where I have not only maintained, but reversed osteoporosis to [00:39:00] osteopenia and back to normal trabecular bone.

Dr. Weitz: Yeah. And then of course, the importance of exercise and, several weeks ago, we had Dr. Belinda Beckon, who is the one who published the studies to lift more trials, which are the only trials that showed that heavy weight training can actually increase bone density.

Dr. Harris: Yes. It’s, it does,

Dr. Weitz: yeah. So women need to in addition to taking estrogen, progesterone, and testosterone, they also need to do heavy weight training.  And I think there’s a bunch of other nutritional supplements they should be taking as well is including vitamin D, vitamin K,

Dr. Harris: absolutely. D three and K two is, you know. There’s a, there is a whole, there is an entire list. Absolutely. I tell everybody the two things, everybody walks out of here. [00:40:00] Out of my office with is knowing their D three status and knowing their inflammation status.  Yeah, because I tell everybody, if we were to get rid of the inflammation and the vitamin D deficiency, 50% of what we treat as physicians would disappear.

Dr. Weitz: Absolutely

Dr. Harris: 50%. So that means

Dr. Weitz: vitamin D is so important for so many things. Yeah. Yep. Yeah, we had Dr. Michael Hollick, who is the world’s expert on vitamin D.  So listen to that episode. It was really incredible. So what do you think about estrogen disrupting substances in our environment, which are very common, we hear about ’em all the time. So we have pesticides, we have bisphenol A, we have Teflon, we have all these different toxic substances, heavy metals that are estrogen are [00:41:00] endocrine disrupting substances.

Dr. Harris: Well, basically. We are and I live in New York City.

Dr. Weitz: Yeah. So

Dr. Harris: I mean, just breathing the air.

Dr. Weitz: Yeah.

Dr. Harris: I am behind the eight ball, you know, breathing the air. I’m behind the eight ball. So that actually makes it even more important in terms of our. Replacement in terms of the you know, because the disruptors, I mean, I don’t know how, at least not living in New York City, I can think of places in the country, right where yes, we could get away with it.  But certainly not in this environment.

Dr. Weitz: Well, look, there’s, there are some things we can’t control, like you said, the air, but there’s some things that we can control. [00:42:00] We can have water purification systems, not drink the tap water. We cannot use plastic. We can change the personal care products. We use the cleaning products in our house, you know, that is correct.

Dr. Weitz: We, we can buy. Furniture that doesn’t inflame retardant chemicals in it. We have to, you know, there’s a lot of things we can do and then we can rev up our body’s natural detoxification capabilities.

Dr. Harris: Yes, absolutely.

Dr. Weitz: Do a detox, add some liposomal glutathione, et cetera.

Dr. Harris: Yep. My, my friend, my person gath.

Dr. Weitz: Yeah,

Dr. Harris: I actually,  Sidebar. I literally take about 30 capsules a day.

Dr. Weitz: I’m right there with you twice a day.

Dr. Harris: I literally take 30 capsules a day. I had company once and I got up in the morning and I’m putting out my, [00:43:00] I have these three little, you know, metal. Things and I’m putting out my supplements and this.  He stood there and he watched me and then said please don’t take them. I’ll be right back. Went upstairs, got his camera, came down and took a picture because he couldn’t believe and I explained what everyone was four, you know. Right. 15 in the morning. Yep. 10 after that, and like six or eight before I go to bed at night.

Dr. Weitz: Yeah.

Dr. Harris: You know, so

Dr. Weitz: yeah, no I’m taking about 30 in the morning and 30 in the afternoon with dinner. And then more, I take some before the gym, I take some before bed and then my patients come in and they go, what, you want me to take five supplements? Are you kidding me? Right. And I understand the way we feel, but.  I, I do want you to take, I feel like that’s not many at all compared to what I take.

Dr. Harris: It’s [00:44:00] not. Yeah. And I mean, let’s face it, we get very little nutrients from the food we’re eating. Absolutely. You know, when I started doing this 50 years ago, a tomato was a tomato.

Dr. Weitz: Absolutely.

Dr. Harris: Now it, it doesn’t even taste.

Right,

Dr. Weitz: right.

Dr. Harris: So you absolutely

Dr. Weitz: know it’s grown in soil that’s depleted of nutrients or maybe has some artificial you know, nutrients put back in. It’s water is used that has many toxins in it. They use a lot of times toxic fertilizers sprayed with pesticides, herbicides. Then it goes to your then it’s stored in frozen containers for weeks and months on end, sometimes transported to other countries, and and then you’re cooking it and destroying nutrients even more.

Dr. Harris: Absolutely. It’s, it really is amazing the state of the food in this country. But we won’t get off [00:45:00] topic that’s another, that, that’s your baby, and it’s another. Talk.

Dr. Weitz: Yeah. But you know, we need to eat organic. We need to try to do the best we can and then we need to try to make sure we have optimal levels of all the nutrients.  And that’s one of the reasons why we like to TaskRabbit and guessing. And you know, we have certain targets that we know. There’s studies showing that. If you get your vitamin D level up to 60, you have significantly decreased risk of breast cancer. Absolutely. You know, there’s a number, we have data showing what is the optimal ranges for these nutrients, and then we supplement till we get to that range,

Dr. Harris: Which is another problem.  ’cause everybody comes in and says, oh, my doctor says I was normal. Right? And I draw my bell curve and say, look. Arbitrarily. They put a line 15 degrees to the left and 15 degrees to the right to the left. They say you [00:46:00] don’t have enough to the right. They say you have too much using vitamin D, 30 to a hundred.  And I draw my bell curve and I say, tell me really if you are 31, are you normal? Of course not. And they look at me and say. You’re right. No, you’re right. I say you’re supposed to be, I don’t use the word normal. I say optimal. You’re supposed to be here.

Dr. Weitz: Yeah. You know, what I tell ’em is normal is what the average American is, and the average American 75% are overweight.  They have heart disease, they have diabetes, they have multiple autoimmune diseases. They’re losing muscle mass. They have low bone mass. I mean, you don’t wanna be like the average American.

Dr. Harris: I’m gonna start using that. I am definitely gonna start using

Dr. Weitz: And you know, during the pandemic when people gained even more weight and were drinking more, some of the labs actually changed the ranges and [00:47:00] raised what’s considered a normal liver enzyme.

Dr. Harris: Yes. It, and it’s funny, it took a while. For that to catch on or catch up. Right. Because right after COVID, everybody’s liver enzymes were elevated. Yep. And it’s like, what’s going on? And it took a while for them to figure out, you know,

Dr. Weitz: whats going on? Well, everybody’s scared shit less than they’re drinking like a fish.

All righty. So final thoughts and then tell us about your contact information.

Dr. Harris: Well, final thoughts really is so important that we understand stand that our hormones. Really do what they do in that they protect us. They [00:48:00] are involved in 400 functions and are therefore necessary. For example, the North American Menopause Society still has in their guidelines that you’re to take hormones for.

As shorter a period of time as possible at the lowest dose possible. Right. Which is not true. I mean, that’s almost counterproductive. I’ll be taking them until they, you know, lay me down for viewing. I, as I, I tried stopping, I tried decreasing. I was not able to, I still. If I go too long, can’t function well.

I love telling people I’ve been out of medical school for 50 years and they look at me and say, oh, [00:49:00] you’re kidding. I thought you were 55 or 60. It’s all the hormones. They really do what we say they do. They are protective. I. All the myths out there, the misconceptions, the misinformation. I mean, I swear menopause has to be the most misunderstood, for want of a better word, diagnosis in Madison.

Dr. Weitz: Have we covered most of the myths in our talk?

Dr. Harris: Well, there are several others. Okay. Once you start hormones, you can’t stop. Not true. Hormones are only for hot flashes and night sweats. Not true brain fog and weight gain is just a part of aging, not true. [00:50:00] All women go through menopause the same way.  Not true. Menopause only affects your reproductive system. Not true. Once your period stops, the symptoms are over. Not true. Okay. You don’t have, you just have to tough it out. Not true. Ladies and gentlemen, you do not have to live with the symptoms and most important hormones are not dangerous. They are not dangerous.  They are actually protective. They’re not dangerous. There are two more women are being told they’re too young to be starting menopause. Perimenopause starts as early as 39 or 40 [00:51:00] normally.

Dr. Weitz: Okay,

Dr. Harris: and the other thing, the last one. Bioidentical hormones are unsafe and unregulated. That is not true. The compounding pharmacies are probably better regulated than the regular pharmacy.

Dr. Weitz: And even if you didn’t want to use compounding pharmacies, you can take the FDA approved patch and you can take bioidentical progesterone pills that are

Dr. Harris: progess. Yeah. FDA approved as well. Yes, that is correct. That is correct. But it’s really it’s so important and we’re playing catchup.

It’s actually finally with Halle Berry and Nicole Kidman and Reese Witherspoon and Oprah. That finally they’re starting to listen [00:52:00] to women, right? Because we have been treated like second class citizens. Yeah, and there is. You don’t have to live with it ladies. There is no reason for you to suffer. There is no reason to feel for you to feel like not a person when there is good treatment out there for you.

Dr. Weitz: Tell it to us, Dr. Harris. That’s good.

Dr. Harris: Yes. So I can be found at the Wellness Restoration Center in New York City. I’m on Madison Avenue, 575 Madison Avenue, 23rd floor. And. What’s the number? 646-478-9833. I don’t use it. I don’t remember it. 6 4 6 4 7 8 9 8 3 3. The website is my name, Dr marcia harris.com.  6 4 6 4 7 8 9 8 3 3. And yes, I do virtual. Consults and everything as well.

Dr. Weitz: That’s great. Thank you so much, Dr. Harris.

Dr. Harris: Thank you so much for having me.

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Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcast or Spotify and give us a five star readings and review.  As you may know, I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and want to promote longevity. Please call my Santa Monica Weitz Sports chiropractic and nutrition office at 310-395-311 1 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Dr. Andy Franklyn-Miller discusses Plant Peptides with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

In this episode of the Rational Wellness Podcast, Dr. Ben Weitz talks with Dr. Andy Franklyn-Miller, Chief Medical and Innovation Officer of Nuritas, about the emerging field of plant-derived peptides. They discuss the new category of nutritional supplements called plant peptides and its implications for health and nutrition. Dr. Miller explains the significance of peptides, their function in the human body, and the AI-enhanced discovery methods employed by Nuritas. The conversation covers the specific benefits of various peptides, including Peptistrong for muscle building and recovery, Peptisleep for improving sleep quality and heart rate variability, and upcoming peptides for anti-aging and blood sugar control. The episode also touches on innovative applications in functional foods and potential future research directions. Dr. Miller shares insights into his clinical trials and discoveries, emphasizing the potential widespread health benefits of these natural compounds.
00:00 Introduction to the Rational Wellness Podcast
00:26 Exploring Plant Peptides with Dr. Andy Franklyn-Miller
03:59 Understanding Peptides: Basics and Functions
05:30 Dr. Franklyn-Miller’s Journey into Peptide Research
05:35 Clinical Trials and Findings on PEP Strong
08:26 The Role of mTOR in Muscle Preservation and Growth
14:21 Synergistic Effects of PEP Strong with Other Supplements
18:15 PEP Strong’s Impact on Bone Density
22:47 Introducing PEP Youth for Skin Health
24:29 The Science Behind Oral Peptide Effectiveness
27:16 Challenges in Ingredient Selection and Modification
28:16 Patenting Natural Peptides
29:52 Introducing Pep Sleep: A Revolutionary Sleep Aid
30:42 Clinical Trials and Results of Pep Sleep
31:58 Heart Rate Variability and Sleep Quality
34:31 Athletic Performance and Recovery
35:37 Peptides and Nutrient Absorption
39:27 Exploring Anti-Aging and Glucose Control Peptides
44:04 Future of Functional Foods and Peptides
48:55 Conclusion and Final Thoughts
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Dr. Andy Franklyn-Miller is the Chief Medical and Innovation Officer for Nuritas, the world-renowned pioneer in AI-based peptide discovery. The website for Nuritas is Nuritas.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Today our topic is plant peptides, which is a completely new category of nutritional supplements, and we’re here with Dr. Andy Franklyn-Miller. Many of us in the functional medicine world, both doctors and patients are aware of peptides, which are signaling molecules similar to hormones that have many effects in the body.  Some of the more common ones prescribed by longevity doctors are BPC 157 growth hormone stimulators like Ilin, Sermorelin, CJC 1295. However, there are a number of commonly used drugs that are also peptides. Insulin is a peptide. This first discovered peptide.  The super popular GLP-1 agonist drugs like ozempic are also peptides, but all of these peptides are derived from animals and generally need to be injected.  But now we have peptides derived from plants, including PeptiStrong, which is derived from fava beans, which has been developed by Nuritas and is taken orally. I became aware of this product because Designs for Health is distributing it, and I’ve been taking it for the last six months to enhance my weight training work workouts, and have been noticing its muscle building effects.

Today we’re joined by Dr. Andy Franklyn-Miller. He is the Chief Medical and Innovation Officer of Nuritas, the world renowned pioneer in AI based peptide discovery, and of course, AI based everything today. Right. Dr. Franklyn-Miller has a PhD in biomechanics. He served in the Royal Navy and Royal Marines for 16 years.  He has extensive experience in working with high profile sports teams and elite performers. He’s published more than 60 peer review papers, so thank you so much for joining us, Dr. Franklyn-Miller.

Dr. Franklyn-Miller: Ben, it’s an absolute pleasure. And I love the shared enthusiasm about peptides and what they can do for everybody, be it the top performing athlete or in fact almost everyone from hospital all the way through to to everyday performers.

Dr. Weitz: And we’re all looking for an edge. And perhaps these plant peptides are one of the ways we can find that edge.

Dr. Franklyn-Miller: You know, you are absolutely right and I think, you know, you allude to it earlier. You know, pharma have discovered a number of peptides that suit their purposes. Although they’re heavily modified, they’re heavily modified for half-life or for function, or for cell penetration.  At Nuritas, what we do wouldn’t be possible without AI. And let me just try and explain that because this is not chat GPT.  This is not a large language model. What we’ve been able to do is shortcut the search and find mission that we would have otherwise by being able to handle huge data sets.  And over the last 10 years at utas, what we’ve been doing is looking at the peptides within various food grade plants, and they exist all over, trillions of them in the plant kingdom.

Dr. Weitz: Do you know what, just for a second, could you just explain to everybody who’s not aware, what is a peptide.

Dr. Franklyn-Miller: A hundred percent.  So look, what is a peptide? A peptide is a protein. It’s a short sequence of amino acids, usually somewhere between six and 30. They can be a bit longer, they can be a bit shorter. When we get really small, we talk about small molecules. They’re not peptides anymore. But what these do. These, as you said earlier, they signal, so they upregulate or downregulate pathways in the human body because they’re recognized, they bind into a receptor, and they do something.  And that’s one of the common fallacies.  Often you see peptides with multiple different potential benefits, and that’s tricky because these things are pretty specific. Although insulin as a hormone, as a peptide, or a hormone in the body. It has different effects. They’re up and downstream of its binding and you know, some of the synthetic peptides you were talking about earlier in terms of functional medicine and how they’re prescribed.  There’s often multiple different benefits as given to the same peptide, and we know that can’t be true. There have to be up and downstream effects and secondary effects because the thing about peptides, they work really quickly. They’ve got very short onsets, they’ve got short halve lives, and then they’re broken down to amino acids in the body as normal proteins.  And so these things are very specific and very detailed in their effect.

Dr. Weitz: How did you become interested in researching peptides?  

Dr. Franklyn-Miller:  Well, you know, it’s a funny story. So, so I’m a physician and I was running a large orthopedic clinic and I carried out a human clinical trial for Nuritas with their ingredient, PeptiStrong.  And I was a skeptic, as most physicians are. And I actually set this trial up to fail. It was a trial of 30 adults trained athletes and it was a randomized controlled trial of a placebo or peptistrong looking at power. And we know over the weekend there’s a significant amount of work being done on power as a longevity measure.  It supersedes that of strength or muscle mass alone. We know it’s responsible for about 22% of all cause mortality. So if we can get power, and by that I mean applying strength across a joint angle or a movement we can get those…

Dr. Weitz: essentially being able to lift more weight or lift a weight more times.

Dr. Franklyn-Miller: A hundred percent.  At the very basic level, something like a sit to stand test, how many sit to stands can we complete in a period of time?  Or as you say, can we deadlift or power clean a weight off the floor? It’s movement across an angle or a multiple angles if you look at a compound lift, so functional strength really rather than just applied strength.  So they wanted me to look at the ingredient pep strong against placebo to look at the effects of fatigue. So they asked me to induce muscle damage in a bunch of trained athletes, and we did that in a cybex dynamometer. We induced fatigue by a repeated measures protocol one that I would use for elite athletes to judge, let’s say rehabilitation after ACL reconstruction.  We induced muscle damage and fatigue, and then we measured the recovery.

Dr. Weitz: How did you induce muscle damage? Was that with eccentric contractions?

Dr. Franklyn-Miller:  A combination. So we did a concentric, an isometric hold, and an eccentric contraction in leg extension, repeated times across multiple sets.

Dr. Weitz: Okay.

Dr. Franklyn-Miller: And actually, funnily enough, someone recently commented that the dropout rate from screening to test was 30%.  Because trained athletes don’t like that sort of test, not coming day to day. So it was a, it was designed to induce muscle damage, and we looked at the effects at 48 hours and 72 hours after that damaging test comparing Peptistrong, the ingredient, to placebo. And let me just tell you a little about Peptistrong.  You you, as you say came from Fava Beam, but it’s actually a series, it’s a network of peptides within it, so it’s extracted using a production mechanism that’s proprietary to neuro tests. And it contains a group of peptides that upregulate mTOR in protein synthesis, a group of peptides that regulate.

Dr. Weitz: And we’ve heard alot about mTOR as something involved in longevity and even the inhibition of mTOR as being something that could be a benefit to aging and mTOR, as we know. Yeah. Big growth thing.

Dr. Franklyn-Miller: Yeah. You’ve got the, you’ve got the multimillion dollar question. How can Upregulating mTOR. And also downregulating it, downregulating mTOR be the same thing.  And look, let me tell you the Downregulating mTOR studies are all neurons. So they’re all in mice. [00:09:00] Because the thing with longevity studies, and you know this as well as I do, it’s very difficult to do a longevity study in humans because we lived to live for a long time. Yeah, absolutely. So mice are easy.  The thing about mTOR, if we eat protein. From any source plants or animal? We upregulate, mTOR. The way that happens is leucine and arginine, the two amino acids, they drive mTOR at the top. It’s a little bit like sand into a hopper. You can shovel as much sand in as you like, but the rate limiting step.  mTOR itself, so you can feed protein at the top end, but mTOR is regulated

Dr. Weitz: And by the way, this has led some prominent researchers to say that if you really want to promote longevity, you need to reduce protein intake.

Dr. Franklyn-Miller: Absolutely right

Dr. Weitz: Or in fact, to make it a little more complicated, those same researchers say you want to decrease protein intake until you hit age 60, and then you want to increase protein intake.

Dr. Franklyn-Miller: Absolutely because the critical data here is what do the meta-analyses that the composite studies tell us about muscle mass. Longevity because they’re the studies we really have to reference. Now, that’s where the challenge comes in, because ultimately at that age, and we look at sort of over seventies, the biggest correlation is the more muscle mass you have, the less likely you are to die.  And that’s where the all cause mortality drops really sit. Now that doesn’t work. If you look at the rapamycin mTOR crowd, right? It will tell us we should slow down mTOR. In those circum certain circumstances, I think my advice stands if everything’s right in your life, you’ve got at least 1.3 to two grams per kilogram of body weight, of protein intake.

You’ve got your training life and your sleep sorted, then you can worry about mTOR downregulation. Until that point. It’s very difficult to ignore the meta-analysis evidence, which says more strength, more power, more muscle mass will treat you much better than trying to fiddle around lowering it. And so within Peptistrong, we have a group of peptides that upregulate mTOR.  We’ve also got a group of peptides which will up upregulate ATP production within the cell and another group who work via two gene transcription pathways to prevent muscle breakdown. So it’s not just a purified peptide, it’s a group of peptides. They come from fava bean and we don’t concentrate it.

Why don’t we concentrate? Because we want to be in a category which is not pharma. This is FDA GRAS approved. It has a letter of no objection. And why is that important to us? Well, our mission at Neuritas is to improve the lives of billions of people. We want to improve access. We want to make this, ingredients for food, which everyone can get hold of and everyone can use. And price isn’t the barrier. But also that the effects can be seen by many. And so that’s why our mission isn’t about synthetic peptides. This is all about what we can find within food grade natural sources, and we can treat it in a way that we can unlock the peptides.

Dr. Weitz:  I noticed in some of your articles talking about the inhibition of myokine, which we’ve heard about before, seeing these pictures of these extremely muscular bulls that have no myokine Pro or extremely restricted myokine production. They get just incredible amounts of muscle. Can you men talk a little bit about that as one of the factors.

Dr. Franklyn-Miller: Well, absolutely. So, Rogen one and Murph one are gene transcription agents which which essentially cause the breakdown of muscle. By inhibiting their action, we can preserve the muscle we have. Now, this is very different from the anabolic effect of. Of mTOR, this is the preservation, and this is where really Peptistrong has a role as maintaining the aging muscle without the need for training.  So this is a a preservation study if you like, a preservation effect. And actually the first clinical trial with Peptistrong looked at just immobilized limbs of 30 subjects in Plaster Paris for an entire week. And then followed them. With just self mobilizing exercise for two weeks afterwards, and then looked at the muscle loss, but also the protein synthesis in the group and found the pep strong group.  Were four times greater at FSR protein synthesis than the placebo, which in that case was milk protein. But to go back to action, one and one. We have peptides that will block or limit the transcription of that. So to prevent the breakdown of muscle so that you’re hanging onto what you have as opposed to just relying on building.  And of course we know that over 60 it becomes a little bit harder to trigger mTOR with, sorry, with leucine and arginine. And so as we age, it’s even more important to hang on to what we’ve got.

Dr. Weitz: Now I’ve seen where you have some studies showing that PEPs strong is more effective, say than whey protein.  What about using PEPs strong with whey protein or with branch chain amino acids or with creatine? Do we know if there’s a synergistic effect of adding some of these compounds together?

Dr. Franklyn-Miller: Absolutely. We’ve just finished a paper where we’ve been doing exactly that and I guess it’s synergy and superiority.  What we looked at in cells, in muscle cells was whether or not we could upregulate the ribosomal S6. Assay in the biology lab. So could we measure, and that’s at the bottom end of mTOR because one of the things about Peptistrong, it doesn’t compete with protein, so it’s not fighting at the top end of the arginine leucine.  It’s pulling through a little bit like the hopper. So you can put as much sand in the hopper the as you want. Peptistrong is speeding up the production along the way. So we looked at, compared to Leucine, we looked at Peptistrong compared to HMB, we looked at it compared to whey and also Reine. With Leucine, there was a superiority in both young and old cells, and what was particularly interesting was the superiority in old cells, because obviously as we get that stickiness of mTOR over 60, we Peptistrong worked independent of that stickiness.

So it would still upregulate S six between two and four times greater than leucine alone. When we look at HMB 1.6 times superiority again, so at that phospho S six and a synergistic effect of over 70%, so you could replace or you could combine [00:16:00] when it came down to whey protein. Again, four times superior at S six phosphorylation.  Creatine was really interesting. We know that Creatine is not great at muscle building on its own. It’s very much focused on a TP. The interesting thing with Peptistrong compared to creatine was that we upregulate mitochondrial a TP, unlike that of creatine. So again, we have a synergistic effect of energy.  Of the two together, they don’t beat each other, so Creatine doesn’t beat pep strong. Pep strong doesn’t beat creatine. Obviously outside of that phosphorous six. Really interesting, slightly different mechanisms of action, upregulation of energy, and certainly many of the early adopters of Peptistrong, particularly in Europe, really were formulating as an energy product first rather than that anabolic product second.

Dr. Weitz: Interesting. So the current recommendation is to take four capsules of Peptistrong per day, is that correct?

Dr. Franklyn-Miller: Absolutely. It’s 2.4 grams. And there’ve been many questions about can we divide the dose? What’s the best time should you take on an empty stomach?  Certainly the use cases have varied, are all over in and indeed in Brazil,  Where we sell via compounding pharmacists there are far there are physicians who have prescribed much higher doses and also much lower doses. And what we found is that taking it on an empty stomach is certainly superior because these peptides have to be absorbed and they survive the gut.  Within the ingredient itself, there are many peptides that are broken down that protect pep strong. Actual the ingredient parts, which are the active peptides. So taking on empty stomach is optimal and you can certainly divide dose. It doesn’t need to be immediately before training. The way that this is distributed really gives you the benefit whether as long as it’s taken daily at 2.4 grams.

Dr. Weitz: Yeah, I’ve been taking four capsules in the morning on an empty stomach before I work out, along with branch chain [00:18:00] aminos. And then I usually take something that stimulates nitric oxide at the same time.

Dr. Franklyn-Miller: Absolutely makes an awful lot of sense, and it’s a very nice combination. Commonly what we’ve seen is a lot of people starting to take with creatine and pep strong for their energy synergy effects.

Dr. Weitz: Now I saw that it also helps with bone density or strength as well as muscle strength.

Dr. Franklyn-Miller: Off. Last clinical was the first clinical we included women. And here we had 60 subjects men and women, and they carried out, they were training novices. They carried out a two month training program three times a week in the gym.  For the first time we monitored their protein intake, so it was matched between the two groups. And we saw that they increased strength by 17% in the Peptistrong group compared to placebo and muscular energy. Interestingly, in this group, and I have to say this wasn’t a part of the clinical trial protocol, we carried out a DEXA scan.  And we saw a [00:19:00] nwt 0.6% shift in bone mineral content in favor of the PeptiStrong group. And it was an observation that we didn’t expect. I can’t absolutely explain how, but that NWT point, 6% shift in bone mineral content really equates to vitamin D in calcium supplementation for a year. So a two month supplementation of Peptistrong has that effect.  I have my thoughts. We looked at a number of bone myokines. Particularly osteo and we saw elevations in osteo, and it makes sense as to how it’s happening, but I can’t yet confirm it. And we haven’t had a second study yet to to show you.

Dr. Weitz: Well, it’s interesting. I recently had Dr. Belinda Beck on the podcast, and she is the only one who’s published studies showing that you could increase bone density with a weight training program.  And she found that you needed to do heavy weight training, like five sets of five reps of exercises like deadlifts and squats, along with some ballistic loading. So it would be interesting you might. Considered trying to see if you can team up with her.

Dr. Franklyn-Miller: Yeah, AB absolutely. And I think that’s one of, one of the real confounders, like this was a novice exercise program.  It was three sets of eight to 10 reps. When we looked at the training diaries, although we would’ve liked it to be progressive overload, it was far from it. I mean, they were novice exercises, right? They all got stronger, which is good. They all got and obviously the placebo group got stronger.  We’d expect it. But there were significant differences between PeptiStrong and the placebo. We’ve just published that in the British Medical Journal Nutrition Journal. But you are right, typically bone mineral density changes need heavy al load. It’s that compressive load which gives that stimulus for change.  And it would be really interesting to see what we can achieve Peptistrong plus an optimum Regi and I think that’s really where we want to go.

Dr. Weitz: It looks like some amount, as long as it’s tolerated of ballistic loading as well, is seems to be very important for increasing bone.

Dr. Franklyn-Miller: A hundred percent.  It’s the it’s the I think you have to put the bone under sufficient stress in order to stimulate that osteoblastic activity, but at the same time, obviously not too much stress. Right. To start to develop stress response. Right.

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Dr. Weitz:   So I noticed you also have a product for skin called PeptiYouth.  Can you tell us about this peptide?

Dr. Franklyn-Miller: Peptiyouth is a really interesting peptide. We actually discovered this in the root of the pea  plant and in the root of the pea. It’s this peptides evolved for many years to protect against frost damage. So it exists in the, in its natural state as a protective peptide in that space.  It, what we did was sort of take that identical peptide, synthesize it and see what we could do in skin, because what we found is that it upregulated collagen synthesis. Remarkably well.  And a different effect, obviously then in the p but a beautiful story nonetheless. And we’ve two human clinical trials with pep youth, where we’ve looked at wrinkles at skin hydration at the smoothness of skin and also dark spots.  And found significant improvements in all four. Typically peptides on skin have quite a high inclusion rate. They have to be quite concentrated and delivered in quite high doses. Peptiyouth is effective at 35 parts per million. So it’s a really trace [00:24:00] benefit. Within that with a very nice story of naturality.  One of the really interesting things though, with Peptiyouth is the synergy with retinol with vitamin C, allowing you to use much lower doses of those other compounds, which can often be quite toxic to the skin. So use is a, is an enabler of. Increased activity decreased inflammation, but also enables the effect of retinol in particular to be significantly greater at collagen production.

Dr. Weitz: So speaking of r rates of the type of absorption most of the peptides that are on the market now are injectable. And it’s generally understood that. If if you take them orally, they get broken down into amino acids and much like eating a steak and that they are not that effective.  So how are your peptide products, which are generally taken orally except for this product, which is done transdermally? How [00:25:00] can they be effective, taken orally and or would they be even more effective if they were injected?

Dr. Franklyn-Miller: And absolutely Ben, and this is where AI comes in, so, so let me give you an analogy.  If we take a million seconds in time and look backwards, that takes us to last week. If we take a billion seconds and look backwards, it takes us back to 1994. If we take a trillion seconds, takes us back to the early ice age. What AI has enabled us to do at neuro tasks is look at a billion data points across our unique data set of peptides and look at those billion data points within two hours.  It’s that level of our ability to look at data, enables us to find the peptides which will survive the gut. Because if we had to do this by chance, it would take us tens [00:26:00] of years because we would experiment with one. We’d get that far, then we’d find it was degraded. We’d have to look at a different variant and peptides.  As you know, homologs exist in nature, so it might be one or two amino acids different from its parents, but actually a obeys many similarities, but might be much more resistant to the gastric conditions and geal absorption than the parent. If we had to look at all of the homologs for one peptide each time, we wanted to look at a potential ingredient.

We still wouldn’t be here as a company. And so that’s the part that AI has enabled us to unlock. It’s costs a lot of money to build that data set. It’s not, as I was saying earlier, this is not a large language model trained on public data. This is all hand biological lab data that’s been generated firsthand in Dublin and is proprietary.

This data doesn’t exist. You know, if you take a look, start to look at the peptides available. I’ll use a carrot as an example because there’s no, there’s very little in the way [00:27:00] of useful peptides and a carrot. But if we took a carrot and started to try and describe it, it doesn’t exist. We have to start from scratch, so, so the modeling in and around peptides, for example, that will be absorbed in the judge.

We’ve had to do that by hand. We’ve had to start work out which characteristics will absorb, which will be protected. That way when we select an ingredient, and we do this in a number of ways, we might look at an end result. So we might want to block a certain receptor or we might just want to improve muscle health.  We need to be able to select in and select out various categories to be able to get there. And pharma would like to do the same. And we can see now actually some of the oral GLP one agonists appearing that will survive. Those peptides are heavily modified to get there. In our world, we can’t modify.  So we have to find those naturally. And obviously if we can [00:28:00] modify them and get there, we can find them naturally. It’s just at times they’re locked away in nature and need to be unlocked within that plant source.

Dr. Weitz: And of course they’re motivated to modify them anyway ’cause then they can be patented.

Dr. Franklyn-Miller: Yes.  And that’s again, I guess where we have a similarity in that we’ve been very successful in patenting peptides that we’ve identified. Pep Strong is heavily patented across the world because these peptides, although in nature. Need to be unlocked via a process of that ingredient production that’s again, proprietary to Nuritas.  So these don’t just appear and others have looked at different hydros of Fava Bean and not found the same benefit. So there’s a uniqueness of production, which protects us and has given us patent protection.

Dr. Weitz: I see. So there patented because of the way you came up with them?

Dr. Franklyn-Miller: Absolutely. So although they happen to appear in that long language of code within [00:29:00] the.  And probably somebody somewhere in the world has the right digestive enzymes in order to extract them. The way that we do that to make them available is totally unique. And as such, therefore the peptide and the homologous daughters and sons in and around that peptide have been successful for us to gain pattern protection.

Dr. Weitz: That’s kind of interesting ’cause it’s generally thought that. Products that are naturally present in, in our food are not patentable.

Dr. Franklyn-Miller: Absolutely. And I think it, you know, if you kind of think of of word puzzles where the words that are hidden away within a mesh of other words until it’s extracted, it’s not a word.  It’s a jumble of letters. Right. And that’s exactly the same here in terms of peptides. It’s a bunch of amino acids in sequence until it’s cut out of its parent. And the way that we do that to produce those ingredients is the unique part of this.

Dr. Weitz: Interesting. Looking at your website, I noticed some of the other peptides that you are talking about, including [00:30:00] you, there’s mention of one for sleep, an anti-diabetic peptide, an anti-aging peptide, and an anti-inflammatory.  Do you want to talk about some of your peptides to come?

Dr. Franklyn-Miller: Absolutely. Look the latest release, and we released this just a month ago or so, is pep sleep. Okay. This is a really exciting peptide network which targets the orexin receptors. So the orexin receptors are in the adrenal cortex just above the kidney.  They released cortisol and so rather than like melatonin trying to suppress sleep, what we did here was really try to lower cortisol. And see if we can affect the diurnal rhythm in a much better way. I finished a clinical trial in December and we took 30 subjects, placebo versus 250 milligrams of pep sleep.  And we used the lead sleep evaluation questionnaire. The lead, I think it’s

Dr. Weitz: better if you lean in a little bit. Ah, sorry. Yeah, you get pretty dark to see. Sorry.

Dr. Franklyn-Miller: Yes.

Dr. Weitz: So, [00:31:00]

Dr. Franklyn-Miller: so again the lead sleep evaluation questionnaire, so. There are two questionnaires in the world measuring sleep that have been validated for clinical studies.  The leads in the Pittsburgh the Pittsburgh is really designed to diagnose a sleep disorder, whereas the pharma world uses the lead sleep evaluation questionnaire for a variety of reasons. We picked the harder the leads. And then what we did was we equipped all of these subjects with aura rings so that we could look at their heart rate variability.  We followed them for two weeks naturally, and then a further six weeks taking placebo or peptic sleep. One of the really exciting things we found was rather than just affect sleep initiation, we affected all four quadrants of sleep. So we improved sleep quality, improved behavior before waking and behavior on waking.  So no hangover effects, no feeling groggy in the morning. We induce sleep faster. The quality of sleep moved significantly up. And we saw the [00:32:00] same with heart rate variability. So again, I’m sure many of our listeners are very familiar about heart rate variability, but in essence it’s our fight or flight.

So if we take our pulse measure, our heart rate, we might average it out across a minute to be 60 beats per minute. But in fact, our electrical activity is jumping from each beat to beat, and it’s called the RRR interval. When we’re super stressed, we’re about to be run over by a truck. Our RR interval narrows, it’s our stress response and it’s driven by cortisol.

When we’re most relaxed, we’ve had the best quality of sleep. Our RR interval is wide. We vary our heart rate variability. And so what we wanted to look at was that as a metric. It’s called R-M-S-S-D, and we saw significant increases in that variability with treatment with pep sleep, and that fits with the measures.  So we had an objective measure. Which is the ring and heart rate variability. We had a subject measure, which was the lead sleep evaluation questionnaire. So we’re really excited about that ingredient. It’s [00:33:00] launching in some pretty early movers and some pretty big sleep specialists across the the us in the months to come.  But totally natural product, no hangover effect, really small dose and certainly comparable in getting to sleep compared to melatonin, but without any of the side effects.

Dr. Weitz: When will practitioners like myself be able to get

Dr. Franklyn-Miller: this I’m pretty sure there’s something coming your way in the next month.

Dr. Weitz: Okay. Yeah. Good good. It’s really

Dr. Franklyn-Miller: exciting. It’s probably one of the most exciting ingredients that we’ve seen certainly in terms of clinical trial results. Having, and it works from the first dose. And in fact, many times I’ve just said, look, it just works. And when we launched it, some of the trial samples that were out there and people came back the same day from, but gimme more.  It’s just it’s just too good.

Dr. Weitz: When it comes to sleep products, people are always afraid, am I gonna build up a tolerance? Should I take it regularly or is it gonna stop working?

Dr. Franklyn-Miller: Absolutely. And so, so I think one of the interesting things we saw was there was no tolerance. After six [00:34:00] weeks of everyday use, I.  So it wasn’t that the effect started to wear off. It wasn’t effect, you know, it didn’t seem to build any form of resistance. And we followed the subjects for a week after the trial and they didn’t seem that there was any dependency. So, so people weren’t coming back, needing to take their capsules a again.  Currently it’s formulated as a gummy, it’s formulated as a ready to drink shot and a capsule. Obviously the, our customers are formulating in. All sorts of end formulations with this.

Dr. Weitz: That’s great. And we’ve been talking about athletic performance and you mentioned heart rate variability. And decrease in heart rate variability means that an athlete will not be recovering from his workouts as well.  So if this increases heart rate variability, then not only are they gonna be sleeping, but they’re gonna better recover from their workouts.

Dr. Franklyn-Miller: I absolutely bet, and you know, it’s one of the things that actually a lot of the, a lot of the athletic brands are starting to [00:35:00] notice and start starting to talk about bringing out ranges that are devoted to that whole performance, recovery and sleep being that critical element.  I’m surprised many haven’t already actually, because, you know, if you think about it in terms of all round recovery. It’s pretty well known and pretty well adopted that sleep is the critical moment, I guess in many cases. There’s no new ingredient until pep sleep to really fulfill that window without getting it into pharma.  And I think that maybe that was the problem but certainly I think we’ll see an explosion of use. In and around that recovery, get ready to perform space that, that people are really keen to look at.

Dr. Weitz: Now, there are specialized ways to increase absorption of nutrients taken orally. So in, in our space, there’s particular companies and scientists who have perfected how to do liposomal formulations, and there’s various ways to try to [00:36:00] increase absorption. Is that something that’s beneficial for these peptides or are they already absorbed at a pretty high level?

Dr. Franklyn-Miller: It’s a great question, Ben, and I’m gonna say watch this space.  So it’s something we’re looking at right now in terms of peptides, and it’s interesting if we look at probiotics and the gut flora, you know, we’ve all seen that explosion of product on the market, about improving gut health, improving digestive health absorption, leaky gut. And then the timing of supplements.

One of the interesting things is outside of having more bacteria or a broader diversity of bacteria, not much has happened in that space. And when you look at the clinical trials in terms of around, do they make us healthier very often, it’s pretty non-specific. We don’t really know what having more of those bacteria do outside and make us feel a bit better.

And we’ve been looking at into that space quite a lot. And what we find [00:37:00] is many of those probiotics, their actual mechanism of action is peptide derived so that there are peptides delivering. The leaky gut or the rate of absorption across geal cells. So it’s a fascinating area that we’re looking at the moment, not only about the increased absorption of our own ingredients, but also how peptides can increase absorption.  Or in some cases decrease the rate of absorption. Well, that’s it.

Dr. Weitz: A lot of times you don’t want it absorbed until it gets into the colon, for example, where most of the microbiome is. And that’s a big issue. How do we keep these probiotics from getting broken down in the stomach and somehow staying intact until they get into the large intestine?

Dr. Franklyn-Miller: Absolutely right. And you know, it reminded me of many years ago, I. My, my background training is sport and exercise medicine. And I never really used to go to the sport and exercise medicine conferences and people would say, why? They go, well, I’m not gonna learn anything really from here.  It’s [00:38:00] regurgitation of fact from elsewhere. And I would favor the sort of the European Immunology Conference or the Japanese cardiology conference because. There you find clues that you can bring back to your own space. And I think that’s really what we’re looking at. We are an ingredient company.

Identifying ingredients for use in all of the NCD health verticals where we want to improve access. I. But the answers don’t lie necessarily in peptides themselves, but in other areas of medicine that we can take and say, well look, can we find a peptide which will regulate this process? And then can we find it from our own library?

And that’s really the thing that’s exciting. You know, my job in some ways is relatively easy. I have to produce two new ingredients a year. One at the side, one at the end run them through clinical trials. Currently, our success rate with magnifier, our AI platform is 80% successful at identifying a peptide or a set of peptides that have a function that we can track.  And our clinical trial success in the last [00:39:00] 18 months has been a hundred percent. So, so I’ve got a embarrassing wealth. Of peptides and potential functions. My, my biggest challenge is what not to develop rather than what to develop.

Dr. Weitz: Very exciting. If you want to team up with somebody on the liposomal front, the guy to talk to is Chris Shade, who runs the Quick Silver Scientific.  He seems to be the expert at being able to properly design a liposome. Liposomal.

Dr. Franklyn-Miller: Yep. Sounds fascinating.

Dr. Weitz: What about the anti-aging peptide?

Dr. Franklyn-Miller: A little bit ring-fenced in, in what I can say. Okay. It’s a collaboration with a a large company. So I’m a little hamstrung. What I can tell you is our glucose peptides.  So this peptide network is gonna come out later in the year. It is a pretty clever set of peptides aimed at really trying to lower the gi. Impact of food. So, so we know that high circulating levels of [00:40:00] sugar cause inflammation, that secondary effect can co go on to cause cardiovascular disease.  And. Also, we know that actually you can make some high and low GI choices in your diet, but they’re exclusion choices. You know, you are deciding not to eat carbohydrates, or you are deciding to avoid your favorite snack or your favorite breakfast or favorites. I mean, because you’re aware of the health consequences,

Dr. Weitz: correct.

Dr. Franklyn-Miller: And so we, we have a network of peptides that approach this in two different ways. One of those network are DPP four inhibitors. And so they affect the breakdown of glucagon in the liver and insulin production. On the other hand, we have a network of glute four uptake peptides, which will drag glucose into muscle cells.  And so the two balance out pretty well and really are showing us, and this is hot off the press Ben, that, that I don’t think we’ve said it yet, is that we get about a 10% reduction in average blood sugar. [00:41:00] From one dose. So you can have that one dose with your meal of the day and reduce the immediate impact of glucose.  But that one dose will also give you a 10% reduction in glucose across the board day on day. And we carried out a pretty big trial, 120 subjects over in India at the end of last year. Looking at the effects of pep control across a pretty carbohydrate heavy diet. You know, we wanted it in challenging conditions.

And so we’re pretty confident with this data that looks good. And really what it’s doing is changing the GI impact of your food. So you can have more choice, you can be less exclusive. And to put that in perspective, if we were to look at Metformin, a common drug used to treat. Type two diabetes bt, or an early metabolic syndrome, it might reduce your average daily blood sugar by 25%.

Pretty significant. And obviously if you are healthy and you’re not pre-diabetic, that’s pretty dangerous. You can get some very low hypoglycemic episodes. [00:42:00] So a 10% shift is a nicely and a nice, safe bracket, but it’s high enough to make quite an impact. When we look at the effects of the glycosides, the other, sort of the sulfonylureas, those drugs again that are used to treat type two diabetes, they normally make a sort of one to three milli mo difference in blood sugar, and we’re pretty comparable to those.

So a pretty effective ingredient from once a day that can have an in important effect on lowering that blood sugar, but also giving you more choice in the diet. One of the things I guess that everyone gets excited about is GLP one. And one of the things about DP four, if you inhibit that enzyme, you elevate GLP one, and so therefore you get an indirect effect, but also you get a feeling of fullness, which is a win-win.  Now, obviously, we’ll never get the same effect as a semaglutide. A natural ingredient. You know, it’s incredibly heavily modified that the normal half-life of GLP one is about an hour. [00:43:00] Whereas with semi glutamate, it’s, they’ve managed to get it out to a week, which is pretty impressive, right? So, you know, we’re not gonna get that sort of level of performance, but certainly an elevation of GLP one reduces hunger, increases that feeling of society, so gives us a good room for building off.

Dr. Weitz: We think metformin works through its action on the microbiome. Do these peptides also work through the microbiome?

Dr. Franklyn-Miller: Not specifically. They’re very much DPPP4 and Glute4 focused one of and there’s

Dr. Weitz: glute four and DPP four drugs already on the market right

Dr. Franklyn-Miller: there. There are absolutely, and they’ve certainly gone out of fashion now with the GLP one agonists.  And you know, as you alluded to earlier, you know, as those patterns. Fall off. There are much less attractive target and there are much more attractive targets that can be on and off site. And that’s just the way pharma works. Right. You know, neuro is about. It’s about access. It’s [00:44:00] about legacy ingredients really that will form a part of food.  And one of the reasons that Dr. Nora Kdi founded neuro tasks was she saw the lack of innovation in food. And part of it is the return on investment. You know, it’s to develop a new ingredient is risky. The chances of success are low. And. The rewards are relatively modest because these ingredients ultimately have to be cheap to be incorporated.  If it’s in your bagel or it’s within your past or your noodle as well as being a supplement it can’t be incredibly expensive. And so that’s one of the challenges here is that we want to be able to create ingredients that aren’t astronomically expensive. That can be accessed in multiple different ways.  But of course the first to market companies, the ones that have fast moving SKUs and have developed a educated audience are the ones to first take,

Dr. Weitz: right? And then of course if it has a positive effect on blood [00:45:00] glucose potentially it may have a anti-cancer effect as well.

Dr. Franklyn-Miller: Absolutely. And I think, you know, the, one of the exciting angles we have there is we launched last year. It’s a soft launch is Pep Protect Again, it’s a skin topical peptide. It works via a totally unique mechanism of action. There’s a skin receptor called Panex in one. And what happens when sunlight UVB hits the panex in one channel, it opens and releases a TP which then triggers sun damage on the skin.  And we looked within Marine Micro adi, and within that space there is a. A peptide which protects sun damage in marine microalgae, and rather amazingly, it has the same effect in humans. And so that peptide blocks the panex in one channel and stops that a TP release within U-V-A-U-V-V-U-V-C.

Sunlight and I think we’ve not yet looked, but that [00:46:00] could really be one of our most exciting advances. By being able to block that panex in one channel we need to look and certainly we’re working with some pretty big global universities on. The possibility for it to prevent the development of benign pigments into melanoma and what we can do in skin cancer prevention.  So certainly there’s the, whilst we might have looked there initially for its beauty effect there’s a much more potentially impactful effect there as cancer prevention.

Dr. Weitz: That’s great. This is all very exciting.

Dr. Franklyn-Miller: Absolutely. As I say, it’s an embarrassment of riches on where to look. And and I think, you know, focus is one of our big challenges.  You know, we have so many peptides that, that come through magnify our AI platform that, that really, we’re really trying to pick the ones with the most impact first. That can benefit more people.

Dr. Weitz: It’s interesting, we talk a lot about AI and its benefits and this is really only possible through ai.

Dr. Franklyn-Miller: Absolutely because as I say, you know, it would take us tens and tens of years [00:47:00] to find the combinations of peptides that both survive, but also have a positive impact. And we’d be lost in this preclinical work for the next three or four years alone, looking at one peptide, let alone the bulk. Right.

Dr. Weitz: Great. So there’s been a fascinating talk. Any final thoughts you wanna leave our listeners and viewers and and where should they look to find out about getting ahold of these peptides? I.

Dr. Franklyn-Miller: Absolutely Ben. I think, you know, look, we are gonna produce two new ingredients a year. We’re focused completely on those NCD categories.  You know, gut is very high on our list. Blood lipids is very high on our list. You can imagine along with inflammation. And so, look out for pep control later in the year. And certainly designs for health have been very, quick to market with a lot of these peptides. They have an inside track on what’s coming next.

Cool. In that medical practitioner channel our end goal is food. And you’ll see quite an exciting [00:48:00] launch probably early 26 in an everyday staple where neuro peptides are emerging as a first health promoting ingredient in something. We all eat almost every day. Which is desperately exciting.

Dr. Weitz: So this is what we call a functional food.

Dr. Franklyn-Miller: Absolutely right. And you know, in many respects the Japanese and the Koreans have been doing this for years in terms of functional foods. And it’s really exciting to see this sort of head west and become accepted as truly food is medicine. You know, we often talk about restrictions being food is medicine, but the for the first opportunity to really incorporate food is medicine as a new ingredient with clinical trial evidence showing its benefit incorporated in is incredibly exciting.  Nuritas.com is where all of our latest information will be. And and absolutely. And Ben I’ll look out to, I get some samples of PeptiSleep your way.

Dr. Weitz: That sounds great. I appreciate that.

Dr. Franklyn-Miller: Absolutely.

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Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast.  For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcast or Spotify and give us a five star readings and review. As you may know, I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition and want to prevent chronic problems and wanna promote longevity, please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111 and we can set you up for a consultation for functional medicine and I will talk to everybody next week.

Dr. Eric Fete discusses How Muscle Influences Aging, Performance and Longevity with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

In this episode of the Rational Wellness Podcast, host Dr. Ben Weitz converses with Dr. Eric Fete, an osteopathic physician and founder of Primex, on the topic of muscle health’s impact on aging, performance, and longevity. Dr. Fete discusses the role of muscle as an endocrine organ, its anti-inflammatory effects, and the significance of muscle for metabolic health. The conversation also touches on hormone testing and optimization, the benefits of peptides, and effective strategies for promoting longevity. Dr. Fete emphasizes the importance of natural health practices over synthetic drugs and surgery, and offers practical advice on maintaining muscle mass, managing hormones, and enhancing overall wellness.
00:00 Introduction to the Rational Wellness Podcast
00:26 The Importance of Muscle Health with Dr. Eric Fete
01:49 Muscle as an Endocrine Organ
02:37 Metabolic Benefits of Muscle
04:18 Maintaining Muscle Mass as You Age
06:05 Strength Training and Nutrition
08:13 Hormone Testing and Optimization
10:18 The Role of Testosterone and Other Hormones
15:13 Environmental and Lifestyle Factors
23:09 Testosterone Therapy Options
25:25 Transitioning Away from Pellets
26:02 Exploring Oral Testosterone Formulations
26:35 Introduction to Peptides
27:37 Popular Peptides and Their Benefits
29:47 Peptides for Gut Health
31:40 Peptides for Testosterone and Libido
33:33 Managing Testosterone Side Effects
35:29 Testosterone and Prostate Health
37:18 Testosterone and Cardiovascular Health
38:08 Lifestyle Strategies for Longevity
40:04 Supplements for Longevity
45:46 Final Thoughts and Contact Information
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Dr. Eric Fete is an Osteopathic Physician and the founder of PrimeX, a company focused on preventive health, age management, and peak performance. His expertise includes Hormone therapy, Functional Medicine, nutrition, and peptides aimed at improving overall wellness and the prevention of disease. He is a strong advocate for natural health practices over synthetic drugs and surgery. He is certified in Age Management Medicine, Advanced Bio Identical Hormone Replacement Therapy, and Medical Peptide Therapy and is a member of the Seeds Scientific Research and Performance Institute (SSRP). His website is DrEricPrimeX.com

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

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Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com.  Thanks for joining me, and let’s jump into the podcast.

Hello, rational Wellness podcasters. Our topic for today is how Muscle health influences aging, performance, and longevity with Dr. Eric Fete. Dr. Eric Fete is a osteopathic physician founder of Primex, a company focused on preventative health, age management, and peak performance.  His expertise includes hormone therapy, functional medicine. Nutrition and Peptides aiming at improving overall wellness and the prevention of disease. He’s a strong advocate for natural health practices over synthetic drugs and surgery, and he’s certified in Age Management medicine, advanced bioidentical hormone replacement therapy and medical peptide therapy, and he’s a member of the Seeds Scientific Research and Performance Institute, Dr. Fete. Thank you so much for joining us.

Dr. Fete: Hey, thank you, sir. Appreciate you having me on. Very grateful, love listening to your podcast and looking to have some fun and hopefully provide some value to your listeners.

Dr. Weitz: Sounds good. So why don’t you tell us why muscle is so important for longevity, which is for sure something I strongly believe in.

Dr. Fete: Yeah, definitely with your background, if you could definitely speak to that for sure. Um, yeah, so basically I feel it’s often neglected. I think people are starting to come around to the fact of muscle is actually an endocrine organ. I think in the last number of years we’ve thought of fat that way.  We always thought it’s fat is just blah, but it’s actually an endocrine organ as well. Secretes a lot of what we call cytokines or adipokines that actually have an influence on other parts of her body. And muscle is the same way. So in that regard, muscle’s almost, you know, the skin’s probably the largest, but you know, the mar muscle is actually one of the largest endocrine organs in the body.  So, you know, traditionally people think of muscle as, oh, it’s just, you know, I. It’s just for looks, you know, showing off your, your, your guns and whatnot. And, and that one look good in a bathing suit, but it’s actually a lot more than that. So healthy muscle tissues is above and beyond. What’s, what’s more important.  So it’s just not just the muscle itself, how much, but the functionality of it and most people are aware of. You know, obviously movements and being able to perform your activities of daily living, et cetera, of course. But, um, lot, a lot of people are also aware, of course, that it improves, you know, insulin resistance improves your glucose sensitivity by upgrading upregulating those receptors to handle blood sugar.

This has been fairly known, especially obviously as you know, in the bodybuilding space, et cetera. To do what’s called nutrient partitioning to help. So that’s why so many these, you know, the body bills can eat so much, right? You know, they’re, they’re partitioning their, their fuel, they eat into their muscles instead of their fat.

[00:03:00] Um, but muscle also has, you know, an uh, uh, anti-inflammatory effect and one of the newer things, you know, and the number that’s probably been around for some time, but they secrete also, uh, cytokines with or are called mykines. And these mykines have a lot of effects on the body as well. Which have a lot of health benefits and, you know, age management benefits in terms of helping the body to stay strong and young.

And these mild kinds affect every part of the body. They affect the brain, the bones, the liver, the intestines. Um, they have all these funky names, right? You know, um, you know, of course people have heard of like, like Irisin and interleukin six. Uh, they can affect BDNF, which is a brain drive neurotropic factor in the brain.

Um, you know, it’s all these other little, they have all these names, but basically they perform all these health benefits in the body. And that’s why we think that. Everybody knows how good exercise is, right? Why it’s so good for you, but this is one of the reasons, the hidden reasons why. ’cause when you exert yourself, when you perform.

You know, muscular activity, obviously you’re improving your, your nutrient capacity like we were just talking about, but also these secretes, these myokines and these mykines have these, these endocrine like effects, [00:04:00] almost like hormone like effects on the body to do all the things that we’ve known exercise can do.

We know that exercise can reduce inflammation, improve brain health, make your bones stronger, improve your digestion, all these other things. And this might be one of the ways why, kind of like. They’re like little signaling molecules, so not a lot of people talking about muscle as an organ of longevity, uh, above and beyond just aesthetics.  So I, I, that’s kind of why I took it upon myself to kind of do phrase, what I call muscle medicines, can try to get people aware of the, the health benefits of maintaining muscle mass and we can talk about, you know, sarcopenia and, and that as well. But that’s, that’s the big focus.

Dr. Weitz: Yeah, you mentioned the metabolic advantages of having muscle, and so if everybody’s not familiar, one of the important benefits of having good muscle is that the muscle cells.  Take in blood glucose to use for energy, and that helps manage your blood sugar levels and that reduces your risk of diabetes and helps reduce insulin levels. So muscle is very important for [00:05:00] metabolic health and that of course is a big factor in, uh, brain health and hormonal health, et cetera.

Dr. Fete: Yeah, I mean, we all know how bad, you know, what an epidemic insulin resistance diabetes is.  What is it like over 50% of the population is at least insulin resistant. So it’s a huge problem. So even diabetics can utilize exercise to improve their insulin sensitivity, their blood sugar, which of course is gonna reduce their inflammation, improve their metabolic health, and reduce their risk of cardiovascular disease and all the comorbidities.  So anybody can do it and um, you know, you don’t have to. You know, spend, I always tell you don’t have to spend hours in the gym. You have just a 15 minute workout. You can reap the benefits of it. So, um, but we wanna build muscle and burn the fat because as we get older, unfortunately we get sarcopenia, which is the loss of muscle as we age, and then we get.

Fat. We gain fat and it’s the opposite. So we wanna kind of flip the, flip the switch. We wanna burn off that fat bill at that muscle as much as we can while we’re at any age. But certainly the younger you start, the better. So when we get older, we’re not able, we’re not weak and fat and thin. ’cause that’s, that’s not healthy for many reasons we’ll talk about.

Dr. Weitz:  So what are some of the most important things to do and mistakes to avoid as you get older to maintaining muscle?

Dr. Fete: Yeah, so I think, you know, most guys, it’s a little bit of an easier conversation. Most guys are familiar with strength training. So number one of course is strength training, some type of resistance exercise.  I mean, cardio is great, it’s fantastic. Um, but it’s not gonna maintain that muscle mass. You definitely have to lift heavy things, right? And it doesn’t have to be, you don’t have to be slamming big deadlifts in the gym. You could do kettlebells, you could do bands, uh, even, even something like, you know, pils or power yoga is something to work.  Those muscle body weight exercises are great. So the biggest thing is strength training. And number two is adequate protein intake. So. Most guys are pretty easy to talk. My, my, I always have sometimes have to sway my female clients about this. ’cause a lot of women still have in their minds those myths, right?

They’re like, oh my gosh, I don’t want to put on muscle, I don’t want to get big. Right. You know, so I’m like, I have to explain that it’s not gonna happen. Right? The most important thing is strength training. Number two is nutrition, adequate protein, and adequate. There’s a whole, that’s a whole conversation of itself.  But the biggest mistake I see is not getting enough protein and not eating a whole food-based diet. You know, avoiding the junk, eating the real food. Um, sleep and recovery are massively important because, you know, you could be training, you could be working out, but if you’re only sleeping five hours a night, or you’re waking up, toss and turn, um, you’re not gonna, you’re not gonna build muscle, at least not very effectively.  So you have to sleep and then you have to recover. You know, stress management is, is big. And you probably see this too. So many of my clients are just, they’re stressed, even though they don’t quote unquote, feel stressed. It’s definitely affecting them. They’re. They have what we call sympathetic dominance, or just excessive cortisol, excessive stress, and it’s wearing ’em down.

They’re, they’re fatigued, they’re having cravings, they’re not sleeping. Sex life is off. So, got, you know, I’m a big, uh, I’m a big superhero. I like superheroes. I’ve always been into superheroes. So like, everybody knows Superman, the big red s right? So I call it the double S on the chest. So sleeping stress is like my, my two like kryptonite, things to attack, right?

So gotta get those down. And then I, obviously, I do a lot of hormone optimization too. So as, as a lot of my clientele are in their, you know, as a. Definitely in forties, fifties and up, you know, we have to monitor hormones ’cause if, uh, there’s a hormone deficiency, that can definitely, uh, lead to some sarcopenia, loss of muscle.  So sometimes that’s a missing [00:08:00] piece. And, uh, whether it’s a nutrient deficiency, uh, or a toxin or maybe some gut inflammation, or quite commonly a hormone deficiency that needs to be addressed as well. So those are, and there’s some other things we can talk about. Those are like the big ones. I see the, the biggest thing to move the needle.

Dr. Weitz: So let’s go into the discussion about hormones and we’re gonna focus mainly on male hormones in this discussion. ’cause those are the hormones that are more related to muscle, correct? Yep. So, um, before we get into the use of testosterone as a supplement. What are some, well, to begin with? How do we test for hormones and what things you look at?

Dr. Fete: Yeah, great question. And, and before we, before I forget too, estrogen, estradiol is very important for, has, uh, some anabolic effect as well as does growth hormone, uh, and some of the other hormones as well. Thyroid, they’re all important, but most people think of testosterone, right? And, uh. A lot of the benefits of testosterone come from its metabolites, specifically like Estrodiol and DHT or dihydrotestosterone has a massive anabolic effect too.  So [00:09:00] for me, when it comes down to testing, I mean, number one is, as with anything, I always look at symptoms, right? Because that’s the most important thing. Whether it’s looking at thyroid health or testosterone or estrogen, what do they have symptoms of? A deficiency. That’s the most important thing. ’cause I, you know, you wanna treat.

The patient, right? Not, not worry about the numbers, but the numbers do come into play. And so I will do a, a serum blood test on, on my patients. I’m concerned about a deficiency is the best, the best way to do it, um, to kind of look at the numbers, so it doesn’t really matter when or what time of day. I mean, classically, you’ll read about getting it done first thing in the morning.

Um, but you know, there is a, a waxing and waning, a circadian rhythm of hormones. So as long as you know when they did it, you can kind of correlate that. Um, but basically a serum blood test is gonna give you the best, best test of all your hormones. Um, there’s things you can look at from metabolites of them.  Things like the Dutch test and salivary salivary testing. They’re good for metabolites, but the, the serum testing is gonna give you the best overall picture of what’s in their blood. Now, it doesn’t necessarily tell what’s in their cells, and I see this a lot. So someone, for example, thyroid’s a good, a good example, they have their [00:10:00] numbers in their screen are normal.  But they still have all the symptoms. Well, they’ve got thyroid in their blood, but it’s just not getting into the cell, so we have to figure out why it’s not getting into the cell. Right. So there’s, they’re still clinically hypothyroid, but even though they’re quote unquote normal on paper, so I see this a lot.

Dr. Weitz: So, okay, so what numbers do you like to look at? So you measure testosterone total and free,

Dr. Fete: correct?

Dr. Weitz: Um, DHEA. You measure estradiol and progesterone.

Dr. Fete: Yeah, my women, I’ll, I’ll measure those as well. Um, what about within. Yeah, I mean you can check in men and, and I do, it’s includes this part of my panel, I’ll look at it as well.  Um, but testosterone, the biggest thing is making sure you get both, like you mentioned, the total and the free. And then you look at the DHG as well to kinda look at those downstream metabolites of testosterone. Right? And the other one that sometimes gets forgotten about is SHBG or sex hormone binding globulin.

That’s important, right? Um, you know, you read and you probably, you know, familiar like from decades ago in the bodybuilding forms are everybody’s talking about, oh my gosh, you gotta. Lower your [00:11:00] SHBG ’cause it’s binding up all that free testosterone. Right? Well that’s kind of a, I mean, yes and no, and it’s kind of false because it actually, when the testosterone is bound to that SHBG, but it still has an effect, it still binds to the receptor and has an uh, a hormonal effect, which is positive.

So, and a lot of studies are indicating that they’ll higher your SHBG, the reduced, you have a reduced risk of cancer, cardiovascular disease, and other things. So you don’t wanna lower it. It’s better to be high. And now can it lower your free testosterone? Yeah. But like I said, it still has an effect. But that being said, you still want both of them optimal.

So my men, you know, the typical range is somewhere, usually anywhere. And they’re all gonna be different from lab to lab, but anywhere from 300 to a thousand, give or take. Um, and again, most of my guys, you want them to be at the, at least the midpoint or upper. But again, that’s where symptoms questionnaire comes in because every guy’s different as you, as you know.

So, um, one guy may be at three 50 or you know, 400 or so and feel great. Yeah, everything’s great, you know, he feels wonderful. Great sex drive, good energy. He’s working out hard. Another guy at four 50 may feel like total crap. Uh, and that’s a lot has to do with epigenetics. Uh, how their [00:12:00] metabolism, their SHP jet levels, and a lot has to do with genetics, right?

They have this something called a, a CAG repeat, or a CAG, repeat on their genetic code. And depending if it’s short or long, that’ll d tell ’em, determine if they need a higher testosterone level or lower testosterone. There’s no real easy way to test for that. So it’s just really, again, coming down to symptoms.

That’s why, you know, a lot of guys look for that number. You know, it’s, you know, I dunno if it’s like a, I joke with my ma, my men, about this, right? I don’t think it’s just a guy thing. We’re stuck on sports. It’s like, what’s the score, man? Everybody’s like, what’s my number, doc? I’m like, why do you feel, because I don’t really feel, let’s talk about this.

’cause you know, if you tell ’em the number first, then they’re gonna tell you. What they want, what you want to hear kind of thing. Right? You know, so it’s kind of a game we play, but, um, so everybody’s different. But in general, you want to be at least the midpoint or at least the upper third, you know? So most guys start feeling better.  Again, this is arbitrary numbers, you know, 700, 600 to a thousand, but again, everybody’s different.

Dr. Weitz: And then sometimes you have men where the total testosterone is pretty good, but the free is low. So what do you do there?

Dr. Fete: Yeah, and they’re both important. Um, and again, it comes down to symptoms, right? You wanna [00:13:00] optimize both of them and they may, na may need treatment.  If their total is high and they’re free, they’re not getting enough free. ’cause the free is very powerful, has, even though it’s only, you know, one to 3% of the total testosterone, it still has a powerful effect. Now, on the flip side, sometimes it’s the other way around, right? Some guys will have a low total and a higher free, and.  What people don’t, what? What sometimes gets missed is this is a metabolic marker. And why is the free high? It might be high because your SHBG is low. Um, so there’s less to bind it up. And why is SHBG low? Well, commonly because of insulin resistance and it’s not picked up their, in their blood sugar is high.

Maybe their insulin’s okay, but maybe their helo A1C is up, maybe their triglycerides are up, maybe their HDL HDLs down a little bit and their SBGs down. Those are early. Those are like the canaries in the coal mine. Those are early warning signs of Vincent insulin resistance. Attending, you know, pre-diabetes and metabolic risks.  So it’s, that gets missed a lot. Um, so that can sometimes clue me in right away that we need to work on your insulin resistance, even though they don’t have the classic signs. If we nip it early, we can turn that ship around pretty quickly.

Dr. Weitz: So one of the reasons for low free could be insulin resistance.  What are some of the other reasons?

Dr. Fete: Yeah, I mean, medication reactions of course can affect any lab value. So any medications they may be taking, um, there’s, that’s a common one. Um, but the biggest one is, yeah, insulin resistance. You know, if they’re getting a fatty liver, um, they’re becoming pre-diabetic.  They have excessive inflammation in their body going on. Anything that’s could affect the liver, you know, any toxification pathways to inflammation, um, you know, crappy diet. All these things can affect it. But those, of course, we’re looking for all those things. But the biggest one, of course is insulin resistance.

Dr. Weitz: And and, and sometimes SHBG can be a factor too. You were saying it’s not a factor that often.

Dr. Fete: Right. Yeah. And the SH BG is kind of like, uh, kind of the warning sign, right? If it’s, if it’s low, and that could be because of insulin resistance or some other metabolic abnormal. If it’s high, it’s probably okay.  Probably nothing to be worried about. And unless, of course they’re taking a medication, like a lot of women are on birth control pills or estradiol that can raise your SHBG, but like I said, that, that’s not necessarily a bad thing. 

Dr. Weitz:  But yeah can’t stress raise your SHBG?

Dr. Fete: I’ve never seen that too much.  Really? Okay. Yeah. I imagine anything’s possible, right? But I’ve never seen that directly myself. Okay. Yeah. But stress can, stress can definitely adversely affect all your other hormones. It can crush your testosterone, estrogen, your thyroid, for sure.

Dr. Weitz: What about endocrine disrupting substances?

Dr. Fete: Big time?  Yeah, absolutely. Those are huge. As you know, we live in a very toxic world, right. You know, there’s phthalates and plastics, and we’re bombarded by. You know, EMF and blue light 24 7. We’re sitting in a, in a room with air conditioning and who knows what’s, you know, if there’s mold in the carpet and there’s crap in the food and glyphosate in our water, it’s like we’re bombarded 24-7.  So it’s an uphill battle to live healthy and, uh, toxin free, but it, it can be done.

Dr. Weitz: You ever test for toxins?

Dr. Fete: I do sometimes. Yeah. Um, sometimes I’ll test for toxins. A lot of people will have like, uh, have had some like mold exposure. I have to test for mycotoxins. Um, I’m sure you see this, but I see a lot of gut issues.  Everybody’s got gut issues. 

Dr. Weitz: Yeah. I see a lot of gut issues. Absolutely. Yeah.

Dr. Fete: It’s, you know, for those things we were just talking about, you know, it’s a, it’s rampant, you [00:16:00] know, so, um, gut issues and SIBO and, you know, long haul COVID, actually I’ve been, you know, a lot of people have gut issues from that COVID Really?

And the, yeah, the shots messed up a lot of people’s guts and it’s still lingering, so, yeah. Do you see that a lot too? Yeah, absolutely. I think that kind of gets missed sometimes. A lot of people are so focused on like the lungs and all these other things, but like we’ve, a lot of the studies are showing that these, you know, these, uh, spike proteins and all this stuff kind of hits the gut really hard and cause a lot of long-term damage and inflammation and sets things up for, for future badness.

Dr. Weitz: Yeah, during COVID, we were actually testing, um, COVID, uh, in, in the stool. Yeah. Diagnostic solutions had a COVID test that they could pick it up in the stools, which is an example of the fact that it was having a profound effect on the gut. Definitely nasty stuff, man. For sure.

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Dr. Weitz:  So, um, what about estradiol levels?  What do you like to see in men and is there a level that’s too low or too high? What, what do you like to see?

Dr. Fete: Yeah, there’s, that’s a great question, Ben. There’s a lot of myths about estradiol. A lot of people still talk about again, like, oh, you know, the, the body, you know, the bottom milk form is like, bro, you gotta get your estrogen low, got high estrogen symptoms.  And a lot of that’s just, it’s just not true. You know, it’s just a lot of it, a lot of myths about that. So, as with everything though, anything can be too high or too low, but in general, most of the time it’s better to be on the higher side. You know, our estradiol levels when we were in, you know, our teens and twenties are probably, you know, 75 to a hundred.  Right. Some studies have shown that. So, um, you know, pushing 50, 60, 70 is totally fine and most guys feel better there. There’s a lot of the benefits of testosterone come from like, like I was telling everybody from DHG and from estradiol. When you look at the studies when they break it down, uh, especially things like sex drive, um, fat burning, you know, body composition, that’s from the estradiol.  The whole myth of estradiol is gonna make you gain weight. Exactly that. It’s actually the opposite. When you do an intervention study, like a baseline study versus an intervention, study’s very, very different. So when you do an intervention and women or men, you optimize their estradiol, they actually have improved body comp, improved sexual, you know, function, improved libido.  Um, so most guys are too low because they’re doing things to try to block estrogen, right? Or, uh, they’re taking an astro or some other stuff and they’re, they’re their estrogens, estradiol are coming in super low, five 10. 20. And that’s just too low, you know, so, and you don’t, you don’t necessarily have to do much for that.  If you optimize their testosterone and get ’em off that stuff, they’re gonna, they’re gonna get to where they need to be. Women’s a different story of course, but, um, we may have to give them estradiol, but, uh, it’s actually better to be the, the mid-range to higher side, you know, for, uh, for [00:20:00] health benefits.

Dr. Weitz: And does progesterone have benefits for men.

Dr. Fete: Yeah, that’s a little more mixed. Um, I know there’s a lot of people who promote that and like give progesterone for men, especially if they can’t do testosterone for some reason. But there’s been a number of studies showing that… 

Dr. Weitz:  Some of the integrative neurologists will sometimes use it for brain trauma.

Dr. Fete: Yep. TBI. Yeah, absolutely. Yeah. So I think it has some benefit there. Some studies have shown it could be inflammatory to the vasculature, so a lot of times it’s, you know, a little, some, some, uh, studies indicate that like, you know, some of the, the groups I belong to, my mentors have said not to use it. So, but you’re right, like Dr.

Mark Gordon, you know, some other people have used it for TBI, like you said, ’cause of the, their neuroprotective benefits. So I think it’s a mixed bag, but I find that I never really have to give it to men, like as a, as a medication, usually by optimizing other hormones, lifestyle, it kind of self-corrects.

Dr. Weitz:  So what about DHEA?

Dr. Fete:  DHEA is a good one too. I sometimes feel like it’s the forgotten stepchild.  Right?  You know, it’s DHEA and Pregnenolone. People forget about these, but  they’re important too. They have a lot of health benefits. It can improve, you know, immune system function, improve insulin sensitivity, fat loss.  You know, again, it has an anti-inflammatory effect as it helps, and it’s been studied in some of the longevity stu studies.  I think it was at the TAME trial. I forget that there’s a couple trials showing like, you know, combination therapy of like DHEA, growth hormone and all these things that can improve longevity.  And it’s a, even though it’s a hormone sold, it’s a supplement. It’s cheap, you know, it’s so, it’s easy. There’s not much side effects. Um, now the tricky part is like with like say younger women, sometimes they’re a little more sensitive, so they sometimes we can’t dose them very high. We have to go either not even do it or really low because they sometimes will get oily skin or maybe some acne breakout. So, but women that are old perimenopause, menopause definitely give it to ’em. And some patients who have like arthritis, lupus, uh, they actually take big doses of it and it helps them tremendously. There’s actually. If the FDA’s actually proven like a, you know, standardized commercial version of DHA, they have a different name for it to, of course, you know, to promote for like, you know, these arthritic conditions.  So I like DHEA. 

Dr. Weitz:  What kind of, what kind of dosage do they use for that? 

Dr. Fete: I. Um, it depends, you know, so like for my women, most of the time I’m doing like 5, 10, 15 milligrams, but men 25 to 50, uh, sometimes higher, but for like arthritic conditions, we’re talking like 50, a hundred, 200 milligrams. So it could be okay.

Dr. Weitz:  Yeah. Interesting. Yeah.

Dr. Fete:  And they like it. They feel good. They, it’s it helps their joint pain. They can function better. It’s kind of interesting. So, and then, uh, pregna alone, same thing, has some benefits for, like short-term memory has a, it’s a neuroprotective, it reduces inflammation in the brain as well.  So also used in traumatic brain injuries. Um, people that have those cognitive issues and things like that. Some people. And feel like they get a little, give a little mental, mental clarity, you know, during the day they like, they like how they feel on it. Yeah. And it’s easy, it’s cheap and it’s not much side effects.  Some people can’t tolerate it, but most people do just fine on it.

Dr. Weitz: Yeah. The Fahy trial, which was really the first trial that showed a reversal of epigenetic aging, used a combination of DHEA, growth hormone, and Metformin.

Dr. Fete: Metformin. Yep. Yep.  Absolutely. So it’s safe, it’s innocuous, and, and you know, if it provides benefit, you know, why not, you know?  Right. And it’s, and it’s sold as a supplement, which is interesting, right? And so it’s pretty cheap, pretty easy to get.

Dr. Weitz: Right? So let’s talk about testosterone. Uh, when do you prescribe testosterone? Which forms do you like? And then how much do you prescribe?

Dr. Fete: Yeah. So for my men, I’d say the majority of them, it’s probably 60 40, 70 30, doing injectable.   I have the other percentage of doing a a cream, like the commercial stuff is, is kind of worthless. It’s too low. But when we use a compounded cream at a high concentration, it works just as well, if not better than the injectables.  I like the cream, um, because it’s more of a physiological response, right?  It, it kind of maintains stay levels throughout the day. Every day we get a normal. Rise and fall throughout the day. So it mimics that. I like to try to mimic our physiologic patterns as much as possible. So when it’s easy, especially when you apply it to the scrotum, it’s absorbed very well. It’s some that converts into DHT, which, which provides more anabolic effect, uh, libido effect, and so on and so forth.  So very, very beneficial in that regard. [00:24:00] Um, but some of my guys just are like. I’m just too busy. I’m not gonna remember to do a cream every day, or I don’t want to do that. I’d just rather do an injectable. I’m like, fine, we’ll do an injectable. And I like that too. They both work, uh, teach, you know, everybody has a different preference sometimes for whatever reason.

One works versus the other, and vice versa. But injectable, I like subcutaneous. It’s easy. Uh, you don’t have to go into the muscle. It’s less painful. Um, you’re not going to, you know, people worry about damaging the muscle, getting some scar tissue, whether that’s, you know, it’s kind of thing. But I, it’s definitely less painful, easier smaller needle.

So, and it’s kind of a depot effect, right? It absorbs a little bit more slowly. And it’s, uh, and it’s easy to manage and most of my guys are doing anywhere from two, three times a week. Some guys are doing like, almost like microdosing every day to kind of kinda like the cream, like a real low dose every day, which again is probably the most physiologic.

But you know, some guys are like, I’m not, I don’t, almost don’t wanna poke myself every day like a couple. So it comes down to practical points too, you know, but that’s how my men are, my women. Pretty similar. I have a number a lot doing injectable. A lot of women like the cream. They, they just don’t wanna mess with the needles and they just like the cream and, uh, same thing.

They can apply it to their [00:25:00] skin or transvaginal application is fantastic. Just like with scroll application, men absorbs so well and it can help with the vaginal mucosa. Helps with sex drive and orga orgasmic function. Uh, helps with, uh, improving the pH uh, and the vaginal tissues. Helps with hot flashes, night sweats, and all the other benefits that they, they get.  So they like that as well.

Dr. Weitz: So we also have pellets and now there’s oral testosterone.

Dr. Fete: Yeah, the pellets are, have been popular. Um, back when I had a brick and mortar clinic, I, I did do pellets for a while. Although towards the end, before I left that practice, we were kind of getting away from that. Some people were kind of not liking it anymore.  It was, you know, a slightly invasive procedure. Um, and it’s really not as physiologic, right? You know, you get that big burst, but then over the levels kind of drop over a period of a month or two, and then they don’t feel well. So, you know, the whole point is to be, you know, optimize everything 24 7. So it’s just not a very good.

Pattern for that, right? You’re getting that more artificial up and down, you know, rollercoaster ride of hormones and a lot of patients just don’t like that. Um, so I kind of got away from, I don’t think that’s the best way, but some people love it, you know, if they love it [00:26:00] and it’s working great, you know, have at it.

Yeah, now they have the oral formulation, which is new like Rex, um, which has been, um, pretty effective. I’ve used it a number of patients and I’ve had pretty good results. Um, you know, especially for the younger guys or maybe they’ve, um, my younger guys, I mean, I don’t recommend testosterone will put ’em on something else, but say they want to go on testosterone or they need testosterone, maybe that might be a jumping point, especially if there’s fertility concerns ’cause.  Some of the studies indicate they still maintain a, a good levels of FSH and lh, maybe some better fertility maintenance compared to testosterone. So thus far I’ve had good results. I haven’t had any issues, complications, and it works pretty well.

Dr. Weitz: So, besides, um, hormones, other signaling molecules include peptides, and I know you like to use peptides.  Why don’t you tell us some of the benefits of peptides, some of your favorite peptides, and.

Dr. Fete: Yeah, for sure. So peptides are, like you said, they’re like signaling molecules. They’re, uh, chains of amino acids, um, that are basically, you know, peptides are physiologic, kinda like quo is our body. We make, we make [00:27:00] peptides.  Like insulin is a peptide, right? And that’s been around discover what, the twenties, right. So I always tell people, they ask what it is. I’m like, it’s natural. Our body has like the GLP ones, like ozempic and things. We make our own GLP one in our, in our intestine. Right? So it’s a natural peptide. Pharmacies, of course can now make them in, you know, higher, higher concentrations for beneficial effects.  

So they’re great molecules because they’re very safe. Um, not much downside or side effects, and they’re natural and they’re easy to administer. So there’s a plethora of effects. And man, gosh, there’s so many. Like we were talking before we started corner, there’s so many peptides. Um, it’s just a question of what you wanna use it for.

Um. Again, as signaling molecules, they have a lot of effects on the body. And uh, I’d say some of the more popular ones are like, um, things like the healing peptides. You know, the BPC 1 57, the Thymosin beta, um, GHK, they have a beneficial effects for repairing tissue, damaged tissue, ligaments, tendons, muscles, bones, gut BPCs, great for gut issues, um, you know.

Uh, people have like inflammatory bowel disease or gut dysbiosis or [00:28:00] SIBO or heartburn acid reflux, very beneficial for that. Um, the growth hormone peptides have, have always been, uh, around for a long time. Very popular as well because similar testosterone, we all start losing growth hormone, you know, heck ’cause they’re always our, you know, thirties, uh, and, and it drops so it can stimulate the bite to make its release.

Its more of its own growth hormone and that natural diurnal pattern we get at night. We normally release growth hormone while we sleep. So it’s a nice way to facilitate your body’s. Pumping it out of our own. We, we, we still have it as we get older. We just don’t release it as well from our, from our, from our pituitary gland.  So it’s a nice one. And also for, you know, a lot of anti quote unquote antigen effects, right? Healing of tissues, repair, deeper sleep, improves slow wave sleep, REM sleep.  And it can help with body composition, right? Main maintenance of muscle mass like we’re talking about at the beginning, but

Dr. Weitz: which peptides you like for growth hormone stimulus.

Dr. Fete: Yeah. So, um, the, probably one of the original ones was Smolin, uh, which is still around F fda, A approved, probably not the most powerful one, but it still has an effect. Some people like it. After that, they came up with, uh, what they call the growth hormone, hormone releasing hormone called [00:29:00] CJC, and then a growth hormone releasing peptide called ipamorelin.

Uh, they’re typically given together, although you can use Ipamorelin by itself. That was a great one. But that’s the one they, they kind of. The fda a back in the fall tried to try to get rid of so that we could still, some pharmacies are still compounding, combined with other nutrients, but it’s a little harder to get.

Now. Tessa Molin is probably the most powerful of them. Uh, it’s the most expensive, but it works really, really well. It’s also FDA a approved, and it’s because it’s been used for. Muscle wasting and visceral adiposity. Very, really good at getting rid of that visceral fat, which is very dangerous. Uh, it was, it was used a lot with HIV patients for sarcopenia, so that’s probably the most powerful one.

Uh, but they all work really, really well and they’re a good one to punch with BPC because BPC Upregulates growth hormone receptors in the body, IGF one receptors. So, um, they’re a great combination product. Um. And we were talking about COVID and gut issues. You know, one of the ones I’ve been using, uh, lately too is called Tite.

I dunno if you’ve used that one or heard that one. But, um, that’s great for the gut. Um, a lot of inflammatory bowel issues and all this, the gut stuff. How do

Dr. Weitz: you, how [00:30:00] do you spell that one?

Dr. Fete: Latti? I think it’s L-A-R-O-Z-I. I have, I have to, I have to like spell it slowly. Okay. Razzo Tide R. Yeah. Okay.  L-A-R-A-Z-O-T-I-D-E. And uh, so what it does is when the gut is inflamed, um, it, the, the lining of this, the intestinal wall, as you know, is very thin. It can be become irritated under inflammation and releases a chemical zonulin, right, which is a marker of inflammation. So, uh, LoRa actually improves ZO levels and reduces that inflammation and it heals those tight junctions.  It kind of brings those tight junctions together and uh, makes them. One again. So we, so you don’t get that leaky gut syndrome and it reduces that, uh, zonulin and reduces the inflammation, helps the v the VI heal themselves and to absorb nutrients and, and keep out the toxins. So that’s kind of a cool one.  So many people having gut issues nowadays. It’s a nice, it’s a nice peptide to use for gut health, and especially when you come by with something like BPC orally. Yeah. And BPC helps with leaky gut as well. Definitely. It’s a great one. And it’s nice because that’s one of the few that’s an [00:31:00] oral version. You know, the injectables typically been used for musculoskeletal issues, but the oral BPC is great for the gut.

Dr. Weitz: Yeah, especially for gut. The oral, uh, BPC is really good. I.

Dr. Fete: And if you get it combined with KPV, which is another anti-inflammatory peptide that has kind of a double whammy effect. So those are kind of the more popular ones. You know, there’s, there’s others too that are helpful for like brain health, uh, reducing inflammation in the brain, um, cognitive function, cognitive health, um, you know, different things like that.  There’s, you know, there’s so many peptides. There’s, I. DEXAs and Human ins and you know, the thymus in family clan for anxiety and, uh, you know, mental clarity. So there’s, there’s so many, but, uh, so it kinda depends on the condition of what you’re, but those are kinda the more popular ones.

Dr. Weitz: So for men who have low testosterone or low libido, who don’t want to take exogenous testosterone, can you use peptides?

Are there other supplements that are beneficial?

Dr. Fete: Yeah, for sure. Um, a lot of studies are showing that, especially if they have a deficient, you know, if they’re starting to drop their growth hormone, as you know, it starts pretty young. There’s been some studies showing we just by [00:32:00] optimizing their growth hormone, maybe with these growth hormone peptides, um, you could stimulate, uh, the gona to increase testosterone production.  ’cause if a two tear is kind of the master master gland, right, you optimize your growth hormone, IGF one in the liver and it affects everything. So by optimizing that a lot, some studies are showing you could. Turn that around just by doing that. Um, interesting. And of course there’s tons of, you know, supplements out there, been around forever, right?

And they’re kind of a questionable benefit and they might be able to help with some people, you know, the toca, ALIS, ALIS, the, you know, all those ashwagandha, so on and so forth. Herbal stuff, maybe some benefit, but if it’s young guy, he’s pre clearly deficient clinically and on a laboratory test, you know, I definitely, especially if they’re.  Younger and they’re below 40. I definitely would steer them away from testosterone because of the effects on their fertility. Um, might wanna do something like HCG or uh, Clomid or en clomophine, which can all stimulate the body to make its own testosterone and maintain fertility. And they all work really, really well.  HCG is a little more. Hard to get. Now it’s a lot more expensive, but it’s still available. Um, but I use a, I’ve used it many times. I’ve used Clomid many [00:33:00] times with great success. Um, and it’s a great way to go. And of course now with the Kaiser Rex, that might be another option. I still would probably start them on one of the other ones first and save Kaiser Rex for if they, if they don’t, if it stops working or you know, they wanna switch it up, at least they know.

Or maybe even just talk to ’em about fertility issues. Maybe have ’em do some sper banking if that’s the case. Just to, just to cover the base. Make sure, ’cause some guys are like. Now I’m never having kids. But you, you, you know, you know how that goes. 10 years later, they change your mind like, oh, I wanna have kids now.  So what can we do? Okay. Well, so there’s ways to, there’s ways to reverse that sometimes, but, uh, it’s easier to avoid in the first place.

Dr. Weitz: Right? So one of the side effects that can occur with taking testosterone is you can see an increase in hematocrit and hemoglobin and red blood cell production. So how do you manage that?

Dr. Fete: You can, yeah. You get what’s called a secondary erythrocytosis, and this is another one of the things that I see all the time online. Everybody still talk. Even the doctors will say, that’s polycythemia and it’s not. It’s a, that’s a polycythemia is a, a blood dis blood issue, a blood dyscrasia where all the blood cells are affected.  The platelets, the white blood [00:34:00] cells are red blood cells, so. The erythrocytosis just from testosterone is just the red blood cells. The white blood cells are normal, platelets are normal, and it’s kind of, and and really the erythrocytosis is normal. A lot of people like it ’cause they have better oxygen carrying capacity, better lung capacity, which is why, you know, live athletes do it.  Right. They can like look at Lance Armstrong. Right. You know? Right, right. Yeah. Course he was, don’t eat paja and all that other stuff too. But, um, but it helps and, and really it’s not as big a deal as people make it out to be. You think it, how many thousands of people live it al to in Denver and Nepal and, you know, Himalayas and all these things, and they’ve got blood counts.

They’re hemoglobin hematocrits are super high and they’re doing just fine. They’re not donating blood, they’re not dropping dead of heart attacks and stroke. They’re, they’re living smokers. Same thing. You know, they’re all okay. Um, so this, it’s kind of a myth that you gotta donate blood and do all this kind of stuff.  And actually some of the newer studies are showing that blood donation, if you do it too much, can actually backfire and actually make some problems. So I don’t really find I have to do that if they, their blood counts do go up too much, a little bit. All we had to do is just adjust it. 

Dr. Weitz:  So what do you consider the highest level of say, hematocrit that you’re comfortable with?

Dr. Fete: I’d say most of my guys are like, you know, high end hemoglobin of 18, 19 hematocrit of, you know, maybe 54, somewhere in that range. I think if you’re there below, you’re fine. Um, and again, I, I don’t think, I’ve never seen a lot of the studies don’t even show anything at that level or even above it really happening, but unless you’re way above it.  But I think that’s kind of my comfort level. It’s, it’s, uh, that’s what the studies have shown. Uh, and again, if they’re creeping up there, I’ll just lower the dose a little bit and they, and they won’t feel any different and their blood counts will come down. They’ll be just fine. It’s the easiest way to deal with it.

Dr. Weitz:  Since, since I mentioned one of the side effects to testosterone, what about some of the worries about testosterone, possibly increasing the risk of prostate issues?

Dr. Fete: Yeah, thank, thank goodness that myth has been put to bed, although it’s gonna take a lot of, to people still talk about that. Um, as fortunately it’s been completely disproven.  Um, no risk of prostate cancer. Increasing is the bottom line. If anything, you’ll have a better outcome and a reduced risk overall. People that have prostate cancer, you know, one in seven men are gonna have [00:36:00] prostate cancer at some point. And the lower your testosterone level, the worse outcome you’re gonna have.

And if you, it’s gonna be more aggressive. So. It’s better to have an optimal testosterone level and you’re gonna have a better outcome even if you have prostate cancer. Um, yeah. I think

Dr. Weitz: one of the reasons why that concern comes out is because men with metastatic prostate cancer are often put on therapy to reduce testosterone.  

Dr. Fete: They do. They do. But um, what’s happening is, uh, it’s still, you know, they still have problems down the road and there’s what’s called the, uh, it’s basically that threshold theory, you know, the, uh, the saturation effect is what it’s called. So once the testosterone gets above 200, 2 50, it doesn’t matter.  You could go way higher and will it grow? Will it feed that cancer? So you get to 200, 2 50. Yeah. But at that point above that, it doesn’t do anything. Um, and those guys, when they go on androgen deprivation therapy, yeah, we’ll help temporarily. But they’re gonna be miserable. They’re gonna get osteoporosis, heart of cardiovascular disease, they’re gonna feel terrible, and they’re gonna die more likely of cardiovascular disease, which is the number one killer of men.

Um, and they’re not, they’re gonna die with their prostate cancer or, you know, not, not [00:37:00] because of it. So, and now a lot of people are actually treating prostate cancer with estradiol and, and treating with testosterone. You look at Dr. Abraham Mayhem, Morgentaler, well known urologist out in Harvard, and he’s putting men on testosterone all the time, and they’re doing fantastic.  So it’s the people are actually using it to treat cancers now, so. That ship is finally turned, but those mist still abound that it’s gonna cause cancer.

Dr. Weitz: And then what about the, uh, alleged, uh, worry about the fact that testosterone could increase cardiovascular risk? I know one thing I’ve seen in some men on testosterone is their HDL levels tend to drop.

Dr. Fete: Yeah, same thing. I, I think that’s kind of been kind of disproven at this point too. I think that there’s no increased risk of anything. And if anything, long term they’re gonna do better because they’re gonna reduce their visceral fat, reduce their inflammation, improve their metabolic markers, um, improve ejection fractions, improve their cardiovascular function.  And a lot of men actually lower their blood pressure, um, now with injectable. Yeah, sometimes in the first year or so, they can get a slight dip in their HDL, but it tends to recover and come back to normal, especially if they’re paying attention to lifestyle, [00:38:00] diet, et cetera. Um, the cream not as much, has to have less, less of an effect on the HL but again, usually it’s more of a temporary thing.

Dr. Weitz: Okay. Um, what, what, what is some of the other strategies for promoting longevity besides, uh, hormones? I.

Dr. Fete: Yeah. So I think, um, I think you and I probably agree, you know, talk a lot about, you know, lifestyle. I think that’s still the biggest mover. Yeah. You know, and everybody wants the quick fix in America, right?  We want that magic pill. But you know, you gotta do the basics. You know, you gotta sleep, you gotta eat right, you gotta exercise and move daily. Uh, and that’s sometimes that’s the hardest thing, right? ’cause it takes work on everybody’s part. But I think that is the most important thing. I’m really big on, uh, natural lifestyle and definitely more on like circadian rhythms, uh, quantum biology aspect.

You look at the science of that and you’re like, you know, getting out and looking at the sun every day, getting your feet in the grass, you know, trying to get outside as much as you can away from the wifi. Get your sun, get the sun on your skin. And constant movement. You look at the long-lived societies, they’re the ones that are constantly moving.

They’re outside all day. They have a sense of community. They’re interacting with other people. They’re not sitting there on their [00:39:00] phones by themselves all day long, right? We’re meant to be outside. We’re meant to be moving. So I really try to encourage as much as possible, and I know it’s, you know, we all work.

We have to do stuff, but we can all take breaks and get out and move. So for me, you know, um, really kind of getting back to our roots. I love to blend. I love to blend the new. With the old, you know, trying to get back to the, that ancestral wisdom, right? Of again, community, getting outside, going for hikes in nature, getting the sun on your skin as much as possible, and moving our body, you know, again, going back to muscle medicine, really, and again, we don’t have to throw heavy weights around, but getting out, lifting things, flipping tires, you know, hiking, just being active, using our bodies, that’s what we’re meant to do.

I think that’s, you know. People kind of forget about that. They kind of think that they can hit the gym hard for an hour and just sit on their butt all day and just, and take a shot and not eat right. And they’re like, no, I’m gonna, I’m gonna make you eat right. I’m gonna make you move. And these are foundational.

You just can’t not do that. You know, the peptides are great, the hormones are great, but they are definitely, you know, I hate to say ancillary, but they’re secondary to the lifestyle aspect. You, you definitely have to do those things first.

Dr. Weitz: Are there any medications or [00:40:00] supplements that you think can move the needle in terms of longevity?

Dr. Fete: Yeah, there’s a lot, you know, and, uh, I think there’s some that have been just, you know, known about and there’s some that are kind of like, you know, on the, on the debate table right now. Right. You know, so, you know, we were talking earlier about like things like Metformin and DHA growth hormone, I think pretty well shown.  Um, you know, the other things a little more controversial, like rapamycin, uh, kind of a big anti-aging molecule has been talked about. And I think there’s, you have to be more careful with that. I think it definitely has some benefits, but it has to be the right person and then it might be at the right time and maybe cycling in and out with a, and I like it with like my, similar to peptides.  I think I rotate things in and out. You know, sometimes I’ll put somebody, do, do

Dr. Weitz: you take rapamycin? Have you taken it? I.

Dr. Fete: I have myself, I’m not taking it right now. I, I did it for maybe a month, uh, and then once or twice a year I did that. But I have not done it since. So I think if you’re older, if you’ve got some other metabolic issues, some inflammatory issues, I think there’s some benefit there.  Maybe short term, maybe rotating in and out of your, your regimen, but I don’t think you should be doing all year round, and especially if you’re younger, I don’t think [00:41:00] there’s any need for that.

Dr. Weitz: Right. So what about any, what about any of the supplements for longevity? You know, some of the more popular ones are NMN and Nicotinomide Riboside, which are NAD precursors, right.

Dr. Fete:  Yes, I mean, some of the foundational ones are still applicable, right? You know, good old vitamin K, optimizing your vitamin D with sun exposure. Um, you know, things like that. You know, magnesium is huge. You know, we’re all deficient. Magnesium and has so many functions in the body.  Urolithin A is a cool substance to optimize mitochondrial health, which has been been discovered of late.  Yeah, and NAD optimization is good too. I think the NR, NMN, they have their role, but sometimes I think they’re overused. And if you’ve got some inflammation or some other, some other process going, your body, you can actually make things worse.  So, may not be the best strategy, but I think this, the precursors, like you said, are probably a safe way to go. But some studies indicate you can even just take niacinamide and still get a lot of beneficial effects and it’s cheaper. Um, and the other one is one MNA, I don’t know if you’re familiar with that one, but that I’m not familiar with that.  What is that? So there’s a supplement called one MNA. So. Part of the whole on the biologic cycle and the biophysiology of, of, uh, NAD production, that’s where these NMRs or NR and NMS come in. It’s the, uh, the salvage pathway, that kind of resynthesis of your nas, right? But one of the byproducts of that is called, so, you know, um.

Is, uh, it goes through this process, but this one, MNA, is a pro, is a, a derivative of that. And again, you wanna balance, right? We all want, you can’t take too much of a supplement or too little. So by any, by taking N-R-N-M-N you can do that, but sometimes you might be forcing that pathway to do more than what it should.  So one MNA actually kind of has, its almost like a. Like an adrenal adaptogen, right? If it’s low, it brings it up. If it’s high, it brings it down. So it kind of makes the body balance itself out so you don’t have any excessive, uh, metabolites. So it’s a nice way, and it’ll boost your own. It’ll raise your NAD on its own and keep it balanced in a natural way.  So it’s a, it’s a newer one. Uh, and I, if, if somebody’s got some issues, uh, with their, you [00:43:00] know, uh, concerns about cardiovascular health, inflammation, I think that’s a good one. Uh, instead of the, or the NSNs and nrs, you know, but. If people are doing pretty well, metabolically lab’s normal, it’s, it’s not a bad supplement to take either.

Dr. Weitz: Right. Uh, Omega-3 is always beneficial. 

Dr. Fete: Yeah. Omega threes for sure. Um, you know, and then, um. ’cause we need those for our cell membranes. Uh, plasm mogens have been discovered. Dr. Good. Now, I dunno if you’re familiar with his work or not, but, uh, he’s got some interesting products called, you know, we lose, there’s a, uh, you know, part of our cell membrane is these plasm mogen, and we lose those as we age as well.  Um, so Plasm Mogen deficiency is similar to omega threes. It’s part of that makes the, the, the linings of all our cells and our tissues, especially around our nerves. Um, so that’s another interesting, um, I, I’ve heard about ’em. I haven’t tried ’em though. Yeah. So those are some other, some cutting, some newer kind of things too.  So I think, yeah, I think of the basics of the ones we talked about. You know, keep it simple. There’s a million supplements you could take. Right. You know? Yeah. There’s, [00:44:00] you can go overboard, I think. But I think most people, yeah. 

Dr. Weitz: We even now have plant peptides.

Dr. Fete: Right, right. 

Dr. Weitz:  There’s one called Peptide Strong that I’ve been using on some of the patients.  Yep. Seems to help a little bit.

Dr. Fete: I’ve been using that one as well. That’s an interesting product, Peptistrong. Uh, I think I, I think it has some good data behind it. Um, you know, for Atropin, there’s all these cool things for muscle health. I’ve been using my, you know, some since, uh, occasionally myself.  But yeah, so it’s kind of, it’ll be interesting to see what happens over the next year with all these new products and combinations and, uh, different, different, I think people are starting to catch on to peptides and. Um, like you said, plant molecules, different things like that. So a lot of cool stuff that, that can be done for sure.  But I think start with the basics and kind of build from there. And, and like supplements, peptides again, rotate things in and out. You don’t, you could take 30 supplements a day. I don’t know if that’s necessarily a good thing. Maybe do something for a few months and rotate and do something different.  That’s kind of what I try to do with myself and my patients, otherwise you go crazy taking all these things.

Dr. Weitz: Yeah. I take, I take about 30 supplements twice a day. Uh, what, what’s your favorite book on longevity?

Dr. Fete: Ooh, on longevity. That’s a good one.

Dr. Weitz:  I mean there’s a lot that have been written. We got Peter Atia, we got Mark Hyman. We have, you know, so many people have written books on longevity.

Dr. Fete: I know There’s a good one.  There’s a lot of good ones. Jack Cruz had an interesting book. It’s not really about longevity, but his book, his, I don’t know if you read any of his stuff, his pretty, I haven’t, um, you know, like, is it Peter Attia? Um, Dr. Goods got an interesting, not really about longevity.  Ben Bickman wrote a book about, you know, why we get sick and it has a lot to do with insulin and things like that.  So, you know, my, one of my mentors, Dr. Rouzier has written a book, Dr. Seeds has written some books. I don’t know, there’s so many out there and so many topics is the problem. There’s so many different areas to go, so many rabbit holes to go down, you know?

Dr. Weitz: Yeah. Alright, great. How about you? Um, uh, how, how about final thoughts, uh, and how, what are you, what, what is your contact information?

Dr. Fete: Yeah. No, I appreciate you having me on. I think the biggest thing is just, you know, try to [00:46:00] keep, you know, for me, I try to keep things simple. It’s easy with information overload nowadays and everybody’s googling everything. I think it’s, it’s easy to go down, like we said, so many rabbit holes. I think just really trying to focus on the basics and I want people to kind of remember, like I said, remember the roots saying, kind of get back to.  Our body’s natural rhythms. You know, I am, like I said, try to get outside, embrace nature, you know, embrace community. Uh, communicate with people face to face. You know, lift heavy things, move every day. You know, get your sleep, eat real food. You know, it doesn’t have to, you don’t have to go on a diet, just eat food if it has a label box bag, or can probably shouldn’t eat it, right?

Um, we all have to live a little bit. We all have to cheat. You know, I, everybody knows I like my chocolate, my bourbon, so, you know, we gotta cheat a little bit, but at the same time, try to, you know, eat, eat well most of the time. And then. And then work with a, and please. I always tell people like work with a, you know, a clinician who knows what they’re doing.

I see a lot of people just doing stuff on their own, buying everything online and the black market. And so you have to be really careful. You don’t know what you’re getting. So work with someone, uh, a good, uh, you know, clinician who knows what they’re doing, who’s trained, and who can guide them. Again, not that we know everything, but we can definitely guide them along the way and I want them to take, you know, to take adv, take control of their own health, be their own advocate, right. You know, do double check everything, but work with the, work with multiple docs, clinicians, et cetera. And, uh, so they, so they get some coaching along the way, and I’m happy. 

Dr. Weitz:  Do you recommend physicians who’ve been trained by A4M or IFM or certain, is there a way for somebody to know when they find somebody who’s good?

Dr. Fete: Yeah, I think as someone who’s been certified by a well-known, reputable organization, you know, like, you know, guys like you, you know, you’re very knowledgeable about all these topics. You’ve, you’ve got all the certifications, you know, you know your stuff and you’ve been trained and certified, done a ton of education.  Um, so those, that organizations you mentioned, you know, especially the IFM is great. I for hormones, I’m a big fan of World Link Medical. Dr. Neil EYs been around for decades. He’s probably one of the, the wizards of the hormone space, um, very different from A four M, but he’s, his is all data science based, so I like World Link Medical, um, peptide societies.

Again, I was with, International Peptides Society and they changed, and Dr. Cs took over SSRP and now the, uh, International Peptide Society is being run by a different group now. Um, and I’ve, I’m familiar with them as well, so, yeah. So, you know, whether it’s, you know. Just someone who knows what they’re talking about, who’s actually spending time with patients has been certified.  Someone like yourself or myself or someone like that, I just don’t want the, uh, internet guru with no medical training. And, and again, they’re well-meaning a lot of ’em know their stuff. Right, right. Um, but you just have to be careful, that’s all. So I just want people to get their best help. 

Dr. Weitz:  So how can people contact you?

Dr. Fete: Yeah, so Dr. Eric primex.com is my, is my company, uh, my website.  I’ve got a ton of free stuff on there in my YouTube channel, Dr. Eric Primex. I’ve got tons of free content, free videos, free eBooks on my website and, 

Dr. Weitz:  And what’s the exact website?

Dr. Fete: So Dr. Eric Primax, so D-R-E-R-I-C-P-R-I-M-E-X.com.

Dr. Weitz: Cool.

Dr. Fete: Great.  And, check us out on social media. Again, I’m posting stuff every day, a lot of free videos, trainings, you know, all kind of stuff. I just like to help people and teach and, and talk. I could, I love talking shop, so if I can, uh, you know. Share or help anybody, just let me know. Happy to help.

Dr. Weitz:  Sounds good. Thank you so much, Dr. Fete.

Dr. Fete: Thank you, sir. Appreciate you being on.

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Dr. Weitz:  Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would very much appreciate it if you could go to Apple Podcast or Spotify and give us a five star ratings and review.  As you may know, I continue to accept a limited number of new patients per month for functional medicine. If you would like help overcoming a gut or other chronic health condition, and want to prevent chronic problems, and want to promote longevity. Please call my Santa Monica Weitz Sports chiropractic and nutrition office at 310-395-3111 and we can set you up for a consultation for functional medicine, and I will talk to everybody next week.