Dr. Sarah Ballantyne discusses Nutrient Density with Dr. Ben Weitz.

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Podcast Highlights

1:40  Nutrivore marks a departure for Dr. Ballantyne from the Paleo diet that she previously endorsed as the Paleo Mom, to a more diverse nutritional approach focused on increasing the nutrient density of the diet.

4:45  Food myths.  Chapter 10 of Nutrivore busts many of the myths around food.  Dr. Ballantyne argues that animal foods are not bad for us and she discusses some of the myths related to food quality, olive oil, and organic foods. She argues against the idea that we should avoid eating legumes and grains because of them containing lectins, phytates, and oxalates, which is the argument in paleo circles why we should not eat whole grains or legumes.  Legumes are among the most nutrient dense foods, including being one of the best sources of folate, are mineral rich, and contain lots of fiber.

17:42  Nutrient density score.  Most peoples’ diets fall short of supplying us with the daily values of all the essential nutrients.  And the RDA should really be thought of as the minimum rather than as the optimal levels.  Dr. Ballantyne has developed this system that includes 33 nutrients in the calculation weighed equally, compared to the daily value, and considering the calric content of the food.

 

 



Dr. Sarah Ballantyne was previously known as the PaleoMom and is the best selling author of five books, including her new book, Nutrivore: The Radical New Science for Getting the Nutrients You Need from the Food You EatIn this book, Sarah creates educational resources to help people improve their day-to-day diet and lifestyle choices, empowered and informed by the most current evidence-based scientific research. With Nutrivore, Dr. Sarah has created a positive and inclusive approach to dietary guidance, based in science and devoid of dogma, using nutrient density and sufficiency as its basic principles: Nourishment, not judgment. Her new website is Nutrivore.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz: Hi this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com. Thanks for joining me and let’s jump into the podcast. Hello, Rational Wellness Podcasters.

I’m excited today that we’ll be speaking with Dr. Sarah Ballantyne about her new best selling book, Nutrivore. Nutrivore’s subtitle is the radical new science for getting the nutrients you need from the food you eat.  In this book, Dr. Sarah creates educational resources to help people improve their day to day diet and lifestyle choices, empowered and informed by the most current evidence based scientific research. With [00:01:00] Nutrivore, Dr. Sarah has created a positive and inclusive approach to dietary guidance based in science.  And this is the Rational Wellness podcast, so we love science and devoid of dogma, using nutrient density and sufficiency as its basic principles. Nourishment, not judgment. While there’s a lot of great valuable information in this book, one thing that I found particularly helpful was the Valuable Vitamins Cheat Sheet, which we can refer to.  Dr. Ballantyne, thank you so much for joining us.

Dr. Ballantyne: Oh, thank you so much for having me.

Dr. Weitz: You say Nutrivore in your book is not a diet, however, you were previously known as the Paleo Mom, so in this book, your description of a healthy diet in this book sounds more like a Mediterranean diet, so, it sounds like you changed your [00:02:00] approach, did you have to file divorce papers from the paleo community?

Dr. Ballantyne: I’m, I’m pretty sure it’s still enough through legal action that I’m not allowed to say anything. No, in all seriousness, you know, I think, my transition from Paleo to Nutrivore has been a very iterative process. I can’t say that there was one moment where I went, Oh, I think I’m wrong about some things.  I think this entire community is wrong about some things. I think there is a more diverse diet that we can be embracing that actually will be more health promoting, but also, have better coverage in terms of supplying all of the nutrients that our bodies need. It really, the research started, I think it was 2014 or 2015, I started doing, researching for a book on the gut microbiome, that still has not been published, but it was that research of really trying to understand how different foods impact the composition of the bacterial community that lives in our guts. That was the beginning of me going, oh wait a minute, legumes are really phenomenally health promoting. They’re the most nutrient dense, starchy foods. They have vitamins and minerals that, make them very valuable. They’re really great sources of polyphenols, and I don’t think we think of legumes as, being particularly great sources of polyphenols.  And the more that I did this research, the more I really questioned a lot of the dietary dogma that I had bought into.  And as the research and reading the science really, like, opened up my eyes, I started to realize that I had some disordered eating patterns that I had learned through the Paleo community as well.  So I had this personal journey behind the scenes of addressing my own food fears and expanding my own diet as I was undergoing this professional journey right out in the open for everyone to see as I kept going, excuse me, I think, I think maybe we’re wrong about lentils. I think maybe we’re wrong about corn.  I think maybe we’re wrong about oats. And the, the more foods that I, that are not considered paleo, that I really started to, like, change my mind on, the more it became obvious that it was time for me to move on, and, and build something new, and that’s what Nutrivore is.  

Dr. Weitz: So, you have a chapter in, or a section in your book where you talk about the myth of plant toxins, and, you know, one of the big knocks against legumes and lentils, things like that, are that, and this is a argument that paleo advocates often utilize, that lectins, that these foods like legumes contain lectins and phytates and what are called anti-nutrients or plant toxins and these are one of the main reasons why we want to avoid grains and beans.

Dr. Ballantyne: Yeah, so I actually this is, there was a huge conversation behind the scenes with my editor and the team at Simon Schuster about this chapter. So chapter 10 is a myth busting chapter and it kind of has something for everybody in there because it also talks about, whether or not, right, the myths about animal foods being bad for us, which is not true.  There’s a lot of seafood myths that I bust, a lot of myths about food quality, talking about, you know, olive oil and, organic foods as well.  It was really important to me to include a section on plant toxins, because that was the world that I used to, to, those were the circles I used to be in. And I had sort of learned that way of thinking from very prominent scientists names that we’re all familiar with if, if we’ve heard about Lectins and Phytates and Oxalates.

Dr. Weitz:  We might call this the anti-Gundry section.

Dr. Ballantyne: That could be. And as you dig into the science, I mean there’s, there’s a couple of different layers here. So the first layer is that yes, like sometimes the isolated compound in a food, like in, in a lab, it, in, when scientists are validating these compounds, they’re looking at them for potential use in pharmaceutical industries, typically where these scientific studies come from.  And I used to do this type of research. So like, I’m very, very familiar with how these experiments are designed and the different types of techniques that are used. So you take this, this compound that’s isolated from something. And you, first of all, you put it on some cells, and you see like, what do those cells do?  Does it change the proteins those cells are making, right? Like, that’s a really interesting way to understand that compound. Does it have use in a pharmaceutical industry somehow? And then the next kind of step you do to understand what this compound does is you, use it in animal models. So for example, there are some specific, plant toxins [00:07:00] that in animal models of colitis, when you administer just that one compound, you get increased inflammation.  That sounds really scary. That is not, that scientific study is not there to tell us to not eat the whole food. It’s there to help understand whether or not there’s pharmaceutical applications for that one specific compound in the food. And so we need to be understanding those studies within that bigger picture of how does the whole food, because a food is thousands of different chemical compounds, you know, maybe dozens of different nutrients. How does the whole food affect our entire biology?  Because every food will have something that you could isolate and concentrate and put in some, you know, high doses in an animal and go, okay, here’s a negative impact to one biological system. That is actually where a lot of pharmaceutical discovery has, has come from. A lot of cancer drugs come from exactly that process, [00:08:00] but that doesn’t help us understand the whole food.

And so my, my realization of this sort of logical fallacy of like, just because a food has a compound in it that is harmful to one biological system or one specific circumstance, we can’t judge the whole food based on that compound. And that was one of my main, um you know, uncomfortable realizations that I had been thinking about nutritional sciences in this way that is incorrect. And that really drove me to go back to the research and go, okay, so now let’s actually look at studies showing, like looking at whole legumes and not just looking at phytohemagglutinin as a, as an isolated compound. Let’s see how, in animal models, in humans, in intervention studies, where you give a group of humans and you have them eat more legumes.  Let’s look at these studies. And what you see is. the fiber types, the polyphenols, the very high legumes are the the most nutrient dense starchy foods on [00:09:00] average. They’re very rich in vitamins including folate which is one of the most common nutrient shortfalls in the standard American diet. So legumes tend to be some of our best food sources of folate.  Very very mineral rich. You start to see that the that all of the benefit we’re getting from those nutrients, the way that that fiber impacts the gut microbiome, all of that constellation of beneficial effects that we’re getting from eating the whole food completely suppress any potential negative impact from that one compound that in isolation is not great for us.

We’re not eating that compound in isolation, we’re eating the whole legume. And so that is a major sort of difference in how I have changed my view of research. Another big thing that really shifted for me over the last seven or eight years is putting more value in meta analyses. Now, a scientist will always say, right, that the most rigorous scientific [00:10:00] evidence is meta analyses, systematic reviews, umbrella reviews, right?  Like these are the studies, that pool together data for many, many, many studies. So they have a bigger data set. So they have more statistical power, and they incorporate a step of evaluating studies for bias. And so they, they actually have a step for evaluating a study’s quality before they incorporate the data into their giant data set.  And then they typically include a, now let’s also look at all of these, animal model studies, cell culture studies that help explain why this is the average effect we’re seeing. And that is another change that I’ve really made over the last, you know, several years in how I am understanding food is instead of looking at that one study that used phytohemagglutinin in an animal model of colitis, right, and showed increased inflammation.  I’m looking at the systematic reviews that look at all of the different [00:11:00] intervention studies where they take a group of people and have them eat more legumes and then measure various health outcomes, look at it, reducing risk of cardiovascular disease, type 2 diabetes, how it can cause weight loss in people with overweight or obesity how it can reduce risk of certain types of cancer, like looking at that big, big picture in these huge studies that are pooling together data from 20, 30, 300 different studies.  So they have really, really high statistical power. So it’s also a more rigorous approach, and one that really values scientific consensus. And so I included that in Chapter 10 because, I know my followers have kind of watched this whole journey, right? They’ve, they’ve seen all the little bits and pieces as I start to piece this together and really question a lot of the diet dogma that I held to be true.  But it’s also there for the, for the people who are not following that closely to help them understand my transition to a permissive dietary [00:12:00] structure where we can make room in a healthy diet for any food.

Dr. Weitz: That’s great. I generally agree with your overall dietary approach. However, when it comes to the research, it continues to be problematic.  And even if you’re looking at meta analyses, unfortunately, most of the dietary studies are not randomized controlled trials where they give people certain foods and they’re basically just asking people to fill out these food frequency questionnaires, which are so inaccurate. And that makes it difficult, I think, to talk about the real science when it comes to food.  You can’t just take a group of people and just give them, make sure they’re eating legumes, you know.

Dr. Ballantyne: So let’s drill down on that because I think, you know, your point of large perspective studies is really important. Like, I think that is a really important thing to sort of explain to your listeners here.  So perspective studies, or they can be retrospective too, [00:13:00] but these are the studies where we take, I don’t know, 20,000 people and we follow them for 10 years, right? Things like, these are things like, the NHANES study, Framingham, right? There’s these huge, huge cohort studies.

Dr. Weitz: Right, but none of these are control trials where you’re actually giving them food.  So you really have no idea what they’re eating. And then they’re filling out these food frequency questionnaires, sometimes asking them, what did you eat in the last month?  Sometimes in the last year?  And, you know, the recall is so sketchy.

Dr. Ballantyne: Absolutely. So different cohorts have different levels of, sort of trust in their diet recalls.  So for example, the NHANES cohort, their diet recalls are what did you eat over the last two days? And they take that as various snapshots over time. So that is considered a dataset that is much more reliable in terms of, like, actually reflecting what people eat, but also, Our memory is fallible.  We do not want to admit to eating certain things when we’re [00:14:00] being given a survey. And all of those studies are correlative, right? So they tell us that there may be an association, but we have no way of knowing from those types of studies if that association is causative. Did that group of people have lower cardiovascular disease risk because they eat fewer legumes or more legumes, or is it because of this constellation of factors, because that’s the other thing that we see in these types of studies is something called healthy user bias.

So this is where somebody who is eating more plant foods, less, I mean this is a big problem in all of the studies showing that red meat is problematic. It’s a big problem. It’s like a classic example of healthy user bias because red meat has been demonized for so long that people who don’t eat very much red meat tend to eat more fruits and vegetables, they tend to be more active, they tend to also have higher socioeconomic status, so they have social determinants of health working in their favor.  They tend to be female, who also we just get less cardiovascular disease.  And so it’s really hard when you have a lot of different things stacking in these correlative studies to be able to separate out, okay, but how much of this is that these people are eating more legumes? And how much of it is all of the other things that go along with that person who eats more legumes?

And that is, This is absolutely a challenge in nutritional sciences research, and one of the reasons why I never only rely on prospective studies in my interpretation of nutritional sciences. So fortunately for us, we are getting more randomized control. They’re not blind, because you can’t blind somebody from the diet they’re eating, typically.  There’s a few studies where they’ll be like, here’s a muffin and you don’t know if that’s the muffin that has the extra fiber in it or not, right? There are some studies that they can figure out blind, but overall diet studies, we can’t, but we are getting more studies where they take one group of people and say, keep doing what you’re doing, and they take another group of people and they have them work with a dietitian, they work with a, you know, work with a health coach, and they have a dietary structure for [00:16:00] them to follow.

And we’re getting more and more of those studies that we can then go, okay, so we have the intervention study that reinforces what we see in this big observational one that can’t establish causality. And then we can also look at The nutrient difference in, in what these people are eating and look at what we know about how those nutrients impact these biological systems and make a strong case for that being the causal mechanism here as well.  So it is very much about, yes, I absolutely agree that not putting too much weight into an observational study because it cannot establish causality. But taking that as our indication that here’s something to drill down further on understanding healthy user bias and, and how that impacts statistical analyses, but also then we can start layering on, other, other evidence.  And I think we do have a Fortunately, a growing body of intervention clinical trials, randomized but not blind, as well as animal [00:17:00] models that can help to drill down on the biochemical mechanisms behind the benefits.

Dr. Weitz: And let’s get back to the scientific information that you’re adding to our body of knowledge, which is the nutrient density of foods.  So tell us why higher nutrient density is so important and then how do we measure it?

Dr. Ballantyne: Yeah. So, I think that the background piece of information here is that most people’s diets fall short of actually supplying us with even the daily values of all of the essential nutrients, which, 

Dr. Weitz:  Which we know are very, very under, you know, very limited and most people would benefit from having more than the RDA.

Dr. Ballantyne: Absolutely correct. So, so we’re falling short of the RDA. Okay. And there’s some indication that the RDAs are still maybe not optimized, right? Like, they really need to be thought of as a minimum for most nutrients. I think they’re probably in the range for some. And [00:18:00] so there’s four essential nutrients for which 90 percent of Americans are not hitting the daily value, ever.  There’s ten essential nutrients for which half don’t of Americans are more or not hitting the daily value. But even when you, there’s a lot of different studies that will analyze diets that either look at meal plans from, you know, cookbooks or whatever, or they’ll look at people following that diet and look at what they’re actually eating.  And they’ll analyze the diets for nutrients and show that even people who are following diets anticipating that those are healthier ways to eat. Uh, each diet has a collection of nutrients that are a lot harder to get. And so there is a proportion of people who are not meeting the daily values of those nutrients.  And, I mean, government dietary guidelines aren’t off the hook here either. Even the dietary guidelines for Americans has a collection of about five nutrients that people aren’t getting enough of even if you follow the guidelines perfectly. So this is kind of a thing that is across dietary guidelines.

Dr. Weitz: Not to mention that there’s thousands of phytonutrients for which we have no guidelines at all and nobody has aren’t even calculated.

Dr. Ballantyne: Ew, I’m so glad you brought that up. I mean, we have, there’s like 10 ish thousand phytonutrients of which we really understand a few hundred. We know the more of them we consume, the healthier we are on average.  We know the biochemical mechanisms, there are very strong antioxidants, they tend to be anti inflammatory. Different phytonutrients localize in different areas of the body, they interact with different pathways, so they have a wide range of different benefits. So, we want. to be consuming a wide range of phytonutrients.  And there’s no daily value for phytonutrients. There’s probably enough data to actually establish one for polyphenols, but that hasn’t been done because we don’t get daily values for non essential nutrients. But I think you and I are on the same page that maybe phytonutrients could be labeled as essential just because they’re so important.

So we are, we’re in a situation where even people who are really intentional about their [00:20:00] food choices because We don’t learn this, right? We don’t learn in school, but also in dietary templates. When you are picking up a diet book at the store, you’re typically learning about what to not eat or how to measure the things that you eat.  You’re typically not learning about nutrients and what they do in the body and which foods contain what nutrients and how to choose foods from different groups so that you’re getting the full range of nutrients that your body needs. And that is what I am building with Nutrivore. And so that includes identifying nutrient dense foods and focusing on them because we’re trying to fill that gap.

So typically, our intake of these nutrients is high enough that we don’t have a disease of malnutrition, right? We don’t have scurvy. We’re getting enough vitamin C to not have scurvy, but we’re still falling short of hitting our daily value and vitamin C is definitely an example of a nutrient for which we Getting a lot higher than the daily value has been shown to have a lot of benefits for, for various situations.  [00:21:00] So, we’re in that weird ray of like, okay, it’s not so low that we’re like, I’m really, really sick, but not getting enough vitamin C is increasing risk of mental health challenges, increasing risk of cardiovascular disease. It’s having a negative impact on our health. So the best way to fill not just that vitamin C gap, but all of the different gaps that we have is identifying nutrient dense foods and being intentional about adding them to our diets.  So that is again, one of the tools that I am creating in my book, A Nutrivore.

Dr. Weitz: I’m curious as to how you come up with this, nutrient density score, for example, are all nutrients equal weighted? Are some more important than others, you know, how, how much is considered a good amount?

Dr. Ballantyne: Oh, I, that’s okay.  I’m going to nerd out about nutrient density calculation math with you. I think you, we’ve got [00:22:00] another three hours, I hope. So, I created something called the Nutrivore score, which is a measurement of nutrient density, which is scientifically defined. This is the consensus definition as total nutrients per calorie.  The definition of nutrient density, like it, Nutrient density calculations have an interesting history. So a nutrient dense food, that term was first coined in the 70s and it was defined as any food with a substantial amount of nutrients per serving. Substantial was not like specified any more than that.  You’re like, what does that mean? And so, I was someone who was alive in the 70s, 80s, and 90s. I remember labels and how that was like the beginning of like the health aura and the like healthification of labels but not the product, right? That led to a lot of challenges. And what ended up happening in the 70s, 80s and 90s was the demonization of foods as bad because they had high [00:23:00] fat content, like avocados, nuts and seeds, right?  These foods that we now recognize are really like important heart healthy fats. Those foods got demonized for having high fat content. But a sugary fruit punch could say a good source of vitamin C on the label if it had 10 percent of the daily value per glass. And so in the early 2000s, that definition was updated to significant amounts of nutrients per calorie.  Because we were in a situation, we’re still at a situation, where there’s no shortage of calories in the food supply, but there is a shortage of nutrients in the food supply. So we need to understand how to get more nutrients per calorie, not more servings of foods. And at the same time, scientists are working on different nutrient density scores.  So there’s a few dozen of them that have been created over time, none of which have been adopted by any institute or agency. My initial intention when I was first building the Nutrivore website and working on the the early foundational content.  In preparation for writing the book was I’m going to go through all this research and figure out which one’s the [00:24:00] closest to being ready for prime time, which one is almost there.  And I’m just going to use whichever is the best one in the science. I spent three months reading every single nutrient profiling paper out there. And I kept hitting, well, why are you guys doing that? I kept hitting these moments where I was like, That makes no sense. So, couple of the challenges, and you identified a few right in the question.  So, one of the biggest like, like pitfalls that I see happening in nutrient profiling right now is scientists are trying to figure out which nutrients to include in the calculation so that the score at the end aligns with the healthy eating index, which is a measurement of how well someone’s diet follows the USDA dietary guidelines for Americans.

Uh, it’s kind of like retrofitting the score for the guidelines that already exist. I think that’s the opposite of the right way to go about it. I think we should be figuring out how to understand the food and then seeing what that tells us about maybe some edits to the next day. The guidelines are [00:25:00] updated every five years.  It would not be a big deal to edit them again and go, hey, now we know these foods are more nutritionally important, right? That, that’s, there’s, that should be something that can happen. And then there’s this idea of like penalizing foods for containing things like added sugars or sodium or saturated fats or cholesterol.  And then there’s this idea of, like weighting certain nutrients. That’s all kind of happening right now in the scientific literature. So like the Food Compass is sort of well known because it keeps making the news for having such a high score for Lucky Charms cereal. It is not ready for primetime either, although I think it’s probably the most interesting out of the ones that are in development right now.

Dr. Weitz: We have to look at who’s funding all this food science.

Dr. Ballantyne: They’re weighting food attributes, they call them, in a way that is a very like plant based diet lean. And the fact of the matter is you don’t need to weigh certain nutrients more [00:26:00] heavily than others to get to the end of plants have lots of nutrients per calorie.  Like that’s, that’s an easy conclusion. All of these different scores come up with that result. That’s not something you need to put in the math, but that’s what a lot of the direct to consumer, right? That’s what Furman’s ANDI score does as well. It doesn’t include nutrients that are mostly found in animal foods but it includes a lot of nutrients that are only found in plant foods.  And you end up with a system that makes animal foods look terrible and plant foods look great. So with that being, my starting place, like that’s okay. This is, this is the field of science. What that, this is what I have to work with here. I, I, it was a really obvious like algorithmic choice for me.

So the Nutrivore score is algorithmically identical to something called the Nutri Rich Foods Index. So it’s simply a sum of amount of nutrient divided by daily value of nutrient, and then that sum is divided by the energy density of the food. There’s no weighting certain [00:27:00] nutrients more heavily than others.  I think you end up in a situation where you, you bias foods when you start doing that. And also, you could take the approach of, I’m going to weight the nutrients that people are more likely to be deficient in. more in this, like, I’m gonna, like, let’s say it’s like folate, vitamin E, vitamin A, vitamin D. I’m going to give those more weight.  Magnesium, vitamin D. Magnesium, vitamin C. But, you know what happens when you do that and you create an entire system on that, is you overcompensate, right? So people start choosing those foods because they have these higher scores and now they’re missing out on the nutrients that are not given as much weight in the calculation.

So that just felt like that the future proofing of the score is to not actually give these nutrients more weight, but to include as many different nutrients as I have enough data that makes sense to. So the Nutrivore score includes 33 nutrients in the calculation and weight them all equally and make sure that I have representation in these [00:28:00] nutrients of nutrients that are inherent to plant foods, that those are the only source, but also nutrients that are inherent to animal foods, that that’s the only source, so that we’re not automatically putting in a plant based diet bias into the score, and then do all of the math blind, and then just see what it tells me.

And so the NutriScore doesn’t, like, all the nutrients are weighted the same. There’s no, it’s really too complex of a system to be able to do corrections for competitive binding or nutrient synergy because it has to do with everything you eat at a meal and not just what’s in one food, like, as soon as you put salad dressing on your salad, you’re going to absorb more vitamin K and beta carotene, it’s way, it’s, it’s way too complex, and it doesn’t really tell us about the food.  So it’s just a very simple calculation. And it’s the context of like how much is nutrient is versus how much we need. It’s the daily value. Thank you. Yes, the daily values might be an underestimate, but in terms of the math, that doesn’t really matter, because what it is doing is it is basically saying, [00:29:00] this thing we need 100, 100 milligrams of so 200 milligrams in this food is amazing, right?

That’s so great. This thing we need 10 nanograms of, I don’t think there’s anything that’s measured in nanograms, 10 micrograms of, okay, so we’re gonna, we’re gonna, you know, basically it’s, it’s a way of correcting for how much we need. So it doesn’t really matter that they’re, they might be a little bit off.

It’s ballpark is, is good enough in that math. Uh, and then yeah. And then there’s no normalization. There’s no weighing for different food groups, which some of these scores do. They’ll just say, okay, we’ll give the top food in every, in every group. We’ll get a hundred. So then all of a sudden you’re making, you’re making like kale look the same as like whole wheat bread because they’re the tops in their groups, which is, I think also silly.  So it just keeps it very, very simple. It’s a straight up calculation. Yeah. The thing that’s special about it is how much data is in the calculation and that’s why it gives us such a complete picture of the nutrient density of foods.

Dr. Weitz: I make a prediction you’re probably not going to get a huge grant from [00:30:00] Kellogg’s for your program.

Dr. Ballantyne: No, but you know what, a grant would be a grant. Would it be a grant? As long, as long as I can maintain my independence. Yeah, no chance, chances, chances are good. Uh, the Kellogg’s cereal tends, tends not to, even fortified tends, tends not to have Amazing nutrients. 

Dr. Weitz: You know that whole fortification thing, it’s interesting.  There’s an example of where you’re weighting certain nutrients and how we think we’re making people healthier. Just take iodine as an example. So we had all these millions of people suffering from goiter because they had low iodine. And so we add iodine fortification by adding it to the salt and we have this huge decrease in the number of people with goiter.  And we have this huge increase in the number of people with autoimmune thyroid Hashimoto’s. So, you know, it’s being applauded for years now as this great example of how fortification is so beneficial, but [00:31:00] we just traded one disease for another.

Dr. Ballantyne: I mean, potentially, as somebody with Hashimoto’s thyroiditis very, very personal one there.

Dr. Weitz: You can put me in that camp too. 

Dr. Ballantyne: Yeah, I know. It’s like worst initiation ritual ever to get into that club, right? But, but yeah, I think, you know, that’s, so fortification is fascinating to me. Let’s go on this tangent. Because, because, you know, it really has very limited success stories. So even if you, even if you bought into that very simple narrative of we got a 74 percent reduction in, in goiter.  And even if you wanted to say Hashimoto’s thyroiditis is much more complex than iodine excess. And so let’s, let’s not count that as, as like coming off of the success story. I think there’s a lot of nuance here and probably Of course. 

Dr. Weitz: Yeah. I was oversimplifying for sure.

Dr. Ballantyne: And then we’ve got iron fortification, and that has caused, if I remember correctly, it’s like 30 or 40 percent reduction in iron deficiency anemia, [00:32:00] and then folic acid fortification has pretty, like, impressively reduced risk of neural tube defects.  Those are the three success stories of fortification, right? So we’ve got three success stories, we fortify with a lot more nutrients than just those three, right? Like pretty much all the B vitamins except B12 are in a fortification. Okay, well not B7 either. All of the, the, the B vitamins that we were known about in the 40s.  And then we’ve got vitamin D, but not, not in that many. That’s mostly in, dairy products that are geared at kids and not as much in dairy products that are geared as adults. I think it’s, it’s, It’s kind of surprising how little of an effect fortification has had on, well, no effect, on like the really big You know, health conditions that are a major burden on society that can completely take away your quality of life, that have really high morbidity and [00:33:00] mortality rates, right?  Like cardiovascular disease and type 2 diabetes and cancer. You can’t see a signal from fortification reflected in those health outcomes, nor can you from multivitamins. Which is fascinating to me, and it really to me reinforces the importance of getting at least most of our nutrients from whole foods.

Not that I’m anti supplement, there’s definitely a time and a place. Like, I take so much vitamin D to keep my levels normal, right? Like, I’m definitely not anti supplement, but I think that if you think of fortification as a supplement, right? It’s the same forms that are in a multivitamin, generally. It really, you see the value of a food first approach and then, you know, individualized supplementation as a second layer rather than supplementing the entire food supply.

Dr. Weitz: Right. So, since you’ve been calculating the nutrient density of so many foods, tell us about some of the biggest surprises that you’ve discovered, which [00:34:00] you talk about in your book.

Dr. Ballantyne: Yeah, there have been,

Dr. Weitz: by the way, warning, warning, … Sarah is about to bust some of the food myths and functional medicine practitioners are not going to be happy.

Dr. Ballantyne: Yes. Uh, thank you for the, like rolling out the, what is the opposite of the red carpet for the answer to this question. So I think the, there’ve been a lot of surprises now, my take a sort of high level view to this question before I share like the most nutrient dense food, which nobody would have ever guessed in a million years.  I think the best way to use the Nutrivore score is to identify simple swaps or additions in a meal that don’t take away from like your enjoyment of the meal, but will add a lot of nutrition to the meal. So like a really easy example would be like if you’re making a pasta dish, like swapping out regular pasta for whole grain pasta will add some nutrients, but then if you swap that out for like a lentil or chickpea based pasta, so you’re [00:35:00] gonna, you’re gonna double your nutrient density going from like plain whole wheat, you’re going to about quadruple it going up to like a lentil or chickpea based pasta.

And that’s all you did. But then maybe you also identified a simple addition and you added some sliced mushrooms to your sauce or some basil or some garlic. Probably added a lot of flavor to the sauce as well, but then you added a lot of nutrition and Your pasta dish is probably just as great. So, as a practical tool, I think that’s the best way to use the Nutri Force score.  My favorite, like, nerding out surprise moments, are the foods that have reputations for being nutritionally pointless, that get a redemption arc, that through the Nutri Force score calculation, my favorite example of this is iceberg lettuce, which has more nutrients per calorie than celery, or, which we put up on this pedestal.  or Cucumber or Artichoke. It actually has slightly more nutrients per calorie than Sockeye Salmon. 

Dr. Weitz: Does celery juice cure all ails?

Dr. Ballantyne: Waiting for the scientific study to show that one. So far, [00:36:00] so far so far lacking. Although celery does have some really interesting polyphenols, but you’re getting that from celery in any form, it doesn’t have to be juiced.  So that’s my favorite way to use the Nutri Score. Is to kind of say, like, look at the value of iceberg lettuce, look at the value of watermelon or potatoes. Like, foods that people kind of love to dunk on. But there’s also been a lot of, you know, Just like, who, okay, who could have known that the single most nutrient dense food was canned clam liquid?  Like, that is not something, if you had told me, like, here’s, here’s your data set of 8, 000 foods, guess, what, what are you gonna guess? And I would have guessed liver, maybe, Or maybe like a Leafy Green, like Watercress, and Watercress and Liver are both, like, way up there. But the single most nutrient dense food is canned clam liquid.  And here’s how the math works out. Like, here’s, here’s how that happens. I feel like that needs, because I do not want to start a drinking clam juice story. Trend That is not what we’re trying to do here. . I wanna say why we’re run clam

Dr. Weitz: juice in every [00:37:00] grocery store. .

Dr. Ballantyne: I mean, if you are going to incorporate, make sure to go up on totally paper

Dr. Weitz: and clam juice.

Dr. Ballantyne: Clam juice. Empty, empty shelves. Make sure to look for a low sodium option if this is something that you want to incorporate. You don’t have to, though. I think that’s the other liberating thing about the new, the 

Dr. Weitz: What the hell is clam juice anyway?

Dr. Ballantyne: So it is literally the liquid that, like, clams are cooked in.  So, so you can either get it from, like, it is the liquid when you drain a can of clams, or you can buy it separately because it’s used as an ingredient in linguine with clam sauce in clam chowder. It’s used as a cocktail ingredient. So it has some like traditional like food uses as well. But yeah, it is the liquid that clams are cooked in typically pressure cooked in.

Dr. Weitz: So there is some I think you should change the name to clam broth. It’ll sell like crazy.

Dr. Ballantyne: Yes. Clam juice does kind of sound like you squeezed the clams. That’s, I’m pretty sure there’s no squeezing [00:38:00] step. It’s just Heating them in liquid, then doing something really cool with the clams, and then selling the liquid because it has a lot of flavor.  Clam Bisque, I mean, I guess you could think of it as, yeah, but it’s unseasoned. So, there’s a lot of nutrients that are in the clams that ends up, you know, that are water soluble that end up in the liquid. So the reason why canned clam liquid or clam juice is the top most nutrient dense food, and this is true for all of the most nutrient dense foods, it’s very very low energy density.  So when you divide by a very small number, you get a much bigger number. So a food that has a very low energy density So canned clam liquid is five calories per cup. When you have something that’s that low energy density, it doesn’t have to have a ton of nutrition to have high nutrients per calorie.  So remember, nutrient density is nutrients per calorie, not per serving or per hundred grams. So, when you have something that’s super low energy density, doesn’t need to have a ton of nutrition. And canned clam liquid, [00:39:00] has some impressive nutrition. It has 500 percent of the daily value of vitamin B12 in a one cup serving, like, which is just huge.  And it also has some potassium, some other minerals, it’s, you know, it’s got some other B vitamins, it’s got some protein. So it has an impressive amount of nutrition. for that five calories. That’s how the math works out for it to be the top. But is it going to contribute the most, like, nutrients to your diet?

No, that’s going to be a food like the actual clams, right, or oysters, or liver, or those like really nutrient dense leafy greens like kale and watercress and rainbow chard. Those are all the foods that are going to contribute a lot more to your diet. like absolute nutrition, which is why I never recommend only using the NutriVerse score to choose our foods, that we, it’s fascinating, it tells us a lot about a food, but it’s not the only information that we want to be considering when we’re putting together our plates, because then we’re going to end up with a diet where we’re just eating, Clam juice and watercress all day and that’s not going to be [00:40:00] nutritionally beneficial.  But other foods that have that like really low energy density that end up with really high NutriVore scores are not as alarming as clam juice. Like coffee is way up there. You know, it’s, it’s one of the top most nutrient dense foods because it’s packed with polyphenols, actually has some B vitamins as well.  but also one or two calories per cup. A lot of leafy greens make the cut. Same, same thing, right? Not very high nutrient density, but for each calorie, tons of nutrition.

Dr. Weitz: Interesting. You also break the myth about healthy fats and you state in your book, that healthier fats include olive oil.  Avocado oil, which most functional medicine practitioners agree with, and soybean oil, canola oil, corn oil, and sunflower oil, which many in the functional medicine community do not agree with.

Dr. Ballantyne: Yeah, this was [00:41:00] one of I want you to just imagine me coming from a place where I was very anti vegetable oils in the past and really reading in the science and falling down this rabbit hole of scientific studies for a few weeks, because I had such a hard time wrapping my head around this.  So I, I want to, like, like, I want to preface my answer to this question by, yep, I, my inner child had a temper tantrum as I was reading these studies. I had a really hard time. Being open to this research. It was, it was really challenging, and, and it’s because We’ve got such a strong mechanism in place for understanding high omega 6 polyunsaturated fats in relation to omega 3 polyunsaturated fats and how those should be inflammatory, right?

We, we just have such a wealth of scientific evidence showing that, These fats in the cell membrane are used as substrate and what, which one you have will [00:42:00] determine which you know, paracrine and autocrine signaling molecules are made. We know that if omega 6 is there, we get inflammatory signals.

We know if omega 3 is there, we get either anti inflammatory or anti inflammatory. Only mildly inflammatory signals. Like, we have, we have it all mapped out. We know, we know all the biochemical mechanisms. And yet, when you give humans canola oil, or corn oil, or soybean oil, not only does it lower their cardiovascular disease risk factors, like, like, seeing lower serum cholesterol, is only exciting if you also see lower cardiovascular disease risk, which we do.

We see lower all cause mortality, a general indicator of health and longevity. And, what’s fascinating is studies that have actually compared canola oil head to head with olive oil intervention trials have shown They’re both equally as good for cardiovascular disease risk, and they work through different mechanisms, so actually, we would be, we would be best off if we were incorporating [00:43:00] both into our diets, which is mind blowing, because it tells us that there is some regulation of these paracrine and autocrine signaling molecules beyond substrate bioavailability.

but we don’t know what it is. And that is, fascinating. This is definitely a, science has really shifted in the last five years. We’ve got now a really good body of scientific evidence showing benefits to vegetable oils. I still put olive oil on a pedestal. I still think olive oil is, is the king of oils.

You just can’t, you just can’t, like the polyphenols, the triterpenes, it’s got so much good stuff in it. You, you really can’t, I don’t, I don’t think you can beat olive oil, but it shows that these more affordable. oil options are beneficial. Not as good as olive oil, but for somebody on a budget, you know, still beneficial.

And I think what’s, what’s so important in following that science is, again, right, the difference between how we understood it when it was in animal models, [00:44:00] and cell culture models, versus now how we understand it in humans, and the fact that it reveals an important something different in our biochemistry that we still need to understand, but we’ve got these intervention trials that make the result very, very clear.

Dr. Weitz: I just want to apologize to the listeners for this gardener who’s right outside my window who seems like he’s never gonna stop with his lawn blower or whatever it is. So I wanted to push back just a little bit because I do think that a percentage of these studies that have shown that there’s a decreased cardiovascular risk with soybean oil and some of these other polyunsaturated oils is because they’re comparing saturated fat with substituting a soybean oil or something like that and That’s not necessarily substituting an omega 6 versus omega 3 or, you [00:45:00] know, an overall different type of, you know, there aren’t too many studies that, you mentioned one, but there aren’t too many studies that are really comparing olive oil versus soybean oil.  uh, saturated fats versus polyunsaturated fats and the polyunsaturated fats having some benefit potentially.

Dr. Ballantyne: Yes, I, so I think that’s a great point. So I think, the, the broader point is when we switch to something, right, There’s two parts of the equation. There is whether or not the thing we’re now eating, what its health effects are, and what is the thing that we swapped it out for.  Right. So absolutely correct. The studies that show benefits to vegetable oils are the studies that show swapping out butter or margarine for vegetable oils. So swapping out a saturated fat, whether that’s a natural saturated fat or a man made saturated fat, which what fully hydrogenated vegetable oils and margarine are.

For an [00:46:00] unsaturated fat. I still think that’s very fascinating and I still think that it makes a strong case for benefits of vegetable oil, but there are now more, more studies that are comparing vegetables to olive oil. There’s one that I cite in the book that compared If I remember correctly, it compared, olive oil, corn oil, sunflower oil, and I think canola was in there, and it looked at all cause mortality, again, sort of a broad indicator of health and longevity.

And, I think, like, nobody is surprised, it showed olive oil, right, high oleic uh, acid, right, a omega 9, a monounsaturated fatty acid, extremely rigorously shown to reduce cardiovascular disease risk, right? So, it showed olive oil was, was, was the king, was definitely beneficial but then it showed still reductions in all cause mortality from other vegetable oils and increases in all cause mortality from margarine and butter.

So your [00:47:00] zero was not having these things, right? And I think, I think there is a good enough body of scientific literature, for example, showing in humans that we don’t see vegetable oil consumption increasing C reactive protein or TNF Tumor Necrosis Factor Alpha, or Interleukin 6, like these markers of inflammation.

I think there is enough information to say solidly, again, olive oil, avocado oil, I don’t think you could compete with them because those monounsaturated fats are so beneficial. But I think we can take a step back for sure from saying that vegetable oils are problematic. I don’t, science does not support saying that they’re increasing cardiovascular disease risk or that they’re inflammatory.

Dr. Weitz: Just to play devil’s advocate one more time, I hope you don’t mind, is, there was the Minnesota study, which was one of the few dietary studies where they actually had people staying at this mental institution and they were able to control everything they ate so they know accurately what they really ate.  And it turns out that when they [00:48:00] substituted, omega 6 oils for saturated fats, While there was a potential reduction in cardiovascular disease, all cause mortality actually increased in those eating the vegetable oils, and the conclusion seemed to be that there was an increase in cancer, which people attributed to some sort of increase in inflammation.

Dr. Ballantyne: I, I’d be very interested, I’m not super familiar with that study, so I, I don’t. 

Dr. Weitz: Remember the studies in the 60s, and the Minnesota was. Oh, the Minnesota starvation. Published, and they went. It was the Minnesota

Dr. Ballantyne: starvation experiment, was also part of it.

Dr. Weitz: I don’t know. This was like in a mental institution and they hadn’t published it.  And then just like in the last, I don’t know, 10, 15 years, they published it. And so.

Dr. Ballantyne: Yeah. I mean, I I don’t want to, to speculate on the quality of that study, having not, not read it. I, my, my, my little alarm bells go up as soon as you say the data was published 30 or 40 years later, because we don’t actually know what the methodology [00:49:00] was in that case.  The people who probably, We’re taking, right, taking notes on that data may no longer be with us. So I do have little like my little skeptic are dark up, but I don’t want to comment because I’m, I’m not familiar. That’s

Dr. Weitz: okay. Since, since you’re breaking myths, you also said something about olive oil, which I think people need to hear.  I talked to so many people who are like, I won’t cook with olive oil because it’s, it’s going to become rancid. It’s going to be damaged by the heat. Can you explain what the deal is and is it okay to fry my eggs in olive oil?

Dr. Ballantyne: It is absolutely fine to cook with olive oil. They’ve done studies where they sit, they heat olive oil for like 24 hours and measure how much of the fats get oxidized in that time and show olive oil is actually incredibly heat stable.  The higher the quality of olive oil, typically the better, even though it has a lower smoking point. So we do want to be aware of smoking points when we’re cooking with something like olive oil. So can

Dr. Weitz: you explain the difference between smoke point [00:50:00] and is it burning and heat stability? Okay.

Dr. Ballantyne: Yeah. So I’m going to try.  This, this is, I’m going to try. There, we’re getting into some really interesting physics phenomenon here. So, what is making a high quality olive oil have a lower smoke point, which is the temperature at which it will start to smoke is 

Dr. Weitz: And people automatically assume that means that the oil’s getting damaged.

Dr. Ballantyne: Yes, it kind of, so it is sort of. So it doesn’t necessarily mean oxidation of fat, so there’s other things in the olive oil that are starting to burn. So it is some, but it is other compounds, and these are compounds that are taken out in the refinement process in a regular olive oil. That’s why a refined olive oil has a longer shelf life and has a higher smoke point.  So it’s more like these other compounds are there that they can start to burn at a lower temperature and then that can trigger a bit of a downstream [00:51:00] chemical reaction for making some of the fats oxidize. So if you heat an oil to smoke, point. If it’s really smoking, like if I’m in my kitchen, if I overheated the pan, I didn’t realize it, if I’m putting the smoke, if I put the oil in and it smokes a little bit, I’m going to take the pan off the heat, I’m going to throw something in it, food, not water, don’t, don’t, not water, food in it to cool it down real fast, I’m not going to worry about it.  If I throw it in and it is like, smoke detector, like I need to throw on the fan over the range because it is smoking that much, I’m gonna toss that, I’m not gonna, like that is now going to have a lot of oxidized fat in it, and it can happen quite quickly.

Dr. Weitz: Right.

Dr. Ballantyne: So, that being said, If you’re staying below smoke point, which most cooking applications will be like, like olive oil hat, depending on the quality of olive oil, it’s going to have a smoke point in the like 360 to 410 range.

Yeah.

Dr. Weitz: I’ve seen 375, 350. [00:52:00] Yeah.

Dr. Ballantyne: Most like baking is getting to like a hundred and sixty like anything in the oven, right? That your actual functional temperature is not as high Like your surface temperature on the food is not as high as the oven temperature, right? That’s because that’s that’s how cooking works. 

Dr. Weitz: Wait, wait, wait, wait.  I don’t think most people understand that So, so if you bake vegetables in the oven and you put the temperature at 375, the food’s not at 375

Dr. Ballantyne: Not yet. Yeah, it takes, so the food, so think about the heat transfer. Okay. So your food starts off, let’s say at room temperature. Okay. So it’s, it’s, it’s starting off at, I don’t know, 70 degrees.

Dr. Weitz: Right.

Dr. Ballantyne: You rub some oil on it, some, some seasoning, you put that in the oven at 375. Let’s say the smoke point of your oil is 375, right? So you’re right at that that line. You are, until you’re at a point where the food is starting to burn, you are not at a point where that oil is going to be hitting the smoke point because the food [00:53:00] has, it’s like a heat sink, right?  So it’s absorbing the heat, from the rest of the oven, but the temperature of the food, where that oil is, isn’t coming up to the temperature of the oven yet, until, right, until you’re, it’s starting to burn, but in that like, nice phase of like, I’ve got a little browning, a little roasting, it’s very, very delicious, you haven’t hit the smoke point of the oil.

Okay. If you pull the pan out. Things are starting to burn. You pull the pan out and you can see smoke coming from the pan. You overdid it. So typically for me, if I’m roasting vegetables, I actually typically do them at 375, but I’m using an olive oil that’s going to have a smoke point more in the 400 to 410 range.

So like I never, I’m not risking it, by having the oven temperature higher than the smoke point. But like this is why you can bake with olive oil, right? Like baked goods, the internal temperature typically is getting up to 160 is typically where a baked muffin or, you know, a cake or something is, is done.

So most of the time, even on your pan, [00:54:00] The temperatures that you’re cooking with in your pan are probably more likely in the 300 range than in the 400 range. Again, unless you’re overheating the pan, which can happen. So these fats are absolutely fine to cook with. It is the vitamin E and the polyphenols are helping to prevent oxidation, but also just those monounsaturated fats are more heat stable than a lot of other, a lot of other oils.  So absolutely fine to cook with. But if, if you, if you whoopsie, and we all whoopsie, it’s fine. Like that is a normal I’m cooking at home experience, and you’re getting a lot of smoke, off of that oil, I, I would recommend tossing it and starting over.

Dr. Weitz: Okay, so you can cook with olive oil, you can bake with olive oil, but just keep the temperatures down below the smoke point.  So if your olive oil has a smoke point of 400 or 375, you know, then don’t roast at 450, roast at 350 or something like that. And with the pan, if you’re making eggs or something on a pan, just don’t [00:55:00] put it up to the highest heat and just watch to make sure that the oil’s not.

Dr. Ballantyne: Most pans don’t like that either, right?  Like most Most of your pans aren’t even as like, I mostly cook on stainless steel. My stainless steel pans don’t want to be cooked, like heated up on, on maximum heat either, like they’re going to warp. So it’s, it’s good for the oil and good for your cookware.

Dr. Weitz: So does higher nutrient density of your food correlate with better health outcomes and or longevity?

Dr. Ballantyne: Yes, so, what we know is that people who get more, have a more nutritious diet, who have fewer nutrient shortfalls, who are, like, eating more of these nutrient dense foods, eating, right, eating more vegetables, eating more fruit, eating more seafood, like these foods that are very nutrient dense, they have reduced risk of heart disease, all cause mortality, cardiovascular disease, type 2 diabetes, cancer, Alzheimer’s disease, osteoporosis you know, like a list goes on and on and on. Do we have studies looking at people [00:56:00] following Nutrivor yet to be able to say that? Not yet. Not yet. But Nutrivor is very much built on the scientific consensus around the importance of nutrients and the overall eating patterns that are shown in a wealth of studies to support long term human health.

Dr. Weitz: You state in your book that being overweight is not necessarily associated with being unhealthy and that you can be overweight, or obese and still be metabolically healthy. Isn’t it the case that in the U. S. Very few people are actually metabolically healthy. In fact, one study published in 2018 found that only 12 percent of Americans were actually metabolically healthy.

Dr. Ballantyne: Uh, yes. So there’s a little bit of a difference in how, like, how metabolically healthy is defined. So the study that said that only 12 percent of people are metabolically healthy used a like more rigorous definition. There’s been other studies that, you know, basically it’s like how [00:57:00] many health markers have to be normal to be called metabolically healthy and how many are allowed to be abnormal, before we start calling you, metabolically abnormal.  Uh, so it’s like do you say zero markers, one marker, or two markers? And that’s, that’s kind of how it’s searched for hard to compared the actual stats in some of these studies because they’re using a slightly different definition. So, in one study that I quote in the book, it showed that basically about half of overweight people are metabolically healthy.

About a quarter of normal weight people are metabolically abnormal. We can’t directly compare that to the 12 percent study because they’re using a definite, a different definition. So, of like how many of these markers and which markers exactly we’re looking at. So it makes it a little bit tough, tough to, to do a direct comparison there.

I think the, rather than getting like into the weeds of the actual number because of that challenge with how it’s defined in different studies, I think the more important thing is to take that step back and say, look at this number of overweight and obese people. It’s about a third of [00:58:00] obese people, about half of overweight people who you know, have normal blood pressure, normal serum triglycerides, normal CRP, normal fasting insulin and glucose, normal A1c, like, they are the example of people who are not experiencing metabolic health detriment.

And when you, regardless of how you define, like, how rigorously you define metabolically normal versus abnormal, The, the, when you start to striate these populations based on other things other than BMI and you look at, for example, physical activity is, physical activity is the strongest indicator. So people who are physically active regardless of their weight have a vastly higher percent chance of being metabolically healthy and people who are inactive regardless of their weight have a vastly higher chance of having metabolic abnormalities.

Other factors that are influenced. are things like diet quality how much sleep we’re getting, right social determinants of, [00:59:00] of health. Uh, so that’s reflected in things like socioeconomic status and race and ethnicity. So it’s complex. And I think that because, because we have these large population studies showing, you know, 50 percent of overweight people are metabolically healthy.

Again, regardless of these differences and how different studies define it. The, I think the take home from there is these other things like physical activity, like diet quality are where the focus needs to be, right? We also see that most people regain weight when they lose it, right? That weight loss diets are not sustainable.

I’ve gone through this experience myself, having lost substantial amounts of weight three times in my life. Uh, hopefully third time’s the charm. We’ll see. It’s, it’s such a I think anybody who’s gone through it, so I can say from my own personal experience, the science backs this up, but this is my own experience.[01:00:00]

My health has not correlated very much, very well with my weight. So I have had very, very good health at moments in time where I have been heavier. And I have had very, very poor health at moments in time when I have been lighter and vice versa, right? Like, but the correlation is not really, you can’t really, you can’t really line it up.

But I can line up how my health has. related to my stress levels and I can line up how my health is related to my activity levels and my overall average diet quality. And so what I want to do with Mutivore is create that focus on the health habits that somebody who is obese, those are health habits that typically will lead to, to weight loss.

Maybe not for everyone. The great thing is it will lead to health independent of weight loss. So I’m trying to, create something that’s weight inclusive, that is certainly compatible with weight loss goals. You can definitely apply a NutriVer philosophy to [01:01:00] an energy deficit. Like that is absolutely something that you can do.

And actually I would recommend it because the less the gain, the harder it is to get all of the nutrients that we need. So the more that nutrient density focus is actually important. But I don’t want. The benefits of a healthy diet to feel unobtainable for somebody just because they haven’t had success on a weight loss plan in the past.  And by shifting that focus to the things that actually matter for long term health, independent of weight, that’s what I’m hoping to achieve is improving people’s health. And it’ll be, you know, individual whether or not that goes along with weight loss.

Dr. Weitz: Right, and you’re also trying to shift the focus away from all these restrictive diets and, you know, in the functional medicine world we constantly have discussions about, you know, which is the best diet, the vegan, the carnivore, you gotta avoid food BODMAPs, you gotta avoid lectins, Oxalates, Histamines, [01:02:00] on and on and on and people are constantly, oh I don’t know if I should eat that food because it might create oxalate and you know it it just gets kind of crazy end up with uh people on very very restrictive diets and that’s not healthy.

Dr. Ballantyne: I agree completely. And I think it’s not, I mean, there’s two challenges with restrictive diets. First is the fewer foods you eat, the harder it is to actually meet your nutritional needs from those foods. So that is kind of goes against the, the NutriVer philosophy. But the second one is we’ve got psychology research dating back to the nineties showing that restrictive diets lead to disordered eating patterns, emotional eating, weight regain cycles.

It’s, it’s when you define a diet based on the things you’re missing. and that you are depriving yourself of. It doesn’t set us up psychologically to sustain that diet. So on Nutrivore, we really talk about sustainable nutrition. So how do we increase diet quality, but without depriving us of our favorite foods?

Other than for medical reasons, that’s obviously a separate, that’s obviously a separate thing over [01:03:00] there. But how do we intentionally make room for what I call quality of life foods in order to sustain that overall higher quality diet? So that is a large part of the discussion in the first part of the book.

Dr. Weitz: Yeah, I feel like you’re in some ways carrying forward kind of the Part of the philosophy of Dr. Jeffrey Bland, who I used to, every year, go to his lecture he would give. I used to listen to his audiotapes, and when everybody was engaged in all these diet wars, and they still are, of course, he’s always talked about emphasizing the quality of the food and not just, you know, how much fat and how much carbs, and we’ve got to look at the quality, and, and that’s what this is sort of getting to.  Let me, let me ask you one more question and we’ll wrap. You mentioned 12 foundational food families in your book, which are the categories of foods with the most nutrient density. So I thought this would be a good way to kind of sum, sum up this discussion. [01:04:00]

Dr. Ballantyne: Yes, so the 12 foundational food families are all of the foods that have something unique to offer us nutritionally, that have a really like solid foundation of scientific studies showing us health benefits of the nutrients those foods contain.  It doesn’t mean we have to eat all of them. So, for example, one of them is seafood, and if you’re allergic to seafood, or you can’t access it because it’s not affordable to you, like, it’s, it is, none of those foods are a absolute 100 percent must, but they are the foods that help, expedite the goal of getting all of the nutrients our bodies need from the foods we eat, which is our bodies.  the goal of Nutrivore. So they are the foods that make achieving that the easiest. And when we prioritize, I, I lay out serving targets per day or per week, depending on what food we’re talking about of these 12 foundational food families in the book. That adds up to like a third to maybe half of our, of our food intake, depending on, on, on what you’re choosing.

It is a small portion of the overall diet, but when we do that, that gets us most of the way to [01:05:00] achieving our, our nutrition. goals, you know, our daily values of everything across the board. So they are very much about achieving that goal efficiently so that we have the most room for rounding out with whatever other foods we want.  So the 12 foundational food families are, I will just list them vegetables in general, root vegetables, leafy vegetables, cruciferous vegetables, mushrooms, alliums, that’s the onion family, fruit in general, berries and citrus fruit, seafood I already mentioned, legumes, and nuts and seeds.

Dr. Weitz: That’s great. This is just an aside.  I just recently became acquainted with one of the downsides of eating fruits, which is, for some reason, in the last couple of weeks, our house has become inundated with fruit flies.

Dr. Ballantyne: Oh, I have, I have two suggestions for you. Oh, really? Wow. Yes, let’s, great, perfect, perfect question to wrap up on. So, So I will say, you can buy these little, they’re like yellow look at like fruit fly traps or, gnat traps [01:06:00] on Amazon or wherever.  They’re these little pieces of yellow sticky, they’ve got some kind of coating on it that attracts insects. So in my house they’ll also, Find the occasional mosquito that makes its way in. I got rid of fungus gnats on one of my plants from them. And then I was like, what if I put this close to the bananas?  What will that do to the fruit flies? Oh look, it catches them. So that is the lowest, lowest effort one. But the free option is get a like old plastic, like a plastic water bottle, something like that. Stab some holes in the side so that there’s a way in, but the great thing about stabbing it, I use like a metal, like skewer for meat to stab, stab a ring of holes around the outside.

And then I stick, you can either use a string to like put a little bit of banana, it works really well. But a little bit of fruit either on a string that is like then tied with the cap. So it’s dangling down. or you can use like a bamboo skewer or something like that to put it in [01:07:00] so that you’ve got a little bit of fruit towards the top.

So the rotting fruit in there is going to be slightly higher than the holes. And then put like a half inch of water at the bottom with a drop of dish soap. So fruit flies are amazing at getting in. They’re not very good at getting out. They gorge themselves on the fruit and then they drop into the soapy water and drown.  And it is a fun project to do with kids. Definitely, highly recommend. Uh, careful with the stabbing things, because sometimes kids get a little excited by that. And it works, and it works, I definitely, it’s the, it works better than the sticky stuff. But then you do have that. And then when you’re ready, I just put, tape over the holes and throw the whole thing out.

Dr. Weitz: Oh, cool. That’s great. So tell our listeners how they can get a hold of the book and find out more about you, Ann. I’d

Dr. Ballantyne: love to. Thank you. Uh, so the book is called Nutrivore, The Radical New Science for Getting the Nutrients You Need from the Food You Eat. It’s available from just about any online bookseller and lots of local bookstores.  You can also request it at your local library if they don’t already have a copy. My website is neutrovore. com and that’s where like all of the really academic deep dive articles that are like the supporting evidence for everything in the book. Uh, that’s where all of those live and on social media, on TikTok, YouTube, Facebook, Instagram, threads, and Pinterest.  I’m at Dr. Sarah Ballantyne.

Dr. Weitz: That’s great. Thank you so much.

Dr. Ballantyne: Thank you.


Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy. Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a 5 star ratings and review.  If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. Some of the areas I specialize in include helping patients with specific health issues like gut problems. [01:09:00] neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen, and to help you promote longevity.  and take a deeper dive into some of those factors that can lead to chronic diseases along the way. Please call my Santa Monica White Sports Chiropractic and Nutrition office at 310 395 3111 and we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

Dr. Dipti Sagar discusses The Management of Constipation at the Functional Medicine Discussion Group meeting on May 23, 2024 with moderator Dr. Ben Weitz.  

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

8:20  “No organ in the body is so misunderstood, so slandered, and maltreated as the colon.”  “Besides death, constipation is the big fear in hospitals.”  The goal of the presentation is to understand the pathophysiology of constipation, including the diagnosis, the presentation and pattern recognition, management, and the association with the gut microbiome, as well as other illnesses.Constipation occurs in 10 to 20% of the population and about 700,000 individuals present in the ER for constipation every year in the United States.  And 10 billion is spent annually on laxatives.

10:42  Slow transit constipation vs obstructive defecation.  You want to ask your patients two questions related to constipation:  1. How frequently do you have a bowel movement, and 2. Do you have difficulty with evacuation?  If you only have a bowel movement every two or three days or even longer, then this indicates slow transit constipation. If you have difficulty with evacuation, then you have to start thinking about obstructive defecation, the most common form is pelvic dyssynergia. 

12:05  Secondary causes. There are a number of secondary causes of constipation, including diabetes and hypothyroidism, medications including opioids, NSAIDs, anti-cholinergics, calcium channel blockers and diuretics, and iron supplemention. Other secondary causes of constipation include neurological disorders, including Parkinson’s disease, Multiple Sclerosis, and dementia, and myopathic diseases that include scleroderma and amyloidosis, and structural disorders, including colon cancer and strictures.

 



Dr. Dipti Sagar is an Integrative Gastroenterologist and she is presently sharing an office with Dr. Sam Rahbar at LA Integrative GI and Nutrition in Los Angeles, California  (310) 289-8000.  You can find more information at the LAIntegrativeGI.com website.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com. Thanks for joining me and let’s jump into the podcast. Hello everybody I’m Dr. Ben Weitz. Thank you for joining our functional medicine discussion group meeting.  I very much apologize for no food tonight. Unfortunately, Chop’s Eatery, who we ordered the food from, decided to go out of business yesterday.  So, sometimes stuff happens. I hope you’ll consider attending some of our future meetings. Next month we have Dr. Darren Ingalls, who’s going to be speaking about Lyme disease, and that’s going to be June 27th. July 25th, Alan Barrie on Hypothalamus, Pituitary, Adrenal Access. We don’t have a speaker yet for August.  September, we have Dr. Pimentel. I encourage everyone to participate and ask questions, and if you’re not aware, we have a closed Facebook page, the Functional Medicine Discussion Group of Santa Monica, so you can join there and we can continue the discussion. I post a lot of research studies there and have discussions about functional medicine.

I’ll be recording this event, and I’ll be posting it as part of my Rational Wellness Podcast, and you can find that on Apple Podcast, Spotify, YouTube. If you listen to the Rational Wellness Podcast, please go to Apple or Spotify, give me a five star rating, set a review, and our sponsor for this evening is Integrative Therapeutics.  I’m going to ask Steve right here to comment. Tell us about a few integrated products. Thank you, Steve. 


Steve : Thank you. Hello. Thanks for coming. Glad to be here.  I, the topic is constipation, right? Yes. That’s not a huge thing for us. We had a great product called laxative formula.  Unfortunately, we discontinued it. We do have a really nice formula called Motility Activator that, works as a, almost like an adaptogen for the gut. And so whether you tend towards loose stools or constipation, it actually helps with both. It’s a high potency ginger and artichoke extracts.  It’s a great formula. We sell a lot of it. That’s it right now. So maybe Dr. Rahbar will, I’ll listen and learn something tonight. We’ll come up with something new. Also in the back we have some of the, we have a couple new ones. There’s a vitamin D with K. This new, we kind of got into this late, , which is how we kind of roll, but this is a good thing because we’ve, we waited until sort of the, the science was clear on which [00:03:00] nutrients and how much to use.  So it’s a really, really good formula. That’s, it’s a 5, 000 IUs of vitamin D, 180 micrograms of K2, and it’s about half the price of K Force. So if you use K Force, it’s the same formula at about 25 bucks. We also have a brand new Mag threonate that I don’t even have, it’s that new, it came on our website today.  That one is also gonna be similar, it’s a high potency Mag threonate with a low cost. And then we have samples of Cortisol Manager, which you guys all know about and also the new curcumin, which is called Curalieve.  So get those.

Dr. Weitz: And then of course, one of the main causes of constipation is, is Methane SIBO and you guys have the elemental diet. 

Steve : Yeah. So we talked a little bit about the elemental diet. It’s, this is not the place, there’s too much to go into with the elemental diet, but it’s the only Real one out there right now. I guess Mark Pimentel’s come out with one that’s close, [00:04:00] but it’s super high in carbs So if you’re interested somebody already did tonight talk to talk to me about the elemental diet We also have last one.  We have a product called Blue Heron And I’ll just it’s it’s a oldie but a goodie. And the reason it’s called Blue Heron is because Blue Herons poop a lot. So If you happen to want to try that one, it’s something we can talk about too So there you go. Thanks for coming.


 

Dr. Weitz: Thanks, Steve. And so our speaker for tonight is Dr. Dipti Sagar, and she’s a integrative gastroenterologist who works with Dr. Sam Rhabar. And so why don’t you go ahead and introduce yourself, Dipti, and get started. Thank you. 

Dr. Sagar: Can you guys hear me okay? Yeah. Okay, so a very good evening to everyone. This is such an honor presenting here this evening, not only because I get to meet like minded physicians like you all, but because of how profoundly this has affected my life as a physician.  I first got introduced to holistic integrative medicine, then after several years of practice as a gastroenterologist, As a medical director in a big county hospital, doing thousands of endoscopies and coloscopies, and giving PPI to my patients like candies, I realized that a lot of my patients were not getting better.  So that made me look into what we are missing in traditional medicine. So I started to dig deeper and wanted to see some non traditional ways of treating my patients. And then I had my own journey. where I started having GI issues. Yes, a gastroenterologist with heartburn. And very quickly I realized that I could not take those medications that I was prescribing to my patients.  And that really put me [00:06:00] into this path to explore non traditional ways of healing. And I started this two year fellowship with Academy of Integrative, , , , Academy of Holistic and Integrative Medicine, where I really learned a lot, but unfortunately I could not bring those concepts into my previous practice.

But that said, I do believe that when you have an intention, the universe makes it happen for you. Just like we didn’t have a laptop today, but someone just walked in with a laptop. So when you have the intention, it happens. And I guess that’s how Dr. Rebar and me found each other and we started this collaboration together to do our practices together because of similar mindset.  And I’m really so very grateful for that collaboration because it has infused love, passion and life in medicine for me. And I really call this my rebirth as a physician. And to my surprise, my patients were very accepting of this kind of a model where I’m combining traditional medicine with holistic and complementary medicine because I thought I’m going to get so much pushback from my patients.  But instead they looked at me and said, what took you so long? This is what we have been waiting for all along. So really it changed my relationship with my patients as well. So without further ado, because I know I have to condense my 15 to 20 years of experience treating constipation into just 60 minutes, and now I actually have only 55 minutes, so let’s begin.

Dr. Weitz: Well, we have till 8:00 pm.

Dr. Sagar: All right, so I’m going back. Let’s see. There we go. So my collaborators for this presentation is Dr. Rahbar and Dr. Erdman.  So, as a gastroenterologist, I can very well relate to the first statement, which is that no organ in the body is so misunderstood, so slandered, and maltreated as the colon. And as physicians and providers, some of you probably working in a hospital setting, could relate to the second statement, that besides death, constipation is the big fear in hospitals.  So what is the goal of today’s presentation? We are going to understand the pathophysiology of constipation. We are going to learn about diagnosis, management, presentation and pattern recognition, association with gut microbiome, as well as other illnesses.  And we are going to understand the principles of management.  Let’s talk a little bit about the disease burden.  So, it affects about 10-20 percent of the population, and to be honest, it’s very underdiagnosed because a lot of the patients, they don’t even come to physicians for this, and they just think that this is normal, or they just have to live with it.  So this is just reported 10-20%.  It does affect the quality of life [00:09:00] in a similar way to congestive heart failure or rheumatoid arthritis. About 700,000 individuals present in the ER for constipation every year in the United States. And can you imagine, like, 10 billion is spent annually on laxatives?

Okay. So, when a patient walks into your office, and probably your 10th or 15th or 20th patient of the day, and they say, Doc, I’m constipated. That’s when all hell loose break, loose break, right? And you’re like, I’m ready to quit medicine, right?  But to be honest, it doesn’t have to be that way. And today I’m going to equip you with tools that you can use so that you know exactly what questions to ask this patient, what tests to order, and how to manage them, so that it doesn’t have to be that difficult. So when you walk out of this room today, you’ll be more confident in taking care of these kind of patients, okay? [00:10:00] So as we discussed, consultation is common, but it is challenging, and we have to have a systemic approach in evaluating these patients, so that we can treat them effectively.  However, I wish it was this easy. It’s not. So, what are the few questions that you’re going to ask the patient?  I’m going to give you two questions, which is going to kind of open your mindset as to where, which direction you would be going. The first question is, is it infrequent passage of stool?  That means they are not moving their bowel every day, or they are taking two, three days to move their bowels.  If that’s happening, if the patient said yes, then you have to stop thinking about slow transit constipation. That means the transit of the colon is not as well. 

The second question is, do you have difficulty with evacuation? Because if this is the problem, that they are not able to evacuate, then the problem is not because of the [00:11:00] transit, but you have to start thinking about obstructive defecation.  And one of the most common ones is pelvic dyssynergia. I’m going to go into details of all of this, but this, these two questions will kind of help you understand which direction you have to go. Also remember that constipation can be a distractor. That means there could be a lot of underlying chronic systemic conditions, the presenting symptom of which is constipation.

So you have to explore that. Just don’t think it’s constipation and just laxatives. We have to do more tests. We have to dig deeper into the root cause of that constipation. So this is a simple list, but it’s not complete as you can see, there’s a variety of conditions that can cause constipation. It could be hormonal imbalance like diabetes, hypothyroidism.  It could be problems with the uterine. Honestly, this meditation list is pretty short. It’s not a complete list, but these are the [00:12:00] common medications that can give constipation. So you have to ask the patient, did you change your medication recently? Is there something new that was added? And even old medications can take like a year or so, like calcium cannel blockers do have constipation, so we have to take that history.

Neurological disorders like Parkinson’s disease, spinal cord disorder, myopathic disorders, and of course we have to think about structural disorders like colon cancer, rectocephaly, things like that.  So what’s the next question?  Is this chronic constipation?  Is it because, you know, you were admitted to the hospital, had a surgery or a c section and you got morphine, maybe that’s why you’re constipated, then that’s not chronic, right?  That’s related to the opioid execute. So how would you know if it’s a chronic constipation? Well, if the constipation is present for at least three months for a duration of six months, that’s how we define chronic. And if it’s chronic, then you have to ask this question. Is it Functional Constipation or is it IBS [00:13:00] Constipation?

I actually got this slide from Gastro of 2020 and it summarizes very nicely what’s the difference between Functional Constipation and IBS Constipation. So with Functional Constipation, about 25 percent or more of the times they will complain of straining, lumpy stool, sensation of incomplete evacuation.  Very important, use of fingers to dis-impact yourself. This is extremely important and especially, I see this a lot of time in women and I’m passionate about it because middle aged women, they will come to you saying that they have been constipated all their life. And it started at the age of 18 and they have never had a regular bowel movement.  The very next question that I always ask them, do you ever use your finger to dis-impact yourself? And if the answer is yes, you already know that you’re dealing with an obstructive defecation, most likely pelvic dyssynergia. Okay, so that’s one point. And then in those cases, you [00:14:00] will never have loose stool.  They will always complain of hard, lumpy stool. As compared to IBS constipation, where it will always be associated with some kind of abdominal pain which is relieved with defecation.  The stools would be either infrequent or inconsistent and about less than 25 percent of the time they will say that they have a loose stool.  So loose stool is present in IBS but not in the functional constipation.

So, the chronic constipation could be either normal transit, slow transit, , dyssynergic defecation, or it could be a combination of the two. It could be slow transit with dyssynergic defecation. So a little bit about the slow transit, it is also called a lazy bowel syndrome, and as we said, there is decreased motility of the colon.  The etiology is really very poorly understood, but there could be a lot of things at play, like lack of fiber, it could be autonomic neurology, the interstitial cells of Cajal are actually the colonic pacemakers, and [00:15:00] sometimes abnormalities of those can decrease the motility. And we cannot undermine the role of, neuroendocrine, systems like pancreatic polypeptides, serotonin, because those also play a role in the colon’s motility.  This is different from obstructive dedication, as I said, and with dysnergia, especially in women, there is a problem with the pelvic floor which cannot relax, or it could be a spasm of the anal sphincter. Decreased rectal sensation, where even though stool is present in the rectum, they don’t feel the urge because the sensation is less.

So that can also happen. And then weakness in the pelvic floor, if they have multiple vaginal delivery, during this difficult childhood, they could have things like rectocele, internal collapse. And when you have, these things, they can either cause a physical blockage to evacuation, or sometimes they form these pockets, and that traps the vagal contents, causing obstruction.

So, how do you [00:16:00] identify patients with primary functional chronic constipation? So again, as we said, thorough history taking, asking them everything, when it started, frequency, medication. The visceral stool chart, honestly, we should all have this in our office, a big one on the wall. If you don’t have it, please carry it in the size of a pocket.

A picture. The reason is that I feel like whether you’re having soft or hard stool is a very relative term, which is soft or, , you know, formed for one person can be like a loose stool for another. So this picture kind of generalizes it so that it’s very uniform for everyone. And if your patient says that the stool looks like type 1 or type 2, you have to start thinking about slow transit constipation because why?

It takes, that means the stool is passing through the colon. For a long time. And what is the role of colon to absorb water from the stool, right? So if it stays in the colon for a longer time, your stool is going to get harder and harder And that’s why they have type 1 and 2, [00:17:00] then you have to think about slow transit.

This, the third thing that you have to think is I cannot actually, tell you how important a pelvic floor and anorectal exam is that you need to do on all your patients with chronic constipation. And I’m going to tell you six points that you need to look when you’re doing that rectal exam that’s going to give you so much clues as to what’s happening with the patient.

And then, ultimately you have to do the anorectomy for these patients to differentiate slow transit from pelvic dyssynergia, and we’re going to talk about that as well. So digital rectal examination. So the first thing, the very first thing is inspection. So even before you put the finger into the rectum, you have to separate, the cheeks with both your hands and look around.

What are we looking at? We are looking at external hemorrhoids. Is there a bulge? We are looking for internal hemorrhoids, which are prolapsed. We are looking for any irregularities because [00:18:00] then you have to start thinking about rectocele. You have to look at the vaginal area. Is there a vaginal prolapse?

You have to look at? If there is a scar, are we dealing with the anal fissure? Are the holes around? Are we looking at fistula? Right? So inspection is very important. We look at those things. The second thing is sensation. So we are going to do the endocritoneus reflex. So usually I use a Q tip. So one end has a cotton and the other end is like wooden and we are going to check that sensation in all the four quadrants at 9 o’clock, 12 o’clock, 3 o’clock, and 6 o’clock positions.

And if there is a contraction of when you do the, the reflex there, it’s normal. However, if you don’t see any contraction of the skin, then you use the wooden side. And if you see contraction now, then it is, abnormal or impaired. And the absent is when you, even with the wooden side, you cannot see any, , contraction.

Next is palpation. So when you insert the finger, you have to see the consistency of the stool. Is it a hard stool? Is the patient [00:19:00] impacted? If yes, then yeah, you’re thinking about obstructive defecation. Is there a liquid stool? Or is it no stool? So patient is constipated, but there is no stool. So yeah, this is slow transit constipation then, because the stool hasn’t come to the rectum yet.

So that gives you some clue, and if you have done enough rectal exams, you would know what a normal resting sphincter tone is, right? So that is something that we need to feel at rest, and after that, you tell the patient to squeeze very hard for 30 seconds, because you’re checking if they have enough strength, if there is enough squeeze there.

If not, you have to start thinking about problems with the sacral nerve and, , probably get an MRI. The next, we are going to ask the patient to push down, , thinking that your, finger is actually a stool and they have to evacuate it. Before the patient starts doing that, you have to put the other hand onto the patient’s belly, okay?

And then you ask them to push down. When the patient is contracting the lower abdominal muscles, [00:20:00] the sphincter in your finger should feel relaxed, right? However, if there is opposite, that means the sphincter is tightening and the abdominal muscle is relaxing, it’s a problem. If both of them is relaxing, that’s a problem.

If both of them is contracting, that is also a problem. So if you see any of this, you already is thinking in terms of pelvic dyssynergia and the next step would be to, do an anorectomy. So when you do the push down, you have to see what’s the push and pull. You have to see if the sphincter is relaxing or not, and you also see if there is a perianal descent or not.

So balloon expulsion test is a useful test to test that. I recommend doing it in the office. We do it combined with anorectal immunometry, where you insert a balloon with a catheter and fill the balloon with 50 ml of water. The patient is supposed to, expel it within 60 seconds. If they are not able to do it or take longer, then again you have to start thinking about therapeutic disinertia.

We always combine this. with anorectal [00:21:00] myelometry in our office setting. I’m not going to talk about that because Dr. Edmund is going to go into the details of how we do that after my talk, so you’ll get some overview there. Let’s get to the cheese effect, the treatment. Alright. Okay. So if you have diagnosed a patient with pelvic dyssynergia, , we recommend doing a pelvic floor physical therapy.

There are several exercises that we can recommend to the patient to strengthen their pelvic floor. And I know I said women, but men can also have pelvic floor abnormalities and dyssynergia. So there are crucial exercises for men as well that we recommend to our patients. This was a good study, which was published in the Clinical Gastroenterology in 2023, an office based point of care test that predicts treatment outcomes with community based pelvic floor physical therapy in patients with chronic constipation.

It’s very interesting that we used this [00:22:00] special balloon, and it’s a foam based balloon. As you can see, when it’s deflated, it looks like that, and then you inflate it with water. The benefit of this is that the consistency feels like that of stew. So it doesn’t feel like water or air for the patient, so it’s more natural for them because it has a consistency of stew.

I always believe in going back to the basics before we start, you know, the big guns. So lifestyle, we always start with this, right? Are we drinking enough water? 60 to 80 ounces of water or fluid every day. Are you getting enough exercise? You know, because if you are moving, your colon is moving. Are you having enough fiber in your diet?

Start small. I start with one fruit every day. So I tell the patient maybe have one apple, plum, apricot, any fruit which is like high fiber with the skin for breakfast every day. Start there and see how you do. Because sometimes that’s enough, you know. [00:23:00] And then this is, , something which I always encourage my patient that a lifestyle change, which is free of cost.

And trust me, your patients will be, their ears will be all open. They wanna know what that is. You ask them to drink a big glass of warm water every morning, okay? So there is no, you don’t have to buy anything. It’s free of cost, but it’s so helpful for patients with constipation. What it does is, because the water is warm, it’s going to cause basal dilatation, so it’s increasing the blood circulation to your gut, right?

And secondly, because it’s warm, it’s also stimulating peristalsis. So extremely helpful if the patient is kind of dealing with a slow transit kind of situation. , fiber, I’m especially a big fan of bulk forming fiber, but remember not all fiber is the same. There could be soluble fibers and insoluble fiber.

Psyllium is my favorite. It is also a prebiotic because it’s broken down by gut microbiomes into postbiotic metabolites like starchy fatty acids, [00:24:00] which in turn is helpful for gut, brain, gut, lung, and gut liver access. So extremely helpful, the patients have to drink enough water with the fiber for them to work.

And remember that fiber can sometimes cause gas and flatulence, so not every fiber is good for everyone. So your patients have to try different ones to see which one works best for them. So outlet obstruction, again, we talked about high fiber will work for those patients as well. , because sometimes the sensation in the rectum, as I said, is decreased.

So your job is to bulk up the stool so that the rectum is stretching more than usual. So that they have the sensation that now they have to go. So that’s why even fiber works in outlet obstruction. Sometimes we do warm water rectal irrigation. Biofeedback, very helpful in patients with NSMIS and reduced rectal sensation.

This is something we offer in our office setting as well. , Botox injection into the pubertalis, psycho, psychological counseling, pelvic floor [00:25:00] rehabilitation as I said. Surgery is the last resort, but you have to remember that about 50 percent of your patients will have recurrence of symptoms in six, in four years.

And therefore, again, going back to the basics and doing the basic stuff is more important.

I usually get asked, like, when I’m going to order the MRI. Honestly, whenever you feel that there is an organic abnormality, like you’re thinking about a rectocele, or a prolapse, or intersusception, that’s when you get an MRI. A few words about the laxatives. Osmotic laxatives really works well. Magnesium is one of my favorites.

And the docoset is actually a lubricating laxative, but only use that for a short term. I do not like to put the patient’s long term on that. And laxatives like Senna and Dopset, , they can cause a lot of cramping. So I usually don’t recommend that. And you can use the rectum forms too, if that’s what is preferred.

A few words about magnesium, because I love magnesium, but you have to remember that not all [00:26:00] magnesium salts are the same. So if the patient is having a constipation problem, We prefer to give Magnesium Citrate or Oxide, but some of my patients, for example, my all time favorite is Magnesium Glycinate. And especially in middle aged women, in perimenopausal women, somebody who’s like 50 years old, having constipation, but at the same time they’re having perimenopausal symptoms like hot flushes, anxiety, not able to sleep at night, I always combine magnesium glycinate.

Because it has a very calming effect on the nerves, especially in that patient population. So if you combine Magnesium Citrate with Magnesium Glycinate, in those patient population, you will see significant improvement, not only in terms of constipation, but also relaxing the pelvic floor, because it has a calming effect, the glycinate.

So just a few words about, the medication. So we have Elitesia, Lenz’s, TruLenz, and Multigridly. , I’m just going to say that all of this [00:27:00] works by increasing the colonic transit. So honestly, if you are having a patient with slow transit constipation, you can consider them, definitely. They are peptides.

But remember, we always need to have a discussion with the patient and not everyone is ready to try medications. If by your physical examination and your test you have established that this patient has pelvic dyssynergia or obstructive defecation, you do not want to use this because there is no problem with the colonic transit in those patients, right?

So be very careful because if there is an obstruction and you use this, it can be very uncomfortable for the patients. Again we are not without side effects. Sorry the slide is not very clear, but this is the um. Published in 2007, the side effects of amethysia, like abdominal pain, cramps, diarrhea, flash lens, , lenses, and the true lens, same kind of a side effect.

This is the new kid on the block, IBS Ryla. , it is minimally absorbed, and it’s a small molecule inhibitor of sodium hydrogen [00:28:00] exchanger isoform 3. It is recently FDA approved for iiv constipation. You give 50 milligram twice a day with meals and again, it has side effects, diarrhea, ulence, and oph pharyngitis.

So this is another option that we can use. So as a holistic gastroenterologist, I always try to think out of the box what is it else that I can give offered to my patient because not medication has less side effects and more effective. I’m going to share some of my tools with you. And this is one of my favorites, it’s Triphala.  If any one of you are familiar with Ayurvedic medicine, you would know that this is a very potent herb, which is used in Ayurvedic medicine. It’s a combination of three herbs, Hari Taki, Devi Taki, and Amla. And it’s used in Ayurvedic traditional, medicine for years for treating constipation and inflammation.  I’m very fascinated with Ayurvedic medicine, so if you know about [00:29:00] it, in Ayurvedic medicine, you classify individuals based on their doshas. And the doshas is kind of their personality or how the body works, and there are three types of doshas.

As you can see, Triphala kind of works in all the three doshas. In fact, in India, Triphala is not only used for constipation, it’s also used for weight management. So people use Triphala to lose weight, effectively without any side effects. So I offer this to my patients, usually it’s taken half to one teaspoon, you have to drink it with warm water.

Especially if you are treating constipation at night time, it’s great. , it also comes in pill form. I do like powder form. But if you’re doing the pill, it’s like 750 mg or something like that. But it has no side effects. Very potent. The other one is, use of MCT oil. So, MCT oil [00:30:00] is the same as coconut oil, but it has the medium gene fatty acids, which is more potent because it has 90 plus, as compared to coconut oil.

And how it works, it works by loosening the stool and lubricating the lining of the colon so that it’s easier for them to pass the stool. Vibrating Capsule, this is another service that we offer in our office as well. This was a study that was published by Rao 2023, and it showed that Vibrating Capsule was superior to Placebo Capsule.  It improved constipation symptoms and quality of life, and it was very safe and well tolerated. The patients inject one capsule, for five days in a week. And this study was for eight weeks, and it showed that they, improved bowel movements to one to two bowel movements every week. So the most common side effect of the vibrating capsule was the sensation of [00:31:00] vibration, which 11 percent of the patients felt, but none of them quit the study because of that sensation, so it wasn’t that bad.  So, However, you have to keep in mind that there are some contraindications. For example, you cannot give this, give this in pregnant patients, if the patient is needing a lot of MRI studies, what we recommend is that patients should be able to evacuate all the capsules before they go for the MRI.

And for the same reason, because of obstruction or a diverticulum, you don’t want the capsule to get stuck. So they, you have to rule that out before you give it to the patient. And, , remember that the capsule has to reach the colon. to start vibrating for it to be effective. So if your patient has gastroparesis, that will not be a great candidate because it will not be like, the capsule might start vibrating even before they go to the colon.

So you don’t want to, you want to exclude those patients. And then those are nerve stimulators, pacemaker, and defibrillators. We don’t want to give them those. So the, this is a study showing the benefit [00:32:00] of Nalgimidine, which is a re opioid antagonist in patients with cancer, so more like more opioid or morphine induced constipation have shown benefit with that one.

I’m a strong believer of the brain gut connection, the vagus nerve. So it starts origins, it has an origin in the brain and it goes all the way into your colon. The rectum, however, is innervated by the sacral plexus. However, I do believe that there could be sometimes a miscommunication between the vagus they are not communicating very well, and that can cause constipation.

And as you can see, the vagus nerve can aid in digestion, it can increase gastric juice, it can promote gut motility. So yes, if you stimulate the vagus nerve, your patients with autonomic neuropathy or decreased parasympathetic tone could actually have improvement in constipation. So, this is a stimulator that we also offer in our office, very easy to use, there are several locations.

There is another study which is showing the benefit of [00:33:00] transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation in patients with IBS constipation. So, you can use the vagus nerve stimulation either in the neck or, the yellow circle around the, , in the ear, you can use there to stimulate the vagus nerve.

But do you really need a device to stimulate the vagus nerve? Not really. You can tell your patients to do these things that will stimulate vagus nerve activation like meditation, exercise, singing, massage, cold plunges in Lake Tahoe, splashes of cold water, breath work, yoga, intermittent fasting, and just hugging each other more often is going to stimulate your vagus nerve.

So we have been proving the wrong way in America all along, right? So, the right way to poop is by squatting, because when you’re sitting, the puborectalis muscle has an acute angle, as you can see here. So it’s really difficult for the [00:34:00] stool to go all the way when you have that acute angle. And that angle really becomes straight when you’re squatting.

So I really, for all my patients with constipation, I tell them that they should be squatting, because squatting is the only natural edification process. And we should really be doing this. Sometimes there is a deficiency of bile in your gut and that can cause constipation. And there comes the role of a bile acid transporter inhibitor when I feel like this is the cause because this medication can decrease bile acid absorption and increase the colonic bile acid.

And that in turn is going to accelerate the colonic transit. So this was a study that was published in Practical Gastroenterology by Virginia Schur, , about almost a decade back. And she talked about the Bell’s palsy of the gut. So when you have Lyme disease, you [00:35:00] have Bell’s palsy, which is the paralysis of the seventh cranial nerve, and you have this drooping of the face.

And the similar kind of presentation can happen in the gut, where the nerve endings get paralyzed, and doesn’t move as well. So, in all clinicians with constipation, please ask them about, you know, the history of Lyme disease, like, did they have a history of tick bite, did they go hiking, camping, and had any target lesions?  Because, yeah, the constipation, in Lyme disease is a real deal. There are other studies here which are showing kind of a similar presentation of Lyme disease as constipation.

Dr. Weitz: Could I ask a quick question? Yeah. With respect to bile.

Dr. Sagar: Yeah.

Dr. Weitz: What about the use of herbal bitters to stimulate bile production or using ox bile as a supplement?

Dr. Sagar: Absolutely. Yes, you can definitely use bitters and we use that in our clinic setting too. You can use that to stimulate the production of bile. Absolutely. So use that. But that’s another option that I showed you. [00:36:00] Does that answer your question?

Dr. Weitz: Yes.

Dr. Sagar: Very good. So, not only constipation, but as you can see, Lyme disease can affect other, can cause other GI symptoms like bloating, abdominal pain, irritable bowel movements.  So obviously, keep that in mind, you know, just like whenever a patient with multiple GI issues comes to your clinic, start thinking about Lyme disease as well. Leg poisoning is another one, , it can cause constipation, so any patient with constipation I always check their venous leg levels, to see if, leg toxicity is the cause.  Autonomic neuropathy, again can cause constipation, and the treatment is really sacral neuromodulation, so in patients with Parkinson’s disease and Alzheimer’s disease we have to think of that. And then the gut microbiome. This is really important because they are the keystone species in the ecosystem.  And, these are the organisms that really help define an entire [00:37:00] ecosystem. And not only the gut, but several organs in your body have microbiomes. including your hair, nostrils, skin, vagina, oral cavity, esophagus, the composition of the bacteria is very different. For example, in your skin there is more actinobacter as compared to your colon which has more bacteroids and fumigators.

So it’s very different. It’s like really a whole ecosystem there. However, the gut microbiome is affected by a variety of things. It can be affected with your diet. We recommend a high fiber fermented diet if you want to improve your gut microbiome. It’s also related to physical activity. Use of antibiotics is going to affect it.

Hormones, for example, if a woman is on oral contraceptive pills, it’s going to affect their gut microbiome and cause constipation. Stress, because when you’re stressed out, the gut releases CRF. which increases the cortisol level and down regulates your immunity, and thus making you more prone to, stent infections.

Early [00:38:00] life trauma, if you have pets, the use of prebiotics, heavy metals, and, , you know, the pesticides, like glyphosate, all of this can affect your gut microbiome. This is a very small list of what a disruption of gut microbiome can do to you. I don’t have, this is beyond the scope to kind of list everything, but this is just a small list.

And really, when you have a disrupted gut microbiome, which is producing a lot of methane, there is an immune dysregulation that happens and immune suppression associated with vector like Borrelia, Balesia, and Boltonia can happen. For example, if you have, a methane producing bacteria, retinobradylbacter smelii, that is really linked to constipation, and that methanogen can also be seen in colon cancer, in colonic polyposis, in ulcerative colitis, and in diverticulitis.

Dr. Weitz: Can I, can I ask another question? Yeah. Methanobrevibacter Smithii, so [00:39:00] that shows up on a stool. We, we do a lot of GI map stool tests.

Dr. Sagar: Mm

Dr. Weitz: hmm. And methanobremy factor shows up.

Dr. Sagar: Yeah.

Dr. Weitz: Ideally, it should be below detectable levels, but very frequently, it’ll be above that. It may not necessarily be in the red.  Is that something that we should be concerned about?

Dr. Sagar: Very good question. So we never look at one thing only, right? Of course. So it’s always a whole clinical picture. Whenever we have a patient like that, you have to see what are the symptoms. Are they constipated? Are they bloated? Do they have a rash? Do they have food allergy? I would probably do a SIBO test.  I’ll probably look at the gut microbiome. I’ll look if they have leaky gut syndrome. So a combination of all of that. And based on what you found, we are going to treat that. We never usually give antibiotics targeted to just that bacterial, but yeah, if you have a clinical picture of SIBO or SIFO or leaky gut, then we do address that.

Dr. Weitz: Right, because there’s a bit of a [00:40:00] controversy now about methane SIBO or EMO because now it’s recognized that it can exist not just in the small intestine, but in the colon as well.

Dr. Sagar: Yeah, it can. 

Dr. Weitz: And the question is, you know, is seeing methanobrevibacter smithii on a stool test, can that be used to diagnose methane SIBO?

Dr. Sagar: I would say it would support the diagnosis, but you have to obviously combine that with the breath test and the clinical picture. But for example, , a load of, like when I’m talking about bloating and constipation, so everything is assigned and then you have to combine those, , the points that you’ve collected to make your clinical judgment.

Speaker 8: Right.

Dr. Sagar: So if you see something like that, definitely that’s going to alert your mind to see if this is like, aha, Methane, SIBO, and you’re probably going, it’s going to prompt you to do further testing, like a breath test, for sure.

Dr. Weitz: Okay. When you do the breath test. Do you recommend three hours or two [00:41:00] hours?  We do it for three hours. For three hours, okay. It’s alright, it’s two hours. Two hours. Two hours. Yeah. Because there’s this whole issue, how do you diagnose, , methanoprebi bacter overgrowth, EMO, in the colon? So we would either need a stool test or we would need a three hour breath test.

Dr. Rhabar: I don’t have a microphone, but I speak loudly.  I mean, as you put everything together, it has never been a necessity to check the colon. I mean, I’ve talked to other GI doctors. I don’t find it very helpful to go to three hours just to look for excess methane. There would be some other indicators that methane could be a problem. The other thing I think it is probably going to touch base, is that methane will be back to its beauty age.  Methane will be a killer. You know, microbe. Okay. And, , you have to remove the oxygen from the gut environment. And generally when you see this all way, look for a fungal marker. You’re going need to sit on organic acid. You’re [00:42:00] gonna see it on the same GI map you’re gonna see on stool culture. You’re gonna see fungal antibodies, is all the clinical picture basically speaks of that scenario.  And just as another commented, I practically would never treat a SIBO with methane directly. Targeted towards the SIBO, we generally target the fungi first before you attack the methane, okay. Because the potential for giving antibiotics and switching the microbiome to a more fungal predominant is very high.  And if physicians follow the patient, they’re going to see that the effect of the benefit from the SIBO treatment is generally temporary. It’s going to come up with some other recurrence if the fungus is not addressed.

Dr. Weitz: , Sunomidressum can currently address the fungus first with something like Nystatin or

Speaker 11: would

Dr. Weitz: it?

Dr. Rhabar: Well, I mean, there are many ways to address that and it probably is another hour or two to have a discussion. Yeah. , but the short [00:43:00] version is that we treat the fungi first with Diatin, the antifungals that would be appropriate for that patient. Biofree musters. And then if we plan to treat the SIBO, then I usually keep the patient on an antifungal concurrently.  Otherwise, in my experience, you’re going to get a microbiome switch. You’re going to you’re going to have fungi have more accuracy because of their behavior. And you know, even though some of this is not completely U. S. literature, but there’s information out there from the Europeans that we have

Dr. Weitz: to

Speaker 11: get through.

Dr. Weitz: What’s your favorite biofilm busting strategy?

Speaker 11: How about we let you finish up the presentation? 

Dr. Sagar: I have a tweet for you at the end.

Speaker 11: Okay.

Dr. Sagar: Because you asked me that question.

Speaker 11: Thank you.

Dr. Sagar: Alright, so let’s get back here. So we have, we always have those patients who are constipated and they’re also bloated, right?  So that’s like a perfect combination. [00:44:00] But remember that not all bloaters are the same. And how do we differentiate that? So you could have some patient who would have constipation and bloating, but they will also see that I always have rumbling, like my stomach makes so much of noises that my partner who is sitting across the table can hear that, right?  And then when you put the stethoscope into the belly of that patient, you’re going to hear a lot of noises. As compared to silent bloaters, where they would see that they are pretty big, like bloated, But they don’t hear anything, like there is no rumbling, and when you put your stethoscope into the belly of those patients, it’s pretty silent.

So that tells you that probably the colon is not moving as well as it should. So it is probably a slow transit. Again, there could be an upstream problem, because the classic definition of SIBO is abdominal pain, bloating, constipation, and diarrhea. So, [00:45:00] if you have a patient who is constipated and bloating, I do recommend doing the SIBO testing.  And, again, a huge list of things that, , would indicate a SIBO breast test, including constipation. And I wanted to bring your attention to this, the yeast, , function, because when you have a fungal overgrowth of the yeast, um and Overgrowth, that can drive a Th17 response, which can sometimes protect from pathogens, but when you have a disregulated Th17 response, it can cause inflammation, it can cause leaky gut, it can upregulate the immune system, and cause autoimmune conditions and, , constipation as well.

So, we are going to have, a case presentation, just to kind of keep up our interest. So I have a very lovely 40 year old female who presented with multiple GI symptoms. She had indigestion, constipation, dyspepsia, flashlights, malaise, fatigue, [00:46:00] distention, so she was bloated, she had nausea. When we did the breast test, she had a methane sequoia test, which was abnormal, and then when we did the food allergy testing, she was allergic, she was allergic to multiple food items.

We did the Heidenberg gastric pH testing which showed some bile reflux and pyrolytic insubstituency. This stool test showed some Klebsiella, so she has a dysploric, , gut microbiome, and there was some candida in the stool as well. We did the urine mycotoxin screen and she was, , highly abnormal. The gluotoxin levels were 18 times that of the normal.

The live screen was positive as well. This is her endoscopy picture and this is the stomach. Usually, the stomach should not have this yellow stuff. So this is bile. When you see that, it means that there is a bile reflux and bile really has no business in the stomach. It is supposed to be going into the small [00:47:00] bowel and downstream from there.

So this patient, just to make you understand, the bile is produced over here. So, for the bile to go back into the stomach, it has to pass the pylorus, and usually that’s not the normal route. The bile should be produced and go down over here. So whenever you have a case like this, where a patient has bile reflux and constipation, the upper GI and the lower GI, you really have to target the middle man here, which is the small bowel.

So, this patient was treated for SIBO, for fungal overgrowth, and she was also treated for SIBO. With that treatment, her constipation significantly improved. And there was a special thing that we used on her, which did not only address the C4, the bacterial fungal overgrowth, but also the constipation. So to answer your question, we used Diamethaceous Earth in her case.

So Diamethaceous Earth, not only helps with the C4 treatment [00:48:00] because it’s a biofilm buster, but also with constipation. So what is Diamethaceous Earth? Well, we all love the ocean in Southern California, right? So when you go to the ocean and you look at the bottom of the ocean, there are these dye atoms and there are these crustacean organisms which were made into food grade and used as a biofilm.

So it kind of detoxifies the colon and cleanses it. So, the biofilm is disrupted and also it helps patients with constipation. So this really helped our patient therapy. So take home message is always do a thorough rectal exam in all your patients with chronic constipation. We have to stop thinking about pelvic dyssynergia because it is very common and underdiagnosed.

We have to consider balloon expulsion test with anorectal manometry in all our patients. It’s going to help you differentiate slow transit from obstructive defecation. Constipation is a very common problem and sometimes you, it’s a distractor, that [00:49:00] means there is something else going on with the patient and they present as constipation.

So we have to wear our detective hats and get to the root cause of what’s causing the constipation. And SIBO whenever you have a patient with abdominal pain, bloating, constipation, diarrhea, food allergies. Methane SIBO is associated with agonist constipation. And if you have a negative febrile test in patient with bloating, bile reflux, and IBS constipation, it may indicate the presence of a fungal overgrowth and febrile.  Thank you so much for your attention. And with that I’ll come to the end of my presentation. I’ll be happy to take any questions, but I know that Michael has prepared some slides for anorectal manometry too. So in the interest of time, I’ll have him come over and do his presentation.

Michael: Thank you for being patient.  And I’m Michael [00:50:00] Erdman. I work with Dr. Sagar and Dr. Rahbar and I’m going to give a very brief talk on anal rectal manometry because that’s what I do in the office. And it’s very interesting when you have certain cases of chronic constipation, it’s a very useful tool. So the purpose of my little brief talk is to, make you very aware of why you should refer some of your patients for this test.  that’s the button there. So brief objectives, basically just to, you know, get that message across the importance of ARN. And pretty much what Dr. Sehgal was saying, you know, one in three patients with the first line treatments for chronic constipation failed treatment. They’re the ones that you start thinking about, you know, The indication of, you know, wanting to assess their pelvic floor and to get them a anal retinometry so that you can see if they have a functional defecatory issue.

And why? And it’s basically because laxatives and fiber [00:51:00] therapies are not as effective as biofeedback and pelvic floor physical therapy. John’s already gone over this, so I’ll skip past it. and also the buzzwords in a clinic, the digital facilitation of defecation. These things you always think, anal rectal manometry, pelvic floor, physical therapy, and biofeedback.

The detailed rectal examination can actually pick up about 70 percent of cases of dyssynergia. And that’s what an ARM machine looks like. And these are the types of tests that you, , the ways that you can analyze a patient’s, , issues. So the first thing you look at with ARM is the anal sphincter pressure.

And then after that, their ability to squeeze and how effective the sphincter is at doing that. , the next thing would be looking at the myenteric plexus, and the recto anal inhibitory [00:52:00] reflex, which is abnormal in patients with Hirschsprangs, for example. The sensory motor response with hyposensitive patients that have a distended rectum.

Rectal compliance, which is, , something that you see, , that’s all about the pliability of the rectum, and whether, , , for example, elderly patients have a stiffer colon, and, , patients with Hirschsprung’s, for example, would have a more distended rectum. And then there’s the defecation tests, which is all about disinertion defecation, which is the really interesting bit.

So this is pretty much what you’re dealing with with ARN. You’re looking at a lot of, a lot of graphs. And there are four balloons attached to this catheter and they’re positioned posterior, anterior, left and right of the internal anal sphincter. And they’re color coded and then the colored heads come up on a graph.

So. When you ask a patient to squeeze, you’ll see the activity of [00:53:00] that and you’ll see the anal sphincter response. So a squeeze initially is a biphasic wave pattern. There’s initially a big spike, and then there should be this prolonged duration when you ask someone to try and squeeze for 20 seconds. If they have problems with incontinence, they’re not able to do that.

This is actually a reasonable squeeze pressure. It’s not too bad. This is a much better squeeze pressure. It’s not entirely symmetrical, but they can sustain it for 20 seconds, so that’s totally normal. So these are the kind of things I want you to see with what the, what the testing is for your patients.

Someone who has a low squeeze, , that’s a very poor effort of a squeeze, can be poor compliance. Then you start thinking neurological problems, damage to the sphincters. If it is poor compliance, they do well with biofeedback, which is something that we offer in the office. Whenever you look at someone’s ability to squeeze, you look at the cough reflex as well because [00:54:00] you see them together.

So a cough reflex, when someone, when you ask someone to cough, the abdominal pressure rises and then the anal sphincter muscle contracts. So it’s intact, with patients that have upper motor neuron lesions, and then it’s not if it’s a chordaequine lesion. So when you look at someone who has a poor squeeze and a normal cough reflex.

you think it could be poor compliance, or it could be a central motor pathway issue. And then the other way around, it would be, if it’s a poor squeeze and there’s no cough reflex, then you think an issue, for example, with the sacral reflex. This is a very high squeeze. Now, you see this in male patients that have chronic pelvic pain.

When they have a high squeeze, they usually have a very tight anus. I said that on camera. And, , you see that and typically they also have type 1 dyssynergic defecation, which is something that I’ll [00:55:00] show you. Rectal sensation is another part of the test. This is your ability to see how your patient has, what they can feel, as you inflate this balloon inside them and the balloon gets bigger and bigger.

And you say, let me know when you first feel it. Let me know when it gives you a desire to have a bowel movement. Let me know when you can’t take it anymore and you need to run to the bathroom and let me know if you have any pain. If they have pain, you stop. This is an example of someone who’s actually hypersensitive because they had a desire to go, and then with a very similar pressure, they had urgency.

You use this test to look for hyposensitivity and hypersensitivity. Hyposensitivity, they would not be able to recognize two of these sensory tests. For example, if they can’t feel anything in the beginning, you see that with diabetes. If they don’t feel a desire for, or urgency, for example, that’s with [00:56:00] constipation.

So I’ll skip this bit. , the sensory motor response. That’s when you inflate the balloon. Someone should have a urgent desire to go to the bathroom. If they don’t, that’s a sign of hyposensitivity. And then the myenteric plexus, which is that the neurons and ganglia in between the longitudinal muscles and the circular smooth muscles that work with peristalsis.

There’s a lovely test with the A RM, which is the recal anal inhibitory reflex. When you inflate the balloon, what you should see is a relaxation of the internal aim sphincter, and this is how it looks. So you have a nice increase in the rectal balloon. You know, it’s been pumped up here. and then you see a decrease of all the anal sphincter muscles.

This is a very good example of an intact rectal anal inhibitory reflux. And that’s how it also shows itself with ARN. It’s the same way. You can see all the internal anal sphincter muscles [00:57:00] relaxing at that point there. Compliance. This is all about, like I was saying, the kind of ability for the, , , rectal space to.

accommodates the increase of the stool in that zone and it changes as we get older and also with scarring to the rectum and it’s, , there’s actually a higher compliance with megarectum and faecal impaction. And then this is what dyssynergia looks like, which is really what our talk is all about, in regards to ARN, so What should normally happen is you ask someone to push when they try and poop, they push, and then the anal sphincter muscles relax.

So this would be a normal looking defecation on ARN, and this is how it would look on, on the report. Dyssynergic defecation, there’s four types. The [00:58:00] first, this is type one. It’s where you ask a patient to push and they can push really well. that the anal sphincter tightens up, right? So the pressure rises instead of falls and that’s, that’s very abnormal.

Type 2 at the top would be they don’t have a very good push and the anal sphincter muscle tightens up inappropriately. Type 3, They have a very good push and the sphincter doesn’t really tighten up. It doesn’t really do anything at all. And then type four, nothing’s working. You know, they can’t push and they can’t relax the anal sphincter.

So this is a case that I had where a patient came in with a hugely abnormal squeeze pressure reaching, you know, 300, , points on the squeeze, which is super high, like really damage your finger on a retinal [00:59:00] examination. And he was very proud of that. And then, , you know, when you, when, when he did his dis inertia defecation test and I asked him to try and replicate having the bowel movement, the balloon inflates.

And as it, as he’s pushing, you see the anal sphincter muscles are rising as well. So this is type one. Dyssynergic defecation. So if I go back to where we were, that’s what we’re looking at here, right? So you had a type 1 dyssynergic defecation with the balloon inflated and not inflated. So he was, he came back and had biofeedback with us.

Biofeedback is very similar to ARN. They look, they can look on a screen so they can see they’ve got a catheter in the bottom and they can push and when they push they can see the rectal pressure rise. and they can also play around with their pelvic floor and try and work out how to make the anal sphincter relax.

The first time he [01:00:00] came in was on the left, and you can see this was after multiple rounds, he couldn’t quite get it. On the third session, he came in with a higher anal sphincter pressure than he did on the first, the first attendance, but he had a perfect correction of his dyssynergia. Which is amazing, you know, and these, these are patients who have huge problems pooping for a very long time, right?

So, moments like this are great, and that’s the benefit of anal retinometry, that’s the benefit of biofeedback. Typically, they do much better when they have pelvic floor physical therapy at the same time. And so, then the balloon expulsion test we’ve already gone over, and I’ve already mentioned this, And Dr.

Sehgal already mentioned this article, but what was interesting, in addition to what’s already been said, is it also mentions the importance of paying attention to squeeze pressure, squeeze duration, [01:01:00] especially with an abnormal balloon expulsion test. It indicates a very good response to pelvic floor physical therapy and biofeedback.

The problem with the reports is it’s very, it can give you a mental block trying to figure out what’s going on. So Dr. Rabar and I, a couple of years ago, had had enough, and we came up with our own version, which, so now whenever people come to see us for ARN, we send them home with a lovely report. It goes to the practitioner.

Any questions you can get in touch with us. And it’s very informative so much so that the company, , Purchase the report from us as well. So now everyone has access to it, but it’s another way, a very informative way of understanding the outcome of your patients that you refer. So just to clarify once more, chronic constipation cases that fail that trial, [01:02:00] you think ARM, balloon expulsion testing, because it’s thought that there’s 50 percent of these cases out there that are actually functional, , dyssynergic problems, and only 2 percent are tested with anal retinometry.  The most important thing is getting these patients the treatment that they actually need. Biofeedback, pelvic floor physical therapy, that’s what it’s all about. As rapidly as possible. And treatment, you can actually help dyssynergia cases up to 90 percent of the time. So, it’s very valuable. And that’s actually the end of my talk on Anal Rectal Manometry, and I just came up with that.

 


 

Dr. Weitz: Thanks for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy, Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues, like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310 395 3111 and we’ll set you up for a new consultation for functional medicine and I look forward to speaking to everybody next week.

Julie Stevens discusses A Holistic Cancer Strategy with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

1:29  Cancer diagnosis.  Julie Stevens talks about being diagnosed two years ago with stage 4, aggressive and inoperable chemo resistant colon cancer.  She had no signs or symptoms but she had low iron on labs and her primary care physician recommended an upper and lower endoscopy.  Her gastroenterologist told her that she did not need a colonoscopy since she was under age 45 and had no family history, but she insisted to do the test and the gastro woke her up and told her that she had a tumor so large that she could not get the camera through.

3:19  Insistence of data.  Julie’s colon closed and she had to get surgery to remove 12 inches of her colon and 61 lymph nodes.  She met with her first oncologist who told her they would do 6 months of chemo and then do a PET scan.  But Julie wanted to test the treatment for efficacy as they went, so she refused to work with that oncologist.  She set out to build a team around her that would help her to track if the treatment was the right treatment for her as they went along. She hired an herbalist, who told her that she needed to stop eating sugar and that she could test her tumor DNA to find out if the treatment would work. She did this test and found out that her tumor would not likely respond to traditional chemo, which she told her oncologist. But she went through two chemo sessions and she tracked her response by looking at a lab test that indicated that it was not helping her, so she refused further chemo.  Then she went through immunotherapy. 

7:54  Immune System Balance.  Julie also worked on building up and balancing her immune system, so that her cancer treatments could be more effective.  She focused on her diet, getting plenty of sleep, and exercise. She also was suffering with GERD and idopathic urticaria, for which she was taking biologocial shots every two weeks and eight Zyrtec a day and 3 different pharmaceuticals.  She got off her acid blocking medications and she did food sensitivity testing from Dr. Russell Jaffe and discovered that the green grapes that she was eating every morning were giving her hives.  Not only did changing her diet and lifestyle help her control her uticaria, which allowed her immune system to focus on the cancer and allowed the immunotherapy to work better, but she also lost 140 lbs and had a complete body transformation. 

13:14  Diet.  Julie started to eat organic and initially was eating grass fed beef and eggs.  She still eats eggs nearly every day and some seafood and some poultry, but she now does not eat as much meat. She focuses on getting five colors of vegetables a day. And she eats zero sugar. 

 



Julie Stevens had a successful challenge with colon cancer and now she is helping others have a successful journey through her MOJO Health website.  Julie published a book about her cancer healing journey, Mojo Healing.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz: Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, drweitz. com. Thanks for joining me, and let’s jump into the podcast. Hello, Rational Wellness Podcasters.

Our topic for today is building a holistic healing strategy and maximizing joy on a cancer journey. We’ve had a number of discussions on the podcast. on an integrative or functional medicine approach to helping to manage cancer patients, including Dr. Nalini Chilko, Holly Lucille, Naysha Winters, Thomas Seyfried, Paul Anderson, Elise Altshuler, Gio Espinoza, and others, [00:01:00] but only a few with someone with personal experience with cancer. which is what our discussion today with Julie Stevens is about. And Julie will share her experience of how she developed a strategy and worked her way through a successful cancer journey.  Julie, thank you so much for joining us today. And perhaps you can start by telling us a little bit about your journey.

Julie Stevens: Yeah, happy to. So hi everyone, my name is Julie Stevens and today is probably my 45th birthday, so I just want to remind everyone who’s listening to be a DataG and go get your data.  That could be colonoscopies, mammograms, or annual physicals, but get your data because that’s really the story of what’s unlocked in the cancer journey.  So, it was just shy of two years ago I was diagnosed, so it was June 14th of 2022, I was diagnosed with what ended up being stage 4 aggressive and inoperable chemo resistant colon cancer.

Dr. Weitz: A heck of a diagnosis. That’s a hell of a diagnosis for anybody to deal with, especially somebody who’s new to, really, the healthcare world.

Julie Stevens: With no symptoms, no signs, no family history, under the age of screening, which was 45, so it really was.

Dr. Weitz: Which is interesting how you say you had no signs, no symptoms, and it just is something that we all need to keep in mind.  I hear so many people say I’ll let my body tell me what’s going on, and unfortunately, sometimes that’s not the case.

Julie Stevens: For me, it was just, I had lower iron than I’ve ever had before. And luckily my primary care physician took that really seriously. And I was just in the middle of a major work transition.  I was leading a piece of an acquisition we were, we had just purchased. And so my life was wildly stressful and I thought I had an ulcer. And she said, let’s go ahead and get an upper and lower endoscopy. And so I called my gastro three times. They told me, you don’t need a colonoscopy. You’re under 45. You have no family history.  And my response was like, I’m a data gal. Let’s just go ahead and get it. I’m willing to do the prep. So let’s get the data. And thank God I did because my gastro woke me up and said the tumor was so large. They couldn’t get the infant size camera to the other side.

Dr. Weitz: Wow.

Julie Stevens: That was the beginning of my journey in June of 2022, and in July of 2022, unfortunately, my colon actually closed.  So I had to go get a right hemicolectomy and have about 12 inches of my colon removed and 61 lymph nodes. Those came back, and of course, the cancer had spread. And so they had suggested six months of chemotherapy. And while I don’t know really anything about science, I’d had the luxury during the rollout of Obamacare of working with the American Hospital Association in the world of industrial psychology to define different jobs, so I understood the job and the industry of healthcare very well.  I just didn’t know science. But also taking into account my history working in the field of industrial organizational psychology, I understand how to use data to predict outcomes. That’s what I do every day. And so when the oncologist said, we’ll do six months of chemo and then we’ll do a PET scan, I said, oh no, that’s not my story.  We’re actually going to do six months, like right after the first chemo, I’d like to test for efficacy. And she rolled her eyes and said, oh honey, that’s not how we do it. So in this condescending voice, and I was like, then I’m not going to do chemotherapy. And that was the moment I went rogue because I don’t know science, but I knew data.

And if they weren’t willing to let me track the data my way, I didn’t trust that doctor. So I had to start from scratch and really build a team around doctors that would really suit what I was looking for. And I even built, again, as I’m using my industrial psychology hat. a criteria for what I’m looking for in a doctor, and actually built a selection system to find the doctors that would really play my way.  And my way was using the most current data, willing to think outside of the box, willing to challenge the standard of care. I understand why the standard of care was created, and that was to create operational efficiency. I helped organizations understand how to do that. So, I don’t look up for Operational efficiency. That’s exactly right, and that’s [00:05:00] not what I’m looking for when your life is on the line. I’d have 14 percent chance of survival.

Dr. Weitz: Interesting. And we see that all the time, unfortunately, in conventional medical care.

Julie Stevens: That’s exactly right. So luckily my first, the first hire on my team I would say was an herbalist and I walked into his office thinking he was going to tell me to align my chakras and stop eating sugar, which he did.  But in addition to that, I said, he’s like, why are you here? And I said I want to understand the data I can measure, I can use to measure treatment efficacy. And he’s oh yeah. And he pulled up a website from cancer. gov and it had,  And then he goes, but wait, I can top this. Do you want to understand the data you can use to predict if the treatment will work before you ever start? And I was like, yeah, I didn’t know that was possible. And then the third thing he told me was, listen, we can not only do that, we can build your body up so you won’t feel the side effects.  That had my attention. So hence, right away, he was hired onto the team. And in fact, he did all three of those things. So I knew I was chemo resistant before I started. My oncologist did not trust me and told me, trust me, I know what I’m doing. I’m the expert. And so I went through two chemotherapy sessions where I tracked my data outside of what they were doing.  So I was able to identify I was chemo resistant, inform my oncologist about this, do the required testing, and then pivot to what actually worked.

Dr. Weitz: Wow.

Julie Stevens: But it wasn’t just the herbalist. I also had hired, I should say, an acupuncturist, a reflexologist, a chiropractor. So I had all sorts of traditional healers all designed to really heal different parts of my body as my oncologist was working on treating cancer cells.  So I really felt like it’s up to me knowing 92 percent of cancer is built because of what we eat, drink, think, and do, or epigenetics. So it was up to me to figure out why the root causes of cancer were expressed, because it wasn’t genetic in my case, and to also use the best of any science that was available.  And for me, the science that worked was science that was released in 2020, 2022, 2023. So it was very real, like it was happening real time as I was going through my treatment. And that was not the way my, my oncologist was working. And he was the chief of staff at a major academic health center in Atlanta.  So this wasn’t a slouch or a small person I was working with,

Dr. Weitz: My podcast is devoted to Functional Medicine and you just beautifully explained what the Functional Medicine concept of how we treat patients is by looking for the root causes, getting your body as healthy as possible to be able to handle whatever care we’re going to have etc. So that was a great statement of the functional medicine mission statement without even really having any experience in functional medicine.

Julie Stevens: That’s, that’s the part of this that’s been the most shocking to me, is that I truly did not understand how much power we had when we build up our immune systems, and how critical it was, and how hard it is in today’s world.  I’ve had to change just about everything about how I live, from the food I eat, to the activities I do, to the stress I keep, and the sleep I make sure I get, and the rest. And it’s really difficult to do that, and it really takes a lot of effort when you think about how we actually live in today’s standard American lifestyle.

Dr. Weitz: What you just said about the immune system is really significant. I don’t think most patients, even cancer patients, understand that without your immune system playing a very vigorous, active role in helping to kill cancer cells no matter what other form of treatment you get, whether it’s the strongest chemo in the world, whether it’s the strongest radiation.  You’re only going to kill a certain number of those cancer cells, and there’s always going to be a certain amount of cancer cells that are not directly killed by that.  And that’s your immune system needs to be stepping in and playing an active role. And then whenever you stop your treatment, the immune system needs to be continually working on eliminating cancer cells and controlling their growth, etc. Or your care won’t be effective. And of course, you utilized immunotherapy, which is an example of some of the newer forms of cancer therapy that involve getting your immune system to play an even more active part in eliminating cancer.

Julie Stevens: I think it’s important to note though, while immunotherapy was a huge part of my strategy, I had done all sorts of work to my body so that the immunotherapy would work. So I’d gotten off of the medicine for my GERD. I also had looked at every single reason for inflammation. I think this is a really important part of my story of before cancer, I was diagnosed with cancer.  I’d had a disorder called chronic idiopathic urticaria. That means for every day for 13 years, I had hives. Sometimes from head to foot, I was miserable. Sometimes I couldn’t even brush my hair or hold a pen or walk because of these hives. And I had gone from doctor to doctor to doctor to figure out what was driving these hives.  And everyone just put me on more pharmaceuticals. So before I was diagnosed, I was taking biologic shots every two weeks, up to eight Zyrtec a day and three different pharmaceuticals to mask the hives. And it didn’t mask the hives. So flash forward to, listen, my very first meeting with Oscar, my herbalist, he said, we’ve got to worry about your inflammation because cancer feeds on sugar, inflammation, and copper.  So let’s go ahead and figure this out. And he did this test that was by Dr. Russell Jaffe. I’m not sure if you’re familiar with him. It’s an ELISA.

Dr. Weitz: Oh yeah, He’s been on the podcast.

Julie Stevens: Sure, it was the ELISA LRA test.

Dr. Weitz: And it’s like a food sensitivity test.

Julie Stevens: Exactly. And it unlocked every single reason why I had hives. So for 13 years, I’ve been miserable with this diagnosis. So not only did I heal the cancer, I healed the root causes of why I had so much inflammation. And I had to do all that preparation work for the immunotherapy to work so flawlessly. And it’s important to say, not only from immunotherapy, but also chemotherapy, I didn’t have side effects.  I was going to music festivals in Mexico during treatment, and that doesn’t happen to the average person. But because I’d done such a beautiful job of having enough magnesium and vitamin D and vitamin K, my body rode through the waves without any problem.

Dr. Weitz: That’s great. So explain how preparing your, explain how getting off your Omeprazole and doing some of the other things you did to heal your body, how did that play a role in helping your body fight cancer?

Julie Stevens: I think the important part is you want your body, and the way that this was described to me by my healers was, listen, you have an army of ten, and when you deploy your army so that they’re worried about this inflammation, and this, you have this glig plug in that creates this, and you have this toxicity, and this chemical that you’re having a reaction to, and you’re using this makeup, your body’s fighting all these wars, there’s no troops to fight cancer left. And we want all of the troops fighting cancer. So the job is to create homeostasis in every way you can so that your troops are focused on what’s important. That’s cancer cells, not on helping to moderate the impact. Because for me, it was green grapes. I was poisoning myself every morning by eating green grapes because that was my favorite food.  And come to find out that was giving me hives every single day. So, by helping my body avoid fighting the trauma of green grapes and focus on cancer, I was able to heal that. But, I think it’s important to notice, besides the, the urticaria, besides the cancer, I’ve also had a complete body transformation.  So, I’ve lost 140 pounds, every single part of my body, if you were to look at my blood markers, I look like a totally different human being. But, it’s because I was able to refocus on grounding myself every day, getting enough sleep, really healing my body the way it needed to be healed and giving it that homeostasis so it could work in its most functional, optimal option way.

Dr. Weitz: What sort of nutritional approach have you been using in your Cancering journey?

Julie Stevens: The first thing I [00:13:00] did was kind of anything that was non-organic left. So I really started to use grass fed beef and eggs and all the things. But then I started to so first thing was just as clean and as pure as I could without any chemicals.  But then I started to really get choosy about the types of food I eat. So the majority of my diet is plant based as much as I can. I do eat some seafood, I eat eggs every day, and I have some poultry but not a huge, not a ton. So I’ve really been able to shift that to be almost all plant based. I make sure I focus on getting five colors of vegetables a day.  That was my challenge for this year. Once I understood the different nutritional value of having green versus red versus purple vegetables. I understood that you can’t just eat a bunch of broccoli and think you’re going to have enough. It really is the diversification that allows your gut microbiome to really thrive.

Dr. Weitz: So you reduced your consumption of animal protein?

Julie Stevens: I did. And for me, as I mentioned, I did the ELISA LRA test and it [00:14:00] showed gluten, soy, sugar, green grapes, tuna, and scallops. So I have completely eliminated those things from my diet. Sugar was probably the hardest. And that still is the hardest because when you travel or eat out, you never know if sugar’s in the sauce or the, the salad dressing or things like that.  So it is challenging to really make sure you have a zero diet, a zero sugar diet. But as much as I can, I’ve gotten, gone to zero sugar. And then of course gluten was the thing that was, is, was a challenge to begin with. But really the reality is there’s so many beautiful gluten free products now, I don’t even miss it.

Dr. Weitz: Did you change your diet around the times that you got your treatment?

Julie Stevens: Oh, yeah, I so I should say my treatments don’t look like the average person’s treatment. So I think that’s okay. So when I did chemo, yes, I fasted. So I didn’t, I didn’t, I really, So part of my my training as an industrial organizational psychologist was I broke down every single [00:15:00] side effect that could impact me during the treatment, and I built a plan to moderate it.  So that’s part of why I didn’t have side effects. So I fasted for every single infusion. I made sure I had

Dr. Weitz: Did you fast for how long?

Julie Stevens: 24 hours before for the 24 hours of the infusion and six hours later. So I really tried to do before and after. I also like iced. So cold sensitivity, I was on oxaloplatin, cold sensitivity is a reality for that one treatment.  So I put my hands and feet in ice and I ate ice chips the entire time. So I had no problems with cold sensitivity. I had to fight really hard against my healthcare system to allow me to do that. But I was able to avoid that entire side effect of any cold issues.

Dr. Weitz:  Cool. What are some of the other important lifestyle factors that you utilized?

Julie Stevens: So you mentioned one when we started and that’s, you mentioned my mantra of maximizing joy. And I think that’s a really interesting one because that is something that’s kind of uniquely me and I think in my journey. I [00:16:00] decided when I was diagnosed and because you feel overwhelmed with fear and I immediately decided I will not do this journey in fear, I will do this journey in joy.  And that takes a lot of mental practice and really work to be able to do that. So I started to feed my mind superhero movies. So instead of watching the news, I watched Iron Man to understand what I could do. So I read books, I asked my network to send me pictures of rainbows and puppies and, flowers and all of the things because I really wanted to utilize

Dr. Weitz: In other words, Marvel Comics is directly responsible for your recovery.

Julie Stevens: For me thinking I was a superhero, that’s fair. That’s fair. And I brought that in. So part of my strategy is I went to my first treatment and I hated being there. As you can imagine, it is the worst place on the planet when you look around and you think all of these people are dying around me. And that’s what I thought.  And I thought, I can’t have this energy. So the next one, I got dressed in costume. And I brought, so basically I decided to have a [00:17:00] luau. You can imagine I walked into my second, my, my first chemo, my second chemo, my first party and walked in and said, Hey, you want to get laid in chemo and had lays for everyone and glasses and gift bags and, But part of those gift bags were I had a lot of frustration.

So I hand hammered bracelets for everyone that said, ride the wave. And I gave out 60 gift bags that day. So at the end of my first meeting this woman walked up to me and said, listen, Julie, I was planning to commit suicide tonight, and I’m not going to, because I met you and I know I can ride this wave.  And I realized right then I might be the only person that’s crazy enough to get dressed in costume and give, bring gift bags to an infusion, but every single person here needs it just as I did.

Dr. Weitz: Right. Awesome. You discuss how you use genomic data to predict treatment success. Can you tell us more about that?

Julie Stevens: Yeah. So this is pretty cool. And I think for, I’m guessing most of your listeners know this, but for anyone who doesn’t, I thought colon cancer was a thing or breast cancer was [00:18:00] a thing, but come to find out, it kind of matters where it is, but really what matters is the genomic makeup of the tumor cells.  So for me, I was a GKRAS13D, was what my tumor cell was genomically named. Well, come to find out, because I was KRAS positive, my herbalist had done research in lung cancer that showed that the platinum based chemotherapy wouldn’t work with a KRAS positive tumor. So I brought this research and my genomic data the morning of my first chemo to my oncologist and I said, listen, this isn’t going to work, let’s just go ahead and pivot to immunotherapy.  But come to find out, because of the standard of care You have to fail at chemotherapy before they’ll open up immunotherapy. He didn’t know I understood why he was forcing me to do chemo, but I understood the red tape was there because of my experience working in the field of industrial psychology. So I laughed.

So I was like, all right, I’ll do this, but I don’t trust you. But it was really the understanding the genomic fingerprint, which is required to have some sample of the tumor. So it’s not possible for all cancers right away, [00:19:00] but as soon as you can get this, I would implore you to utilize this data. And let me share, I didn’t call one time to get this data, I called over 20 times to get my oncologist to pull this data.  This is not standard to pull it this way. Typically they let you do 6 months of chemo, they fail, and then they’ll do genomic testing. But once I understood that could predict treatment efficacy, I was willing to do whatever it took so I could get that data as fast as I could and have that early in my process.

Dr. Weitz: Unfortunately, the reason why you were forced to get this traditional chemo first, it has to do with the attempt by the healthcare system, by the insurance companies, to spend the least amount of money possible and, taking traditional chemo is less expensive than immunotherapy and unfortunately that’s a factor.

Julie Stevens: It sure is, but you know what else is a factor? how your doctor is compensated. And unlike almost any other drug on the planet, your [00:20:00] oncologist is compensated based on the number of chemotherapy sessions administered. So it’s important to understand this is, and if they want to do something that is not the standard of care, the amount of paperwork and challenges and meetings they have to go through to get that approved, it’s not a small task.  So you want to find an oncologist that is a maverick, that is willing to think outside of the box and challenge those assumptions? It took me an army to get this done, but it is worth your energy.

Dr. Weitz: Yes, sometimes you have to swim upstream in the healthcare system to get the care you really need.

Julie Stevens: It’s true.  And you are your best advocate. Nobody cares about you like you do. But I knew the squeaky wheel got the oil. That’s true in everything we do. But I also knew the squeaky wheel that was positive and not a pain in the butt got better oil. So again, by throwing these parties and bringing stickers to everyone and postcards and showing my appreciation for everyone there, I got what we call incremental [00:21:00] effort from every single healthcare professional, whether it was the front desk person, whether it was a nurse, whether it was my oncologist, they all spent a little extra time with me, or came by to see me, or checked in with me, or checked in with me after my session.

So by bringing the best of who I was to these sessions, I got the best of my healthcare team as well. And I would encourage anyone listening to really think about, don’t bring sticks, bring carrots, and get them to really engage in your story.

Dr. Weitz: What was the particular genetic test that you utilized?

Julie Stevens: I used the neogenomics.  So that was, sorry Secretary, that was the specific genomic test. The genetic test I used was just through my hospital system, and they did the standard, yeah. Yeah,

Dr. Weitz: I meant the genomic test, the cancer characteristics, yeah.

Julie Stevens: Perfect yeah. So I used Neogenomics and that was really important to me. I actually had two different, I was switching oncologists at the time, so I had both of them pull, so I had Keras and Neogenomics, so I was able to compare what we thought were the two very best genomic providers out there.  It was almost the same data, but Neogenomics gave you a few extra factors. [00:22:00] And one of those To go back to your earlier question about how I change my diet, this is an interesting one. So my herbalist did mention, listen, if you’re HER2 positive cancer and olives are natural indicator of, or not indicator, but natural reducer of HER2 positive cancers.

So while I hate olives, I’m willing to eat eight olives a day if that’s what I need to do to keep my body cancer free because this is a HER2 positive cancer and olives can help reduce HER2 positive cancers. So those are the sorts of things that when you understand it, you can actually feed your body the tools it needs to repair itself.  Same thing with kiwi. Kiwi actually repairs your DNA. I had no idea until I got on this journey, but so now I’m willing to eat two kiwis a day. It’s easy when you feed your body the right things.

Dr. Weitz: I don’t think most people are aware of that. There’s data to show that kiwi repairs your DNA.

Julie Stevens: That’s exactly right. I have a podcast as well, so I have an episode with a person named Peter Broadhead, who was an herbalist, he had a nutrition store, he’s had all sorts of different environments worlds. And he came on and gave us [00:23:00] some really beautiful data about the types of foods you need to eat, so things like mushrooms, kiwi, etc., that can really impact your health outcomes. Yeah,

Dr. Weitz: mushrooms we know for their immune strengthening properties, the mucopolysaccharides. Thank you. In terms of you mentioned a few things what are some of the other ways that people can decrease some of the side effects of traditional cancer care like chemo and radiation?

Julie Stevens: Well, I’m going to say this. I actually built a tool. So it’s all available on our website for free. So you can go on and put in what chemotherapy you’re taking or any side effect of any medicine and understand the supplements, the diet, the lifestyle, or the healers you could use to avoid that side effect.

And so your question might be, how did I collect this data? Again, I’m an industrial psychologist by trade. So I understood how to build the formula and the protocol for how to do this. Then I went out and worked with experts around the globe to get the feedback on what would you do if, what can a chiropractor impact from a side effect perspective?

What can an acupuncturist impact? So I went out to each of these specialties [00:24:00] to understand what the opportunity was and did surveys to experts in those areas. So I got their feedback and then I used a number of different practitioners to help me build the list of what these supplements could be to avoid these side effects.

Come to find out, and this is one of the things that my team taught me. is if you start chemotherapy and your body’s idling at an 8, you’re going to drop to a 6 and you’re never really going to feel it. But if you start chemotherapy and you’re at a 5, and you drop to a 2, you’re on death’s doorstep.

So make sure you start these treatments as strong as you physically can be, so that when you take the hit, it’s no big deal. And so that’s part of it is, beyond everything, make sure your overall health is as strong as possible. That means staying Sleep and meditation and giving your body a rest before you start treatment.

I was walking. I literally have walked and exercised more than I ever have since I’ve been in treatment, knowing how important that was, not only from a health and wellness perspective, but for example, that helps express your lymph nodes. And for me, that was really important. [00:25:00]

Dr. Weitz: Yeah. Absolutely. I think a lot of times patients going through traditional cancer therapy like chemo feel like crap and don’t have a lot of energy.  So they tend to avoid exercise and conserve their energy.

Julie Stevens: And that’s the whole point. You, your body needs the right fuel to have energy. There was never a day, besides when I was in surgery, so let me say that, once I was healed from surgery, there was never a day when I was in treatment that I wasn’t strong enough to go to work, to go out for a walk, to make my own food.

I never had a day where I wasn’t well enough, but that was because I had done all the preparation work to make sure my body would sail. And so you’re either going to pay for it before or after. When you pay for it before, it’s a lot more enjoyable for the way you live your life.

Dr. Weitz: Yeah, you’re mentioning another concept, which is one of your principles that you mentioned, which is that when you have a diagnosis of cancer, all [00:26:00] the treatment is focused on trying to kill the cancer.

And yet, the health of the host is super important, as you’re mentioning, if you go in at a level 5 instead of a level 8, your ability to even handle the treatment is going to be greatly diminished there needs to be equal or, equal amount of focus on making sure you, your body, your health overall, I don’t know, is at a highest level possible, that you have good energy, that your blood flow is good, that your immune system is good, all these things that are going to play a secondary role in helping you to fight the cancer, survive, and also make sure you don’t die from something else.

Julie Stevens: That, so that was kind of the big thing that was a takeaway for me, is, your, is, and again, I’m using my industrial psychology brain, your oncologist job is to reduce cancer cells, it is not to make you live a long and happy life 15 years after treatment, [00:27:00] so they’re really focused on one, one microscope, and when you understand that microscope, you want them to do that, But you also need support so that you, that doesn’t kill you.

So things like when you think about certain types of radiation, that’s cool that you don’t have cancer anymore. You just died from radiation or you had this horrible chemo. I just talked to someone who was a a saxophonist for one of my favorite bands and he was diagnosed with the exact same genomic type of cancer.

And I talked to his wife. A couple weeks before he died, he had gone through the standard of care where it was one chemo, a more intense chemo the third hardest chemo. That chemo is what killed him. It wasn’t the cancer.

Dr. Weitz: Yeah, it’s sad. You mentioned six toolbox to build your strategy. Maybe you could summarize what are those six toolboxes that are important in your Cancering journey?

Julie Stevens: Yes, can I give a, I’ll give a really fast history lesson too.

Dr. Weitz: Sure.

Julie Stevens: One, you think your doctor is trained on all these things. So again, using [00:28:00] my history, I went back and studied medical school curriculum because I believe we can only hold our doctors accountable for what they know and the data they have access to.

So when I’m back, but went back and studied medical school curriculum, I understood the little that they knew about six toolboxes. So I consider the six toolboxes Pharmaceuticals, Botanicals, Nutraceuticals, Diet and Lifestyle, Environment, and Facilitated Healers. In their curriculum, is pharmaceuticals. And when I went back to understand why, it was because of something in the 1909 that was published called the Flexner Report.

So many of you might be familiar with the Flexner Report, but that’s basically where they went out to have some continuity of medical school curriculum. And in that, if you taught acupuncture, or herbalism, or chiropractic as part of your medical school curriculum, You lost funding. So in 1910, our doctors went from being jacks of all trade to masters of pharmacology.

So it’s really important to understand it’s a really valuable toolbox, but it is one toolbox and it’s up to [00:29:00] you to get your botanicals, nutraceuticals, diet and lifestyle environment and healers in line to heal everything else.

Dr. Weitz: Yeah, it’s absolutely the case that traditional medical doctors know little or nothing about nutrition, herbs, alternative care.  They’re basically taught that those things are not super important. Yeah, nutrition matters somewhat. So, don’t eat a couple of foods and that’s about it.

Julie Stevens: Don’t eat lunch meat, don’t eat sausage, don’t eat bacon, and don’t eat meat, or what they told me, but the reality is that’s so far away from the reality of how I can make my body thrive.  And when I understood that, I was like, cool, this is your box, but it was important to note, It’s not that they didn’t tell me not to take the herbs. It’s not that they didn’t tell me to do the, to eat the food. They told me, hey no, you shouldn’t do this.

Dr. Weitz: Oh, a hundred percent. In fact, those herbs are unproven.  They contain [00:30:00] antioxidants that can counter your treatment.

Julie Stevens: So I was strong enough to push back and say, if you can show me one research article that this is true versus your fear of how it’ll impact, I will stop right away. And they couldn’t come up with one research article. So I was like, cool, this is my body, what I do outside of your office, you’re responsible for cancer cells, I’m responsible for my body, you keep working on my cancer cells, I’ll keep working on my body.

But I don’t think most people are that bold.

Dr. Weitz: Right, yeah, this has been a discussion that comes up over and over again, every time we have a discussion about cancer is it’s known that traditional chemo and radiation, that One of the things that happens in the way that they kill cancer cells is by creating free radicals in the body.  So therefore, anything that contains antioxidants like vitamin C or vitamin E or any of these other antioxidants are therefore going to uncouple the chemotherapy. And yet, [00:31:00] many studies show that the more vegetables and fruits. that you eat, the more likely you are to beat the cancer, the less likely you are to get cancer.  And those are containing huge amounts of antioxidants. So it’s never really made sense.

Julie Stevens: Also, again, I’m a data girl. So let’s just say that when you look at this, your doctors, the data set they have to make decisions is disgusting. So I’ll give you a perfect example. There is one study of people who have been successful.  Like I have been. on, on, on immunotherapy with colon cancer. There’s one study. There’s not a study if they, if, what if you stop at 18 months? That data doesn’t exist. What if you do this drug for four years? It doesn’t exist. There’s one study that if you do it for two years, here’s the outcomes you can expect to achieve.

So when you’re listening to your doctor, actually look at the research they’re referencing. Understand this, the limited scope of the data they have to predict outcomes. Efficacy. It is not what you think, where they would understand, listen, if I stop at 18 months, here’s the reality of [00:32:00] your outcomes. No, they’re using the best guess based on the limited data they have, which is all we can hold them accountable for.

But the data is lacking because most companies only need data to get FDA approval, not to actually prove how to optimize the drugs so you live your best life. And that’s a different approach.

Dr. Weitz: There’s a lot of issues around data. We could talk for hours about it, but one thing to keep in mind is to conduct a randomized double blind placebo controlled trial on anything other than a drug, of course is very difficult. So, to try to run a study like that on a food, when nobody’s gonna benefit from potentially making billions of dollars from eating pomegranates or broccoli or whatever it is nobody’s gonna want to fund that study. So, those studies are not done, and we have limited data from these food frequency questionnaires, which are [00:33:00] completely inaccurate, and so we just don’t have comparable studies on Common Herbs Fruits and Vegetables many of the lifestyle factors because there’s no funding mechanism for that other than the NIH which is basically doing some of the basic research to help the pharmaceutical companies develop their drugs and

Julie Stevens: I would say yet.  I agree with you, but the answer I would say is yet. And that is why I started this non profit, Mojo Health Exist, to build the data set. Because I know my doctors have continuously said, we’ve got your data, and I’m like, you have a core of the data of what I actually did to heal this. So I know the reality is of what you did, you’re just giving credit to the pharmaceutical.

But much more went into my story than just that one drug. And so Mojo Health Exist, because I believe you’re absolutely correct. No one company is going to pay to understand the interplay of how all these things impact health outcomes. So this needs to be based on a [00:34:00] patient led revolution, and that is what I’m leading.

I want to invite patients to join together with me, so we build the data set on what we are doing, so this might not be a double blind placebo, but I can give you a correlation study to understand, listen, people who have your genomic type of cancer in Chile do this, and in Turkey they do this, and in Japan they do this, and the U.

  1. they do this, and here’s the difference in outcomes. And when we can drive people to understand how the globe heals differently, and what options can give them the optimal outcomes, and what interplay of options really helps that’s how we can change cancer. We take this out of the corporation’s hands, and we put it in the patient’s power.

Dr. Weitz: That’s great. You’ve mentioned already about using cancer biomarkers, blood biomarkers to track what’s happening with cancer. Maybe as opposed to when your oncologist told you that you would do six months of chemo and then get a PET scan to see what happened. And [00:35:00] you distinguish between the fact that the PET scan is a lagging indicator versus some of these biomarkers that can help you identify what’s going on right now. Which are you progressing? Are you regressing? Is can you talk more about some of those most important biomarkers?

Julie Stevens: Yeah, so, there’s a couple different types of biomarkers you can look at in your blood. And I think the, this is like measuring how many invitations were sent to the party.  So you understand how big is this party? What’s happening with my cancer? So when I understood the proteins that were being developed as a result of the cancer, and if those proteins are going up, You have more cancer activity. And if they’re going down, you have less cancer activity. So the first thing I looked at was something called CA 19-9.  That’s a blood marker that’s traditionally used for pancreatic cancer, but it can also be a good indicator for colon cancer as well. This is not something that’s used around the globe. It’s only used in a few countries. So it’s one of those things that my doctor said, Hey, I don’t follow that. I think you’re fine.  You’re not chemo resistant. [00:36:00] When I came back and said, Hey, I’m chemo resistant. Cause let’s be real. That was a 30 blood test that I was doing outside of my doctor. I did that on my own. I tracked and it was going up after my second chemo administration. So I texted my doctor and said, Hey, listen, I’m chemo resistant.

I’m not coming back for chemo three. And he’s like, Julie, I’m the expert. Trust me. That’s not a data point we follow. And I was like, these six industrialized countries follow this. So this is what I follow. So you need to pull data to disprove my theory in order for me to come back. Again, I don’t think most patients are quite that bold, but he, so he did two tests.  One is a PET scan and the other was CT DNA. which most of your listeners might know, but for those that don’t know, that’s looking for tiny broken particles of cancer. You’re circulating tumor DNA. And so the reality is we don’t want to use one of these tests to make a huge treatment decisions. We want to use a lot of different data points, looking at different aspects of the cancer to drive our treatment strategy.

So would I have made this decision on CA 19-9 alone? No. Was it a great indicator that we needed to collect more data? Yes. And [00:37:00] the idea here is we want to collect as much data as you can. before you start treatment. And I think that’s a really important thing. Doctors don’t tell you, hey, this tumor is not urgent.

They don’t tell you that. And as soon as you’re told you have cancer, you think, I want this out of my body as fast as we can. But the reality is my cancer was growing for over 10 years. I had a month to stop, collect my data, get all my baseline information, build my team, build my body, take the time to do that, because then the way you ride is much smoother versus jumping into treatment, and you’re like, and then you’re already knocked down a few pegs.  So I just wanted to mention that urgency thing is really important and to get all that baseline data so you can measure the score of the cancer early on and know when you need to fail and pivot.

Dr. Weitz: Right. I was reading that Your herbalist acupuncturist was also looking at things like zinc and copper and CRP and inflammation levels and things like that.  And some of these markers indicate what’s [00:38:00] happening in the body that is gonna change the terrain that the cancer is growing in.

Julie Stevens: That’s exactly right. His biggest focus was, are you going to have a blood clot? Because you’re going to die way faster than the blood clot than the cancer. So let’s make sure your blood’s in great order.  Your neutrophil and lymphocytes are in line. Like, let’s look below that first level to understand really what the score is of the health of your body and the health of your terrain. So it’s not just one, it’s really all of it.

Dr. Weitz: Right. And most cancer patients are going to die from heart disease despite the cancer.  So you don’t want to beat the cancer and die of heart disease.

Julie Stevens: Which that’s, when I understood, I was a little angry when I learned this fact, that most cancers are a metabolic disease. And in fact, if you keep your body in line, you will not only not have any heart tumor cancer, you won’t have heart disease.  So why don’t, why didn’t I know that until I dug into this world? That to me is such an important fact for everyone to understand. You can avoid heart [00:39:00] attacks.

Dr. Weitz: Yep. And that’s called the Metabolic Theory of Cancer.

Julie Stevens: Yeah.

Dr. Weitz: And that’s something a lot of people in this space have been talking a lot about, including Thomas Seyfried and Nisha Winters.

Julie Stevens: Nasha Winters was the book where, I mean, my herbalist said this, and he is a friend of Nisha’s, so he talked about her, and I was like, I don’t believe you. And so I had to go do my own research, and after talking to so many doctors and going to conferences and reading these books, I was like, I believe you and not only do I believe you, I want to shout it from the rooftops because I know we can create a body that’s inhospitable to cancer.  And if given the opportunity, we need to prove exactly what we need to do to do that because everyone who’s had cancer will do that to not have a recurrence.

Dr. Weitz: Yeah, Nasha had a diagnosis similar to yours. She had a stage 4 ovarian cancer and basically was left to die and probably the fact that she felt so horrible and couldn’t eat and end up fasting for close to a month is probably what [00:40:00] helped her body fight the cancer.

Julie Stevens: For sure.

Dr. Weitz: So let’s bring this to a close. Let’s finish on the topic of trying to find joy in your healing process. And then tell us about your contacts.

Julie Stevens: Yeah, so, I think, one of the most things, the best things you can do for your body is to not live in fear, as I mentioned, and so I worked really hard to use joy.  So as I mentioned, I dress up in costume, I bring gift bags, but it’s more than that. It’s I look at every single day and realize what I’m grateful for. I start every morning by focusing there, not on the fact that I had to fight cancer. I never once looked at that as a cross to bear. That’s an invitation to change.

Right. And you reframe your thinking as, okay, the world’s got to change. Like my world is not the same as it was yesterday. Things are different. I’m willing to accept this change. I’m willing to take on the change and do what I need to do. It wasn’t a hardship. My life is better and I’m happier [00:41:00] post cancer diagnosis.

Dr. Weitz: Nasha Winters often talks about instead of fighting cancer, cancering, and how you’re basically going through this journey.

Julie Stevens: It is not a death sentence. It is a life sentence though.

Dr. Weitz: That’s great. So how can listeners find out more about your program? You have a podcast, you have this website with helping cancer patients figure out how to work their way through this process.

Julie Stevens: Yeah, so I basically, as soon as I was declared no evidence of disease, I made a list of all of the reasons why cancer sucks. And I have one by one tried to systemically answer those reasons. So it started with I wrote a book so that you would understand how to build your team. And then it started with, wait, we can do better than this.

Actually, I’m going to write a job description so that you understand what your role as a patient is. Okay wait. Now I’m going to write tools so that you understand how to select a doctor and how to build this team. Now we went forward to, as I was working with my herbalist in this team, I was like, Guys, we [00:42:00] can build this so that anyone can go and figure out how to avoid side effects online.

So, that is all available for free on MojoHealth. org. Mojo Health, which stands for More Joy. Because that’s why every joy comes back to everything. So mojohealth. org is the place where you can go and we have built all sorts of resources. I just launched a what now guide for newly diagnosed so it’ll walk you through the very first questions you should be asking, the types of data you can really start to gather to change your strategy, how you can build your team so it walks you through step by step.

But we’re also just about to launch a what now guide for caregivers because we want to help people understand how they can gift better. And so this is one of the things I would mention is just this week one of the challenges I’ve faced and let’s be real, very little of what I did to save my life was covered by insurance.

I’m facing financial devastation as a result of saving my life and no one should have to face thousands and thousands of dollars in debt despite the fact that I have a wonderful job and a healthy savings account. All of that is gone because [00:43:00] this is, these are the reasons why you have a healthy savings account.

So one of the tools we’re building is a registry so you can go on there and build your strategy and share that with your network and someone else can buy you a bottle of magnesium or vitamin D instead of a coloring book or a Or dropping off lasagna or flowers that dies. So let’s actually teach people how to help you with what you need.

So I am just taking this off one list at one, one challenge at a time. And you’ll see that in my podcast. We’ve done podcasts, everything from how to have financial wellness after diagnosis to how to prepare. So you don’t lose your hair with capping. to most recently we just did one on how to prepare your body for radiation.

So we are talking with experts around the field, just all about cancer, the stuff that isn’t what your doctor teaches you, but really can change your game. So we’re going to not stop until I’m in the grave, because I know from what I know that we can have, we can make cancer suck less, only if we work together and share the best practices and tips that each one of us share and that one on one level to a [00:44:00] much broader audience.

Dr. Weitz: We can make cancer suck less only if we work together.

Julie Stevens: That’s exactly right. Hence the name of my podcast is Mojo Rising, How to Make Cancer Suck Less,

Dr. Weitz: thank you so much, Julie.

Julie Stevens: So grateful to be part of this and thank you so much for helping me spread Mojo with the world.

 


 

Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast.  For those of you who enjoy Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues, like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive [00:45:00] health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition Office at 310-395-3111. And we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

 

Dr. Trent Orfanos discusses Integrative Cardiology with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

1:33  Functional Medicine.  Dr. Orfanos was a conventional, interventional cardiologist. He has a daughter with cerebral palsy and he and his wife took a Functional Medicine approach to her health, using nutrition, supplements, exercises, and patterning. She went from unable to crawl to walking on her own. But he continued to practice conventional cardiology until 2010 when he was looking for a wellness program for hid cardiology practice and he went to a meeting on supplements and it was a real epiphany for him and he started applying it and his patients got better and healthier.  He was convinced.

3:06  The Mediterranean Diet.  Dr. Orfanos believes in the Mediterranean diet, which is one of the most well-studied diet and it includes fruits and vegetables, nuts and seeds, fish, and some meat. It also includes plenty of olive oil and legumes. He is also comfortable using olive oil to cook with and he points out that he is Greek and the Greeks have been using olive oil to cook and fry with for millennia.

 



Dr. Trent Orfanos is the Director of Integrative and Functional Cardiology at Case Integrative Health in Chicago, Illinois. Dr. Orfanos practices invasive interventional cardiology from 1982 to 2019 but he embraced preventative cardiology from the functional Medicine perspective starting in 2010 and exclusively from 2019.  Dr. Orfanos has board certifications in Internal Medicine, Cardiology, Integrative Medicine, Functional Medicine, and Anti-aging Medicine.  He is also an associate clinical professor of medicine at the Indiana University School of Medicine. His website is caseintegrativehealth.com/cardio.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

 

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, drweitz. com. Thanks for joining me and let’s jump into the podcast.

Hello, Rational Wellness podcasters. Today, we’ll be having a discussion on integrative cardiology with integrative cardiologist, Dr. Trent Orfanos. Dr. Trent Orfanos is a director of integrative and functional cardiology at Case Integrative Health in Chicago, Illinois.  He practiced invasive interventional cardiology from 1982 to 2019, but he embraced preventative cardiology with a functional medicine perspective starting in 2010 and exclusively from 2019. Dr. Orfanos has board certifications in internal medicine, cardiology, Integrative medicine, functional medicine, and anti aging medicine.  He’s also an Associate Clinical Professor of Medicine at the Indiana School of Medicine. Thank you, Dr. Orfanos for joining us today.

Dr. Orfanos: Well, thank you for having me on. It’s great to be here.

Dr. Weitz: So maybe we can start with the transformation in your career. How did you decide to move from the dark side into the light?

Dr. Orfanos: Well, you know, the once you see the light, it’s hard to go back.  And so I can say that my story, excuse me, my story goes back. I have a daughter that’s I have four daughters, so I’m blessed. And the first one was born with cerebral palsy, which is a brain injury. She couldn’t walk or crawl even up until the time she was three. And we adopted what turned out to be a functional medicine approach to her health, not knowing what it was called. And it’s a lot of patterning, exercises, nutrition, supplements. She went from unable to crawl to like walking on her own, which astounded her doctors who didn’t expect it.  So that was a first aha moment. And

Dr. Weitz: That’s great to hear stories like that.

Dr. Orfanos: Wonderful. And so that was, she was, she’s now 43. And and then 2010, I. I was looking for a wellness program for my cardiology practice and I went to a meeting on supplements because I thought that I wanted to know more about them.  And it was just a real epiphany for me and it all came together.  It took a while but and I started applying it.  Patients just got better and healthier and they weren’t getting healthier before and now they are.  So I was convinced.

Dr. Weitz: That’s great. So maybe we should start with diet.  So what are your thoughts on a heart healthy diet? 

Dr. Orfanos: Sure my my background’s Greek; all my grandparents were from the old country.  And so the Mediterranean diet is probably one of the most well studied diets in the world. And it basically that’s, so that’s one of my favorite ways to recommend eating.  It’s not low fat. There’s plenty of olive oil and some animal fats in there too. Fruits and vegetables, nuts and seeds, fish. It’s and that encompasses so many healthy phytonutrients that are in there. It’s and it translates into less fat. Heart disease, less dementia, less diabetes longer life expectancy.  It just pays off all the way around.

Dr. Weitz: I liked the Mediterranean diet, but I will say that when you look at the studies, there’s a little squishiness around the edges, like one study will say it includes legumes. Another one will say it includes cheese or eggs. Another one will say it includes bread.  And there’s a little vagueness there.

Dr. Orfanos: Yeah. Yeah. And that just to me, that just [00:04:00] goes to show you that, you gotta be flexible, in your diet that growing up with this being just inherently part of my life, I never experienced like some people didn’t need legumes and some did, they all did.  They were all, we had, bean soup on Sundays.  But it was like a routine thing. I’d say it includes all of those things. I know carbs and bread and gluten are sometimes get a bad rap, in, in the, when you wrap it around that whole high olive oil, polyphenol diet, those things seem to be like be okay.

Dr. Weitz: Right. What about saturated fat? It’s been popular for the last number of years in the functional medicine world. There have been some prominent books that have come out saying that saturated fat, butter, egg, cheese, etc. don’t really contribute to heart disease, that it’s not really saturated fat, the real problem is sugar.  What do you think about that?

Dr. Orfanos: I think probably back in the, what, in the sixties, I think the speaking of that kind of thing, the seven, yeah,

Dr. Weitz: Those big studies and those studies have been criticized and

Dr. Orfanos: I’m more on the side of, saturated fat in and of itself is not bad. You’re eating in the context of.  Of these healthy animals were raised healthy. You’re eating it with olive oil and and, boiled greens sprinkled with olive oil and lemon juice. And

Dr. Weitz: And this kind of, in other words, eating some grass fed meat or some organic chicken that has saturated fat is not really a problem because it’s in the context of a healthy diet with olive oil and these other healthy fats.

Dr. Orfanos: That’s the way I see it. It’s a holistic approach. It’s everything that you’re doing that’s going to make you better. It’s hard to isolate. I’m just going to have some saturated fat today by itself.

Dr. Weitz: But people do have questions like, What should I be using to cook my eggs in? Should I use butter? Should I use coconut [00:06:00] oil? Should I use, olive oil? Should I use avocado oil?

Dr. Orfanos: I can tell you that even though you get this, Oh, don’t fry things in olive oil because the olive oil gets ruined by doing that we Greeks have been frying things in olive oil for millennia.  And I just can’t, I don’t buy that, that I understand what you’re saying. It gets maybe trans fatty or whatever, but that’s just, isn’t the way people live. Okay. They use olive oil for everything. They don’t go out and buy avocado oil or coconut oil. They use olive oil for everything. And they do pretty well.  There’s blue zones in Greece,

Dr. Weitz:  What about coconut oil?  Is coconut oil a healthy oil?

Dr. Orfanos:  I think you can use coconut oil for high heat situations. It is, of course, a saturated fat, but I think it, I feel like it’s okay to use it. I wouldn’t like make that your exclusive fat, right?  I think olive oil is probably where I’d like it to go. Maybe avocado oil. If I had,

Dr. Weitz: I know myself, I switched to coconut oil for a while for high heat cooking for like when we bake vegetables. And when I started using it consistently, my small, dense LDL started to go up and my LDL particle numbers started to go up.  So I switched over to avocado oil for high heat cooking. And then I use olive oil for lower heat cooking.

Dr. Orfanos: I think that sounds really wise.  And some people that may have, you’ve probably heard of the APOE genotype. If you’ve got the E4, you probably should go low fat, low saturated fat, because those people respond like that. They, their LDLs and particles go up too high.

Dr. Weitz: Okay. When let’s go into testing. When we take more of a functional integrative approach and we’re trying to assess the cardiovascular system usually we want to do more detailed testing than a standard lipid profile.

Dr. Orfanos: Yes. I, I routinely do advanced lipid panel testing. So what is that? So beyond the usual LDL cholesterol total triglycerides and HT l we do we look at the lip, the LDL particle number. So LDL cholesterol is gets the name bad cholesterol, but depends if it. If it’s oxidized or not.  So we look at how many particles there are in there, the more particles, the more risky it is. We look at the size of those particles, so small particles are more dangerous. So big particles are like beach balls bouncing around inside your arteries. They don’t cause much damage, but small ones are, they’re like golf balls, They can hurt, when they hit the walls.  And that’s relatively what the way I like to think about it. We’re looking for beach balls instead of golf balls. And we want them, we want, we look at inflammation markers too. And we want to make sure that everything is

Dr. Weitz: What are your favorite inflammation markers?

Dr. Orfanos: High sensitivity C reactive protein is like pretty universal. It’s not specific, but, if that’s high, that goes along with all kinds of risk for bodily chronic disease you can imagine. 

Dr. Weitz: Right.

Dr. Orfanos: There’s oxidized LDL, ox LDL, that’s the hot inflamed golf ball LDLs. And there’s a Lp(a), Lp(a), the one that’s that you can check. And if that’s up, that implies inflammation actually within the vessel wall.  And then you do things that are common to lower inflammation. And a lot of it circles around the foods that we eat, like the Mediterranean diet, that’ll bring those down.

Dr. Weitz: And what other components of testing are included?  Do you, are you running like homocysteine levels?

Dr. Orfanos: Yep, I routinely run homocysteine levels.  I’ll check hemoglobin A1c, which is a marker of how high your sugars have been for three months. And fasting insulin levels. I’ll check uric acid because it’s a risk factor too.

Dr. Weitz: Yeah. We can thank Dr. Perlmutter for bringing that on the radar screen as a metabolic marker.

Dr. Orfanos: Yeah. He’s, I really appreciate that he brought that up.  I check the RBC levels of omega 3 fatty acids or fish oil. That’s, if there’s one thing you can do. If your Omega 3 Index, your RBC Omega 3 Index, that’s DHA and EPA, if that’s at the highest levels, at 8 percent or more, compared to those, most of us running around at 4 ish or so.  When you’re up here, there’s less death from any, from all causes. That’s death from heart disease and cancer.

Dr. Weitz: Yeah, I try to target above 10 if I can.

Dr. Orfanos: Oh, that’s tremendous, yeah, if you can get up that high. If you’ve got the E4 genotype, Dr. Bredesen’s Alzheimer’s guy says, It 10 percent your goal, but if you can get it a 10 fine.

Dr. Weitz: What do you think about HDL? For a while was considered super important High HDL was supposed to be protective and I would say in the last five years the importance of LDL has been somewhat called [00:11:00] into question and then we now see that high HDL above 80 is actually often considered to be non functional and actually not good.  And so we’re trying to assess more HDL functionality these days, but it’s hard to assess that.

Dr. Orfanos: Yes, you can do myeloperoxidase, which is a sort of a surrogate marker for dysfunctional HDL. So that’s something that can be done. Also it’s if you’re making a lot of HDL, I heard somebody’s HDL was like, I had this one patient of mine.  She was an elderly woman. Here, HDLs were like, 110 and she was, she had terrible vascular disease. Your body’s making more of a dysfunctional that doesn’t an HCL doesn’t work. So it just keeps pumping out more trying to make up for it. And it’s a sign of, like you say, dysfunctional HCL that don’t, that doesn’t work.

Dr. Weitz: What do you think about TMAO? 

Dr. Orfanos: Oh, that’s a, yeah that’s a tough one because TMAO goes up with eating fish, for instance. So I’m like, I’m thinking, wait a minute, if you eat fish, you’ve got less heart disease. I’m more with eat the healthy diet. It should contain fish.  And I don’t say ignore the TMAO, but to me that’s. I’m going to say, maybe it’s heresy, but I’d say that’s secondary to, to the healthy diet idea.

Dr. Weitz: When you look at the data on TMAO, a lot of it’s dependent upon the gut microbiome. And I’ve had I was running TMAO regularly for a while and a lot of patients, if they had a healthy gut, Would have a normal TMAO no matter how much fish or meat they were eating.  So I think it might be a marker for an unhealthy gut more so than really for cardiovascular disease.

Dr. Orfanos: And that sounds like the old functional medicine axiom, start with the gut.

Dr. Weitz: [00:13:00] Exactly.

Dr. Orfanos: Somebody just go for their gut and get that working good. And the other things fall in line.

Dr. Weitz: So if we discuss some of these markers that you see tell me, what are some of your favorite strategies to address?  So for example what’s the first thing you think about doing for a patient who has an elevation of LDL particle number? And if they have a lot of small dense LDL.

Dr. Orfanos: Okay. Usually it starts, it starts with food. So those people are, generally eating a high carb, high sugar, inflammatory food type diet.  And you need to start turning that around. It’s hard to change people’s food. They’re very much attached. We all are. We’re attached to what we like, so we don’t want to change. But if you can eat low carb Mediterranean you’re going to, and perhaps do some intermittent fasting, which I think is overall a good idea.

That can turn around just with that. And then things like omega 3 fish oil they’ll flip that too. [00:14:00] You’ll get your particles, number goes down, your particle size goes up, your HDL goes up, inflammation comes down. It’s just a win. Those are good. I’ll use I’ll use some I’ll sometimes use berberine as far as berberine is insulin sensitizing and lowers LDL cholesterol.  It’s It works like these shots called PCSK9 inhibitors. It’s got that kind of function.  That’s cool.

Dr. Weitz: It’s one of the few things that’s been shown to reverse plaque.

Dr. Orfanos: I didn’t, I’m not sure about that. Did you see that?

Dr. Weitz: Yeah. Yeah. There’s at least one or two studies showing that I’ll send them to you.

Dr. Orfanos: Okay, that’ll be great. I’d like to see that. There’s there’s other there’s another supplement out there that’s made that, that comes from seaweed. This is secondary but actually it’s pretty good. That can actually reduce plaque and especially the vulnerable.

Dr. Weitz: You talking about like the Arteriosil

Dr. Orfanos: yeah, Arteriosil. Yeah. I think that’s amazing. Yeah. Endothelial function. Function and glycocalyx. The linings of the artery. Yes. All that gets [00:15:00] better. We forget about, there’s strategies to try to heal all that, which is gonna help that artery work better. Of course you gotta get your lifestyle right.  You got to be eating right, you got to be exercising, you got to be sleeping correctly. You got to watch your stress. You can’t be walking around, wired and angry and all that all day long because that’s going to, that could distort everything you’re trying to do. What else can I tell you?

Dr. Weitz: Let’s see. What if you have small dense LDL? How do we make that LDL particles larger?

Dr. Orfanos: Those will change all those strategies I mentioned, they that’ll flip that the LDL particles will become bigger, fluffier and less dense.

Dr. Weitz: Okay. So you mentioned some supplements, any other supplements you use for LDL?  Do you use red yeast rice?

Dr. Orfanos: I use red yeast rice. That’s one of the more effective ones because it, as it contains a statin, basically, that’s where they found it. Those monoclones are where they purified the statin. They took it out, purified it, made a drug out of [00:16:00] it. So those, that works pretty good.  You gotta use enough, but you can get LDLs down.

Dr. Weitz: Yeah. You got to use at least 2, 400 milligrams.

Dr. Orfanos: Yeah. Yeah. You can go up to 4, 800 if you need to.

Dr. Weitz: Yeah, exactly. Citrus bergamot. Have you used that one?

Dr. Orfanos: I don’t use much of that. Doesn’t seem all that effective. I think Red Yeast Rice has got an edge, got a, it’s better.  It’s better.

Dr. Weitz: Yeah. Yeah. I definitely think on the supplement side, Red Yeast Rice is one of one of the supplements that’ll move the needle the most, or the supplement that’ll move the needle the most.

Dr. Orfanos: For LDL, sometimes you can use like Annatto E it’s gamma delta tocotrienols. Those will do it too.

Dr. Weitz: Yes. Yeah. I’m a big fan of those. Dr. Bertie Tan, we’ve had him on the podcast a couple of times.

Dr. Orfanos: He’s wonderful. He’s great.  Real kind guy too. Yeah. So that’ll work.

Dr. Weitz: And then when do you use medications?

Dr. Orfanos: If I have people that come in and they’ve got [00:17:00] established coronary disease, I had a lady come in today and she’s got, she just had a heart attack in February and she’s got a stent in the very heavily calcified coronary artery. I said, I, this is where statins, this is where pharmacology, the benefits outweigh the risks. If you’re a 40 year old guy with a cholesterol of 230 and somebody puts you on a statin and there’s nothing else going on, I don’t think that’s, the payoff is pretty small there.  But for her, the payoff I felt was good. So I put her on a low dose of the statin.

Dr. Weitz: Which, which statins do you prefer the most?

Dr. Orfanos: I like Crestor or Resuvastatin. It’s Pretty potent. It’s one of the more potent ones as far as Statins go. It it’s got a pretty long half life, so you could use it like, three times a week instead of every day, if you’re people are having trouble with it and still you get pretty good results.  And it’s water soluble, now that’s arguable, but that may, it may be less side effects with the water soluble ones than the fat soluble ones. Yeah,

Dr. Weitz: I know a number of cardiologists who feel that way.

Dr. Orfanos: It’s worth doing. And then they got these new drugs out. I mentioned the berberine like drug, the PCSK9 inhibitors, those are shots that just, all they do is there’s these receptors in the liver that suck out the LDL and when you take the shot, you get more of them they don’t break down, so they persist.  So your LDL comes out. Very few side effects, people get by pretty good with those compared to statins. There’s another one that’s Bempedoic acid, that’s a drug that just works in the liver, seems to have really low side effects and does the job.

Dr. Weitz: Yeah, some doctors I know, some cardiologists who want to use the medication and for patients who don’t tolerate a statin they’ll sometimes use Bempedoic acid and Zetia.

Dr. Orfanos: Zetia, yeah, it’s a combo, they come as a combo, which is nice. So one side. The Bempedoic acid stops the production side, which is what most people concentrate on, but the Zetia stops the absorption side. So you get it from both ends, so you can get a pretty substantial drop with that.

Dr. Weitz: [00:19:00] Right.  Have you run that cholesterol absorption versus production test?

Dr. Orfanos: I haven’t done that.

Dr. Weitz: Yeah.  Boston heart.

Dr. Orfanos: Boston heart does that. I’m not against it. I just haven’t done it. I just try stuff, yeah. I’ll try the statin or slash, or one of the others, and then I’ll add Zetia, and then sometimes you get some profound benefits.

Dr. Weitz: You usually recommend CoQ10 with statins?

Dr. Orfanos: Oh, yeah. So you get, the CoQ10 gets depleted with the statins so does vitamin K2, so does fish oil, so does vitamin D. A lot of things get

Dr. Weitz: Yeah.

Dr. Orfanos: drug nutrient interaction thing. And you want to get that CoQ10, if you can, above three. That’s the goal for a good, for best cardiovascular outcomes.  Okay. I measure those two and see where they’re at and supplement.

Dr. Weitz: So what’s your best strategy for a lipoprotein A, LP little A?

Dr. Orfanos: That’s a tough one. I’ll still use niacin in spite of this Article that kind of was condemning it. Maybe [00:20:00] that’s a strong word.

Dr. Weitz: Why don’t you, why don’t we talk about that article for a minute?  So for those who are not aware, there’s a recent paper in Nature by Dr. Stanley Hazen, and he argues that when we look at niacin consumption. There’s a couple of downstream metabolites, one in particular that he claims might be dangerous.

Dr. Orfanos: Yeah, the 4PY and 2PY, yeah, and those down there, , actually, Dr. Houston sent me an article right when the, some of this niacin stuff came out that just showed the opposite, that people that were put on niacin had better cardiovascular outcomes.

Dr. Weitz: Yes.

Dr. Orfanos: They may say this trumps it, because it’s a more recent article, but I don’t know. I, I’ve been using it for For years for a decade or more, maybe more than that since I was doing conventional cardiology and although I’m just me, I haven’t noticed any ill effects as far as cardiovascular outcomes from using [00:21:00] it.  Think it does so many good things raises a LDL particle size decreases LDL particle number increases HDL and HDL functionality lowers triglycerides. I mean that all that’s. going to pay off. I guess one of the questions is if you’re genetically predisposed to make more of these inflammatory metabolites, maybe you’re at some risk.

Dr. Weitz: But that’s one of the points I think one of the critiques I have of that article that Dr. Houston mentioned when I talked to him, which is that that paper is indicates that only certain genetic subtypes are going to produce those metabolites. And in order to see if those metabolites are really dangerous, I was just reading the article last night.

They tested to see if there was a correlation between 2p y or 4p y and heart attack or stroke or [00:22:00] Other cardiovascular disease and it was really no correlation. So all they have is this in vitro analysis that’s associated with certain inflammatory factors And so I think it’s very weak evidence and especially for a nutrient, niacin, which is commonly found in all these healthy foods.  Yes, it’s in animal products, it’s in salmon, it’s in avocado, it’s in all these healthy foods. And it’s really hard to think that this common B vitamin is potentially dangerous.

Dr. Orfanos: Yeah, I feel the same way. And it’s also difficult to apply these sort of the drug mindset.  How do I test a drug? I test, this one molecule for this one disease, and I see what happens. And then I make broad claims about the drug. Okay, but nutrients are a whole different problem. Animal, they’re, they interact with everything that you’re doing. You’re, the [00:23:00] air you’re breathing the activities you have, the other vitamins and nutrients you’re taking.

So that’s, I don’t think you can draw those kinds of strong conclusions like that. But like you say in vitro and then he brings up like he says in this study niacin didn’t help and maybe even increased risk in another study. So he’s combining them and making a claim that because that other study showed something.  That therefore this this this concept that he had must be true, yeah,

Dr. Weitz: He brings up a couple of old studies that in my mind have already been refuted like eight years ago, but he brings up the HPS thrive study and the HPS thrive study didn’t just use niacin. He used niacin combined with a drug Laparipant.  Yeah, it was a drug developed by Merc and the laparapant was designed to reduce the flushing that some people get with niacin.  Which by the flushing is not harmful. It’s just some people don’t like it and that drug had a bunch of side effects and that study The patients had the side effects that were already attributable to that drug.  And then they said that showed that niacin might have these side effects and wasn’t effective. So that wasn’t a very accurate way to assess the effectiveness of niacin. And we got a bunch of other studies that have shown lots of benefits of niacin.

Dr. Orfanos: Yeah, exactly. And I believe was it thrive or aim high?  I can’t remember what aim high. Yeah.

Dr. Weitz: Aim high. They found that there was no benefit, but if you actually go back and read the study, it significantly lowered LDL. It significantly did all these positive things that we know are associated with increased cardiovascular health.

Dr. Orfanos: And one of them was, I forgot which one, was using a drug that was, the idea was to raise HDL, I believe, if I got that I think it [00:25:00] was to raise HDL, and it turned out to be, have a worse cardiovascular outcome, and then they tied it to niacin.

Dr. Weitz: Yeah, I think that’s that lap, laparapan, yeah.

Dr. Orfanos: Yeah, that one there, so I think. So anyway it’s like guilt by association kind of a thing, niacin, niacin was even combined with what was, what did they call it? There was a drug out that combined niacin and never core.  I think one of the first stands.

Dr. Weitz: Yeah. I think both those studies, HPS thrive, in addition to that laparapan that was included in the HPS thrive, Both of those studies had patients on statins and niacin, and they were testing to see if statin plus niacin was better than statin without niacin.

Dr. Orfanos: So I’ll still use, I still use niacin for people with high LP, little now having said that, those PCSK9 shots like Repatha, they’ll lower LP little A probably by a third, by 30 percent or something like that.  Whereas statins, if anything, they might raise it a little bit, [00:26:00] 10%. They really don’t do anything. And then there’s a new, there’s these new drugs coming out, siRNA drugs that are like, they’ll knock it down 90%. They’re, if they come out, then they’ll, that’ll be the answer for people with LP little a that’s I have a patient who’s serious with sputum.  450 today.

Dr. Weitz: Even yeah it’s interesting. I sometimes talk to primary care doctors and they don’t want to run lipoprotein A. And when I tell them that we should run it, They tell me it’s a genetic factor, so why run it? But lipoprotein A, Lp(a), is typically not being run in most patients, unless they see somebody like yourself or like me, who has a functional medicine approach, because there’s no drug for it.  But once that drug is out, everybody will be running it.

Dr. Orfanos: Everybody will be checking it. Yeah. And, if you know it’s high, to me, to be forewarned is to be forearmed. So if I know you’ve got high LP little a, I’m going to be real aggressive in managing your LDLs [00:27:00] and your other risk factors, because whatever I do, I’m going to blunt the negative effect of that LP little a.

Dr. Weitz: And niacin can get you 30, 40 percent reduction. You can get a little more from from L carnitine, there’s several other agents that can help push it down a little more as well.

Dr. Orfanos: I did, I don’t get that much out of niacin. I may get 20 maybe 30, if I’m lucky.

Dr. Weitz: Okay.

Dr. Orfanos: Then I just, I haven’t checked this out yet, but one of my, I was at a functional medicine meeting and I was talking to Dr.

One of the cardiologists there that probably won’t know, and you may know her, Mimi Guarneri, she’s out on Oh yeah,

Dr. Weitz: yep, I’ve

Dr. Orfanos: met her and talked to her. Talked to her about niacin and she said, oh no, I’m using niacin. And she said also that aronia berry, which is an herb,

Dr. Weitz: What’s it called?

Dr. Orfanos: Aronia berry, A R O N I A.  Can also lower LP little a I didn’t get a chance to research it but be something to look into as another.

Dr. Weitz: Yeah, I want to say [00:28:00] I think ortho molecular has a product that has that in it. Okay, they have some cardiovascular products that they have pioneered in the last few years. Yeah, they’re there.

Dr. Orfanos: They’re stepping up there. That’s good.

Dr. Weitz: All right. I’m do you ever test genetics? Thanks.

Dr. Orfanos: I check I’ll check MTHFR. Okay. To see if they’re methylating or not. And then I’ll, that kind of may or may not, it goes along with homocysteine. Homocysteine is high if the MTHFR is off. So sometimes that’s a clue.

And I’ll check I’ll check APOE4. I’m checking that more now. Why would you check on me? Because, like I say, it’s back to the forewarned, forearmed idea. If I know you got it, I’m going to be more aggressive in treating your risk factors so that you don’t get dementia and Alzheimer’s.

Dr. Weitz: Yeah. Dr. Houston helped develop a panel, a genetic panel through Vibrant America.

Dr. Orfanos: Cardia, CardiaX, I know. Yes. Yeah, that’s I [00:29:00] like that one too. I’ve done that even on myself. And that can also help direct you if you see if you have more cardiovascular risk genes, there’s one, I have some people with difficult to manage hypertension,

Dr. Weitz: right?

Dr. Orfanos: I have these, this one snip and that responds to an old and an old diuretic called amelioride. It’s been like, it’s 40 years ago, this thing came out.

Dr. Weitz: Oh, really?

Dr. Orfanos: And this just hits this epithelial sodium channel and eliminates the hypertension. People like they’re on four or five drugs.

And you put them on amelioride and slowly peel off everything else and pretty soon that’s all they’re on And that’s on that test, by the way.

Dr. Weitz: Oh, okay.

Dr. Orfanos: That’s cool wow, here’s a drug that’s just made for this condition,

Dr. Weitz: right?

Dr. Orfanos: And I thought that was neat.

Dr. Weitz: So now besides labs What are some of the other testing that you’ll use in your practice to assess?  coronary artery disease and cardiovascular risk [00:30:00]

Dr. Orfanos: Okay I’m limited here. I don’t have anything else. Yeah, but, when I what I learned about was another test called endopat. And that’s a a way to check endothelial function, slap a cuff on your arm and you blow it up till you cut off the blood supply for five minutes.  It sounds hard on you, but it’s not that bad. And then you have these little sensors in your finger, then you see how much you dilate your blood vessels when you release them, release the cuff and the blood, the better that is, the more resilient and healthier arteries are, and you can get judge your treatment by doing that.  Okay. That will be a nice tool to have.

Dr. Weitz: Yeah, I know Mark Houston uses that regulation.

Dr. Orfanos: Yeah, he does. Yeah, he does. Yeah. But again, you have to buy these things and ultimately, if you’re doing all these things, what I’m suggesting to do here with people, their endothelial function got better.  That’s that that, that should happen as part of the right treatment.

Dr. Weitz: As part of the endothelial function, do you [00:31:00] use nitric oxide stimulators?

Dr. Orfanos: I use I use one I used to use, there’s one that has a lot of beet juice, beet root juice in it. That’s a lot of oral stuff. Like the Neo 40.  Correct. Yeah, exactly. And now there’s one that Calroy makes it’s called Vascunox.

Dr. Weitz: Yes.

Dr. Orfanos: Works pretty good. It trip, it triples nitric oxide production. And which persists for 24 hours. So it’ll last the full day. So you just take two capsules once a day and that, that’ll crank up your nitric oxide production.  And if you’re hypertensive, it’ll lower your blood pressure, which is a lot of ways.

Dr. Weitz: I like now what about coronary calcium scans?

Dr. Orfanos: Yeah, I do them. I do them on just about everybody, for 49 bucks, you get a lot of information, meaning do you have calcium or not? That’s the information you get.

But sometimes you pick up aneurysms because they do a CAT scan of the chest, the aorta is [00:32:00] dilated, or you might pick up a nodule outside of the cardiac stuff. Use them routinely. And, if I have a 46 year old guy with coronary calcium, not a lot, but I should just, me. To be aggressive and for coronary calcium, it’s vitamin K two.

Yep. So that can slow coronary calcification and and increased bone mineral density. So it works, puts the calcium where it needs to go. And the aged garlic or IC is the brand, K-Y-O-L-I-C. And that was slow chronic calcification. The H garlic does is good for a lot of vascular things, endothelial function, stuff like that.

Dr. Weitz: And for the K2, are you using the MK4 or the MK7?

Dr. Orfanos: I use the MK7. That’s the one that I’ve been using. I know there’s some controversy over it, but that’s longer, longer lasting. And. I think has more efficacy.

Dr. Weitz: So what do we, since you mentioned those two, let’s say somebody, one of your patients has significant amount of plaque.[00:33:00]

Dr. Orfanos: Yeah.

Dr. Weitz: Do you have a plaque reversal program?

Dr. Orfanos: A K2 aged garlic, omega 3 fatty acids.

Dr. Weitz: How much k2?

Dr. Orfanos: I usually, I use at least 360 micrograms, if not more. 40 to 7 20. I just make sure they got plenty. Okay, box laid all those sites that need to be done like that. I just want to make sure I’m maxing it out.

Dr. Weitz: Some of the patients are nervous about vitamin K because they heard that vitamin K can be related to clotting.

Dr. Orfanos: Not you don’t get excessively coagulable by taking vitamin K, but this is K2. It’s that one that’s for coagulation. Even that, you can take a lot of that. They give people, big shots of it to reverse their coumadin and they don’t like clot up because they do that.

Dr. Weitz: Right.

Dr. Orfanos: So you’re it’s not a risk.

Dr. Weitz: Yeah. Yeah. I totally agree with you. I think the word on vitamin K is if you don’t have enough vitamin K, you won’t be able to clot, but once you have the needed amount, having [00:34:00] more is not going to make you clot more.

Dr. Orfanos: Now, if you’re on Coumadin or Warfarin, they’re called, it’s called a vitamin K antagonist.  That’s how you deplete vitamin K. You shouldn’t be taking vitamin K. Or if you do, you better balance it between the Coumadin dose and the vitamin K. Properly thinned, work it out with your doc.

Speaker: Okay what about a ct angiogram with artificial intelligence to assess soft plaque?

Dr. Orfanos: Yeah, I haven’t, I personally haven’t gotten into that.

It’s called clearly, yes. I think, okay, what would I do if I had somebody I’m just assuming people have some soft plaque. It’s not just all a little bit of calcium that I think they go together. That’s why the calcium was there in the first place because there’s some plaque rupture and which is soft plaque that’s gotten calcified.

So I, I would do what I’m doing. I think the possible plus is if you find somebody with a high grade blockage and doesn’t have any symptoms, [00:35:00] or maybe I’m just going to make an assumption. Then you might catch somebody at a, at the right time to intervene, but right.

Dr. Weitz: You might have somebody with a low coronary calcium scan and they think they’re home free, but if they have soft plaque is even more dangerous than hard plaque.

Dr. Orfanos: Yeah. Yeah. Because it can rupture. I think that’s right. That’s the connection. But if you got but, when you look at the literature, the more calcium in your arteries, the more likely you’re going to have an event, so it’s tied to that 49 really cheap test, and so that’s predictive.  I know it’s sexy to do the whole thing. And I can understand that. And I wouldn’t stop anybody from doing it, but I, but the more calcium you got, the more likely you’ve got coronary occlusion and, I’ll do stress tests on people and do stress echoes or nuclear stress on people with calcium scores.

And, then if it’s negative. Then I know for right now, they don’t [00:36:00] have obstructed seas granted, they can rupture plaque and all that, but if you’re doing all this other stuff you’re changing that risk, you’re moving that risk down. You wouldn’t have, you wouldn’t, let’s say somebody had vulnerable plaque and they were asymptomatic and had a normal nuclear stress.

Those people are low risk to have something happen in spite of worrying about worrying about vulnerable plaque, there’s still low risk. So that’s still, I still being a cardiologist in my mind here, what’s, what are the symptoms? What are my functional tests show?  And then I use the coordinate calcium score just to probably get me to the point where I’m going to do some testing or to inspire the, my patient to change. Hey, you got calcium, you’ve got to do something. Or, in 10 years, you’re going to be in some hot water, so I try to motivate them.

Dr. Weitz: That’s good. So what are some of the other lifestyle factors like exercise that can affect cardiovascular disease risk?

Dr. Orfanos: Sure. If you just, I tell my patients, you don’t have to, you don’t have to get a gym membership and, go to the, we’ll work out six days a week, [00:37:00] if you just get out and walk for 10 minutes, that 10 minute walk.

And that’s in the literature, 10 minute walk will lower your risk. It doesn’t take a lot. And that kind of gets people off the couch, let’s say, and gets them outside. And then, being in nature is actually healing in and of itself. So I get them to do that. I think resistance training, if you want, I think people need to go farther than that.

They need to do more than the 10 minute walk, but still that’ll help, but they need to do resistance training because they got to keep their lean body mass up because muscle is the currency of aging. Thank you. more, the more muscle mass you got, the longer you’re going to live,

you know, just, it’s not just all about falling.

It’s about the metabolic benefits. You’re a muscle, you’re not insulin resistant. You’re insulin sensitive when you got more muscle, but one thing, blood pressure is lower. The other thing is sleep, you’ve got to sleep. Sleep apnea is like overlooked a lot, nobody asks.

And those people with sleep deprivation, their [00:38:00] cortisol levels are high, they’re stressed out, their blood pressure is too high, they’ve got AFib, they’re they’re cognitively impaired. Just look for these things and, people will start to get better and better just by fixing these individual things.

for your attention. And they all work together for the best for the good.

Dr. Weitz: Do you give people a home sleep study?

Dr. Orfanos: I don’t, I, I think in my practice I just, I usually send them to these, one of these sleep center guys and they’ll work them up.  They know how to appropriately get Their tests covered, a lot of times I’ll do it and the insurance company goes you didn’t do the right diagnosis or rights.  So I looked in that way. I let them do it. I want them to get it done and to the sleep doctor to do it.

Dr. Weitz: Yeah, sounds good. So any other topics that we haven’t covered so far that you’d like to tell our listeners about?

Dr. Orfanos: I’ve got this one kind of little passion that I’ve come up with. It’s these it, there, there are these cell membrane [00:39:00] particles that are called plasmologens.

I don’t know if it’s new to me. But the plasmologens are in the cell membranes and they’re, there’s they’re 30 percent of your brain and your heart And they get depleted after you pass about 50. And that alone can lead to cognitive decline and cardiovascular disease and neurodegenerative diseases.

So these can be tested for and you can replace them with a with a supplement basically, by the way, exercise works and muscle building works, but you can take the precursor supplements and build them up. And

Dr. Weitz: What is the test for plasmoligins?

Dr. Orfanos: This one researcher, his name is Goodnow, G O D E N O W, Dan.

He’s a Ph. D. Canadian. He’s come up with a test that, that has, that can measure these and a bunch of other risk factors too. And he’s very scientific about the whole thing, yeah. Struggling to go through all this to learn all that he’s got to say, but the fact that you can, for instance, if your [00:40:00] plasmogens are low, and you’re an E4, an APOE4, and you get them up to like well repleted numbers, you can turn your risk of Alzheimer’s From a, from an APOE 4, which is a 30 percent lifetime risk.

If you got one to just the average risk of if you had three, three, it makes the four risk. You might say

Dr. Weitz: it’s I’m trying to think, I think I’ve heard something about this, is it some sort of a fatty acid type supplement?

Dr. Orfanos: Yeah, it’s a, it’s, there’s a DHA one. which is which is one of them.

And the other one that’s an omega three and the other one’s an omega nine supplement. It’s not olive oil. It’s not fish oil, omega threes are fish oils, omega nines are olive oils, more or less. But you take those precursors, he puts them on the right backbone. So when you eat it, it can get into your system and it gets incorporated into the paroxysomes, which are the little organs in the cells that make these plasmologens.  Ah, it’s.  It’s really cool. That’s all I can say. [00:41:00] I’m really

Dr. Weitz: what’s the company that makes a supplement.

Dr. Orfanos: It’s called Prodrome Sciences.

Dr. Weitz: Okay.

Dr. Orfanos: He named it because he thinks about the program of the disease. Before you get dementia, you’ve got the plasmodium deficiency issue that can be corrected. Huh.

Dr. Weitz: Interesting. Yeah. We’re all concerned about reducing the risk for dementia and keeping your cognitive faculties as sharp as possible as we age.

Dr. Orfanos: Yes, very much

Dr. Weitz: yeah, no, I’ve had Dr. Bredesen on several times. He’s his,

Dr. Orfanos: oh, yes, it’s

Dr. Weitz: brilliant.

Dr. Orfanos: Oh, I love the guy. And I that’s I tell him to read the, read his book, the end of Alzheimer’s program, the people with anything in cognitive decline or whatever, or the risk of it.  And and then I just started telling people, this is all fairly risk, like two months, two months old. This other thing with the plasmologists to read the other to read Dr. Brown. Good now’s book called Breaking Alzheimer’s, which is really pretty technical [00:42:00] reticence, easier easier on the lay persons and the doctor’s mind and the other guy but it’s the stuff’s there, the literature’s there, the studies and all that.

Dr. Weitz: That’s great. And of course, managing stress is super important for cardiovascular health as well.

Dr. Orfanos: Yeah yeah, the more stress you’re under the worse you do. You’re talking about cognition that goes down, cortisol levels go up, blood pressure goes up, blood sugar goes up. Oh there’s other things like a heart math.

You probably know, I don’t know about heart math, where it’s it’s trying to increase your heart rate variability. So we measure on monitors. We didn’t, and it turns out you can, that’s all you can change that by just practicing gratitude, feeling gratitude. So gratitude, appreciation, love, those positive emotions.  up your heart rate variability and guess what? Your blood pressure comes down your heart rate comes down you’re smarter, you do better on tests, your cholesterol [00:43:00] drops, your cortisol level it’s wow, one thing like that can do.

Dr. Weitz: So do you use heart math in your practice?

Dr. Orfanos: I do, this is more peripherally, I tell people about it more than I, I used to have these little devices and I have one at home where you you plug it into your iPhone, it’s a program and you click it on your ear and then you can measure your heart rate very, you can watch it go from red to green, red is like K, green is coherence,

Dr. Weitz: yeah, I measure it with the aurora ring.

Dr. Orfanos: The Oura ring does it? Okay. Okay. So yeah, it’s gives you an idea of where you’re at emotionally, psychologically.

Dr. Weitz: Absolutely. Yeah. It’s some cool wearable devices and they’re getting better and better. Yeah. All right. Great. Any final thoughts for our listeners and viewers?

Dr. Orfanos: You’re never too old to get better. So don’t let the years get in the way of you’re improving your overall health and. And [00:44:00] health span and probably lifespan.

Dr. Weitz: Absolutely. Dr. Ofanos, how can listeners get a hold of you?

Dr. Orfanos: You can contact us at Case Integrative Health, CASE, Integrative Health in Chicago.  And and through that website, you can get a hold of me and if you’d like to see me, I’d be glad to see you. So

Dr. Weitz: what’s the exact website?

Dr. Orfanos: It’s called, if you just Google case integrative health, it should pop up.

Dr. Weitz: Okay, great. And, and do you do remote consults as well?

Dr. Orfanos: Yes we do, but we, we see people in person for at least the first visit and once a year.

Dr. Weitz: Okay, great. Thank you.

Dr. Orfanos: You’re very welcome.

 


 

Dr. Weitz: Thank you for making it all the way through this episode of the rational wellness podcast For those of you who enjoy Listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review.  If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. Some of the areas I specialize in include helping patients with specific health issues like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111. And we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

Dr. Howard Elkin and Dr. Ben Weitz defend the Therapeutic Use of Niacin.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.]

 

Podcast Highlights

0:39  Niacin.  Niacin is vitamin B3 and it is found in many foods and most multivitamins and we know that not having enough niacin can lead to a life-threatening condition–Pellagra. Today we want to comment about a new study in Nature by Dr. Stanley Hazen and colleagues that questions whether the therapeutic use of niacin is safe or effective because a downstream metabolite of niacin–4PY–promotes vascular inflammation and contributes to cardiovascular disease risk.  The paper, which was published in February 19, 2024 is called A Terminal Metabolite of Niacin Promotes Vascular Inflammation and Contributes of Cardiovascular Disease Risk.

2:12  Niacin has been a very effective therapeutic tool to reduce cardiovascular disease risk and it has many unique properties, including that it reduces small, dense LDL, increases LDL particle size, reduces triglycerides, increases HDL, improves HDL functionality, and is pretty much the only effective therapy to reduce Lp(a).

4:14  Statins. Niacin was a very popular treatment for high cholesterol until statins came out and then everything changed and statins became the go to drugs for reducing cholesterol.  Statins do a good job of lowering LDL but they don’t increase the size of the LDL particles and particle size is more important than LDL, which is why you should do advanced lipid testing. Small, dense LDL is more dangerous than large buoyant LDL.  In fact, LDL is less of a culprit than oxidized LDL and small, dense LDL particles are more likely to be oxidized. Lp(a) is a fragment of LDL that sticky and inflammatory. Niacin can help in both of these situations where statins do not.

7:23  A large number of studies over the years that have shown significant benefit with using niacin.  Dr. Hazen points out in this paper that because patients who are taking very strong medications like PSK9 inhibitors to reduce cardiovascular risk still have have heart attacks, so there must be some additional markers to screen for this risk.  This is why he searched for new biomarkers and found this downstream metabolite of niacin–4PY that appears to be associated with inflammation. He points out that 4PY is associated with vascular adhesion molecule one, VCAM1.  This is quite ironic, since a study in 2010 found that niacin reduces VCAM1 (Wu BJ, Yan L, Charlton F, et al. Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010;30:968-975.).  But if Dr. Hazen wanted additional biomarkers outside of a basic lipid profile, he does not need to look any further than the markers in an advanced lipid profile, such as the one developed by Cleveland Clinic, where Dr. Hazen works.

10:48  If Dr. Hazen is saying that niacin is unsafe because it leads to 4PY, since none of these patients were taking therapeutic niacin, then we should all stop eating salmon, sardines, nuts, and avocados, and a bunch of other healthy foods that naturally contain niacin. 

 



Dr. Howard Elkin is an Integrative Cardiologist with offices in Whittier and in Santa Monica, California and he has been in practice since 1986.  While Dr. Elkin does utilize medications and he performs angioplasty and stent placement and other surgical procedures, his focus in his practice is employing natural strategies for helping patients, including recommendations for diet, lifestyle changes, and targeted nutritional supplements to improve their condition.  Dr. Elkin has written an excellent new book, From Both Sides of the Table: When Doctor Becomes Patient.  His website is Heartwise.com and his office number is 562-945-3753.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz:  Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, drweitz.com.  Thanks for joining me and let’s jump into the podcast. Hello, Rational Wellness Podcasters.

I’m very excited to be speaking with one of my favorite guests, Integrative Cardiologist, Dr. Howard Elkin again. And today the topic is niacin. Niacin is vitamin B3. It is found in many foods.  It’s found in most multivitamins.  We know that not having significant amounts of niacin in the diet leads to pellagra, which is a life threatening disease.  And so we have known about the benefits of niacin, but today we really want to talk about the Therapeutic use of niacin in higher dosages, which has been used by cardiologists and now very commonly by integrative and functional cardiologists to decrease cardiovascular risk.  And it has been used safely, has a lot of unique properties and benefits, and It seems to be periodically under attack and now it seems to be under attack again. And the Dr. Elkin and I thought it was important to comment about a new study which was published in Nature by Dr. Stanley Hazen of Cleveland Clinic and colleagues.  The name of the paper is A Terminal Metabolite of Niacin Promotes Vascular Inflammation and Contributes to Cardiovascular Disease risk.  Dr. Hazen argues that a metabolite of niacin, or PY, is associated with increased risk of major cardiovascular events.

But we also know that niacin has proven to be a very effective tool for decades in reducing cardiovascular disease risk.  And it’s unique in many of its properties, and I’m just going to mention a couple, and Dr. Elkin and, and I will go into more details, but it’s pretty much the only substance we know that can reduce small dense LDL and increase LDL particle size. It reduces triglycerides. It’s, it’s pretty much the only effective tool for increasing HDL and improving HDL functionality.  And it’s really, at this time, the only effective therapy for reducing LP little a.

Dr. Howard Elkin is an integrative cardiologist with offices in Whittier and in Santa Monica, and he’s been in practice since 1986. While Dr. Elkin does utilize medications and performs angioplasty and stent placement and other surgical procedures, his focus is really On employing natural strategies for helping patients, including recommendations for diet lifestyle and targeted nutritional supplements like niacin to improve their condition.  Dr. Elkin has also written an excellent book From Both Sides of the Table: When doctor becomes patient that’s available on Amazon, Dr. Elkin, Thanks for joining me again.

Dr. Elkin: Thank you, thank you Ben so much, and I appreciate being here. This is a topic that’s very dear to my heart because, pun intended, because it’s like every so often, like every few years, they come up with another say that disses or throws niacin under the bus and my [00:04:00] niacin, if you look historically, has been around, first of all, it doesn’t bite, like you say, it’s vitamin B3, it’s been around forever.  I mean, in the 60s and 70s, that was one of the few things we had to even lower cholesterol. And it did it pretty, you know, pretty okay, did a good job of it. And then everything kind of changed when statins came about, and I was actually a fellow at Northwestern when the first one, Mevacor, came out. I remember that Time magazine with the, with the cover was like, you know, fried egg with, I think it was bacon for eyes or a mouth or something.  And really, statins became very popular because they do something very well. They lower LDL, and they lower it quite nicely, and more potently than niacin. Well, but you’ve already mentioned what niacin does, but that, I mean, I could give someone 80 milligrams of Lipitor and it’s not going to increase the size of the LDL particle.  So, why do I care about that?  Because particle size is really more important than the LDL by itself, and you have to do really advanced lipid testing to test for that. So, small dense is less preferred than large fluffy or large buoyant, and because of the fact that small dense is like, you know, almost 30 percent more likely to get oxidized.  So LDL isn’t so much the culprit, it’s oxidized LDL. And we know that small dense particles have a predilection for that. Same thing with LP little A. LP little A is a fragment of LDL. It’s sticky. It’s inflammatory. We don’t like it. And so it’s, and it promotes inflammation. It does oxidation of LDL, so those, those are two components right there where niacin comes in in handy.

It will decrease triglycerides, it can increase HDL, it can increase HDL functionality, which is important because you can have a high HDL number yet it’s dysfunctional, and you don’t know that unless you test for it, and Cleveland Heart Lab does that. Um, so, I mean, definitely in accordance with you, this article did not talk about any benefits of niacin.  It just said, well, if you happen to have one of these horrible toxic metabolites, you know, you’re more likely to have toxic effects in a way called MACE, which is, you know, major Adverse cardiovascular events, that’s the term we use, and they looked at mace over three years. But there’s a lot of, you know, fallacies of the study.

First of all, you have to have a certain polymorphism or single nuclear polymorphism to even have the, this, this, these, to break down to these toxic metabolites. So probably at the most, one out of four, I mean, we don’t even know the number of people that are affected by this, but I can promise you in 37, almost 38 years of practice, I’ve never had a problem with niacin such as this–someone developing a heart attack or stroke. So I think it’s been taken way out of context.  I’m not saying there’s no validity in toxic metabolites. I mean, every drug, or every substance will break down. It’s how it breaks down.  And so we found these, the 2PY and 4PY, but you have to have the SNP in order to break it down. So it’s, it’s really taken out of context because I think most people really are not affected by this. And therefore the study is really not nearly, it’s important. It’s, I mean, they call it the Niacin paradox.  It’s supposed to help, but it doesn’t. Why? I beg to differ with that.

Dr. Weitz:  Right.  And there’s been a large number of studies over the years that have shown significant benefit with using niacin, including reducing blockages in the arteries, including reducing cardiovascular risk. And one of the things that Dr. Hazen points out in this article at the beginning is that patients who were taking these PSK9 inhibitors, which are the most potent drugs we have to reduce LDL, that some of the patients still have heart attacks. So his conclusion is if LDL is not enough to understand why people are having heart attacks, let’s see what else we can find.  And so he’s searching through the blood of patients who have cardiovascular disease, none of whom, by the way, were being prescribed niacin. So none of the patients in this study were prescribed therapeutic niacin. So there’s nothing that can be said on the basis of this study that applies to the therapeutic use of niacin.  And he found that a certain percentage of patients had these Toxic metabolites.  And the one that was the most significant is the 4PY. And he also found that that 4PY was associated with with inflammation.  And he correlated in some in-vivo studies that it’s associated with vascular adhesion molecule one, VCAM1.

First of all, I want to point out that I think the main message I would like everybody to get from this discussion is that if Dr. Hazen realized that patients who were taking effective lipid lowering drugs were still having heart attacks. Instead of searching for some obscure downstream metabolite that only occurs in a percentage of patients with a certain genetic SNP, all he needed to do was look at an advanced lipid profile to get information about what other factors are important in lowering cardiovascular risk. And unfortunately, statins and PSK9 inhibitors, don’t do anything about addressing LDL particle size. They don’t increase particle size. They don’t increase HDL functionality.  They don’t significantly lower Lp(a).  PSK9 inhibitors do a little bit, but actually not as effectively as niacin does.  And so I think the answer is look at an advanced lipid profile. Look at homocysteine, look at metabolic factors. When you put that whole picture together, I think we do have a much better assessment of understanding cardiovascular risk because LDL C alone is not enough.  And I think he’s absolutely right about that. He, we just don’t need to look for this obscure, downstream metabolite of niacin. And so if what Dr. Hazen is saying that niacin is unsafe because it leads to 4PY and none of these patients were taking therapeutic niacin. Then what he’s saying is, is that we should all stop eating salmon, sardines, nuts, and avocados, and a bunch of other healthy foods that naturally contain niacin.  As well as avoiding niacin supplements and taking multivitamins. And I think that goes against everything we know about nutrition and… 

Dr. Elkin:   Interesting. I think the real paradox, the niacin paradox, the real paradox is that this guy is from the Cleveland Clinic. Cleveland Clinic has premier, I mean, Boston and Cleveland Clinic have the best advanced lipid testing out there. 

Dr. Weitz:  Exactly.

Dr. Elkin:   It’s right available at their fingertips.

Dr. Weitz:  Look at your own testing, dude!

Dr. Elkin:   Look at your own testing, because you’re going to find answers there. And potentially all my patients that have elevated cholesterol, which is, as you can imagine, a hell of a lot, I always do advance the testing. If the baseline is abnormal, I’m going to go test it.  To, [00:12:00] and most, in many cases, I go straight to advanced testing, but that’s where I’m going to get answers. That’s where I’m going to find out about risk factors and inflammation and metabolic aberrations, not by l, not by this study. It doesn’t help me at all.

Dr. Weitz:  By the way, interestingly, I looked into some of the literature and this association, the reason why I mentioned this technical name, vascular adhesion molecule one, VCAM one is because there’s a study in 2010, (Wu BJ, Yan L, Charlton F, et al. Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010;30:968-975.), that shows that one of the benefits of niacin is that it reduces inflammation by reducing VCAM one. So interestingly, therapeutic higher dosages of niacin reduced VCAM1.  However, patients who are found to have 4PY were patients who, as far as we know, had probably relatively lower levels of niacin because none of them were taking niacin. So we don’t know this, but maybe, maybe there is a J shaped curve and he’s measuring people with low levels of niacin, and maybe people who had higher levels actually have lower level of vascular adhesion molecule and lower levels of inflammation and atherogenesis.

Dr. Elkin: And I think one of the reasons why we’re doing this is that the day after the study came out, I kid you not, I got four phone calls from my patients. Should I be should I be taking the shot to stop my niacin?  I’m, really worried about this study. It went viral in a matter of hours, of course

Dr. Weitz:  And that’s what happens with the press, unfortunately so now um this paper in order to bolster their findings also Mention two previous other trials That have been used.  In fact, 10 years ago they were used and it was all over the news. Um, that niacin’s not good to take. And these were the HPS Two Thrive study and the AIM High trial. [00:14:00] So why don’t we take a quick look at these two trials and why don’t we start with the HPS two Thrive trial that gave patients who had a history of heart disease 40 milligrams of simvastatin, along with high dose extended release niacin, along with an investigational drug from Merck called lariparipant, which decreased the flushing effect of niacin.  And this study did not show a reduction in cardiovascular benefits after approximately four years.

Dr. Elkin:  You know, first of all, it was a non flushed, right? That was the compound they used.

Dr. Weitz:  Well, they used this additional drug to reduce the flushing. So they used extended release niacin, which does flush, along with this other investigational drug.

Dr. Elkin: First of all, my problem with that is that you’re not talking apples and apples anymore. You’re not just talking about niacin. Pure niacin, which is the only thing that I recommend. I use supplemental form. I don’t use the pharmaceutical brand because you take it once at night with your evening meal and then you wake up at 2 am with flushing.  The flushing is extended and it also has liver abnormalities. I use regular supplemental niacin. There’s several good companies out there that make it. But it’s the non flushed, first of all, It, it doesn’t, it’s not the same thing and it doesn’t work. It simply doesn’t work.

Dr. Weitz: So the reality is this additional drug, lariparipirant, which is not on the market, is associated with a lot of the side effects that they attributed to niacin.

Dr. Elkin: Exactly, exactly. So, again, this is another example. You know, this study was, that’s 2014, if I’m not correct. Correct, right? 2014, 10 years ago. And, by that time, statins had their main, I mean, statins were, it was right before PSK9 inhibitors came out. PSK, PSK9 inhibitors came out, I believe, about 8 years ago.  And that changed things a bit, but and there’s another argument they had about niacin, if I’m not mistaken, right? 

Dr. Weitz: Yeah. So there was, there was there was also the aim high trial and this used a time release niacin added to statin therapy. And, you know, another problem with both of these studies is.  Niacin, a lot of its benefits will be most profound with patients, um, who have higher levels of, of cholesterol and triglycerides, et cetera. So when you already start out by pre treating the patient for a while, um, with, um, statins, you’re going to [00:17:00] decrease some of the benefits. Even this aim high trial, which found that there was no additional reduction in heart attacks.  Um, uh, it, it, it actually did show significant improvements in several cardiovascular disease risk factors, including increased HDL from 35 to 42. Lowering of triglycerides from 1 64 to 1 22.  Further lowering LDL cholesterol and lowering LP little a.  And so I, I think both of these trials are  flawed and really don’t refute the benefits of niacin.

Dr. Elkin: I think one benefit, you already mentioned it, when you increase HDL and decrease triglycerides, you are affecting the metabolic milieu, because almost 95 percent of the population in this country is metabolically unhealthy, and that’s a major culprit in coronary disease and heart disease in general.  And these parameters are not affected by statins or even PCS can inhibitors to a certain extent. So there is benefit to niacin, which was never mentioned in these studies. Um, yeah, it’s like, it’s easy to do something. And, and, but I certainly, I was a physician treating lots of patients with lipid disorders for over, really, I worked with Robert Sperko in Berkeley Heart Lab 25 years ago.  That’s when I learned about particle size. No one was even talking about that back then, and that’s when I started using, but niacin, it’s, you know, and I still use it and I have not stopped it in any of my patients, despite all the phone calls I got. And so I just think it, this study was just really.  It was taken out of context, and [00:19:00] our job is to teach the public that, you know, you have to know both sides of the story.

Dr. Weitz: Yeah, it was a basic science study. It was not a study that tested therapeutic use of niacin. And then, further, part of a message from doctors like you and myself who practice integrative functional approaches are that when you treat the whole patient and you address their diet, their exercise, their stress component, and then you layer in some of these additional therapies like niacin and possibly statins or other medications.  The overall therapeutic benefit you’re going to get from these patients improving their metabolic profile, reducing overall levels of inflammation is going to be far superior than just taking people following the standard American diet, leading a sedentary lifestyle, and just throwing in some pharmaceuticals.

Dr. Elkin: Exactly, exactly. So as Ross said, so I mean this is a great, there’s a lot of other studies that we can talk about, but I think the niacin issue is a big one and I think not stopping a niacin just because of this one study is uncalled for.

Dr. Weitz: And niacin has these unique benefits that we’ve mentioned, like, for example, improving HDL functionality.  Interestingly HDL has sort of been the forgotten cardiovascular risk marker. And, and, and unfortunately, a lot of the data around some, some medicine has to do with whether or not we have a pharmaceutical to treat it. So most doctors are, they, they’re waiting, conventional medical doctors, primary care doctors, cardiologists, They don’t measure these other things.  They don’t measure HDL functionality. They don’t measure LpA. Why? There’s no drug to treat it. In a couple of years, there’s going to be one or several drugs that are on the market that effectively lower HP, LpA, and you’re going to see everybody testing LpA. But right now, they don’t care because They don’t have any means to reduce it, but we know that niacin can produce, uh, a 30 to 70 percent reduction in Lp(a).

Dr. Elkin: exactly.  I think, yeah, once the medic, the pharmaceuticals come out, it’ll be, it’ll go viral, you know, they may be treating it.

Dr. Weitz: Right. And the same thing about HDL is they’ve tried to come out with several drugs to raise HDL and they haven’t been effective in reducing risk. Right. And so, you know, one of the [00:22:00] morals of the story is there is different ways to accomplish the same thing.  And we see this also with trying to control metabolic syndrome and controlling blood sugar and insulin. And if you do it with very aggressive drug therapy And and you just keep increasing the medications to lower Hemoglobin A1C.  We actually have negative effects on people’s health and and and some Some doctors have concluded, well, you shouldn’t try to reduce your blood sugar and your hemoglobin A1c too aggressively.  Well, no, that’s not the answer. The answer is if you do it naturally, if you get people to change your diet, stop eating ultra processed foods, start eating a lower glycemic diet, start exercising appropriately, manage your stress, get proper sleep. [00:23:00] You’re going to find that. They’re going to significantly lower their risk of death and, and all cause mortality and everything else.  But if you just do it with drugs, that’s not the answer.

Dr. Elkin: I concur a hundred percent. And that’s it.

Dr. Weitz: That’s it. So I there’s another study that just came out, but I know we’re short on time. So you and I are going to get together in a few weeks and discuss this other trial that seemed to show that LDL is completely irrelevant.  Right. Exactly. Okay. So, so Howard, how can our listeners, get ahold of you and contact you if they want you to help them?

Dr. Elkin: Okay. Very good. So my website is Heartwise.com. That’s one word Heartwise. And I also, my book is Be Your Own Medical Advocate. com, but you can see me on Instagram under DocHElkin. or Facebook, uh, Heart Wise Fitness and Longevity Center.  But I’m pretty connected to social media, so I’m glad you had to answer your questions and so forth. But, uh, you know, I love doing this, not that I’m into much dissecting studies, but doctors, so they just look at a study at face value and then the pharmaceutical reps come in there and push meds. And, you know, and I understand because we’re really limited in time, but there’s no substitute for interpreting a study and diving into it like we just did.

Dr. Weitz: I just want to point out again that we’re not trying to bash medications. Medications can be very beneficial, but if they’re integrated into a full care program where you’re helping patients to improve their diet, improve their lifestyle, exercise regularly, get proper sleep, manage their stress, and then you add in the proper nutritional supplements to meet all their nutritional needs and then add in the proper medications to top it off.  That’s a completely different picture than taking a metabolically unhealthy a sedentary American eating the standard American diet, eating ultra processed foods and try to lower their risk just with medications.

Dr. Elkin: 100 percent agreed. You know, that’s why in integrative medicine, we integrate lifestyle.  Lifestyle was always number one in my book. Yeah, I use a lot of medicines. I have sick cardiac patients, but I always vouch for that. I did a YouTube live on hypertension and may it’s also blood pressure awareness month. And you know, with With weight loss and exercise in that order, we could probably wipe out stage one, you know, mild hypertension.  But by the time people are diagnosed, they’re stage two already. They’re, you know, they have advanced disease because no one’s talked about lifestyle.

Dr. Weitz:  Diet and exercise for weight loss?  I thought weight gain was caused by a deficiency of Ozembic.  Thank you, Howard.

 


 

Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast. I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues like gut problems. neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen. And to help you promote longevity. And take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111. And we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

Dr. Maggie Ney discusses Bioidentical Hormone Therapy at the Functional Medicine Discussion Group meeting on April 25, 2024 with moderator Dr. Ben Weitz.  

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

5:49  Women go through four basic hormonal stages: 1. Premenopause, 2. Perimenopause, 3. Menopause, and 4. Post-menopause.  Premenopause is from when you get your first period until you start perimenopause.  Perimenopause is the time when our higher quality eggs start to decline and we begin to experience fluctuating hormonal levels. Women can have a regular period, but the regular rhythmic flow that women are used to experiencing with the regular upping of estrogen and decline and the production of progesterone that occurs during the second half of the cycle, doesn’t happen as predictably.  Menopause, technically is one day, the one day anniversary since your last menstrual period.  Everything after menopause is Post-menopause and you will have low hormones till the day you die, though symptoms can change over time.

7:08  Perimenopause.  Perimenopause is not a constant, symptomatic phase.  Symptoms can flare, usually with various stressors, such as lack of sleep, poor diet, and if our body is under stress, so how you treat your body during this period matters more for how you will feel.  This phase can last from four to ten years.  This talk focuses on hormones, but the lifestyle piece that includes diet, sleep, and vitamins, minerals, herbs, and homeopathy is also very important.  A lot of women can benefit from extra hormone support during perimenopause.  Today only 4-5% of women are on hormone therapy but 80-90% would be excellent candidates. Women are experiencing hormonal fluctuations that are affecting their mood, brain health, energy, and their ability to manage stressors.  And this is a time when many women are at the peak of their careers, while also taking care of their children and their aging parents.  Women at this point in their lives need to focus on lifting weights to build muscle and promote better bone density, as well as balance and stretching. For nutrition, women need to focus on keeping a stable blood sugar, optimizing protein intake, and metabolic flexibility.  They also need to get morning sunlight, have quality relationships, joy, stress management, address gut health, support detox pathways, take targeted supplements, and hormone therapy.

 

 



Dr. Maggie Ney is a licensed naturopathic doctor and a Menopause Society certified practitioner. She’s the director of the Women’s Clinic at the Akasha Center for Integrative Medicine in Santa Monica, California, where she has been supporting women through perimenopause and menopause since 2006. Dr. Ney is co-founder of HelloPeri, (TheHelloPeri.com) an online resource for women going through perimenopause, and she’s been featured on The Doctors show and Goop for expertise on women’s health and hormones.  Her website is DrMaggieNey.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz: Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates and to learn more, check out my website, drweitz.com thanks for joining me and let’s jump into the podcast.


Our two sponsors are Integrative Therapeutics and DUTCH Testing. And if you’re not aware, Integrative Therapeutics is one of the premier,, professional brands of supplements available.  we use a lot of their products in our office. One of their,  most exciting products is their specialized form of curcumin called Theracumin, Theracurmin.  And now they have an even more specialized, more highly absorbable form called Curalieve. They have many other products that can be helpful for hormonal balance as well.

 


And now we have our other sponsor for this evening is, Dutch Testing, Precision Analytical Labs. And so we have Noah Reed here to tell us a little bit about Dried Urine Testing:

Noah Reed: Yeah, thanks for having me.  I came down from Oregon, so glad to be here with you today.  DUTCH stands for Dried Urine Testing for Comprehensive Hormones, so that’s what the acronym DUTCH stands for.  It’s a four spot dry urine test, so waking two hours later, dinner, and bedtime.  It gives you the average of the sex hormones throughout the day, so it can mirror 24 hour urine, but it’s a little bit easier to collect, because it’s just on a little filter paper. that the patient takes at home, gives you the metabolites, so how the body is detoxing the hormones. You also get adrenal health with that, so you can be able to see the four points of the cortisol curve throughout the day land you see the metabolites of cortisol, how much cortisol is being made and how the body is processing it.  It gives you a little bit of an interesting view there, and then a very small organic acid panel, , gives you melatonin production through the night and 8 hydroxy 2 deoxyguanosine, or 8 OHTG, which is the oxidative stress marker, all in one, easy to use, test that the patient does at home.  We do have doctors on staff, 12 doctors that can walk you through the interpretation as well, so that you can become the hormone expert for your patients.  So that’s a little bit about the DUTCH test. If you have any questions, I’ll be here.  I’d love to answer any more questions for you.  We do kind of pride ourselves on the three things that make us unique.  Our comprehensive, a comprehensive report that’s visually appealing for you to be able to understand your patient’s story. , the support from our clinical clinicians on staff. , and then everything that we do is backed in peer reviewed journals. , so every analyte that we have on our test is actually put in a peer reviewed journal.  Our most recent one that we’re proud of is we were published in the journal Menopause, so we were the first functional test, , to actually be published in the journal Menopause, , showing the efficacy of testing and monitoring, , hormone replacement therapy, , as a part of your patient, , experience.  So, that was a big feather in our cap to be a part of that, and we’d love to talk more about it if you have any questions. 


Dr. Weitz: Thank you so much, Noah. Our speaker for this evening is Dr. Maggie Nay. She’s a licensed Naturopathic doctor… Unless you want to introduce yourself?  That’s fine. Yeah. Okay. Okay.

Dr. Maggie Ney:  Hi, everybody.  Hi. I’m so excited to be here.  I’m really passionate about women’s health and perimenopause in particular. I find it a very underserved area in the market. So I love to educate women and practitioners, and would love for this to be interactive if you guys have questions, but, I’ll start a little bit about introducing myself.  I’m a naturopathic doctor. I graduated from Bastyr University in Seattle in 2006. I currently co direct the women’s clinic at the Akasha Center for Integrative Medicine, which is like a few blocks away. Thanks I recently co-founded Hello Peri, which is an online resource really devoted to educating women about perimenopause.  I’m a certified practitioner by the Menopause Society. And again, I just really like to help women thrive through the perimenopausal period with a sense of empowerment. I’d like to provide the resources, tools, strategies needed to support hormones and for women to truly feel incredible because I do think this is the time when women can absolutely get after all their dreams, right?  This is the week in Chinese medicine, right? The second coming. You can choose your own path, write your own script, but gosh, it helps to feel really good to be able to do that.

Speaker: Yeah, I don’t think so. You know what? I’ll, I’ll, and she’s like, well,

Dr. Weitz: I can do it. I’ll, I’ll do it. I got it. I got it. I’ll do it. I’ll do it for you.

Dr. Maggie Ney:  Thank you.  I use so many pronouns, so I do just want to just really quickly say however you identify your patient. I do, I do use she/her to identify women, but I know that, you know, everyone identifies a little differently.  But just for the sake of being clear and not too wordy, as you can know, I chat a lot. So. We’re going to, everyone is included. However you or your patients identify yourself. Just want to put that out there. Alright, we can move on. Okay.

So really briefly, let’s just review the four basic hormonal stages that women go through.  So first we have the pre menopause time, which is basically from when you get your first period up until when you start perimenopause. Perimenopause is this time when our higher quality eggs start to decline, and we begin to experience more fluctuating hormonal levels. So women can start to have, , women can have the regular period, but start to have these symptoms, which we’ll get into, and you can still get pregnant.

But the regular rhythmic flow that women used to experience with the regular upping of the estrogen, the decline, progesterone being produced during the second half of the cycle, doesn’t happen as predictably. Menopause, technically, it’s one day, it’s the one year anniversary since your last menstrual period.  And then everything after is the post is post-menopause. I prefer to use post-menopausal years because we get a little hung up on, I’m after menopause, it’s done, it’s over, I’m through it.  But really, once you’re in post-menopause, the hormones are low and you’re going to have low hormones till the day you die.  So it’s not like you’re through with it, you’re in it, really. Symptoms can absolutely change, though, throughout that time.

Okay, so let’s talk a little bit about the unique needs of perimenopausal women. So, again, this is the period of time leading up to menopause. Hormones can start to fluctuate and symptoms can occur in your 30s. For some, sometimes late 40s, and perimenopause is not always a con Do you guys hear me okay?

Perimenopause is not always a constant symptomatic phase. Symptoms can flare with times of higher stress, and this is a hallmark, is that during this perimenopausal time, hormones become even more sensitive to stressors. Right? So if you’re Whatever could be situational, lack of sleep, poor diet, if our body’s at all under stress, our hormones are more easily affected.  Symptoms can last really on average between four and ten years. And I just want to just highlight that. If you’re feeling like crap, I mean that’s a very long time. And once a woman has gone a full year without a period, they’re in menopause. And again, it’s the one year anniversary without a period and patients that are post menopause.

And lifestyle changes become more important than ever during this time, right? Sleeping, hydration, nutrition, movement, dress management, quality relationships, can dramatically affect how a woman experiences perimenopause, right? I always say to my patients, Yeah, in college you can stay up all late, you can drink beer, eat pizza at midnight, wake up and like, go to classes and feel like, happy on your A game, but that just doesn’t happen.

How are you? It’s not like, I would say again, like, you can continue to age with the same level of energy and vitality, even more so than when you were younger, but how we treat our body matters, and it matters more now.  Okay, so I didn’t really say this, but I am going to focus here mostly on hormone therapy, because this is an area that is really not understood most of the time.  Practitioners and women don’t feel like this is an option during the perimenopausal period, so I like to educate on this. But again, if you have questions about some of the other treatments, please ask me.  okay, so, yeah, so, again, we focus on the lifestyle piece. There are vitamins, there’s minerals, there’s herbs, there’s homeopathy.  I know you guys are well trained in this area. That can be helpful. But a lot of women do need that extra hormone support during this time to really feel their best. And most important, all women need to have a conversation. Right, I, this is what fuels me, is that women are denied the option. Women aren’t given the full amount of choices that they can use during this time.

So the benefits of HRT really is greater than the risk for most [00:10:00] symptomatic women. Currently, I think the most recent numbers is like 4-5 percent of women are on hormone therapy, when really upwards to 80 90 percent would be excellent candidates. Doctors and other healthcare practitioners are not getting good training in their schooling to be able to recognize and how to use hormone therapy safely and comfortably. I talk to a lot of doctor colleagues, they just don’t, they know it’s okay, but they don’t feel comfortable.  Okay, so, again, just again to speak about the unique needs of a perimenopausal woman, I’d just like everyone just to be aware of, perimenopausal women are usually in the sandwich generation, right?  They’re at a time in their life where they’re experiencing these hormonal fluctuations that can affect all aspects of our body, mood, brain health, energy, and the ability to manage stressors. At the same time that our lives are often more demanding and stressful. Many women are at the key of their career while also taking care of their own children and aging parents.

And this is a time for patients really to focus on lifestyle more than ever and prioritize personal health and hormone education so they can really show up As their best version of themselves. And for many women, it’s simply a perfect storm. That the hormones and life stressors are happening at this exact time that hormones are shifting.  So, a comprehensive approach to perimenopause. We’re looking at, well, we definitely want to get a very good past medical history. A thorough understanding of their current symptoms, family history, lifestyle. So important to know our patient’s health goals. Because that can help individualize our treatment plan.  And focusing on things like nutrition, hydration, movement. And for the perimenopausal women, it’s really about getting good cardio resistance, right? Lifting weights is more important to build that muscle because we lose more bone mineral density as we go through the perimenopausal journey, so we need to focus on building muscle because it’s good for muscle, it’s good for bones.  Women need to focus on balance and stretching. For nutrition, keeping blood sugar stable, metabolic flexibility, optimizing protein intake, but again, all the other things, morning sunlight, quality relationship, joy, stress management, addressing gut health, supporting detoxification pathways, targeted supplements, and hormone therapy, and if you can include all this in your plan, you’re doing comprehensive, perimenopausal care.

So, I, a few points I want to make that come up to me as a naturopathic doctor. Gosh, I, I’m a natural, I like to call it naturally, they do things naturally. I want to support the natural process of my body and I’m supposed to go through menopause. Why don’t I just honor that and accept it? It makes sense, but we all need to question what is natural these days.

Like, are we supposed to live to 80 and 90? Are we supposed to be? You know, super physical and active mentally and physically. I mean, I know I want to be. I want to be super active and having fun and hiking up until the day I die and, and we’re living longer than ever. We used to die just past menopause and now we’re living, you know, up to half of our life after menopause and to have an expectation that we can do that with the same level of energy and vitality As we did when we were younger, it’s not realistic for most people if they’re not using phones.

For some, yes, again, it’s individualized, but we just need to be aware of this. And there are risks, I’m not quite done, there are risks to not addressing our patient’s health as well. Hot flashes and night sweats aren’t just annoying. They’re not just something you need to embrace and move through. There are consequences to it.  We know that it obviously can disrupt sleep, which can affect every aspect of our life. But there’s also more vascular inflammation when women experience hot flashes and night sweats, which does put them at higher risk of heart disease and dementia.  also for women, Depression and suicide rates are skyrocketing for mid life women.

It is true that [00:14:00] suicide rates for mid life women is, it peaks then. And if a woman is presenting for the first time during this time period with new onset depression or reoccurrence, then it really truly needs to be taken very seriously and we need to recognize and, and discuss the hormonal component as well.

So what’s happening hormonally specifically during perimenopause? So, basically, our estrogen starts to behave a little bit more erratically. So, during the pre menopause years, our estrogen in the follicular phase basically starts off low and basically steadily increases. It gets to a certain point where it signals to the brain to release luteinizing hormone, which triggers the egg to be released, so we ovulate, there’s a little dip in estrogen, and then it boosts back up again, and then it drops.  And then,  during perimenopause, that estrogen just doesn’t really have rhyme or reason. I mean, some months it can [00:15:00] go regularly just like that, and other months the estrogen is just up and down and up and down and up and down throughout the cycle. And women feel it because our brains like stable hormones.

They just do. We do better. That’s why women, have a little mood issue. Sometimes we’re out of population and obviously during the premenstrual time when we’re PMSing, it’s because of these drops in hormones that trigger changes in our neurotransmitters that can affect our mood. So, again, these estrogen fluctuations can lead to more unpredictable mood changes.

70 percent of women in period menopause have mood changes. Anxiety, depression, irritability, moodiness, less able to manage day to day life and depression. And stressors feeling less resilient. So, the stressors that we used to be able to handle with ease can just feel too much. Estrogen fluctuations can also be a trigger for headaches, more aches and pains, and night sweats and hot flashes.

And then, as [00:16:00] progesterone starts to decline, so often during early period menopause, it’s progesterone, which is the first hormone to drop. That will show up in our clients and our patients as difficulty sleeping, difficulty turning our brains off at night, feeling more anxiety on edge, and then having shorter cycles.

So, if you were a 28 day girl, maybe you’re more 27, 26. Which is why it’s really helpful for our patients to track their cycles so we can begin to recognize those subtle shifts.  heavier cycles and more spotting between periods. So these are separating a hormone and getting an idea of what symptoms can be related to what hormones.

And because perimenopause can really be a decade, I do think of it as early versus late perimenopause. Where the earliest symptoms really are the symptoms of that lower progesterone, which we just spoke about, where periods can start to come a little early, sometimes you’ll have two periods in one month, you have heavier periods, [00:17:00] clottier, heavier flow, lower libido, ruminating thoughts, anxiety, depression, less resilient, sleep issues.

And then the later period menopause, you were really starting to see women skip their cycles. You just know you’re kind of later in the transition, you know, maybe go three months, four months.  and then you’ll have more likely women will experience those typical symptoms that we think about. Palm flashes and night sweats that don’t dryness.

So why, I think this is important just to highlight, why? Why are we not talking about this? Well, first, there’s just a lack of training. As I said earlier, there was a recent study that a lot of OBs said that they got maybe an hour of training on how to support menopause, not even perivenopause. So, I always tell my patients who come in, they’re so upset because they feel so ignored and not heard by their doctor that their doctors are probably pretty well intentioned.

They’re just not educated.  there’s certainly a [00:18:00] lack of research and there’s an under representation of women in medical studies.  due to historical biases and also a lot of women have been excluded from studies simply because their hormonal fluctuations are just too hard to control. So let’s just not include them at all because men are much more stable.

And I think it was only in, up until, I might be butchering this, it’s like the early 90s when women had to be included in studies for,  medications to be approved. So that’s all very recent. What doctor do you see? Seriously, if you, if you’re depressed, you’re anxious, you’re having heart palpitations.

You’re irritable, you have headaches, I mean, who do you schedule with? There’s not really one central hub of a person. So that’s why so many people see their therapist, a nutritionist, their primary, a neurologist because they’re getting headaches and tingling, a cardiologist because they’re getting heart palpitations.

And women don’t feel heard or answered. And then there’s simply a shifting narrative. Our narrative of aging has changed. We are not [00:19:00] just going to slow down, right? It’s the 50s, it’s the new 20s, like we, we’re not slowing down, we are active. And our, so our expectations of ourselves We’re not willing to slow down, but there’s just no support, really, in the medical, conventional medical community of how to keep up with that changing narrative.

I just think this is really important because there’s so many symptoms associated with perimenopause. So the most common one are period changes. It’s one thing you can ask from your clients, like, have your periods changed? Some people don’t know, which is why it’s important to track your cycle so you can begin to see mood changes.

Over 70 percent of women experience mood changes during perimenopause. And there was a study that came out a few years ago. They actually studied the term I don’t feel like myself. I mean, how many times have we heard that from our patients and clients? I don’t feel like myself. This was actually studied, I think it was published in Menopause.

I don’t actually know what exactly it was, but it was studied, I mean published, but they studied that and over 70 percent of women [00:20:00] said I don’t feel like myself more than 60 percent of the time over a 12 week period. So, it’s really common. And then so we have the period changes, the mood changes, And then the menopausal symptoms like hot flashes and night sweats and vaginal dryness.

But these other ones are important, and we’ve touched upon them, but less resilient, more irritable, mood swings, heavier menstrual cycle, irregular cycles, tender breasts, headaches, fatigue, brain fog, we, I know we’ve heard that, right? Lack of focus, forgetting where you put things, decreased libido, anxiety, weight gain, worsening PMS, hot flashes, dry skin, changes in body odors, bloating, insomnia, night sweats.  Burping, constipation, worsening allergies, ringing in the ear has been associated.

Dr. Weitz: I thought weight gain was caused by Ozembic deficiency. Ha ha.

Dr. Maggie Ney: Rowdy nose, post nasal drip, hair thinning.  hair loss, more facial hair, heart palpitations, achy joints, [00:21:00] frozen shoulder, right, things that come up in, you see it more in menopausal period, menopausal women, burning tongue is another one, more frequent vaginal infections like yeast or vector vaginosis, not recovering as well after exercise, itchy skin, problems in skin sensations, dizziness, and electric shock sensations.

I list them out because there’s so many. And I always say, like, you need to go get worked up and other things ruled out, but once you do, then you focus on the peri.  and so perimenopause is a clinical diagnosis based on symptoms alone and ruling out other causes. It’s really important because I see people come in, they say, my doctor took my blood and it’s normal, so I’m not in peri.

How often have we heard that, right?  our hormones just fluctuate too much throughout the cycle and cycle to cycle to really be, it’s just, it’s just not based on labs. So we can do a [00:22:00] blood test and rule out peri. You can certainly do a blood test and I think there’s a later slide and it’s suggestive of perimenopause.

We’ll get into that. But, it’s really based on how are you feeling, tracking your cycles, recording your symptoms, and then labs to rule out other causes of your patient’s symptoms. So the main ones, right, that overlap most of the ones, of the symptoms I talked about, are your thyroid, anemia, and autoimmune disorder, vitamin D, B12 deficiency.

So conventional guidelines, true, perimenopause. Hormones change throughout the month and throughout the day, and this is all true, and I share that with my patients. But! There’s really no controversy about testing hormones for fertility, right? Our patients go day two, day three of their cycle, get their FSH tested, maybe get an AMH, get an estradiol, and that speaks to their egg quality, right?

If you do fertility, you’re familiar with it. If, like, this third day of your cycle, your FSH is high, that’s saying low, poor egg [00:23:00] quality. So Anyway, you can kind of extrapolate from that, that maybe you’re more in, in the period zone. But, normal hormones, normal other labs do not exclude perimenopause. They simply provide a little bit more information.

Okay, so, basically, things that are suggestive of perimenopause, but not diagnostic.  and again, I, day 2 or 3, if your FSH is above 10, it could be suggestive. Estradiol above 60 with an FSH could be suggestive of perimenopause. And AMH under 1, suggestive of perimenopause. And then as long as you’re getting those basic, you might as well get a baseline of your other hormones too.

And this is through blood.  Okay, I think I said that. So, oh, so what hap This is important. The definition of menopause is, is, I think, horrific. Right? It’s based upon if you’re getting your period. There are so many women who don’t get their period. Either they have an [00:24:00] IUD, or they don’t have an IUD. They have a hysterectomy.

They have an ablation. So how do you know if you’re in menopause? Well, it really doesn’t matter, right? Menopause is just that one day. But what are some, what are some suggestive? So an FSH above 35 and an estradiol less than 20 on two separate occasions is suggestive of menopause. An AMH less than 0. 2 is suggestive of menopause.

Speaker 6: The slide before, you said it was FSH above 10, but an estrogen above

Dr. Maggie Ney: Yeah, so basically, it used to be that we just checked FSH. And so, if your FSH was a seven, that would be great, you’re good, you’re not impaired, you shouldn’t get pregnant, you know, from a fertility perspective. But, because estradiol, which is released by our ovaries, is the, is the hormone that the brain picks up, To say it doesn’t need to make FSH.  So FSH is the hormone the brain releases to tell the follicles of the ovaries to grow to make [00:25:00] estrogen. So during perimenopause, when things are a little erratic, our estrogen can actually be high on the second day of our period when it really should be low. And if it’s high because of just being in perimenopause and lower egg quality, then it can falsely lower that FSH.  Does that make sense? Yeah. Okay. That’s true.  I mean, this is just comprehensive blood work that I will do if someone’s in, you know, who’s seen me, who’s not, I don’t feel like myself. So, basics. And then we have the Dutch test, which,  I wanted just to give a shout out to. And again, just another way to assess hormones and how you’re metabolizing hormones.

Speaker 7: Yeah, we didn’t quite get that. Oh, sure. Okay.

Dr. Maggie Ney: So basically,  I can talk [00:26:00] about this for a second, but CDC, you want to look at ruling out anemia, your metabolic panel, that’s the basics, your glucose, your electrolyte, your liver, kidney function, basic lipid panel, maybe you guys know, in functional medicine, we’re often doing more of the detailed lipoprotein particle size, but just the basic lipid panel.

Inflammation with your HsCRP, your SED rate, homocysteine is, again, a marker for vascular inflammation. I like always to get a fasting insulin for a metabolic health marker. Your hemoglobin A1c, which is that three month average of blood sugar. TSH is the overall thyroid health marker.  Free T3, Free T4. Sometimes I’ll order the antibodies.  Sometimes I’ll order the reverse T3. Not every single person gets that. A vitamin D, a magnesium, maybe 12, a folate, ANA if you’re presenting with more of those joint pains, and,  fatigue even, and then the hormone testing that we’ve spoken about. I didn’t mention this, but progesterone is a hormone that’s only produced when we [00:27:00] ovulate, so it’s always going to be really low that first few days of your cycle.

You know, if you get your hormones done day two, three, your progesterone’s always going to be low. So, you only produce progesterone after you ovulate, so just the last two weeks of your cycle. So, if you want to get an idea of where your progesterone is, you would time your Dutch test, you know, a week before you expect to get your period, or a week after you ovulate, or you would do your blood test, again, a week after you ovulate, or a week before you expect to get your period.

Dr. Weitz:  I just wanted to point out, for patients where you’re not sure where they’re at, their hormones are fluctuating, Dutch offers a cycle mapping, so you can test your hormones every day, during the course of a month, and kind of see what’s going on.

Dr. Maggie Ney: Yeah, so if you’re a period, you can see some of that more erratic estrogen.

Speaker 7: Yeah? How about if someone is already in their menopause and you want to talk to tweak their hormones? I mean,

Dr. Maggie Ney: personally, I don’t, I go by symptoms. I go by symptoms. If they’re in menopause, they’re not bleeding, I [00:28:00] go by symptoms, I see how you’re feeling, and I might do a blood test to make sure your number’s, number’s not too high, or if they’re not feeling optimal and their levels are very low, then I’ll increase.

Speaker 6: For the Dutch panel, do you order that at the beginning of treatment or is it like, throughout treatment? I don’t,

Dr. Maggie Ney: I mean, I think the Dutch panel is amazing. I don’t necessarily order on every single person, to be honest. It’s not mandatory.  I do discuss it with my patients if they’re curious to dive a little deeper or if they’re having any of the symptoms that I think I would need further support with looking at the,   Metabolizing hormones.

But I would say I like to, when I, I, I think if I’m going to like choose a time to do it after they’re on the hormones. ’cause I want to see how they’re metabolizing the hormones and make sure they’re going down the good pathways because you can feel amazing. It’s true. And still be maybe pushing it down before pathway, right?

For hydroxy estro pathway where you would want to do some more antioxidant work and try to push more towards the two pathway. So [00:29:00] I, if I get them stable on a good dose of hormones and I then I really want to dial in on.  for their support of how they’re metabolized, because it’s not just about how much hormones you make that control how you feel, but it’s also how you metabolize and clear hormones.

So let’s talk a little bit about hormone therapy, because there’s so much confusion. So let’s just get really clear on a few things. HRT stands for hormone replacement therapy, and it’s an umbrella term. It includes bioidentical hormones and synthetic hormones. And so, bioidentical hormones, I mean, I think it’s, it, it has been considered now kind of a marketing term.  That’s what a lot of the conventional doctors will say. It’s marketing, and, and I sort of agree, but it does, it does have a meaning. It means that the hormones have the same molecular structures as our own hormones. And they

Speaker: don’t come from

Dr. Maggie Ney: horses. They don’t come from horses, right, like primarians, and we’re going to talk about that.

But, oh, I mean, I need to, no, that’s a legal question.[00:30:00]

So HRT is the umbrella term in cough. It stands for hormone replacement therapy. Technically, when you’re talking about using hormone therapy for perimenopausal women and menopausal women, the correct terminology is MHT, menopause hormone therapy. Hormone therapy is another term that is kind of the correct usage and the reason usage because HRT technically is about replacing lost hormones.

So if you’re 27 and you’ve gone through early menopause, premature menopause, then you would be on HRT. You would be on a much higher dose of estrogen to replace it. But we’re really using low dose hormone therapy, and it’s a technicality like tomato tomatoes, but I want you to be aware of it because it’s slowly changing.

when people are talking about hormone therapy. So HT is used a lot, like hormone therapy,  ET, EPT is estrogen and progestin gin. So progestin gin is another umbrella term that includes [00:31:00] bioidentical progesterone or,  progestin. So it’s an umbrella term. And then BHRT is bioidentical and then, you know, HT, HRT, MHT are often used interchangeably.

So synthetic hormones, they’ve just been chemically older. They’re not identical. To human hormones.  so let’s just talk about what are some examples of the synthetic hormones. So there’s Premarin, which is what Ben was just talking about, conjugated equine estrogen.

Speaker: Come about? Let’s give, , horses hormones to women.

Dr. Maggie Ney: Well, okay, it actually came about because they used to,  grind up human ovaries to start, and then they would use pregnant women’s urine. And that was got, like, you can’t produce so much of it, so then they, the horses were the next one, so.  Oral birth control pills, it has ethanol, estradiol, which is a synthetic estrogen.

[00:32:00] A marine IUD contains a synthetic progestin, right, it has the levonorgestrel. And, I mean, this is nitpicky, but it’s true, just because something’s synthetic doesn’t make it natural, right? Horse urine is, it’s still natural. I just, I’m just putting, it definitely elicits the ick factor, but as we were talking about correct terminology, it just means that it’s chemically altered.

It’s not identical to our own hormones. And then bioidentical has the same molecular structure as our own hormones. So, bioidentical hormones are plant derived, so they’re made from soy or Mexican wild yams. They’re converted into hormones in a laboratory that have the same molecular structure as our own hormones.

There is no soy or yam in the final product. But because bioidentical hormones look and behave like our own hormones, They can naturally integrate into our own body’s physiology to help restore hormones balance better.  and then there’s, and this is important. There are [00:33:00] FDA approved bioidentical options, meaning you can get them at CVS and RiteAid bioidentical hormones or compounded hormones.

So let’s talk about the FDA approved bioidentical hormones. This is an area, I’m telling you, people are really confused. They want to talk so much about, I want to go bioidentical, I want bioidentical. I see patients come to see me. Asking for bioidenticals, and I say, what are you on? I’m on the patch. I’m on the estradiol patch.

That is a bioidentical hormone. So, again, it’s about just clearing up the misinformation, educating our patients, and together coming up with the best choice for them. So FDA approved means the hormones are evaluated for safety and effectiveness. All the FDA approved bioidentical hormones are dispensed with package inserts, containing extensive product information with detailed risks, potential side effects, they’re commercially available, you can get them at any pharmacy.

And so, some examples of FDA approved bioidentical hormones that are available right now are the estradiol [00:34:00] patch, the gel, there’s a spray, there’s a ring, there’s an oral tablet, there’s vaginal estradiol cream that works locally, not systemically, there’s progesterone capsules, and there’s DHEA vaginal inserts.

So those are all the bioidentical, FDA approved. So let’s talk about the compounding hormones. So the advantages of using compounded, they allow for different routes, dose, formulations. They’re just not available through a regular pharmacy. You can,  allows for products with the fewest ingredients. So commercial products tend to have more inactive ingredients.

I will say, like, vaginal estrogen is so important for women, like, everyone should be on it as they go through menopause because most, I think, 100 percent of women have some sort of vaginal dryness that can affect the genitive urinary syndrome, right? More frequent urination, more prone to UTIs. [00:35:00] And I prescribe vaginal estrogen all the time.

It’s definitely underutilized, but the commercially available one has parabens in it. It just does. And I I don’t, it’s one of those things when I talk to people or I’m out in the medical community, it’s like, it’s so underutilized. It’s like taking food away from starving children and saying, oh, but it’s not organic.

It’s, it’s kind of like that in my mind, so I want it out to everyone. I, but to savvy functional medicine practitioners, like, that’s just something to be aware of, that the vaginocin does have parabens. So I will let my patients know. I mean, some of them don’t care, you know, that’s fine. And some are like, I do everything I can to avoid parabens in my skincare, so can we get this calm?

 and then if you have like,  mast cell sensitivity patients, people who have really reacted just to everything, then I go towards the compounding pharmacies. So what are the common compounded hormones? So we’re going to talk a little bit more about testosterone, but there is no FDA approved testosterone hormone for women.[00:36:00]

So you can get a compounded. Estriol is a weaker form of estrogen. It’s great for vaginal dryness and there’s some great studies on it. Sometimes I’ll get compounded estrogen and testosterone. We talked about how everyone should be on estrogen cream, but there’s a boatload of androgen receptors in the vaginal tissue that respond very well to testosterone.

 there’s VIAS, which was really popular after the Women’s Health Initiative study, if you remember all that study that came out in 2002. We can talk more about that if you’re curious. And then progesterone capsules, the pharmaceutical ones, have peanut oil, so you can get it compacted without peanut oil.

You can get a sustained release, because it helps with sleep. So, you know, some people are like, I’ve been sleeping better, but gosh, it’s not lasting through the night. Then I’ll think about using the sustained release. So what are the FDA approved indications for hormonal therapy? That means there is no controversy.

Like, you can just go ahead and do this. You don’t have to, you don’t need a consent form. You don’t have to be worried about anything. If you’re [00:37:00] struggling with any of these symptoms, this these are FDA approved reasons for using it. If you’re having hot flashes and night sweats, low bone density, so if you’ve been diagnosed with osteopenia, the hormones are FDA approved for that.

Premature hypoestrogenism, that’s just if you go through menopause before age 50, everyone should be on hormones. And then genitourinary symptoms, so vaginal dryness, painful sex. Urinary frequency, frequent urinary tract infections these are all the FDA approved indications. But, hold on, we know from a lot of studies that hormone therapy can, these are studies to support it, can help with your mood, sleep, brain health, joint health, quality of life, and prevention of heart disease.

That is well known, and heart disease is the number one killer of women. So if we’re talking about FDA approved indications, do you know what’s most prescribed for hot flashes and night sweats? Do you guys know? SSRIs. And it’s an off label use of [00:38:00] SSRIs is to treat it for hot flashes and night sweats.

Depression that comes up during perimenopause. What’s the root cause? Probably the hormones, right? Oh, wait, wait, I just complained. So during perimenopause, as your depression, anxiety, more likely to happen, what’s most likely prescribed?  SSRIs. But, but, the root cause is hormones. But the thought of using hormones to address depression or anxiety during perimenopause is like the craziest thing.

Reckless thing because it’s an off label use. We use off label use of medications

Speaker: all the time. It’s being used for IBS. Yes,

Dr. Maggie Ney: yes Okay,

Speaker: so

Dr. Maggie Ney: These are symptoms where you think, maybe I’ll use some estrogen. Hot flashes, night sweats, depression, anxiety, irritability, brain fog, low libido, joint pain, menstrual migraine, super common. If someone gets a headache right around [00:39:00] ovulation, because we said there’s that little dip of estrogen, right before the period, on the first few days of your cycle, A little bit of estrogen can just kind of buffer that dip and can be, , make a profound difference for people.

 any skin changes. Oh, I’m so itchy, burning tongue, ear ringing, or any of the genital urinary syndrome, like any of the vaginal dryness. or urinary tract symptoms, you would think estrogen.

Speaker: Why is it known as atrophic vaginitis? This is a horrific

Dr. Maggie Ney: name.

Speaker: Oh,

Dr. Maggie Ney: okay. Atrophy. I’m sorry, can we just say men get ED as their rebranding?  From impotence to ED, right? Did you? That was like the most brilliant marketing campaign. But we got the suits, we got ED, right? No longer impotent. Like, that sounds horrible. Women go from atrophy, like they, I mean, to vaginitis. GSCAB, basically. It’s not quite as great as, like, Impotent to eat, but anyway.  So [00:40:00] again, these are things we’re thinking of using estrogen therapy for.  If you have a uterus, you always need to have a progesterone to be with it to,  protect the uterine lining. Yes?

Speaker 6:  for as far as, was there something that changed last year where insurances can cover, like, different diagnosis codes for, like, just primarily hormone deficiency or no?

Dr. Maggie Ney:  you mean to cover HRT?

Mm hmm.  HRT is usually covered by insurance. Like, it depends on your insurance if you use the commercially available ones.

Speaker 6: We’re a cash pay program, but, like, for patients that are applying for reimbursement, we’re just curious about doing that. If we gave them, like, a diagnosis code, could they

Dr. Maggie Ney: use that?

Oh, for hmm.  to get it through what, like, CVS?

Speaker 6: , so they pay, they pay us a membership fee for it, and we do, we do repellent screens, injections, and then all the labs, it’s like all included in the membership, the physician visits and stuff.  but I didn’t know if there was like a go [00:41:00] to ICD 10 code that you could use for them to submit that for insurance.

Dr. Maggie Ney:  I don’t know for sure. I think, yeah, I don’t, I don’t know actually to be honest with you. I think,  yeah, it’s a, it’s a subtle question. I know what you’re asking, but I don’t know. You can get

Speaker 6: to the fillable codes

Dr. Maggie Ney: to get it covered,

Speaker 6: just for the hormone deficiency, rather than

Dr. Maggie Ney: like those specific ones.  I mean, there are for office visits, but as far as medications, yeah, I’ve never had like a prior authorization for hormonal therapy. It’s just, it’s just covered. Okay. Not through compounding, but through, okay. So, progesterone, Progesterone. We know that the function, it helps prepare the uterus to accept an embryo, it protects the uterine lining from this unopposed estrogen, which can increase risk of getting,  dysplasia and initial cancer.

Progesterone is anti inflammatory, it’s [00:42:00] immunomodulatory, it inhibits urine contractions, it has a calming effect in the mind. You take it orally, it’s converted into the liver, into allopregnenol, which binds to the GABA receptors, so it does have that calming effect. And it does slow the gut, it can help with sleep,  causes of low levels, well, perimenopause and menopause.  And then the symptoms, we said it a little earlier, but really when you’re thinking perimenopause, you’re thinking your periods are coming a little closer together, multiple in a month, heavier cycles, spotting, insomnia, and anxiety.

Speaker: Do you ever just use progesterone for when you don’t want to take estrogen?

Dr. Maggie Ney: Yes. I do.  There are actually studies that say higher amounts of progesterone can help with cough flashes at night’s wise, like upwards of 300 milligrams.  but sure,  definitely for like the anxiety and the sleep, progesterone can be great. Sometimes I’ll use progesterone on testosterone and not the estrogen.  But let’s talk about testosterone. Testosterone is the most abundant hormone in women. We have more testosterone than estrogen. Plays a key role in muscle mass. Bone [00:43:00] health, confidence, and burning fat keeps our metabolism strong, our libido high. It does start to decline in our 30s, and 50 percent of women’s testosterone levels have been lost by menopause.  So some symptoms of having lower testosterone, low libido, lower confidence, difficulty with orgasms, fatigue, less muscle mass, and difficulty building muscle.  So testosterone therapy. So it’s not FDA approved for women, which is crazy, but it’s just not. Even though there is supporting evidence, we do need more research, but there’s supporting evidence for sexual desire, mood, confidence, energy, vitality, muscle health, possible adverse effects with testosterone. It is too much for your patient’s body.  You can have some acne, hair thinning, increased body hair, anger, irritability. for listening. But it is endorsed by a number of organizations to treat women who [00:44:00] experience, and this is the clinical diagnosis, is hypoactive sexual desire disorder,  in postmenopausal women, which is basically low libido that bothers you.  Alright, so if you have low libido, but it’s not really bothering you, and it’s not bothering your relationship, that doesn’t, you get the definition because it has to be upsetting to you.

Dr. Weitz: Let me just ask, progesterone is available as a supplement. What do you think about women who use something like that?

Dr. Maggie Ney:  yeah, it’s available as a cream, topical. Yeah. I think if you’re using it during perimenopause, that’s fine to see if it helps you, but I would not use cream to protect the uterine lining if you’re postmenopausal on extra due.   So DHEA, it’s also a hormone. It’s a bioidentical hormone, DHEA.  it’s produced by the adrenal glands. It starts to decline in [00:45:00] our 30s. It decreases by an average of 60 percent by the time of menopause. And DHEA is a precursor hormone. Our body turns it into testosterone and estrogen. Our vaginal and vulva tissues are loaded with estrogen and testosterone receptors.  Thanks. So, giving DHEA vaginally can be really effective, because then intracellularly, it’s converted into testosterone and estrogen. And again, there is one FDA approved, it’s called IntraRosa, DHEA that you can get through the pharmacy, but again, you can get it compounded as a DHEA. You can even take DHEA capsule at low dose and insert it vaginally.

Dr. Weitz: Do you like that Bezwecken cube?

Dr. Maggie Ney: I just, I learned that from you. I don’t have much clinical experience, but it sounds good.

Speaker 7: What do you define as low dose?

Dr. Maggie Ney: Like for, okay, so the studies say 6. 5 mg, so that’s like the commercially available one, so you either get it compounded, you can’t really, you can’t find 6.

5 mg, which are, you know, you just have to [00:46:00] see. Just a capsule, like the gel capsule you just A little gel capsule, I don’t, it’s more than dissolved. Instead of swallowing it. Yeah, instead of swallowing it, you can do it vaginally.  you just have to make sure it dissolves, so I would think a capsule may be better than a gel, but I could be wrong.

Just, as long as it stays in you, it doesn’t fall out.  so, yeah, there’s not a tremendous amount of studies, but there are some, and it’s safe to try, it is. I usually test women, and if they’re lower than 100, then I’ll start them on like 5 or 10 milligrams, just to see if they, they get a little better, and I have seen an increase in testosterone levels in the blood.

 So, bioidentical, I mean, I’ve said some of this, but,  here are the treatment options for estrogen that are bioidentical. You can get the patches, estradiol patches, estradiol gels, there’s estradiol tablets, there’s a vagal cream, a vagal tablet, there’s rings, and then you can get a compounded estradiol cream.

 and then we talked about estriol, which has, in the past, been paired with [00:47:00] estradiol in a form of bias. I really don’t do that much anymore. That really came out when we were scared of estrogen. We were scared of estrogen after the Women’s Health Initiative. So we came out with this bias because you can have estrogen and estriol, and estriol has a little estrogen effect.

So you can maybe reduce the estradiol and have more estriol, but estriol doesn’t have the studies to support the heart health and the bone health. So,  I just don’t think it’s needed. Our liver converts estradiol to estriol, so if you’re doing the estradiol, which has the potent effect, and give liver support, then your body’s turning it into estriol.

And then again for progesterone options the commercially available is oral micronized progesterone, also known as Prometrium.  again, you can get it compounded without the peanut oil, sustained release, and then there’s crinum gel, which is an FDA approved bioidentical progesterone gel that is used for fertility and has been looked at a little bit for uterine protection too.

 you, like I said, during, when you’re [00:48:00] menopausal and not bleeding anymore and you’re on estrogen, you have to be on progesterone. Most women love their progesterone. It’s like, helps them sleep, it’s calming, they feel like a warm, cozy blanket’s covering them. Some women feel nothing, they just have to be on it if you’re uterine infected.  And a small percentage of women do not like progesterone. It makes them depressed, weepy, bloated. It’s a small percent, but it’s always good to educate our patients on that. And if that’s the case, and I say, put it internally, you can get your progesterone, just do it vaginally.  the other options are like the Mirena IUD can be used if you can’t take it.  and then there’s other hormone options as well. So, it’s always just, there’s always options, right? There’s always options.  okay, so for

Dr. Weitz: By the way, do you cycle the progesterone or do you give it every day?

Dr. Maggie Ney: I give women the choice. I do educate. There’s really no studies that say cycling is better or safer. I know intuitively that maybe for some people this feels right. Okay. To take,  progesterone to match your cycle, so I fully support [00:49:00] that.  But some women love their progesterone so much, why would I deny it for them the first two weeks, right? If it really helps with sleep and mood and anxiety. So, I educate people. Like, I teach them. You get, progesterone is produced during the second half of the cycle, so if you wanted to mimic the cycle, which some people really are, that feels right to them, I get it.  Then I’ll support them with that.

Speaker 7: How about the impossible?

Dr. Maggie Ney: I don’t routinely do it, but I give women the choice. Same thing. I do give women the choice. I don’t say you have to do it one way or one way is better. I know people have, feel strongly about that, but I see people love their progesterone, so I don’t want to be like, you can’t take it.

It’s better. I’m not, I don’t feel like there’s enough research to support that it is better. In fact, most studies are done, well there’s been some cyclical studies, but it’s really just what the patient wants. I educate. I do. So for testosterone if you wanted to use an FDA approved form of testosterone, then you would prescribe a [00:50:00] man’s testosterone that is FDA approved.

 they come in like 50 milligram tubes, and you would make that tube or packet last 10 days. It’s one tenth the dose. That comes to about a pea sized amount. Or you can put it in a 5cc syringe and use half a cc a day. I don’t usually do that, to be honest with you. I have, like, done it once for someone who really wanted it.

So I usually get it compounded for women. And so, like, the average dose for menopausal women is five milligrams of testosterone, but I’ll usually start, like, at one and work up to see how people feel. So these are all your options.  like, if you’re getting in the weeds of prescribing or helping women through this, It is important to know, like, all the different options, because I’ve had patients who can’t tolerate bioidentical progestin.

They just feel awful, and they need it, and they can’t do it vaginally. And I will then look at some of the combination patches, which [00:51:00] is a bioidentical estradiol with a progestin.  so I’ll try that, or if I do,  a tablet. I mean, there’s just options for people. You just need to, there’s pros and cons.

That’s good. And if anyone has any like specific questions about the pros and cons of any of these options, I’m happy to go through them. But it’s just being familiar, and I don’t think we should label things as good and bad. It’s just the pros and cons, and what’s

Speaker: right for people. But from a functional medicine perspective, which one would you prefer the most of the synthetic progesterone?

Dr. Maggie Ney: Oh, okay, so from a sexual medicine perspective, I think the IUD is great, you know, like at the levonorgestrel, IUDs, localized progestin therapy is wonderful. That’s what I would say. And then you can be on any dose of estrogen and you’re getting the uterine protection. That’s what I would say.  yeah, so you can move on.

 I’m looking at time. So, [00:52:00] I, we can talk about this if you guys are curious about how did we end up to a place when. There used to be, like, 80 percent of women were on hormones and then it dropped to, like, 2%, now it’s, like, currently at, like, 4%, less than 10%. And it’s the Women’s Health Initiative. So, this was the biggest,  study that was done to look at hormone replacement therapy, because prior to this study, which started in the late 1990s, Most women would put on hormones because they saw that, you know, during perimenopause and menopause, women just felt so good, and women seemed to be living longer, and it seemed to, they had all these assumptions from observational studies.

Women lived longer, had less heart disease, they were doing great. So they’re like, alright, well, can we endorse this as like,  preventative medicine? Can we just say all women should go on hormones? I mean, that’s a lofty statement. So they, , put up this study, the Women’s Health Initiative, mainly to see, not a normal example of hot flashes or night sweats, but to see, do women live longer?

And can, is heart disease preventive? [00:53:00] So, this was the first, you know, double blind, randomized, controlled study that looked at two different groups. It had women with a uterus and women without a uterus. So women with a uterus, right, we said you need to take that progestogen to protect the uterine lining, so they used Prempra, which was Premarin, that’s the horse, the estrogen from the horse urine.

And Provera, which was a synthetic progestin, which,  We, we, well, I’ll talk about it a little later, but it’s just, it’s not the best, it’s like the worst progestin to be honest. It’s not metabolically friendly, it’s not breast friendly. But hey, they were doing, I always give people the benefit of the doubt, maybe to a fault, but they were doing the best they can with the knowledge they had at the time.

And then women without a uterus just were put on Pramerane. And then each one of those groups had a placebo. Well, in 2002,  I’m like, was that, was any, was everyone here alive then? No, I think so. Okay.  2002, [00:54:00] I mean, it was huge. The study was stopped short because of, I mean, the daytime television was interrupted.

The NIH president came out and said, you know, we’re stopping this study, sure, women on hormone therapy need to get off of it, there’s an increased risk of breast cancer, heart disease, and stroke. Holy, I mean people were so scared, this is how everyone learned about it. No one looked at the study, there was no, no doctor looked at the study.

Patients heard it at the same time healthcare practitioners heard it, and it caused such a media frenzy. Every newspaper, every news outlet, this was all over the world, the world, everywhere. And this was, I would say, well, many other people say it, in fact,  I’m blanking on his name, but a little bit later,  the greatest tragedy to women’s health was this, because it got women who were doing very well off their hormones.[00:55:00]

And, like I said, before anyone could really look at the data, and we’ll talk about some of the flaws, people that were excellent candidates were taken off their hormones. Women that were 37 who went through premature menopause were taken off their hormones. It was very sad. So,  I’m just going to say what we found, and this is with the PrenPro group.

The women who just took estrogen actually did very well, but this is the PrenPro group. So this is where the, all the fear that came out was based on these numbers. So there were 47 additional cases of gallstones and gallbladder disease and I’m going to just, I put in parentheses the reason why we saw that and that was because of the oral estrogen that was used.

 there were 9 additional diagnoses of breast cancer at year 5. I’m going to just reiterate this because that’s what everyone is so scared of is the breast cancer piece. This was what was found just in the PrEP program. And the women who took PrEP aren’t alone, so just the estrogen. There was 18 percent less risk of breast [00:56:00] cancer.

So there was a decrease, a clinically significant decrease risk of breast cancer in the woman who took estrogen alone. Yet, we are so scared of estrogen.  so it was, if you look at it like this, it was the progestin, the provera part that may have been the trigger for the breast cancer. But anyway, not to say that those nine additional diagnoses aren’t significant, they are, but that’s, that’s the way the media came out, made it seem like every woman had risk, like you were putting yourself at such huge risk.

And again, it’s diagnoses. They had better, the women who were diagnosed had better prognoses. They did not die anymore. No one died. They just had these incidents, I should say. There were eight additional cases of pulmonary embolism. That’s because of the oral estrogen that was used. There’s eight additional strokes.

That’s again has to do with oral intrusion and the timing. That’s another important piece. Seven additional heart attacks. That was due to timing. Six fewer cases of colorectal cancer, five fewer hip fractures, and zero additional deaths.[00:57:00]

Okay, so let’s talk about, let’s break down what was the problems with the study. Well, the age and health of the women study, so 70 percent of the women study. were over 60. Well, that’s not when we usually start women on hormone therapy past 60. We usually start when women are having symptoms, you know, 40s, 50s, early 50s.

The average age was 63. 10 percent of the women were between ages of 50 and 55. We know now, through all the retrospective analysis,  that timing matters when you start hormone therapy. Only oral estrogen was used. We know that oral estrogen is more inflammatory, so there’s higher risk of POTS. strokes, and gallstones.

And then the type of progestin used. So only Provera was used, which is a synthetic progesterone. It’s not metabolically or breast friendly. Women who took Premarin alone had 18 less, 18, 18 percent less breast cancer incidence. So that’s like the [00:58:00] breakdown.

Not if you start within that first 10 years. So if you start within the first 10 years of menopause, much higher chance of getting You get all the benefits, and you can continue taking it to the day you die, and you don’t increase your risk. There’s a slight increase if you start hormone therapy past that 10 year mark.

So you can still start hormone therapy, but the conversation’s a little different.

Speaker: Are you aware of this new study that came out in the Metapod’s Journal? Women over the age of 65 taking hormones, women who were taking estrogen, lower risk of not only breast cancer, but other forms of cancer, lower risk of heart disease, lower risk of all cause mortality.

Speaker 6: Would you say anyone who has a hysterectomy should be on just estrogen? Like, is there a reason why someone would not want to be on just estrogen?

Dr. Maggie Ney: Oh, they, [00:59:00]  yes. If you have a history of like endometriosis, progesterone is really anti inflammatory. If you have endo, it’s really not just a hormone thing or a uterus thing.

It’s really systemic. There’s more inflammation. There’s immune modulatory issues. So I would like to get. progesterone for that. Anyone who has insomnia, anxiety, they would benefit from that. Even if they don’t have a uterus. I don’t, I don’t necessarily put everyone without a uterus on progesterone, but it’s like, why don’t they have a uterus?

And then looking at that as a complete picture, because if it’s like very estrogen driven and, like I said, like endo, a progesterone can be really helpful. So basically, HRT is safe and effective for the vast majority of symptomatic women when starting within the first 10 years of menopause. I’ve given it to people past that 10 year mark.

It’s just a different conversation. All the benefits of heart disease prevention,  is a little different. Ok, so, ok, the study came out in 2002, [01:00:00] and then there was all these retrospective post hoc analysis done that did not make the news, right? There was no, no, nothing written up about this really important finding.

In 2007, it was declared that, when you started, within the first 10 years of menopause, women lived longer, decreased mortality, so less likely to die from all causes. There was improvement in hot flashes in the 90s, reduced incidence of osteoporosis, reduction in diabetes. In 2013, there was another post hoc analysis.

30 percent reduction in mortality. Women who started 60s, no effect with regards to heart disease and mortality, but women who started HRT in their 70s, there was a little slight increased risk of heart disease. And then in 2017, there was a follow up post hoc analysis. There was reduction in heart disease, decreased mortality, decreased osteoporosis, and decrease in reduction in diabetes.

This was, yes, they were looking at the same people, and they were looking at the data. [01:01:00] They, remember the data, the results came out in 2002. They just said it as it applied to everyone. Now they’re like, let’s take a look at this study. Who are these people that had higher rates of strokes? Well, oh my gosh, they were all 72.

Wow, in fact, no one in the 50 year range had a stroke. So that’s what they were doing. They were re analyzing the data through a different lens. Also,

Speaker 5: too, it could be other factors as they’ve aged. Totally. If they’re not overall,

Dr. Maggie Ney: you

Speaker 5: know.

Dr. Maggie Ney: Yeah, I mean big argument is also that women who are on hormones get their mammograms more often too.

So you’re more likely to diagnose a breast cancer as well. Anytime

Speaker 9: you’re in a better mood,

Dr. Maggie Ney: you just do things better.

Speaker 9: You do things better. Absolutely. You remember stuff. Yes, you remember to schedule those appointments.

Dr. Maggie Ney:  So, timing hypothesis. So when you start HRT within the first 10 years of menopause, the benefits outweigh the risks.

We already went through all the benefits. But when it comes to heart disease and dementia, it’s timing [01:02:00] that matters.  so again, why are we afraid of HRT? When you start, hormones matter. The form of hormones matter. So again, oral, more likely to get a clot, the stroke, the gallbladder issue. And really, it’s come down to this is the current reasoning, argument is timing.

The timing hypothesis, estrogen gives the greatest benefit, the most cardiac and cognitive benefits when given early in the menopause transition. And the healthy cell bias hypothesis, estrogen offers the most cognitive and cardiac benefits when the cells are healthy to start, not when disease has already set in.

Speaker 7: Question between the pill versus the patch.  is it true that you get more protection when you take the pill For the heart and the osteoporosis, compared to the patch?

Dr. Maggie Ney: Not with osteoporosis, and then when it comes to the pill, there’s like a little bit more of a reduction in, I think, an LDL, but when it comes to heart disease, same outcome.[01:03:00]

Same outcome. Mm hmm.  this is just a little bit of a summary. Ideally, you can start hormones within the first ten years of menopause, but the sooner the better. I mean, why wait until you’re like eight years post, unless someone’s come to you. But like, most of the time, these symptoms, you Start early and just straight.

It’s the, it’s the best for the vasculature. If you have a uterus, you have to be on progesterone, and  consider transdermal estradiol first if tolerated because it’s less inflammatory, less risk of clots, and she may be on, be on it for the rest of her life. A lot of people are like, I like the, I like Aurora, I want to just take a capsule, and honestly, if they were on it for five years, ten years, I mean, most people are fine.

Less risk of a clot than if you take birth control pills. It’s less of a risk. But because women, and now ACOG, menopause society, say that you can be on hormones until the day you die, and we know clot risk already increases as you get older, why not just start transdermally if you’re open to it?

Speaker 7: How about

Dr. Maggie Ney: Let me finish and then I’ll…I just want to say here, [01:04:00] there’s not a This is true.

There’s no family history that’s a contradication to starting hormones. So, someone could be like, I can’t be on hormones Aunt Sally, Grandma Sue, and my cousin Beatrice had breast cancer. That’s not true.

Speaker 5: Yeah, I’ve had an aunt who had breast cancer, and as soon as I mentioned hormones, all my credibility is gone.

Because their MD has terrified them. He factored on some kind of estrogen suppression. But they won’t talk, they won’t even

Dr. Maggie Ney: know. That’s a little different. I was talking about family history, like mom. But personal history, that’s where things are shifting though. It’s true because, you know, so, so often now breast cancer is caught so early, you know, you get it younger and it is, it is considered a contraindication, you know, I’m, I’m telling you with a date, like, non controversial, like, I mean, this is just the facts now, there’s no family history, but breast cancer is still [01:05:00] traditionally, like, a contraindication, but You know, so much is caught early, and what?

So women are getting breast cancer and cured, let’s say, in their 50s, and then dying from heart disease earlier. Having painful sex, they can’t urinate, they’re seriously depressed. So, again, and I, I come back to, it’s shared decision making, it’s informed consent, it’s patients, if you give them the right information, in a safe place, can make the best decision for themselves.

So things that it would be helpful if you have a family that has heart disease, diabetes, osteoporosis, colon cancer, we know hormone therapy has. Helps to reduce that.  failing history of Alzheimer’s. So there’s been a study that if you have the ApoE gene allele starting estrogen early, the menopause transition seems to be neuroprotective.

But yes, we need more. There wasn’t a lot of research there. Who should not go? I’m just, this is like, we could talk about the nuances, but this is just the facts. Personal history of a lung clot or pulmonary embolism. A personal history of an unprovoked blood clot. So, unprovoked meaning you’re watching TV and [01:06:00] out of nowhere you get a clot.

Where it’s provoked, like you’ve had surgery or you’re in a car accident, that’s provoked.  if you’re homozygous or factor V laden, if you have a personal history of a heart attack, stroke, or if it’s stemmed in place, obviously if you’re pregnant, if you have any unexplained vaginal bleeding or untreated endometrial hyperplasia, if you’re actively undergoing chemo, if you have active breast cancer, and then that’s where I said the prior history of breast cancer.

It is a contraindication, but the conversation is changing.

Speaker 10: Is that lung clot due to oral estrogens? I mean, is, is Is, is that where that comes from, or?

Dr. Maggie Ney: It comes from, yeah, that you already have, like, you have to figure out why you had that in the first place, but, yes, if you have had a history of a clot, then, then hormone therapy is usually contraindicated.

If it’s not, if it was unprovoked, meaning, right, like, the clot that travels from the leg, like, what, what caused that to happen in the first place? Okay, I think this is the final slide. It’s the most important one, and I’ve said it a few times, but The patient and healthcare practitioner, their [01:07:00] team. And patients really should be the CEO of their own health.

Not everything is black and white, especially when it comes to period menopause and menopause care.  there’s nuances. And risk and benefits of hormonal therapy need to be weighed against quality of life. All of this needs to be discussed openly with the patient to make them feel supported and heard.

Is there anything else?

Speaker 9: That’s it. I

Dr. Maggie Ney: can take questions I can ask. This is where you can find me.  you asked about all this, I have to answer your pellets. So, they’re very popular. I don’t recommend them. We have a new practitioner in my office who does do them. We just had, I just presented with her,  kind of like comparing, contrasting, but honestly it’s not, it’s, it’s, it’s important that patients know there’s safe options, like there’s FDA approved insurance covered options.

They need to know all their options. A lot of times women choose a pellet because they didn’t get any answers from their healthcare practitioner [01:08:00] and they’re searching and searching. Someone mentioned pellets. They have it. It’s, it tends to give, like, more super, super physiological doses. There’s benefits to it.

I know women feel amazing on them, many do. I haven’t found that I’m lacking anything in my toolkit with therapies that I talked to you about. They’re

Speaker 5: bioidentical. So

Dr. Maggie Ney: they

Speaker 5: could have a

Dr. Maggie Ney: free Yes, and the downside, yeah, they’re, they’re no creams. You don’t have to worry about transferring a cream to someone else.

If you’re working with a very skilled practitioner, side effects are very little, but I’ve seen in my practice women who have super physiologically high doses of testosterone, I’ve seen voice changes, clitoral enlargement that are permanent, and I’ve seen people feel horrible and I can’t do anything to help them.

Because it’s,  it stays in you. You support them, you can help with liver detox, you can do all those things, but I don’t like a therapy [01:09:00] I cannot take back if someone’s having a side effect.

Speaker 5: They

Dr. Maggie Ney: have to write it out. Why, why do, I mean, there’s arguments. I have my, like I said, my new doctor in our office is doing them.

I just, why? I don’t know. I have safe, effective insurance cover options. My patients feel amazing. Like, I don’t, I don’t need to go there, personally.

Speaker: Yeah, I think that’s, that’s one of the complaints about pellets. You get them in, they’re, it’s too high a dosage. You have to wait for them rather than, you know, using other forms.

So you can slowly titrate up the dosage to get the desired effect.

Speaker 7: Right. Two questions. I’m sorry. So there are standard doses you can’t

Dr. Maggie Ney: For pellets, I mean, you have like one pellet has a certain milligram of dose, and you can, and so titrate up. Basically, yeah. So

Speaker 7: there is that option. Yeah, you can have

Dr. Maggie Ney: a low dose, you can have a [01:10:00] high dose, but even a low dose is, can be high.

Speaker: Or if you start with a low dose, now you’ve got to wait 90 days to increase the dosage

Speaker 6: Versus like cream, do you have a little more flexibility in the dressing? Because you

Dr. Maggie Ney: can, yeah. Totally, I just like to have a little, my patients have a little bit more control. Ooh, a lot. A lot more control. Oh wait, I, you had a question, yeah.

Speaker 7:  how often do you do mammograms on your patients that are on hormones?

Dr. Maggie Ney: I mean, generally once a year, one to two, every, every one to two years. And I like the Sonocini too, that, that’s out of network, but,  it’s a really detailed breast ultrasound, basically. Mm hmm. It’s a nice thing to pair with the Mammos.

Speaker 9: Yes? Are there, , like nutrient depletions to consider with hormone replacement, or like, lifestyle? How do you support your patients going through with lifestyle and nutrition, basically?

Dr. Maggie Ney: Yeah, I mean, that’s a huge part. And sometimes it can help just to get their hormones down so that they’re feeling better and more motivated.

But,  I mean, I do individualize it, but the [01:11:00] overall thing is like, real whole foods first. Get rid of the old processes, and then you can more tweak it. So I do work on upping protein,   upping fiber, metabolic flexibility, meaning if someone, someone should be able to fast a little bit, you know, and not feel dizzy and lightheaded.

And when you incorporate the higher protein, the less processed carbs, you can do that better. More easily switch from burning fat for fuel to burning sugar for fuel. So metabolic flexibility, blood sugar stability, and increasing protein are the three pillars. to supporting women during this time.

Speaker 9: Okay.

There’s not the same, like, you know, oral contraceptives we see, like, you know, B vitamin depletion. Oh, no, there is not

Dr. Maggie Ney: that seen. Yeah. Right. Okay.

I like to test with,  Dutch test to see. Sometimes I’ll go off by simping because they’re having a lot of breast tenderness and clots, but, you know, the tests don’t get, like, not everyone benefits from DIMM because it does lower serum estradiol [01:12:00] levels Boo! So, but if I see someone who is not pushing down the 2 pathway for phase 1 liver detoxification, and they’re heavily in the 16 or 4, I’d like to give it to them.

Implant?

I haven’t seen that a lot, I just don’t have a lot of patients that have been on that. So, but I would say really just to support gut health and liver detoxification would be huge.

 I know people really love it. I, I, I just haven’t gone there. I just, I don’t feel too comfortable with all the safety data. I just, I always say like, I’d like to learn about it. I’d love to get more studies. My patients feel so good. I don’t feel like I’m missing, that doesn’t [01:13:00] appeal to me to like add in my toolkit right now,  because my patients are just doing so great with everything else and, and there is some concern with using it.

And I am a little bit more conservative than maybe some other functional medicine doctors.  but I, , the principles of functional medicine like addressing root cause, gut health, liver correction deficiencies, I mean, I’m so passionate about that. But then I do, I am also a research junkie and I do need to, like, see some safety data before doing some of these other therapies to feel comfortable doing it.

Speaker 7: What is your therapeutic dose for, to start, for esrivalin for testosterone?

Dr. Maggie Ney:  it depends who I’m treating, but if it’s peri, like early peri, the depression, the irritability, they’re still getting their period, I do tend to start at the lowest of. So generally, like, if you’re doing a patch, it’s the 0. 025 milligram patch.

If you’re doing a cream or a gel, it’s the 0. 25. So I start low with the, with the early peri, and then menopausal or late [01:14:00] peri, I do typically start at 0. 375. Sometimes 0. 05, 100mg, but I’ll go up to 300mg sometimes.

Speaker 7: When you go up, can you go down afterwards? Yeah. There’s no

Dr. Maggie Ney: Yeah, go by how you feel,

Speaker 7: yeah. Do you give menopausal women a higher

Dr. Maggie Ney: dose?

Speaker 6: Typically, yes. Of estrogast?

Dr. Maggie Ney: I do.

Speaker 6: What is the conversation you have with your like mid 60 patients that come in wanting to start HRT? You said the conversation was a little bit different.

Dr. Maggie Ney: Conversation’s different with regards to benefits and risks. You’re not going to get this. It doesn’t seem to get the same cardiac benefits or cognitive benefits.

Your risk of getting a clot is higher,  in the first six months. Not forever. Really, it’s that first six months. We’re,  because our, like, the vasculature, our blood vessels do better when they haven’t taken a break from seeing estrogen. So if there’s any, like, plaque that’s developed, estrogen, which is normally anti inflammatory, can be a little bit more [01:15:00] pro inflammatory when given, you know, after that 10 year mark.

The risk isn’t huge. It’s just the, the, you’re going to have heart disease, the prevention of heart disease, the number one killer of women, I cannot say if you’re in their 60s.

Speaker 6: Probably no studies on this, but like, aesthetics wise, like, we have so many female patients that want to, like, improve, obviously, their skin, their elasticity, like, does that improve?

Is that a reason that, like, a 65 year old woman would want to go on it versus

Dr. Maggie Ney: Yeah, better to start younger before all the sagging and, I mean, there’s such a dramatic drop in collagen and elastin as we go through perimenopause and menopause.  yes, hormones are great for the skin, even topical estrogen, you know, if you use what you use for your vaginal area, just put a little bit under your eye, that’s been great.

There are some of those, like, telemed companies need that are now giving estriol face cream. Compounding pharmacies are making estriol face cream. But anyway, that wasn’t really your question, but yes, even just hormone therapy is good for your skin. Again, not FDA approved, but, you know, we can, something, it does help.

Speaker: And Dr. Del Rizzi [01:16:00] now is giving women in their 60s It’s in 70s or, you know, it’s protocol for patients with dementia or Alzheimer’s.

Speaker 6: Replacing that.

Speaker: What about for

Speaker 6: the osteoporosis? ,

Speaker: estrogen and progesterone.

Speaker 6: For osteoporosis, is it, would you have to have testosterone to see if it’s like a significant benefit with reversing osteoporosis?

Oh, estradiol

Dr. Maggie Ney: is only with, not osteoporosis actually,  to be honest, it’s, it’s, it’s osteopenia. Like, it’s not, once you have osteoporosis, maybe estrogen’s helpful, but it’s, it’s most helpful if you can catch it before osteoporosis. When you’re in osteopenia.

Speaker 6: What about testosterone? There’s

Dr. Maggie Ney: been no studies.

But, we know it’s good for muscle, and what’s good for muscle is good for bone, so, yes, we need that. But it is good for musculoskeletal, for sure, testosterone. It’s just

Speaker 6: like most women take estrogen [01:17:00] Left out to dry or like just left off? It’s horrible. We

Dr. Maggie Ney: forget about testosterone. It’s so important. You

Speaker 6: would put, like, recommend to all of them?

Dr. Maggie Ney: I mean, I never like to, I’m never like black and white like that. But yes, testosterone would be a nice thing to add to support bone health if you’re like osteopenic. But I always, with testosterone, it is a controlled substance, so you do need to do a lab test. Unlike estrogen or progesterone where you can really go by symptoms.

If you’re going to prescribe testosterone, you need a blood test.  you need to, and then you need to check again six months after, and then every six months thereafter. You can’t, you can’t prescribe it if your numbers are already high. That’s not right. For

Speaker 7: testing, so you start off with a block, and then do you do the dutch test every six months to see where they’re at?

Dr. Maggie Ney: I mean, I don’t. I think that’s a personal preference. I, I go, I really, again, I really meet the patient where they’re at and what they want.  I don’t know, my patients, some of them are very data driven and want the, lots of testing done. I go by how they feel, [01:18:00] I go and make sure their numbers are safe, you know, maybe a, a Dutch test at one point, I mean, some people say every year,  just to make sure they’re metabolizing everything well, but,  I don’t do a lot of recurrent testing if they’re feeling good.

Speaker 7: And, and when they’re on progesterone and estrogen, they shouldn’t be bleeding at all? No. So if they’re spotty, then

Dr. Maggie Ney: So if you start hormone therapy and you haven’t bled, you know, if you’re, and you haven’t been,  if you’re kind of post menopausal, anything can happen when you’re still peri, right? So let’s say you’re post menopausal, you start on hormone therapy, the first six months, you can bleed, it’s not a red flag, you know, we’ve always been taught post menopausal bleeding is a huge red flag.

You can bleed within the first six months, you don’t have to get nervous or anything like that, but,  that can just happen. But after that, then after that, you would want to work it up. And in which case, yes, sometimes lowering the estrogen or increasing the progesterone would help with that.

Speaker 10: Would you comment on testing topical [01:19:00] hormones during salivary testing?

Dr. Maggie Ney: Yeah, I mean, listen, you could talk to a number of different doctors and get a different response. I, I don’t do a lot of saliva. I mean, I rarely, I just don’t. That’s not what I do, but doctors do do it in love and independence. You kind of do what you’re used to doing. I don’t do the saliva. I tend to, well, use mostly blood.

Okay. I, I get the pros and cons of all of it.  I like the dutch test to add in to see how people are metabolizing and I go by how people feel. I haven’t found that I needed to do like a saliva test to tweak a dose or this or that. I, I haven’t had that issue. I hear my patient, I listen to their symptoms, I look at all their other markers, we do all the lifestyle stuff, so.

I don’t know, I think it’s a tough, you gotta be careful. There’s practitioners out there that really like, I don’t know, do all this testing, all this saliva testing, then I’m going to tweak your dose based on this and come in every three months. I just, I feel bad for the patients. Like, I don’t think it’s always necessary.

It’s like a money maker for the labs, for clinicians, but I don’t [01:20:00] really think it’s necessary. I feel bad. Patients need to know there’s options, right? You know, if a patient wants it, great, they don’t need

Speaker 7: it. How about women with hyperlipidemia? Yeah. Is there any contraindication that you No, in fact it can

Speaker 8: help, can reduce it.

Speaker 5: But my lipid numbers went up and in fact, had nothing to do with my food or eating. Oh sure, it’s genetics mostly. Yeah.

Dr. Maggie Ney: So I do like to have, especially for women like in her 60s and want to start a tournament, I’ll get a coronary calcium score. Let’s get a look and see the artery, the, any calcification.  Make sure that’s okay. You know, that, that’s what I would look at as we individualize and discuss risk. And so if someone has high, really high cholesterol it’s usually genetic and you know I like to look at the arteries of the heart to see if there’s any plaque deposits.

Speaker 7: Is that a,  that’s a,  scanning?  It’s a CT scan. It’s a CT scanning, right? [01:21:00]

Speaker 9: Yes? So I guess this is going off the same type of question but let’s say someone is over 60, you know, 10 years past. menopause coming in, would you personally say the benefits still outweigh the risks, or is it kind of dependent on the person? Yeah, I think they usually do what the patient’s

Dr. Maggie Ney: experiencing, but yeah, the risks are very still slim.

 


 

Dr. Weitz: Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast. I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues like gut problems. neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way.  Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111. And we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

Dr. Christy Sutton discusses How to Manage High and Low Iron with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

2:40  In part I of this interview with Dr. Christy Sutton, which was episode 347, we discussed the consequences of either high or low iron levels, the genes that increase the risk of high iron, and how to test for iron status.  Today we will focus on how to manage patients with either high or low iron.

3:09  Iron deficiency anemia.  There are quite a number of negative health consequences related to low iron or to anemia, including compromising brain function and development if it occurs during pregnancy or infancy.  In fact, lower iron during pregnancy is linked to ADHD, lower IQ, and autism risk.  Anemia technically means low red blood cells or low hemoglobin, of which iron deficiency is only the most common cause.  Iron deficient anemia can create fatigue. It can create cardiovascular problems because the heart’s having to work harder to get enough oxygen to your brain and the rest of your body because there are not enough red blood cells. It can lead to depression, which then gets treated with antidepressants.  If you have a patient with iron-deficient anemia, the first question to ask is why?  Do they have a malabsorption issue, a GI bleed, are they over-exercising, or are they simply not eating enough absorbable iron, which is the heme iron found in animal foods like red meat?  Do they have the celiac gene, which could cause malabsorption, or do they have some other digestive issue, such as SIBO or IBD or H. pylori or having had part of their digestive tract removed surgically, such as with gastric bypass surgery for weight loss of part of their intestines removed because they have severe Crohn’s disease?  Do they have low iron or low copper or low minerals or do they have heavy periods or uterine fibroids that are leading to blood loss or are they taking a bile sequestrant or a proton pump inhibitor like Prilosec? 

9:39  Pregnancy.  Women usually need extra iron during pregnancy, which doesn’t just create low iron, but low everything.  OBGYNs seem to be focused on the need for folate, but they often overlook the need for iron and many other nutrients. And just taking a modest supplement may not be enough for you. Ideally, doctors should test for nutrient status and then test again during the pregnancy to see if the supplementation is adequate, though this often doesn’t happen.  Dr. Sutton was told to take 30 mg of iron, but for her during pregnancy, she need to take 150-180 mg of iron per day for most of her pregnancy to keep her ferritin at a decent level.  Sometimes iron levels can go down fast into a dangerous zone and some women may need an iron infusion or a blood transfusion.  But while this may be necessary, this is not that great for your body, since such iron is unbound iron that is damaging because it will oxidize things and steal electrons.  The type of iron–ferrous peptonate–that Dr. Sutton likes is Hemo-Lyph from Nutri-West, which is very absorbable and doesn’t create as many GI issues.  This product also contains vitamin C, which increases iron absorption.  Dr. Sutton also believes that taking NAC with iron will increase iron absorption, though she does not find adding copper is helpful.  And to maximize iron absorption, do not take iron at the same time as calcium, alpha-lipoic acid, silymarin, vitamin E, or curcumin at the same time, and also don’t take your iron at the same time as drinking tea or coffee, since these can all interfere with iron.

23:25  High Iron.  At least 31% of people have at least one of the hemochromatosis genes that leads to them being more likely to store iron.  And there are also patients with hemolytic anemia or thalassemia who have red blood cells breaking apart and spilling iron and these patients have high iron but should not remove blood, because while they have high iron, they already have low red blood cells.  When clinicians start looking at complete iron panels and start looking for iron status, it is common to find that there are many more patients having problematic high iron levels from hemochromatosis.

27:24  Treating high iron.  If you have a patient with high iron and who does not have thalassemia or hemolytic anemia, then you want to remove blood by either donating blood or going to a hematologist and having a therapeutic phlebotomy.  The hematologist can remove as much or as little blood as is needed for that patient, but it can take a while to get to see a hematologist and it can cost more, depending upon insurance coverage.  If the ferritin is very high, such as over 1000 or 2000, then you may need to have blood removed several times to get it down, so going to a hematologist may be more effective, than a blood donation center that can only remove blood every six weeks unless your doctor signs a form.

35:30  Diet and Supplements. Curcumin.  Blood donation ideally should be used in tandem with changes in diet, nutritional supplements, and lifestyle.  Of course they should avoid taking supplements with iron and should also avoid high dosages of vitamin C, which increases iron absorption.  There are several nutritional supplements that can help to remove iron and they also have the benefit of being anti-inflammatory and helping to promote your health.  The most powerful supplement is curcumin, which lowers iron by binding to it and curcumin is not only anti-inflammatory but it is anti-cancer, brain protective, and heart protective. Dr. Sutton noted that many of her patients with hemochromatosis also have a lot of joint pain and curcumin helps with this by reducing inflammation.  Dr. Sutton usually uses a higher dosage of curcumin, such as 3 grams per day.  She likes a product from Epigenozyme called Inflam-Redux Turmero and she uses six pills a day of that taken with meals, spread through the day. 

41:25  Silymarin.  Silymarin from milk thistle also binds to iron and has been shown to reduce stored iron in the brain, the liver, and the spleen. In particular, silymarin is known to protect the liver health and it can also reduce benign prostatic hypertrophy and it can also increase sperm count.

44:32  Quercetin.  Quercetin does not bind to iron but it increases hepcidin, which lowers iron absorption.  And quercetin has lots of other antioxidant and health promoting properties, including lowering histamine, which helps with allergies and some gut problems. And since one of the negative consequences of high iron is high histamine and mast cell activation, then this can be helpful. And of course quercetin helps get zinc into cells for antiviral properties.

 

 

 



Dr. Christy Sutton is a doctor of chiropractic who published her first book in 2018 on genomics: Genetic Testing: Defining Your Path to a Personalized Health Plan.  She then diagnosed her husband with hereditary hemochromatosis, and high cortisol from a pituitary tumor, which she believes high iron contributed to.  Her new book is  The Iron Curse: Is your doctor letting high iron destroy your health, about the risk of high iron or hemochromatosis and the health consequences that can result from it.  Her website is DrChristySutton.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz:            Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website. drweitz.com. Thanks for joining me and let’s jump into the podcast.

                                Hello, Rational Wellness Podcasters. Today I am excited to be having a second interview with Dr. Christy Sutton on the importance of iron and iron overload. Part 1 was episode 347, and we focused mainly on the importance of iron, the problems with having too much iron as well as how to do the proper detail testing to be able to diagnose either low iron or high iron with an emphasis on the hemochromatosis or high iron. But we didn’t have time for treatment. So today we’re going to focus on how to treat patients with low or high iron.

                                Dr. Sutton is a doctor of chiropractic who’s an expert at genetics. Her first book was on genomics, Genetic Testing: Defining Your Path to a Personalized Health Plan. Dr. Sutton is also an expert at diagnosing and treating iron problems, especially high iron or hemochromatosis as well as anemia. Her new book is The Iron Curse: Is Your Doctor Letting High Iron Destroy Your Health?  Dr. Sutton finds that hemochromatosis or high iron is more common than most people think, and it’s often undiagnosed. High iron is also a topic that is really discussed in the functional medicine world and may be an underlying problem with patients suffering from liver, cardiovascular, or neurological problems. On the other hand, iron is an absolutely essential mineral is needed by nearly every organ in the body, nearly all the cells. In fact, I was just listening to a podcast by Dr. Peter Attia on my drive in here, and he mentioned that 2% of the human genome encodes for iron-related proteins, which is staggering amount, and that 6.5% of all enzymes in the human body are iron-dependent.  Dr. Sutton, thank you so much for joining us again today.

Dr. Sutton:          Thanks for having me.

Dr. Weitz:            Good. So as I mentioned, in part 1 we discussed the consequences of low or high iron. We talked about the genes that increase the risk of high iron and how to test for iron status. So today I’d like to focus on how do we manage patients with either high or low iron and perhaps maybe go through a few examples.

Dr. Sutton:          Okay.

Dr. Weitz:            Great. Why don’t we start with iron deficiency anemia? And we’ll spend most of the time on high iron. So iron deficient anemia is too little iron which can compromise brain health. Women often will have problems with not having enough iron during pregnancy, and this can lead to higher risk of developmental brain issues with children including ADHD, lower IQ, autism.

Dr. Sutton:          Yes, so there’s certainly a plethora of negative health consequences related to low iron, anemia. So technically, anemia doesn’t mean just low iron. It means you just don’t have enough healthy red blood cells or hemoglobin. There’s multiple different types of anemias. You could have adequate iron but still be anemic because you have low red blood cells or low hemoglobin. But if we’re just going to talk about iron deficient anemia, that is a common problem and it can look like fatigue. It can create cardiovascular issues because your heart’s having to work harder. Any anemia can make your heart have to work harder because now your heart has to pump faster basically to get enough oxygen to your brain and your arms and legs and your whole body because there’s not enough healthy red blood cells, not enough oxygen being carried. And so it can really just wreck your life, long-term health consequences and short-term.  And unfortunately, it’s I think being also misdiagnosed a lot. It could create a depression-type problem, and then maybe your doctor treats you with an antidepressant rather than… Just like low thyroid could create a depression-type problem and then you get mistreated. These are common issues that slight tangent of subject here, but in my opinion, psychiatric medicine could maybe have some room for improvement with ruling out other diagnostic issues rather than just using SSRIs or antidepressants, but that’s a tangent. But low iron is one of those things that can create a lot of neurological issues.

                                And if we want to focus on the treatment piece of that, then the hardest part of that piece is figuring out why you’re anemic. If you have iron-deficient anemia, why? And then ultimately you have to fix that and then increase, change your environment so that you fix the why on top of getting your iron levels back up. And so the why is the wild card.  And the most common reasons for low iron are blood loss, which is one reason that females tend to become anemic. So much more common than men. Although men can become anemic. If a man’s anemic, especially if they’re eating red meat, then you have to rule out do they have a malabsorption issue, a GI bleed, are they over-exercising? Even over-exercising in men doesn’t tend to create anemia type issues if they’re eating iron, but certainly vegan vegetarian diet will cause iron deficient anemia because the most absorbable iron is heme iron, which is only found in animal products. So this is why I could eat a pound of spinach and not get as much iron as I would and a couple bites of a steak because it has more iron in the steak and it’s more absorbable. That’s key.

                                So it’s not just the absorption. And you have to look at does somebody have… A big one now, it’s people that are taking PPIs, like proton pump inhibitors and they’re not absorbing iron or really other nutrients, period, because it’s all the acids being depleted in their stomach. That’s a big problem that causes low iron and low copper and other minerals and low protein and just malabsorption period. And then having any type of a GI bleed will cause low iron, whether it’s in your stomach. Do you have an H. pylori infection in your stomach that can cause it? Do you have a GI bleed anywhere in your digestive system, which is common? Do you have maybe a malabsorption issue from celiac disease that’s undiagnosed and untreated? That’s a common issue as well, which is one reason that I talk about the celiac gene and celiac disease in my book and talk about that. And then-

Dr. Weitz:            Even dysbiosis and SIBO will decrease absorption of nutrients?

Dr. Sutton:          Yeah, just I mean any digestive issue. Having part of your bowels removed or having the… It’s not as common now that people are losing weight other ways, but in the past when a lot of people were getting the bypass surgery to lose weight where they just kind of bypass the first part of your small intestine, that will cause low iron, low copper, low minerals because minerals are absorbed largely in the first foot of your small. So if you bypass that part, you’re going to have a lot of problems, which is one reason that they have so many issues.  And then certain medications like bile sequestering. Not a lot of people take those, but they will bind to iron. So there’s just a lot of factors. But probably the most common reason that I see low iron is because of heavy periods, malabsorption, fibroids. Women that just, they have uterine fibroids and they’re bleeding heavily. It’s just really hard to get enough iron to make up for this chronic blood loss that you’re experiencing.

Pregnancy is a great way to become low in iron because making a human being is very nutrient dependent, including iron and pretty much every other nutrient, which is why pregnancy doesn’t just create low iron but creates low everything. And then that low everything ultimately is a big part of the pregnancy complications and postpartum issues and even developmental problems in the baby.  Another side tangent. I wish that OBGYNs did a better job with the nutritional part of pregnant women. And I experienced that firsthand. I’ve seen that countless times in my own patient population. And they seem really focused on, are you getting enough folate? Which is important, but it’s like, “Well, there’s a lot of other nutrients that we need here too.” And me personally, when I was pregnant, I did become anemic and I went into pregnancy with, I think my ferritin was maybe in the 60s or 70s, which for me is a solid ferritin because I kind of have fought a low iron issue. So 60s or 70s is pretty good going into pregnancy. I knew it was going to go down. I didn’t know how fast.  So I took iron throughout my whole pregnancy, but around, I want to say week eight or week nine, I just did some labs on myself and I was like, “Oh, I’m getting lower. I need to take more iron.” And then a couple weeks later, the doctor did some labs on me and I was even lower, and they said, “Okay, you need to start taking 30 milligrams of iron now.” And I’m like, “I’m already taking 90 milligrams of iron.” So I think I ended up taking 150 or 180 milligrams of iron a day for most of my pregnancy, and my husband would have to just sit there and force me to swallow these pills because I was like… Because these iron pills smell so bad and I just couldn’t make myself do it. But his job was, I had this bag of vitamins I had to swallow every day. And it literally took another human being making me to do it because I was not otherwise going to do it. So anyways, but I’ve seen that time and time again with pregnant women.

Dr. Weitz:            One of the important things you just highlighted there is it’s often that a patient may be going into pregnancy, she might get tested once for iron and then just told to take iron as part of a prenatal, but rarely will they get tested again to see if it’s actually working or to what extent it’s working. So as we know in the functional medicine world, we’re big on testing. And the reason is because we need to see exactly what’s going on. We need to see the underlying cause. And then if we make an intervention, we need to see if it’s actually working, is it working too much, is it not working enough. And in order to try to save money, doctors tend not to retest.

Dr. Sutton:          Yeah. And unfortunately with iron in pregnancy, it can go down fast into a dangerous zone. And that’s where often women end up needing iron infusions, which an iron infusion is where they just inject iron into your blood, which is different than a blood transfusion. So a blood transfusion is where you get somebody else’s blood, there are red blood cells, hemoglobin. There’s iron in there, but you’re also getting the red blood cells and everything and the blood rather than just iron. And so a lot of pregnant women, they’ll need either an iron infusion or a blood transfusion depending on their situation. And there’s side effects to both of these, right?

                                So with a blood transfusion, you’re at risk for getting whatever. If somebody was taking a medicine or has a disease or toxic in something, then you just got their blood and now you have that in you. That’s obvious. We know about that. With the iron infusion, there’s side effects that are a little bit less known. People that have gotten iron infusions, some of them, they don’t feel a problem, but often they’ll have a bad reaction and they’ll feel really bad. And iron infusions always cause a lot of oxidative stress in the body because it’s unbound iron, it’s just free iron. And unbound iron is particularly damaging because iron is very reactive and it will go out and oxidize things and steal electrons. And it doesn’t do that if you absorb iron through your digestive system and then your digestive system binds that iron to a protein so that it’s protecting you from this potentially problematic iron that we need, but the body has figured out how to use it in a protective way.

                                And so the iron in the body without being bound to that protein is very reactive and creates a lot of rust oxidative stress in the body. So one thing that people need to do for the treatment part of this talk is if they are going to get an iron infusion, they really need to do a lot of antioxidants, vitamin C, glutathione, in my opinion, if you’re giving somebody a iron infusion, then give them some glutathione too or vitamin C later or before or whatever. Just vitamin E. All of these antioxidants have been shown to be protective from iron-induced damage. But circling back to other causes of low iron, we talked about-

Dr. Weitz:            So we’re talking about adding iron to somebody who’s low in iron. Is there a form of iron you like and then what other nutrients can be added or what can be done to increase their likelihood of absorbing the iron?

Dr. Sutton:          Yeah, that’s a good idea. So there’s lots of different types of iron. The one that I use in my practice the most is a ferrous peptonate form. The company that makes it is a company called Nutri-West. It’s called Hemo-Lyph. Why I like it is that it’s very absorbable and patients feel better. We’re using it. It doesn’t create as many GI issues. It doesn’t create the stomach pain and constipation like a lot of the other ones. And part of that is because of the form and because it’s highly absorbable.

Dr. Weitz:            What about the ferrous bisglycinate?

Dr. Sutton:          Hold on. I have to tell you the cons of the Hemo-Lyph first.

Dr. Weitz:            Oh, okay.

Dr. Sutton:          The cons of the Hemo-Lyph is that they do put folic acid in there, so you’ll want to take some methylfolate with it just to protect yourself from that folic acid.

Dr. Weitz:            Oh, okay.

Dr. Sutton:          But that’s kind of a side note. I don’t know why they do that. It’s weird, but you know. I have looked for and not found another one that I like more. And if I find one I like more, I’ll change to that. I don’t profit at all from that Nutri-West, like whatever. I think it’s a good company. It’s a family-owned company that makes good products, but I’m more than happy to change to another company if I find a better product. I just haven’t yet.  Now the ferrous bisglycinate, I’ve seen ferrous bisglycinate and used it in patients because sometimes people will want a non-animal source of iron. And the hemolyte does have some animal source in there, and that’s probably why so absorbable. So there is a ferrous bisglycinate product that I have used in some hardcore vegan vegetarians, and they do not do as well with it. So I have used it. It’s not my preferred. My preferred is the ferrous peptonate Hemo-Lyph. What I don’t like, which is most commonly found on the shelves and prescribed, is ferrous sulfate, which is not very absorbable. But okay, so-

Dr. Weitz:            That’s the one most often prescribed I think by AMDs.

Dr. Sutton:          Yeah, exactly. And so that’s the type. Okay, so then the second part of it, this question is, “Well, how do you take it?” Okay, the biggest problem people encounter when taking iron is it causes them either constipation or stomach pain. And then that is the number one reason that they don’t follow instructions for taking iron. So if you take iron with food, it is less likely to create that stomach pain. If you start getting constipated, then just lower to a lower dose. Sometimes people start getting constipated even with a really good iron source just because they’re getting too much of it, okay?  And if you’re going to take iron, then don’t take it around the same time as things that are going to bind to iron like calcium. Calcium binds to iron, this is one reason that young kids eat a lot of calcium tend to be anemic. But don’t take calcium around the same type of iron. Don’t take curcumin around the same time as iron. Any supplements that bind to in lower iron, alpha-lipoic acid, silymarin, don’t take those at the same time as the iron. Even vitamin E can do that to some extent because it can bind to the iron and render it less absorbable.

                                Don’t drink coffee or tea around the time that you’re consuming iron supplements or an iron rich meal because that will decrease iron absorption. If you’re taking a medication to lower acid or a bile sequester or something that’s going to lower iron absorption, try to take that medication away from your iron supplements, iron rich meal, that type of thing if possible. Or better yet, if you can fix the underlying problem, fix it. Why are you on a PPI for 20 years? Maybe that’s something that needs to be looked into.  So the when you take it and how you take it is very important. And then fixing the underlying problem, like are you a celiac patient that is going to chronically be low in nutrients if you don’t just get on a gluten-free diet or whatever? So that’s crucial. Was there anything that I left out there? Oh, some people get low in copper and that copper deficient anemia can cause iron deficient anemia too, which is becoming more well-known as people talk about it more. But in some cases people will need to take some copper with or in lieu of iron to help absorb iron better because if you’re low in copper, you’ll become low in iron.

Dr. Weitz:            Which is why I think you see some combination iron products designed to help improve red blood cell production. Include copper. Usually they throw in some vitamin C. Usually they throw in-

Dr. Sutton:          Yeah, I forgot to talk about vitamin C. But yeah, vitamin C will increase iron absorption. You’re totally right. That’s a great point. I have tried the products that have copper in them that Hemo-Lyph doesn’t have it in it, and they caused more problems in people. And then I tried it on myself and I had problems and I was like, “Forget about it.” But you have to find what works for you. And then taking vitamin C around the same time or eating vitamin C-rich foods, that’s a well-known way to increase iron. And then NAC can also do that, so N-acetylcysteine. If you take NAC around the same time as iron, then that can increase iron absorption as well.  And then just, I mean, I think really eating as much iron-rich food as possible. The best way to get your iron levels up is through your diet, you’re going to absorb that the best. And then it’s just a matter of if you’re a vegan or a vegetarian, are you willing and able to eat more iron in your diet that’s absorbable, which is probably going to mean veering away from that vegan vegetarian diet? And some people do that and other people are not willing to, and then you just try to walk the line. But it’s certainly can be a challenge for a lot of people, mostly women, mostly women in childbearing years because they’re menstruating. Postmenopausal women tend to not have as many issues with high low iron. And that’s where you see a lot of hemochromatosis women that say, “I have been low in iron. I can’t be high in iron.” I was like, “Well, yep, you’re not menstruating anymore. Sorry.”

Dr. Weitz:            So let’s go into high iron, which is I think fascinating topic. I had no idea there were as many people who have problems with high iron. And you mentioned in your book that at least 31% of people have at least one of these hemochromatosis genes, and that’s only referring to two of the genes, and there’s a third gene that’s usually not even mentioned. So we probably have more than 30% of the population as a propensity to absorb and store more iron.

Dr. Sutton:          Yes. Yeah. Have you started looking for high iron more or looking iron labs more?

Dr. Weitz:            Yeah. In fact, I just recently had a woman and her daughter and the mother is a vegan. She’s not a lifelong vegan, and her iron was sky-high, so were her hematocrit and hemoglobin. She was shocked and nobody even looked at that for her.

Dr. Sutton:          As a vegan, so does she have those genes?

Dr. Weitz:            We didn’t check the genes. I asked her to send me her 23andMe, and she was having a tough time getting the raw data because 23andMe is having all these problems with being hacked. Everybody’s getting hacked. So I don’t know, but her daughter also has a propensity for storing iron.

Dr. Sutton:          Yeah. Then statistically speaking, there’s a good chance. And you have to rule that out because the question is, why is this happening? And so yeah, that’s interesting. But yeah, as clinicians really start looking more, I think their eyes open to like, “Oh, this is a common problem that maybe hasn’t been on my radar and I haven’t really been looking at it properly.” And so as a clinician, it’s kind of like to me an easy fun thing because this is easy. And we get to catch something that could really damage your health and even your family’s health if you have that gene. And we get to catch it hopefully before it does. Or if it has already created issues like, “Well, we get to work on the steps to help support your health so that you get better” and you don’t have to actually find answers rather than just more diagnostic codes and more medications.

Dr. Weitz:            You [inaudible 00:26:02] complex the problem is this. I have an eighty-year-old woman who was having fatigue and her red blood cells and hematocrit were low. So the doctor right away said she needed iron, but he couldn’t put her on any iron because he had to send her to a hematologist. And that took months to get an appointment. And so I just put her on some iron and her iron came up, and then I realized her iron shot up really high. I looked back and I had her bring in her labs. For a while, she had a keratin level of 1,200 and nobody was seeing anything. So this is somebody who has a propensity to store iron. And now she’s had lower iron and nobody asked why. So we just did a stool test and she’s losing iron in her stool. So there’s an underlying problem. And this is, I think, the real message of functional medicine. Let’s search for the underlying cause and not just treat the symptom.

Dr. Sutton:          Yeah, totally. It would be interesting that ferritin could also be high from inflammation. That’s where you have to look at the full iron panel. I think we talked about that last time, but I’ve slept since then, so I will not go back to that. I’ll focus on the task.

Dr. Weitz:            Okay. Yeah, so let’s talk about… so we have a patient with high iron, and so the options of things to do involve therapeutic phlebotomy, changing the way they eat. And then you go through a bunch of supplements. And some of those supplements, you also have some great clinical pearls that I want to mention when we go through them.

Dr. Sutton:          Yeah. Do you want to start with the therapeutic phlebotomy or do you want start-

Dr. Weitz:            Sure.

Dr. Sutton:          Okay. So in the Iron Curse, I have the Iron Curse protocols, which is basically like five steps that you can learn about and use to help lower iron regardless of if it’s hereditary hemochromatosis or iron loading anemia, like a hemolytic anemia or a thalassemic anemia. If you have high iron and you want to lower it-

Dr. Weitz:            By the way, for anybody who doesn’t know what Dr. Sutton just said, that thalassemia or hemolytic anemia means you have some condition where your red blood cells are breaking apart and spilling iron.

Dr. Sutton:          Exactly. Exactly. And so those people can have low red blood cells, but be high in iron, and that’s called an iron loading anemia. So thank you for clarifying that.  So step one of the Iron Curse protocols is remove blood if you can. Not everybody can remove blood. So for example, if you have low red blood cells, low hemoglobin, you don’t want to remove blood because you’re anemic and you will only become more anemic if you remove blood.  By the way, I’m seeing this a lot. People are coming to me and they have low ferritin and their person they’re working with is telling them to go donate blood to help mobilize the iron, and then their health crashes afterwards. I don’t think it’s a good idea to be donating blood if you have a low ferritin. I think that’s counterintuitive. And there’s a reason that people’s health crashes after that because now you were already struggling and now you just made it worse. So as long as we’re talking about donating blood, I just felt like I needed to put that little pearl in there. There is a school of thought out there.

Dr. Weitz:            [inaudible 00:29:45]-

Dr. Sutton:          There is a school of thought out there that… And I’m having more people coming and asking me about this, and I’m like, “I have no idea why you would donate blood when you’re low in iron. That doesn’t make sense to me.” And the proof is in the pudding, tasting of the pudding, and you felt worse afterwards. So there you go. It wasn’t a good idea.  Okay. But donating blood for people with hemochromatosis or not even donating blood, just removing blood. So if you have hemochromatosis hereditary hemochromatosis-

Dr. Weitz:            What’s the difference between removing blood and donating blood?

Dr. Sutton:          Okay. So if you go to a hematologist and have a blood removal, it’s basically the same thing as if you go to the blood donation center and have a blood removal if you donate whole blood. The difference is the advantage to the hematologist is that they can remove as much as they want, they can remove more or less. The hematologists are also much more specific about testing the full iron panel and the CBC before removing blood. Whereas if you go to the blood donation center, they’re not looking at the full iron panel, they’re just making sure like, do you have enough red blood cells in hemoglobin? If you don’t, they won’t let you donate blood. So the hematologist is just looking at it more specifically for hemochromatosis patients, which is why it’s really a better option.  The downside is, as you mentioned, it’s hard sometimes to get into a hematologist, especially if it’s your first visit. It’s also much more expensive. If you don’t have a great healthcare plan or haven’t met your deductible, it’s going to cost a lot more. Whereas if you can donate blood, that’s free. But if you have some type of an STD or you’re taking a blood thinner or there’s some reason you cannot donate blood, then you can have blood removed to lower iron either by going to the hematologist and having them do it and then disposing of the blood, or getting a doctor to sign a form called a therapeutic blood phlebotomy form. And that allows the blood donation center to remove blood, and then they just dispose of it rather than give it to somebody else.  So it’s basically the same thing. It’s just if you go to the hematologist, it’s going to be more specific for hemochromatosis patients. Whereas the blood donation center, they’re not treating you, you’re a good Samaritan removing blood unless you go with that signed therapeutic phlebotomy and then they’ll remove the blood and throw it away. But you have to have a doctor sign that. They also-

Dr. Weitz:            What if you have a vampire doing it?

Dr. Sutton:          Yeah, I haven’t researched that. I’ll have to look up vampire on PubMed and hemochromatosis.

Dr. Weitz:            Sorry to throw you off.

Dr. Sutton:          But I bet it would work really well. But then you have the risk of an infection in your neck and you might have to take antibiotics because of the wound from the fangs.

Dr. Weitz:            Oh, yeah, there you go. Thanks.

Dr. Sutton:          So donating blood, removing blood, whatever, that’s going to quickly lower iron because there’s a lot of iron in your blood. And so when people first get diagnosed with hemochromatosis, whether it’s hereditary or non-hereditary, because diagnosis is so poor, they often are really sick. Their ferritin is over a 1,000, sometimes over 2,000 or 3,000. And then they go to the hematologist, which unfortunately it takes forever to get in. And usually, they’ll have blood removed if possible and they’ll try to remove blood as frequently as possible. So if you go to the hematologist, they can remove blood more frequently. Whereas if you go to the blood donation center as just a donator, you can only remove blood like every six weeks unless they sign a form. Your doctor signs a form that says you can go more often in a two-week interval or whatever.

                                But regardless of how you’re getting that blood removed, at some point in time, if your iron’s really, really high, you will be limited by getting the lower iron by not being able to remove more blood. Because at some point in time your iron’s still going to be high, but you’re going to become anemic because you just removed so many red blood cells and hemoglobin, but you still have so much iron stored in your body. And then you have to wait, well, this is without step 2, 3, 4, 5, you have to wait for your hemoglobin and red blood cells to come back up before you can remove blood again. And so because blood donation is like the primary tool used by hematology and they’re not using these supplements, they talk about don’t take vitamin C, don’t take iron, things like that, but they don’t really dig into using the supplements, which I think is a huge disadvantage to their patient population. And I hope that my book helps to change that.  So anyways, blood donation is a very useful way. I think it always needs to be used in tandem with diet, supplements, lifestyle. If you go to the hematologist, they’re probably just going to be using the blood donation. In some rare cases, they might use a pharmaceutical chelation, which they have a lot of side effects. And the research that I put in my book shows that the nutrients actually work better without the side effects and have positive health promoting side effects, health promoting benefits. So-

Dr. Weitz:            Let’s go through some of those nutrients.

Dr. Sutton:          Okay. So the nutrients are, the most common one that I use is curcumin because it’s anti-inflammatory. I’m a chiropractor like you. A lot of people, my hemochromatosis patients, have a lot of joint pain from high iron and other reasons too, but part of it is the inflammation from the iron. And so the nice thing about the curcumin is that it can lower iron, but it also decreases inflammation and can help with some joint pain related to that. And then the patient feels better. That gives them… Because some of these people-

Dr. Weitz:            Curcumin is an amazing supplement. If you look at the anti-cancer properties, the brain protective, heart protective, curcumin is an amazing supplement. So it’s definitely one of my favorites.

Dr. Sutton:          It is one of my favorites. As a low iron person, I wish somebody would invent a curcumin that lowered inflammation without lowering iron. But I don’t think that exists. Because I have Crohn’s and even I’ve had a gastroenterologist say, “Curcumin is great for that.” In fact, I remember the conversation vividly, it was years ago before I wrote the book, he was like, “Curcumin is great for inflammatory bowel disease. For some reason it lowers iron, but we don’t know why.” I’m like, “Well, actually we don’t know why it binds iron, but that’s okay. It’s still good information.” So yeah, curcumin is a great one.

Dr. Weitz:            And one of the clinical pearls, actually, I’m going to mention two clinical pearls that you just happen to mention that I’m not sure everybody’s aware of that is really interesting is turmeric can cause kidney damage, but curcumin does not. So the patients who come in and say, “Well, I’m taking turmeric,” I usually inform them that turmeric is very poorly absorbed and even curcumin is not absorbed so we have to use a specialized form of curcumin. But that’s interesting that turmeric can have some possible other side effects, especially if you’re trying to use it at a high therapeutic dosage. And number two, you mentioned that curcumin interacts with tamoxifen and can increase its efficacy in the treatment of breast cancer and can even prevent, tamoxifen, cancers from growing and reduce the toxicity of tamoxifen. And tamoxifen is an estrogen-blocking drug often used as part of a protocol for patients being treated for breast cancer. So extra benefit of curcumin.

Dr. Sutton:          Yes. Yeah, that’s great. I forgot about those little things. Good job.

Dr. Weitz:            And to reduce iron, we have to use a relatively high dosage of curcumin, correct?

Dr. Sutton:          Yeah. I mean, I feel like the most common dosage I see for that type of an equation is a 3 gram a day, which most the curcumin that I use is 500 milligrams per pill, which is a-

Dr. Weitz:            Which one?

Dr. Sutton:          I use… So it’s Epigenozyme, which full disclosure is my brand, but that’s Epigenozyme Inflam-Redux Turmero. And I use six pills a day of that for if it’s like an acute situation. Whether it’s acute pain. I really like to have an iron panel on anybody I’m putting curcumin on because I don’t want to cause them to be anemic. If they’re anemic, I’m probably not going to give them curcumin even if they’re in pain and it’s inflammatory pain because I don’t want to create a problem. Let’s figure out how to fix this without causing another problem. But for a high iron person, 3 grams a day, which is about six pills a day. Now one limiting factor is in some people it can cause some loose stools. And so sometimes you just have to dose up to your bowel tolerance. Spreading it out throughout the day helps and taking it with meals can help as well.

Dr. Weitz:            Do you take it after the meal, with the meal, before the meal?

Dr. Sutton:          I would say with, with the meal, because the meal is where the iron is, and so it’s going to have the biggest effect there. It’s also less likely to create gastric issues, if so.

Dr. Weitz:            Okay.

Dr. Sutton:          So taking it with a meal is a good idea. And then I just wanted to add, the reason that turmeric causes kidney issues in some people is because it’s high in oxalates, whereas the curcumin is not high in oxalates. When you’re doing something therapeutically, it’s really important to make sure that you are consistent and you’re able to measure what you’re doing to know if it is or is not working. And so while if a patient just wants to do turmeric, it’s like, “I don’t know how much turmeric you’re taking on a daily basis in your diet.” I’m not saying don’t eat turmeric. There’s a lot of good things about turmeric. I just don’t think if you’re going to be using curcumin therapeutically to turmeric as a good option, just for the same reasons you mentioned, so yeah.

Dr. Weitz:            And the next nutrient you mentioned in your book is silymarin from milk thistle.

Dr. Sutton:          Yeah, silymarin’s great too. So before I say anything about silymarin, I think it’s worth mentioning that there is some research that shows that silymarin, curcumin, some alpha-lipoic acid, some of these iron binders, they have been shown to decrease stored iron in the brain, the liver, the spleen. I think that’s really valuable information. I don’t really have this problem with my hemochromatosis patients, but I have seen on a lot of the Facebook groups, like people that say, “Oh, I have this joint pain and my iron levels are normal.” And it’s like, “Well, either you’re not fixing the underlying cause of the joint pain. It could be something else. It could be rheumatoid arthritis. I don’t know. You’re not my patient. I don’t know what’s going on with you.” But really adding that curcumin helps with a lot of unresolved joint pain in these hemochromatosis patients because I think it’s getting the iron out of the joint.

Dr. Weitz:            That’s fascinating. And we also know that amyloid plaque, one of the reasons why it’s laid down in the brain, which is related to Alzheimer’s disease, is to protect the brain, the neurons, against heavy metals. And too much iron can be a heavy metal that can damage the brain, so…

Dr. Sutton:          Mm-hmm. Yeah. Yeah. So that’s worth knowing. And then silymarin, it also binds to iron. Well, curcumin is very good for the liver. silymarin is particularly one of its better attributes if an herb can have an attribute, is that it’s really good for the liver. So silymarin is the extract from milk thistle. So because hemochromatosis is quite ruthless and unrelentless to the liver, it is very nice to have something that will both lower iron and protect your liver. It is in the ragweed family, so if you’re super allergic to ragweed, then it might not be your best option.

Dr. Weitz:            You also point out, another clinical pearl, that silymarin, this is for men, can increase the number of sperm, and we know sperm counts are going down. And it can reduce BPH, benign prostatic hypertrophy. I didn’t know that. So that’s another…

Dr. Sutton:          Yeah. Yeah, that’s good. I forgot a lot about these clinical pearls honestly. There’s a lot in this-

Dr. Weitz:            There’s a lot of them.

Dr. Sutton:          There is a lot in this book.

Dr. Weitz:            You threw in there and I was like, “Whoa!” 

Dr. Sutton:          I know. I need to go back and read it, but honestly I never want to read it. I’m so tired of looking at it, so thank you for helping me remember.  Okay. And then the next one is quercetin. I do use a lot of quercetin. Quercetin does not bind to iron, but rather it increases hepcidin, which lowers iron absorption. The problem with people that have hereditary hemochromatosis is that they do not have enough hepcidin. They’re naturally low in hepcidin. That’s what the genetic change does to their body. That enzyme that makes hepcidin, it just makes less hepcidin. So if you take quercetin, it can boost the hepcidin production and decrease iron absorption. And then quercetin just has a lot of other wonderful antioxidant health-promoting effects as well. Lowers histamines, so it can help with allergies. Quercetin-

Dr. Weitz:            You mentioned also in your book that one of the side effects of high iron can be mast cell activation and high histamine.

Dr. Sutton:          Right. Yeah. Yeah. So that’s a good one. And then of course with the pandemic, quercetin kind of got its heyday with it being a… It can help drive zinc into the cell.

Dr. Weitz:            Exactly.

Dr. Sutton:          And then there’s berberine. I don’t use as much berberine because we will talk about what berberine does. It also increases hepcidin. And there’s a lot of good research that shows berberine’s great for the liver and lowering cholesterol and the heart. However, I had one patient that she took berberine and her liver enzymes went high. And it kind of made me uncomfortable using the… I had to rethink berberine because if you have a hemochromatosis patient, their liver enzymes might already be high. Maybe you need to hold off on the berberine because if somebody has high liver enzymes already because hemochromatosis and you give them berberine, you might not know if their liver enzymes are going high because of the hemochromatosis or the berberine. So in my opinion, and this is a newer opinion, is if you have hemochromatosis and you want to lower iron, wait until your liver enzymes are in a normal range and you’re in a more managed range before you consider adding the berberine.

Dr. Weitz:            Just my clinical experience, whatever that’s worth, I use a lot of berberine. I love berberine, I use it for blood sugar lowering. It’s one of the few things that’s been able to reverse atherosclerotic plaque. Berberine is… I’ve not seen any patients who had an increase in the liver enzymes from taking berberine. Berberine is like a natural form of metformin.

Dr. Sutton:          Yeah. No, I love berberine. I’m not willing to take it off the table, but I feel like I needed to tell that story so that maybe berberine is not used at the very beginning. Maybe you wait until the liver enzymes are normal because then if it does cause them to go high… And I think this lady just had something else going on that was like-

Dr. Weitz:            Well, a lot of times patients are doing multiple things, you know?

Dr. Sutton:          Yeah, I mean she was pretty certain it was berberine and I couldn’t say otherwise. But there is some research that shows that berberine can increase liver enzymes, but then there’s other research that shows that it lowers it. So berberine is a great thing.

Dr. Weitz:            [inaudible 00:48:06]. Another clinical pearl in your book you mentioned berberine is useful for autoimmune patients because it suppresses pro-inflammatory responses to Th1 and Th17 and increases T-regulatory cells.

Dr. Sutton:          Oh, that’s great. Can you just read that chapter to me?

Dr. Weitz:            I always listen to my own podcast and my wife goes, “Why are you listening to yourself? “It’s because sometimes I find out stuff that we forgot to edit, and so it’s important.

Dr. Sutton:          Uh-huh. Yeah. It is good. I cannot listen to myself. And apparently I cannot read my own writing.  Okay. And then the next one is glutathione. Glutathione does not lower iron, however, it’s essential for everybody, particularly hemochromatosis patients because it protects the whole body, liver, brain, heart, spleen, pancreas, joints, everything from high iron and iron-induced damage. And it protects from ferroptosis, which is where high iron causes damage to the cells and then the cells die. So you know if you have high iron, you’re going to be low in glutathione. And then the best thing to do is to just supplement with extra glutathione. And I like the liposomal glutathione. That is liquid. So if you’re a pill person, the S-Acetyl L-Glutathione is a good option as well. What you don’t want to do is you don’t want to do N-acetylcysteine while your iron levels are high because that can increase iron absorption.

Dr. Weitz:            You mentioned a really high dosage of glutathione. I know the form of liposomal glutathione that I like, which is the Quicksilver one comes in 100 milligrams strength, and you mentioned taking 1,000 milligrams. So with that one it might be hard to get it up to that level.

Dr. Sutton:          10 pumps a day.

Dr. Weitz:            Oh, okay.

Dr. Sutton:          It’s not that hard.

Dr. Weitz:            Okay.

Dr. Sutton:          It might be expensive, but it’s not that hard.

Dr. Weitz:            Yeah.

Dr. Sutton:          Yeah. Yeah.

Dr. Weitz:            Good.

Dr. Sutton:          And in acute situations is where you need the higher dosage. As somebody gets into a more managed range, you can adjust and lower or remove as you desire. But if somebody has a high ferritin, their iron ranges are out of range, then that’s an acute situation and you are definitely protecting yourself from damage by taking extra glutathione.

Dr. Weitz:            That’s great. You mentioned CoQ10 and resveratrol as well.

Dr. Sutton:          Yeah, so CoQ10 does not lower iron. However, it’s analogous to glutathione and that it helps to protect from iron induced damage. People that have high iron tend to be low in CoQ10. And low CoQ10 not only make you feel bad, but it is really bad for your heart and your health. So that’s an important way to protect.

Dr. Weitz:            And there’s two forms of CoQ10 on the market, ubiquinone and the ubiquinol. Ubiquinol is much more expensive and is marketed as more highly absorbed. You mentioned that, another clinical pearl, is that the ubiquinol is actually better absorbed.

Dr. Sutton:          Yeah. In my opinion, and I think if you really ask some of these supplement companies and they’ll give you an honest answer, they’ll agree with me. Ubiquinol is a scam. It’s a scam. It’s a way to get people to pay more for the “activated form.” And the reason it’s a scam is because it’s, one, it’s not shelf stable. So they might put ubiquinol in that supplement, but it has converted to ubiquinone usually by the time you take it, okay? And if it is ubiquinol, then it will convert to ubiquinone in your digestive system because ubiquinol is not absorbed well in the digestive system. Ubiquinone, the cheaper stuff, is well absorbed. And once you absorb it, it will get converted into ubiquinol.

Dr. Weitz:            Cool. And you mentioned resveratrol. You mentioned in your book that it suppresses iron overload, induced heart fibrosis and improves cardiac function. I didn’t know that about resveratrol.

Dr. Sutton:          Yeah. Resveratrol for the heart and people with any heart issue. It’s also really good for the brain. But because if you have high iron, you’re more likely to have fibrotic heart, heart disease, heart failure, heart issues, resveratrol is very protective against that. It does not lower the iron, but it’s very protective against the iron-induced damage in the heart, which is valuable.

Dr. Weitz:            Cool. Great. Maybe you can give us one example of a patient that you were managing with higher iron and then we can wrap.

Dr. Sutton:          Okay. Well, yesterday I talked to a lady who I’ve had maybe four visits with her. She found me. She did, I think the Iron Curse workshop because I think she kind of knew she had some high iron issues that the doctors were not looking at. I don’t know how she found me or the workshop, but she took the workshop and she started using some of that information to make some changes. And what she did was really valuable is she got the genetic testing and the labs. She did the best she could. And then she made a couple appointments with me.

                                So she has one C282Y gene. The first appointment with her, she was still pretty high in ferritin. I might be on the numbers here, but I think her ferritin was in the 500s, but had come down from the 700s with the work that she had done, and she basically diagnosed herself. She wanted to talk to me for confirmation. Yes, she had a high iron saturation, like 55, and then she had a high ferritin, but nobody else cared. She figured out herself. And then she came to me and we just talked about it and she wanted my confirmation. I’m like, “Yeah, you do have a problem. You really do need a hematologist.” And she is in the process of trying to get one, but their finances are pretty rough right now for multiple reasons, and I don’t know if it’s going to happen.

                                So anyways, so what we did was she had kind of started a couple supplements, but you know what I’m talking about. People come in and they hear about something, and then they start it and then they hear about something else and they start it. And they’re just, by the time they come in, they have 30 different things and they have this bag, and it’s like, “Well, these are good in theory, but this isn’t what you need. If you just want to wing it, and a lot of these things, they’re kind of working against each other and the quality might not be there.” And so what we did was we just-

Dr. Weitz:            [inaudible 00:56:00] just combination products that have things that are good and things that aren’t.

Dr. Sutton:          Yeah, exactly. And so what we did was we tailored down her supplement list to more specifically her needs, which her biggest problem was not just the high iron, but she has an Alzheimer’s gene too and was dealing with a lot of brain fog. And so what we did, what she started taking was she started taking… I just saw her yesterday, so this is all fresh in my head, but I’m not looking at it so I might be wrong a little bit. She started taking a higher dose of curcumin. So I think she was taking two. We tried to put her on six, but she could only tolerate four. And then she couldn’t do the silymarin and she did not tolerate the resveratrol at all. It caused digestive issues, so we couldn’t do that. We put her on the quercetin and she got on a good DHA fish oil for her brain. She got on something called cognitive complete, which has a lot of vinpocetine and huperzine and ginkgo biloba. And that is really what fixed her brain fog, because that got more blood to her brain.

                                And then we did follow up labs, and she had come down to 150 on her ferritin using just the supplements. No, she donated blood once. She donated blood once and she took those supplements. And then she couldn’t donate blood again after that because her red blood cells were not in a range. That was really a good idea. And then she stayed on the supplements and on the lower iron diet as well. And the next time she did the labs, I think her ferritin was like 112, so it continued to come down. And we’re going to get another one. I just ordered more labs on her yesterday, so we’re going to get another one here soon. But-

Dr. Weitz:            Your goal for her ferritin, you want to see it where?

Dr. Sutton:          Well, she’s got one of those hemachromatosis genes and she’s postmenopausal. So ideally I’d like it to be probably below 60 so that she’s got a buffer to protect her from it going high. But 112 is exponentially better than 700.

Dr. Weitz:            Of course.

Dr. Sutton:          And it was going in the wrong direction. What we talked about yesterday, I guess this is why I wanted to tell this story now I’m realizing, is she was so appreciative because yesterday we talked about her granddaughter who is six years old and we were looking at her granddaughter’s genes in labs. Her granddaughter has a celiac gene, has a hemochromatosis gene, is having a lot of health problems. Her iron levels were actually normal, but she was low on vitamin D and low on B vitamins and had a high inflammatory CRP. So we talked about we really need to either get more labs to see if this girl’s a celiac, gluten-sensitive child or put her on a diet. She couldn’t afford the labs, and so they’re going to put her on the gluten-free diet. But here’s the reason that this is so important, is she was like, “I think God sent me to you because I needed to get better to take care of my granddaughter because her mother is an alcoholic that has a 40% chance of surviving the next year.”

Dr. Weitz:            Wow.

Dr. Sutton:          And now she feels good now. Her granddaughter hopefully will start feeling better soon, but she now feels good. She has energy, she’s clear-headed. She’s going to hopefully live a longer, healthier life and be able to take care of her granddaughter who desperately needs her. And so I guess that sometimes it’s not like that one person we’re helping, but the circle around them that is so meaningful.

Dr. Weitz:            Yeah, that’s great. That’s a great story.

Dr. Sutton:          Yeah. Yeah.

Dr. Weitz:            So tell listeners how they can find out about getting you books. You have some courses that are available.

Dr. Sutton:          Yeah. So the Iron Curse workshop is at ironcurse.com. And then if you go to christysutton.com, pretty much everything I have is there. And I have that Iron Curse workshop, which is me verbally going through everything as far as hemochromatosis, anemias, everything that’s in the book, and then just more kind of discussion.  And then I have other workshops. I have one on brain health, Alzheimer’s, Parkinson’s, cognitive decline. I have one on celiac, gut issues, one on age-related macular degeneration. I have one coming up on heart health. And then I have another one, oh, the MTHFR one, which is just methylation. And then I think I have another one, but I can’t remember. Anyways, they’re all at that website.

                                And then my books, I have my first book, the Genetic Testing: Defining Your Past to Personalized Health Plan, which is a decent book and a lot of people love it and my greatest critic, and I will call it decent. But if you’re looking into the hemochromatosis part, don’t go there. Go to The Iron Curse. The Iron Curse is, I would say, a really good resource for iron related issues. The first book has a lot of different genes. I wrote that a long time ago, and I think it’s an important piece of information. But if you’re interested in the iron piece, don’t go there. Go here to The Iron Curse book.

Dr. Weitz:            Awesome. Thank you, Christy.

Dr. Sutton:          Thank you.


Dr. Weitz:            Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a 5-star ratings and review.  If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. So many areas I specialize in include helping patients with specific health issues like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way. Please call my Santa Monica White Sports Chiropractic and nutrition office at 310-395-3111, and we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

 

Dr. Allison Siebecker discusses Controversies in SIBO Testing and Treatment with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

1:28  Testing for SIBO.  Dr. Siebecker still prefers the SIBO breath test that measures hydrogen and methane that has been around for years and she prefers the version where they do it for three hours.  She also likes the Gemelli Labs Trio-Smart test that measure hydrogen, methane, and also hydrogen sulfide gases, which is the newer SIBO breath test.  Dr. Siebecker has a hydrogen sulfide SIBO study group and the consensus in the group is that Trio-Smart under-reports methane.  On the other hand, the studies used to validate the Trio-Smart test were really good.  Using the older SIBO breath test, if there is a flat line for hydrogen, this is often used to indicate hydrogen sulfide SIBO. Dr. Josh Goldberg and Dr. Siebecker and others have found that if patient did both the older SIBO test and the Trio-Smart, there was not a good correlation between the flat line and a positive result for hydrogen sulfide.  On the other hand, Dr. Siebecker pointed out that when patients with a flat line get tested with treatments for hydrogen sulfide, they often improve and feel better.   

7:37  Three hour SIBO breath test.  While it is more common to do the SIBO breath test for two hours, Dr. Siebecker prefers that the test be done for a three hour period of time.  For one thing, while excess hydrogen production is known to occur only in the small intestine, the organisms that cause excess methane and hydrogen sulfide are known to overgrow in the large intestine as well as in the small intestine.  Therefore, doing the SIBO test for 180 minutes instead of only 120 minutes can help, with the assumption that after 120 minutes the lactulose is in the large intestine.

11:50  Fructose as the substrate.  The use of fructose and glucose as well as lactulose as the substrate for the SIBO breath test. While the SIBO breath test is most commonly done with lactulose, some doctors, such as Dr. Jason Hawrelak from Australia, often has patients perform the test with lactulose, glucose, and also fructose. In fact, Dr. Hawrelak has found that fructose is actually more accurate than lactulose for diagnosing SIBO.  If you have a patient who tests negative with lactulose, you might consider having them repeat the test with fructose.

17:57  The Food Marble.  The FoodMarble is a portable SIBO breath testing device that the patient can buy and use at home over and over as needed and this device it threatens to upend the SIBO testing industry.  It can help you to figure out your dietary triggers.  Once you buy one for about the cost of a breath test, it allows you to be able to retest regularly, which otherwise can cost a lot.  And the validation studies on its accuracy seem to be pretty good.

 



Dr. Allison Siebecker is a Naturopathic Doctor and Acupuncturist specializes in the treatment of Small Intestinal Bacterial Overgrowth and she teaches advanced gastroenterology at the National University of Natural Medicine. She has the most incredible resource of research articles and information about SIBO, siboinfo.com

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz:                            Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates, and to learn more, check out my website, drweitz.com. Thanks for joining me, and let’s jump into the podcast. Hello, Rational Wellness Podcasters. Today, we’ll be speaking with Dr. Allison Siebecker, one of my favorite people, about controversies in testing and treatment for small intestinal bacterial overgrowth.   Dr. Allison Siebecker is the Queen of SIBO. She’s a naturopathic doctor and acupuncturist specializing in the treatment of small intestinal bacterial overgrowth. She teaches advanced gastroenterology at the National University of Natural Medicine. She has the most incredible resource of research articles and information about SIBO at her website, siboinfo.com. Dr. Siebecker has been participating in the SIBO SOS program, which is another incredible resource of courses and information about SIBO. Allison, thank you so much for joining us.

Dr. Siebecker:                    Thank you so much for having me.

Dr. Weitz:                           So let’s start off with testing for SIBO. So which SIBO tests do you currently recommend?

Dr. Siebecker:                    Right, because we have some new additions in here.

Dr. Weitz:                           Yes.

Dr. Siebecker:                    Well, I still like the standard test that most of us have been using, which is a test for hydrogen and methane and uses lactulose. I like it three hour, and I like it when it has… The most samples that it can come with typically on the market is 10, meaning 10 tubes or bags or collection items. So that’s the standard for a very long time, and I still really, really like that. But we do have some newbies. Gemelli Labs has Trio-Smart. That’s been out about three years now, I think, but it still feels new, right? For a lot of us.

Dr. Weitz:                           It’s only available in the United States I think at this point, right?

Dr. Siebecker:                    I think so. Yeah. That one tests for hydrogen sulfide. We were all really excited, waiting for that. I like that test too because it tests for hydrogen sulfide. Then I feel a little bit bad to share this just with the public but I will is that I have a hydrogen sulfide study group that we assembled a bunch of practitioners to basically study when the Trio-Smart came out and help each other with what we were all seeing. From that group, many of the doctors in there, they shared that and basically they saw when they would compare the test against the standard hydrogen methane test because they would run too often on one person that the methane sometimes was lower on the Trio-Smart than on the traditional test.  So some of the docs there, they just felt that it may be under-reported methane, the Trio-Smart. Now when the studies are done, studies were done to validate Trio-Smart against the standard machinery. The studies were great, so it doesn’t line up. This is more of like a clinical happenstance. Studies are great. So just passing that along. Because of that, it’s really hard to explain why I haven’t switched fully over to Trio-Smart, because I’m always very concerned about missing anybody with SIBO. I want to be sure that I find it when it’s really there. By SIBO, I mean the methane type of SIBO as well.

Dr. Weitz:                           How valid do you think the flat line is as a way to diagnose hydrogen sulfide?

Dr. Siebecker:                    Well, this is really interesting. So for years, that’s what we use. We still use it. I found it very effective in that when you treat people with treatments for hydrogen sulfide and they have a flat line, they respond. They get better. You can often see the next, the retest perform like you’ve seen, they’ve gotten better. Meaning it won’t be a flat line anymore. Also, one of the directors of one of the breath testing labs, for years, I had been gathering symptoms that my patients had that they told me they had when they had a flat line. I was able to come up with this little group of symptoms that to me indicated hydrogen sulfide. I shared that with anyone who wanted to know in all my lectures and things.  So the director of this lab started using that and he got back to me and said he found an excellent correlation with this and that people would really respond to treatment. So here’s this clinical data that seems good. But then my friend who’s does a lot of research, Dr. Josh Goldenberg, he and I and several others, he really led the effort, did a survey. In that survey, so this is low quality evidence, but here it is. We actually found that when people compared the flat line with the Trio-Smart. So do people with a flat line actually have hydrogen sulfide gas? There was a very poor relation. What is a flat line then if it’s not actually hydrogen sulfide? I don’t know. Is this definitive? No, because this is just a survey. It’s not good quality evidence.  But it made us think, “Huh, maybe the flatline isn’t what we always thought it was,” except I don’t care. Because when we treat it like it’s hydrogen sulfide, people get better. But that is an interesting thing that we don’t often see. I’m sure other people will have their own evidence, but someone with a flat line testing positive for hydrogen sulfide on our Trio-Smart. I don’t know why.

Dr. Weitz:                           Have you found that the Trio-Smart also has a relatively small number of positive hydrogen sulfides?

Dr. Siebecker:                    Yeah, I mean that makes sense. Hydrogen sulfide is going to be the least common type of SIBO, the least common gas. Never expected.

Dr. Weitz:                           I’ve heard 10 to 15%.

Dr. Siebecker:                    Yeah, I think so. Maybe less. I mean, it’d be interesting to hear what Dr. Pimentel says, who’s probably got the most experience at saying what the percent is, but that makes sense to me. Pretty low, right? So yes, but the thing is it can be this tricky thing. I think where we want to bring in for sure testing and make sure we’re not missing it is in cases that are challenging. If everything’s going great and you’re treating and there’s no issue, you don’t have to think about it.  But what if somebody still has symptoms and you don’t know why and their test looks negative or things like that or the treatments you’re giving for hydrogen or methane aren’t quite working? Geez, maybe they have some hydrogen sulfide there you don’t know about because clearly there can be hydrogen sulfide without there being a flat line. Then you would need to shift your treatments.

Dr. Weitz:                           Now explain why you feel it’s important to do three hours. Because if on average after 100 minutes or certainly 120 minutes, you’re now in the colon. How are we diagnosing a small bowel issue with a three-hour test?

Dr. Siebecker:                    Because we have these three types of SIBO, hydrogen, methane, and hydrogen sulfide. Methane even now is not really considered a type of SIBO, though I still consider it that way because that’s so long I’ve thought of it that way. So it’s intestinal methanogen overgrowth. Well, it’s only the hydrogen that is small intestine only. So both methane and hydrogen sulfide, those organisms overgrow in the large intestine as well. On our breath test interpretation, we use the whole three hours for the interpretation. So this is why it’s so important. I mean, I have example after example where we could miss somebody’s methane or hydrogen sulfide if we only had 90 minutes or two hours.

Dr. Weitz:                            So if you see a dramatic rise after 120 minutes, you would still consider that positive in either methane or hydrogen.

Dr. Siebecker:                    Not hydrogen, methane or hydrogen sulfide. That’s the thing. That’s the thing. It’s only hydrogen that we’re using the first two hours. But for methane and hydrogen sulfide, we need that third hour, because it’s not just yes or no because the level of the gas influences our treatment choices. Because amongst our different choices, we may choose a treatment that is better at reducing more gas more quickly. Also, it informs our prognosis because we know most people will need multiple rounds. We know on average how much each treatment lowers gas on average.  So we can calculate how many rounds might be needed by seeing how high the gas goes. So we need that information. The other thing is why wouldn’t you just get all the information that would help you if the person’s going through the test? So it really irritates me when manufacturers only offer two hours or less. It’s like you’re shorting us out here. I mean, the person is going through the effort. They did the prep diet, they’re doing this whole thing. What is one more hour? Let’s get all the information we need.

Dr. Weitz:                            Now, isn’t another argument though that the issue about SIBO is that if this bacterial overgrowth occurs in the small intestine and gas is produced, you’re going to have all these symptoms? But if that same gas is produced in the colon, you’re not necessarily going to get those same symptoms because the colon is this very extensible tube and it easily expands. There’s always bacteria producing gases in there, and that doesn’t typically create symptoms.

Dr. Siebecker:                    I don’t think that’s true. I don’t know. I haven’t read studies to prove this one way or the other.

Dr. Weitz:                           But isn’t fermentation very common in colon and isn’t that good, actually healthy?

Dr. Siebecker:                    Yes, at a certain amount. So I think it’s about the amount. It’s about how rapidly the gas is created and how much. Actually, this is the whole basis of the FODMAP diet is just that rapid and excessive gas creation in the larger intestine leads to a lot of symptoms. It is completely my understanding that you would not escape symptoms if there was a lot of gas in the large intestine.

Dr. Weitz:                           Okay. I thought the purpose of the low-FODMAP diet was not to feed the bacteria in the small.

Dr. Siebecker:                    Yeah, they did have SIBO or the small intestine in mind in some of their early papers but barely. Their main target was the large intestine actually, believe it or not. Also, inflammatory bowel disease. Now it’s changed since then. They’ve morphed, but that was the original intention. What I love about that diet is they’re like, “We don’t know what’s causing it. We’re not even going to try and think about it. We’re just trying to help symptoms.”

Dr. Weitz:                            Some doctors, for example, Dr. Hawrelak likes to use different substrates for the SIBO prep test. He told me that he regularly will have his patients do a test with lactulose, a test with glucose, and a test with fructose.

Dr. Siebecker:                    Yeah, I love this. So this is great. This all came out of a conversation he and I had at a conference when we were lecturing. Because long ago, he was a fan of glucose, and I was never a fan of glucose as a substrate because I knew it absorbed pretty quickly, pretty high up in the small intestine. So it couldn’t test the whole rest of the small or the large intestine. We were just talking about how important that is. So I said to him, I said, “Could you give me more information about the comparison between glucose and lactulose? Tell me what you think.” Well, he’s a researcher. So he’s fabulous. He went in his office and he did this in-office study over years. He didn’t publish it, but then as soon as it was ready, we came and I featured him giving out a class on this.  He’s been telling everybody. He came out with the most fascinating information. He found that, well, glucose was the worst at finding SIBO in somebody who had it. So he ran, like you said, each one of these substrate tests on the same person. Lactulose was second best. Fructose was the best and best of all was lactulose and fructose. He ran these on different days. So I brought up the statistics so I could tell you from a study. So glucose was 67% of a diagnostic rate, lactulose, 73%, and fructose, 85%. When we did the fructose and the lactulose together on separate days, it was 96.5%. So this just blew me away and has changed my mind about a lot of things. So what I’ve been doing is recommending to practitioners who are having trouble getting a lactulose test.

                                                There are companies where you can get the lactulose test, but not everybody knows that or wants to do it. So they can order fructose. This made me feel comfortable, recommending fructose as a substrate. It’s interesting, because in my early testing, I did test people with different substrates. This is like 14 years ago or whatever. I didn’t do as many as Dr. Hawrelak. He did 130. I have it written down here, 130. I didn’t do that many. So you need a lot to figure things out, but I often found that people were not positive on a fructose test who were positive on lactulose. So this really surprised me, and that’s the value of doing a bunch of these. Now I have something else to tell you. Dr. Nirala Jacobi, another one of our colleagues, she has a lab in Australia also.  She is now checking this out for herself, and she is running a lot of these lactulose and fructose. She’s only in preliminary data, so it is too early to speak. Please keep that in mind, but she isn’t finding fructose to be better than lactulose. She didn’t tell me if it was the same or worse, just not better at this point. She’ll come out her with her findings, but I still feel confident based on the data from Dr. Hawrelak. So I think it’s a wonderful thing to think about. Something else that he discussed is that he found people who would be negative on lactulose but positive on fructose. I mean, obviously, that’s the difference between that 73% and 85%. So it’s something to keep in mind if you really feel like somebody, you really suspect SIBO and you test them and they’re negative.  You could run a fructose just to see. That’s also the place where you might want to test with the trio if you weren’t to see if there was hydrogen sulfide, if something’s in your mind going, “But I really feel like they have it.” So I’m generally in favor of it. I haven’t switched over to it.

Dr. Weitz:                           Interesting. So one of the issues for some patients and some practitioners is that… I don’t know if this is across the whole country, but lactulose is considered a prescription drug. I know in California-

Dr. Siebecker:                    It’s so irritating. Oh, no, the whole country.

Dr. Weitz:                           The whole country, okay.

Dr. Siebecker:                    It’s a mistake that it’s on there. I’ve talked to so many people about this, but the problem is it would cost a lot of money to get it off the formulary. So it’s going to stay there and it’s a terrible mistake. It shouldn’t be. So then non-prescribing practitioners technically can’t order it, but there are labs you can order it from. Basically, I can just speak about labs because there’s no CE. So Genova offers it and that you can get that also through Rupa Labs, True Health Labs, direct labs.  So they’re the main way. The other thing is that a lot of times, a patient’s primary care, they can give them a prescription for lactulose as a laxative. It’s often used in veterinary medicine. So you could get it and then you could buy a no substrate or a glucose test kit and then substitute it. But here’s now the fructose as a potential option.

Dr. Weitz:                           Is it the same amount as lactulose?

Dr. Siebecker:                    No, it’s 25 grams. Let me just make positively sure that I got that right. I have a little note. Yeah, 25 grams for fructose, 10 grams for lactulose

Dr. Weitz:                           Mixed in eight ounces of water?

Dr. Siebecker:                    Mixed in eight ounces of water. It has to be diluted. Same with lactulose. Isn’t that fascinating?

Dr. Weitz:                           That is fascinating.

Dr. Siebecker:                    Did you have him on to speak about it?

Dr. Weitz:                           Yeah, we did speak about it.

Dr. Siebecker:                    Yeah, fascinating to me.

Dr. Weitz:                           He continues to use all three.

Dr. Siebecker:                    He says sometimes he uses just two, unless he’s changed. Last I heard he had dropped glucose, but he might. Who knows?  He might’ve brought it back because he’s like, “That’s out.”

Dr. Weitz:                           So what do you think about the new SIBO testing device, the FoodMarble?  Is this threatening to disrupt the whole SIBO testing industry?

Dr. Siebecker:                    Right. I forgot. This is the other newbie on the block here, so I have so many thoughts.

Dr. Weitz:                           For those listening, you might not be aware. There’s a home SIBO testing device. It’s known as the FoodMarble, and you can use it over and over again at home. You can test yourself in whatever way you want exactly. You just breathe into that. It measures hydrogen and methane. I think they’re working on a version that’s going to include hydrogen sulfide, and you could duplicate a SIBO breath test. You could do lactulose or fructose and then do it every 15 or 20 minutes, or you can just see how you react to different foods.

Dr. Siebecker:                    Exactly. Yeah. I think that the original intention was just to help you figure out your dietary triggers really. People love it for that. They just test after eating various types of meals and they see where their gas levels are. The gas report comes as a fermentation score, which goes as high as 10. They’ve now broken out the different hydrogen or methane, and they let you know. So it’s not parts per million like it is in a breath test. It’s just to give you a sense of what’s going on, but it works with an app and it’s very user-friendly. On the app, the challenge function is how you do a formal breath test and then you choose whatever substrate you’re going to use. Like you said, you could just buy glucose or fructose or if you can get a prescription for lactose.

                                                So I think it’s amazing because it’s inexpensive and I love that. So because they claim that this device is able to do accurately many, many, many breath tests, I think 40 or more. I think it’s more than that. So that’s for the price of one. It costs about the same as doing a breath test, and then you can run multiple, multiple tests. That’s just incredible because the budgetary concerns are sometimes the biggest impediment in the whole treatment process with SIBO. I mean the treatments can cost a lot too, but I’m a physician who likes to retest a lot. Otherwise, I just feel blinded. You can’t really judge my symptoms very well. What the heck is actually going on with the overgrowth levels? Because they don’t correlate perfectly.

                                                So this can solve the budgetary issues, the retesting issues. So that’s incredible. It’s also so user-friendly. Anyone who’s ever tried it or used it, they love it. I’ve tried it. I think it’s great. It’s so easy to use. Now the issue is what about the validity? This is what everybody wants to know. Just like Trio-Smart, they have done studies that are great and show excellent validation against our standard testing machinery. A colleague of mine, the one who I did that hydrogen sulfide study with, he said he likes the studies. He feels good about the studies. Everyone has to decide for themselves, but I like that a colleague who was a researcher felt good about the study. So that’s good. So that’s good. Now, what about in real life, right?

                                                So in practice, sometimes we see some odd things like an occasional really high level of gas that just blips up. That’s hard to make sense of. Is it correct? It has an opportunity to potentially be more sensitive and more accurate because it’s analyzing the breath instantly, instead of being shipped off for a week in transit and then being analyzed. Because of that, the FoodMarble has a trend I think to have slightly higher gas levels, probably because it’s being analyzed immediately, although there could be other reasons for that. But a number of us have done side-by-side testing. Whenever we do that, by the way, Dr. Pimentel has recommended giving five minutes apart when you’re breathing into two different devices.

                                                The technicians and the scientists at FoodMarble say even two minutes might be enough, just letting you know for anyone who wants to do this, because you need the gases to be able to equilibrate again. You don’t want to have them completely blown off from one test to the next. So anyway, when we’ve done comparison side-by-sides, people are finding different things. I find in the ones I’ve done only I think one or two of them lined up correctly perfectly. Then I’ve seen it all different ways where hydrogen or methane was higher or lower in my side-by-side tests. I haven’t really quite decided what that means and what I think about it. I can say that I have colleagues who don’t feel good about it because of that, because it’s not perfectly lining up.

                                                So they want to stick with what they’re used to. I have other colleagues that love it and they don’t care if it lines up or not. They feel like the advantages are so great, the studies where they’re validating it, that they’re just using it and they’re recalibrating their clinical sensibilities to the device, to the new data. For me, I’m used to just a lot of data, because as a SIBO specialist, I ran tests all day long every day. I need to see a lot more of their tests until I decide fully what I think of it, but I’m favorable towards the advantages that it has to offer. So what do you think, Ben? Have you tried it?

Dr. Weitz:                            I’ve got one now and I just started fooling around with it. I don’t know yet. I have a couple of patients that are going to be doing side-by-side and I’m curious.

Dr. Siebecker:                    Me too. The other thing that people should note is that to get the parts per million, practitioners can get that. You just have to ask them and sign up for the clinician’s dashboard, I think it’s called. So that’s a website you can go to that’s connected where you immediately see the results in parts per million. They have graphs and things like that, because otherwise, you’ll get the fermentation score. So that’s the one drawback for patients who are using it. If they do a formal SIBO test, they’re only going to see a fermentation score. Someone needs to be a practitioner to get that clinical dashboard and see the parts per million. That’s a limitation that I’m not fond of but they know that, and I’m sure they’re doing whatever they need to do legally. Who knows? Maybe it’ll change.

Dr. Weitz:                           Do you often order a stool test as well to look at the microbiome with your SIBO patients?

Dr. Siebecker:                    Well, I’m not in practice now, but when I was, I wasn’t running microbiome tests. It was like before that became a big hot thing. But I did run functional stool tests a lot, but not microbiome once. Tell me where you’re heading with this one. Have you been doing it? Are you correlating things?

Dr. Weitz:                           Yes, I do. I regularly do a stool test and I like to see what else is going on in their gut. It seems to me a lot of patients with SIBO also have other issues.

Dr. Siebecker:                    Well, that’s for sure. I mean, personally, I think when someone comes in and you suspect that they would have SIBO, you should run expanded screening blood work, the SIBO test, and a stool test. To me, that’s just the fundamentals. It would be sure great if you could also run a really good hormone test.

Dr. Weitz:                           Right, absolutely.

Dr. Siebecker:                    But for certainly stool and breath, because yeah, we have to see what’s happening in the large intestine as well.

Dr. Weitz:                           Yes, exactly. So I talked to several practitioners who feel that the bacteria that caused SIBO are migrating up from the colon. It’s my understanding that Dr. Pimentel originally felt that that was the case, but that current data doesn’t really indicate that that’s the case. What do you think about that?

Dr. Siebecker:                    Yes, that’s my understanding. Ben, I just have to say for anyone watching, I don’t know why my face looks so red. I see it on the screen, and Ben was saying he looks orange. We tried to adjust our light beforehand. I don’t know what’s happening. So sorry about that.

Dr. Weitz:                           It’s okay.

Dr. Siebecker:                    Because I just looked over and saw myself. I’m like, “Literally, I have a sunburn.” I don’t know what’s happening. Totally, that’s my understanding. I was never of that belief that it was a back migration. Even though so many articles and studies said it, that just didn’t make sense to me. Then as Pimentel’s research continued, he came to the same conclusion just as you said. At one of our SIBO symposiums, we used to have SIBO symposiums each year at NUNM where I teach. He said that. He said, “Now I think the majority is it’s there in the small intestine already at low levels and then it overgrows.” So I was thrilled because I felt validated. That is my understanding. It is possible some could come up, but I don’t think that’s the majority of what’s happening. So yeah, I think it’s just overgrowing. It’s already there.

Dr. Weitz:                            There seems to be some studies correlating some of the bacteria that appear in the mouth with the bacteria that end up that caused SIBO.

Dr. Siebecker:                    Yeah, that’s interesting. I’m so sorry. I forget the main researcher’s name. There’s one researcher that’s been working on that premise the whole time I’ve known about SIBO like 15 years or more, and now others have been following in his footsteps. So there’s some little group that is into that thinking. They like to separate oral-like bacteria SIBO from small intestine bacteria SIBO. I don’t think Dr. Pimentel is on that train. I don’t think he’s thinking that way. So that’s like an offshoot of a different thinking. Think it’s Dr. Bohm. We had him come speak at one of our conferences one time. So very, very interesting.

Dr. Weitz:                            Currently, what are the best ways to stimulate GI motility? Do you have any experience with Dr. Satish Rao’s vibrating device?

Dr. Siebecker:                    Oh yeah, that is the coolest thing. The vibrant capsule is just so amazing.

Dr. Weitz:                           Which I don’t think is on the market yet.

Dr. Siebecker:                    It is.

Dr. Weitz:                           It is on the market.

Dr. Siebecker:                    Yeah, it is on the market. I can’t remember exactly when, but it’s been out for a good while now. I haven’t used it, but I’ve talked to a couple colleagues who have. As with anything, some people have amazing results and other people it just didn’t do the job. For anyone who doesn’t quite know about this, this is a non-drug treatment for chronic constipation, really meant for the patient where typical treatments don’t work. Actually, laxatives don’t work. Various medicines don’t work. Prosecretory agents, Amitiza, they’re just not doing the job and you’re at your wits end. You could bring this in. Now, I think you could bring it in even before that. If somebody really has chronic constipation, how nice for them not to have to swallow anything.  So this little pill, it’s timed and it’s timed to just give this very gentle vibration when it would be hitting the large intestine. So anyway, in one patient for a colleague of mine, it was an absolute miracle game changer, insane constipation that nothing would do anything about. This gave her the urge and she goes naturally now normally. Another colleague, it just didn’t work for them. So I guess you have to find the person it’s going to be right for, but I think it’s so great we have this option. So that’s a wonderful thing for stimulating large intestine motility. Yeah.

Dr. Weitz:                           How long does it work for?

Dr. Siebecker:                    Oh, I think you take it five. There’s five capsules you take in a week.

Dr. Weitz:                           Okay.

Dr. Siebecker:                    So it’s almost like a daily thing.

Dr. Weitz:                           I see. Okay.

Dr. Siebecker:                    Yeah. It’s not inexpensive either. I know they had an introductory price. Since it’s new, it hadn’t yet been covered by insurances. So I know that I think in both these cases they were paying out of pocket. So let’s hope it gets covered by insurance and the price becomes better, but in a certain situation, it’s going to be the right fit for some people.

Dr. Weitz:                           What would you say is the most effective drug for motility and nutritional product for motility?

Dr. Siebecker:                    I guess it depends on what kind of motility we’re talking about.

Dr. Weitz:                           Okay.

Dr. Siebecker:                    If we’re talking about large intestine motility meant to create a bowel movement, in essence, a laxative, I have my favorites, my favorite supplement. It’s not a stimulant laxative. So it’s not actually creating movement. That would be magnesium oxide or magnesium citrate. I like osmotic laxatives for actually stimulating movement in the large intestine. Many people like the prosecretory agents, Trulance, Ametiza, Linzess. They’re tricky. So magnesium can be tricky too. You have to make sure you’re getting the right dose at the right time or it could be too strong, but some people, that’s a game changer for them. I’m not the hugest fan of stimulant laxatives that are natural, but many people do like them, senna, cascara, aloe, rhubarb, things like that.  But then we could move to the class of drugs that are prokinetics and they’re really aimed more at and natural agents, the upper GI. So more like the esophagus, the stomach, and the small intestine. So those are used more for achalasia, gastroparesis, and for the migrating motor complex in the small intestine. I mean it’s hard to say a favorite, but I would say probably the most effective would be prucalopride, which is still this Motegrity in the US. Amongst all the gastroenterologists I’ve spoken to, they say it’s the best they’ve ever used. Almost no side effects. I mean, people can have reactions, but no adverse concerning side effects.

Dr. Weitz:                           It certainly seems to be Pimentel’s favorite.

Dr. Siebecker:                    Yeah, many, many gastroenterologists I’ve spoken to. Yeah, because many of our prokinetics that were available had cardiac risks and extrapyramidal symptoms, all sorts of awful things. There’s so many practitioners that think prokinetics as a category is dangerous and that’s not so. There are safe options, but that’s really probably the best there. Naturally, the main things we have is Iberogast, which is like a combo herbal product. Actually, there’s like a dupe now for that because it can sometimes be hard to get.

Dr. Weitz:                           Yeah, very hard. Yeah.

Dr. Siebecker:                    That’s by Heron Botanicals, which is a company from fantastic herbalist and naturopathic doctor. They have a product called Gut Motivator, and it uses pretty much all the same ingredients, except I think there’s fennel instead of something else. I can’t remember.

Dr. Weitz:                           Oh, interesting. Gut motivator.

Dr. Siebecker:                    Gut motivator. It’s in glycerin base, which is nice because it’s easier to take straight from the dropper and it tastes a little sweeter. The only problem with it is that they’re still ramping up. They grow a lot of their own herbs and they’re so ramping up their supply of Iberis amara, the main ingredient that gives its name. So they’re only selling to practitioners at this time. So it’s not ready for the general public, but it will be eventually.

Dr. Weitz:                           Is that available through Fullscript?

Dr. Siebecker:                    No, not yet. I’ve asked them to carry it, but you have to get it from Heron Botanicals right now. So just so people know there’s another option. Some of my colleagues are reporting very good results with it, so I’m glad to hear that. But the other really nice prokinetic is for the upper GI’s ginger. So many studies on that. By the way, so many studies on Iberogast. I mean, it’s been around for a long time, amazing studies where head to head against Cisapride and metoclopramide, other prokinetics where it did just as good, if not even better. So amazing. But then ginger also has excellent prokinetic ability, and we have all of these companies now that put it in their formulas. I call them the ginger-containing prokinetic formulas. There’s six of them.

Dr. Weitz:                           Yeah, we use motility activator a lot.

Dr. Siebecker:                    Yeah, that’s a good one. There’s a lot of good ones. So those are some options. I mean, there’s probably other options, but that is generally good.

Dr. Weitz:                           So we know that patients with IBS, 60 to 70% have SIBO. Then the question is what about the other 30 or 40%? So how often do you think patients have SIFO or fungal overgrowth, and what’s the best way to diagnose that?

Dr. Siebecker:                    I think a good amount do. I can’t remember the statistics from Dr. Rao’s studies on this, but I think it was at least a third also have it, if not more. It depends on your patient population, but I think a lot of us see that a lot. When I was first practicing for SIBO, for years and years, I was looking for yeast and a majority of my patients did not have it at the same time as SIBO.

Dr. Weitz:                           How were you trying to look for it?

Dr. Siebecker:                    Okay, so I don’t think the testing options are great. The gold standard is going to be endoscopy, which is impractical.

Dr. Weitz:                            Right.

Dr. Siebecker:                    Yeah, but I was honestly running three tests because people were coming to me as a specialist. I was running the urine organic acid test. That can’t distinguish between small or large intestine, but it can show indicated and overgrowth by metabolites. Then I would run a functional stool test and look for actual overgrowth in the stool, and then I would run a blood test. The Candida Immune Complex and Antibody test, Quest and LabCorp have that. So I would run all three. Then with the blood test, it doesn’t really tell you whether there’s an overgrowth. It more so tells you if there’s a hypersensitivity. There could be an overgrowth, but it could also be that there’s a normal amount of yeast and their immune system has decided to react against it.  So you are telling different things from this, but I lost confidence in doing those tests. I never felt very sure about what was the best and right way. I can say that you recently had Dr. Morstein, I know. She likes to use the questionnaire from The Yeast Connection, the old Yeast Connection book by Dr. Crook, which I think you can see the questionnaire online. She likes to say that it has been shortened. That questionnaire has been shortened to five questions or seven questions, and she doesn’t think that’s adequate. So she likes just use the questionnaire. I always like to ask other practitioners what do they feel confident with in testing. I don’t think we have a perfect way to test.

Dr. Weitz:                            Well, I feel like with the stool test, since it usually does not come positive that when it is positive, I feel pretty confident that there is candida there if it comes up on the stool test.

Dr. Siebecker:                    I would agree.

Dr. Weitz:                            Organic acids seems to come up too often positive potentially. I’m a little skeptical. I haven’t used … I know Dr. Ilana Gurevich, she loves the candida antibodies test.

Dr. Siebecker:                    The blood one. Yeah.

Dr. Weitz:                            Yeah. I haven’t done that test though.

Dr. Siebecker:                    Yeah, I mean, I used to run them all. I can’t remember what happened, but I think I had somebody with a yeast overgrowth infection vaginally and the organic acid test, maybe it wouldn’t because maybe that’s only telling you the intestinal situation. I don’t know. Then the blood test didn’t come positive and I just thought, “Oh, this is hard.” Maybe it wouldn’t, but I don’t know. Just somewhere along the line, I lost confidence and I stopped doing them all. But I do think that to your point, what are the other things that can be IBS that aren’t SIBO?  A lot of times people have other things at the same time. Yeast is really common. I mean, I’m saying that without having a proper way to diagnose it, but it’s like because then you treat it and they get better. Then parasites also I think are very common. I mean, I’ve written differential diagnosis charts on this, and you just get tired of including things. It’s like 40-

Dr. Weitz:                           By the way, I just saw or listened to your podcast that you did with Nirala Jacobi.

Dr. Siebecker:                    Is it out? I didn’t even know.

Dr. Weitz:                           It’s out. I listened to it this morning and it was great podcast. Nirala Jacobi was really good too.

Dr. Siebecker:                    Oh, good. I really enjoyed that.

Dr. Weitz:                           You guys went through all of these different possibilities, and you made a really profound statement, which was that you find that practitioners often find what they look for.

Dr. Siebecker:                    That’s exactly right. It’s like, “Well, what are we testing for? And then what do we know?”

Dr. Weitz:                            I’m a mold expert. I’m looking for mold and I’m finding mold.

Dr. Siebecker:                    That’s right, because it’s what we choose to test for. But then, of course, what if our tests don’t turn anything up? Well, then we got to look over in the area we don’t normally look, but I mean, what are you supposed to do? Also, you can’t test for everything. People can choose their own path where they want to put their attention first. If that works out, great, and if it doesn’t, then we have to look other places.

Dr. Weitz:                            A similar question, which is it’s known that so many patients who get treated with rifaximin or herbal antimicrobials don’t get completely better after one round. Why do they need multiple rounds? Is it because we haven’t effectively reduced the microbes, we haven’t killed enough of them, or is it that they grow back? Is it because there’s biofilms and we can’t get to them? Is it because there’s layers of problems like you’re mentioning other things? So maybe they have SIBO and they have dysbiosis, and we have to correct both of those. Why do we think it takes repeated rounds?

Dr. Siebecker:                    I mean, all of that can be true. So yes, yes, yes. But I think predominantly, what my experience has been is it’s just that it’s different when we have an overgrowth versus an acute infection that we’re used to thinking of where there’s a prescribed acute infection and we know 10 or 14 days of an antibiotic is going to take care of it. Because here in SIBO, we have these levels of which the overgrowth can be and we can see the gas can be 150 or something. In another person, it’s 20. So it seems to correlate the amount of rounds with the overgrowth amount. The gas is a representation of how many bacteria are grown. So I think it just takes time. Basically, it’s thinking of a chronic infection, even though it’s not technically an infection. We treat until we get effects.

                                                We just have to keep going and going at it. So then the question is why can’t we just use one treatment and then just treat for however long it takes until it goes down? For some people, that does work, but unfortunately, what I found happens so often was the treatment would peter out. Its effect would peter out and it would stop working. You’d know because they would have had some improvement and then their symptoms would come back while they’re even taking it. So it’s like it just couldn’t do anymore. It did all it could do. So then you just stop. At that point, I would retest, but you have to switch. You use something else. Thank gosh, we have a lot of tools in our toolbox.

                                                So then that’s the next round. If a patient is sensitive enough to pay attention to these things, some people are, some people aren’t. I think great. If they’re still getting effects, you can keep them on something until it’s not working anymore. But not everyone is paying attention like that or wants to. So that’s why we need, I think, the multiple rounds. Now, what about the biofilms, anti-biofilms? I think that that’s another thing to think about for sure. My experience was that I used a lot of anti-biofilm products for a long time treating SIBO, and then I wouldn’t use them in other people. So I had a good comparison and I was only using the enzyme-based anti-biofilms and the EDTA type of products. I could detect no difference at all in anything at all.

                                                Really, my intention in using them was to try to prevent as much relapse. That’s what I was hoping for, and that was a bust. But I can tell you that Dr. Ruscio did an in-office study on that and presented this at one of our SIBO symposiums. He found that statistically on paper when using the anti-biofilms, it reduced hydrogen gas a little, but he could not detect that clinically at all. There was no clinical representation of that. It was a statistical on paper thing. So just continuing down with this story, I was just very disappointed in anti-biofilms. But then I spoke to Dr. Paul Anderson, this was years and years ago, and he’s an anti-biofilm expert.

                                                He had treated a lot of conditions with very serious infections, and he had done a lot of research and found that bismuth thiol products were very good anti-biofilms and he thought the best. Now, he has an over-the-counter option, but at that time, he just had a prescription formula. So I used that in some of my patients and I found it made a difference. Where it made the difference was in relapse. I didn’t necessarily see as much of a difference in not needing multiple rounds. I think theoretically, it could make a difference. I just didn’t observe that at the time. So I like to recommend if you’re going to use anti-biofilm in SIBO that you use the bismuth thiol. I just couldn’t see any effect for three years of using the other products.  Maybe other people have different experience, but it was a dud for me. So I would say it is definitely worth an option and maybe it could reduce. I know when you’ve had Pimentel on your show in the past, he’s talked about, and even just recently I was doing a Q&A with him, finding that some of the overgrown microbes live in a biofilm along the lining. I know you’ve asked him and I’ve asked him, “Well, then what about anti-biofilms?” I think he’s waiting until he would present research whether it would be truly effective or not.

Dr. Weitz:                            I know particularly the methanogens seem to live in this mucus layer, which is a biofilm that it’s got to be hard to get to those. We know that treating methane seems to be more difficult than hydrogen.

Dr. Siebecker:                    What has your experience been with anti-biofilms?

Dr. Weitz:                            Sometimes I think we get a benefit and other times we don’t. So I haven’t done any systematic analysis of it, but I get the impression that we get some benefit from it.

Dr. Siebecker:                    That’s good. Do you use all the different types or just the bismuth ones?

Dr. Weitz:                            Yeah, no, I use the enzymes. I often start with the enzymes and then use the bismuth ones depending upon exactly what’s going on. I’m a little nervous about using bismuth for long because it is heavy metal.

Dr. Siebecker:                    Yeah, that’s right. We talked about that before. The good news with the bismuth thiol is… Well, this is in the context of treating hydrogen sulfide SIBO is bismuth helps with that, but the bismuth thiol are a much lower dose than what has been studied bismuth for hydrogen sulfide. So I like that we can use a much lower dose with those bismuth thiol ones.

Dr. Weitz:                            Speaking of treating hydrogen sulfide, in fact, any new treatments for especially herbal nutritional for treating SIBO? The traditional antimicrobials that are used are berberine, oregano, allicin. Any new guys on the block that seem to be hitting the radar?

Dr. Siebecker:                    Well, I’d say that bismuth. I mean, that’s not really that new, but it’s worth really mentioning. Other than that, well, Atrantil, we’ve been using that for years. That’s a combo product for methane. I did a bunch of before and afters. That’s not really new, but just mentioning it, right?

Dr. Weitz:                            Correct.

Dr. Siebecker:                    I haven’t really been using anything new, but Dr. Hawrelak has reported using perilla and tincture of oregano, which we already were using oregano, but he actually was reporting that he found that that worked on methane. I had used oregano for methane. I thought it was going to give me a result, and then in the end, it didn’t pan out. So I just wonder, “Huh? Could the tincture be the difference?” Because I really never did see much of an effect from oregano for methane, but perilla is a new one for me. I haven’t used it. So he’s using that one too, but he’s using that only when the standard things aren’t doing the job.

Dr. Weitz:                            Then some of the products have oregano and they also have thyme. The thyme oil seems to be… I find sometimes very beneficial.

Dr. Siebecker:                    Yeah, I mean, that’s a potent.

Dr. Weitz:                            It’s potent. Yeah.

Dr. Siebecker:                    The one problem with that is like what’s in the CandiBactin AR, but the one problem with that is if you’re using CandiBactin AR and BR, that’s great. You’re using berberine and oregano, which is our classic thing that we always use for hydrogen, but there’s nothing in there for methane. So always remember you have to add something in for methane, which would be the allicin-

Dr. Weitz:                            Like allicin.

Dr. Siebecker:                    … or the atrantil. Yeah.

Dr. Weitz:                            Right, absolutely.

Dr. Siebecker:                    If you have hydrogen sulfide, you add in bismuth. We also found high-dose oregano works good for hydrogen sulfide, but you’d probably want that separate then.

Dr. Weitz:                            Right. There are so many patients in this country right now taking GLP-I agonists like Ozempic for weight loss. We know that the way this works is by slowing GI motility. So when all these patients are done, when they’re now suffering with POS, that’s what I call post-Ozempic syndrome. Now their weight is ballooning up because they never changed their diet. Are we going to have a tsunami of patients with SIBO? By the way, I asked Dr. Pimentel about testing patients with Ozempic, and he said, “It’s just a nightmare. Their microbiome is so messed up.”

Dr. Siebecker:                    He said the same thing the other day when I was interviewing him also, I asked him the same question. I wanted to know what he thought. What is he seeing? Yeah, he said, it’s really hard to test it because nothing leaves the stomach. Dr. Morstein had said she is testing… Because she’s a diabetes expert, and she had said she’s testing patients the morning of the day they were going to do their next dose. So it’s like it’s been a week since they’ve taken their dose and on that morning, and she says it’s going fine. I asked Dr. Pimentel about that, because when you look at the studies, it takes weeks before the medicine becomes steady state or leaves the body.

Dr. Weitz:                            So Mona is giving him a SIBO test?

Dr. Siebecker:                    Yes.

Dr. Weitz:                            Okay.

Dr. Siebecker:                    Yeah, yeah, a SIBO test. Yeah. So my concern is, is that enough time? She said, “That’s working for her,” but Pimentel said, “Well, no, the reason you give the dose on seven days before it gets too low, you don’t want people bottoming out.” So he has a very hard time getting accurate results testing anyone on Ozempic. To your point, yeah, there’s a real concern that people could develop SIBO. Of course, we have no data on us at this time, but it’s a real concern. The thing that it seems to do is slow the stomach. Does it also slow the small intestine?  I think so. But the stomach itself, the migrating motor complex, one of the forms or I guess one of the types of migrating motor complex starts in the stomach and continues through the small intestine. That is, from what I’ve read, the more powerful migrating motor complex. That’s our protective wave. That’s our number one body’s protection against SIBO is the migrating motor complex in the small intestine. So I believe it will turn that off. So it’s a real concern. It’s a real concern.

Dr. Weitz:                            Does the motility come back to normal typically with patients once they stop Ozempic?

Dr. Siebecker:                    I don’t know. I don’t know that. I don’t know if anyone’s looked at that. I bet you there’s people that could report about that just in their sensibilities, but I would think it would. Because when you hear about people’s hunger comes back after they get off.

Dr. Weitz:                            That’s why we tend to gain weight again.

Dr. Siebecker:                    On the other hand, you have to weigh it out against what someone’s facing. I would never want anyone to have SIBO, good lord, but diabetes can be fatal. So it depends on how much it’s needed. I guess also how it’s affecting that person. I know there’s people doing things with compounds where they’re going much lower and still getting good effects on blood sugar and things like that, but these are early days, but it’s a real concern. One thing I want to share that I heard from one doctor who said about the people gaining weight afterwards is that what they’ll do is they’ll just give people a much, much lower dose and help them to hold their weight for… If I’m not mistaken, I think she said one or two years.  It might’ve been two, because that’s how the body sets its set point. So if you could hold that, your goal weight or whatever for one or two years. I’m sorry, I don’t remember exactly. This was an expert on this, a doctor, and then they’ll take people off, but they’ll put them way low. That was a fascinating thing to hear about, just to try to work against that problem.

Dr. Weitz:                            One more question on the treatment, a lot of functional practitioners, some of them will also incorporate an immunoglobulin product as part of their SIBO protocol. Some do it specifically because I tend to use it when I see that the secretory IgA is low on the stool test, but some will use it all the time automatically, something like SBI Protect or MegaMucosa. These are also known to bind with the endotoxins and potentially might help with the eradication.

Dr. Siebecker:                    I think it’s a great idea. I love serum bovine immunoglobulins, or for people who are vegetarian, they can do colostrum that has high IgG. I love it. I spent some time really looking into all the studies and just as you said, excellent for LPS. It has straight antibacterial properties. It can prevent food poisoning. I had an experience where I was traveling in Mexico, my husband and a group. We took it the whole time and we didn’t get food poisoning when the other people in our party did.

Dr. Weitz:                            Oh, interesting, because that question comes up a lot is I’m going to Mexico or wherever I’m going and I want to try to avoid getting food poisoning again. Dr. Pimentel’s answer is just to take antibiotics.

Dr. Siebecker:                    Take a half a pill of Rifaximin is what he recommends. I’m not sure that what I did is enough for everybody. What other colleagues will say is take one Allimed pill or two Allimed pills.

Dr. Weitz:                            Yeah. I’ve had patients take one Biocidin.

Dr. Siebecker:                    Yeah, yeah, yeah, things like that. But this worked for me and I was so grateful. It does a lot of amazing things. I mean, it can help with lipids, the IgG. I mean, it’s just so important, anti-inflammatory. It’s expensive is the problem, but I think if someone can afford it, it’s a great thing to have on board for so many reasons. Not just SIBO.

Dr. Weitz:                            What about the use of probiotics for SIBO? A number of practitioners use probiotics. We both know one prominent practitioner who says that’s the first line treatment. Everybody should get three probiotics, Lacto bifido, Saccharomyces boulardii, and a spore based. Some practitioners feel spore based is good because it won’t add to the bacteria in a small intestine. They’re concerned that even giving antimicrobial herbs or antibiotics, we might damage the microbiome. So why don’t we try to beef up the microbiome at the same time? And then we have Dr. Hawrelak who found specific strains like Lactobacillus reuteri, DSM 17938 that reduces methanogens.

Dr. Siebecker:                    Yeah. Okay. So here’s the deal. It’s all good. Then of course, we didn’t mention this. I think still Dr. Pimentel is not a fan of probiotics.

Dr. Weitz:                            Not at all, but part of the reason he’s against probiotics is because of all these meta-analyses that lump in all these different studies on probiotics, and they’re all using different probiotics. They don’t even report on which particular strains. You certainly wouldn’t throw in all antibiotics and say, “Antibiotics are effective for SIBO.” You test a specific one, and here we’re throwing in all these probiotics as if it doesn’t matter which strains and how much of each. Then we go, “Oh, probiotics work.” So he has a problem with that.

Dr. Siebecker:                    I would agree. That is a strange thing, isn’t it?

Dr. Weitz:                            It is.

Dr. Siebecker:                    Okay. So we’re fortunate in that we have a whole bunch of studies on probiotics and SIBO. I mean, right now, I haven’t counted recently, but there should be about 35, maybe even more than 35 studies, which is a surprise to a lot of people that there’s that many. There’s been reviews of these. The most recent one was I think 2017. So this gets quoted a lot, and it’s really astounding what it showed. It showed like a 53%, even with some products, actual eradication rate of SIBO. So this gets everyone excited. Oh, my God. Can I use probiotics for my main treatment of SIBO? The issue with these studies is a lot of them, and let me just preface, here’s the problem, is that clinically, it’s pretty rare for any of us to see those types of results. That’s frustrating.  We want to see these results. Even if you go out and you get the exact same product that was used in a study that had a fantastic decontamination rate, we don’t get those same results. It’s really frustrating. So one thing is that a lot of these studies were small. A lot of them were done on certain conditions with certain age groups. Just as an example, pediatric short bowel syndrome. That may not translate to an adult with IBS SIBO, who doesn’t have an altered anatomy. So maybe that’s what some of the differences, but one way or the other… There haven’t been any duplication studies on any of these.

                                                Maybe that’s why we’re having a clinical difference, but the evidence in the studies is excellent. Certainly, it shows that probiotics can lower gas levels, can lower symptoms, and may even be able to eradicate SIBO. What probiotics? In these studies, just as you said, for the general IBS studies, they use every different type, all different kinds of lactobacillus, all different kinds of bifidus, all different kinds of spore bacterias, and Saccharomyces boulardii. Here’s the thing, all of those different types showed benefits. As you mentioned, Lactobacillus reuteri, everyone says it different. That was amazing for methane. I think it’s like 55% at eliminating methane, but that same strain has been studied to help diarrhea.  So we think of methane with constipation. That same one was also studied, showing reduction of SIBO when you’re on a PPI. So really, really interesting. Bacillus clausii, the spore has excellent studies for hydrogen. Then there’s a lot of studies on combinations where they use yeast and lactobacillus and bifidus or spore and everything. But what are we supposed to do when we try it and then it doesn’t work? So basically, the study also for IBS, they’re pretty good too. I think it’s fine. A good idea to try probiotics, first line, I guess you have to decide where you are in the patient in the journey, because first line, I think that’s a great idea for someone who’s having digestive trouble.  But if they’re suffering with really bad symptoms for really long time, you may not want to do that first. A lot of the studies show that it takes three months to get these results. Well, if someone’s in real acute distress, we may not want to wait that long. So it probably depends on the circumstance. For some people, I think it would be a great first line. I think it’s a great thing to throw in and try at any point. I personally like to try probiotics before I’ve gotten somebody all the way better and they’re all perfect.

                                                I know that what most of our training is the four Rs, and you do the probiotics when you’re done at the end. I did that in the beginning when treating SIBO and I had a lot of problems because of all these multiple rounds that I needed to do, it could sometimes relapse and it would take me a while to get someone all squared away. It might take me a year and then I give them probiotics. It’s like I rock the boat and they would oftentimes have a bad reaction. I don’t want to rock the boat when it’s all good. So I like to start them on probiotics during treatment, or at least before I’m all finished with everything. People have a different ideas about that, but I just think if you do it, then if somebody has a reaction or something’s not right, you have time to fiddle.

                                                You’re in the middle of using antimicrobials. So then which ones? I don’t know. So many different ones seem to have worked in these studies. That’s probably why Dr. Ruscio likes to give those three all three together just in case cover all your bases. The problem also that I didn’t mention is that many people have a bad reaction to probiotics. So that’s where it is probably a good idea to make sure you’re trying the different ones. It might not have a bad reaction to yeast or to spore if they had Lactobacillus.  A lot of people have histamine intolerance and then there’s all people talk about, “Oh, well, there’s some probiotics that are safe for people with low histamine producing,” but then even they can still react. Dr. Hawrelak generally recommends bifidus for people who are sensitive to histamine, but probably that’s going to be very individual. I mean, we know how an individual it is with histamine sensitivities. So that’s an issue too, is that a lot of people can’t handle them, but then they may be able to handle them as they move along in their treatment. So that gets us going on the topic. So tell me what you think.

Dr. Weitz:                            So I was trained with the four R protocol from going all those seminars with Dr. Bland for all those years. I really do miss those. I used to listen to his functional medicine update. We used to get these little cassette tapes and then they were CD of DVDs we would put in the car. Anyway, so I started off doing a four R and then I decided to start adding in probiotics as part of the protocol because I wanted to make sure I didn’t damage a microbiome. That wasn’t really working.  So I went back to the four R program, and it’s a two-phase thing, which is we do the eradication first. Then when we feel like we’ve got the symptoms under control, we start microbiome restoration, rebuilding the gut, rebuilding the gut wall, and use those products. I usually start with the spore-based probiotic. That seems to be the safest. Then gradually expand to other prebiotics, probiotics, and at the same time, we’re slowly expanding the foods that they can eat as well.

Dr. Siebecker:                    That sounds great. So that’s gone well. You haven’t had too many reactions with that.

Dr. Weitz:                           Yeah, that seems to work pretty well, especially when the patients comply.

Dr. Siebecker:                    I mean, my problem is that I saw extremely sensitive patient population, and even the spore ones were… I mean, I used to make a joke about a very popular spore-based combination probiotic, and I said, “It should just be relabeled die off because my patients would react so intensely to it.” But that’s just the sensitive group. So it’s good to hear that your patients are tolerating that well.

Dr. Weitz:                           I know Pimentel had a negative report about lactobacillus.

Dr. Siebecker:                    Well, yeah, they found in one of their studies when they were really assessing what was overgrown in the microbiome, and then they figured out this new assessment for an imbalance or dysbiosis in the small intestine microbiome where they identified disruptors, basically certain bacteria that if they would get too overgrown, they would disrupt the entire ecosystem. They classified lactobacillus one of them. It was just this one little sentence in one of these studies, and we all noticed it. We all started asking about it, and that’s all they can say. They haven’t said anything else.  So all these years following this research as it comes out, I don’t get too excited about one thing or another. I just wait until more information comes out. I mean, look, we’ve been using lactobacillus in our patients forever with good results, unless they have a reaction and then we don’t use it. I’m not worried. We’ll just see what the research shows in the future. Maybe there’ll be some very specific things, but otherwise, I’m not going to worry about it.

Dr. Weitz:                           I was reviewing some of Pimentel’s recent papers, and one of them was the one where he looked at the methanogens and hydrogen sulfide producing bacteria. There’s this interesting information, I wonder if we have anything to do with it, which is that there’s certain bacteria that produce the hydrogen to feed the methanogens. So we have Ruminococcus, Christensenella, and then we have these Enterobacteriaceae that feed the hydrogen sulfide bacteria. It seems like something important, but is there anything we can do with that?

Dr. Siebecker:                    Yeah, this is key. These are the syntrophys. So this is basically what is creating the hydrogen for methanogens or hydrogen sulfide. They call them the syntrophys. What’s really amazing about this is that I and they, everyone just assumed it was the overgrown standard hydrogen bacteria, E. coli and Klebsiella. So we thought, “Okay, we’re aiming at that.” So basically, this is a new target for our treatment, and I haven’t actually spent time going through PubMed looking at various articles on what kills those things, what MIP levels. I haven’t done it yet because what we have works. So we’ve been using it for so long of all the before and after tests.

                                                We already know it works, but what I think is going to happen is, well, I know they’re doing research on it, Pimentel and Rezaie and all that. I think they might have something at this DDW, which is the big gastroenterology conference that happens every year in the spring. So 2024, I think they might have, we’ll see, some treatments to reveal aimed at those. If it’s not this year, it’ll probably be next year. I’m so glad you brought it up. I think that this is going to be the wave of the future. We probably get more specific at targeting when we’re treating methane and hydrogen sulfide, what treats, what aims at those syntrophys. Then they had a paper that came out in December and I don’t have all these organisms memorized, but they had this sequence now where it’s like this leads to this leads to this. It was like a further piece.

Dr. Weitz:                            Really?

Dr. Siebecker:                    Yeah. So sorry I didn’t bring it up in front of me or I could read it to you. For anyone who’s interested, I do a quarterly newsletter. You could just sign up at SiboInfo and I put all the research and I put comments. So I put a big thing all about it, because it was really fascinating. I have yet chance to speak to Dr. Pimentel to ask him to publicly to explain this, because that seems like another target actually. They’re just learning more and more of the specifics of what is overgrown. The whole point is this is going to refine our treatments.

Dr. Weitz:                            Right. Yeah. I’ll make sure to review that next time before I talk to Pimentel. I think they dropped the statin for methanogen.

Dr. Siebecker:                    He’s still working on it.

Dr. Weitz:                            Oh, he’s still working on it. Okay.

Dr. Siebecker:                    Yeah, he hasn’t fully dropped it. It was a disappointment, but so for anyone who doesn’t know, he was working on enterocoded, not exactly like a statin that wouldn’t absorb into the blood. So that you wouldn’t get all those other effects. Statins, it works like Atrantil. It inhibits methane production. It actually disrupts an enzyme in the methanogen, so they can’t make methane. So this was another way to treat, but it just didn’t give them the results they wanted, but they are still working on it.

Dr. Weitz:                            I wonder if any natural practitioners are using red yeast rice for the same purpose.

Dr. Siebecker:                    Oh, yeah. We asked Dr. Rezai about that, and then he said that in a few patients it does work and then in others it doesn’t.

Dr. Weitz:                            Oh, interesting.

Dr. Siebecker:                    Yeah, exactly. That’s all the first thing we think about. Could we just use red yeast rice for this, like an alternate? Atrantil does the same thing.

Dr. Weitz:                           Okay.

Dr. Siebecker:                    Yeah.

Dr. Weitz:                           Interesting.

Dr. Siebecker:                    Actually, I find Atrantil to be very hit or miss, probably just like red yeast rice. It’s in some people it hits like a miracle.

Dr. Weitz:                           Are you using a recommended dosage or are you using a higher dosage?

Dr. Siebecker:                    Using four to six a day.

Dr. Weitz:                           Oh, I think the recommendation is two a day.

Dr. Siebecker:                    Oh, yeah. So yeah, two is what we use for maintenance. Once you get your effect, then anywhere from one to three as your maintenance, because you still need to keep inhibiting that enzyme. Keep inhibiting the methane production.

Dr. Weitz:                            So you’re doing two or three twice a day.

Dr. Siebecker:                    Yeah, that’s right, for standard treatment round for a month. But here’s the thing, I’ve seen before and afters where that just works like a normal herbal antibiotic lowering methane in the same way you would expect, but there’s also these miracle cases that sometimes happen. The real miracle cases that I see are probably going to either be with Rifaximin or Atrantil and then they don’t work like that for the majority, but you get these miracle cases. You always remember them. But what will happen is for some people within just a few days, usually within four to five days, the Atrantil just has removed all constipation just completely. I mean, people in their 70s constipated for they’re entire lives gone in four days.

Dr. Weitz:                            Wow.

Dr. Siebecker:                    But then I find that the miracle, if it’s going to be a miracle like that, it’s usually pretty quick. My frequent educational cohort, Shivan Sarna, she interviewed Ken Brown. She interviews him a lot. He’s the creator of that. He said that he’s seen miracles happen months on. I haven’t. Usually, when you’re doing it for me, when I see him doing it over months, you’re just getting those incremental reductions in gas like you would anything else. I don’t consider that a miracle.

Dr. Weitz:                            Yeah. I haven’t seen any miracles.

Dr. Siebecker:                    Complete and fast. So maybe red yeast rice is the same. It’s like either it works or it doesn’t. That one particular approach I find is a bit more hit or miss.

Dr. Weitz:                            Right. If it lowers your cholesterol at the same time, probably not a bad idea.

Dr. Siebecker:                    You can get other benefits.

Dr. Weitz:                            Have you used any peptides? Some people use BPC 157 supposedly to help heal the gut lining, to help heal leaky gut.

Dr. Siebecker:                    I haven’t used it in patients, but when I found out about it years ago, I was enthralled and I brought in a whole bunch of people to interview for various summits and educational events, Dr. Bar and others speaking.

Dr. Weitz:                           I know he was using it a lot.

Dr. Siebecker:                    He was, speaking very favorably about it. I mean, when you read about it, it seems like a perfect match. Again, it’s expensive, right? I’ve heard some people say it was wonderful for them and not much for others. So I don’t have a ton of experience with it. I was very interested. Did you try it a whole bunch?

Dr. Weitz:                           No, not a whole bunch because of the expense. If I already have patients on four or five different products and then you throw in a product that’s $150 to $300 for a month’s supply-

Dr. Siebecker:                    It’s a lot.

Dr. Weitz:                           It’s a lot.

Dr. Siebecker:                    Yeah. I haven’t heard enough feedback to make me think that’s worth it full bore for most people.

Dr. Weitz:                           When I’ve used it, I found around four capsules a day was about the right dosage, but that means you’re going to go through a bottle in two weeks, so that’s 300 bucks a month.

Dr. Siebecker:                    I mean, I tried it on myself. I always try everything almost, and it was meh, but that’s one person.

Dr. Weitz:                           Yeah, I know. I use it for healing for musculoskeletal injuries as well. I wouldn’t say I’ve seen a lot of miracles, but there seems to be some benefit.

Dr. Siebecker:                    Yeah, and I guess I’ve heard some cases that responded really well.

Dr. Weitz:                           Right. All right. This has been awesome, Allison.

Dr. Siebecker:                    We talked about a lot of different things.

Dr. Weitz:                           We did. Thank you for being so generous with your time.

Dr. Siebecker:                    Oh, it’s been such a pleasure.

Dr. Weitz:                           Tell the viewers about some of your courses and how they can sign up for them.

Dr. Siebecker:                    Oh, yeah. I have a bunch of trainings. If anyone’s interested in learning more about SIBO, I have a full length SIBO training, very comprehensive, 22 hours, got mini trainings on SIBO and testing. I’m doing a testing masterclass here soon. You can find all of this on my website, siboinfo.com that has a lot of information. Of course, signing up for my newsletter. I always send my quarterly newsletter has all the studies. If there’s ever any treatment updates, like in the January one, there was different antibiotics that people are using. I put that in there. So anyway, I’d love for anyone to join me for a training.

Dr. Weitz:                           That’s great. Thank you.

Dr. Siebecker:                    Thank you so much, Ben.

 


 

Dr. Weitz:                            Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five-star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. So many areas I specialize in include helping patients with specific health issues like gut problems, neurodegenerative conditions, autoimmune diseases, cardio metabolic conditions, or for an executive health screen.  To help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way, please call my Santa Monica Weitz Sports Chiropractic and Nutrition Office at 310-395-3111. We’ll set you up for a new consultation for functional medicine, and I look forward to speaking to everybody next week.

 

Dr. Christopher Shade discusses Bioidentical Hormone Replacement Therapy with Dr. Ben Weitz.

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

*Use the discount code weitz15 for 15% off Quicksilver products.

2:02  Quicksilver Scientific offers topical estrogens and progesterone over the counter because the FDA allows topical cosmetics to include hormones below a certain concentration, including an estadiol, estriol, biest, progesterone, DHEA, and a product called DHEA Plus female replacement serum that includes DHEA, pregnenolone, DIM and chrysin to hold back estrogen formation and increase estrogen breakdown, and then some adaptogens, including ginseng, maca, and dong quai.

3:51  Most transdermal cream formulations of hormones are not well absorbed, which is why some Functional Medicine doctors have been using saliva testing to measure hormones. But this may not be because serum or urine are not good at detecting these hormones, but that they simply don’t get absorbed through the skin. When you look at these hormone creams under a microscope, you see big chunks of the hormone that’s never been dissolved, while if you examine the Quicksilver topical hormones, they are dissolved into the oil phase in the center of the emulsion droplets. And then when you put those on, they go all the way through and you can pick them up in the serum. But Dr. Shade pointed out that when you measure estrogen in serum with women using topical hormones, you see levels go up and then down and then up and down as their bodies pull the estrogen into various compartments in the body.  He has found that urine is therefore the best way to measure hormones, such as through a DUTCH test, since you can pick up the fluctuations in hormone levels that occur over the course of the day.

7:50  DHEA.  If you look at androgens in women, like DHEA and testosterone, then these are picked up really well in serum. Quicksilver offers a DHEA product for women with 100 mg of DHEA, which is usually considered a high level for a woman to take, but Chris points out that since they use a nanoparticle delivery system, you’re bypassing the liver and you get way less incidence of the hair growth, hair loss, or acne that women sometimes get from high levels of androgens.  Interestingly, while DHEA converts into testosterone in women, in men it doesn’t convert into testosterone.

 

 



Dr. Christopher Shade is the founder and CEO of Quicksilver Scientific, which has revolutionized the nutritional supplement industry with their innovative nanoparticles and liposomal delivery system, their heavy metal testing, and their detoxification protocols that have become the standard for many for reducing heavy metals and mycotoxins.  The website for Quicksilver Scientific is QuicksilverScientific.com.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111.

 



 

Podcast Transcript

Dr. Weitz:            Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, drweitz.com. Thanks for joining me and let’s jump into the podcast.

                                Hello, Rational Wellness Podcasters. Today, I’m excited to have another interview with Dr. Chris Shade, and today we’re going to be speaking about hormones and hormone receptors. It’s really interesting to think about hormones, and we often don’t think about hormone receptors. We know that there’s lots of potential benefits of taking hormones if they’re needed.  However, if those hormones can’t attach to hormone receptors and those hormone receptors aren’t functioning optimally, then those hormones can’t do the things that they’re supposed to be doing. We’re not going to get the full benefit out of them. Dr. Chris Shade is the founder and CEO of Quicksilver Scientific, which has revolutionized the nutritional supplement industry with their innovative nanoparticles and liposomal delivery system.  Their heavy metal testing and their detoxification protocols have become the standard for many in the functional medicine world for reducing heavy metals, mycotoxins, and environmental toxins. Quicksilver has now added a slate of hormone products as well, as their nutraceutical line of products has become broader and broader. Chris, thank you so much for joining me again.

Dr. Shade:           I’m happy to be here, Ben.

Dr. Weitz:            This is great. I think this is our fifth interview, and I love our discussions because you’re such a deep thinker, and I love diving deep into physiology and science. I was actually surprised to see what that Quicksilver was offering a topical estrogen product, because I assumed that it would require a prescription. So tell me about that.

Dr. Shade:           So does everybody. Lo and behold, I started seeing some estrogen creams and progesterone creams out there. We could go into a Vitamin Cottage and get it. And so I asked my FDA lawyer like, “What’s going on with all this?” And turns out, topical cosmetic laws allow hormones up to a certain concentration. We make a really good nanoserum. And at those concentrations, this stuff works. It goes in and you get circulation.  And it’s able to go in and do bioidentical hormone replacement for you. So we did a estradiol, estriol, biest, and progesterone, and then we have for all the androgens, we have something called DHEA Plus female replacement serum, and that’s DHEA, pregnenolone, with DIM and chrysin to hold back estrogen formation and increase estrogen breakdown, and then some adaptogens, ginseng, maca, and dong quai. And so that together you totally have women covered.

Dr. Weitz:            It’s fascinating. So the dosage, if it’s below a certain amount of estrogen, that it’s allowed?

Dr. Shade:           Yeah, yeah. Some of these creams that have… I think everything’s below 2%. And there’s some creams out there have like four or 8%, and so those have gone past those laws, but all of ours are in the legal range for hormones in topicals.

Dr. Weitz:            Now, one of the interesting things is it’s common in the functional medicine world to feel that serum testing doesn’t really pick up transdermal estrogen. So it’s become common to use saliva testing with the idea that saliva testing is better at picking up transdermal hormones. But I spoke to Mark Newman of DUTCH Testing and he did some research. His research shows that the compounded transdermal estrogen products are just not well absorbed.  And the fact that people are not picking them up on serum is not because serum is not a good way to test for it, because they’re not really getting absorbed. So it’s interesting that I’ve heard you talk about these creams and how these products, it’s an issue with getting them absorbed. He found that the FDA approved patch had more consistent results upon testing. But maybe it’s just a case that these typical transdermal creams, compounded creams are just not well absorbed.

Dr. Shade:           Yeah. I mean, that’s really what it is. When you look at what a cream is, in fact, the best way to do it, and I have some pictures of this, is to look in the microscope. I have this little swanky microscope here for blood analysis. And you put a cream on there and you see all these chunks in there. You see the bubbles of the emulsion, and then you see these big crude chunks of all this hormone that’s never been dissolved in there. And that’s why they’re big on micronized because the smaller they grind it up, little bits of hormone dissolve into the cream off the edges of these little chunks.  But most of it is staying on the skin is these chunks. Now, what does go in gets into lymphatic circulation and shows up in the saliva and you can get a number there. Now, if you put ours, you put it under the microscope, it’s just totally transparent because the light microscope can’t pick up the emulsion and there’s no particles of hormone left. They’ve all been dissolved into the oil phase in the center of the emulsion droplets. And then when you put those on, they go all the way through and you can pick them up in the serum.

                                It’s just a little funny in the serum. When we do the uptake studies with women, it’ll go up, it’ll go down, it’ll go up, it’ll go down. If you want a real good one, you use me or a guy and you see estradiol go up and flatten out and then eventually come down. But women are pulling it into all these compartments. So what we found is the best thing for looking at is like a DUTCH or RINE is the predecessor to DUTCH, and you get that 24 hour and it’s like bringing together, integrating that whole 24 hour period and you see all the hormones in there.  Most importantly, people’s symptoms go away. And when we get to talking about hormone levels versus receptor levels, you see why we do use analytical tools, but we’re not relying on them totally like, well, you have to be at this level and that makes you okay, because every person is different where they feel good and what their dosages are to make them feel good. And so actually getting them to the right dosage isn’t all that hard. You want to measure them before.  And then when they’re feeling good, get an idea for what those levels are. But levels aren’t gospel, again, as we talk more about the integration of the hormone level and the receptor level.

Dr. Weitz:            On the other hand, it’d be nice to do a test to see how well a woman’s level go up when they use your product.

Dr. Shade:           If you’re looking at the androgen side, like the DHEA and the testosterone, just do serum. Boom. I mean, the DHEA just rockets up there. It goes super physiologic. But that’s fine with DHEA. DHEA has never really shown to have a bad upper side unless people start getting some acne. It’s amazing when you do this nanoparticle delivery, you’re bypassing the liver and there’s way less incidence.  The women who are hyper prone to acne might have it, but most women don’t have any hair growth, hair loss, or acne because you’re not putting this bolus of DHEA through the gut and into the liver and making all of these androgenic metabolites. And then if you’re doing a pharmacokinetic study and you’re watching the DHEA come up in the blood, you’ll watch the testosterone in lockstep with it come up. So you’ll be super physiologic in DHEA and testosterone will be up at the high end of the reference range.

Dr. Weitz:            That’s in women, right?

Dr. Shade:           In women, in women, yeah, because men don’t turn DHEA into testosterone. It’s like the forbidden fruit for us. I don’t know why that is, but it doesn’t happen. In fact, when you take ours, if you’re not supplementing testosterone by say injection, then your DHEA will go up and your testosterone will actually go down a little bit and then come back up because there’s so much signaling of the DHEA at the endogen receptors that you actually down regulate your testosterone production.  Now, if you’re doing injections, then DHEA will just ride up and you’ll have a real high DHEA level. But then back to the women, you’re going to figure out, do you want a half dose, full dose and just figure out where they feel best. If you get them a little too high, they get a little bit aggressive, and you just bring that down. So again, you’re working with their symptom load. So that you can watch serum. When you’re working with progesterone and estradiol, you can see it in serum, you can work serum, but it’s a little bit better in urine.

Dr. Weitz:            You brought up your DHEA product, and I was surprised to see the dosage that you have in the DHEA. Because the interesting thing about the Quicksilver products is one criticism sometimes people will make is, oh, the dosage is so low. And the answer is, well, because of the delivery system, it’s better absorbed, and that dosage will be effective. So I was surprised. Normally, when I recommend DHEA for women, we’re typically talking about 10 milligrams, and you have 100 milligrams in your product.

Dr. Shade:           And why do we do 10 milligrams? Because people get symptomatic above that. 25 and they’re getting acne, they’re getting hair growth, but it’s not really driving their testosterone up. Maybe they go from 10 to 25, like ooh, and their DHEA is running at 200. But really you want it smoking, DHEA real high. DHEA is a major metabolic thing. It’s fantastic for the brain. It’s great for libido. And so having that up in the 600 level and the testosterone in a 60 to 100, depending upon what your dosage is, people just do freaking great. They feel fantastic.

Dr. Weitz:            So the benefits of DHEA, in your opinion, the main benefits are what?

Dr. Shade:           Cardiometabolic, really strong there. So all these women that are doing weight loss and stuff, the cardiometabolic aspect is really good. Brain, it’s super good. It’s a good mitochondrial benefit. And it’s real strong on the androgen receptors alone and the testosterone that it makes. In fact, DHEA is interesting. It’ll get androgen and estrogen receptors.

Dr. Weitz:            It’s interesting. It seems like 10, 15, 20 years ago, DHEA was being touted as one of the main longevity products. And the first study that reversed epigenetic aging, the Fahy study, that included DHEA. But lately people have forgotten about it and nobody’s really sure if it really does much. I’m wondering maybe if we’re not using enough dosage.

Dr. Shade:           Not doing enough. Those low dosages just don’t move the needle. I mean, my friend Lauren Bramley is this great hormone doctor, and she talks about the personality of hormones. And she talks about DHEA dominant people. I’m a DHEA dominant people. I would run four to 500 when I was younger, just all the time, just smoking high. And those people are hyper intelligent, and they go and they do stuff. They’re action oriented. They’re funny. They’re handsome. Wait, am I just talking about myself?  They tend to be intelligent, witty, and fun and inventive people. And that’s not 100 to 200. That’s 400, 500. You’re not going to get people running at those levels with these little doses. I mean, because you see people who have really low DHEA and it’s like 40, 50, 60, and I cry when I see that. You give your 10 milligram pill and maybe they’re at 150, but they’re not going to run where we are. And that’s really I think where the game changers are. And I would like to do an epigenetic study, get the true diagnostic stuff out again, and just have women on our whole hormone system.  I mean, don’t even leave it at just DHEA. All of it at once. I swear that’ll go backward or slow the rate of aging because you get into menopause, those hormones drop off. Your age just accelerates.

Dr. Weitz:            To go back to estrogen, in terms of estradiol, estriol, some of the data seems to indicate that most of the action really comes with estradiol.

Dr. Shade:           Well, I would say no. Totally it depends what action you’re looking for.

Dr. Weitz:            Well, I know it’s common to be combined estradiol with estriol.

Dr. Shade:           With the biest, and I’ll tell you why.

Dr. Weitz:            With the biest, right?

Dr. Shade:           I think it was just never conveyed correctly how this all works, because it’s like, oh yeah, for brain, for cardiovascular, for bone, estradiol is what moves the needle. Estriol doesn’t really do anything. But for UTIs, for vaginal atrophy, pelvic floor strength, estriol does the same as estradiol. Now, why is all this? There’s two estrogen receptors, estrogen receptor alpha and estrogen receptor beta. Estrogen receptor alpha has estradiol is really strong on and estradiol does nothing on.  And that’s the one that rules brain, cardiovascular, and bone growth, and a couple of other things. It’s also the one with the breast tissue that is more proliferative or more prone to being proliferative. So it’s the one we worry about if we have gene SNPs that predispose us to breast cancer, we have a family history. If we all have these markers of it, then we’re worried about estrogen receptor alpha and estradiol’s effect with it. Now, the other one is estrogen receptor beta. Estrogen receptor beta is all through the urinary tract, the vaginal tract, the whole lower 48.

                                And it responds really well to estriol and estradiol. The first time I was introduced to it, this woman, Mary Cohen, who treats all these breast cancer cases, was like, oh, you’ve got to have estriol alone and not compounded so we can really lay on it. And all these women who are breast cancer survivors, I can lay on that and they’ll get all the benefits because it’s that incontinence, UTIs, and vaginal atrophy is vaginal dryness, it’s thinning of the vaginal walls, it’s thinning of the tissue and the vulva, and it’s just the aging of that whole area.  And they can lay on estriol. And estriol has no effect on estrogen receptor alpha. And in fact, estrogen receptor beta has some counter effects to alpha in being anti-proliferative. So the two actually balance each other out. And in the body, you make estriol in your liver from estradiol and you pee it out, and that’s how it’s hitting all those receptors. And so estriol has a great application in the whole pelvic floor dynamic. And in our system, we advise applying it vulval. And the women are like, oh my God.

                                It’s like reversing the age, reversing vaginological age. The tissues change vastly. And that’s all the tissues down there change and they just go back in age, and all the women who are doing it just freaking love it. Now, you still need estradiol or you get… Perimenopausal, we have you start estriol, and then start bringing in estradiol as you go menopausal. Because when you go to hot flashes, you need the estradiol. And again, long-term, bone, cardio, brain, you need estradiol.  But you can just get the estradiol up high enough where you’re not flashing. If you’re in serum, you want to get north of 30, in the 40 to 50 range. I know a lot of people like to keep it up with pellets and stuff 80 and 100, but I’d like to just keep that right where you need it to be and really lean on the estriol. So there’s definitely a place for both of them.

Dr. Weitz:            I know that rhubarb extract that Metagenics came out with a number of years ago that hits the beta receptor seems to have some effectiveness against hot flashes.

Dr. Shade:           Okay. That’ll be interesting. I’ll look that up.

Dr. Weitz:            That’s their Estrovera product.

Dr. Shade:           Okay, I’ll check that out. Now, look at other things that work on the hormone system. You look at the really bad things like plasticizers. All the endocrine disrupting chemicals that cause cancer, they affect estrogen receptor alpha. Then we’re worried about anything that’s a phytoestrogen. We think, oh my God, oh my God, we’re going to get cancer. But most of those things, the soy extracts, ginseng activates or… Well, ginseng increases activity of estrogen receptor beta, and all these others that are phytoestrogens act on estrogen receptor beta.  So we have to look at this. We have to throw away our fear. We got to throw away all this stuff from the Women’s Health Initiative, which was absolutely designed and interpreted wrong. What they thought was estrogen leads to an increase in all-cause mortality, it actually led to a decrease in all-cause mortality. And any person who had cancer who had estrogen before had a higher survival rate and had lower cancer rates overall. And so we got to get away from all that fear.  We still got to respect it with respect to breast tissue and uterine tissue. We got to get away from the fear and know the beta versus alpha story.

Dr. Weitz:            And you still got to avoid synthetic progestins.

Dr. Shade:           Oh, yeah, yeah.

Dr. Weitz:            And oral estrogen.

Dr. Shade:           The whole antithesis to the estradiol effect of proliferation, well, part of it is from estrogen receptor beta, but a big wad of that is from progesterone, which is antiproliferative. And so you can’t use synthetic progestins because they don’t do that at all. Now, let’s first define something, synthetic hormones versus bioidentical hormones. Absolutely bullshit statement. All bioidentical hormones are synthetic.  This whole yam derived, like you go and you get four billion yams and you’re somehow about to get some estradiol out there. There’s no god-damn estradiol in a yam. All right? This stuff called [inaudible 00:20:36] it’s a precursor to making hormones. And so all hormones start with maybe a naturally derived precursor, and then they’re synthetically created into either a bioidentical or a non-bioidentical. And so this is where we trip ourselves up with length.

Dr. Weitz:            So instead of saying synthetic versus bioidentical, we’re talking bioidentical versus non-bioidentical.

Dr. Shade:           Bingo!

Dr. Weitz:            Like conjugated equine estrogen.

Dr. Shade:           Oh, yeah, yeah. I mean, that’s one of the big ones. I mean, Premarin had some bioidentical estradiol in there, and then they had all of these equinones or something, equines. They’re horse equilines. I forget the name, but they’re horse hormones. And you don’t even have enzymes to break them down. They’re finding these horse hormones in women years after taking Premarin.  I mean, Premarin did some good things, but there was a good Stanford study where all the cognitive effects of estradiol only from bioidentical, not from Premarin. And then you get into even worse things like the diethylstilbestrol, which is a non-identical estrogen, the non-bioidentical progesterones. And why would they make those? Because you can’t patent the compounds of the hormones because they’re already naturally occurring.  So they make non-natural hormones that affect the receptors and sometimes affect the receptors more powerfully than the native hormones, but they don’t affect all the different things that the native hormones do because the native hormones will trigger this, but they’ll also bring in help from these other pathways that make it a whole balanced thing. And that was what happened with the non-bioidenticals. They nail this, but they don’t hit any of these other targets and you get this imbalanced thing that was more likely to lead you towards cancer.

Dr. Weitz:            Now, my friend Dr. Felice Gersh, she usually argues against estriol because she says number one, estriol is basically the hormone of pregnancy. It’s not something naturally occurring in decently high levels throughout a woman’s life. And number two, the real bang for the buck is with estradiol, not with estriol.

Dr. Shade:           I don’t know why she says that. I know Felice is the only one with this story out there. And then you see our story and it’s like, I mean, yeah, I could just load you with estrogen and I’ll hit all the receptors, but is that really what we want to do? And when you look at how it works, estradiol goes to the liver, turns to estriol. You pee it out. All the receptors along the urinary tract are beta receptors, and it goes in there and hits them. And then what? Think you’re off in the cave. You’re growing up in the wild, that pee’s splashing into the vaginal tissues.

                                And it’s like maybe you shouldn’t wipe so much. Maybe you’re getting some of that in there because that’s estrogen receptor beta in there too. And so there’s an obvious use of estriol because it works on beta, because it has some of these antiproliferative effects. You don’t have tons of circulating, but you have a lot going out through the urine. So I think that’s the way that it was designed in nature, and I just don’t think she’s right there. And then there’s this question about competition at the receptors.  But if you have a high affinity for a receptor like the alpha, then diol is going to get in there and out-compete triol in a second. Triol’s never going to get in there and get in the way of the diol when it’s a competition for a receptor there.

Dr. Weitz:            You were talking about environmental estrogens, and I always wonder if let’s say you’re working with a guy and he has high levels of estrogen, or maybe he’s got low levels of free testosterone. You’re trying to see if maybe environmental estrogens are playing a role. Which form of estrogen would you measure? Or is it possible to measure? The options are to measure estrone, estradiol, or estriol.

Dr. Shade:           It seems to be all diol for the guys. That’s the driver.

Dr. Weitz:            Now, what about for the environmental estrogens? Which one would those be picked up as? Or can they be measured at all?

Dr. Shade:           Oh, they won’t be picked up as estradiol. They just fit in the estradiol receptors. If you know, you’re looking for these five chemicals and you have a test for them, problem is we don’t have a lot of tests for all these things. It’s the academic places where they look at all 203 or however many chemical.

Dr. Weitz:            We usually do a urine test for environmental toxins.

Dr. Shade:           And that’s going to get some of them, but it’s not going to get all of them.

Dr. Weitz:            Right. Yeah.

Dr. Shade:           One thing to do, look at testosterone, look at estrogen. You’re looking at ratios between them with a test estrogen ratio of hopefully like 20 to 30. When you’re down at 10 to one, and that’s with the units as they’re reported, if you’re like at 10 to one, then you’re high estrogen and you’re going to be a little heavy on the mammary glands. And then 20 to 30, you should be very lean. But if you aren’t and you’re showing this estrogenicity, then that’s likely coming from some environmental estrogen.  And then as we talked about before, I think the thing that we’re missing totally… I have all these friends, these guys in their 60s, maybe early 70s, and I look at them and they’re really sarcopenic. They’re losing a lot of muscle mass. Skin’s hanging down. They’re slow. Definitely have no libido left. Some may. And I’m like, you need testosterone, buddy. There’s just no if, ands or buts about it. And they’re like, my testosterone level’s high. It’s 600, 700. When I was young and just running off my own testosterone, I was only 500, but I had low estrogen.

                                I had almost no binding globulin, and I had a lot of DHEA, and I was plenty androgenic. So those levels are high enough to do that. But here is what androgenicity is or estrogenicity is, it is the level of the hormone multiplied by the density of the receptors for the hormone. The hormone doesn’t go right in and do things. Like in a woman, it doesn’t turn the libido switch. It hits the androgen receptor. The androgen receptor then goes into the nucleus and codes for all the genes to be turned up that are responsive to the androgen receptor.

                                And then there’s these downstream things that happen. So you look at a woman and you’re going to dose her up with testosterone, try to restore her libido. Does that happen the day after you get the testosterone? No. That’s like seven to 10 days later. There’s this lag there. So the receptors are what are causing a cascade of things to make that happen. Now, you have a testosterone of 600, 700, and you’re young and you have… I’m just going to make up an arbitrary one to 10 scale.  I’ve got a eight of receptor density. So the testosterone could go in there, activate that, go to another one, activate that, go to another one, activate that. There’s a lot of targets to hit. But now you’re 65 years old and your receptor density is down to a three, and then the testosterone is just floating around looking for something to do. And it’s not activating anything and therefore you’re non-androgenic. And finally, it hits one. That’s the thing that we’re missing.  So there’s two things bringing down receptor activity. One is the absolute density, which is known to go down with time, and the other one is poisoning of the receptors by endocrine disrupting compounds.

Dr. Weitz:            Is there such a thing as receptor sensitivity? Can a receptor work better or worse?

Dr. Shade:           Yeah. We don’t have that one totally dialed in, and that might be like there’s some chemical stuck to the receptor and it doesn’t work as well. But then there’s when the chemical goes all the way inside and blocks the hormones from getting in there. So there’s a receptor, but it’s blocked and it won’t work. And we don’t know really if there’s a receptor, it’s working at 50% versus 100%. I imagine there is. But what we do know is you have less receptors.

Dr. Weitz:            Is there any way to measure…

Dr. Shade:           When you take all the testosterone out of the body, the density of the receptors goes down. Nobody has that test now. I mean, there’s ways to…

Dr. Weitz:            There’s no way to measure it?

Dr. Shade:           It’s just in academic labs right now. So we know those go down with time. And then we know they also get poisoned by other chemicals. So you can go in and detoxify them. Back to detox again. Any subject we bring in, we can go back to detox. And so you do PushCatch Liver Detox. Maybe add a little more DIMs and glutathione and roll them on that for a while and you’re going to move these plastics and pesticides and herbicides or atrazine, get those things out. But then what if you all clean but you’re only left with a couple of receptors?  You’re at like a two or three? How do you get those up? And turns out, adaptogens. There’s great data on adaptogens increasing density of the hormone receptors. Now, I always like to say, let’s bring ourselves back. I’m an emperor, emperor so back in China 2,000 years ago, and I’m getting old and they want to keep me virile and keep me up at heart and keep my muscle mass on and have me be an emperor of the world. And they don’t have injectable testosterone cypionate.

                                And so what do they do? So you’re eating testicle and tiger penis and deer penis. You’re eating, because those all have testosterone in them. And then you’re eating the deer antler tips, which have growth hormone or IGF-I at least in them, which are growth hormone stimulator. So you’re bringing up hormones that way, and then they’re giving you shit tons of the best ginseng. And those ginsenosides have the same steroid backbone as the hormones. So they work in with the receptors in some way.  And astragalus, ashwagandha with [inaudible 00:31:27] I forget the name of the plant, but all those, it’s beautiful. They all have a steroid hormone backbone and they go in and they massage those receptors and make them work better apparently. That one, we don’t know quite how that works, but they definitely get more density, more replication of the receptors, and then you get more hormone activity.

Dr. Weitz:            I saw some webinar you did, and you were talking about some of the heavy metals, and you mentioned how nickel was one of the heavy metals sets. Seems to be a big player in some of this estrogenic stuff and that kind of interest.

Dr. Shade:           At low levels they’re blocking receptor activity, and at high levels they’re activating receptor activity. So yeah, nickel is a metalloestrogen. Cadmium is a metalloestrogen. It screws the receptors bad, because we know cadmium is probably the biggest cancer causer in testicles and ovarian. It’s probably mostly ovarian, but it could be cervical cancer as well.

Dr. Weitz:            I think nickel is part of steel, right? And here we are avoiding bisphenol A, so we’re using steel water bottles and we may be getting nickel toxicity.

Dr. Shade:           Yeah, yeah. I remember a couple of years ago, I had my girlfriend, I was like… Polydipsia. She was drinking water all day. These people in Colorado are water junkies. And I’m like, screw that stainless, man. This is no good if you’re just after it all the time.

Dr. Weitz:            Does the nickel come out of stainless steel?

Dr. Shade:           And she’s been on glass for three years.

Dr. Weitz:            Does nickel come out of stainless steel?

Dr. Shade:           A little bit of it does.

Dr. Weitz:            Yeah.

Dr. Shade:           Not a ton, but a little’s coming out. The more you put acids in there, the more of it comes out.

Dr. Weitz:            A bummer is every time I try to use one of these glass water bottles and I take it to the gym, I end up breaking it.

Dr. Shade:           Oh yeah, I know. They got ones that are covered in rubber and stuff.

Dr. Weitz:            I know. They still break easy.

Dr. Shade:           Maybe at the gym you bring your steel. Just glass for the rest of your day.

Dr. Weitz:            So we have no way to tell if we were having fewer hormone receptors.

Dr. Shade:           Nor if they’re poisoned.

Dr. Weitz:            Right.

Dr. Shade:           Except by saying your levels are high and you got jack. So let’s bring those up and let’s jam your levels up too. Some of these guys, I would put their test levels up to 1,200 to 1,400 and just saturate them with high quality adaptogens.

Dr. Weitz:            What are your favorite adaptogens for that purpose?

Dr. Shade:           I think ginseng is probably my fave, but then I always love blending all these other things in with them.

Dr. Weitz:            I think maca is a pretty powerful one.

Dr. Shade:           Yeah, maca is a great one. We don’t understand those compounds as well, but they have great cultural use. You’ve got scientific use, so you’ve got cultural use, and so you could do both. We put the maca in that DHEA. But for the guys, ginseng, astragalus, He Shou Wu, ashwagandha, those are my favorite. But for male regeneration, ginseng is at the top. In Chinese medicine, if you’re young, they’d give you astragalus and they’d say that would build your wei chi or nai chi wei, the outside energy.  Make you more resistant to disease, make you stronger on the outside, because you’re strong on the inside, young. When you get old, you get weak on the inside and the outside, so they give you ginseng to bring you up from the inside and then they’ll give you astragalus for the shield on the outside.

Dr. Weitz:            So when it comes to female hormones, the progesterone you have available is also a topical?

Dr. Shade:           Yeah, it’s a topical.

Dr. Weitz:            So it’s pretty common to use oral progesterone in functional medicine world, because it seems like the oral is more effective than the topical.

Dr. Shade:           Well, it’s more effective than the topicals that are the creams with the micronized stuff in there.

Dr. Weitz:            I see.

Dr. Shade:           We’re able to get everything done that we need with these topicals. And so you look at an oral, oral base dose, there’s 100 milligrams. People will have maybe 200 milligrams, 9% absorption. So you’re only getting nine milligrams from 100 milligram.

Dr. Weitz:            Oh, interesting.

Dr. Shade:           From the topicals, we’re using mostly 12 to 16 milligrams a day. And we’re getting similar results even probably better when it comes to sleep. And similar when it comes to mood and anxiety, these are the things that progesterone does. It works on the GABA receptors, makes you calm, makes you happy, not irritable. It makes you sleep really well.  So we’re able to get that added 12 to 16. Occasionally, you need 20 milligrams. It works well. The only thing we’re not able to measure is endometrial thickness, and that was the measure that was made around the oral to prove that 100 milligrams is where you get endometrial thickness control, the thinning of the endometrial.

Dr. Weitz:            Right.

Dr. Shade:           Because that’s the thing, estrogen…

Dr. Weitz:            Unopposed estrogen.

Dr. Shade:           And progesterone’s clearing it back off for you. We haven’t been able to do those measurements yet. We’re seeing if somebody can do the ultrasound work on that.

Dr. Weitz:            Okay, that’s interesting. So one of your webinars I was watching, you were talking about sirtuins. I guess there’s a big controversy now about sirtuins with David Sinclair.

Dr. Shade:           …guy because he’s freaking taking away our use of NMN.

Dr. Weitz:            Yes, I know.

Dr. Shade:           Which part of the controversy?

Dr. Weitz:            Well, I guess there’s a controversy about the resveratrol.

Dr. Shade:           All right, so here’s how that all works. If you’re a sirtuin, you’ve got two openings here. For a ligand to come in. This is something that’s going to bond in to the protein and activate it. And on this side you’ve got the quintessential one, the one for NAD, NAD+, and that activates it. Then there’s another receptor that certain compounds called sirtuin-activating compounds can come in and bring it up to even higher level to super activate it. But if you don’t have any…  So if you go in with just resveratrol and you don’t have high NAD levels and you try to run it with a high resveratrol level, you’ll actually succeed in doing this by drawing NAD from other pools in the cell over to the sirtuin. Now, that can pull NAD away from PARPs that are doing gene repair, can pull it away from CD8s that are doing other types of cellular repair, and it can pull it away, most importantly, from the electron transport chain where it’s taking electrons from the citric acid cycle and bringing them over to the electron transport chain.

                                So even though sirtuin activation is supposed to give you heightened mitochondrial function and mitochondrial density, if you don’t have the NAD to support the resveratrol going in there, it’ll actually cause mitochondrial dysfunction. In fact, I had a guy in here I was interviewing yesterday that was saying, I could never reproduce what he was talking about back in grad school. And I told him this thing about NADs. He’s like, that’s why. I did a sirtuin activation study on a couple of people that were younger.  And we didn’t measure their NAD levels, but I was able to get great activation of sirtuins with a combination of resveratrol, pterostilbene, and maybe curcumin and quercetin. So we definitely did it. But that’s what I tell people, you got to watch out. When you’re low NAD and low ATP like in a weak person and you try to drive it with resveratrol, you’re going to drive them over the cliff. You bring up NAD levels first, you get that strength, and then you put in the resveratrol, and then you get the benefits.  And that’s why in those early studies it was like half of the cohort is doing great, half of the cohort is getting screwed up. They just cut all those things and stopped them.

Dr. Weitz:            What do you think about…

Dr. Shade:           And that’s when Sinclair was trying to make a drug out of resveratrol. Now he’s trying to make a drug out of NMN, and his company is the one who drove the FDA to try to take NMN away from the supplement companies. And that was a pretty shitty move.

Dr. Weitz:            But it seems like it’s still available?

Dr. Shade:           Yeah, it’s still available, but Facebook and Amazon won’t let us sell it. One of our payment processors, Shopify, won’t let us sell it. It’s like, guys, this is not a law yet. This is what they said they wanted to do and it’s all under review and you’re just acting as the enforcement arm for the FDA.

Dr. Weitz:            It’s like the same thing with NHC, right?

Dr. Shade:           Yeah, no, it was the same thing and it got all shunned by all the retailers and Facebook will stop you for having it. They’ll stop you advertising. But then NHC was given an exception. So we think that’s what’s going to happen with NMN. It hasn’t happened yet. There’s a lot of us throwing money into a common fund to sue those bastards.

Dr. Weitz:            Interesting. What do you think about NR versus NMN?

Dr. Shade:           They’re both really good. They’re a little bit different. They’re very similar. NR becomes NMN, which becomes NAD. Then when you’re trying to traffic the stuff cell to cell to move around your stores of NAD potential, you’re trafficking NR and NMN. They’re both good.  We’ve been working with NMN, worked through the intellectual property stuff around ChromaDex. ChromaDex had a “patent.” I’m doing big air quotes on the patent because it was a pile of freaking garbage. And finally, Elysium took him to task and went to court and the judge just shut it down and said, “This is a garbage patent.”

Dr. Weitz:            Oh, really? Why was it a garbage patent?

Dr. Shade:           It was garbage because, one, you’re trying to patent a natural molecule, which you can’t do. It should have been rejected just because of that. And then to get it in there, they started saying, well, the claim is NR in Ringer saline for injection, in this saline for injection, in coconut butter for doing a suppository, in a tablet for this, in a thing with this. And actually the junior patent attorney wrote this because juniors always write these things when they come out of university. He just came out of university.  And I know this all. My patent attorney is one of my best friends, and he wrote one of my first patents as a junior guy. And now he’s super experienced and he’s like, look at what they did. And instead of NR with this or with this or with this or with this, they put and. So really to violate the patent, you would’ve had to compound the NR with anything else that made it into eyedrops or suppositories or tablets or capsules or IV all together before you violated it. So it was just freaking garbage.   And in the supplement world, everybody’s afraid of a patent. They never have their patent attorneys read them and see whether there’s anything substantial there. So ChromaDex got away with having a monopoly on NR for years, and they sold it for a bajillion tons. And now Chinese synthetic labs will sell it to you for pretty cheap.

Dr. Weitz:            Oh, interesting.

Dr. Shade:           But NR, I’d be doing NR, but NR is less stable, and so it’s harder to work with in liposomal formulations. We’re going to get around that soon. If anybody’s selling you liposomal NR, it’s probably mostly broken down.

Dr. Weitz:            There’s so many companies out there claiming their products are liposomal.

Dr. Shade:           Oh my god, liposomes have exploded. Some is just absolute lie. It’s just like stuffing lecithin and some stuff in a capsule.

Dr. Weitz:            Well, that’s what a lot of it is, right?

Dr. Shade:           Oh yeah, it’s just freaking bullshit. Then, oh yeah, your stomach makes the liposomes. I have a million dollars worth of equipment over there that makes a liposome. So you’re telling me the stomach does the same thing they do? Eh-eh. And then others are just low grade. They’re getting cheap lecithin. They blend it up. You’ve got this milkshake looking stuff.

Dr. Weitz:            One of the issues has to do with taste. My wife has taken all this liquid stuff that comes in these little packets and it tastes good. She doesn’t like the taste of your products.

Dr. Shade:           They’re probably using symbiotic or something where it’s low grade with a bunch of syrups and flavorings. One of them had almond butter in it, so it absolutely could not have been a liposome. It was just some schmutzy blend up thing. And that’s where we get some is shit for our taste, because we taste like the compounds that are in it. I started in autism and Lyme and these guys are allergic to everything, so you couldn’t put all these synthetic flavors in.  Now I’m starting to juice them up a little bit and make them taste a little bit better. But if you want to buy elite supplements to get super good effect, just take it in there. Let that flavor get in there. It’s like the Vipak, the post digestive taste effect. I think that’s the right term for an Ayurveda, but taste is big in Chinese medicine and Ayurveda. It affects you, and it signals the body what you’re going to do. [Crosstalk 00:46:18]

Dr. Weitz:            Like the bitter herbs are so powerful because they’re affecting those taste receptors. Birth control. Most people don’t realize how potentially damaging birth control is. Maybe you can talk about how that affects hormone.

Dr. Shade:           I’m not great on the subject. I mean, I know how very damaging it is. It’s screwing up receptor density. It’s screwing up signaling, and it takes years and years to wean yourself or repair from the effects of the…

Dr. Weitz:            Right, to get your normal hormone levels to come back.

Dr. Shade:           To get all your hormones back. All this signaling has turned off all of your normal stuff. It was funny, my son was asking me yesterday about… Because he’s like 17 and he’s this wicked bodybuilder. And he said, “Oh, I had this great December. I grew all these pounds.” And I said, “You’re not taking steroids, are you?” He goes, “Well, I’ve been sneaking your testosterone, dad.” He was just kidding, because he was even scared of that. It’s one thing to be taking steroids and get deca dick and freaking lose everything, but he thought like…

Dr. Weitz:            Deca dick.

Dr. Shade:           Deca dick. It’s something called deca-durabolin. It makes you all anabolic in your ooh. But he thought if you go on test, you can never go off it. I’m like, no, you can go on and off. Just when you’re on it, your testicles going to atrophy and they’re going to come back down, but you could turn it all back on. And sometimes it’s easy to turn that stuff back on. Like test you could turn that back on. It doesn’t take long. But there’s something about the birth control that turns it off for a much longer period of time.  And this isn’t my area of expertise. I usually let Carol Peterson talk about that. So I don’t know exactly why that is, but it shuts it down for a long period of time. And you almost have to bring on bioidentical hormones first to reset the signaling and the way the cells respond, and then you got to nurture the rest of the system back up. I mean, some girls go off of it and everything’s fine. Other girls don’t.

Dr. Weitz:            It’s interesting that so many of these environmental endocrine disrupting substances all seem to be estrogenic versus androgenic.

Dr. Shade:           Yeah, versus androgenic.

Dr. Weitz:            Why do you think that is?

Dr. Shade:           I’d love to have a really savvy, oh, that’s because of this. I don’t have a savvy answer for that. I don’t know. Maybe we’re not even looking at it. The early endocrine disrupting stuff, it was making teenage boys fat and have gynecomastia. And so they would call them obesogens and they said, “Well, this must be all estrogenic.” And they did have estrogen receptor activity. But you know what? We missed all that.  Then later these papers are coming out, endocrine disrupting chemicals and cardiovascular disease. What they do is they inactivate the sirtuins, so they block sirtuin activity. And that is cardiometabolic wellness. So they’re turning on estrogen reception while they’re blocking sirtuin activities. So they have this dual sexual dimorphism problem and a cardiometabolic poisoning problem.

Dr. Weitz:            Interesting. That’s another thing we can’t measure, right, sirtuins?

Dr. Shade:           Well, I mean, you can’t go out to Labcorp and do it. We did one where we had to… It’s one of these research things. We had to isolate the peripheral white blood cells, put them on dry ice and send them to a lab that could do the assay for nuclear and cytosolic sirtuin activation. So you get total sirtuin levels and activated sirtuin levels.  We are doing this with a capsule-based liposome, like a real capsule-based, where it turns into nanoparticles in the GI. And it took about two hours. They activated it and it lasted about 24 hours. And so I’d like to repeat that with our AMPK charge and some of the NAD platinum, and I’m sure we’ll get similar results. So once you hit it, it does seem to stay activated for a while.

Dr. Weitz:            So the best way to get rid of these estrogenic substances, like these heavy metals like cadmium and nickel, are with your PushCatch system?

Dr. Shade:           Yeah, yeah. You should really upgrade to the advanced PushCatch because then you got liver sauce, kidney care, phosphatidylcholine is really good for helping with this process, and glutathione in there. A lot of these things are conjugated to glutathione, and then you have the binders.   So that’s general organic endocrine disruptors. You might throw a little bit more DIM in if you want. That could help. But then if you’ve got metals, then you got to go to the pro version, Qube 2.0, and that’ll bring in the IMD Metal Binder and EDTA. And that’s a nine week, much more intensive protocol.

Dr. Weitz:            Isn’t the IMD in Ultra Binder anyway?

Dr. Shade:           Yeah, but it’s not in there real high. You got like a half a scoop in a teaspoon. When I’m titrating up in a metal detox protocol, I’ll have you get up to three scoops twice a day on top of the Ultra Binder.

Dr. Weitz:            Oh, okay. Interesting. I think those are the main things that I had to talk about. Anything else you want to mention?

Dr. Shade:           I’ll just mentioned that for all the practitioners, we have an online learning management system to understand the hormones and our hormone system. And you just have to become a Quicksilver Scientific practitioner, which means you just go get an account with us online. It doesn’t matter if you’re buying from Fullscript or some distributor. You need an account with us to get all the education. We have 30 to 40 different webinars in there.  We have a free learning management system around detoxification. And then you pay a little bit like 200 bucks for the one on hormones and it also comes with a sample box of all our different hormones. So getting in, getting educated. A lot of people want to get into treating hormones. Everybody’s afraid of it. You don’t need to be afraid. You just have to be educated.

Dr. Weitz:            Yeah, it is a little scary if your license doesn’t include prescribing.

Dr. Shade:           Yeah, yeah, exactly. And so here you learn all the ins and outs of it.

Dr. Weitz:            That’s great.

Dr. Shade:           If you’re just certified, those are licensed only products unless you do the learning. If you go through that course and finish it, then we graduate you to a licensed practitioner and then you can buy those.

Dr. Weitz:            So practitioners can go to quicksilverscientific.com.

Dr. Shade:           Yep, that’s it, and go apply for an account.

Dr. Weitz:            That’s great. Thank you so much, Chris.

Dr. Shade:           Thank you, Ben.

 


 

Dr. Weitz:            Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five-star rating and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation.  Some of the areas I specialize in include helping patients with specific health issues like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen, and to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way. Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111 and we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.

 

Dr. Nalini Chilkov discusses An Integrative Approach to Cancer at the Functional Medicine Discussion Group meeting on March 28, 2024 with moderator Dr. Ben Weitz.  

[If you enjoy this podcast, please give us a rating and review on Apple Podcasts, so more people will find The Rational Wellness Podcast. Also check out the video version on my WeitzChiro YouTube page.] 

 

Podcast Highlights

4:08  The relationship between cancer and obesity and glycemic control is huge.  Patients who are obese, have hyperglycemia, and hyperinsulinemia have a 40% increased chance of being diagnosed with cancer and have a 40% increased chance of a cancer recurrence.  Both insulin and insulin-like growth factor that are actually proliferative signals.  And tumor cells have more glucose, more insulin-like growth factor receptors, and more insulin receptors than normal cells.

7:34  The United States is a sugar nation and diabetes and obesity continue to rise here.  Obesity accounts for 14% of cancer diagnoses in men and 20% in women, and its higher in women due to the estrogenic effect of fat.  Some cancers are more directly linked with these signally pathways, including GI cancers like colon, gastric, gall bladder, and pancreatic cancer, liver cancer, endocrine cancers, Hodgkin’s Lymphoma, Multiple Myeloma, and renal cancer. There are biomarkers that we can measure to evaluate the cancer terrain in the tumor microenvironment. By identifying these signally patterns, including glycemic control, inflammation, and obesity and making changes to their diet and lifestyle, we can help patients to have better outcomes and have less chance of recurrence. 

 



Dr. Nalini Chilkov is the founder of the American Institute of Integrative Oncology Research and Education and the creator of the The OutSmart ® Cancer System.  It is her mission to change the face of cancer care so that every patient has a plan for their health and not just a plan for their disease at every phase of the cancer journey. She is committed to training front line clinicians worldwide to become skilled and confident in serving the health needs of patients whose lives have been touched by cancer by utilizing her OutSmart Cancer® System. She is the author of the best seller, 32 Ways to Outsmart Cancer_How to Create A Body Where Cancer Cannot Thrive and is recognized as an authority and pioneer in the fields of Integrative Cancer Care, Cancer Prevention and Immune Enhancement. Dr. Chilkov has lectured worldwide and at the Schools of Medicine at UCLA and UC Irvine and is a frequent expert resource to the media.  Her websites are Nalinichilkov.com and the American Institute of Integrative Oncology.

Dr. Ben Weitz is available for Functional Nutrition consultations specializing in Functional Gastrointestinal Disorders like IBS/SIBO and Reflux and also Cardiometabolic Risk Factors like elevated lipids, high blood sugar, and high blood pressure.  Dr. Weitz has also successfully helped many patients with managing their weight and improving their athletic performance, as well as sports chiropractic work by calling his Santa Monica office 310-395-3111. Dr. Weitz is also available for video or phone consultations.

 



 

Podcast Transcript

Dr. Weitz:          Hey, this is Dr. Ben Weitz, host of the Rational Wellness Podcast. I talk to the leading health and nutrition experts and researchers in the field to bring you the latest in cutting edge health information. Subscribe to the Rational Wellness Podcast for weekly updates. And to learn more, check out my website, Drweitz.com. Thanks for joining me, and let’s jump into the podcast.

                        I want to introduce our speaker, Dr. Nalini Chilkov. She’s the founder of the American Institute of Integrative Oncology Research and Education, and she’s a creator of the OutSmart Cancer System. It’s her mission to change the phase of cancer care so that every patient has a plan for their health and not just a plan for their disease at every phase of the cancer journey. She’s committed to training frontline clinicians worldwide to be skilled and confident in serving the health needs of patients whose lives have been touched by cancer by utilizing her OutSmart Cancer System. She’s the author of the bestseller, 32 Ways to OutSmart Cancer: How To Create A Body Where Cancer Cannot Thrive. And she’s recognized as an authority and pioneer in the field of integrative cancer care, cancer prevention, and immune enhancement. Dr. Chilkov has lectured worldwide and it’s a frequent expert resource to the media. Thank you, Dr. Chilkov.

Dr. Chilkov:        So, we’re going to be an intimate group, so I’m going to ask you to move to the center. I’m going to ask you to come so I can just look at one place and we can have eye contact and since it is a small group, we can be more interactive. So, while I’m lecturing you have a question, just raise your hand and I’ll be happy to answer it. Otherwise, I’ll also leave time at the end. So, we’re going to talk about cancer, and insulin, and obesity. And I particularly like to give this lecture to primary care clinicians because we have such an epidemic of metabolic syndrome, and obesity, and diabetes in our country. And this really causes a large group of patients to be at high risk. So, we’re going to talk about that and then some of the interventions that I use and some of the assessments that I use. And I think it’s really important in a primary care practice to be aware of this.

                        This is part of a online training that I have for primary care and frontline clinicians. So, if you get really inspired tonight, you can reach out. We’re happy to talk to you about my course. It’s self-paced. And then I also have a mentorship group for those people who want to have you review your cases and help you through them. And it’s a pretty engaged group. It’s a wonderful community that we have once a month online together. And also you can have a big discount by attending this. So, if you’d like that, you can just email us. I’ll give you my email address if you want to get the PDF of this lecture or you want more information about the course with the discount. And also, do you give people a PDF of the lecture?

Dr. Weitz:          What’s that?

Dr. Chilkov:       Do you give them a PDF copy?

Dr. Weitz:          I can.

Dr. Chilkov:       Yeah, so you can have the lecture slides. And I have this little handout that’s really nice to give to patients so that they can understand how to eat if they’re diagnosed with cancer. And so, it’s just like a checklist. It’s a one-page handout. If you’d like to have that for your practice, then you can have that, too.

Dr. Weitz:          All right, yeah, please give me your PDF, I’ll put it in my list.

Dr. Chilkov:       Well, I have one so we can send it to you.

Dr. Weitz:          Okay.

Dr. Chilkov:       We can just send it to you.

Dr. Weitz:          Okay, sounds food.

Dr. Chilkov:        All right. So, if you memorize this slide, you got the lecture. Okay. So, the relationship to cancer, obesity and glycemic control is huge. Patients who are obese, patients who have hyperglycemia and hyperinsulinemia have a 40% increased chance of being diagnosed with cancer and they have a 40% increased chance of having a recurrence. So, it’s a teaching moment for people. And people come into our practices at every stage of their cancer journey. So, wherever they come in, it’s a teaching moment as far as I’m concerned. So, if you look at these relationships, of course lifestyle is a contributor to all of these. But when you have insulin resistance and hyperinsulinemia, you have this driving force that has growth factors. And so, it’s insulin and insulin-like growth factor that are actually proliferative signals. And tumor cells have more glucose, more insulin-like growth factor receptors than an insulin receptors than normal cells. So, that’s why cancer is exquisitely sensitive to changes in blood sugar and insulin.

Dr. Weitz:          There’s one thing missing from the slide. Where’s Ozembic?

Dr. Chilkov:        That’s a whole other discussion, isn’t it? But it is interesting. It is interesting because when people have more normal body composition, less percentage body fat, more glycemic control, more normal insulin, more normal blood sugar, they don’t have the signaling going on. So, that population, that obese and diabetic population, is not only decreasing their risk of cardiovascular disease, which has been in the news, but they are also decreasing their risk of cancer that is driven by these pathways. Not all cancers. And some cancers are more explicitly sensitive to glucose. I have some slides on that for you. But at any rate, so you can measure fasting insulin and insulin-like growth factor one when you do labs on people. And then of course we know that people who are diabetic and obese also have more inflammation. And we also know that there’s a hormonal component, which I’m going to show you that as well.  So, this is essentially what we’re going to talk about. And it’s pretty daunting the amount of people in the world that are impacted by this. And so, that’s why I think it’s really important for primary care and frontline clinicians to be aware of this. And what’s true is that one in two adults with diabetes is diagnosed. So, these people are running around with higher risk, many comorbidities. And so, I think it’s really important for primary care clinicians to be aware of this. And these are just some statistics that are so really depressing. I want to read them to you. But if you look at the darker colors on this, the dark countries, that’s where the highest rates of diabetes are. So, welcome to America. All right.

                        So, this is the curve of the acceleration of diabetes in this country. United States is a sugar nation really. We teach kids to have a sweet tooth, really young. And so, it’s really a problem. So, what we’re going to talk about is first obesity being a major risk for cancer. And of course that goes along with diabetes. But not always. Not always. So, obesity is related to 14% of all cancer diagnoses in women in and… 14% in men and 20% in women. It’s higher in women because of the estrogenic effect of fat. So, that’s pretty daunting. And also, I just want to point out this book. Although it was published a long time ago, I recommend it because it has this really clear explanation of the physiology that we’re talking about. So, if you just want a really good reference to read in more in detail these signaling pathways, it’s just really well-written basically.  And so, if you look at, these are the cancers that are most linked to obesity. But you can see it’s a pretty wide range of cancers. It’s not just one category. So, you’ll see that there are GI cancers there. You’ll see that there are endocrine cancers there, liver cancer, and you can see Hodgkin’s lymphoma and renal cancers. So, it’s a wide range of cancers. So, obesity by virtue of changing the hormonal milieu, changing the inflammatory milieu, this is part of driving cancer. And one of the things we talk about in an integrative approach is oncologists are fascinating by the tumor, but they’re not fascinated by the biosystem that’s hosting cancer. And that’s what we need to be interested in. And so, we want to be interested in what we call the tumor microenvironment or the cancer terrain, which is the signaling environment that will either be proliferative or supportive of carcinogenesis, and proliferation, and progression of metastasis.

                        So, there are biomarkers that we can measure to evaluate that cancer terrain in that tumor microenvironment. And thereby, put a treatment plan together for the health side of the cancer equation. And that’s really what I teach. So, my mission, if you will, is not to train integrative or naturopathic oncologists, but it’s to train people like yourselves, how to monitor patients at every stage of the cancer journey and put together health plans, and identify these signaling patterns in their biosystem so that they also have better outcomes from their treatments, they have less chance of recurrence. And then we can restore their health and give them a biosystem that is not going to be supportive or hospitable to cancer development or recurrence. So, that’s the framework. And so, thinking about glycemic control, and inflammation, and obesity, and body composition is within that framework. Yes.

Speaker 3:         Is there a certain BMI, like is it BMI number 25 that presents this increased risk [inaudible 00:10:56]?

Dr. Chilkov:        So, the question is what about BMI? So, there’s no hard and fast statistics on that. I really think more about body composition. We know BMI is a waffley way too. But you could say 25. You could 25 is where there’s too much body fat. And then you get into because there’s more body fat and less muscle mass, then we get into all kinds of other metabolic issues. And think of the age demographic as well. So, the age demographic for cancer patients historically has been people over 50. Now we’re having an epidemic of younger people under 50 being diagnosed.

                        And in the press right now in the medical community go, “We don’t know why that’s happening.” But that’s a pretty lame comment because of course it’s environment, it’s body composition, it’s the endocrine disruptors in our environment, it’s stress, it’s sleep cycle, it’s all the things we know cause health or the lack thereof, make you vulnerable to multiple types of chronic illnesses. And cancer is a chronic illness. Cancer is not an urgent care. Cancer is not a short-term crisis. It’s a long term metabolic problem. It is a chronic illness and it has to be framed as such.

                        And if you look at it through that lens, you’ll address the whole biosystem and all the signaling, and the way that you are trained to practice already. If you keep looking through that lens, understanding what to pay attention to. So, these are some of the things we want to pay attention to. So, these are the cancers that are most associated with obesity. And so, you can see that they’re also diverse. It’s not kind of one category of cancers. But it is very interesting. Also, I think gastric cancer should really be on this list because gastric cancer is becoming more common, especially in younger people. And it is a cancer where error in fatty acid metabolism is part of what drives the cancer. And so, for example, sometimes we use statins off label for these types of cancers. And so, this in our country where obesity is such a problem is an issue. And should therefore be aware that you might want to be screening people more for cancer if they’re obese or have glycemic control issues.

                        So, I have a lot of slides. This is a longer lecture typically, so I’m not going to read all the slides to you. But if you want to get a copy of them and read the details, I think our time is better spent in dialogue than in me reading slides to you. So, obesity is a risk factor. And there’s other things that go along with that. If you have surgery and you’re obese, you have more complications, you have poor wound healing, et cetera. So, you’re at risk for secondary malignancies when you’re obese. There’s a higher mortality rate in obese patients. So, I want to give you the big concept so you can think it through with your patients.

                        So, here again, we have just what is the physiology that drives this? So, of course we all know that if you’re sedentary, you eat too much, you get obese. But of course we also know that’s not the only reason. It’s not just calories in calories out. So, want to identify metabolic issues in our patients. But if we are able to lower fasting insulin and lower insulin-like growth factor, we do get more control of cancer. And you can do that pharmacologically, but you can do it with lifestyle as well. And so, for example, if you lower your animal protein, you can lower your insulin-like growth factor.

                        So, it’s this tricky thing now since Gabrielle Lyon published her book, if you read her book on muscle medicine, the need to have adequate protein, which as we age to maintain muscle mass and to maintain metabolic health. And also because of the age demographic of cancer patients, we have a population of people who are potentially sarcopenic. And the physiology of cancer itself drives sarcopenia. Sarcopenia, the loss of muscle mass actually starts when you have a solid tumor. And you can’t see it, you can’t measure it, but it’s actually happening. So, it’s very important since obesity and glycemic control are related to muscle health and muscle mass to realize that all cancer patients are at risk for sarcopenia. And that be thinking about that right from the beginning because the oncologist is not. So, we want to be the team members, the collaborative team members that have this health model for the patient.

Dr. Weitz:          But this is a big dilemma. We want to give the patients more protein. It’s a great way to control glycemic balance, insulin.

Dr. Chilkov:        So, the best way is to exercise and increase your muscle mass. And of course you have to have the signal to the muscle, so you have to have enough leucine. So, I find that a lot of my cancer patients are exhausted and overwhelmed typically. And so, they’re not that interested in cooking or eating sometimes, especially if they’re in the middle of treatment. So, I use free-form amino acid powders, particularly branched-chain amino acid powders to give enough leucine to signal the muscle. That’s what I do. And so, you’re able to get adequate amino acids into people who aren’t interested in food or might not want to eat a lot of animal protein.

Dr. Weitz:          I often hear from vegans arguing a particular amino acid is going to increase your cancer risk. And pick different ones, methionine, glutamine, leucine.

Dr. Chilkov:        All right, well, that’s a little bit of a tangent, but I’ll [inaudible 00:17:24]-

Dr. Weitz:          Okay, sorry.

Dr. Chilkov:        … For a minute because we got to get through this lecture. So, cancer cells are smart. They co-opt our normal physiology for their own survival. And so, they do that in a variety of metabolic ways. But not all cancer cells do all these adaptions. So, there is a fear of glutamine in the misinformed community. And glutamine is the most ubiquitous amino acid in the body. It’s stored in the muscle. And if a cancer cell wants glutamine, it doesn’t have to go anywhere to get it. It’s all around. And so, if we want to give glutamine in order to heal someone’s gut because it’s been eroded by chemotherapy, it’s not going to change whether or not the cancer cell has access to glutamine. So, you still have to think of the whole biosystem.

Dr. Weitz:          You have Thomas Seifried recommending glutamine blocking drugs as part of this protocol.

Dr. Chilkov:        So, there are subset of tumor cells that shift into glutaminolysis. But you can’t block glutamine. It’s like junk science. So, that’s my opinion. So, now that’s on tape. So, the other thing is methionine definitely has a role in proliferation. But again, it’s not every cancer, it’s not every tumor cell line. And going on a low-methionine diet is very risky thing to do. And I am not a proponent of it. And for patients who are at the end of the line, they’ve become treatment resistant and they’re desperate to try something. There’s a subset of patients who respond to low-methionine diets, but those patients become extremely sarcopenic. Extremely sarcopenic. And so, we have a colleague who is in LA here who’s a big proponent of low-methionine diets. And I think if a patient wants to try it, they have to cycle on and off of it because otherwise they just become ill. There’s too many things that are methionine dependent, including your mood. So, these patients become extremely depressed and then they can’t be compliant with an already difficult protocol.

Dr. Weitz:          Thank you. One more quick question. Is there lab test-

Dr. Chilkov:        You can’t keep taking off [inaudible 00:19:53], okay?

Dr. Weitz:          Is there a number for IGF-1 labs that you like to see?

Dr. Chilkov:        I like it to be below a 100.

Dr. Weitz:          Below a 100?

Dr. Chilkov:        Yeah. So, that’s hard. So, that’s hard. Nasa Winters, who some of you are interested in cancer may know she’s a colleague of mine. 125 is reasonable. That’s doable. Completely [inaudible 00:20:11].

Dr. Weitz:          Valter Longo says below 175

Dr. Chilkov:        No, no. Valter Longo doesn’t know anything about health. He is a lab rat. He’s a lab rat. He is theoretical. He’s completely theoretical. I was just on a stage with David Sinclair and he’s the same way. If you guys know who David Sinclair is, it’s a longevity. So, he’s a brilliant guy, he’s like reductionist. And so, we have to be whole systems thinkers. That’s what causes [inaudible 00:20:38], is to understand the whole system. So, it’s great to have people that go deep into research. But Valter Longo and David Sinclair don’t know anything about health. Nothing. Nothing. They know about their pathway. I’ve met him, I’ve talked to them. All right, let’s not get lost. I’m barely through my slides.

Dr. Weitz:          Sorry.

Dr. Chilkov:        All right. So, Ben and I have known each other a long time. So, control yourself. So, anyway, these are the things that we can intervene, help people metabolically, put them on anti-inflammatory diets, teach them how to sleep, teach them how to exercise, teach them how to have a good body composition. So, all the things we already do already become more crucial in cancer patients. All right. So, I have tons of references in here for you. So, these things occur together, obesity and cancer. And diabetes and cancer also occur together. So, in bold are the more glucose and insulin sensitive cancers. And so, people always ask me also about a ketogenic diet. And I am not a fan of [inaudible 00:21:57]. There is actually not a lot of research to support ketogenic diets except in brain cancer and pancreatic cancer, which are the more glucose and insulin sensitive cancers. But a ketogenic diet is not a healthy diet. It is a therapeutic diet. And some patients cannot be on if you have a severe osteoporosis, if you have kidney disease, you cannot be on a ketogenic diet. And it’s a hard diet to maintain.

                        And one of the things I’m very sensitive to is that cancer patients don’t have a normal life, they feel socially isolated, and I want them to be able to even their friends and their family. And so, I don’t want them to become more isolated. And so, I only prescribe ketogenic diets in pancreatic and brain cancers. And otherwise where the research is, where the research is solid, and thank you Walter Longo, is in fasting mimicking diets and in intermittent fasting. That’s where the research is solid, really solid.

Dr. Weitz:          What was the first diet you said, the?

Dr. Chilkov:        Ketogenic.

Dr. Weitz:          No.

Dr. Chilkov:        Fasting mimicking diet. That’s lingo that comes out of Walter Longo and his studies. But his fasting mimicking diet is an intermittent fasting diet and a low carb, low glycemic diet. And he’s marketed it and made a product, which I won’t name on tape, but I don’t like it. And because it’s not healthy foods. See these guys that do all this research, they don’t know what healthy food is. And so, you can’t just go on the ride with them. All right. So, glycemic control and body composition change the growth signal for cancer. That’s the big thing. And they change mortality, they change risk recurrence, they change occurrence of cancer. So, getting control of this is hugely, hugely important.

                        So, there’s also so many more. I mentioned so many surgical complications. So, my goal for hemoglobin A1C, which is probably consistent with the [inaudible 00:24:14] is between 4.8 and 5.2. That’s where I want people to be. And it’s totally doable. You just have to teach people how to do it. Realize cancer patients have high cortisol, they’re really stressed. That can push up their blood sugar and impair their glycemic control. So, realize that’s a contributor in this patient population. A lot of cancer patients have disrupted sleep cycles, which will impair their glycemic control. So, you have to do a very thorough analysis of root cause in etiology to make sure that you’re addressing where the impairment is coming from.

                        The other thing that happens to these patients is they become at risk for secondary cancers. Although I don’t see that a lot in my own practice. The research is there. So, here’s the other infographic that helps you see the big picture, the big picture of this physiology that we’re talking about. So, of course we have patients that are more genetically susceptible to developing insulin resistance and for glycemic control. We have patients that are more susceptible both from environmental signaling and genetics also to developing body composition with more fat. All of these patients have more inflammation. You get signaling from adiponectin and also from leptin that changes the signal to the tumor cell and that changes an environment to make it more hospitable to the development of progression of cancer. So, I actually measure adiponectin in leptin in all my patients, and you can do that.

                        And then when you have more inflammation, you get this sort of cytokine environment. The cancer cell itself will secrete inflammatory cytokines. And then the larger biosystem, if it’s more inflammatory, you get inflammatory both from the cell and from the biosystem itself. And so, this is a highly proliferative environment. And so, controlling inflammation, which we know how to do is really important. The oncologist does nothing on this note. And the oncologist is not interested in insulin or glucose either. And in some chemotherapy infusions prednisone is used to inhibit inflammatory reactions to the drugs. Mostly in platinum chemotherapies this is done. So, this impairs the patient’s ability to sleep, number one, but it also shoots their blood sugar up. So, I ask my patients to ask their oncologist to cut that prednisone in half, and I’ve never had anybody object to that. So, one of the things that I feel we should do is be resources to our patients to understand that they can ask for individualized care.

                        And so, if you know a patient already has glycemic issues, you want to remove the prednisone from their IV. And in fact, they also put antihistamines in the IVs. And so, sometimes that’s sufficient. So, if you think prednisone is a really bad idea for your patient, you can have that conversation with the oncologist. So, I think that’s part of our job, is to help the patient be an educated patient. Help them understand how to ask for care that’s more appropriate to them so that they don’t just get cookbook standard of care cocktails. All right. So, the other thing that happens, of course you have a change in liver physiology and gluconeogenesis. But then you also as you know, will have increased risk of fatty liver disease with all of this as well. So, thank you Peter and Tia do all that for us. So, that’s a factor in this patient population, too. So, we have to be mindful of their liver health in the face of metabolic issues.

                        And so, then what happens in addition to that is you have more body fat, you have more estrogen going on, and then you get changes in sex hormone binding globulin due to that. And so, this whole hormonal milieu and this signaling which becomes proliferative. We know that steroid hormones are proliferative hormones. So, we get this whole tipping of the whole metabolic milieu. And this becomes an environment that is able to host cancer development carcinogenesis, but also increases proliferation and metastasis because you get this going on where a vascular endothelial growth factor, VEGF, increases as does plasminogen activator inhibitor. And this increases coagulation. So, the tumor microenvironment is a microenvironment of thrombus risk. It is a microenvironment of hypercoagulation that’s a fact of cancer.

                        So, two things go on as soon as you have a solid tumor. You start to have sarcopenia signaling as a risk and you start to have hypercoagulation as a risk. So, you want to be mindful of that because 40% of all cancer patients have a thrombotic event. They will either have a thrombus or an embolism. And so, there’s no reason for cancer patients to suffer those if we can prevent it. So, I monitor fibrinogen and D-dimer in my patients. And you will see those go up. Those are markers of hypercoagulation in the cancer setting. Those are reliable markers of hypercoagulation. And oncologists are loathe to anti-coagulate their patients because the drugs are so strong. But we can do it with curcumin, and boswellia, and high doses of omega-3 fatty acids. You don’t want to anti-coagulate your patient, but we can inhibit platelet aggregation. It’s a little harder to inhibit fibrin clots. But that’s what cancer patients get.

                        So, if you see that a patient has high fibrinogen and high D-dimer, then you want to give them something like lumbrokinase or natokinase, which are able to act on the fibrin formation. So, the things we think of as anti-coagulants are the typical things are just inhibiting platelet aggregation. But the risk is fibrin clots and cancer patients need to be aware of that. We can so decrease patient’s risk. And if I see a patient with really high risk of thrombus formation. Like I had a patient come into my office and she had a port in her arm for chemo and she had a chain of lip clots below the port. Now I see the patient more often than the oncologist does. I was doing acupuncture weekly.

                        And so, I called the patient on my cell phone in front of the patient in my office while they were on my table and I said, “We need to anti-coagulate this patient. I’m going to send them over as soon as I’m done here.” And I wanted the patient to hear it, hear me say that to the oncologist. And so, we were able to identify that risk. The patient doesn’t know that shouldn’t be happening. And so, we tend to see our patients more often, more personally and observe them better so we can keep them safer. And what else do you tell a patient who’s got a risk of thrombus? You make them make sure they’re not too sedentary. You make sure they’re hydrated. You make sure they’re on an anti-inflammatory diet. And so, we can really keep people much safer. So, the first slide I showed you, the more general slide about obesity and cancer, et cetera. And then this slide, if you want to go back and really wrap your mind around all the factors that are contributing factors, these two slides really have everything that’s important to pay attention to.

                        And so, we know, again, I mentioned that there’s more insulin receptors on tumor cells and that’s why it’s really important to get control of insulin and blood glucose. Okay. So, there are other factors that drive obesity. We know that menopausal women tend to have different relationship to percentage of body fat. So, that’s the patient population that we’re typically working with in this age group. If you have a younger patient, it might actually be someone who had ovarian or endometrial cancer who had a hysterectomy. So, then she becomes in this group as well. As we always do, we always understand the patient’s lifestyle, which the oncologist doesn’t even ask about. And so, you want to be paying attention to that. So, you can see here that as I was talking about this estrogenic effect of obesity and we get changes in sex hormone binding globulin change in the ratio of free and bound hormone.

                        And so, we get changes in signaling and we get increased aromatase. And aromatase is an enzyme in the tissue that converts androgens to estrogens. So, you get more estrogen signaling. Which is why women who have estrogen-driven breast cancers are more at risk if they’re obese or have glycemic issues. It’s a high-risk population. Super high-risk population. A lot of them are in our offices because they want us to help them with their menopause. So, we got their ear. And so, we want to attend to this. And then because lifestyle runs in families, so do all these risk factors, it’s not just genetics. So, we have an opportunity to affect more people in one family if we do our patient teaching in that way.

                        All right. So, I want to hit the highlights so that we can just have a conversation. I think I made this point. But this is really interesting. Oh no, this isn’t the slide I want to talk about. But anyway, you can see that diabetes and glycemic issues are really a driver of breast cancer. But also say estrogen-driven cancers include other cancers. So, lung cancer can have estrogen receptors. Pancreatic cancer can have estrogen receptors. Colorectal cancer, brain cancer, prostate cancer. There’s a lot of cancers we don’t think of as hormonal cancers that have estrogen receptors on them. And so, you can request the pathologist to check.

                        All right. So, here’s what I wanted to talk about was the role of intermittent fasting and carbohydrate restriction. We know that this is a way to get glycemic control. But there’s all these studies on cancer patients and intermittent fasting. And so, I just want to say, there are historically what I call old naturopathic ideas about water fasting in cancer. That’s not what I’m talking about because that is too high risk for sarcopenia in this population. It’s just too high risk. And so, I don’t water fast people over 50 because they need their muscle mass. So, if you have a young patient who’s in good shape, they can tolerate some loss of muscle mass, they’ll get it back. But an older patient’s not going to get it back.

Dr. Weitz:          What about water fasting just before and just after chemo?

Dr. Chilkov:        I don’t want to put my patient at risk for sarcopenia, period. So, the question was what about water fasting before chemotherapy? The better question is what about fasting before chemotherapy? So, we know that there’s good studies that show if you stress tumor cells by making glucose unavailable to them, the cancer cells already stressed when the chemo is administered so you get a higher kill rate. So, it is well documented. However, I’m very careful. So, I look at the patient. If the patient is already underweight and undermuscled, I don’t do that. So, what I have that patient do is maybe drink bone broth or do a protein shake that has no fruit in it at all, and just get or just do branched chain amino acids, something to protect their muscles while we’re stressing the tumor cell does not get this impact. This stress comes from withholding glucose to the tumor cell.

                        So, if you can accomplish that and preserve muscle, that’s your goal. That’s my approach. Okay. That’s my approach. So, if I have a more robust patient, I’ll have them just do protein shakes or bone broth for 48 hours if they’re pretty robust. Some people will do it 24 hours. If somebody can only do it 13 hours, the data shows 13 hours enough to get a switch in the metabolism and have an impact. So, it depends how robust and also how psychologically motivated, and if somebody has experience with fasting and all of that. And they must be well hydrated. When you’re having an infusion of chemotherapy or anything else, you have to be well hydrated. You want to keep diluting what is coming into your system. And so, actually have people drink bone broth during their infusion. So, they’re getting fluids, electrolytes, and some protein. And that keeps them from getting into trouble with their kidneys also. Really, really protects the kidneys and the gut as well. Yes.

Speaker 4:         Do you recommend intermittent fasting for someone’s in remission?

Dr. Chilkov:        Yes. I actually think intermittent fasting as a lifestyle is really great, actually for everyone.

Speaker 4:         But how long?

Dr. Chilkov:        I think I have a study here. Let me see if it’s here. So, here’s the impact of carbohydrate restriction. And I do have sliding here somewhere on the study. So, there’s this balance between enough protein and lowering carbs. And what happens to people is they do need some dietary guidance. I have a nutritionist that works in my practice because when people just take their carbs out, they lose weight. And so, this patient population cannot lose weight. They need to maintain their weight unless they’re over fat, then we want them to lose fat but not muscle. So, if you take the calories out from carbs, you have to replace that with healthy fats with protein so that you maintain your weight. So, there’s some patient teaching that has to go on with that.

                        And I often will put a therapeutic shake into the protocol because again, these patients are not really that interested in food or in cooking for a lot of their treatment cycle. Afterwards, they may be. But during, they’re not, and they really need to be protected. So, they feel well also while they’re going through treatment and that they do well while they’re going through treatment, they have enough nutrients to repair the damage that the chemo causes. So, I do have a study in here, it’s coming up. 13 hours is out of it. 13 hours is out of it. Let me find that slide.

Speaker 4:         Like they do that every day?

Dr. Chilkov:        Yes. It doesn’t take much to fast for 13 hours. You eat breakfast a little later or dinner a little earlier. It’s not hard to do. It’s not to do at all. And if they wanted to have something in that window, they could have branched-chain amino acids during that time. It doesn’t disrupt this physiologic switch we’re trying to accomplish. So, it’s not hard to do. So, I actually recommend it to everyone who has cancer history, cancer risk, or is going through treatment. And then it becomes a lifestyle. So, I’m trying to teach people how to eat for their life, not for their key. And so, I think it’s really important that patients who are going through surgeries really need to keep their protein together and their gut together.

                        Just giving probiotics around any surgery decreases surgical complications in all patients, not just abdominal surgeries. Why? Because of its impact on inflammation and immunity. So, it’s really important and on mood as well, on neurotransmitters. So, at any rate, this is a classic ketogenic diet. And so, I don’t want to spend a lot of time talking about it. If you want to learn about ketogenic diets, I actually gave a really long lecture on one of the supplement companies that I can’t name during the recorded lecture, but I’ll tell you afterwards. There’s a long lecture on this online. Anyway, I don’t recommend it unless pancreatic with brain cancer. Or you could do a ketogenic diet for a couple of days before chemo. But you’re not going to get into full ketosis if you want to do for a couple of days. You only get a therapeutic mileage out of a ketogenic diet if you sustain ketosis.

                        It’s hard to do. You don’t feel well, people get diarrhea. It’s not an easy thing to do when you already don’t feel well. You already don’t feel well. So, I am very, very sensitive to what’s worth doing. What’s worth asking a cancer patient and a family to do cancer doesn’t affect just the patient, it affects their whole family. And so, it has to be sustainable over time. If it’s too hard, it’s not going to work. But anybody can do intermittent fasting and low-carb diet. Anybody can do that, teach them how to do it. It’s not hard to do. So, here is this study. This is a really cool study. It was done with a 13-hour window and it was done with thousands of breast cancer patients. It was a European study. And they found that it changed IGF-1 levels and that it was better than just calorie restriction itself. It was just better to do intermittent fasting.

                        And there’s a lot of different ways to do intermittent fasting. You can do low calories two days a week or like that. But that’s too complicated for people. Which days is it? What are they going to eat? Just fast. Just don’t eat 13 hours of every 24. It’s really easy for people to put that in their lives. So, I have some statistics here, let me find them. So, this was a cohort of 2,400 plus women in early stage breast cancer. And it was a wide age range, which I liked and it was a seven-year follow up. So, I liked this study. 21% lower risk of dying from breast cancer by doing 13 hours of fasting out of every 24. That’s pretty good solid motivation I think to integrate this. And then there were some more statistics, change rates of recurrence changes mortality, as well as recurrence. So, I like that study a lot.

                        So, now let’s just talk about interventions. So, those are the big physiologic functional ideas and we can talk about them more if you want. But let’s look at interventions. So, what time is it? [inaudible 00:44:31]. We’ve got time. Okay, so omega-3 fatty acids are very important in the tumor microenvironment for a variety of reasons. And so, not only for inflammation but also reduces tumor cell adhesion, which is another reason to really optimize omega-3s. I measure them. There’s LabCorp and West has the omega check test, which are sufficient. There’s more sophisticated tests. But those are sufficient to see if the dose of omegas that you’re giving your patient is optimized for them. And so, I tend to dose high on these. I give most of my patients get a minimum of four grams a day of omega-3 fatty acids. If you have a particularly inflamed person or a person with more brain inflammation, I like to use the pro-resolving mediators, the SPMs. Those really are powerful. And especially if someone’s feeling depressed, that also really helps them.

                        Remember that the blood-brain barrier is compromised in all cancer patients due to the high level of matrix metalloproteinases. And so, the SPMs are really great for the brain. Of course the EPA is also. But even better is the phosphatidylcholine-bound omega-3 fatty acids. Those get into the brain preferentially. And so, there’s a couple supplement companies that make phosphatidylcholine-bound, omega-3s. And anybody for example, who has an APOE4 allele, they must have those phosphatidylcholine-bound omega-3s because they have an error in transport of omega-3 fatty acids into the brain, which is why they’re at risk for dementia.

Speaker 5:         What does [inaudible 00:46:26] like for the SPMs? Do you do those in addition?

Dr. Chilkov:        Yeah, I’ll do them concurrently. Yeah, it’s too expensive to do just the SPMs by themselves. So, I’ll give four grams of the EPA, DHA. And then I’ll give two cats twice a day of the SPMs on top of that. And sometimes that’s just phenomenal what that can do for patients. It’s expensive, but it’s therapeutically very powerful. And then as I mentioned, I do a therapeutic shake. So, I wanted to show you what I put in that shake. And one of the things that I like to add, especially if people are having trouble getting enough calories and feel fatigued, you can put medium-shake triglycerides in there. And I really like to put carnitine into either the capsules or powder. A lot of the companies have stopped making powdered carnitine recently. And it makes the shake taste very sulfury. So, people don’t like it. But about two grams of extra L-carnitine, not Acetyl-L-carnitine, L-carnitine for the muscle and the mitochondria.

                        So, when you give that extra carnitine, you address some of the mitochondrial fatigue that cancer patients have, but you also address muscle physiology because you get better energy delivery and fatty acid metabolism in the muscle. And remember that the biokines that are secreted by the muscle also have an impact on immunity. And so, this whole idea of paying more attention to muscle-centric medicine I think is really important. I don’t know, when I went to school nobody ever talked about it. So, I think it’s really important. I think it’s a good contribution.

                        And then you want to make sure people are getting some soluble fiber. Patients think of fiber as insoluble fiber. And so, to teach them where soluble fiber comes from or give them powders to take so that their microbiome has some sustenance. That’s how I put that together. And also you can add more fatty acids to the shake, and add calories and more fatty acids that way. I find these dense shakes, if you put a half of an organic lemon with the rind into the blender, it just brightens up and lightens up the taste of the shake. That was the idea for Mark Kleinman. You can put half an avocado in the shake to give more calories. A lot of these patients are having trouble getting calories, because they don’t have any appetite, or they’re nauseous, or they don’t feel like cooking.

                        So, some people, especially after they have their chemo infusions, a lot of them don’t feel like eating for three to five days. They can live on two or three shakes a day and some branch chain amino acids, and bone broth until they feel like eating. As long as you put some greens powder or some greens into the shake and they’re getting some phytochemicals along with all of this. I also put in some of the Chinese mushrooms into the shakes. The only contraindication to using Chinese mushrooms in these patients is if they’re on PDL-1 and PD-1 blockers, the immunotherapies. Because these are therapies which take the breaks up the immune system. And so, we don’t want to be ramping up their immune system while the drug is doing that. We can cause a forest fire of inflammation where we only want an ember. And so, you want to be careful with Chinese mushrooms, and astragalus, and echinacea, these phytochemicals that push on the immune system. You have to be careful. In the same way, you have to be careful with autoimmune patients in that same way.

                        So, that’s just my shake recipe. Berberine is really great for this patient population because as you all know, berberine is very important. What is that? Oh, somebody opened the door. Okay. So, as you know, berberine is a good agent to use for glycemic control. But look at this slide. Berberine interacts with over 20 different pathways that infect cancer physiology. So, you want to look for multi-taskers. Phytochemicals are phleomorphic. They can bind to multiple receptors and influence multiple pathways. You guys are going to get the slides. So, anyway, berberine is in the news because glycemic control. But I simply want to point out that it’s really powerful in multiple pathways in cancer physiology. It is also like many phytochemicals, very important in changing the microbiome as well and changing how we utilize phytochemicals.

                        So, we’re running out of time. So, let me just go through these. Curcuminoids also have a big impact on glycemic control. They’re not usually thought of in that context. But I want to point out that they do have an impact on glycemic control. This slide also shows you that curcumin also actually affects the pancreatic beta cells. It affects adiponectin, triglycerides, and leptin, and liver fibrosis. So, I think that we tend to get a little siloed in our thinking about some of these phytochemicals. And I have to say, botanical medicine is my first love because of the fabulous multitasking and ability for molecules from nature to bind to multiple receptors and interact with multiple pathways. And so, curcumin is widely used in cancer as you all know. But you can see here there are certain cancers, it’s more powerful. And I use this in almost all of my patients.

                        There’s a subset of patients who get some enteritis from curcumin. So, if you have one of those, use boswellian instead or together. Resveratrol also exerts glycemic control. We don’t think of it that way, but it does. It also has an impact on fatty acids. And resveratrol interacts with multiple pathways that affect tumor cell metabolism. Green tea, you’re all familiar with that in terms of its impact on obesity and body composition. But it also of course has multiple signaling pathways for glycemic control as well. And ganoderma, which is reishi mushroom, also has a big impact on blood sugar. And it’s also one of the only Chinese mushrooms that has a lot of anti-inflammatory effect that you can use it in an autoimmune patient. You don’t have to be so worried about that. So, I really like it because it has this glycemic control, tumor control. Also, it has a big impact on mood. And in the Taoist culture it was used for meditation. And so, that’s why it’s so famous. Affects gastric emptying also.

                        So, let me just summarize because we have 20 minutes. We can have some discussion and you can look back at these slides. So, obesity is linked to cancer and diabetes. Chronic hyperglycemia, hyperinsulinemia and elevations in IDF-I facilitate tumor genesis and worsen outcome. Patients with diabetes really and hyperglycemia hyperinsulinemia need our patient teaching, and need to learn how to get it right. And because there’s this 40% increased risk of occurrence and recurrence in this patient population, there are obese or diabetic or both, the risk is really high and for the complications of traumas formation as well, and complications of surgeries and treatments. And so, we got their attention. We’re the ones that have their attention on this. So, I think it’s really important.

                        So, these are the things that we talked about today that I chose to include as interventions. So, you think about curcumin, resveratrol, green tea, berberine, ganoderma, the omega-3 fatty acids, put the SPM’s in there. And think about carbohydrate restricted diets, low glycemic diets, intermittent fasting and ketogenic diets where appropriate. You can also include the idea of fasting before chemotherapy adjusted to the patient, what’s appropriate for that patient. And that’s how you get a hold of my assistant. And I have a bunch of references in here for you. And then here’s this handout if you want it. And here’s this discount. If you’re interested in my course, if you just want to talk to me about the course, we have a payment plan. And it’s my legacy project is to pass on this out to our cancer system that I created to all of you. Thank you. We can take as many questions as you [inaudible 00:56:05].

Dr. Weitz:          What do you think about apricot seeds that make the blood?

Dr. Chilkov:        So, there’s a lot of cancer therapies that have been done for a long time. And I think what we need to do is be mindful of where the science is. So, there’s a lot of things that have been used in naturopathic oncology that don’t really have good science behind them. I think amygdala does, but it’s so toxic. And I think we have better choices. We understand cancer cell metabolism better. We don’t have to give people cyanide, which is what that is. There’s a better ways to manage cancer.

Speaker 6:         I have few questions.

Dr. Chilkov:        I don’t use it. So, I don’t use it.

Speaker 6:         Do you recommend that these will all be in the form of extra supplementation with supplements? Or can you get this for the diet? I always worry about [inaudible 00:56:50] supplement.

Dr. Chilkov:        So, great question. In order to change signaling in tumor cells, you have to give a pharmacologic dose. You cannot give a nutritional dose. So, you have to think high-dosing. And so, I’ll give two or three grams of berberine a day. I’ll give four to six grams of omega fatty acids a day. I’ll give three to five grams of resveratrol a day. You cannot change a cancer cell’s behavior or change the signaling in the cancer environment with a nutritional dose. Great question. Great question.

Speaker 6:         How do you feel about, I guess the senolytics are there too, but like senolytic or NAD, NR, NMN.

Dr. Chilkov:        So, all those things, yeah, all those things are important. I focused on the things that impact glycemic control. There are certainly multiple things that influence other pathways and cancer cell metabolism. But in that context, you think about mitochondrial function. If you widen your thinking out to mitochondrial function, you start to think about other things like nicotinamide, ribonucleoside, or NNN. Or you start to think about all the B vitamins that drive the cancer. You want to think about optimizing mitochondrial function in these patients, which is where [inaudible 00:58:13] contribution comes in. But he’s too narrow. And [inaudible 00:58:16] ideas have not been really supported by research. So, you have to realize that.

Dr. Weitz:          Now isn’t there a risk of increasing cancer with NR or NNN?

Dr. Chilkov:        So, theoretically there is. So, I’m conservative. I’m a very middle path clinician. Very middle path. So, the things I’ve told you that I give in high doses I think are super safe. But there are things that are questionable. So, I think you can use the senolytics, which curcumin’s in that category, resveratrol’s in that category. Those things are in that. I like Ficetan quite a lot. I think there’s a lot there. I like to stick with things that have human studies over time when we are thinking about cancer patients. As a clinician, I do not experiment on my patients. I’ll experiment on myself, but not on my patients. And so, I think we have to be careful.

                        And baby boomers like me are becoming hysterical about aging. So, I’ll be 71 this year. And so, we have to be careful to not go off the deep end and create Frankenhumans or whatever. We have to be careful because anytime you leverage only one pathway, you’re going to get into trouble. And so, I do think it’s not clear. I think as we age, we need to enhance our NAD pathways. And so, be conservative on that. An aging person needs more efficient mitochondria. But maybe we don’t go into these big therapeutic pharmacologic type doses of these other things I’ve mentioned that I know are safe in those doses. So, I think it’s too new. We don’t know the answer to that.

Speaker 7:         What about IV nutrients? Some practitioners even use IV [inaudible 01:00:19].

Dr. Chilkov:        So, you have to realize I also recommend them, but let’s have context. So, IV therapies are temporary, unlike when we prescribe something more that a patient takes every day. So, the day you get your IV, it has an impact for a few hours and then you pee it all out. So, you have to remember that. So, what are you trying to accomplish when you give an IV? So when you give high dose IV vitamin C, it becomes a pro-oxidant. In low doses it’s an antioxidant. But when you give it in high dose IV 50 to 75 grams per push, then it becomes a pro-oxidant and causes the production of hydrogen peroxide in the blood, which kills cancer cells and spares healthy cells. Not all patients tolerate that. Some people get hyperglycemic when you do that. So, you have to find out.

                        Also, you have to make sure high dose IV vitamin C is safe. You have to measure an enzyme G6 PD to make sure that they will not have red blood cell lysis when you give them high dose IV vitamin C. There are clinicians who are specialized in treating cancer patients with these IV therapies. And there are some good people here in LA and around the country that do that. But just because somebody does IVs in their office doesn’t mean they should be treating cancer patients with IVs.

                        You can give IV resveratrol, IV lipoic acid, IV curcumin. There’s a lot of to IV NAD, there’s IV phosphatidyls pulling. But you need a highly trained person to administer these therapies because… and also I insist that if we’re going to treat cancer patients with these aggressive IV therapies, there better be a nurse in a crash cart in that office. And the team there better be trained to deal with an emergency. And there’s all these clinics where that’s not so, and they’re not safe. And these are vulnerable, fragile patients. These are not healthy patients going for a little upper on their IV. And so, these are fragile, fragile patients and they have to be in a safe medical setting. Yes.

Speaker 8:         Have you heard of C15 or what is it?

Dr. Chilkov:        Those fatty acids? Yeah. I don’t think there’s enough information there to do anything. Yes.

Speaker 9:         Do you have any comments on beta-glucuronidase activity [inaudible 01:02:56]?

Dr. Chilkov:        I didn’t understand you.

Speaker 9:         Do you have any comment on beta-glucuronidase activity, the stool test at risk for the breast cancer?

Dr. Chilkov:        I’m not understanding.

Dr. Weitz:          Oh, some stool test report on beta-glucuronidase.

Dr. Chilkov:        Oh, [inaudible 01:03:11]. Yes. Yes, absolutely. So, if you have an estrogen-driven cancer, I have a whole lecture on the estrovalome, which is the way that the microbiome influences estrogen metabolism. And so, beta-glucuronidase is involved in conjugation and decontagation of estrogens in the gut. And so, if you have high levels of beta-glucuronidase, you have higher levels of decontagation of estrogen. What does that mean? So, estrogen in the bloodstream goes through the liver it gets conjugated, and excreted through the bile into the stool. If there’s too much beta-glucuronidase in the gut, that gets decontagated, which means that estrogen goes back into the general circulation and you get a double whammy hit of your own estrogen. So, patients who have that have a certain type of estrogen dominance essentially. So, you need to fix that. Yeah, you need to fix that. A whole lecture just on that subject.

Speaker 10:       What do you think about melatonin? Some practitioners now are using 200, 300 milligrams a day.

Dr. Chilkov:        So, melatonin can be used to alter tumor cell metabolism at multiple effects. And again, I’m a conservative clinician. So, all the original studies were done by a group in Italy that studied 20 milligrams of melatonin at bedtime as a dose in breast cancer patients. However, we think of melatonin in this very narrow way, but it has a lot of impacts on multiple pathways and metabolic pathways in the cell and in particular has an influence on cancer cells. And there is a rationale to give high doses of melatonin to patients. I’ve never gone myself over 180 milligrams. That’s plenty melatonin, I think.

                        And so, it’s interesting because I think melatonin is misunderstood. Melatonin is not a sedative. Melatonin is a dark signal to the brain. And so, it tells you it’s nighttime. It tells you to get ready for sleep. So, when you get into these pharmacologic doses, it’s not about that. It’s about changing metabolic pathways and cells, and some of which drive proliferation. And it’s pretty safe. I’ve never really seen anybody get into trouble with it. Patients, I think of this placebo effect where they think they’re sleepy because they’re taking melatonin until they explain to them it’s not a sedative. And they can wake up refreshed after they take a high dose of melatonin.

                        But I always start slow. I never go way up there. I’ll start somebody on 20 or 40 milligrams, and then up to 80. And I’ll go upstairs, get people up to see how they do. There are some people who just don’t rate it very well. The primary adverse effect is wild dreams. And so, that’s as bad as it gets. But for some people, that’s not normal. So, you can modulate it down then. But it is quite effective. But I tend not to go straight to those therapies. There are patients who do quite well, do anything extreme. But there are subsets of patients who become treatment resistant in the standard of care oncology setting, in which case we need to really think about what can we do that’s a big lever for them to really change their course of progression.

                        But realize most of the naturopathic therapies don’t kill cancer cells. Most of our therapies are metabolic therapies. You have to really realize that there are times when you need something that’s really toxic, that’s going to kill cancer cells because in some patients, you really need to reduce tumor burden quickly. And there’s nothing in natural medicine that does that. So, that’s why I call my approach integrative because I always ask the question, what’s the right tool for the job? Or what are the right combinations of tools for the job? And some people really, really, really need toxic chemotherapy to reduce their tumor burden for a period of time. And so, the enemy is not chemotherapy. The enemy is cancer. So, you have to have a way of thinking about how you’re going to give this person a good long life and quality of life. And sometimes chemotherapy is part of that solution for a finite period of time. And where people get into trouble is over-treated with chemotherapy. But it has a place.

Speaker 11:       I know you said you don’t experiment on your patients. Do you have any thoughts on peptides minus and alpha that have been showing in research that we do?

Dr. Chilkov:        I think we could say, what about off-label use of drugs? We could say that, too. So, I do think that there are some things that are quite safe to do. And if we’re in the realm of safety, why not? Why not if there’s a good rationale? But I still think you have to look at your patient. What are the metabolic pathways in their tumor cell line? What are their comorbidities? What will they tolerate? What can they afford? So, I look at all of that. I think there’s a lot of things we can do with off-label use of drugs like statins interrupt metabolic pathways significantly in numerous cancers. They’re cheap, they’re safe, and things like that. There’s metformins widely used in the cancer setting. So, I think that that’s a whole other lecture also.

                        But I think if it’s something safe, I think it’s safe to try. Metformin tries statin, try something like a well thought-through peptide. I don’t think there’s any reason not to. Everything I do is individualized. You have to just look at the patient. And I’m very mindful of how much I ask them to do and ask them to spend. And so, if someone really has limited financial resources, then I really want to make sure that what I’m giving them are the big levers that I do know are going to make a difference. It’s quite different when you have a stage four patient that’s become treatment resistant and then you have to think about all other kinds of things.

Speaker 11:       Any thoughts on giving it to younger patients and possibly proliferating cancer?

Dr. Chilkov:        Giving one to [inaudible 01:09:59].

Speaker 11:       Different peptides, because I think there’s a lot of [inaudible 01:10:01].

Dr. Chilkov:        I think we don’t know enough about peptides. I think, look what’s happening with [inaudible 01:10:06]. I mean, it’s the Wild West as far as I’m concerned. It’s dangerous. What we’re doing is dangerous. And so, here we’re in LA welcome to the Hollywood. So, everybody wants to be thin and rich. And so, we always at least be thin. Maybe not rich if you buy your [inaudible 01:10:27]. But I think I am just careful. These are really fragile, vulnerable patients. But it’s tricky because you also have the family to deal with. And so, you might have a patient that wants to engage in the kind of therapies that we include and their family’s freaked out about it or as a willing to spend the money on it.

                        And it’s tricky because I do feel that patients values and wishes for themselves should be respected. And sometimes the family just can’t deal with it. Or the family’s so terrified that the patient’s going to die, that they want to do everything the oncologist says, even though the oncologist stuff isn’t working anymore. It’s complicated. It’s very kind that people have different feelings about death, and mortality, and suffering. And I always say, if you want to work with cancer patients, you have to have a level of complexity. I think it keeps it interesting. Yes.

Speaker 12:       I just want to make sure I didn’t… I know I misheard something earlier about when you were talking about the diet, about the animal protein. You were like some decreased animal protein. But then [inaudible 01:11:38].

Dr. Chilkov:        So, I restrict red meat because there’s a lot of studies showing that red meat is very carcinogenic. And so, I restrict that. And it’s largely because of the iron in red meat. Cancer cells sequester iron and use it for their own metabolism. And so, there’s a whole line of cancer cell physiology, which is involved with ferroptosis and leverages iron as a way to-

Speaker 12:       I heard the protein and then you immediately-

Dr. Chilkov:        Yeah. Yeah. So, cancer patients need protein to maintain muscle mass or restore muscle mass that they’ve lost. So, if they have a high IGF-1, then you have to try and figure out what protein is going to build their muscle and not increase their idea of blood.

Speaker 12:       What was the name of the BCAA powder?

Dr. Chilkov:        There are many companies that make branch chain amino acid powders. Many, many companies. I just pick high quality companies where it doesn’t taste terrible. Basically, I taste everything before… different companies make better tasting things. So, it’s eight o’clock. Are we supposed to stop any-

Dr. Weitz:          Yeah, I guess theoretically [inaudible 01:12:57].

Dr. Chilkov:        Until we get kicked out. Should we get kicked out?

Dr. Weitz:          Thank you everybody.

Dr. Chilkov:        Thank you everyone. Oh, I have something for you. Wait a minute.

 


 

Dr. Weitz:          Thank you for making it all the way through this episode of the Rational Wellness Podcast. For those of you who enjoy listening to the Rational Wellness Podcast, I would appreciate it if you could go to Apple Podcasts or Spotify and give us a five-star ratings and review. If you would like to work with me personally to help you improve your health, I do accept a limited number of new patients per month for a functional medicine consultation. Some of the areas I specialize in include helping patients with specific health issues like gut problems, neurodegenerative conditions, autoimmune diseases, cardiometabolic conditions, or for an executive health screen. And to help you promote longevity and take a deeper dive into some of those factors that can lead to chronic diseases along the way. Please call my Santa Monica Weitz Sports Chiropractic and Nutrition office at 310-395-3111, and we’ll set you up for a new consultation for functional medicine. And I look forward to speaking to everybody next week.